-- dump date 20140620_000214 -- class Genbank::misc_feature -- table misc_feature_note -- id note 59922000001 DNA polymerase III subunit beta; Validated; Region: PRK05643 59922000002 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 59922000003 putative DNA binding surface [nucleotide binding]; other site 59922000004 dimer interface [polypeptide binding]; other site 59922000005 beta-clamp/clamp loader binding surface; other site 59922000006 beta-clamp/translesion DNA polymerase binding surface; other site 59922000007 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 59922000008 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 59922000009 dimerization interface [polypeptide binding]; other site 59922000010 ATP binding site [chemical binding]; other site 59922000011 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 59922000012 dimerization interface [polypeptide binding]; other site 59922000013 ATP binding site [chemical binding]; other site 59922000014 amidophosphoribosyltransferase; Provisional; Region: PRK09246 59922000015 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 59922000016 active site 59922000017 tetramer interface [polypeptide binding]; other site 59922000018 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 59922000019 active site 59922000020 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit [DNA replication, recombination, and repair]; Region: GyrA; COG0188 59922000021 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 59922000022 CAP-like domain; other site 59922000023 active site 59922000024 primary dimer interface [polypeptide binding]; other site 59922000025 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 59922000026 TPR repeat; Region: TPR_11; pfam13414 59922000027 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922000028 binding surface 59922000029 TPR motif; other site 59922000030 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 59922000031 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 59922000032 Uncharacterized conserved protein [Function unknown]; Region: COG2928 59922000033 transcription antitermination protein NusB; Provisional; Region: nusB; PRK09634 59922000034 putative RNA binding site [nucleotide binding]; other site 59922000035 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 59922000036 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 59922000037 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 59922000038 P loop; other site 59922000039 GTP binding site [chemical binding]; other site 59922000040 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 59922000041 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 59922000042 argininosuccinate lyase; Provisional; Region: PRK00855 59922000043 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 59922000044 active sites [active] 59922000045 tetramer interface [polypeptide binding]; other site 59922000046 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 59922000047 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 59922000048 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 59922000049 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 59922000050 FMN binding site [chemical binding]; other site 59922000051 active site 59922000052 catalytic residues [active] 59922000053 substrate binding site [chemical binding]; other site 59922000054 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 59922000055 SelR domain; Region: SelR; pfam01641 59922000056 flavoprotein, HI0933 family; Region: TIGR00275 59922000057 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 59922000058 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 59922000059 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 59922000060 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 59922000061 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 59922000062 Walker A motif; other site 59922000063 ATP binding site [chemical binding]; other site 59922000064 Walker B motif; other site 59922000065 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 59922000066 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 59922000067 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 59922000068 Walker A motif; other site 59922000069 ATP binding site [chemical binding]; other site 59922000070 Walker B motif; other site 59922000071 GrpE; Region: GrpE; pfam01025 59922000072 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 59922000073 dimer interface [polypeptide binding]; other site 59922000074 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 59922000075 chaperone protein DnaJ; Provisional; Region: PRK14293 59922000076 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 59922000077 HSP70 interaction site [polypeptide binding]; other site 59922000078 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 59922000079 substrate binding site [polypeptide binding]; other site 59922000080 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 59922000081 Zn binding sites [ion binding]; other site 59922000082 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 59922000083 dimer interface [polypeptide binding]; other site 59922000084 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 59922000085 CPxP motif; other site 59922000086 ribosome small subunit-dependent GTPase A; Region: TIGR00157 59922000087 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 59922000088 GTPase/Zn-binding domain interface [polypeptide binding]; other site 59922000089 GTP/Mg2+ binding site [chemical binding]; other site 59922000090 G4 box; other site 59922000091 G5 box; other site 59922000092 G1 box; other site 59922000093 Switch I region; other site 59922000094 G2 box; other site 59922000095 G3 box; other site 59922000096 Switch II region; other site 59922000097 hypothetical protein; Validated; Region: PRK00153 59922000098 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 59922000099 FAD binding domain; Region: FAD_binding_4; pfam01565 59922000100 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 59922000101 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 59922000102 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 59922000103 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 59922000104 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 59922000105 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK07403 59922000106 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 59922000107 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 59922000108 thiamine monophosphate kinase; Provisional; Region: PRK05731 59922000109 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 59922000110 ATP binding site [chemical binding]; other site 59922000111 dimerization interface [polypeptide binding]; other site 59922000112 cyclophilin_TLP40_like: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) similar ot the Spinach thylakoid lumen protein TLP40. Compared to the archetypal cyclophilin Human cyclophilin A, these proteins have similar peptidylprolyl...; Region: cyclophilin_TLP40_like; cd01924 59922000113 active site 59922000114 elongation factor P; Validated; Region: PRK00529 59922000115 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 59922000116 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 59922000117 RNA binding site [nucleotide binding]; other site 59922000118 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 59922000119 RNA binding site [nucleotide binding]; other site 59922000120 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 59922000121 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 59922000122 carboxyltransferase (CT) interaction site; other site 59922000123 biotinylation site [posttranslational modification]; other site 59922000124 4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK02746 59922000125 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 59922000126 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 59922000127 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 59922000128 putative NAD(P) binding site [chemical binding]; other site 59922000129 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 59922000130 active site 59922000131 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 59922000132 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 59922000133 ATP binding site [chemical binding]; other site 59922000134 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 59922000135 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 59922000136 ATP-binding site [chemical binding]; other site 59922000137 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 59922000138 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 59922000139 homodimer interface [polypeptide binding]; other site 59922000140 pyridoxal 5'-phosphate binding site [chemical binding]; other site 59922000141 catalytic residue [active] 59922000142 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 59922000143 GMP synthase; Reviewed; Region: guaA; PRK00074 59922000144 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 59922000145 AMP/PPi binding site [chemical binding]; other site 59922000146 candidate oxyanion hole; other site 59922000147 catalytic triad [active] 59922000148 potential glutamine specificity residues [chemical binding]; other site 59922000149 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 59922000150 ATP Binding subdomain [chemical binding]; other site 59922000151 Ligand Binding sites [chemical binding]; other site 59922000152 Dimerization subdomain; other site 59922000153 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 59922000154 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 59922000155 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 59922000156 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 59922000157 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 59922000158 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 59922000159 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 59922000160 NAD(P) binding site [chemical binding]; other site 59922000161 active site 59922000162 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 59922000163 ThiS interaction site; other site 59922000164 putative active site [active] 59922000165 tetramer interface [polypeptide binding]; other site 59922000166 colanic acid biosynthesis protein WcaM; Region: WcaM; TIGR04004 59922000167 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922000168 binding surface 59922000169 TPR motif; other site 59922000170 TPR repeat; Region: TPR_11; pfam13414 59922000171 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 59922000172 23S rRNA binding site [nucleotide binding]; other site 59922000173 L21 binding site [polypeptide binding]; other site 59922000174 L13 binding site [polypeptide binding]; other site 59922000175 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 59922000176 Stage II sporulation protein; Region: SpoIID; pfam08486 59922000177 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 59922000178 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 59922000179 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 59922000180 DXD motif; other site 59922000181 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 59922000182 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14948 59922000183 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 59922000184 Walker A motif; other site 59922000185 ATP binding site [chemical binding]; other site 59922000186 Walker B motif; other site 59922000187 arginine finger; other site 59922000188 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 59922000189 Lecithin retinol acyltransferase; Region: LRAT; pfam04970 59922000190 Peptidase S8 family domain in Protein convertases; Region: Peptidases_S8_Protein_convertases_Kexins_Furin-lik; cd04059 59922000191 calcium binding site 1 [ion binding]; other site 59922000192 active site 59922000193 catalytic triad [active] 59922000194 calcium binding site 2 [ion binding]; other site 59922000195 calcium binding site 3 [ion binding]; other site 59922000196 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 59922000197 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 59922000198 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 59922000199 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 59922000200 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 59922000201 Walker A motif; other site 59922000202 ATP binding site [chemical binding]; other site 59922000203 Walker B motif; other site 59922000204 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 59922000205 Clp protease; Region: CLP_protease; pfam00574 59922000206 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 59922000207 oligomer interface [polypeptide binding]; other site 59922000208 active site residues [active] 59922000209 trigger factor; Provisional; Region: tig; PRK01490 59922000210 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 59922000211 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 59922000212 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 59922000213 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 59922000214 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 59922000215 dihydrodipicolinate synthase; Region: dapA; TIGR00674 59922000216 dimer interface [polypeptide binding]; other site 59922000217 active site 59922000218 catalytic residue [active] 59922000219 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 59922000220 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 59922000221 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 59922000222 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 59922000223 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 59922000224 Ligand Binding Site [chemical binding]; other site 59922000225 Protein of unknown function (DUF561); Region: DUF561; pfam04481 59922000226 Membrane protein of unknown function; Region: DUF360; pfam04020 59922000227 excinuclease ABC subunit B; Provisional; Region: PRK05298 59922000228 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 59922000229 ATP binding site [chemical binding]; other site 59922000230 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 59922000231 nucleotide binding region [chemical binding]; other site 59922000232 ATP-binding site [chemical binding]; other site 59922000233 Ultra-violet resistance protein B; Region: UvrB; pfam12344 59922000234 UvrB/uvrC motif; Region: UVR; pfam02151 59922000235 aspartate kinase; Provisional; Region: PRK07431 59922000236 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 59922000237 putative nucleotide binding site [chemical binding]; other site 59922000238 putative catalytic residues [active] 59922000239 putative Mg ion binding site [ion binding]; other site 59922000240 putative aspartate binding site [chemical binding]; other site 59922000241 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 59922000242 putative allosteric regulatory site; other site 59922000243 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 59922000244 putative allosteric regulatory residue; other site 59922000245 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 59922000246 putative allosteric regulatory site; other site 59922000247 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 59922000248 putative allosteric regulatory residue; other site 59922000249 DNA polymerase III subunit delta; Validated; Region: PRK07452 59922000250 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 59922000251 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 59922000252 Precorrin-8X methylmutase; Region: CbiC; pfam02570 59922000253 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 59922000254 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 59922000255 HlyD family secretion protein; Region: HlyD_3; pfam13437 59922000256 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 59922000257 ligand binding site [chemical binding]; other site 59922000258 flexible hinge region; other site 59922000259 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 59922000260 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259 59922000261 putative active site [active] 59922000262 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 59922000263 ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249 59922000264 Walker A/P-loop; other site 59922000265 ATP binding site [chemical binding]; other site 59922000266 Q-loop/lid; other site 59922000267 ABC transporter signature motif; other site 59922000268 Walker B; other site 59922000269 D-loop; other site 59922000270 H-loop/switch region; other site 59922000271 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 59922000272 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 59922000273 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 59922000274 MutS domain I; Region: MutS_I; pfam01624 59922000275 MutS domain II; Region: MutS_II; pfam05188 59922000276 MutS domain III; Region: MutS_III; pfam05192 59922000277 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 59922000278 Walker A/P-loop; other site 59922000279 ATP binding site [chemical binding]; other site 59922000280 Q-loop/lid; other site 59922000281 ABC transporter signature motif; other site 59922000282 Walker B; other site 59922000283 D-loop; other site 59922000284 H-loop/switch region; other site 59922000285 photosystem II core protein PsbZ; Region: PS_II_psbZ; TIGR03043 59922000286 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 59922000287 homopentamer interface [polypeptide binding]; other site 59922000288 active site 59922000289 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 59922000290 Coenzyme A binding pocket [chemical binding]; other site 59922000291 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 59922000292 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 59922000293 active site 59922000294 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 59922000295 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 59922000296 NADP binding site [chemical binding]; other site 59922000297 active site 59922000298 putative substrate binding site [chemical binding]; other site 59922000299 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 59922000300 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 59922000301 active site 59922000302 motif I; other site 59922000303 motif II; other site 59922000304 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 59922000305 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 59922000306 active site 59922000307 Substrate binding site; other site 59922000308 Mg++ binding site; other site 59922000309 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 59922000310 dimer interface [polypeptide binding]; other site 59922000311 active site 59922000312 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 59922000313 active site 59922000314 nucleotide binding site [chemical binding]; other site 59922000315 HIGH motif; other site 59922000316 KMSKS motif; other site 59922000317 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 59922000318 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 59922000319 putative ribose interaction site [chemical binding]; other site 59922000320 putative ADP binding site [chemical binding]; other site 59922000321 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 59922000322 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 59922000323 NAD(P) binding site [chemical binding]; other site 59922000324 active site 59922000325 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 59922000326 Radical SAM superfamily; Region: Radical_SAM; pfam04055 59922000327 FeS/SAM binding site; other site 59922000328 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 59922000329 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 59922000330 tetramer interface [polypeptide binding]; other site 59922000331 TPP-binding site [chemical binding]; other site 59922000332 heterodimer interface [polypeptide binding]; other site 59922000333 phosphorylation loop region [posttranslational modification] 59922000334 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 59922000335 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 59922000336 PYR/PP interface [polypeptide binding]; other site 59922000337 dimer interface [polypeptide binding]; other site 59922000338 TPP binding site [chemical binding]; other site 59922000339 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 59922000340 Radical SAM superfamily; Region: Radical_SAM; pfam04055 59922000341 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 59922000342 FeS/SAM binding site; other site 59922000343 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 59922000344 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 59922000345 substrate binding site [chemical binding]; other site 59922000346 glutamase interaction surface [polypeptide binding]; other site 59922000347 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 59922000348 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 59922000349 putative active site [active] 59922000350 oxyanion strand; other site 59922000351 catalytic triad [active] 59922000352 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_III; cd01996 59922000353 Ligand Binding Site [chemical binding]; other site 59922000354 UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568 59922000355 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 59922000356 active site 59922000357 homodimer interface [polypeptide binding]; other site 59922000358 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 59922000359 NeuB family; Region: NeuB; pfam03102 59922000360 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 59922000361 NeuB binding interface [polypeptide binding]; other site 59922000362 putative substrate binding site [chemical binding]; other site 59922000363 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 59922000364 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 59922000365 putative trimer interface [polypeptide binding]; other site 59922000366 putative CoA binding site [chemical binding]; other site 59922000367 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 59922000368 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 59922000369 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 59922000370 catalytic residue [active] 59922000371 NAD dependent epimerase/dehydratase, LLPSF_EDH_00030 family; Region: EDH_00030; TIGR04180 59922000372 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 59922000373 NAD binding site [chemical binding]; other site 59922000374 substrate binding site [chemical binding]; other site 59922000375 active site 59922000376 flagellin modification protein A; Provisional; Region: PRK09186 59922000377 classical (c) SDR, subgroup 8; Region: SDR_c8; cd08930 59922000378 putative NAD(P) binding site [chemical binding]; other site 59922000379 active site 59922000380 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 59922000381 ligand binding site; other site 59922000382 tetramer interface; other site 59922000383 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 59922000384 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 59922000385 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 59922000386 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 59922000387 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 59922000388 NTP_trnasferase_like_2 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_2; cd06426 59922000389 Substrate binding site; other site 59922000390 metal-binding site 59922000391 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 59922000392 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 59922000393 NAD binding site [chemical binding]; other site 59922000394 substrate binding site [chemical binding]; other site 59922000395 homodimer interface [polypeptide binding]; other site 59922000396 active site 59922000397 Protein of unknown function DUF115; Region: MAF_flag10; pfam01973 59922000398 Protein of unknown function DUF115; Region: MAF_flag10; pfam01973 59922000399 Protein of unknown function DUF115; Region: MAF_flag10; pfam01973 59922000400 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 59922000401 This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818 59922000402 putative ADP-binding pocket [chemical binding]; other site 59922000403 This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818 59922000404 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 59922000405 putative ADP-binding pocket [chemical binding]; other site 59922000406 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 59922000407 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 59922000408 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 59922000409 ligand binding site [chemical binding]; other site 59922000410 flexible hinge region; other site 59922000411 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 59922000412 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259 59922000413 putative active site [active] 59922000414 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 59922000415 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 59922000416 Walker A/P-loop; other site 59922000417 ATP binding site [chemical binding]; other site 59922000418 Q-loop/lid; other site 59922000419 ABC transporter signature motif; other site 59922000420 Walker B; other site 59922000421 D-loop; other site 59922000422 H-loop/switch region; other site 59922000423 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 59922000424 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 59922000425 HlyD family secretion protein; Region: HlyD_3; pfam13437 59922000426 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 59922000427 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 59922000428 Sulfatase; Region: Sulfatase; cl17466 59922000429 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 59922000430 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3551 59922000431 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 59922000432 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 59922000433 active site 59922000434 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 59922000435 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 59922000436 Walker A/P-loop; other site 59922000437 ATP binding site [chemical binding]; other site 59922000438 Q-loop/lid; other site 59922000439 ABC transporter signature motif; other site 59922000440 Walker B; other site 59922000441 D-loop; other site 59922000442 H-loop/switch region; other site 59922000443 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 59922000444 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 59922000445 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 59922000446 substrate binding site; other site 59922000447 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 59922000448 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 59922000449 NAD(P) binding site [chemical binding]; other site 59922000450 active site 59922000451 lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407 59922000452 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 59922000453 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 59922000454 catalytic residue [active] 59922000455 acetoacetyl-CoA reductase; Provisional; Region: PRK12824 59922000456 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 59922000457 classical (c) SDRs; Region: SDR_c; cd05233 59922000458 NAD(P) binding site [chemical binding]; other site 59922000459 active site 59922000460 Dehydroquinate synthase (DHQS)-like. DHQS catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS-like1; cd08196 59922000461 putative active site [active] 59922000462 metal binding site [ion binding]; metal-binding site 59922000463 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 59922000464 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 59922000465 TPP binding site [chemical binding]; other site 59922000466 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 59922000467 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 59922000468 TPP-binding site [chemical binding]; other site 59922000469 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 59922000470 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 59922000471 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 59922000472 active site 59922000473 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 59922000474 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 59922000475 active site 59922000476 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 59922000477 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 59922000478 active site 59922000479 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 59922000480 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12902 59922000481 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 59922000482 ATP binding site [chemical binding]; other site 59922000483 putative Mg++ binding site [ion binding]; other site 59922000484 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 59922000485 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 59922000486 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 59922000487 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 59922000488 trimer interface [polypeptide binding]; other site 59922000489 active site 59922000490 substrate binding site [chemical binding]; other site 59922000491 CoA binding site [chemical binding]; other site 59922000492 Predicted transcriptional regulators [Transcription]; Region: COG1725 59922000493 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 59922000494 DNA-binding site [nucleotide binding]; DNA binding site 59922000495 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 59922000496 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 59922000497 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 59922000498 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 59922000499 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 59922000500 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 59922000501 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 59922000502 Mg2+ binding site [ion binding]; other site 59922000503 G-X-G motif; other site 59922000504 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 59922000505 anchoring element; other site 59922000506 dimer interface [polypeptide binding]; other site 59922000507 ATP binding site [chemical binding]; other site 59922000508 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 59922000509 active site 59922000510 putative metal-binding site [ion binding]; other site 59922000511 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 59922000512 CrcB-like protein; Region: CRCB; pfam02537 59922000513 CrcB-like protein; Region: CRCB; pfam02537 59922000514 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 59922000515 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 59922000516 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 59922000517 catalytic residues [active] 59922000518 dimer interface [polypeptide binding]; other site 59922000519 Mg2+ transporter (mgtE); Region: mgtE; TIGR00400 59922000520 MgtE intracellular N domain; Region: MgtE_N; smart00924 59922000521 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 59922000522 Divalent cation transporter; Region: MgtE; pfam01769 59922000523 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 59922000524 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 59922000525 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 59922000526 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 59922000527 Sigma-70, region 4; Region: Sigma70_r4; pfam04545 59922000528 DNA binding residues [nucleotide binding] 59922000529 hydrolase, alpha/beta fold family protein; Region: PLN02824 59922000530 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 59922000531 Protein export membrane protein; Region: SecD_SecF; cl14618 59922000532 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 59922000533 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 59922000534 HlyD family secretion protein; Region: HlyD_3; pfam13437 59922000535 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 59922000536 putative Iron-sulfur protein interface [polypeptide binding]; other site 59922000537 proximal heme binding site [chemical binding]; other site 59922000538 distal heme binding site [chemical binding]; other site 59922000539 putative dimer interface [polypeptide binding]; other site 59922000540 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 59922000541 L-aspartate oxidase; Provisional; Region: PRK06175 59922000542 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 59922000543 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 59922000544 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 59922000545 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 59922000546 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 59922000547 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 59922000548 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 59922000549 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 59922000550 minor groove reading motif; other site 59922000551 helix-hairpin-helix signature motif; other site 59922000552 substrate binding pocket [chemical binding]; other site 59922000553 active site 59922000554 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 59922000555 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 59922000556 active site 59922000557 8-oxo-dGMP binding site [chemical binding]; other site 59922000558 nudix motif; other site 59922000559 metal binding site [ion binding]; metal-binding site 59922000560 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 59922000561 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 59922000562 putative substrate binding site [chemical binding]; other site 59922000563 putative ATP binding site [chemical binding]; other site 59922000564 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 59922000565 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 59922000566 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 59922000567 homotetramer interface [polypeptide binding]; other site 59922000568 ligand binding site [chemical binding]; other site 59922000569 catalytic site [active] 59922000570 NAD binding site [chemical binding]; other site 59922000571 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 59922000572 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 59922000573 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 59922000574 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 59922000575 dimer interface [polypeptide binding]; other site 59922000576 ssDNA binding site [nucleotide binding]; other site 59922000577 tetramer (dimer of dimers) interface [polypeptide binding]; other site 59922000578 rod shape-determining protein MreB; Provisional; Region: PRK13927 59922000579 MreB and similar proteins; Region: MreB_like; cd10225 59922000580 nucleotide binding site [chemical binding]; other site 59922000581 Mg binding site [ion binding]; other site 59922000582 putative protofilament interaction site [polypeptide binding]; other site 59922000583 RodZ interaction site [polypeptide binding]; other site 59922000584 rod shape-determining protein MreC; Provisional; Region: PRK13922 59922000585 rod shape-determining protein MreC; Region: MreC; pfam04085 59922000586 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 59922000587 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 59922000588 Ycf27; Reviewed; Region: orf27; CHL00148 59922000589 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 59922000590 active site 59922000591 phosphorylation site [posttranslational modification] 59922000592 intermolecular recognition site; other site 59922000593 dimerization interface [polypeptide binding]; other site 59922000594 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 59922000595 DNA binding site [nucleotide binding] 59922000596 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 59922000597 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 59922000598 dimer interface [polypeptide binding]; other site 59922000599 putative anticodon binding site; other site 59922000600 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 59922000601 motif 1; other site 59922000602 active site 59922000603 motif 2; other site 59922000604 motif 3; other site 59922000605 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 59922000606 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 59922000607 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 59922000608 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 59922000609 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 59922000610 Protein kinase domain; Region: Pkinase; pfam00069 59922000611 active site 59922000612 ATP binding site [chemical binding]; other site 59922000613 substrate binding site [chemical binding]; other site 59922000614 activation loop (A-loop); other site 59922000615 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 59922000616 SmpB-tmRNA interface; other site 59922000617 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 59922000618 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 59922000619 Walker A motif; other site 59922000620 ATP binding site [chemical binding]; other site 59922000621 Walker B motif; other site 59922000622 arginine finger; other site 59922000623 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 59922000624 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922000625 TPR repeat; Region: TPR_11; pfam13414 59922000626 binding surface 59922000627 TPR motif; other site 59922000628 TPR repeat; Region: TPR_11; pfam13414 59922000629 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922000630 binding surface 59922000631 TPR motif; other site 59922000632 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 59922000633 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 59922000634 metal binding site [ion binding]; metal-binding site 59922000635 dimer interface [polypeptide binding]; other site 59922000636 Protein of unknown function (DUF3188); Region: DUF3188; pfam11384 59922000637 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 59922000638 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 59922000639 Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862 59922000640 Protein of unknown function (DUF1499); Region: DUF1499; pfam07386 59922000641 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 59922000642 shikimate kinase; Reviewed; Region: aroK; PRK00131 59922000643 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 59922000644 ADP binding site [chemical binding]; other site 59922000645 magnesium binding site [ion binding]; other site 59922000646 putative shikimate binding site; other site 59922000647 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 59922000648 active site 59922000649 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 59922000650 active site 59922000651 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 59922000652 RibD C-terminal domain; Region: RibD_C; cl17279 59922000653 Protein phosphatase 2A homologues, catalytic domain; Region: PP2Ac; smart00156 59922000654 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 59922000655 Protein of unknown function, DUF482; Region: DUF482; pfam04339 59922000656 Domain of unknown function (DUF4346); Region: DUF4346; pfam14251 59922000657 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 59922000658 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 59922000659 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 59922000660 FeS/SAM binding site; other site 59922000661 Domain of unknown function (DUF4070); Region: DUF4070; pfam13282 59922000662 Transmembrane secretion effector; Region: MFS_3; pfam05977 59922000663 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 59922000664 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 59922000665 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 59922000666 FeS/SAM binding site; other site 59922000667 Vitamin K epoxide reductase family in bacteria and plants; Region: VKOR_1; cd12916 59922000668 substrate binding site [chemical binding]; other site 59922000669 putative active site [active] 59922000670 redox center [active] 59922000671 Protein Disulfide Isomerase (PDIa) family, redox active TRX domains; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family include PDI...; Region: PDI_a_family; cd02961 59922000672 catalytic residues [active] 59922000673 L-aspartate oxidase; Provisional; Region: PRK07395 59922000674 L-aspartate oxidase; Provisional; Region: PRK06175 59922000675 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 59922000676 photosystem II complex extrinsic protein precursor U; Provisional; Region: psbU; PRK02515 59922000677 Protein of unknown function (DUF3120); Region: DUF3120; pfam11318 59922000678 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 59922000679 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 59922000680 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 59922000681 Protein of unknown function (DUF512); Region: DUF512; pfam04459 59922000682 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 59922000683 Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643 59922000684 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 59922000685 active site 59922000686 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 59922000687 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 59922000688 Exonuclease VII small subunit; Region: Exonuc_VII_S; pfam02609 59922000689 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 59922000690 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 59922000691 generic binding surface II; other site 59922000692 generic binding surface I; other site 59922000693 light-harvesting-like protein 3; Provisional; Region: PLN00014 59922000694 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 59922000695 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 59922000696 ATP binding site [chemical binding]; other site 59922000697 putative Mg++ binding site [ion binding]; other site 59922000698 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 59922000699 nucleotide binding region [chemical binding]; other site 59922000700 ATP-binding site [chemical binding]; other site 59922000701 Helicase associated domain (HA2); Region: HA2; pfam04408 59922000702 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 59922000703 Protein of unknown function (DUF2973); Region: DUF2973; pfam11189 59922000704 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 59922000705 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 59922000706 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 59922000707 protein binding site [polypeptide binding]; other site 59922000708 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 59922000709 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 59922000710 Walker A/P-loop; other site 59922000711 ATP binding site [chemical binding]; other site 59922000712 Q-loop/lid; other site 59922000713 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 59922000714 ABC transporter; Region: ABC_tran_2; pfam12848 59922000715 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 59922000716 ABC transporter; Region: ABC_tran_2; pfam12848 59922000717 type IV secretion system ATPase VirB11; Provisional; Region: PRK13900 59922000718 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 59922000719 Protein of unknown function (DUF1662); Region: DUF1662; pfam07878 59922000720 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 59922000721 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 59922000722 TrkA-N domain; Region: TrkA_N; pfam02254 59922000723 TrkA-C domain; Region: TrkA_C; pfam02080 59922000724 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 59922000725 Cation transport protein; Region: TrkH; pfam02386 59922000726 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 59922000727 transmembrane helices; other site 59922000728 TrkA-C domain; Region: TrkA_C; pfam02080 59922000729 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 59922000730 TrkA-C domain; Region: TrkA_C; pfam02080 59922000731 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 59922000732 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 59922000733 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 59922000734 HflX GTPase family; Region: HflX; cd01878 59922000735 G1 box; other site 59922000736 GTP/Mg2+ binding site [chemical binding]; other site 59922000737 Switch I region; other site 59922000738 G2 box; other site 59922000739 G3 box; other site 59922000740 Switch II region; other site 59922000741 G4 box; other site 59922000742 G5 box; other site 59922000743 pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169 59922000744 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 59922000745 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 59922000746 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 59922000747 Active Sites [active] 59922000748 Type III pantothenate kinase; Region: Pan_kinase; cl17198 59922000749 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 59922000750 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 59922000751 catalytic triad [active] 59922000752 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 59922000753 recombination factor protein RarA/unknown domain fusion protein; Reviewed; Region: PRK13341 59922000754 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 59922000755 Walker A motif; other site 59922000756 ATP binding site [chemical binding]; other site 59922000757 Walker B motif; other site 59922000758 arginine finger; other site 59922000759 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 59922000760 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 59922000761 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 59922000762 carboxyltransferase (CT) interaction site; other site 59922000763 biotinylation site [posttranslational modification]; other site 59922000764 HlyD family secretion protein; Region: HlyD_3; pfam13437 59922000765 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 59922000766 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 59922000767 phosphoglucomutase; Region: PLN02307 59922000768 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 59922000769 active site 59922000770 substrate binding site [chemical binding]; other site 59922000771 metal binding site [ion binding]; metal-binding site 59922000772 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 59922000773 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 59922000774 TPR repeat; Region: TPR_11; pfam13414 59922000775 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922000776 TPR motif; other site 59922000777 binding surface 59922000778 TPR repeat; Region: TPR_11; pfam13414 59922000779 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922000780 TPR motif; other site 59922000781 binding surface 59922000782 TPR repeat; Region: TPR_11; pfam13414 59922000783 Methyltransferase domain; Region: Methyltransf_31; pfam13847 59922000784 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 59922000785 S-adenosylmethionine binding site [chemical binding]; other site 59922000786 PLD-like domain; Region: PLDc_2; pfam13091 59922000787 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 59922000788 putative active site [active] 59922000789 tungsten cofactor oxidoreducase radical SAM maturase; Region: W_rSAM_matur; TIGR04317 59922000790 Putative methyltransferase; Region: Methyltransf_4; cl17290 59922000791 Methyltransferase domain; Region: Methyltransf_23; pfam13489 59922000792 Methyltransferase domain; Region: Methyltransf_12; pfam08242 59922000793 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 59922000794 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922000795 binding surface 59922000796 TPR motif; other site 59922000797 TPR repeat; Region: TPR_11; pfam13414 59922000798 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922000799 binding surface 59922000800 TPR repeat; Region: TPR_11; pfam13414 59922000801 TPR motif; other site 59922000802 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 59922000803 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922000804 binding surface 59922000805 TPR motif; other site 59922000806 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922000807 binding surface 59922000808 TPR motif; other site 59922000809 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 59922000810 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922000811 Tetratricopeptide repeat; Region: TPR_12; pfam13424 59922000812 TPR motif; other site 59922000813 binding surface 59922000814 Tetratricopeptide repeat; Region: TPR_16; pfam13432 59922000815 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922000816 TPR motif; other site 59922000817 binding surface 59922000818 PLD-like domain; Region: PLDc_2; pfam13091 59922000819 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 59922000820 putative active site [active] 59922000821 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 59922000822 active site 59922000823 Int/Topo IB signature motif; other site 59922000824 DNA binding site [nucleotide binding] 59922000825 DNA primase; Provisional; Region: 61; PHA02540 59922000826 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922000827 binding surface 59922000828 TPR motif; other site 59922000829 TPR repeat; Region: TPR_11; pfam13414 59922000830 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922000831 binding surface 59922000832 TPR motif; other site 59922000833 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 59922000834 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922000835 binding surface 59922000836 TPR motif; other site 59922000837 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922000838 binding surface 59922000839 TPR motif; other site 59922000840 Tetratricopeptide repeat; Region: TPR_1; pfam00515 59922000841 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922000842 binding surface 59922000843 TPR motif; other site 59922000844 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922000845 binding surface 59922000846 TPR motif; other site 59922000847 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922000848 binding surface 59922000849 TPR motif; other site 59922000850 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922000851 binding surface 59922000852 TPR motif; other site 59922000853 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922000854 binding surface 59922000855 TPR motif; other site 59922000856 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922000857 binding surface 59922000858 TPR motif; other site 59922000859 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 59922000860 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922000861 binding surface 59922000862 TPR motif; other site 59922000863 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922000864 binding surface 59922000865 TPR motif; other site 59922000866 Tetratricopeptide repeat; Region: TPR_16; pfam13432 59922000867 Methyltransferase domain; Region: Methyltransf_31; pfam13847 59922000868 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 59922000869 S-adenosylmethionine binding site [chemical binding]; other site 59922000870 Putative catalytic domain, repeat 2, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_2; cd09173 59922000871 PLD-like domain; Region: PLDc_2; pfam13091 59922000872 putative active site [active] 59922000873 catalytic site [active] 59922000874 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 59922000875 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922000876 binding surface 59922000877 TPR motif; other site 59922000878 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922000879 binding surface 59922000880 TPR motif; other site 59922000881 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922000882 binding surface 59922000883 TPR motif; other site 59922000884 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922000885 binding surface 59922000886 TPR motif; other site 59922000887 Putative 2OG-Fe(II) oxygenase; Region: 2OG-FeII_Oxy_5; pfam13759 59922000888 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 59922000889 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 59922000890 putative active site [active] 59922000891 catalytic site [active] 59922000892 Putative catalytic domain, repeat 2, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_2; cd09173 59922000893 putative active site [active] 59922000894 catalytic site [active] 59922000895 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 59922000896 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 59922000897 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 59922000898 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 59922000899 putative DNA binding site [nucleotide binding]; other site 59922000900 iron-sulfur cluster biosynthesis transcriptional regulator SufR; Region: SufR_cyano; TIGR02702 59922000901 putative Zn2+ binding site [ion binding]; other site 59922000902 Transcriptional regulator PadR-like family; Region: PadR; cl17335 59922000903 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 59922000904 putative ABC transporter; Region: ycf24; CHL00085 59922000905 sulfate ABC transporter protein; Validated; Region: ycf16; CHL00131 59922000906 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 59922000907 Walker A/P-loop; other site 59922000908 ATP binding site [chemical binding]; other site 59922000909 Q-loop/lid; other site 59922000910 ABC transporter signature motif; other site 59922000911 Walker B; other site 59922000912 D-loop; other site 59922000913 H-loop/switch region; other site 59922000914 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 59922000915 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 59922000916 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 59922000917 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 59922000918 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 59922000919 catalytic residue [active] 59922000920 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 59922000921 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 59922000922 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 59922000923 active site 59922000924 catalytic residues [active] 59922000925 metal binding site [ion binding]; metal-binding site 59922000926 Protein of unknown function (DUF3747); Region: DUF3747; pfam12565 59922000927 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 59922000928 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 59922000929 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 59922000930 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 59922000931 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 59922000932 nucleotide binding site/active site [active] 59922000933 HIT family signature motif; other site 59922000934 catalytic residue [active] 59922000935 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 59922000936 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 59922000937 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 59922000938 Chlorophyll A-B binding protein; Region: Chloroa_b-bind; cl02879 59922000939 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 59922000940 bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507 59922000941 Ycf66 protein N-terminus; Region: Ycf66_N; pfam07444 59922000942 Photosystem II reaction centre X protein (PsbX); Region: PsbX; cl05887 59922000943 YGGT family; Region: YGGT; pfam02325 59922000944 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 59922000945 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 59922000946 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 59922000947 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 59922000948 Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763 59922000949 methionine sulfoxide reductase B; Provisional; Region: PRK00222 59922000950 SelR domain; Region: SelR; pfam01641 59922000951 PRC-barrel domain; Region: PRC; pfam05239 59922000952 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 59922000953 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 59922000954 Walker A/P-loop; other site 59922000955 ATP binding site [chemical binding]; other site 59922000956 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 59922000957 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 59922000958 Q-loop/lid; other site 59922000959 ABC transporter signature motif; other site 59922000960 Walker B; other site 59922000961 D-loop; other site 59922000962 H-loop/switch region; other site 59922000963 DNA polymerase Ligase (LigD); Region: LigD_N; pfam13298 59922000964 Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862 59922000965 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 59922000966 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 59922000967 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 59922000968 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 59922000969 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 59922000970 CHASE2 domain; Region: CHASE2; pfam05226 59922000971 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 59922000972 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 59922000973 cyclase homology domain; Region: CHD; cd07302 59922000974 nucleotidyl binding site; other site 59922000975 metal binding site [ion binding]; metal-binding site 59922000976 dimer interface [polypeptide binding]; other site 59922000977 CHAT domain; Region: CHAT; cl17868 59922000978 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 59922000979 active site 59922000980 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 59922000981 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 59922000982 Nitrogen fixation protein of unknown function; Region: Nif11; cl06756 59922000983 Nitrogen fixation protein of unknown function; Region: Nif11; cl06756 59922000984 Protein of unknown function (DUF805); Region: DUF805; pfam05656 59922000985 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 59922000986 Cytochrome P450; Region: p450; cl12078 59922000987 Cytochrome P450; Region: p450; cl12078 59922000988 Cupin superfamily (DUF985); Region: Cupin_5; cl01418 59922000989 Staphylococcal nuclease homologues; Region: SNc; smart00318 59922000990 Catalytic site; other site 59922000991 Staphylococcal nuclease homologue; Region: SNase; pfam00565 59922000992 Short C-terminal domain; Region: SHOCT; pfam09851 59922000993 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 59922000994 carotene isomerase; Region: carot_isom; TIGR02730 59922000995 NADPH-dependent glutamate synthase beta chain and related oxidoreductases [Amino acid transport and metabolism / General function prediction only]; Region: GltD; COG0493 59922000996 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 59922000997 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 59922000998 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 59922000999 active site 59922001000 metal binding site [ion binding]; metal-binding site 59922001001 hexamer interface [polypeptide binding]; other site 59922001002 Lecithin:cholesterol acyltransferase; Region: LACT; pfam02450 59922001003 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 59922001004 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 59922001005 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 59922001006 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 59922001007 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 59922001008 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 59922001009 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 59922001010 chaperone protein DnaJ; Provisional; Region: PRK14299 59922001011 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 59922001012 HSP70 interaction site [polypeptide binding]; other site 59922001013 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 59922001014 substrate binding site [polypeptide binding]; other site 59922001015 dimer interface [polypeptide binding]; other site 59922001016 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 59922001017 dimer interface [polypeptide binding]; other site 59922001018 active site 59922001019 aspartate-rich active site metal binding site; other site 59922001020 allosteric magnesium binding site [ion binding]; other site 59922001021 Schiff base residues; other site 59922001022 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 59922001023 MutS domain III; Region: MutS_III; pfam05192 59922001024 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 59922001025 Walker A/P-loop; other site 59922001026 ATP binding site [chemical binding]; other site 59922001027 Q-loop/lid; other site 59922001028 ABC transporter signature motif; other site 59922001029 Walker B; other site 59922001030 D-loop; other site 59922001031 H-loop/switch region; other site 59922001032 Smr domain; Region: Smr; pfam01713 59922001033 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 59922001034 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 59922001035 Walker A/P-loop; other site 59922001036 ATP binding site [chemical binding]; other site 59922001037 Q-loop/lid; other site 59922001038 ABC transporter signature motif; other site 59922001039 Walker B; other site 59922001040 D-loop; other site 59922001041 H-loop/switch region; other site 59922001042 TOBE domain; Region: TOBE_2; pfam08402 59922001043 nif11-like leader peptide domain; Region: ocin_TIGR03798 59922001044 nif11-like leader peptide domain; Region: ocin_TIGR03798 59922001045 nif11-like leader peptide domain; Region: ocin_TIGR03798 59922001046 GTPase CgtA; Reviewed; Region: obgE; PRK12299 59922001047 GTP1/OBG; Region: GTP1_OBG; pfam01018 59922001048 Obg GTPase; Region: Obg; cd01898 59922001049 G1 box; other site 59922001050 GTP/Mg2+ binding site [chemical binding]; other site 59922001051 Switch I region; other site 59922001052 G2 box; other site 59922001053 G3 box; other site 59922001054 Switch II region; other site 59922001055 G4 box; other site 59922001056 G5 box; other site 59922001057 plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454 59922001058 CP12 domain; Region: CP12; pfam02672 59922001059 Uncharacterized conserved protein (DUF2348); Region: DUF2348; pfam09807 59922001060 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 59922001061 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 59922001062 Walker A/P-loop; other site 59922001063 ATP binding site [chemical binding]; other site 59922001064 Q-loop/lid; other site 59922001065 ABC transporter signature motif; other site 59922001066 Walker B; other site 59922001067 D-loop; other site 59922001068 H-loop/switch region; other site 59922001069 ABC transporter; Region: ABC_tran_2; pfam12848 59922001070 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 59922001071 Uncharacterized integral membrane protein (DUF2301); Region: DUF2301; pfam10063 59922001072 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 59922001073 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 59922001074 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 59922001075 putative dimer interface [polypeptide binding]; other site 59922001076 N-terminal domain interface [polypeptide binding]; other site 59922001077 putative substrate binding pocket (H-site) [chemical binding]; other site 59922001078 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 59922001079 Peptidase M14 Aspartoacylase (ASPA) subfamily; Region: M14_ASPA; cd06909 59922001080 active site 59922001081 Zn binding site [ion binding]; other site 59922001082 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 59922001083 protein I interface; other site 59922001084 D2 interface; other site 59922001085 protein T interface; other site 59922001086 chlorophyll binding site; other site 59922001087 beta carotene binding site; other site 59922001088 pheophytin binding site; other site 59922001089 manganese-stabilizing polypeptide interface; other site 59922001090 CP43 interface; other site 59922001091 protein L interface; other site 59922001092 oxygen evolving complex binding site; other site 59922001093 bromide binding site; other site 59922001094 quinone binding site; other site 59922001095 Fe binding site [ion binding]; other site 59922001096 core light harvesting interface; other site 59922001097 cytochrome b559 alpha subunit interface; other site 59922001098 cytochrome c-550 interface; other site 59922001099 protein J interface; other site 59922001100 Domain of unknown function (DUF389); Region: DUF389; pfam04087 59922001101 translation initiation factor IF-2; Region: IF-2; TIGR00487 59922001102 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 59922001103 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 59922001104 G1 box; other site 59922001105 putative GEF interaction site [polypeptide binding]; other site 59922001106 GTP/Mg2+ binding site [chemical binding]; other site 59922001107 Switch I region; other site 59922001108 G2 box; other site 59922001109 G3 box; other site 59922001110 Switch II region; other site 59922001111 G4 box; other site 59922001112 G5 box; other site 59922001113 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 59922001114 Translation-initiation factor 2; Region: IF-2; pfam11987 59922001115 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 59922001116 Protein of unknown function (DUF448); Region: DUF448; pfam04296 59922001117 putative RNA binding cleft [nucleotide binding]; other site 59922001118 transcription elongation factor NusA; Provisional; Region: nusA; PRK12329 59922001119 NusA N-terminal domain; Region: NusA_N; pfam08529 59922001120 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 59922001121 RNA binding site [nucleotide binding]; other site 59922001122 homodimer interface [polypeptide binding]; other site 59922001123 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 59922001124 G-X-X-G motif; other site 59922001125 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 59922001126 G-X-X-G motif; other site 59922001127 hypothetical protein; Provisional; Region: PRK14634 59922001128 ribosome maturation protein RimP; Reviewed; Region: PRK00092 59922001129 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 59922001130 Mechanosensitive ion channel; Region: MS_channel; pfam00924 59922001131 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 59922001132 Uncharacterized conserved protein [Function unknown]; Region: COG5361 59922001133 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 59922001134 Protein of unknown function (DUF1214); Region: DUF1214; pfam06742 59922001135 Uncharacterized conserved protein [Function unknown]; Region: COG5361 59922001136 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 59922001137 Protein of unknown function (DUF1214); Region: DUF1214; pfam06742 59922001138 radical SAM/SPASM domain protein, GRRM system; Region: rSAM_GlyRichRpt; TIGR04261 59922001139 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 59922001140 FeS/SAM binding site; other site 59922001141 rSAM-associated Gly-rich repeat protein; Region: Cyano_gly_rpt; TIGR04260 59922001142 rSAM-associated Gly-rich repeat protein; Region: Cyano_gly_rpt; TIGR04260 59922001143 extracellular substrate-binding orphan protein, GRRM family; Region: orph_peri_GRRM; TIGR04262 59922001144 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 59922001145 substrate binding pocket [chemical binding]; other site 59922001146 membrane-bound complex binding site; other site 59922001147 hinge residues; other site 59922001148 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 59922001149 Uncharacterized conserved protein [Function unknown]; Region: COG1262 59922001150 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 59922001151 Sulfatase; Region: Sulfatase; pfam00884 59922001152 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 59922001153 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 59922001154 protein binding site [polypeptide binding]; other site 59922001155 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 59922001156 tetramer (dimer of dimers) interface [polypeptide binding]; other site 59922001157 active site 59922001158 dimer interface [polypeptide binding]; other site 59922001159 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 59922001160 histidinol dehydrogenase; Region: hisD; TIGR00069 59922001161 NAD binding site [chemical binding]; other site 59922001162 dimerization interface [polypeptide binding]; other site 59922001163 product binding site; other site 59922001164 substrate binding site [chemical binding]; other site 59922001165 zinc binding site [ion binding]; other site 59922001166 catalytic residues [active] 59922001167 ribosomal protein S20; Region: rps20; CHL00102 59922001168 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 59922001169 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 59922001170 active site 59922001171 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 59922001172 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 59922001173 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 59922001174 RPB1 interaction site [polypeptide binding]; other site 59922001175 RPB10 interaction site [polypeptide binding]; other site 59922001176 RPB11 interaction site [polypeptide binding]; other site 59922001177 RPB3 interaction site [polypeptide binding]; other site 59922001178 RPB12 interaction site [polypeptide binding]; other site 59922001179 DNA-directed RNA polymerase subunit gamma; Provisional; Region: rpoC1; PRK02625 59922001180 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 59922001181 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 59922001182 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 59922001183 DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597 59922001184 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 59922001185 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 59922001186 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 59922001187 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 59922001188 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 59922001189 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 59922001190 DNA binding site [nucleotide binding] 59922001191 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 59922001192 light-harvesting-like protein 3; Provisional; Region: PLN00014 59922001193 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14457 59922001194 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 59922001195 FeS/SAM binding site; other site 59922001196 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477 59922001197 Na binding site [ion binding]; other site 59922001198 HEAT repeats; Region: HEAT_2; pfam13646 59922001199 Protein of unknown function (DUF2997); Region: DUF2997; pfam11211 59922001200 Protein of unknown function (DUF1257); Region: DUF1257; pfam06868 59922001201 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 59922001202 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 59922001203 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 59922001204 active site 59922001205 catalytic tetrad [active] 59922001206 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 59922001207 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 59922001208 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 59922001209 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 59922001210 HSP70 interaction site [polypeptide binding]; other site 59922001211 Protein of unknown function (DUF3143); Region: DUF3143; pfam11341 59922001212 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 59922001213 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 59922001214 inhibitor-cofactor binding pocket; inhibition site 59922001215 pyridoxal 5'-phosphate binding site [chemical binding]; other site 59922001216 catalytic residue [active] 59922001217 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 59922001218 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 59922001219 AAA domain; Region: AAA_26; pfam13500 59922001220 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 59922001221 Methyltransferase domain; Region: Methyltransf_18; pfam12847 59922001222 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 59922001223 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 59922001224 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 59922001225 catalytic residue [active] 59922001226 DEAD-like helicases superfamily; Region: DEXDc; smart00487 59922001227 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 59922001228 ATP binding site [chemical binding]; other site 59922001229 putative Mg++ binding site [ion binding]; other site 59922001230 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 59922001231 nucleotide binding region [chemical binding]; other site 59922001232 ATP-binding site [chemical binding]; other site 59922001233 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 59922001234 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 59922001235 Major Facilitator Superfamily; Region: MFS_1; pfam07690 59922001236 putative substrate translocation pore; other site 59922001237 fumarate hydratase; Reviewed; Region: fumC; PRK00485 59922001238 Class II fumarases; Region: Fumarase_classII; cd01362 59922001239 active site 59922001240 tetramer interface [polypeptide binding]; other site 59922001241 adenylosuccinate lyase; Provisional; Region: PRK07380 59922001242 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 59922001243 tetramer interface [polypeptide binding]; other site 59922001244 active site 59922001245 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 59922001246 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 59922001247 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 59922001248 RNA binding surface [nucleotide binding]; other site 59922001249 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 59922001250 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 59922001251 Nitrogen regulatory protein P-II; Region: P-II; smart00938 59922001252 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 59922001253 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 59922001254 ResB-like family; Region: ResB; pfam05140 59922001255 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 59922001256 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 59922001257 Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098 59922001258 Methyltransferase domain; Region: Methyltransf_31; pfam13847 59922001259 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 59922001260 S-adenosylmethionine binding site [chemical binding]; other site 59922001261 ATP synthase I chain; Region: ATP_synt_I; pfam03899 59922001262 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 59922001263 ATP synthase CF0 A subunit; Region: atpI; CHL00046 59922001264 ATP synthase CF0 C subunit; Region: atpH; CHL00061 59922001265 F0F1 ATP synthase subunit B'; Validated; Region: PRK07353 59922001266 F0F1 ATP synthase subunit B; Validated; Region: PRK07352 59922001267 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 59922001268 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 59922001269 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13429 59922001270 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 59922001271 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 59922001272 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 59922001273 beta subunit interaction interface [polypeptide binding]; other site 59922001274 Walker A motif; other site 59922001275 ATP binding site [chemical binding]; other site 59922001276 Walker B motif; other site 59922001277 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 59922001278 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 59922001279 core domain interface [polypeptide binding]; other site 59922001280 delta subunit interface [polypeptide binding]; other site 59922001281 epsilon subunit interface [polypeptide binding]; other site 59922001282 Protein of unknown function (DUF3326); Region: DUF3326; pfam11805 59922001283 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 59922001284 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 59922001285 hexamer interface [polypeptide binding]; other site 59922001286 ligand binding site [chemical binding]; other site 59922001287 putative active site [active] 59922001288 NAD(P) binding site [chemical binding]; other site 59922001289 NAD synthetase; Provisional; Region: PRK13981 59922001290 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 59922001291 multimer interface [polypeptide binding]; other site 59922001292 active site 59922001293 catalytic triad [active] 59922001294 protein interface 1 [polypeptide binding]; other site 59922001295 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 59922001296 homodimer interface [polypeptide binding]; other site 59922001297 NAD binding pocket [chemical binding]; other site 59922001298 ATP binding pocket [chemical binding]; other site 59922001299 Mg binding site [ion binding]; other site 59922001300 active-site loop [active] 59922001301 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 59922001302 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 59922001303 active site 59922001304 (T/H)XGH motif; other site 59922001305 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 59922001306 G1 box; other site 59922001307 GTP/Mg2+ binding site [chemical binding]; other site 59922001308 Switch I region; other site 59922001309 G2 box; other site 59922001310 Switch II region; other site 59922001311 G3 box; other site 59922001312 G4 box; other site 59922001313 Domain of unknown function (DUF697); Region: DUF697; pfam05128 59922001314 Domain of unknown function DUF21; Region: DUF21; pfam01595 59922001315 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 59922001316 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 59922001317 proline aminopeptidase P II; Provisional; Region: PRK10879 59922001318 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 59922001319 active site 59922001320 nif11-like leader peptide domain; Region: ocin_TIGR03798 59922001321 haloacid dehalogenase superfamily, subfamily IA hydrolase, TIGR01548; Region: HAD-SF-IA-hyp1 59922001322 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 59922001323 hypothetical protein; Provisional; Region: PRK02724 59922001324 Class I aldolases; Region: Aldolase_Class_I; cl17187 59922001325 catalytic residue [active] 59922001326 ATP synthase CF1 epsilon subunit; Region: atpE; CHL00063 59922001327 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 59922001328 gamma subunit interface [polypeptide binding]; other site 59922001329 epsilon subunit interface [polypeptide binding]; other site 59922001330 LBP interface [polypeptide binding]; other site 59922001331 ATP synthase CF1 beta subunit; Region: atpB; CHL00060 59922001332 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 59922001333 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 59922001334 alpha subunit interaction interface [polypeptide binding]; other site 59922001335 Walker A motif; other site 59922001336 ATP binding site [chemical binding]; other site 59922001337 Walker B motif; other site 59922001338 inhibitor binding site; inhibition site 59922001339 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 59922001340 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 59922001341 oligomerisation interface [polypeptide binding]; other site 59922001342 mobile loop; other site 59922001343 roof hairpin; other site 59922001344 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 59922001345 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 59922001346 ring oligomerisation interface [polypeptide binding]; other site 59922001347 ATP/Mg binding site [chemical binding]; other site 59922001348 stacking interactions; other site 59922001349 hinge regions; other site 59922001350 phosphoglyceromutase; Provisional; Region: PRK05434 59922001351 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 59922001352 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 59922001353 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 59922001354 active site 59922001355 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 59922001356 nucleotide binding site [chemical binding]; other site 59922001357 putative NEF/HSP70 interaction site [polypeptide binding]; other site 59922001358 SBD interface [polypeptide binding]; other site 59922001359 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 59922001360 Domain of unknown function (DUF1818); Region: DUF1818; pfam08848 59922001361 Protein of unknown function (DUF2811); Region: DUF2811; pfam10929 59922001362 EVE domain; Region: EVE; cl00728 59922001363 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 59922001364 Membrane transport protein; Region: Mem_trans; cl09117 59922001365 Protein of unknown function (DUF4090); Region: DUF4090; pfam13319 59922001366 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02705 59922001367 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 59922001368 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 59922001369 photosystem II S4 domain protein; Region: PS_II_S4; TIGR03069 59922001370 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 59922001371 RNA binding surface [nucleotide binding]; other site 59922001372 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 59922001373 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 59922001374 ligand binding site [chemical binding]; other site 59922001375 NAD binding site [chemical binding]; other site 59922001376 dimerization interface [polypeptide binding]; other site 59922001377 catalytic site [active] 59922001378 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 59922001379 putative L-serine binding site [chemical binding]; other site 59922001380 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 59922001381 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 59922001382 S-adenosylmethionine binding site [chemical binding]; other site 59922001383 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 59922001384 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 59922001385 catalytic loop [active] 59922001386 iron binding site [ion binding]; other site 59922001387 cytochrome c-550; Provisional; Region: psbV; PRK13617 59922001388 ribonuclease Z; Region: RNase_Z; TIGR02651 59922001389 Stage II sporulation protein; Region: SpoIID; pfam08486 59922001390 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 59922001391 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 59922001392 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 59922001393 active site 59922001394 trimer interface [polypeptide binding]; other site 59922001395 allosteric site; other site 59922001396 active site lid [active] 59922001397 hexamer (dimer of trimers) interface [polypeptide binding]; other site 59922001398 hypothetical protein; Validated; Region: PRK00110 59922001399 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02755 59922001400 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 59922001401 RNA binding site [nucleotide binding]; other site 59922001402 active site 59922001403 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 59922001404 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 59922001405 ribosomal protein L21; Region: rpl21; CHL00075 59922001406 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 59922001407 tetramer interface [polypeptide binding]; other site 59922001408 dimer interface [polypeptide binding]; other site 59922001409 circadian clock protein KaiC; Region: circ_KaiC; TIGR02655 59922001410 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 59922001411 KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124 59922001412 Walker A motif; other site 59922001413 Walker A motif; other site 59922001414 ATP binding site [chemical binding]; other site 59922001415 Walker B motif; other site 59922001416 recA bacterial DNA recombination protein; Region: RecA; cl17211 59922001417 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 59922001418 Walker A motif; other site 59922001419 ATP binding site [chemical binding]; other site 59922001420 Walker B motif; other site 59922001421 HAMP domain; Region: HAMP; pfam00672 59922001422 dimerization interface [polypeptide binding]; other site 59922001423 PAS domain; Region: PAS; smart00091 59922001424 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 59922001425 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 59922001426 dimer interface [polypeptide binding]; other site 59922001427 phosphorylation site [posttranslational modification] 59922001428 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 59922001429 ATP binding site [chemical binding]; other site 59922001430 Mg2+ binding site [ion binding]; other site 59922001431 G-X-G motif; other site 59922001432 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 59922001433 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 59922001434 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 59922001435 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 59922001436 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 59922001437 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 59922001438 ATP binding site [chemical binding]; other site 59922001439 active site 59922001440 substrate binding site [chemical binding]; other site 59922001441 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 59922001442 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 59922001443 Surface antigen; Region: Bac_surface_Ag; pfam01103 59922001444 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 59922001445 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 59922001446 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 59922001447 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 59922001448 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 59922001449 active site 59922001450 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 59922001451 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 59922001452 Peptide methionine sulfoxide reductase; Region: PMSR; pfam01625 59922001453 multifunctional aminopeptidase A; Provisional; Region: PRK00913 59922001454 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 59922001455 interface (dimer of trimers) [polypeptide binding]; other site 59922001456 Substrate-binding/catalytic site; other site 59922001457 Zn-binding sites [ion binding]; other site 59922001458 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 59922001459 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 59922001460 DNA binding residues [nucleotide binding] 59922001461 dimerization interface [polypeptide binding]; other site 59922001462 Domain of unknown function (DUF1825); Region: DUF1825; pfam08855 59922001463 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 59922001464 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 59922001465 active site 59922001466 HIGH motif; other site 59922001467 dimer interface [polypeptide binding]; other site 59922001468 KMSKS motif; other site 59922001469 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 59922001470 RNA binding surface [nucleotide binding]; other site 59922001471 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 59922001472 active site 59922001473 dimer interface [polypeptide binding]; other site 59922001474 membrane protein; Provisional; Region: PRK14419 59922001475 Protein of unknown function (DUF3086); Region: DUF3086; pfam11285 59922001476 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 59922001477 Permease; Region: Permease; pfam02405 59922001478 MFS/sugar transport protein; Region: MFS_2; pfam13347 59922001479 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 59922001480 Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523 59922001481 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 59922001482 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 59922001483 active site 59922001484 catalytic site [active] 59922001485 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 59922001486 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 59922001487 IHF dimer interface [polypeptide binding]; other site 59922001488 IHF - DNA interface [nucleotide binding]; other site 59922001489 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 59922001490 active site 59922001491 HIGH motif; other site 59922001492 nucleotide binding site [chemical binding]; other site 59922001493 active site 59922001494 KMSKS motif; other site 59922001495 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 59922001496 Uncharacterized conserved protein [Function unknown]; Region: COG0397 59922001497 hypothetical protein; Validated; Region: PRK00029 59922001498 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 59922001499 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 59922001500 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 59922001501 Predicted methyltransferases [General function prediction only]; Region: COG0313 59922001502 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 59922001503 putative SAM binding site [chemical binding]; other site 59922001504 putative homodimer interface [polypeptide binding]; other site 59922001505 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 59922001506 active site 59922001507 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 59922001508 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 59922001509 RNase E interface [polypeptide binding]; other site 59922001510 trimer interface [polypeptide binding]; other site 59922001511 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 59922001512 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 59922001513 RNase E interface [polypeptide binding]; other site 59922001514 trimer interface [polypeptide binding]; other site 59922001515 active site 59922001516 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 59922001517 putative nucleic acid binding region [nucleotide binding]; other site 59922001518 G-X-X-G motif; other site 59922001519 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 59922001520 RNA binding site [nucleotide binding]; other site 59922001521 domain interface; other site 59922001522 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 59922001523 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 59922001524 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 59922001525 active site 59922001526 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 59922001527 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 59922001528 putative substrate binding region [chemical binding]; other site 59922001529 seryl-tRNA synthetase; Provisional; Region: PRK05431 59922001530 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 59922001531 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 59922001532 dimer interface [polypeptide binding]; other site 59922001533 active site 59922001534 motif 1; other site 59922001535 motif 2; other site 59922001536 motif 3; other site 59922001537 Ycf46; Provisional; Region: ycf46; CHL00195 59922001538 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 59922001539 Walker A motif; other site 59922001540 ATP binding site [chemical binding]; other site 59922001541 Walker B motif; other site 59922001542 arginine finger; other site 59922001543 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 59922001544 putative inner membrane protein translocase component YidC; Provisional; Region: PRK02654 59922001545 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 59922001546 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 59922001547 Bacterial PH domain; Region: DUF304; pfam03703 59922001548 Ribonuclease P; Region: Ribonuclease_P; pfam00825 59922001549 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 59922001550 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 59922001551 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 59922001552 homotrimer interaction site [polypeptide binding]; other site 59922001553 active site 59922001554 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 59922001555 tandem repeat interface [polypeptide binding]; other site 59922001556 oligomer interface [polypeptide binding]; other site 59922001557 active site residues [active] 59922001558 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 59922001559 EamA-like transporter family; Region: EamA; pfam00892 59922001560 EamA-like transporter family; Region: EamA; pfam00892 59922001561 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 59922001562 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 59922001563 Protein of unknown function (DUF721); Region: DUF721; pfam05258 59922001564 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 59922001565 succinyldiaminopimelate transaminase; Validated; Region: PRK07366 59922001566 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 59922001567 pyridoxal 5'-phosphate binding site [chemical binding]; other site 59922001568 homodimer interface [polypeptide binding]; other site 59922001569 catalytic residue [active] 59922001570 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 59922001571 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 59922001572 Peptidase family M23; Region: Peptidase_M23; pfam01551 59922001573 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 59922001574 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 59922001575 active site 59922001576 phosphorylation site [posttranslational modification] 59922001577 intermolecular recognition site; other site 59922001578 dimerization interface [polypeptide binding]; other site 59922001579 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 59922001580 DNA binding site [nucleotide binding] 59922001581 Response regulator receiver domain; Region: Response_reg; pfam00072 59922001582 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 59922001583 active site 59922001584 phosphorylation site [posttranslational modification] 59922001585 intermolecular recognition site; other site 59922001586 dimerization interface [polypeptide binding]; other site 59922001587 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 59922001588 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 59922001589 Walker A/P-loop; other site 59922001590 ATP binding site [chemical binding]; other site 59922001591 Q-loop/lid; other site 59922001592 ABC transporter signature motif; other site 59922001593 Walker B; other site 59922001594 D-loop; other site 59922001595 H-loop/switch region; other site 59922001596 NAD(P)H-quinone oxidoreductase subunit 2; Provisional; Region: PRK02504 59922001597 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 59922001598 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 59922001599 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 59922001600 active site 59922001601 interdomain interaction site; other site 59922001602 putative metal-binding site [ion binding]; other site 59922001603 nucleotide binding site [chemical binding]; other site 59922001604 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 59922001605 domain I; other site 59922001606 phosphate binding site [ion binding]; other site 59922001607 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 59922001608 domain II; other site 59922001609 domain III; other site 59922001610 nucleotide binding site [chemical binding]; other site 59922001611 DNA binding groove [nucleotide binding] 59922001612 catalytic site [active] 59922001613 domain IV; other site 59922001614 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 59922001615 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 59922001616 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 59922001617 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 59922001618 active site pocket [active] 59922001619 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 59922001620 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 59922001621 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 59922001622 active site 59922001623 catalytic tetrad [active] 59922001624 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 59922001625 Bifunctional nuclease; Region: DNase-RNase; pfam02577 59922001626 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 59922001627 Lumazine binding domain; Region: Lum_binding; pfam00677 59922001628 Lumazine binding domain; Region: Lum_binding; pfam00677 59922001629 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 59922001630 AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250 59922001631 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 59922001632 Subunit I/III interface [polypeptide binding]; other site 59922001633 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 59922001634 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 59922001635 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 59922001636 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 59922001637 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 59922001638 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 59922001639 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 59922001640 UbiA prenyltransferase family; Region: UbiA; pfam01040 59922001641 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 59922001642 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 59922001643 Walker A/P-loop; other site 59922001644 ATP binding site [chemical binding]; other site 59922001645 Q-loop/lid; other site 59922001646 ABC transporter signature motif; other site 59922001647 Walker B; other site 59922001648 D-loop; other site 59922001649 H-loop/switch region; other site 59922001650 ABC-2 type transporter; Region: ABC2_membrane; cl17235 59922001651 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 59922001652 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 59922001653 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 59922001654 putative active site cavity [active] 59922001655 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 59922001656 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 59922001657 ring oligomerisation interface [polypeptide binding]; other site 59922001658 ATP/Mg binding site [chemical binding]; other site 59922001659 stacking interactions; other site 59922001660 hinge regions; other site 59922001661 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 59922001662 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 59922001663 NAD(P) binding site [chemical binding]; other site 59922001664 active site 59922001665 Ion channel; Region: Ion_trans_2; pfam07885 59922001666 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 59922001667 TrkA-N domain; Region: TrkA_N; pfam02254 59922001668 TrkA-C domain; Region: TrkA_C; pfam02080 59922001669 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 59922001670 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 59922001671 substrate binding site; other site 59922001672 dimer interface; other site 59922001673 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 59922001674 dimer interface [polypeptide binding]; other site 59922001675 catalytic triad [active] 59922001676 prenyltransferase; Reviewed; Region: ubiA; PRK12873 59922001677 UbiA prenyltransferase family; Region: UbiA; pfam01040 59922001678 exopolyphosphatase; Region: exo_poly_only; TIGR03706 59922001679 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 59922001680 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 59922001681 non-specific DNA binding site [nucleotide binding]; other site 59922001682 salt bridge; other site 59922001683 sequence-specific DNA binding site [nucleotide binding]; other site 59922001684 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 59922001685 active site 59922001686 SAM binding site [chemical binding]; other site 59922001687 homodimer interface [polypeptide binding]; other site 59922001688 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 59922001689 apocytochrome f; Reviewed; Region: PRK02693 59922001690 cytochrome f; Region: petA; CHL00037 59922001691 cytochrome b6-f complex iron-sulfur subunit; Provisional; Region: PRK13474 59922001692 Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802 59922001693 Iron-sulfur protein (ISP) component of the b6f complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The cytochrome b6f complex from Mastigocladus laminosus, a thermophilic cyanobacterium; Region: Rieske_cytochrome_b6f; cd03471 59922001694 cytochrome b subunit interaction site [polypeptide binding]; other site 59922001695 [2Fe-2S] cluster binding site [ion binding]; other site 59922001696 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 59922001697 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 59922001698 Domain of unknown function (DUF814); Region: DUF814; pfam05670 59922001699 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 59922001700 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 59922001701 catalytic site [active] 59922001702 G-X2-G-X-G-K; other site 59922001703 photosystem I reaction center subunit IX; Provisional; Region: PRK02733 59922001704 Photosystem I reaction centre subunit III; Region: PSI_PsaF; cl03627 59922001705 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 59922001706 tRNA threonylcarbamoyl adenosine modification protein YgjD; Region: T6A_YgjD; TIGR03723 59922001707 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 59922001708 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 59922001709 Walker A motif; other site 59922001710 ATP binding site [chemical binding]; other site 59922001711 Walker B motif; other site 59922001712 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 59922001713 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 59922001714 active site 59922001715 homodimer interface [polypeptide binding]; other site 59922001716 Protein of unknown function (DUF1643); Region: DUF1643; pfam07799 59922001717 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 59922001718 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 59922001719 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 59922001720 HIGH motif; other site 59922001721 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 59922001722 active site 59922001723 KMSKS motif; other site 59922001724 Src Homology 3 domain superfamily; Region: SH3; cl17036 59922001725 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 59922001726 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 59922001727 active site 59922001728 short chain dehydrogenase; Provisional; Region: PRK12367 59922001729 BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857 59922001730 DRTGG domain; Region: DRTGG; pfam07085 59922001731 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 59922001732 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 59922001733 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 59922001734 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 59922001735 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 59922001736 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 59922001737 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 59922001738 Amidase; Region: Amidase; cl11426 59922001739 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 59922001740 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 59922001741 inhibitor-cofactor binding pocket; inhibition site 59922001742 pyridoxal 5'-phosphate binding site [chemical binding]; other site 59922001743 catalytic residue [active] 59922001744 FAD binding domain; Region: FAD_binding_4; pfam01565 59922001745 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 59922001746 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 59922001747 putative catalytic site [active] 59922001748 putative phosphate binding site [ion binding]; other site 59922001749 active site 59922001750 metal binding site A [ion binding]; metal-binding site 59922001751 DNA binding site [nucleotide binding] 59922001752 putative AP binding site [nucleotide binding]; other site 59922001753 putative metal binding site B [ion binding]; other site 59922001754 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 59922001755 hypothetical protein; Provisional; Region: PRK04194 59922001756 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 59922001757 Putative 2OG-Fe(II) oxygenase; Region: 2OG-FeII_Oxy_5; pfam13759 59922001758 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 59922001759 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 59922001760 dimer interface [polypeptide binding]; other site 59922001761 conserved gate region; other site 59922001762 putative PBP binding loops; other site 59922001763 ABC-ATPase subunit interface; other site 59922001764 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 59922001765 dimer interface [polypeptide binding]; other site 59922001766 conserved gate region; other site 59922001767 putative PBP binding loops; other site 59922001768 ABC-ATPase subunit interface; other site 59922001769 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 59922001770 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 59922001771 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 59922001772 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914 59922001773 aromatic arch; other site 59922001774 DCoH dimer interaction site [polypeptide binding]; other site 59922001775 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 59922001776 DCoH tetramer interaction site [polypeptide binding]; other site 59922001777 substrate binding site [chemical binding]; other site 59922001778 hypothetical protein; Region: PHA01748 59922001779 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 59922001780 Protein of unknown function, DUF393; Region: DUF393; pfam04134 59922001781 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 59922001782 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 59922001783 active site 59922001784 Zn binding site [ion binding]; other site 59922001785 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 59922001786 dimer interface [polypeptide binding]; other site 59922001787 substrate binding site [chemical binding]; other site 59922001788 metal binding sites [ion binding]; metal-binding site 59922001789 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 59922001790 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 59922001791 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 59922001792 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 59922001793 domain interfaces; other site 59922001794 active site 59922001795 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 59922001796 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 59922001797 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 59922001798 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 59922001799 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 59922001800 DNA binding residues [nucleotide binding] 59922001801 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 59922001802 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 59922001803 ATP binding site [chemical binding]; other site 59922001804 putative Mg++ binding site [ion binding]; other site 59922001805 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 59922001806 ATP-binding site [chemical binding]; other site 59922001807 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 59922001808 feedback inhibition sensing region; other site 59922001809 homohexameric interface [polypeptide binding]; other site 59922001810 nucleotide binding site [chemical binding]; other site 59922001811 N-acetyl-L-glutamate binding site [chemical binding]; other site 59922001812 Protein of unknown function (DUF2854); Region: DUF2854; pfam11016 59922001813 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 59922001814 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 59922001815 dimer interface [polypeptide binding]; other site 59922001816 ssDNA binding site [nucleotide binding]; other site 59922001817 tetramer (dimer of dimers) interface [polypeptide binding]; other site 59922001818 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 59922001819 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 59922001820 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 59922001821 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 59922001822 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 59922001823 substrate binding site [chemical binding]; other site 59922001824 ATP binding site [chemical binding]; other site 59922001825 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 59922001826 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 59922001827 GDP-binding site [chemical binding]; other site 59922001828 ACT binding site; other site 59922001829 IMP binding site; other site 59922001830 photosystem II protein Psb27; Region: PS_II_psb27; TIGR03044 59922001831 prolyl-tRNA synthetase; Provisional; Region: PRK09194 59922001832 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 59922001833 dimer interface [polypeptide binding]; other site 59922001834 motif 1; other site 59922001835 active site 59922001836 motif 2; other site 59922001837 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 59922001838 putative deacylase active site [active] 59922001839 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 59922001840 active site 59922001841 motif 3; other site 59922001842 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 59922001843 anticodon binding site; other site 59922001844 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 59922001845 dimer interface [polypeptide binding]; other site 59922001846 substrate binding site [chemical binding]; other site 59922001847 metal binding sites [ion binding]; metal-binding site 59922001848 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 59922001849 ArsC family; Region: ArsC; pfam03960 59922001850 putative ArsC-like catalytic residues; other site 59922001851 putative TRX-like catalytic residues [active] 59922001852 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 59922001853 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 59922001854 Catalytic site [active] 59922001855 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 59922001856 dihydroorotase; Provisional; Region: PRK07369 59922001857 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 59922001858 active site 59922001859 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 59922001860 catalytic core [active] 59922001861 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 59922001862 catalytic core [active] 59922001863 CAAX protease self-immunity; Region: Abi; pfam02517 59922001864 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 59922001865 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 59922001866 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 59922001867 transaldolase/EF-hand domain-containing protein; Provisional; Region: PRK12309 59922001868 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 59922001869 active site 59922001870 dimer interface [polypeptide binding]; other site 59922001871 catalytic residue [active] 59922001872 C factor cell-cell signaling protein; Provisional; Region: PRK09009 59922001873 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 59922001874 NADP binding site [chemical binding]; other site 59922001875 homodimer interface [polypeptide binding]; other site 59922001876 active site 59922001877 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 59922001878 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 59922001879 ribosome recycling factor; Reviewed; Region: frr; PRK00083 59922001880 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 59922001881 hinge region; other site 59922001882 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 59922001883 putative nucleotide binding site [chemical binding]; other site 59922001884 uridine monophosphate binding site [chemical binding]; other site 59922001885 homohexameric interface [polypeptide binding]; other site 59922001886 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 59922001887 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 59922001888 homodimer interface [polypeptide binding]; other site 59922001889 Walker A motif; other site 59922001890 ATP binding site [chemical binding]; other site 59922001891 hydroxycobalamin binding site [chemical binding]; other site 59922001892 Walker B motif; other site 59922001893 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 59922001894 S-adenosylmethionine binding site [chemical binding]; other site 59922001895 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 59922001896 active site 59922001897 catalytic residues [active] 59922001898 DNA binding site [nucleotide binding] 59922001899 Int/Topo IB signature motif; other site 59922001900 ferrochelatase; Reviewed; Region: hemH; PRK00035 59922001901 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 59922001902 C-terminal domain interface [polypeptide binding]; other site 59922001903 active site 59922001904 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 59922001905 active site 59922001906 N-terminal domain interface [polypeptide binding]; other site 59922001907 acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK07418 59922001908 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 59922001909 PYR/PP interface [polypeptide binding]; other site 59922001910 dimer interface [polypeptide binding]; other site 59922001911 TPP binding site [chemical binding]; other site 59922001912 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 59922001913 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 59922001914 TPP-binding site [chemical binding]; other site 59922001915 dimer interface [polypeptide binding]; other site 59922001916 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 59922001917 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 59922001918 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 59922001919 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 59922001920 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 59922001921 Protein of unknown function (DUF1092); Region: DUF1092; pfam06485 59922001922 Ribosomal protein S1 [Translation, ribosomal structure and biogenesis]; Region: RpsA; COG0539 59922001923 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 59922001924 RNA binding site [nucleotide binding]; other site 59922001925 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 59922001926 RNA binding site [nucleotide binding]; other site 59922001927 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 59922001928 RNA binding site [nucleotide binding]; other site 59922001929 Creatinine amidohydrolase; Region: Creatininase; pfam02633 59922001930 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 59922001931 dinuclear metal binding motif [ion binding]; other site 59922001932 acyl-ACP reductase; Provisional; Region: PRK14982 59922001933 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 59922001934 NAD(P) binding pocket [chemical binding]; other site 59922001935 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 59922001936 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 59922001937 short chain dehydrogenase; Provisional; Region: PRK07454 59922001938 classical (c) SDRs; Region: SDR_c; cd05233 59922001939 NAD(P) binding site [chemical binding]; other site 59922001940 active site 59922001941 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 59922001942 GTP cyclohydrolase I; Provisional; Region: PLN03044 59922001943 active site 59922001944 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 59922001945 active site 59922001946 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 59922001947 active site 59922001948 putative substrate binding region [chemical binding]; other site 59922001949 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 59922001950 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 59922001951 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 59922001952 Photosystem I protein M (PsaM); Region: PsaM; cl15374 59922001953 protochlorophyllide oxidoreductase; Validated; Region: PRK07453 59922001954 light-dependent protochlorophyllide reductase; Region: LPOR; TIGR01289 59922001955 NAD(P) binding site [chemical binding]; other site 59922001956 active site 59922001957 protochlorophyllide reductase iron-sulfur ATP-binding protein; Provisional; Region: chlL; PRK13185 59922001958 This family of proteins contains bchL and chlL. Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. Three genes, bchL, bchN and bchB, are...; Region: Bchl_like; cd02032 59922001959 P-loop; other site 59922001960 light-independent protochlorophyllide reductase subunit B; Provisional; Region: PRK02910 59922001961 Pchlide_reductase_B: B protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_B; cd01981 59922001962 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 59922001963 Pchlide_reductase_N: N protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_N; cd01979 59922001964 light-independent protochlorophyllide reductase, N subunit; Region: DPOR_bchN; TIGR01279 59922001965 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 59922001966 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 59922001967 Sulfate transporter family; Region: Sulfate_transp; pfam00916 59922001968 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 59922001969 Domain of unknown function (DUF897); Region: DUF897; pfam05982 59922001970 Nitrogen regulatory protein P-II; Region: P-II; cl00412 59922001971 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 1; Region: BMC_like_1_repeat1; cd07051 59922001972 putative hexamer interface [polypeptide binding]; other site 59922001973 putative hexagonal pore; other site 59922001974 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 2; Region: BMC_like_1_repeat2; cd07052 59922001975 putative hexamer interface [polypeptide binding]; other site 59922001976 putative hexagonal pore; other site 59922001977 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 59922001978 active site 59922001979 dimerization interface [polypeptide binding]; other site 59922001980 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 59922001981 Carboxysome Shell 1 (CsoS1); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CsoS1; cd07058 59922001982 Hexamer interface [polypeptide binding]; other site 59922001983 Hexagonal pore residue; other site 59922001984 Hexagonal pore; other site 59922001985 ribulose bisophosphate carboxylase; Reviewed; Region: rbcL; PRK04208 59922001986 Ribulose bisphosphate carboxylase large chain; Region: RuBisCO_large; cl08232 59922001987 dimer interface [polypeptide binding]; other site 59922001988 catalytic residue [active] 59922001989 metal binding site [ion binding]; metal-binding site 59922001990 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527 59922001991 multimerization interface [polypeptide binding]; other site 59922001992 Carboxysome shell peptide mid-region; Region: CsoS2_M; pfam12288 59922001993 Carboxysome shell peptide mid-region; Region: CsoS2_M; pfam12288 59922001994 Carboxysome Shell Carbonic Anhydrase; Region: CsoSCA; pfam08936 59922001995 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 59922001996 Hexamer/Pentamer interface [polypeptide binding]; other site 59922001997 central pore; other site 59922001998 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 59922001999 Hexamer/Pentamer interface [polypeptide binding]; other site 59922002000 central pore; other site 59922002001 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 59922002002 Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982 59922002003 Hexamer interface [polypeptide binding]; other site 59922002004 Hexagonal pore residue; other site 59922002005 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cl00942 59922002006 aromatic arch; other site 59922002007 DCoH dimer interaction site [polypeptide binding]; other site 59922002008 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 59922002009 DCoH tetramer interaction site [polypeptide binding]; other site 59922002010 substrate binding site [chemical binding]; other site 59922002011 probable Rubsico expression protein CbbX; Region: cbbX_cfxQ; TIGR02880 59922002012 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 59922002013 Walker A motif; other site 59922002014 ATP binding site [chemical binding]; other site 59922002015 Walker B motif; other site 59922002016 arginine finger; other site 59922002017 Protein of unknown function (DUF3136); Region: DUF3136; pfam11334 59922002018 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 59922002019 homotrimer interaction site [polypeptide binding]; other site 59922002020 putative active site [active] 59922002021 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 59922002022 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 59922002023 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 59922002024 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 59922002025 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 59922002026 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 59922002027 Walker A/P-loop; other site 59922002028 ATP binding site [chemical binding]; other site 59922002029 Q-loop/lid; other site 59922002030 ABC transporter signature motif; other site 59922002031 Walker B; other site 59922002032 D-loop; other site 59922002033 H-loop/switch region; other site 59922002034 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 59922002035 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 59922002036 Coenzyme A binding pocket [chemical binding]; other site 59922002037 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 59922002038 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 59922002039 Probable Catalytic site; other site 59922002040 transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282 59922002041 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 59922002042 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 59922002043 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 59922002044 protein binding site [polypeptide binding]; other site 59922002045 DnaA N-terminal domain; Region: DnaA_N; pfam11638 59922002046 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 59922002047 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 59922002048 Walker A motif; other site 59922002049 ATP binding site [chemical binding]; other site 59922002050 Walker B motif; other site 59922002051 arginine finger; other site 59922002052 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 59922002053 DnaA box-binding interface [nucleotide binding]; other site 59922002054 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 59922002055 catalytic triad [active] 59922002056 dimer interface [polypeptide binding]; other site 59922002057 Leucine carboxyl methyltransferase; Region: LCM; cl01306 59922002058 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 59922002059 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 59922002060 catalytic loop [active] 59922002061 iron binding site [ion binding]; other site 59922002062 cobyric acid synthase; Provisional; Region: PRK00784 59922002063 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 59922002064 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 59922002065 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 59922002066 catalytic triad [active] 59922002067 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 59922002068 active site 59922002069 dimer interface [polypeptide binding]; other site 59922002070 Mechanosensitive ion channel; Region: MS_channel; pfam00924 59922002071 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 59922002072 Photosystem II protein; Region: PSII; cl08223 59922002073 photosystem II 44 kDa subunit reaction center protein (also called P6 protein, CP43), bacterial and chloroplast; Region: psbC; TIGR01153 59922002074 D1, D2 subunits of photosystem II (PSII); M, L subunits of bacterial photosynthetic reaction center; Region: Photo_RC; cl08220 59922002075 pheophytin binding site; other site 59922002076 chlorophyll binding site; other site 59922002077 quinone binding site; other site 59922002078 Fe binding site [ion binding]; other site 59922002079 photosystem I assembly protein Ycf4; Provisional; Region: PRK02542 59922002080 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 59922002081 active site 59922002082 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 59922002083 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 59922002084 putative valine binding site [chemical binding]; other site 59922002085 dimer interface [polypeptide binding]; other site 59922002086 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 59922002087 hydrolase, alpha/beta fold family protein; Region: PLN02824 59922002088 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 59922002089 N2,N2-dimethylguanosine tRNA methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TRM1; COG1867 59922002090 cytochrome b6-f complex subunit PetM; Reviewed; Region: petM; PRK11876 59922002091 Ycf39; Provisional; Region: ycf39; CHL00194 59922002092 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 59922002093 NAD(P) binding site [chemical binding]; other site 59922002094 putative active site [active] 59922002095 Methyltransferase domain; Region: Methyltransf_31; pfam13847 59922002096 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 59922002097 S-adenosylmethionine binding site [chemical binding]; other site 59922002098 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 59922002099 pseudouridine synthase; Region: TIGR00093 59922002100 active site 59922002101 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 59922002102 rRNA binding site [nucleotide binding]; other site 59922002103 predicted 30S ribosome binding site; other site 59922002104 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 59922002105 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 59922002106 nucleotide binding region [chemical binding]; other site 59922002107 helicase superfamily c-terminal domain; Region: HELICc; smart00490 59922002108 ATP-binding site [chemical binding]; other site 59922002109 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 59922002110 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 59922002111 ligand binding site [chemical binding]; other site 59922002112 homodimer interface [polypeptide binding]; other site 59922002113 NAD(P) binding site [chemical binding]; other site 59922002114 trimer interface B [polypeptide binding]; other site 59922002115 trimer interface A [polypeptide binding]; other site 59922002116 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 59922002117 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 59922002118 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 59922002119 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 59922002120 dimer interface [polypeptide binding]; other site 59922002121 [2Fe-2S] cluster binding site [ion binding]; other site 59922002122 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 59922002123 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 59922002124 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 59922002125 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 59922002126 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 59922002127 putative substrate binding site 1 [chemical binding]; other site 59922002128 Na binding site 1 [ion binding]; other site 59922002129 putative substrate binding site 2 [chemical binding]; other site 59922002130 Na2 binding site [ion binding]; other site 59922002131 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 59922002132 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 59922002133 active site 59922002134 HIGH motif; other site 59922002135 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 59922002136 KMSKS motif; other site 59922002137 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 59922002138 Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093 59922002139 DNA polymerase I; Provisional; Region: PRK05755 59922002140 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 59922002141 active site 59922002142 metal binding site 1 [ion binding]; metal-binding site 59922002143 putative 5' ssDNA interaction site; other site 59922002144 metal binding site 3; metal-binding site 59922002145 metal binding site 2 [ion binding]; metal-binding site 59922002146 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 59922002147 putative DNA binding site [nucleotide binding]; other site 59922002148 putative metal binding site [ion binding]; other site 59922002149 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 59922002150 active site 59922002151 catalytic site [active] 59922002152 substrate binding site [chemical binding]; other site 59922002153 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 59922002154 active site 59922002155 DNA binding site [nucleotide binding] 59922002156 catalytic site [active] 59922002157 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 59922002158 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 59922002159 HlyD family secretion protein; Region: HlyD_3; pfam13437 59922002160 GTP-binding protein YchF; Reviewed; Region: PRK09601 59922002161 YchF GTPase; Region: YchF; cd01900 59922002162 G1 box; other site 59922002163 GTP/Mg2+ binding site [chemical binding]; other site 59922002164 Switch I region; other site 59922002165 G2 box; other site 59922002166 Switch II region; other site 59922002167 G3 box; other site 59922002168 G4 box; other site 59922002169 G5 box; other site 59922002170 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 59922002171 putative high light inducible protein; Region: PHA02337 59922002172 putative high light inducible protein; Region: PHA02337 59922002173 putative high light inducible protein; Region: PHA02337 59922002174 S-layer homology domain; Region: SLH; pfam00395 59922002175 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 59922002176 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 59922002177 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 59922002178 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 59922002179 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 59922002180 dimer interface [polypeptide binding]; other site 59922002181 conserved gate region; other site 59922002182 putative PBP binding loops; other site 59922002183 ABC-ATPase subunit interface; other site 59922002184 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_20; cd08519 59922002185 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 59922002186 homoserine dehydrogenase; Provisional; Region: PRK06349 59922002187 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 59922002188 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 59922002189 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 59922002190 Fe-S metabolism associated domain; Region: SufE; cl00951 59922002191 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 59922002192 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 59922002193 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 59922002194 S-adenosylmethionine binding site [chemical binding]; other site 59922002195 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 59922002196 active site 59922002197 putative DNA-binding cleft [nucleotide binding]; other site 59922002198 dimer interface [polypeptide binding]; other site 59922002199 Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081 59922002200 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 59922002201 Walker A motif; other site 59922002202 ATP binding site [chemical binding]; other site 59922002203 Protein of unknown function (DUF3370); Region: DUF3370; pfam11850 59922002204 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 59922002205 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 59922002206 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 59922002207 Mnd1 family; Region: Mnd1; pfam03962 59922002208 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 59922002209 active site 59922002210 catalytic residues [active] 59922002211 DNA binding site [nucleotide binding] 59922002212 Int/Topo IB signature motif; other site 59922002213 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 59922002214 Cytochrome c; Region: Cytochrom_C; pfam00034 59922002215 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 59922002216 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 59922002217 S-adenosylmethionine binding site [chemical binding]; other site 59922002218 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 59922002219 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 59922002220 putative active site [active] 59922002221 oxyanion strand; other site 59922002222 catalytic triad [active] 59922002223 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 59922002224 catalytic residues [active] 59922002225 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 59922002226 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 59922002227 active site 59922002228 Domain of unknown function (DUF4308); Region: DUF4308; pfam14159 59922002229 DNA gyrase subunit A; Validated; Region: PRK05560 59922002230 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 59922002231 CAP-like domain; other site 59922002232 active site 59922002233 primary dimer interface [polypeptide binding]; other site 59922002234 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 59922002235 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 59922002236 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 59922002237 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 59922002238 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 59922002239 lycopene cyclase family protein; Region: carotene-cycl; TIGR01790 59922002240 lycopene cyclase; Region: lycopene_cycl; TIGR01789 59922002241 Uncharacterized conserved protein [Function unknown]; Region: COG1543 59922002242 N-terminal catalytic domain of alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792 59922002243 active site 59922002244 substrate binding site [chemical binding]; other site 59922002245 catalytic site [active] 59922002246 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 59922002247 2-isopropylmalate synthase; Validated; Region: PRK00915 59922002248 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 59922002249 active site 59922002250 catalytic residues [active] 59922002251 metal binding site [ion binding]; metal-binding site 59922002252 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 59922002253 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 59922002254 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 59922002255 dimer interface [polypeptide binding]; other site 59922002256 conserved gate region; other site 59922002257 putative PBP binding loops; other site 59922002258 ABC-ATPase subunit interface; other site 59922002259 Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862 59922002260 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 59922002261 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 59922002262 active site 59922002263 7TM-HD extracellular; Region: 7TMR-HDED; pfam07697 59922002264 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 59922002265 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 59922002266 Zn2+ binding site [ion binding]; other site 59922002267 Mg2+ binding site [ion binding]; other site 59922002268 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14186 59922002269 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 59922002270 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 59922002271 homodimer interface [polypeptide binding]; other site 59922002272 NADP binding site [chemical binding]; other site 59922002273 substrate binding site [chemical binding]; other site 59922002274 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 59922002275 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 59922002276 substrate binding pocket [chemical binding]; other site 59922002277 chain length determination region; other site 59922002278 substrate-Mg2+ binding site; other site 59922002279 catalytic residues [active] 59922002280 aspartate-rich region 1; other site 59922002281 active site lid residues [active] 59922002282 aspartate-rich region 2; other site 59922002283 Divergent PAP2 family; Region: DUF212; pfam02681 59922002284 AAA domain; Region: AAA_30; pfam13604 59922002285 Family description; Region: UvrD_C_2; pfam13538 59922002286 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 59922002287 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 59922002288 catalytic core [active] 59922002289 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 59922002290 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 59922002291 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 59922002292 catalytic triad [active] 59922002293 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 59922002294 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 59922002295 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 59922002296 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 59922002297 ferredoxin--NADP+ reductase; Provisional; Region: PLN03116 59922002298 These ferredoxin reductases are related to the NADPH cytochrome p450 reductases (CYPOR), but lack the FAD-binding region connecting sub-domain. Ferredoxin-NADP+ reductase (FNR) is an FAD-containing enzyme that catalyzes the reversible electron transfer...; Region: CYPOR_like_FNR; cd06208 59922002299 dimerization interface [polypeptide binding]; other site 59922002300 FAD binding pocket [chemical binding]; other site 59922002301 FAD binding motif [chemical binding]; other site 59922002302 catalytic residues [active] 59922002303 NAD binding pocket [chemical binding]; other site 59922002304 phosphate binding motif [ion binding]; other site 59922002305 beta-alpha-beta structure motif; other site 59922002306 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_11; cd08866 59922002307 putative hydrophobic ligand binding site [chemical binding]; other site 59922002308 adaptive-response sensory kinase; Validated; Region: PRK09303 59922002309 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 59922002310 tetramer interface [polypeptide binding]; other site 59922002311 dimer interface [polypeptide binding]; other site 59922002312 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 59922002313 dimer interface [polypeptide binding]; other site 59922002314 phosphorylation site [posttranslational modification] 59922002315 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 59922002316 ATP binding site [chemical binding]; other site 59922002317 Mg2+ binding site [ion binding]; other site 59922002318 G-X-G motif; other site 59922002319 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 59922002320 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 59922002321 active site 59922002322 phosphorylation site [posttranslational modification] 59922002323 dimerization interface [polypeptide binding]; other site 59922002324 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 59922002325 DNA binding site [nucleotide binding] 59922002326 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 59922002327 putative GSH binding site [chemical binding]; other site 59922002328 catalytic residues [active] 59922002329 BolA-like protein; Region: BolA; pfam01722 59922002330 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 59922002331 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 59922002332 putative acyl-acceptor binding pocket; other site 59922002333 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 59922002334 active site 59922002335 hydrophilic channel; other site 59922002336 dimerization interface [polypeptide binding]; other site 59922002337 catalytic residues [active] 59922002338 active site lid [active] 59922002339 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 59922002340 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 59922002341 active site 59922002342 metal binding site [ion binding]; metal-binding site 59922002343 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 59922002344 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 59922002345 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 59922002346 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 59922002347 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 59922002348 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 59922002349 Part of AAA domain; Region: AAA_19; pfam13245 59922002350 Family description; Region: UvrD_C_2; pfam13538 59922002351 AAA domain; Region: AAA_30; pfam13604 59922002352 AAA domain; Region: AAA_22; pfam13401 59922002353 Family description; Region: UvrD_C_2; pfam13538 59922002354 Cupin domain; Region: Cupin_2; cl17218 59922002355 helicase 45; Provisional; Region: PTZ00424 59922002356 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 59922002357 ATP binding site [chemical binding]; other site 59922002358 Mg++ binding site [ion binding]; other site 59922002359 motif III; other site 59922002360 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 59922002361 nucleotide binding region [chemical binding]; other site 59922002362 ATP-binding site [chemical binding]; other site 59922002363 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 59922002364 putative RNA binding site [nucleotide binding]; other site 59922002365 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 59922002366 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 59922002367 Transcriptional regulator [Transcription]; Region: LytR; COG1316 59922002368 PsbP; Region: PsbP; pfam01789 59922002369 recombination protein RecR; Reviewed; Region: recR; PRK00076 59922002370 RecR protein; Region: RecR; pfam02132 59922002371 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 59922002372 putative active site [active] 59922002373 putative metal-binding site [ion binding]; other site 59922002374 tetramer interface [polypeptide binding]; other site 59922002375 lipoyl synthase; Provisional; Region: PRK12928 59922002376 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02812 59922002377 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 59922002378 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 59922002379 active site 59922002380 Transcriptional regulator [Transcription]; Region: LytR; COG1316 59922002381 4-alpha-glucanotransferase; Provisional; Region: PRK14508 59922002382 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 59922002383 non-specific DNA binding site [nucleotide binding]; other site 59922002384 salt bridge; other site 59922002385 sequence-specific DNA binding site [nucleotide binding]; other site 59922002386 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 59922002387 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 59922002388 RNA binding surface [nucleotide binding]; other site 59922002389 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 59922002390 active site 59922002391 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 59922002392 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 59922002393 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 59922002394 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 59922002395 Sigma-70, region 4; Region: Sigma70_r4; pfam04545 59922002396 DNA binding residues [nucleotide binding] 59922002397 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 59922002398 ABC1 family; Region: ABC1; cl17513 59922002399 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 59922002400 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 59922002401 catalytic residue [active] 59922002402 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 59922002403 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 59922002404 phosphatidate cytidylyltransferase; Region: PLN02953 59922002405 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 59922002406 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 59922002407 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 59922002408 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 59922002409 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 59922002410 putative active site [active] 59922002411 metal binding site [ion binding]; metal-binding site 59922002412 Clp protease ATP binding subunit; Region: clpC; CHL00095 59922002413 Clp amino terminal domain; Region: Clp_N; pfam02861 59922002414 Clp amino terminal domain; Region: Clp_N; pfam02861 59922002415 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 59922002416 Walker A motif; other site 59922002417 ATP binding site [chemical binding]; other site 59922002418 Walker B motif; other site 59922002419 arginine finger; other site 59922002420 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 59922002421 Walker A motif; other site 59922002422 ATP binding site [chemical binding]; other site 59922002423 Walker B motif; other site 59922002424 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 59922002425 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 59922002426 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 59922002427 Coenzyme A binding pocket [chemical binding]; other site 59922002428 diaminopimelate decarboxylase; Region: lysA; TIGR01048 59922002429 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 59922002430 active site 59922002431 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 59922002432 substrate binding site [chemical binding]; other site 59922002433 catalytic residues [active] 59922002434 dimer interface [polypeptide binding]; other site 59922002435 Uncharacterized conserved protein [Function unknown]; Region: COG1624 59922002436 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 59922002437 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 59922002438 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 59922002439 catalytic residue [active] 59922002440 putative FPP diphosphate binding site; other site 59922002441 putative FPP binding hydrophobic cleft; other site 59922002442 dimer interface [polypeptide binding]; other site 59922002443 putative IPP diphosphate binding site; other site 59922002444 biotin synthase; Region: bioB; TIGR00433 59922002445 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 59922002446 FeS/SAM binding site; other site 59922002447 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 59922002448 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 59922002449 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 59922002450 active site residue [active] 59922002451 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 59922002452 aminopeptidase N; Provisional; Region: pepN; PRK14015 59922002453 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 59922002454 active site 59922002455 Zn binding site [ion binding]; other site 59922002456 carotene isomerase; Region: carot_isom; TIGR02730 59922002457 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 59922002458 hydroxyglutarate oxidase; Provisional; Region: PRK11728 59922002459 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 59922002460 Glucose inhibited division protein A; Region: GIDA; pfam01134 59922002461 Photosystem II protein Y (PsbY); Region: PsbY; cl05675 59922002462 chlorophyll a/b binding light-harvesting protein; Region: PS_antenn_a_b; TIGR03041 59922002463 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 59922002464 metabolite-proton symporter; Region: 2A0106; TIGR00883 59922002465 putative substrate translocation pore; other site 59922002466 OsmC-like protein; Region: OsmC; pfam02566 59922002467 Protein of unknown function (DUF3288); Region: DUF3288; pfam11691 59922002468 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473 59922002469 catalytic triad [active] 59922002470 putative active site [active] 59922002471 Protein of unknown function (DUF1499); Region: DUF1499; pfam07386 59922002472 Domain of unknown function (DUF427); Region: DUF427; pfam04248 59922002473 Dienelactone hydrolase family; Region: DLH; pfam01738 59922002474 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 59922002475 aspartate aminotransferase; Provisional; Region: PRK05957 59922002476 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 59922002477 pyridoxal 5'-phosphate binding site [chemical binding]; other site 59922002478 homodimer interface [polypeptide binding]; other site 59922002479 catalytic residue [active] 59922002480 Protein of unknown function (DUF861); Region: Cupin_3; pfam05899 59922002481 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_23; cd04682 59922002482 nudix motif; other site 59922002483 MAPEG family; Region: MAPEG; pfam01124 59922002484 Ion channel; Region: Ion_trans_2; pfam07885 59922002485 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 59922002486 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 59922002487 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 59922002488 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 59922002489 Domain of Unknown Function (DUF1543); Region: DUF1543; pfam07566 59922002490 Domain of Unknown Function (DUF1543); Region: DUF1543; pfam07566 59922002491 Phytochelatin synthase; Region: Phytochelatin; pfam05023 59922002492 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 59922002493 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 59922002494 catalytic triad [active] 59922002495 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 59922002496 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 59922002497 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 59922002498 Coenzyme A binding pocket [chemical binding]; other site 59922002499 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 59922002500 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 59922002501 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 59922002502 acyl-activating enzyme (AAE) consensus motif; other site 59922002503 AMP binding site [chemical binding]; other site 59922002504 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 59922002505 Condensation domain; Region: Condensation; pfam00668 59922002506 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 59922002507 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 59922002508 acyl-activating enzyme (AAE) consensus motif; other site 59922002509 AMP binding site [chemical binding]; other site 59922002510 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 59922002511 thioester reductase domain; Region: Thioester-redct; TIGR01746 59922002512 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 59922002513 putative NAD(P) binding site [chemical binding]; other site 59922002514 active site 59922002515 putative substrate binding site [chemical binding]; other site 59922002516 Protein of unknown function (DUF1651); Region: DUF1651; pfam07864 59922002517 Cupin domain; Region: Cupin_2; pfam07883 59922002518 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 59922002519 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 59922002520 putative DNA binding site [nucleotide binding]; other site 59922002521 dimerization interface [polypeptide binding]; other site 59922002522 putative Zn2+ binding site [ion binding]; other site 59922002523 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK08955 59922002524 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 59922002525 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 59922002526 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 59922002527 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 59922002528 ligand binding site [chemical binding]; other site 59922002529 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 59922002530 putative switch regulator; other site 59922002531 non-specific DNA interactions [nucleotide binding]; other site 59922002532 DNA binding site [nucleotide binding] 59922002533 sequence specific DNA binding site [nucleotide binding]; other site 59922002534 putative cAMP binding site [chemical binding]; other site 59922002535 PBP superfamily domain; Region: PBP_like_2; cl17296 59922002536 S-layer homology domain; Region: SLH; pfam00395 59922002537 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 59922002538 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 59922002539 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 59922002540 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 59922002541 dimer interface [polypeptide binding]; other site 59922002542 phosphorylation site [posttranslational modification] 59922002543 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 59922002544 ATP binding site [chemical binding]; other site 59922002545 Mg2+ binding site [ion binding]; other site 59922002546 G-X-G motif; other site 59922002547 PBP superfamily domain; Region: PBP_like_2; cl17296 59922002548 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 59922002549 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 59922002550 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 59922002551 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 59922002552 Walker A/P-loop; other site 59922002553 ATP binding site [chemical binding]; other site 59922002554 Q-loop/lid; other site 59922002555 ABC transporter signature motif; other site 59922002556 Walker B; other site 59922002557 D-loop; other site 59922002558 H-loop/switch region; other site 59922002559 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 59922002560 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 59922002561 metal binding site [ion binding]; metal-binding site 59922002562 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 59922002563 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 59922002564 P-loop, Walker A motif; other site 59922002565 Base recognition motif; other site 59922002566 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 59922002567 FOG: WD40 repeat [General function prediction only]; Region: COG2319 59922002568 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 59922002569 structural tetrad; other site 59922002570 putative high light inducible protein; Region: PHA02337 59922002571 2TM domain; Region: 2TM; pfam13239 59922002572 putative high light inducible protein; Region: PHA02337 59922002573 Chromate transporter; Region: Chromate_transp; pfam02417 59922002574 Chromate transporter; Region: Chromate_transp; pfam02417 59922002575 Predicted HD phosphohydrolase [General function prediction only]; Region: COG4341; cl17564 59922002576 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 59922002577 Thermostable Phosphite Dehydrogenase; Region: PTDH; cd12157 59922002578 glyoxylate reductase; Reviewed; Region: PRK13243 59922002579 homodimer interface [polypeptide binding]; other site 59922002580 ligand binding site [chemical binding]; other site 59922002581 NAD binding site [chemical binding]; other site 59922002582 catalytic site [active] 59922002583 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 59922002584 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 59922002585 dimer interface [polypeptide binding]; other site 59922002586 conserved gate region; other site 59922002587 ABC-ATPase subunit interface; other site 59922002588 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 59922002589 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 59922002590 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 59922002591 Walker A/P-loop; other site 59922002592 ATP binding site [chemical binding]; other site 59922002593 Q-loop/lid; other site 59922002594 ABC transporter signature motif; other site 59922002595 Walker B; other site 59922002596 D-loop; other site 59922002597 H-loop/switch region; other site 59922002598 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 59922002599 Sodium Bile acid symporter family; Region: SBF; cl17470 59922002600 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 59922002601 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 59922002602 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 59922002603 metal binding site [ion binding]; metal-binding site 59922002604 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 59922002605 AAA domain; Region: AAA_14; pfam13173 59922002606 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 59922002607 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996 59922002608 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 59922002609 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473 59922002610 catalytic triad [active] 59922002611 putative active site [active] 59922002612 Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862 59922002613 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 59922002614 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 59922002615 nif11-like leader peptide domain; Region: ocin_TIGR03798 59922002616 Uncharacterized conserved protein [Function unknown]; Region: COG3349 59922002617 VanW like protein; Region: VanW; pfam04294 59922002618 Putative ParB-like nuclease; Region: ParBc_2; cl17538 59922002619 Protein of unknown function (DUF3303); Region: DUF3303; pfam11746 59922002620 Protein of unknown function (DUF1330); Region: DUF1330; pfam07045 59922002621 Protein of unknown function (DUF1651); Region: DUF1651; pfam07864 59922002622 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 59922002623 Nitrogen fixation protein of unknown function; Region: Nif11; cl06756 59922002624 nif11-like leader peptide domain; Region: ocin_TIGR03798 59922002625 nif11-like leader peptide domain; Region: ocin_TIGR03798 59922002626 Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862 59922002627 Protein of unknown function (DUF3303); Region: DUF3303; pfam11746 59922002628 Domain of unknown function (DUF4114); Region: DUF4114; pfam13448 59922002629 Uncharacterized conserved protein [Function unknown]; Region: COG4095 59922002630 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 59922002631 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 59922002632 Walker A/P-loop; other site 59922002633 ATP binding site [chemical binding]; other site 59922002634 Q-loop/lid; other site 59922002635 ABC transporter signature motif; other site 59922002636 Walker B; other site 59922002637 D-loop; other site 59922002638 H-loop/switch region; other site 59922002639 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 59922002640 dimer interface [polypeptide binding]; other site 59922002641 conserved gate region; other site 59922002642 putative PBP binding loops; other site 59922002643 ABC-ATPase subunit interface; other site 59922002644 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 59922002645 dimer interface [polypeptide binding]; other site 59922002646 conserved gate region; other site 59922002647 putative PBP binding loops; other site 59922002648 ABC-ATPase subunit interface; other site 59922002649 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 59922002650 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 59922002651 substrate binding pocket [chemical binding]; other site 59922002652 membrane-bound complex binding site; other site 59922002653 hinge residues; other site 59922002654 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 59922002655 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 59922002656 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 59922002657 Sulfate transporter family; Region: Sulfate_transp; pfam00916 59922002658 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 59922002659 FAD binding domain; Region: FAD_binding_4; pfam01565 59922002660 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 59922002661 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 59922002662 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 59922002663 putative active site [active] 59922002664 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 59922002665 putative active site [active] 59922002666 Protein of unknown function (DUF2811); Region: DUF2811; pfam10929 59922002667 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 59922002668 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 59922002669 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 59922002670 SPFH domain / Band 7 family; Region: Band_7; pfam01145 59922002671 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 59922002672 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 59922002673 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 59922002674 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 59922002675 substrate binding pocket [chemical binding]; other site 59922002676 membrane-bound complex binding site; other site 59922002677 hinge residues; other site 59922002678 Guanosine kinase-like sugar kinases. Found in bacteria and archaea, the guanosine kinase-like group is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: Guanosine_kinase_like; cd01947 59922002679 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 59922002680 substrate binding site [chemical binding]; other site 59922002681 ATP binding site [chemical binding]; other site 59922002682 Tryptophan-rich protein (DUF2389); Region: DUF2389; pfam09493 59922002683 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 59922002684 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 59922002685 ligand binding site [chemical binding]; other site 59922002686 Uncharacterized conserved protein [Function unknown]; Region: COG4095 59922002687 EamA-like transporter family; Region: EamA; pfam00892 59922002688 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 59922002689 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 59922002690 catalytic residues [active] 59922002691 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 59922002692 catalytic residues [active] 59922002693 Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862 59922002694 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 59922002695 active site 59922002696 catalytic residues [active] 59922002697 DNA binding site [nucleotide binding] 59922002698 Int/Topo IB signature motif; other site 59922002699 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 59922002700 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 59922002701 DNA binding residues [nucleotide binding] 59922002702 dimerization interface [polypeptide binding]; other site 59922002703 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 59922002704 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 59922002705 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 59922002706 DNA binding site [nucleotide binding] 59922002707 active site 59922002708 Int/Topo IB signature motif; other site 59922002709 catalytic residues [active] 59922002710 Protein of unknown function (DUF3764); Region: DUF3764; pfam12594 59922002711 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922002712 TPR motif; other site 59922002713 TPR repeat; Region: TPR_11; pfam13414 59922002714 binding surface 59922002715 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922002716 binding surface 59922002717 TPR motif; other site 59922002718 TPR repeat; Region: TPR_11; pfam13414 59922002719 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922002720 binding surface 59922002721 TPR motif; other site 59922002722 Protein of unknown function (DUF3764); Region: DUF3764; pfam12594 59922002723 TPR repeat; Region: TPR_11; pfam13414 59922002724 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922002725 binding surface 59922002726 TPR motif; other site 59922002727 TPR repeat; Region: TPR_11; pfam13414 59922002728 TPR repeat; Region: TPR_11; pfam13414 59922002729 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922002730 binding surface 59922002731 TPR motif; other site 59922002732 TPR repeat; Region: TPR_11; pfam13414 59922002733 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922002734 binding surface 59922002735 TPR motif; other site 59922002736 Protein of unknown function (DUF3303); Region: DUF3303; pfam11746 59922002737 Pleckstrin homology-like domain; Region: PH-like; cl17171 59922002738 Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862 59922002739 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 59922002740 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 59922002741 AAA domain; Region: AAA_33; pfam13671 59922002742 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 59922002743 active site 59922002744 CBD_II domain; Region: CBD_II; smart00637 59922002745 CBD_II domain; Region: CBD_II; smart00637 59922002746 Glyco_18 domain; Region: Glyco_18; smart00636 59922002747 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 59922002748 active site 59922002749 Surface antigen; Region: Surface_Ag_2; pfam01617 59922002750 Homoserine O-succinyltransferase; Region: HTS; pfam04204 59922002751 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 59922002752 proposed active site lysine [active] 59922002753 conserved cys residue [active] 59922002754 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 59922002755 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 59922002756 homodimer interface [polypeptide binding]; other site 59922002757 substrate-cofactor binding pocket; other site 59922002758 pyridoxal 5'-phosphate binding site [chemical binding]; other site 59922002759 catalytic residue [active] 59922002760 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 59922002761 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 59922002762 N-acetyl-D-glucosamine binding site [chemical binding]; other site 59922002763 catalytic residue [active] 59922002764 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 59922002765 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 59922002766 light-dependent protochlorophyllide reductase; Region: LPOR; TIGR01289 59922002767 NAD(P) binding site [chemical binding]; other site 59922002768 active site 59922002769 Domon-like domain of UDP-N-acetylenolpyruvoylglucosamine reductase; Region: DOMON_murB_like; cd09627 59922002770 putative heme binding site [chemical binding]; other site 59922002771 Phosphotransferase enzyme family; Region: APH; pfam01636 59922002772 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 59922002773 substrate binding site [chemical binding]; other site 59922002774 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 59922002775 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 59922002776 active site 59922002777 metal binding site [ion binding]; metal-binding site 59922002778 DNA binding site [nucleotide binding] 59922002779 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 59922002780 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 59922002781 Walker A/P-loop; other site 59922002782 ATP binding site [chemical binding]; other site 59922002783 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 59922002784 ABC transporter signature motif; other site 59922002785 Walker B; other site 59922002786 D-loop; other site 59922002787 H-loop/switch region; other site 59922002788 glucosylglycerol 3-phosphatase; Region: salt_tol_Pase; TIGR02399 59922002789 Glucosylglycerol-phosphate phosphatase (Salt_tol_Pase); Region: Salt_tol_Pase; pfam09506 59922002790 radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167 59922002791 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 59922002792 FeS/SAM binding site; other site 59922002793 Protein of unknown function (DUF3641); Region: DUF3641; pfam12345 59922002794 Protein of unknown function (DUF552); Region: DUF552; pfam04472 59922002795 Protein of unknown function; Region: DUF3721; pfam12518 59922002796 Protein of unknown function; Region: DUF3721; pfam12518 59922002797 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 59922002798 metal binding site 2 [ion binding]; metal-binding site 59922002799 putative DNA binding helix; other site 59922002800 metal binding site 1 [ion binding]; metal-binding site 59922002801 dimer interface [polypeptide binding]; other site 59922002802 structural Zn2+ binding site [ion binding]; other site 59922002803 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 59922002804 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 59922002805 Isochorismatase family; Region: Isochorismatase; pfam00857 59922002806 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 59922002807 catalytic triad [active] 59922002808 dimer interface [polypeptide binding]; other site 59922002809 conserved cis-peptide bond; other site 59922002810 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 59922002811 Mechanosensitive ion channel; Region: MS_channel; pfam00924 59922002812 Domain of unknown function (DUF389); Region: DUF389; pfam04087 59922002813 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026 59922002814 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 59922002815 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 59922002816 active site 59922002817 metal binding site [ion binding]; metal-binding site 59922002818 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 59922002819 Protein of unknown function (DUF1662); Region: DUF1662; pfam07878 59922002820 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 59922002821 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 59922002822 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 59922002823 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 59922002824 Putative ParB-like nuclease; Region: ParBc_2; cl17538 59922002825 Pyrimidine dimer DNA glycosylase; Region: Pyr_excise; pfam03013 59922002826 Protein of unknown function (DUF1651); Region: DUF1651; pfam07864 59922002827 Transposase IS200 like; Region: Y1_Tnp; cl00848 59922002828 nif11-like leader peptide domain; Region: ocin_TIGR03798 59922002829 Protein of unknown function (DUF1651); Region: DUF1651; pfam07864 59922002830 L-asparaginase II; Region: Asparaginase_II; pfam06089 59922002831 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 59922002832 Protein of unknown function (DUF3318); Region: DUF3318; pfam11780 59922002833 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 59922002834 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 59922002835 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 59922002836 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 59922002837 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 59922002838 ATP-grasp domain; Region: ATP-grasp_4; cl17255 59922002839 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 59922002840 IMP binding site; other site 59922002841 dimer interface [polypeptide binding]; other site 59922002842 interdomain contacts; other site 59922002843 partial ornithine binding site; other site 59922002844 Protein of unknown function (DUF3386); Region: DUF3386; pfam11866 59922002845 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 59922002846 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 59922002847 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 59922002848 Walker A/P-loop; other site 59922002849 ATP binding site [chemical binding]; other site 59922002850 Q-loop/lid; other site 59922002851 ABC transporter signature motif; other site 59922002852 Walker B; other site 59922002853 D-loop; other site 59922002854 H-loop/switch region; other site 59922002855 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 59922002856 RNA binding surface [nucleotide binding]; other site 59922002857 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 59922002858 triosephosphate isomerase; Provisional; Region: PRK14565 59922002859 substrate binding site [chemical binding]; other site 59922002860 dimer interface [polypeptide binding]; other site 59922002861 catalytic triad [active] 59922002862 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 59922002863 dimer interface [polypeptide binding]; other site 59922002864 inhibitor binding site; inhibition site 59922002865 magnesium chelatase subunit H; Provisional; Region: PRK12493 59922002866 Domain of unknown function (DUF3479); Region: DUF3479; pfam11965 59922002867 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 59922002868 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 59922002869 dihydrodipicolinate reductase; Provisional; Region: PRK00048 59922002870 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 59922002871 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 59922002872 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 59922002873 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 59922002874 Protein of unknown function (DUF2949); Region: DUF2949; pfam11165 59922002875 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 59922002876 active site 59922002877 Protein of unknown function (DUF3038); Region: DUF3038; pfam11237 59922002878 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 59922002879 osmolarity response regulator; Provisional; Region: ompR; PRK09468 59922002880 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 59922002881 active site 59922002882 phosphorylation site [posttranslational modification] 59922002883 intermolecular recognition site; other site 59922002884 dimerization interface [polypeptide binding]; other site 59922002885 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 59922002886 DNA binding site [nucleotide binding] 59922002887 HAMP domain; Region: HAMP; pfam00672 59922002888 dimerization interface [polypeptide binding]; other site 59922002889 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 59922002890 ATP binding site [chemical binding]; other site 59922002891 Mg2+ binding site [ion binding]; other site 59922002892 G-X-G motif; other site 59922002893 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 59922002894 S-layer homology domain; Region: SLH; pfam00395 59922002895 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 59922002896 flavodoxin FldA; Validated; Region: PRK09267 59922002897 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 59922002898 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 59922002899 catalytic triad [active] 59922002900 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 59922002901 putative di-iron ligands [ion binding]; other site 59922002902 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 59922002903 GLTT repeat (6 copies); Region: GLTT; pfam01744 59922002904 Protein of unknown function (DUF1662); Region: DUF1662; pfam07878 59922002905 ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent; Region: RTPR; TIGR02505 59922002906 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 59922002907 Methyltransferase domain; Region: Methyltransf_23; pfam13489 59922002908 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 59922002909 S-adenosylmethionine binding site [chemical binding]; other site 59922002910 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 59922002911 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 59922002912 G1 box; other site 59922002913 putative GEF interaction site [polypeptide binding]; other site 59922002914 GTP/Mg2+ binding site [chemical binding]; other site 59922002915 Switch I region; other site 59922002916 G2 box; other site 59922002917 G3 box; other site 59922002918 Switch II region; other site 59922002919 G4 box; other site 59922002920 G5 box; other site 59922002921 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 59922002922 Protein of unknown function (DUF3353); Region: DUF3353; pfam11833 59922002923 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 59922002924 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 59922002925 Walker A/P-loop; other site 59922002926 ATP binding site [chemical binding]; other site 59922002927 Q-loop/lid; other site 59922002928 ABC transporter signature motif; other site 59922002929 Walker B; other site 59922002930 D-loop; other site 59922002931 H-loop/switch region; other site 59922002932 Protein of unknown function (DUF3531); Region: DUF3531; pfam12049 59922002933 RNA methyltransferase, RsmE family; Region: TIGR00046 59922002934 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 59922002935 Integral membrane protein DUF92; Region: DUF92; pfam01940 59922002936 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 59922002937 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 59922002938 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_3; cd01835 59922002939 active site 59922002940 catalytic triad [active] 59922002941 oxyanion hole [active] 59922002942 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 59922002943 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 59922002944 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 59922002945 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 59922002946 Walker A/P-loop; other site 59922002947 ATP binding site [chemical binding]; other site 59922002948 Q-loop/lid; other site 59922002949 ABC transporter signature motif; other site 59922002950 Walker B; other site 59922002951 D-loop; other site 59922002952 H-loop/switch region; other site 59922002953 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 59922002954 aspartate aminotransferase; Provisional; Region: PRK05764 59922002955 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 59922002956 pyridoxal 5'-phosphate binding site [chemical binding]; other site 59922002957 homodimer interface [polypeptide binding]; other site 59922002958 catalytic residue [active] 59922002959 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 59922002960 active site 59922002961 Fe-S cluster binding site [ion binding]; other site 59922002962 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 59922002963 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 59922002964 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 59922002965 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 59922002966 C-terminal peptidase (prc); Region: prc; TIGR00225 59922002967 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 59922002968 protein binding site [polypeptide binding]; other site 59922002969 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 59922002970 Catalytic dyad [active] 59922002971 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 59922002972 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 59922002973 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 59922002974 ATP binding site [chemical binding]; other site 59922002975 putative Mg++ binding site [ion binding]; other site 59922002976 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 59922002977 nucleotide binding region [chemical binding]; other site 59922002978 ATP-binding site [chemical binding]; other site 59922002979 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 59922002980 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 59922002981 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 59922002982 [2Fe-2S] cluster binding site [ion binding]; other site 59922002983 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 59922002984 hydrophobic ligand binding site; other site 59922002985 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 59922002986 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 59922002987 putative active site [active] 59922002988 substrate binding site [chemical binding]; other site 59922002989 putative cosubstrate binding site; other site 59922002990 catalytic site [active] 59922002991 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 59922002992 substrate binding site [chemical binding]; other site 59922002993 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 59922002994 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 59922002995 Protein of unknown function (DUF2996); Region: DUF2996; pfam11210 59922002996 aromatic acid decarboxylase; Validated; Region: PRK05920 59922002997 Flavoprotein; Region: Flavoprotein; pfam02441 59922002998 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 59922002999 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 59922003000 RNB domain; Region: RNB; pfam00773 59922003001 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 59922003002 RNA binding site [nucleotide binding]; other site 59922003003 Predicted membrane protein [Function unknown]; Region: COG2119 59922003004 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 59922003005 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 59922003006 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 59922003007 ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034 59922003008 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 59922003009 putative ion selectivity filter; other site 59922003010 putative pore gating glutamate residue; other site 59922003011 putative H+/Cl- coupling transport residue; other site 59922003012 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 59922003013 DHH family; Region: DHH; pfam01368 59922003014 DHHA1 domain; Region: DHHA1; pfam02272 59922003015 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 59922003016 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 59922003017 motif II; other site 59922003018 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 59922003019 active site 59922003020 ribosomal protein L32; Validated; Region: rpl32; CHL00152 59922003021 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 59922003022 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 59922003023 Walker A motif; other site 59922003024 ATP binding site [chemical binding]; other site 59922003025 Walker B motif; other site 59922003026 arginine finger; other site 59922003027 Peptidase family M41; Region: Peptidase_M41; pfam01434 59922003028 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 59922003029 Uncharacterized conserved protein [Function unknown]; Region: COG1615 59922003030 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 59922003031 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 59922003032 dimer interface [polypeptide binding]; other site 59922003033 decamer (pentamer of dimers) interface [polypeptide binding]; other site 59922003034 catalytic triad [active] 59922003035 peroxidatic and resolving cysteines [active] 59922003036 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 59922003037 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 59922003038 Peptidase family M23; Region: Peptidase_M23; pfam01551 59922003039 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 59922003040 Peptidase family M23; Region: Peptidase_M23; pfam01551 59922003041 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 59922003042 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 59922003043 homotrimer interface [polypeptide binding]; other site 59922003044 Walker A motif; other site 59922003045 GTP binding site [chemical binding]; other site 59922003046 Walker B motif; other site 59922003047 proton extrusion protein PcxA; Provisional; Region: PRK02507 59922003048 Repair protein; Region: Repair_PSII; pfam04536 59922003049 tellurite resistance protein terB; Region: terB; cd07176 59922003050 putative metal binding site [ion binding]; other site 59922003051 Protein of unknown function (DUF2930); Region: DUF2930; pfam11152 59922003052 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 59922003053 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 59922003054 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 59922003055 active site 59922003056 HIGH motif; other site 59922003057 KMSKS motif; other site 59922003058 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 59922003059 tRNA binding surface [nucleotide binding]; other site 59922003060 anticodon binding site; other site 59922003061 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 59922003062 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 59922003063 RNB domain; Region: RNB; pfam00773 59922003064 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 59922003065 ribosomal protein L33; Region: rpl33; CHL00104 59922003066 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 59922003067 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 59922003068 putative tRNA-binding site [nucleotide binding]; other site 59922003069 B3/4 domain; Region: B3_4; pfam03483 59922003070 tRNA synthetase B5 domain; Region: B5; smart00874 59922003071 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 59922003072 dimer interface [polypeptide binding]; other site 59922003073 motif 1; other site 59922003074 motif 3; other site 59922003075 motif 2; other site 59922003076 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 59922003077 TRAM domain; Region: TRAM; cl01282 59922003078 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 59922003079 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 59922003080 S-adenosylmethionine binding site [chemical binding]; other site 59922003081 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 59922003082 HSP70 interaction site [polypeptide binding]; other site 59922003083 Protein of unknown function (DUF3370); Region: DUF3370; pfam11850 59922003084 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 59922003085 ATP adenylyltransferase (5',5'''-P-1,P-4-tetraphosphate phosphorylase II) [Nucleotide transport and metabolism]; Region: APA2; COG4360 59922003086 ATP adenylyltransferase; Region: ATP_transf; pfam09830 59922003087 Stage II sporulation protein; Region: SpoIID; pfam08486 59922003088 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 59922003089 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 59922003090 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 59922003091 substrate binding pocket [chemical binding]; other site 59922003092 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 59922003093 B12 binding site [chemical binding]; other site 59922003094 cobalt ligand [ion binding]; other site 59922003095 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 59922003096 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 59922003097 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 59922003098 homodimer interface [polypeptide binding]; other site 59922003099 substrate-cofactor binding pocket; other site 59922003100 catalytic residue [active] 59922003101 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 59922003102 CobN/Magnesium Chelatase; Region: CobN-Mg_chel; pfam02514 59922003103 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 59922003104 PHP domain; Region: PHP; pfam02811 59922003105 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 59922003106 active site 59922003107 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 59922003108 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 59922003109 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 59922003110 GIY-YIG motif/motif A; other site 59922003111 active site 59922003112 catalytic site [active] 59922003113 putative DNA binding site [nucleotide binding]; other site 59922003114 metal binding site [ion binding]; metal-binding site 59922003115 UvrB/uvrC motif; Region: UVR; pfam02151 59922003116 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 59922003117 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 59922003118 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 59922003119 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 59922003120 active site 59922003121 (T/H)XGH motif; other site 59922003122 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 59922003123 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 59922003124 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 59922003125 Domain of unknown function (DUF4330); Region: DUF4330; pfam14221 59922003126 Domain of unknown function (DUF1995); Region: DUF1995; pfam09353 59922003127 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 59922003128 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 59922003129 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 59922003130 Sm and related proteins; Region: Sm_like; cl00259 59922003131 heptamer interface [polypeptide binding]; other site 59922003132 Sm1 motif; other site 59922003133 hexamer interface [polypeptide binding]; other site 59922003134 RNA binding site [nucleotide binding]; other site 59922003135 Sm2 motif; other site 59922003136 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 59922003137 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 59922003138 HIGH motif; other site 59922003139 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 59922003140 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 59922003141 active site 59922003142 KMSKS motif; other site 59922003143 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 59922003144 tRNA binding surface [nucleotide binding]; other site 59922003145 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 59922003146 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14096 59922003147 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 59922003148 active site 59922003149 dimer interface [polypeptide binding]; other site 59922003150 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 59922003151 dimer interface [polypeptide binding]; other site 59922003152 active site 59922003153 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 59922003154 amidase catalytic site [active] 59922003155 Zn binding residues [ion binding]; other site 59922003156 substrate binding site [chemical binding]; other site 59922003157 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 59922003158 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 59922003159 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 59922003160 protein binding site [polypeptide binding]; other site 59922003161 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 59922003162 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 59922003163 active site 59922003164 substrate binding site [chemical binding]; other site 59922003165 cosubstrate binding site; other site 59922003166 catalytic site [active] 59922003167 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 59922003168 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 59922003169 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II/unknown domain fusion protein; Provisional; Region: PRK09319 59922003170 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 59922003171 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 59922003172 dimerization interface [polypeptide binding]; other site 59922003173 active site 59922003174 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 59922003175 active site 59922003176 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 59922003177 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 59922003178 putative active site [active] 59922003179 Protein of unknown function (DUF3110); Region: DUF3110; pfam11360 59922003180 DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214 59922003181 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 59922003182 HSP70 interaction site [polypeptide binding]; other site 59922003183 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 59922003184 substrate binding site [polypeptide binding]; other site 59922003185 dimer interface [polypeptide binding]; other site 59922003186 molecular chaperone DnaK; Provisional; Region: PRK13410 59922003187 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 59922003188 nucleotide binding site [chemical binding]; other site 59922003189 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 59922003190 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 59922003191 dimer interface [polypeptide binding]; other site 59922003192 conserved gate region; other site 59922003193 ABC-ATPase subunit interface; other site 59922003194 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 59922003195 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 59922003196 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 59922003197 dimer interface [polypeptide binding]; other site 59922003198 conserved gate region; other site 59922003199 putative PBP binding loops; other site 59922003200 ABC-ATPase subunit interface; other site 59922003201 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14259 59922003202 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 59922003203 Walker A/P-loop; other site 59922003204 ATP binding site [chemical binding]; other site 59922003205 Q-loop/lid; other site 59922003206 ABC transporter signature motif; other site 59922003207 Walker B; other site 59922003208 D-loop; other site 59922003209 H-loop/switch region; other site 59922003210 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 59922003211 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 59922003212 active site 59922003213 dimerization interface [polypeptide binding]; other site 59922003214 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 59922003215 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 59922003216 dimer interface [polypeptide binding]; other site 59922003217 motif 1; other site 59922003218 active site 59922003219 motif 2; other site 59922003220 motif 3; other site 59922003221 Ferredoxin [Energy production and conversion]; Region: COG1146 59922003222 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 59922003223 heat shock protein 90; Provisional; Region: PRK05218 59922003224 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 59922003225 ATP binding site [chemical binding]; other site 59922003226 Mg2+ binding site [ion binding]; other site 59922003227 G-X-G motif; other site 59922003228 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 59922003229 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 59922003230 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 59922003231 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 59922003232 dimer interface [polypeptide binding]; other site 59922003233 conserved gate region; other site 59922003234 putative PBP binding loops; other site 59922003235 ABC-ATPase subunit interface; other site 59922003236 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 59922003237 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 59922003238 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 59922003239 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 59922003240 Walker A/P-loop; other site 59922003241 ATP binding site [chemical binding]; other site 59922003242 Q-loop/lid; other site 59922003243 ABC transporter signature motif; other site 59922003244 Walker B; other site 59922003245 D-loop; other site 59922003246 H-loop/switch region; other site 59922003247 TOBE domain; Region: TOBE_2; pfam08402 59922003248 polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609 59922003249 Protein of unknown function (DUF2499); Region: DUF2499; pfam10693 59922003250 Protein of unknown function (DUF3593); Region: DUF3593; pfam12159 59922003251 photosystem I reaction center subunit PsaK; Region: PS_I_psaK; TIGR03049 59922003252 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 59922003253 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 59922003254 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 59922003255 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 59922003256 TPP-binding site; other site 59922003257 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 59922003258 PYR/PP interface [polypeptide binding]; other site 59922003259 dimer interface [polypeptide binding]; other site 59922003260 TPP binding site [chemical binding]; other site 59922003261 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 59922003262 threonine dehydratase; Reviewed; Region: PRK09224 59922003263 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 59922003264 tetramer interface [polypeptide binding]; other site 59922003265 pyridoxal 5'-phosphate binding site [chemical binding]; other site 59922003266 catalytic residue [active] 59922003267 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 59922003268 putative Ile/Val binding site [chemical binding]; other site 59922003269 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 59922003270 putative Ile/Val binding site [chemical binding]; other site 59922003271 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 59922003272 YGGT family; Region: YGGT; pfam02325 59922003273 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 59922003274 putative metal binding site [ion binding]; other site 59922003275 pyruvate kinase; Provisional; Region: PRK06354 59922003276 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 59922003277 domain interfaces; other site 59922003278 active site 59922003279 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 59922003280 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 59922003281 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 59922003282 FtsX-like permease family; Region: FtsX; pfam02687 59922003283 cell division protein; Validated; Region: ftsH; CHL00176 59922003284 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 59922003285 Walker A motif; other site 59922003286 ATP binding site [chemical binding]; other site 59922003287 Walker B motif; other site 59922003288 arginine finger; other site 59922003289 Peptidase family M41; Region: Peptidase_M41; pfam01434 59922003290 Clp protease; Region: CLP_protease; pfam00574 59922003291 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 59922003292 oligomer interface [polypeptide binding]; other site 59922003293 active site residues [active] 59922003294 Thf1-like protein; Reviewed; Region: PRK13266 59922003295 photosystem II biogenesis protein Psp29; Region: PS_II_psb29; TIGR03060 59922003296 cytochrome b6-f complex subunit PetN; Provisional; Region: petN; PRK02529 59922003297 ATP-dependent Clp protease adaptor; Reviewed; Region: clpS; PRK13019 59922003298 Predicted metal-binding protein (DUF2103); Region: DUF2103; cl01651 59922003299 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 59922003300 ATP-grasp domain; Region: ATP-grasp; pfam02222 59922003301 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 59922003302 dimer interface [polypeptide binding]; other site 59922003303 conserved gate region; other site 59922003304 putative PBP binding loops; other site 59922003305 ABC-ATPase subunit interface; other site 59922003306 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 59922003307 active site 59922003308 dimer interface [polypeptide binding]; other site 59922003309 metal binding site [ion binding]; metal-binding site 59922003310 Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636 59922003311 Repair protein; Region: Repair_PSII; pfam04536 59922003312 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 59922003313 catalytic residue [active] 59922003314 TIGR04168 family protein; Region: TIGR04168 59922003315 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 59922003316 quinolinate synthetase; Provisional; Region: PRK09375 59922003317 Putative serine esterase (DUF676); Region: DUF676; pfam05057 59922003318 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 59922003319 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 59922003320 Walker A/P-loop; other site 59922003321 ATP binding site [chemical binding]; other site 59922003322 Q-loop/lid; other site 59922003323 ABC transporter signature motif; other site 59922003324 Walker B; other site 59922003325 D-loop; other site 59922003326 H-loop/switch region; other site 59922003327 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 59922003328 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 59922003329 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 59922003330 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 59922003331 Walker A/P-loop; other site 59922003332 ATP binding site [chemical binding]; other site 59922003333 Q-loop/lid; other site 59922003334 ABC transporter signature motif; other site 59922003335 Walker B; other site 59922003336 D-loop; other site 59922003337 H-loop/switch region; other site 59922003338 NHLM bacteriocin system ABC transporter, ATP-binding protein; Region: NHLM_micro_ABC2; TIGR03797 59922003339 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 59922003340 NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein; Region: NHLM_micro_ABC1; TIGR03796 59922003341 putative active site [active] 59922003342 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 59922003343 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 59922003344 Walker A/P-loop; other site 59922003345 ATP binding site [chemical binding]; other site 59922003346 Q-loop/lid; other site 59922003347 ABC transporter signature motif; other site 59922003348 Walker B; other site 59922003349 D-loop; other site 59922003350 H-loop/switch region; other site 59922003351 NHLM bacteriocin system secretion protein; Region: NHLM_micro_HlyD; TIGR03794 59922003352 Outer membrane efflux protein; Region: OEP; pfam02321 59922003353 Outer membrane efflux protein; Region: OEP; pfam02321 59922003354 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972 59922003355 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 59922003356 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 59922003357 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 59922003358 Walker A/P-loop; other site 59922003359 ATP binding site [chemical binding]; other site 59922003360 Q-loop/lid; other site 59922003361 ABC transporter signature motif; other site 59922003362 Walker B; other site 59922003363 D-loop; other site 59922003364 H-loop/switch region; other site 59922003365 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 59922003366 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 59922003367 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 59922003368 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 59922003369 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 59922003370 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 59922003371 catalytic site [active] 59922003372 subunit interface [polypeptide binding]; other site 59922003373 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 59922003374 anti sigma factor interaction site; other site 59922003375 regulatory phosphorylation site [posttranslational modification]; other site 59922003376 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cl00258 59922003377 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 59922003378 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 59922003379 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 59922003380 Domain of unknown function (DUF1816); Region: DUF1816; pfam08846 59922003381 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 59922003382 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 59922003383 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK07374 59922003384 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 59922003385 active site 59922003386 PHP Thumb interface [polypeptide binding]; other site 59922003387 metal binding site [ion binding]; metal-binding site 59922003388 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 59922003389 generic binding surface I; other site 59922003390 generic binding surface II; other site 59922003391 Protein of unknown function (DUF3464); Region: DUF3464; pfam11947 59922003392 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 59922003393 16S/18S rRNA binding site [nucleotide binding]; other site 59922003394 S13e-L30e interaction site [polypeptide binding]; other site 59922003395 25S rRNA binding site [nucleotide binding]; other site 59922003396 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 59922003397 RuvA N terminal domain; Region: RuvA_N; pfam01330 59922003398 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 59922003399 EamA-like transporter family; Region: EamA; pfam00892 59922003400 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 59922003401 EamA-like transporter family; Region: EamA; pfam00892 59922003402 Curli production assembly/transport component CsgG; Region: CsgG; pfam03783 59922003403 DNA primase; Validated; Region: dnaG; PRK05667 59922003404 CHC2 zinc finger; Region: zf-CHC2; pfam01807 59922003405 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 59922003406 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 59922003407 active site 59922003408 metal binding site [ion binding]; metal-binding site 59922003409 interdomain interaction site; other site 59922003410 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 59922003411 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 59922003412 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 59922003413 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 59922003414 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 59922003415 active site 59922003416 DNA binding site [nucleotide binding] 59922003417 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 59922003418 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 59922003419 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 59922003420 Catalytic site [active] 59922003421 2TM domain; Region: 2TM; pfam13239 59922003422 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 59922003423 DoxX; Region: DoxX; pfam07681 59922003424 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4337 59922003425 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 59922003426 active site residue [active] 59922003427 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 59922003428 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 59922003429 EamA-like transporter family; Region: EamA; pfam00892 59922003430 hypothetical protein; Provisional; Region: PRK14689 59922003431 glutamate dehydrogenase; Provisional; Region: PRK09414 59922003432 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 59922003433 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 59922003434 NAD(P) binding site [chemical binding]; other site 59922003435 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 59922003436 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 59922003437 S-adenosylmethionine binding site [chemical binding]; other site 59922003438 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK02534 59922003439 Protein of unknown function (DUF3082); Region: DUF3082; pfam11282 59922003440 pyruvate dehydrogenase E1 component beta subunit; Validated; Region: odpB; CHL00144 59922003441 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 59922003442 alpha subunit interface [polypeptide binding]; other site 59922003443 TPP binding site [chemical binding]; other site 59922003444 heterodimer interface [polypeptide binding]; other site 59922003445 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 59922003446 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 59922003447 protein-export membrane protein SecD; Region: secD; TIGR01129 59922003448 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 59922003449 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 59922003450 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 59922003451 Protein export membrane protein; Region: SecD_SecF; cl14618 59922003452 nif11-like leader peptide domain; Region: ocin_TIGR03798 59922003453 Methyltransferase domain; Region: Methyltransf_23; pfam13489 59922003454 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 59922003455 S-adenosylmethionine binding site [chemical binding]; other site 59922003456 Protein of unknown function (DUF3104); Region: DUF3104; pfam11302 59922003457 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 59922003458 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 59922003459 Mg2+ binding site [ion binding]; other site 59922003460 G-X-G motif; other site 59922003461 GUN4-like; Region: GUN4; pfam05419 59922003462 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 59922003463 tRNA 2-selenouridine synthase; Region: tRNA_sel_U_synt; TIGR03167 59922003464 active site residue [active] 59922003465 photosystem II reaction center protein Psb28; Provisional; Region: PRK13612 59922003466 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 59922003467 Domain of unknown function DUF20; Region: UPF0118; pfam01594 59922003468 glutamine synthetase, type I; Region: GlnA; TIGR00653 59922003469 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 59922003470 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 59922003471 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 59922003472 homodimer interface [polypeptide binding]; other site 59922003473 pyridoxal 5'-phosphate binding site [chemical binding]; other site 59922003474 catalytic residue [active] 59922003475 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 59922003476 nucleoside/Zn binding site; other site 59922003477 dimer interface [polypeptide binding]; other site 59922003478 catalytic motif [active] 59922003479 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 59922003480 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 59922003481 catalytic residue [active] 59922003482 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 59922003483 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 59922003484 G1 box; other site 59922003485 GTP/Mg2+ binding site [chemical binding]; other site 59922003486 Switch I region; other site 59922003487 G2 box; other site 59922003488 Switch II region; other site 59922003489 G3 box; other site 59922003490 G4 box; other site 59922003491 G5 box; other site 59922003492 Domain of unknown function (DUF697); Region: DUF697; pfam05128 59922003493 lipoprotein signal peptidase; Provisional; Region: PRK14792 59922003494 BioY family; Region: BioY; pfam02632 59922003495 Protein of unknown function (DUF3148); Region: DUF3148; pfam11347 59922003496 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 59922003497 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 59922003498 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 59922003499 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 59922003500 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 59922003501 phycocyanobilin:ferredoxin oxidoreductase; Validated; Region: PRK02816 59922003502 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 59922003503 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 59922003504 HlyD family secretion protein; Region: HlyD_3; pfam13437 59922003505 DevC protein; Region: devC; TIGR01185 59922003506 FtsX-like permease family; Region: FtsX; pfam02687 59922003507 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 59922003508 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 59922003509 Walker A/P-loop; other site 59922003510 ATP binding site [chemical binding]; other site 59922003511 Q-loop/lid; other site 59922003512 ABC transporter signature motif; other site 59922003513 Walker B; other site 59922003514 D-loop; other site 59922003515 H-loop/switch region; other site 59922003516 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 59922003517 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 59922003518 active site 59922003519 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 59922003520 rRNA interaction site [nucleotide binding]; other site 59922003521 S8 interaction site; other site 59922003522 putative laminin-1 binding site; other site 59922003523 elongation factor Ts; Reviewed; Region: tsf; PRK12332 59922003524 UBA/TS-N domain; Region: UBA; pfam00627 59922003525 Elongation factor TS; Region: EF_TS; pfam00889 59922003526 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 59922003527 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 59922003528 generic binding surface II; other site 59922003529 ssDNA binding site; other site 59922003530 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 59922003531 ATP binding site [chemical binding]; other site 59922003532 putative Mg++ binding site [ion binding]; other site 59922003533 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 59922003534 nucleotide binding region [chemical binding]; other site 59922003535 ATP-binding site [chemical binding]; other site 59922003536 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 59922003537 sulfite reductase subunit beta; Provisional; Region: PRK13504 59922003538 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 59922003539 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 59922003540 Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092 59922003541 geranylgeranyl reductase; Region: ChlP; TIGR02028 59922003542 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 59922003543 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 59922003544 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 59922003545 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 59922003546 G1 box; other site 59922003547 putative GEF interaction site [polypeptide binding]; other site 59922003548 GTP/Mg2+ binding site [chemical binding]; other site 59922003549 Switch I region; other site 59922003550 G2 box; other site 59922003551 G3 box; other site 59922003552 Switch II region; other site 59922003553 G4 box; other site 59922003554 G5 box; other site 59922003555 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 59922003556 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 59922003557 Domain of unknown function (DUF309); Region: DUF309; pfam03745 59922003558 OstA-like protein; Region: OstA; cl00844 59922003559 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 59922003560 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 59922003561 Walker A/P-loop; other site 59922003562 ATP binding site [chemical binding]; other site 59922003563 Q-loop/lid; other site 59922003564 ABC transporter signature motif; other site 59922003565 Walker B; other site 59922003566 D-loop; other site 59922003567 H-loop/switch region; other site 59922003568 Predicted permeases [General function prediction only]; Region: COG0795 59922003569 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 59922003570 cytochrome c biogenesis protein; Region: ccsA; CHL00045 59922003571 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 59922003572 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 59922003573 substrate binding site [chemical binding]; other site 59922003574 hexamer interface [polypeptide binding]; other site 59922003575 metal binding site [ion binding]; metal-binding site 59922003576 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 59922003577 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 59922003578 putative active site [active] 59922003579 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 59922003580 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 59922003581 tRNA; other site 59922003582 putative tRNA binding site [nucleotide binding]; other site 59922003583 putative NADP binding site [chemical binding]; other site 59922003584 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 59922003585 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862 59922003586 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 59922003587 ligand binding site; other site 59922003588 oligomer interface; other site 59922003589 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 59922003590 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 59922003591 dimer interface [polypeptide binding]; other site 59922003592 N-terminal domain interface [polypeptide binding]; other site 59922003593 sulfate 1 binding site; other site 59922003594 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 59922003595 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 59922003596 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 59922003597 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 59922003598 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 59922003599 putative active site [active] 59922003600 Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547 59922003601 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 59922003602 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 59922003603 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 59922003604 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 59922003605 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 59922003606 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 59922003607 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 59922003608 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 59922003609 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 59922003610 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 59922003611 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 59922003612 dimer interface [polypeptide binding]; other site 59922003613 conserved gate region; other site 59922003614 putative PBP binding loops; other site 59922003615 ABC-ATPase subunit interface; other site 59922003616 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 59922003617 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 59922003618 Walker A/P-loop; other site 59922003619 ATP binding site [chemical binding]; other site 59922003620 Q-loop/lid; other site 59922003621 ABC transporter signature motif; other site 59922003622 Walker B; other site 59922003623 D-loop; other site 59922003624 H-loop/switch region; other site 59922003625 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 59922003626 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 59922003627 S-adenosylmethionine binding site [chemical binding]; other site 59922003628 Methyltransferase domain; Region: Methyltransf_23; pfam13489 59922003629 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 59922003630 S-adenosylmethionine binding site [chemical binding]; other site 59922003631 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 59922003632 HetN oxidoreductase-like, classical (c) SDR; Region: HetN_like_SDR_c; cd08932 59922003633 putative NAD(P) binding site [chemical binding]; other site 59922003634 active site 59922003635 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2859 59922003636 Domain of unknown function (DUF4278); Region: DUF4278; pfam14105 59922003637 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 59922003638 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 59922003639 active site 59922003640 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 59922003641 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 59922003642 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 59922003643 dimer interface [polypeptide binding]; other site 59922003644 PYR/PP interface [polypeptide binding]; other site 59922003645 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit [Energy production and conversion]; Region: PorA; COG0674 59922003646 TPP binding site [chemical binding]; other site 59922003647 substrate binding site [chemical binding]; other site 59922003648 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 59922003649 pyruvate/ketoisovalerate ferredoxin oxidoreductase subunit gamma; Provisional; Region: PRK14029 59922003650 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 59922003651 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 59922003652 TPP-binding site [chemical binding]; other site 59922003653 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 59922003654 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 59922003655 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 59922003656 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 59922003657 putative active site [active] 59922003658 catalytic triad [active] 59922003659 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 59922003660 dimer interface [polypeptide binding]; other site 59922003661 catalytic triad [active] 59922003662 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 59922003663 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 59922003664 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 59922003665 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 59922003666 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 59922003667 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 59922003668 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 59922003669 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 59922003670 Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029 59922003671 active site 59922003672 tartrate dehydrogenase; Region: TTC; TIGR02089 59922003673 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 59922003674 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 59922003675 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 59922003676 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 59922003677 trimer interface [polypeptide binding]; other site 59922003678 active site 59922003679 UDP-GlcNAc binding site [chemical binding]; other site 59922003680 lipid binding site [chemical binding]; lipid-binding site 59922003681 gamma-glutamyl kinase; Provisional; Region: PRK05429 59922003682 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 59922003683 nucleotide binding site [chemical binding]; other site 59922003684 homotetrameric interface [polypeptide binding]; other site 59922003685 putative phosphate binding site [ion binding]; other site 59922003686 putative allosteric binding site; other site 59922003687 PUA domain; Region: PUA; pfam01472 59922003688 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 59922003689 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 59922003690 active site 59922003691 motif I; other site 59922003692 motif II; other site 59922003693 Protein of unknown function (DUF1292); Region: DUF1292; cl01608 59922003694 Protein of unknown function (DUF3727); Region: DUF3727; pfam12527 59922003695 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 59922003696 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996 59922003697 Protein of unknown function (DUF3685); Region: DUF3685; pfam12452 59922003698 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 59922003699 metal binding site 2 [ion binding]; metal-binding site 59922003700 putative DNA binding helix; other site 59922003701 metal binding site 1 [ion binding]; metal-binding site 59922003702 dimer interface [polypeptide binding]; other site 59922003703 structural Zn2+ binding site [ion binding]; other site 59922003704 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 59922003705 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 59922003706 catalytic residues [active] 59922003707 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 59922003708 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 59922003709 NAD(P) binding site [chemical binding]; other site 59922003710 active site 59922003711 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 59922003712 FOG: CBS domain [General function prediction only]; Region: COG0517 59922003713 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 59922003714 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 59922003715 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 59922003716 Ion channel; Region: Ion_trans_2; pfam07885 59922003717 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 59922003718 membrane-bound complex binding site; other site 59922003719 hinge residues; other site 59922003720 Protein of unknown function (DUF1662); Region: DUF1662; pfam07878 59922003721 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 59922003722 trimer interface [polypeptide binding]; other site 59922003723 putative Zn binding site [ion binding]; other site 59922003724 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 59922003725 GSH binding site [chemical binding]; other site 59922003726 catalytic residues [active] 59922003727 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 59922003728 Coenzyme A binding pocket [chemical binding]; other site 59922003729 Cytochrome c; Region: Cytochrom_C; cl11414 59922003730 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 59922003731 PBP superfamily domain; Region: PBP_like_2; cl17296 59922003732 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 59922003733 NADH(P)-binding; Region: NAD_binding_10; pfam13460 59922003734 NAD(P) binding site [chemical binding]; other site 59922003735 putative active site [active] 59922003736 Rhomboid family; Region: Rhomboid; cl11446 59922003737 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 59922003738 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 59922003739 minor groove reading motif; other site 59922003740 helix-hairpin-helix signature motif; other site 59922003741 substrate binding pocket [chemical binding]; other site 59922003742 active site 59922003743 Macrophage migration inhibitory factor (MIF); Region: MIF; pfam01187 59922003744 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 59922003745 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 59922003746 putative switch regulator; other site 59922003747 non-specific DNA interactions [nucleotide binding]; other site 59922003748 DNA binding site [nucleotide binding] 59922003749 sequence specific DNA binding site [nucleotide binding]; other site 59922003750 putative cAMP binding site [chemical binding]; other site 59922003751 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 59922003752 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 59922003753 Walker A/P-loop; other site 59922003754 ATP binding site [chemical binding]; other site 59922003755 Q-loop/lid; other site 59922003756 ABC transporter signature motif; other site 59922003757 Walker B; other site 59922003758 D-loop; other site 59922003759 H-loop/switch region; other site 59922003760 TOBE domain; Region: TOBE_2; pfam08402 59922003761 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 59922003762 Ferritin-like domain; Region: Ferritin; pfam00210 59922003763 ferroxidase diiron center [ion binding]; other site 59922003764 helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419 59922003765 non-specific DNA interactions [nucleotide binding]; other site 59922003766 DNA binding site [nucleotide binding] 59922003767 sequence specific DNA binding site [nucleotide binding]; other site 59922003768 putative cAMP binding site [chemical binding]; other site 59922003769 chlorophyll a/b binding light-harvesting protein; Region: PS_antenn_a_b; TIGR03041 59922003770 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 59922003771 Ferritin-like domain; Region: Ferritin; pfam00210 59922003772 ferroxidase diiron center [ion binding]; other site 59922003773 AhpC/TSA antioxidant enzyme; Region: AhpC-TSA_2; pfam13911 59922003774 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 59922003775 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 59922003776 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 59922003777 TPR repeat; Region: TPR_11; pfam13414 59922003778 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922003779 binding surface 59922003780 TPR motif; other site 59922003781 TPR repeat; Region: TPR_11; pfam13414 59922003782 TPR repeat; Region: TPR_11; pfam13414 59922003783 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922003784 binding surface 59922003785 TPR motif; other site 59922003786 TPR repeat; Region: TPR_11; pfam13414 59922003787 TPR repeat; Region: TPR_11; pfam13414 59922003788 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922003789 binding surface 59922003790 TPR motif; other site 59922003791 TPR repeat; Region: TPR_11; pfam13414 59922003792 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922003793 binding surface 59922003794 TPR motif; other site 59922003795 TPR repeat; Region: TPR_11; pfam13414 59922003796 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922003797 TPR repeat; Region: TPR_11; pfam13414 59922003798 binding surface 59922003799 TPR motif; other site 59922003800 short chain dehydrogenase; Provisional; Region: PRK06197 59922003801 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 59922003802 putative NAD(P) binding site [chemical binding]; other site 59922003803 active site 59922003804 Protein of unknown function, DUF393; Region: DUF393; pfam04134 59922003805 Protein of unknown function (DUF3119); Region: DUF3119; pfam11317 59922003806 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 59922003807 Coenzyme A binding pocket [chemical binding]; other site 59922003808 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 59922003809 pyridoxal 5'-phosphate binding site [chemical binding]; other site 59922003810 catalytic residue [active] 59922003811 YrhK-like protein; Region: YrhK; pfam14145 59922003812 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 59922003813 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 59922003814 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 59922003815 C-terminal domain interface [polypeptide binding]; other site 59922003816 GSH binding site (G-site) [chemical binding]; other site 59922003817 dimer interface [polypeptide binding]; other site 59922003818 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 59922003819 substrate binding pocket (H-site) [chemical binding]; other site 59922003820 N-terminal domain interface [polypeptide binding]; other site 59922003821 glutathione reductase; Validated; Region: PRK06116 59922003822 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 59922003823 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 59922003824 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 59922003825 K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367 59922003826 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 59922003827 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 59922003828 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 59922003829 active site 59922003830 substrate binding pocket [chemical binding]; other site 59922003831 dimer interface [polypeptide binding]; other site 59922003832 NADH dehydrogenase transmembrane subunit; Region: NdhL; pfam10716 59922003833 Protein of unknown function (DUF3007); Region: DUF3007; pfam11460 59922003834 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 59922003835 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 59922003836 substrate binding site [chemical binding]; other site 59922003837 active site 59922003838 catalytic residues [active] 59922003839 heterodimer interface [polypeptide binding]; other site 59922003840 AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250 59922003841 YciI-like protein; Reviewed; Region: PRK12864 59922003842 Cytochrome c; Region: Cytochrom_C; cl11414 59922003843 Phosphate-starvation-inducible E; Region: PsiE; pfam06146 59922003844 Uncharacterized conserved protein [Function unknown]; Region: COG3339 59922003845 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 59922003846 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 59922003847 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 59922003848 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 59922003849 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 59922003850 DNA binding residues [nucleotide binding] 59922003851 Predicted membrane protein (DUF2214); Region: DUF2214; pfam09980 59922003852 Zinc-dependent metalloprotease; MMP_like sub-family 1. A group of bacterial, archaeal, and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_1; cd04279 59922003853 active site 59922003854 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 59922003855 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 59922003856 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 59922003857 metal binding site [ion binding]; metal-binding site 59922003858 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 59922003859 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 59922003860 Clp amino terminal domain; Region: Clp_N; pfam02861 59922003861 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 59922003862 Walker A motif; other site 59922003863 ATP binding site [chemical binding]; other site 59922003864 Walker B motif; other site 59922003865 arginine finger; other site 59922003866 Protein-interacting V-domain of mammalian Alix and related domains; Region: V_Alix_like; cl14654 59922003867 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 59922003868 Walker A motif; other site 59922003869 ATP binding site [chemical binding]; other site 59922003870 Walker B motif; other site 59922003871 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 59922003872 Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862 59922003873 plastocyanin; Provisional; Region: PRK02710 59922003874 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 59922003875 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 59922003876 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 59922003877 NAD(P) binding site [chemical binding]; other site 59922003878 active site 59922003879 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 59922003880 substrate binding site [chemical binding]; other site 59922003881 active site 59922003882 glycogen branching enzyme; Provisional; Region: PRK05402 59922003883 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 59922003884 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 59922003885 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 59922003886 active site 59922003887 catalytic site [active] 59922003888 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 59922003889 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 59922003890 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 59922003891 Domain of unknown function (DUF4332); Region: DUF4332; pfam14229 59922003892 Protein of function (DUF2518); Region: DUF2518; pfam10726 59922003893 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 59922003894 Family of unknown function (DUF490); Region: DUF490; pfam04357 59922003895 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 59922003896 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 59922003897 nucleotide binding site [chemical binding]; other site 59922003898 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 59922003899 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 59922003900 putative catalytic cysteine [active] 59922003901 Dihydroneopterin aldolase; Region: FolB; smart00905 59922003902 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 59922003903 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 59922003904 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 59922003905 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 59922003906 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 59922003907 active site 59922003908 Zn binding site [ion binding]; other site 59922003909 NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK12561 59922003910 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 59922003911 homoserine kinase; Provisional; Region: PRK01212 59922003912 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 59922003913 glucokinase, proteobacterial type; Region: glk; TIGR00749 59922003914 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 59922003915 nucleotide binding site [chemical binding]; other site 59922003916 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 59922003917 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 59922003918 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 59922003919 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 59922003920 active site 59922003921 dimer interface [polypeptide binding]; other site 59922003922 motif 1; other site 59922003923 motif 2; other site 59922003924 motif 3; other site 59922003925 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 59922003926 anticodon binding site; other site 59922003927 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 59922003928 catalytic residue [active] 59922003929 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 59922003930 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 59922003931 active site 59922003932 HIGH motif; other site 59922003933 dimer interface [polypeptide binding]; other site 59922003934 KMSKS motif; other site 59922003935 Domain of unknown function (DUF697); Region: DUF697; pfam05128 59922003936 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 59922003937 protein I interface; other site 59922003938 D2 interface; other site 59922003939 protein T interface; other site 59922003940 chlorophyll binding site; other site 59922003941 beta carotene binding site; other site 59922003942 pheophytin binding site; other site 59922003943 manganese-stabilizing polypeptide interface; other site 59922003944 CP43 interface; other site 59922003945 protein L interface; other site 59922003946 oxygen evolving complex binding site; other site 59922003947 bromide binding site; other site 59922003948 quinone binding site; other site 59922003949 Fe binding site [ion binding]; other site 59922003950 core light harvesting interface; other site 59922003951 cytochrome b559 alpha subunit interface; other site 59922003952 cytochrome c-550 interface; other site 59922003953 protein J interface; other site 59922003954 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 59922003955 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 59922003956 metal binding site [ion binding]; metal-binding site 59922003957 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 59922003958 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 59922003959 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 59922003960 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 59922003961 ABC-ATPase subunit interface; other site 59922003962 dimer interface [polypeptide binding]; other site 59922003963 putative PBP binding regions; other site 59922003964 Methyltransferase domain; Region: Methyltransf_23; pfam13489 59922003965 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 59922003966 S-adenosylmethionine binding site [chemical binding]; other site 59922003967 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 59922003968 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 59922003969 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 59922003970 malonyl-CoA binding site [chemical binding]; other site 59922003971 dimer interface [polypeptide binding]; other site 59922003972 active site 59922003973 product binding site; other site 59922003974 Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862 59922003975 Domain of unknown function (DUF4336); Region: DUF4336; pfam14234 59922003976 Protein of unknown function (DUF760); Region: DUF760; pfam05542 59922003977 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 59922003978 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 59922003979 Catalytic site [active] 59922003980 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 59922003981 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 59922003982 dimer interface [polypeptide binding]; other site 59922003983 tetramer interface [polypeptide binding]; other site 59922003984 PYR/PP interface [polypeptide binding]; other site 59922003985 TPP binding site [chemical binding]; other site 59922003986 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 59922003987 TPP-binding site; other site 59922003988 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 59922003989 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 59922003990 substrate binding site [chemical binding]; other site 59922003991 oxyanion hole (OAH) forming residues; other site 59922003992 trimer interface [polypeptide binding]; other site 59922003993 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 59922003994 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 59922003995 glycogen synthase; Provisional; Region: glgA; PRK00654 59922003996 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 59922003997 ADP-binding pocket [chemical binding]; other site 59922003998 homodimer interface [polypeptide binding]; other site 59922003999 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 59922004000 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 59922004001 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 59922004002 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14360 59922004003 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 59922004004 Substrate binding site; other site 59922004005 Mg++ binding site; other site 59922004006 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 59922004007 active site 59922004008 substrate binding site [chemical binding]; other site 59922004009 CoA binding site [chemical binding]; other site 59922004010 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 59922004011 S-adenosylmethionine binding site [chemical binding]; other site 59922004012 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 59922004013 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 59922004014 hinge; other site 59922004015 active site 59922004016 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 59922004017 2-phosphosulfolactate phosphatase; Provisional; Region: PRK00886 59922004018 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 59922004019 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 59922004020 nitrilase; Region: PLN02798 59922004021 putative active site [active] 59922004022 catalytic triad [active] 59922004023 dimer interface [polypeptide binding]; other site 59922004024 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 59922004025 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 59922004026 active site 59922004027 metal binding site [ion binding]; metal-binding site 59922004028 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 59922004029 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 59922004030 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 59922004031 substrate binding pocket [chemical binding]; other site 59922004032 chain length determination region; other site 59922004033 substrate-Mg2+ binding site; other site 59922004034 catalytic residues [active] 59922004035 aspartate-rich region 1; other site 59922004036 active site lid residues [active] 59922004037 aspartate-rich region 2; other site 59922004038 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 59922004039 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 59922004040 motif II; other site 59922004041 acetyl-CoA synthetase; Provisional; Region: PRK00174 59922004042 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 59922004043 active site 59922004044 CoA binding site [chemical binding]; other site 59922004045 acyl-activating enzyme (AAE) consensus motif; other site 59922004046 AMP binding site [chemical binding]; other site 59922004047 acetate binding site [chemical binding]; other site 59922004048 Protein of unknown function (DUF1350); Region: DUF1350; pfam07082 59922004049 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 59922004050 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 59922004051 catalytic triad [active] 59922004052 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 59922004053 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 59922004054 active site 59922004055 catalytic site [active] 59922004056 substrate binding site [chemical binding]; other site 59922004057 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 59922004058 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 59922004059 active site 59922004060 catalytic residues [active] 59922004061 metal binding site [ion binding]; metal-binding site 59922004062 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 59922004063 active site 59922004064 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 59922004065 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 59922004066 Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820 59922004067 Nitrogen fixation protein of unknown function; Region: Nif11; cl06756 59922004068 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922004069 TPR motif; other site 59922004070 binding surface 59922004071 TPR repeat; Region: TPR_11; pfam13414 59922004072 TPR repeat; Region: TPR_11; pfam13414 59922004073 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922004074 binding surface 59922004075 TPR motif; other site 59922004076 Tetratricopeptide repeat; Region: TPR_16; pfam13432 59922004077 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922004078 binding surface 59922004079 TPR motif; other site 59922004080 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922004081 binding surface 59922004082 TPR motif; other site 59922004083 TPR repeat; Region: TPR_11; pfam13414 59922004084 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922004085 binding surface 59922004086 TPR motif; other site 59922004087 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922004088 binding surface 59922004089 TPR motif; other site 59922004090 TPR repeat; Region: TPR_11; pfam13414 59922004091 TPR repeat; Region: TPR_11; pfam13414 59922004092 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922004093 binding surface 59922004094 TPR motif; other site 59922004095 Putative 2OG-Fe(II) oxygenase; Region: 2OG-FeII_Oxy_5; pfam13759 59922004096 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 59922004097 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 59922004098 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 59922004099 Catalytic site [active] 59922004100 ornithine carbamoyltransferase; Provisional; Region: PRK00779 59922004101 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 59922004102 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 59922004103 FtsH Extracellular; Region: FtsH_ext; pfam06480 59922004104 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 59922004105 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 59922004106 Walker A motif; other site 59922004107 ATP binding site [chemical binding]; other site 59922004108 Walker B motif; other site 59922004109 arginine finger; other site 59922004110 Peptidase family M41; Region: Peptidase_M41; pfam01434 59922004111 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 59922004112 Ion channel; Region: Ion_trans_2; pfam07885 59922004113 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 59922004114 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 59922004115 catalytic motif [active] 59922004116 Zn binding site [ion binding]; other site 59922004117 RibD C-terminal domain; Region: RibD_C; cl17279 59922004118 Protein of unknown function (DUF3122); Region: DUF3122; pfam11320 59922004119 Predicted bile acid beta-glucosidase [Carbohydrate transport and metabolism]; Region: COG4354 59922004120 beta-Glucocerebrosidase 2 N terminal; Region: GBA2_N; pfam12215 59922004121 Protein of unknown function, DUF608; Region: DUF608; pfam04685 59922004122 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 59922004123 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 59922004124 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 59922004125 active site 59922004126 putative homodimer interface [polypeptide binding]; other site 59922004127 SAM binding site [chemical binding]; other site 59922004128 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 59922004129 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 59922004130 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 59922004131 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02649 59922004132 ATP-NAD kinase; Region: NAD_kinase; pfam01513 59922004133 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 59922004134 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 59922004135 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 59922004136 dimer interface [polypeptide binding]; other site 59922004137 motif 1; other site 59922004138 active site 59922004139 motif 2; other site 59922004140 motif 3; other site 59922004141 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 59922004142 Protein of unknown function (DUF3611); Region: DUF3611; pfam12263 59922004143 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 59922004144 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 59922004145 active site 59922004146 Riboflavin kinase; Region: Flavokinase; smart00904 59922004147 thiamine-phosphate pyrophosphorylase; Provisional; Region: PRK02615 59922004148 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 59922004149 thiamine phosphate binding site [chemical binding]; other site 59922004150 active site 59922004151 pyrophosphate binding site [ion binding]; other site 59922004152 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 59922004153 thiS-thiF/thiG interaction site; other site 59922004154 Protein of unknown function (DUF1517); Region: DUF1517; cl01807 59922004155 Protein of unknown function (DUF1517); Region: DUF1517; pfam07466 59922004156 AIR carboxylase; Region: AIRC; smart01001 59922004157 uncharacterized cyanobacterial protein, TIGR03792 family; Region: TIGR03792 59922004158 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 59922004159 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 59922004160 homotrimer interaction site [polypeptide binding]; other site 59922004161 zinc binding site [ion binding]; other site 59922004162 CDP-binding sites; other site 59922004163 GTPase Era; Reviewed; Region: era; PRK00089 59922004164 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 59922004165 G1 box; other site 59922004166 GTP/Mg2+ binding site [chemical binding]; other site 59922004167 Switch I region; other site 59922004168 G2 box; other site 59922004169 Switch II region; other site 59922004170 G3 box; other site 59922004171 G4 box; other site 59922004172 G5 box; other site 59922004173 KH domain; Region: KH_2; pfam07650 59922004174 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 59922004175 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 59922004176 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 59922004177 putative substrate translocation pore; other site 59922004178 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 59922004179 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 59922004180 PhoH-like protein; Region: PhoH; pfam02562 59922004181 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 59922004182 signal recognition particle protein; Provisional; Region: PRK10867 59922004183 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 59922004184 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 59922004185 P loop; other site 59922004186 GTP binding site [chemical binding]; other site 59922004187 Signal peptide binding domain; Region: SRP_SPB; pfam02978 59922004188 DnaJ domain; Region: DnaJ; pfam00226 59922004189 Protein of unknown function (DUF4101); Region: DUF4101; pfam13355 59922004190 pyruvate dehydrogenase E1 component alpha subunit; Reviewed; Region: odpA; CHL00149 59922004191 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 59922004192 tetramer interface [polypeptide binding]; other site 59922004193 TPP-binding site [chemical binding]; other site 59922004194 heterodimer interface [polypeptide binding]; other site 59922004195 phosphorylation loop region [posttranslational modification] 59922004196 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 59922004197 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 59922004198 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 59922004199 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 59922004200 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 59922004201 DNA binding residues [nucleotide binding] 59922004202 Uncharacterized conserved protein [Function unknown]; Region: COG0062 59922004203 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 59922004204 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 59922004205 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 59922004206 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 59922004207 putative active site [active] 59922004208 catalytic triad [active] 59922004209 putative dimer interface [polypeptide binding]; other site 59922004210 Methyltransferase domain; Region: Methyltransf_12; pfam08242 59922004211 Stf0 sulphotransferase; Region: Sulphotransf; cl01835 59922004212 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 59922004213 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 59922004214 superoxide dismutase, Ni; Region: sodN; TIGR02753 59922004215 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 59922004216 Catalytic site [active] 59922004217 High-affinity nickel-transport protein; Region: NicO; cl00964 59922004218 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 59922004219 active site 59922004220 ribulose/triose binding site [chemical binding]; other site 59922004221 phosphate binding site [ion binding]; other site 59922004222 substrate (anthranilate) binding pocket [chemical binding]; other site 59922004223 product (indole) binding pocket [chemical binding]; other site 59922004224 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 59922004225 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 59922004226 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 59922004227 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 59922004228 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 59922004229 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 59922004230 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 59922004231 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 59922004232 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 59922004233 hinge; other site 59922004234 active site 59922004235 acetylornithine aminotransferase; Provisional; Region: PRK02627 59922004236 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 59922004237 inhibitor-cofactor binding pocket; inhibition site 59922004238 pyridoxal 5'-phosphate binding site [chemical binding]; other site 59922004239 catalytic residue [active] 59922004240 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 59922004241 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 59922004242 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 59922004243 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 59922004244 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 59922004245 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 59922004246 FAD binding domain; Region: FAD_binding_4; pfam01565 59922004247 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 59922004248 putative deaminase; Validated; Region: PRK06846 59922004249 active site 59922004250 Domain of unknown function (DUF4359); Region: DUF4359; pfam14271 59922004251 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14333 59922004252 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 59922004253 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 59922004254 FeS/SAM binding site; other site 59922004255 TRAM domain; Region: TRAM; cl01282 59922004256 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 59922004257 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 59922004258 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 59922004259 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 59922004260 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 59922004261 cell division protein FtsZ; Validated; Region: PRK09330 59922004262 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 59922004263 nucleotide binding site [chemical binding]; other site 59922004264 SulA interaction site; other site 59922004265 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 59922004266 oligomerization interface [polypeptide binding]; other site 59922004267 active site 59922004268 metal binding site [ion binding]; metal-binding site 59922004269 coproporphyrinogen III oxidase; Provisional; Region: PRK07379 59922004270 HemN C-terminal domain; Region: HemN_C; pfam06969 59922004271 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 59922004272 putative active site [active] 59922004273 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 59922004274 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 59922004275 oligomer interface [polypeptide binding]; other site 59922004276 active site residues [active] 59922004277 Clp protease; Region: CLP_protease; pfam00574 59922004278 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 59922004279 oligomer interface [polypeptide binding]; other site 59922004280 active site residues [active] 59922004281 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 59922004282 ketol-acid reductoisomerase; Provisional; Region: PRK05479 59922004283 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 59922004284 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 59922004285 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 59922004286 Bacterial sugar transferase; Region: Bac_transf; pfam02397 59922004287 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 59922004288 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 59922004289 putative ADP-binding pocket [chemical binding]; other site 59922004290 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 59922004291 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 59922004292 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 59922004293 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 59922004294 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 59922004295 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 59922004296 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 59922004297 Ligand Binding Site [chemical binding]; other site 59922004298 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 59922004299 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 59922004300 putative active site [active] 59922004301 oxyanion strand; other site 59922004302 catalytic triad [active] 59922004303 imidazole glycerol phosphate synthase subunit HisF; Provisional; Region: PRK01033 59922004304 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 59922004305 phosphate binding site [ion binding]; other site 59922004306 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 59922004307 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 59922004308 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 59922004309 Tetratricopeptide repeat; Region: TPR_12; pfam13424 59922004310 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922004311 binding surface 59922004312 TPR motif; other site 59922004313 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922004314 binding surface 59922004315 TPR motif; other site 59922004316 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 59922004317 multiple promoter invertase; Provisional; Region: mpi; PRK13413 59922004318 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 59922004319 catalytic residues [active] 59922004320 catalytic nucleophile [active] 59922004321 Presynaptic Site I dimer interface [polypeptide binding]; other site 59922004322 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 59922004323 Synaptic Flat tetramer interface [polypeptide binding]; other site 59922004324 Synaptic Site I dimer interface [polypeptide binding]; other site 59922004325 DNA binding site [nucleotide binding] 59922004326 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 59922004327 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 59922004328 TPR repeat; Region: TPR_11; pfam13414 59922004329 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922004330 binding surface 59922004331 TPR motif; other site 59922004332 TPR repeat; Region: TPR_11; pfam13414 59922004333 TPR repeat; Region: TPR_11; pfam13414 59922004334 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922004335 binding surface 59922004336 TPR motif; other site 59922004337 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922004338 TPR motif; other site 59922004339 TPR repeat; Region: TPR_11; pfam13414 59922004340 binding surface 59922004341 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 59922004342 Competence protein; Region: Competence; pfam03772 59922004343 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 59922004344 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 59922004345 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 59922004346 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 59922004347 dimer interface [polypeptide binding]; other site 59922004348 motif 1; other site 59922004349 active site 59922004350 motif 2; other site 59922004351 motif 3; other site 59922004352 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 59922004353 TPR repeat; Region: TPR_11; pfam13414 59922004354 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922004355 binding surface 59922004356 TPR motif; other site 59922004357 TPR repeat; Region: TPR_11; pfam13414 59922004358 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922004359 binding surface 59922004360 TPR motif; other site 59922004361 Tetratricopeptide repeat; Region: TPR_12; pfam13424 59922004362 TPR repeat; Region: TPR_11; pfam13414 59922004363 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922004364 binding surface 59922004365 TPR motif; other site 59922004366 Tetratricopeptide repeat; Region: TPR_12; pfam13424 59922004367 Methyltransferase domain; Region: Methyltransf_31; pfam13847 59922004368 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 59922004369 S-adenosylmethionine binding site [chemical binding]; other site 59922004370 L-aspartate oxidase; Provisional; Region: PRK07395 59922004371 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 59922004372 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 59922004373 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 59922004374 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 59922004375 substrate binding site [chemical binding]; other site 59922004376 glutamase interaction surface [polypeptide binding]; other site 59922004377 Protein of unknown function (DUF2862); Region: DUF2862; pfam11061 59922004378 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 59922004379 UbiA prenyltransferase family; Region: UbiA; pfam01040 59922004380 Transglycosylase; Region: Transgly; pfam00912 59922004381 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 59922004382 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 59922004383 16S rRNA methyltransferase B; Provisional; Region: PRK14901 59922004384 NusB family; Region: NusB; pfam01029 59922004385 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 59922004386 S-adenosylmethionine binding site [chemical binding]; other site 59922004387 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 59922004388 DNA binding site [nucleotide binding] 59922004389 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 59922004390 active site 59922004391 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 59922004392 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 59922004393 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 59922004394 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 59922004395 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 59922004396 ABC-ATPase subunit interface; other site 59922004397 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 59922004398 ATP binding site [chemical binding]; other site 59922004399 Mg2+ binding site [ion binding]; other site 59922004400 G-X-G motif; other site 59922004401 hypothetical protein; Provisional; Region: PRK05409 59922004402 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 59922004403 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 59922004404 Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093 59922004405 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; pfam02666 59922004406 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 59922004407 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 59922004408 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 59922004409 HAMP domain; Region: HAMP; pfam00672 59922004410 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 59922004411 dimer interface [polypeptide binding]; other site 59922004412 phosphorylation site [posttranslational modification] 59922004413 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 59922004414 ATP binding site [chemical binding]; other site 59922004415 Mg2+ binding site [ion binding]; other site 59922004416 G-X-G motif; other site 59922004417 Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966 59922004418 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 59922004419 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 59922004420 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 59922004421 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 59922004422 metal ion-dependent adhesion site (MIDAS); other site 59922004423 GTP-binding protein LepA; Provisional; Region: PRK05433 59922004424 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 59922004425 G1 box; other site 59922004426 putative GEF interaction site [polypeptide binding]; other site 59922004427 GTP/Mg2+ binding site [chemical binding]; other site 59922004428 Switch I region; other site 59922004429 G2 box; other site 59922004430 G3 box; other site 59922004431 Switch II region; other site 59922004432 G4 box; other site 59922004433 G5 box; other site 59922004434 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 59922004435 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 59922004436 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 59922004437 malate:quinone oxidoreductase; Validated; Region: PRK05257 59922004438 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 59922004439 NifU-like domain; Region: NifU; pfam01106 59922004440 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 59922004441 active site 59922004442 NifU-like domain; Region: NifU; cl00484 59922004443 Protein of unknown function (DUF3137); Region: DUF3137; pfam11335 59922004444 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 59922004445 type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897 59922004446 LanM-like proteins. LanM is a bifunctional enzyme, involved in the synthesis of class II lantibiotics. It is responsible for both the dehydration and the cyclization of the precursor-peptide during lantibiotic synthesis. The C-terminal domain shows...; Region: LanM-like; cd04792 59922004447 active site 59922004448 zinc binding site [ion binding]; other site 59922004449 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 59922004450 Fatty acid desaturase; Region: FA_desaturase; pfam00487 59922004451 putative di-iron ligands [ion binding]; other site 59922004452 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 59922004453 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 59922004454 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 59922004455 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 59922004456 catalytic residue [active] 59922004457 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 59922004458 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 59922004459 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 59922004460 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 59922004461 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 59922004462 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 59922004463 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 59922004464 Haemolytic domain; Region: Haemolytic; pfam01809 59922004465 ribosomal protein S4; Reviewed; Region: rps4; CHL00113 59922004466 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 59922004467 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 59922004468 RNA binding surface [nucleotide binding]; other site 59922004469 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 59922004470 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 59922004471 homodimer interface [polypeptide binding]; other site 59922004472 substrate-cofactor binding pocket; other site 59922004473 pyridoxal 5'-phosphate binding site [chemical binding]; other site 59922004474 catalytic residue [active] 59922004475 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 59922004476 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 59922004477 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 59922004478 catalytic residue [active] 59922004479 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 59922004480 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 59922004481 dimer interface [polypeptide binding]; other site 59922004482 pyridoxal 5'-phosphate binding site [chemical binding]; other site 59922004483 catalytic residue [active] 59922004484 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 59922004485 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 59922004486 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922004487 TPR repeat; Region: TPR_11; pfam13414 59922004488 binding surface 59922004489 TPR motif; other site 59922004490 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 59922004491 FOG: WD40 repeat [General function prediction only]; Region: COG2319 59922004492 NHL repeat; Region: NHL; pfam01436 59922004493 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 59922004494 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 59922004495 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 59922004496 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 59922004497 E3 interaction surface; other site 59922004498 lipoyl attachment site [posttranslational modification]; other site 59922004499 e3 binding domain; Region: E3_binding; pfam02817 59922004500 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 59922004501 Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326 59922004502 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 59922004503 putative ligand binding site [chemical binding]; other site 59922004504 Ion transport protein; Region: Ion_trans; pfam00520 59922004505 Ion channel; Region: Ion_trans_2; pfam07885 59922004506 TPR repeat; Region: TPR_11; pfam13414 59922004507 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 59922004508 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 59922004509 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 59922004510 acyl-activating enzyme (AAE) consensus motif; other site 59922004511 putative AMP binding site [chemical binding]; other site 59922004512 putative active site [active] 59922004513 putative CoA binding site [chemical binding]; other site 59922004514 lipoate-protein ligase B; Provisional; Region: PRK14344 59922004515 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 59922004516 30S subunit binding site; other site 59922004517 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 59922004518 intersubunit interface [polypeptide binding]; other site 59922004519 active site 59922004520 catalytic residue [active] 59922004521 Recombination protein O N terminal; Region: RecO_N; pfam11967 59922004522 Recombination protein O C terminal; Region: RecO_C; pfam02565 59922004523 H+ Antiporter protein; Region: 2A0121; TIGR00900 59922004524 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 59922004525 putative substrate translocation pore; other site 59922004526 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 59922004527 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 59922004528 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 59922004529 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 59922004530 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 59922004531 Predicted enzyme with a TIM-barrel fold [General function prediction only]; Region: COG0325 59922004532 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 59922004533 catalytic residue [active] 59922004534 Protein of unknown function (DUF3539); Region: DUF3539; pfam12058 59922004535 Cobalt transport protein; Region: CbiQ; cl00463 59922004536 GTP-binding protein Der; Reviewed; Region: PRK00093 59922004537 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 59922004538 G1 box; other site 59922004539 GTP/Mg2+ binding site [chemical binding]; other site 59922004540 Switch I region; other site 59922004541 G2 box; other site 59922004542 Switch II region; other site 59922004543 G3 box; other site 59922004544 G4 box; other site 59922004545 G5 box; other site 59922004546 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 59922004547 G1 box; other site 59922004548 GTP/Mg2+ binding site [chemical binding]; other site 59922004549 Switch I region; other site 59922004550 G2 box; other site 59922004551 G3 box; other site 59922004552 Switch II region; other site 59922004553 G4 box; other site 59922004554 G5 box; other site 59922004555 Domain of unknown function (DUF1823); Region: DUF1823; pfam08853 59922004556 Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862 59922004557 Domain of unknown function (DUF1824); Region: DUF1824; pfam08854 59922004558 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 59922004559 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 59922004560 FMN binding site [chemical binding]; other site 59922004561 active site 59922004562 catalytic residues [active] 59922004563 substrate binding site [chemical binding]; other site 59922004564 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 59922004565 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 59922004566 active site 59922004567 SAM binding site [chemical binding]; other site 59922004568 homodimer interface [polypeptide binding]; other site 59922004569 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 59922004570 Cupin domain; Region: Cupin_2; cl17218 59922004571 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 59922004572 active site 59922004573 dinuclear metal binding site [ion binding]; other site 59922004574 dimerization interface [polypeptide binding]; other site 59922004575 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 59922004576 Dehydroquinase class II; Region: DHquinase_II; pfam01220 59922004577 active site 59922004578 trimer interface [polypeptide binding]; other site 59922004579 dimer interface [polypeptide binding]; other site 59922004580 Protein of unknown function (DUF1651); Region: DUF1651; pfam07864 59922004581 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 59922004582 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 59922004583 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 59922004584 active site 59922004585 homodimer interface [polypeptide binding]; other site 59922004586 catalytic site [active] 59922004587 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 59922004588 nucleotide binding site [chemical binding]; other site 59922004589 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 59922004590 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 59922004591 NAD(P) binding site [chemical binding]; other site 59922004592 catalytic residues [active] 59922004593 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 59922004594 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 59922004595 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 59922004596 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 59922004597 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 59922004598 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 59922004599 ATP-dependent DNA helicase, RecQ family; Region: recQ_fam; TIGR00614 59922004600 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 59922004601 ATP binding site [chemical binding]; other site 59922004602 putative Mg++ binding site [ion binding]; other site 59922004603 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 59922004604 nucleotide binding region [chemical binding]; other site 59922004605 ATP-binding site [chemical binding]; other site 59922004606 photosystem I reaction center subunit IV; Provisional; Region: PRK02749 59922004607 formamidopyrimidine-DNA glycosylase; Provisional; Region: PRK13945 59922004608 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 59922004609 DNA binding site [nucleotide binding] 59922004610 catalytic residue [active] 59922004611 H2TH interface [polypeptide binding]; other site 59922004612 putative catalytic residues [active] 59922004613 turnover-facilitating residue; other site 59922004614 intercalation triad [nucleotide binding]; other site 59922004615 8OG recognition residue [nucleotide binding]; other site 59922004616 putative reading head residues; other site 59922004617 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 59922004618 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 59922004619 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 59922004620 intersubunit interface [polypeptide binding]; other site 59922004621 active site 59922004622 Zn2+ binding site [ion binding]; other site 59922004623 Predicted enolase-phosphatase [Energy production and conversion]; Region: COG4229 59922004624 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 59922004625 active site 59922004626 motif I; other site 59922004627 motif II; other site 59922004628 Alkaline and neutral invertase; Region: Glyco_hydro_100; pfam12899 59922004629 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 59922004630 interchain domain interface [polypeptide binding]; other site 59922004631 intrachain domain interface; other site 59922004632 Qi binding site; other site 59922004633 Qo binding site; other site 59922004634 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 59922004635 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 59922004636 Qi binding site; other site 59922004637 intrachain domain interface; other site 59922004638 interchain domain interface [polypeptide binding]; other site 59922004639 heme bH binding site [chemical binding]; other site 59922004640 heme bL binding site [chemical binding]; other site 59922004641 Qo binding site; other site 59922004642 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 59922004643 C-terminal peptidase (prc); Region: prc; TIGR00225 59922004644 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 59922004645 protein binding site [polypeptide binding]; other site 59922004646 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 59922004647 Catalytic dyad [active] 59922004648 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 59922004649 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 59922004650 Zn2+ binding site [ion binding]; other site 59922004651 Mg2+ binding site [ion binding]; other site 59922004652 septum formation inhibitor; Reviewed; Region: minC; PRK04516 59922004653 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 59922004654 septum site-determining protein MinD; Region: minD_bact; TIGR01968 59922004655 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 59922004656 P-loop; other site 59922004657 ADP binding residues [chemical binding]; other site 59922004658 Switch I; other site 59922004659 Switch II; other site 59922004660 cell division topological specificity factor MinE; Provisional; Region: PRK13988 59922004661 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922004662 binding surface 59922004663 TPR motif; other site 59922004664 TPR repeat; Region: TPR_11; pfam13414 59922004665 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922004666 binding surface 59922004667 TPR repeat; Region: TPR_11; pfam13414 59922004668 TPR motif; other site 59922004669 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 59922004670 active site 59922004671 catalytic residues [active] 59922004672 DNA binding site [nucleotide binding] 59922004673 Int/Topo IB signature motif; other site 59922004674 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 59922004675 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 59922004676 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 59922004677 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 59922004678 DNA protecting protein DprA; Region: dprA; TIGR00732 59922004679 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 59922004680 active site 59922004681 photosystem II reaction center protein M; Provisional; Region: psbM; PRK04989 59922004682 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 59922004683 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 59922004684 catalytic loop [active] 59922004685 iron binding site [ion binding]; other site 59922004686 photosystem II chlorophyll-binding protein CP47; Region: PS_II_CP47; TIGR03039 59922004687 photosystem II reaction center protein T; Reviewed; Region: psbT; PRK11875 59922004688 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 59922004689 ATP cone domain; Region: ATP-cone; pfam03477 59922004690 30S ribosomal protein S1; Reviewed; Region: PRK07400 59922004691 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 59922004692 RNA binding site [nucleotide binding]; other site 59922004693 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 59922004694 RNA binding site [nucleotide binding]; other site 59922004695 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 59922004696 RNA binding site [nucleotide binding]; other site 59922004697 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 59922004698 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 59922004699 motif II; other site 59922004700 S-adenosylmethionine synthetase; Validated; Region: PRK05250 59922004701 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 59922004702 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 59922004703 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 59922004704 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 59922004705 D-xylulose kinase; Region: XylB; TIGR01312 59922004706 nucleotide binding site [chemical binding]; other site 59922004707 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 59922004708 comF family protein; Region: comF; TIGR00201 59922004709 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 59922004710 active site 59922004711 monogalactosyldiacylglycerol synthase; Region: PLN02605 59922004712 CpeS-like protein; Region: CpeS; pfam09367 59922004713 CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206 59922004714 HEAT repeats; Region: HEAT_2; pfam13646 59922004715 HEAT repeats; Region: HEAT_2; pfam13646 59922004716 HEAT repeats; Region: HEAT_2; pfam13646 59922004717 HEAT repeats; Region: HEAT_2; pfam13646 59922004718 HEAT repeats; Region: HEAT_2; pfam13646 59922004719 Phycobilisome protein; Region: Phycobilisome; cl08227 59922004720 Phycobilisome protein; Region: Phycobilisome; cl08227 59922004721 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 59922004722 heme binding pocket [chemical binding]; other site 59922004723 heme ligand [chemical binding]; other site 59922004724 dihydrobiliverdin:ferredoxin oxidoreductase; Provisional; Region: PRK13247 59922004725 phycoerythrobilin:ferredoxin oxidoreductase; Provisional; Region: PRK13249 59922004726 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 59922004727 Low molecular weight phosphatase family; Region: LMWPc; cd00115 59922004728 active site 59922004729 bifunctional pantoate ligase/cytidylate kinase; Provisional; Region: PRK13477 59922004730 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 59922004731 active site 59922004732 nucleotide binding site [chemical binding]; other site 59922004733 HIGH motif; other site 59922004734 KMSKS motif; other site 59922004735 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 59922004736 CMP-binding site; other site 59922004737 The sites determining sugar specificity; other site 59922004738 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 59922004739 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 59922004740 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 59922004741 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 59922004742 dimerization interface [polypeptide binding]; other site 59922004743 putative ATP binding site [chemical binding]; other site 59922004744 TPR repeat; Region: TPR_11; pfam13414 59922004745 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922004746 binding surface 59922004747 TPR motif; other site 59922004748 TPR repeat; Region: TPR_11; pfam13414 59922004749 TPR repeat; Region: TPR_11; pfam13414 59922004750 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 59922004751 catalytic residues [active] 59922004752 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370 59922004753 conserved hypothetical protein; Region: TIGR03492 59922004754 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 59922004755 catalytic site [active] 59922004756 putative active site [active] 59922004757 putative substrate binding site [chemical binding]; other site 59922004758 Protein of unknown function (DUF3529); Region: DUF3529; pfam12046 59922004759 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 59922004760 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 59922004761 Domain of unknown function DUF59; Region: DUF59; pfam01883 59922004762 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 59922004763 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 59922004764 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 59922004765 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 59922004766 dimer interface [polypeptide binding]; other site 59922004767 phosphorylation site [posttranslational modification] 59922004768 PsaD; Region: PsaD; pfam02531 59922004769 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 59922004770 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 59922004771 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 59922004772 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 59922004773 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 59922004774 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 59922004775 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 59922004776 Walker A/P-loop; other site 59922004777 ATP binding site [chemical binding]; other site 59922004778 Q-loop/lid; other site 59922004779 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 59922004780 ABC transporter signature motif; other site 59922004781 Walker B; other site 59922004782 D-loop; other site 59922004783 H-loop/switch region; other site 59922004784 S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK02770 59922004785 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 59922004786 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 59922004787 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 59922004788 Ligand Binding Site [chemical binding]; other site 59922004789 hypothetical protein; Validated; Region: PRK07413 59922004790 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; pfam02572 59922004791 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; pfam02572 59922004792 hypothetical protein; Validated; Region: PRK07411 59922004793 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 59922004794 ATP binding site [chemical binding]; other site 59922004795 substrate interface [chemical binding]; other site 59922004796 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 59922004797 active site residue [active] 59922004798 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 59922004799 MPN+ (JAMM) motif; other site 59922004800 Zinc-binding site [ion binding]; other site 59922004801 Domain of unknown function (DUF4308); Region: DUF4308; pfam14159 59922004802 Fructosamine kinase; Region: Fructosamin_kin; cl17579 59922004803 Phosphotransferase enzyme family; Region: APH; pfam01636 59922004804 C-3',4' desaturase CrtD; Region: desat_CrtD; TIGR02733 59922004805 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 59922004806 arogenate dehydrogenase; Reviewed; Region: PRK07417 59922004807 prephenate dehydrogenase; Validated; Region: PRK08507 59922004808 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 59922004809 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 59922004810 Protein of unknown function (DUF2839); Region: DUF2839; pfam10999 59922004811 recombinase A; Provisional; Region: recA; PRK09354 59922004812 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 59922004813 hexamer interface [polypeptide binding]; other site 59922004814 Walker A motif; other site 59922004815 ATP binding site [chemical binding]; other site 59922004816 Walker B motif; other site 59922004817 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 59922004818 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 59922004819 motif II; other site 59922004820 ncharacterized protein conserved in bacteria [Function unknown]; Region: SpoIIIAA; COG3854 59922004821 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 59922004822 Walker A motif; other site 59922004823 ATP binding site [chemical binding]; other site 59922004824 Walker B motif; other site 59922004825 R3H domain of a group of proteins with unknown function, who also contain a AAA-ATPase (AAA) domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is...; Region: R3H_AAA; cd02645 59922004826 RxxxH motif; other site 59922004827 Iron-Sulfur binding protein C terminal; Region: LdpA_C; pfam12617 59922004828 NADH-quinone oxidoreductase cyanobacterial subunit N; Region: NdhN; pfam11909 59922004829 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 59922004830 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 59922004831 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 59922004832 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 59922004833 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 59922004834 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 59922004835 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 59922004836 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 59922004837 putative translocon binding site; other site 59922004838 protein-rRNA interface [nucleotide binding]; other site 59922004839 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 59922004840 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 59922004841 G-X-X-G motif; other site 59922004842 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 59922004843 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 59922004844 23S rRNA interface [nucleotide binding]; other site 59922004845 5S rRNA interface [nucleotide binding]; other site 59922004846 putative antibiotic binding site [chemical binding]; other site 59922004847 L25 interface [polypeptide binding]; other site 59922004848 L27 interface [polypeptide binding]; other site 59922004849 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 59922004850 23S rRNA interface [nucleotide binding]; other site 59922004851 putative translocon interaction site; other site 59922004852 signal recognition particle (SRP54) interaction site; other site 59922004853 L23 interface [polypeptide binding]; other site 59922004854 trigger factor interaction site; other site 59922004855 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 59922004856 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 59922004857 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 59922004858 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 59922004859 RNA binding site [nucleotide binding]; other site 59922004860 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 59922004861 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 59922004862 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 59922004863 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 59922004864 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 59922004865 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 59922004866 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 59922004867 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 59922004868 5S rRNA interface [nucleotide binding]; other site 59922004869 L27 interface [polypeptide binding]; other site 59922004870 23S rRNA interface [nucleotide binding]; other site 59922004871 L5 interface [polypeptide binding]; other site 59922004872 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 59922004873 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 59922004874 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 59922004875 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 59922004876 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 59922004877 SecY translocase; Region: SecY; pfam00344 59922004878 adenylate kinase; Provisional; Region: PRK14531 59922004879 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 59922004880 AMP-binding site [chemical binding]; other site 59922004881 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 59922004882 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 59922004883 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 59922004884 30S ribosomal protein S13; Region: bact_S13; TIGR03631 59922004885 30S ribosomal protein S11; Validated; Region: PRK05309 59922004886 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 59922004887 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 59922004888 alphaNTD homodimer interface [polypeptide binding]; other site 59922004889 alphaNTD - beta interaction site [polypeptide binding]; other site 59922004890 alphaNTD - beta' interaction site [polypeptide binding]; other site 59922004891 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 59922004892 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 59922004893 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 59922004894 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 59922004895 dimerization interface 3.5A [polypeptide binding]; other site 59922004896 active site 59922004897 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 59922004898 23S rRNA interface [nucleotide binding]; other site 59922004899 L3 interface [polypeptide binding]; other site 59922004900 ribosomal protein S9; Region: rps9; CHL00079 59922004901 ribosomal protein L31; Validated; Region: rpl31; CHL00136 59922004902 peptide chain release factor 1; Validated; Region: prfA; PRK00591 59922004903 This domain is found in peptide chain release factors; Region: PCRF; smart00937 59922004904 RF-1 domain; Region: RF-1; pfam00472 59922004905 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 59922004906 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 59922004907 active site 59922004908 alanine racemase; Reviewed; Region: alr; PRK00053 59922004909 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 59922004910 active site 59922004911 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 59922004912 dimer interface [polypeptide binding]; other site 59922004913 substrate binding site [chemical binding]; other site 59922004914 catalytic residues [active] 59922004915 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 59922004916 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 59922004917 NAD(P) binding site [chemical binding]; other site 59922004918 active site 59922004919 Class I aldolases; Region: Aldolase_Class_I; cl17187 59922004920 catalytic residue [active] 59922004921 Class I aldolases; Region: Aldolase_Class_I; cl17187 59922004922 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 59922004923 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 59922004924 NlpC/P60 family; Region: NLPC_P60; pfam00877 59922004925 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 59922004926 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 59922004927 Ligand binding site; other site 59922004928 Putative Catalytic site; other site 59922004929 DXD motif; other site 59922004930 photosystem I reaction center subunit VIII; Reviewed; Region: psaI; PRK11877 59922004931 photosystem I reaction center protein subunit XI; Provisional; Region: PRK00704 59922004932 photosystem I P700 chlorophyll a apoprotein A2; Provisional; Region: psaB; PRK13199 59922004933 photosystem I P700 chlorophyll a apoprotein A1; Provisional; Region: psaA; PRK13200 59922004934 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 59922004935 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 59922004936 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 59922004937 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 59922004938 active site 59922004939 SAM binding site [chemical binding]; other site 59922004940 homodimer interface [polypeptide binding]; other site 59922004941 lycopene cyclase family protein; Region: carotene-cycl; TIGR01790 59922004942 lipoyl synthase; Provisional; Region: PRK05481 59922004943 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 59922004944 FeS/SAM binding site; other site 59922004945 YCII-related domain; Region: YCII; cl00999 59922004946 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 59922004947 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 59922004948 active site 59922004949 dimer interface [polypeptide binding]; other site 59922004950 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 59922004951 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 59922004952 active site 59922004953 FMN binding site [chemical binding]; other site 59922004954 substrate binding site [chemical binding]; other site 59922004955 3Fe-4S cluster binding site [ion binding]; other site 59922004956 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 59922004957 domain interface; other site 59922004958 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 59922004959 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 59922004960 S17 interaction site [polypeptide binding]; other site 59922004961 S8 interaction site; other site 59922004962 16S rRNA interaction site [nucleotide binding]; other site 59922004963 streptomycin interaction site [chemical binding]; other site 59922004964 23S rRNA interaction site [nucleotide binding]; other site 59922004965 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 59922004966 30S ribosomal protein S7; Validated; Region: PRK05302 59922004967 elongation factor G; Reviewed; Region: PRK00007 59922004968 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 59922004969 G1 box; other site 59922004970 putative GEF interaction site [polypeptide binding]; other site 59922004971 GTP/Mg2+ binding site [chemical binding]; other site 59922004972 Switch I region; other site 59922004973 G2 box; other site 59922004974 G3 box; other site 59922004975 Switch II region; other site 59922004976 G4 box; other site 59922004977 G5 box; other site 59922004978 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 59922004979 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 59922004980 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 59922004981 elongation factor Tu; Reviewed; Region: PRK00049 59922004982 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 59922004983 G1 box; other site 59922004984 GEF interaction site [polypeptide binding]; other site 59922004985 GTP/Mg2+ binding site [chemical binding]; other site 59922004986 Switch I region; other site 59922004987 G2 box; other site 59922004988 G3 box; other site 59922004989 Switch II region; other site 59922004990 G4 box; other site 59922004991 G5 box; other site 59922004992 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 59922004993 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 59922004994 Antibiotic Binding Site [chemical binding]; other site 59922004995 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 59922004996 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 59922004997 tocopherol O-methyltransferase; Region: PLN02244 59922004998 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 59922004999 S-adenosylmethionine binding site [chemical binding]; other site 59922005000 prephenate dehydratase; Provisional; Region: PRK11898 59922005001 Prephenate dehydratase; Region: PDT; pfam00800 59922005002 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 59922005003 putative L-Phe binding site [chemical binding]; other site 59922005004 Protein of unknown function (DUF1997); Region: DUF1997; pfam09366 59922005005 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 59922005006 RNA/DNA hybrid binding site [nucleotide binding]; other site 59922005007 active site 59922005008 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 59922005009 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 59922005010 homodimer interface [polypeptide binding]; other site 59922005011 oligonucleotide binding site [chemical binding]; other site 59922005012 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 59922005013 B12 binding site [chemical binding]; other site 59922005014 L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590 59922005015 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 59922005016 pyridoxal 5'-phosphate binding site [chemical binding]; other site 59922005017 homodimer interface [polypeptide binding]; other site 59922005018 catalytic residue [active] 59922005019 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 59922005020 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 59922005021 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 59922005022 FeS/SAM binding site; other site 59922005023 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 59922005024 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 59922005025 Tetramer interface [polypeptide binding]; other site 59922005026 active site 59922005027 FMN-binding site [chemical binding]; other site 59922005028 FtsH Extracellular; Region: FtsH_ext; pfam06480 59922005029 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 59922005030 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 59922005031 Walker A motif; other site 59922005032 ATP binding site [chemical binding]; other site 59922005033 Walker B motif; other site 59922005034 arginine finger; other site 59922005035 Peptidase family M41; Region: Peptidase_M41; pfam01434 59922005036 ATP sulphurylase; Region: sopT; TIGR00339 59922005037 ATP-sulfurylase; Region: ATPS; cd00517 59922005038 active site 59922005039 HXXH motif; other site 59922005040 flexible loop; other site 59922005041 Manganese-stabilising protein / photosystem II polypeptide; Region: MSP; cl03326 59922005042 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 59922005043 Flavoprotein; Region: Flavoprotein; pfam02441 59922005044 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 59922005045 Protein of unknown function (DUF2555); Region: DUF2555; pfam10742 59922005046 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 59922005047 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 59922005048 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 59922005049 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 59922005050 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 59922005051 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 59922005052 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 59922005053 active site 59922005054 DNA binding site [nucleotide binding] 59922005055 Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862 59922005056 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 59922005057 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922005058 binding surface 59922005059 TPR motif; other site 59922005060 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922005061 binding surface 59922005062 TPR motif; other site 59922005063 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922005064 binding surface 59922005065 TPR motif; other site 59922005066 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 59922005067 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 59922005068 active site 59922005069 DNA binding site [nucleotide binding] 59922005070 Int/Topo IB signature motif; other site 59922005071 Carboxy-terminal domain of Formyltransferase and similar domains; Region: FMT_C_like; cl14785 59922005072 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 59922005073 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922005074 binding surface 59922005075 TPR motif; other site 59922005076 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922005077 binding surface 59922005078 TPR motif; other site 59922005079 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922005080 binding surface 59922005081 TPR motif; other site 59922005082 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 59922005083 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922005084 TPR motif; other site 59922005085 binding surface 59922005086 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922005087 binding surface 59922005088 TPR motif; other site 59922005089 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922005090 binding surface 59922005091 TPR motif; other site 59922005092 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922005093 binding surface 59922005094 TPR motif; other site 59922005095 Tetratricopeptide repeat; Region: TPR_12; pfam13424 59922005096 Carboxy-terminal domain of Formyltransferase and similar domains; Region: FMT_C_like; cl14785 59922005097 Tetratricopeptide repeat; Region: TPR_16; pfam13432 59922005098 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922005099 binding surface 59922005100 TPR motif; other site 59922005101 TPR repeat; Region: TPR_11; pfam13414 59922005102 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922005103 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 59922005104 TPR motif; other site 59922005105 binding surface 59922005106 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922005107 binding surface 59922005108 TPR motif; other site 59922005109 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922005110 binding surface 59922005111 TPR motif; other site 59922005112 Tetratricopeptide repeat; Region: TPR_17; pfam13431 59922005113 DNA primase; Provisional; Region: 61; PHA02540 59922005114 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 59922005115 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922005116 binding surface 59922005117 TPR motif; other site 59922005118 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922005119 binding surface 59922005120 TPR motif; other site 59922005121 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922005122 binding surface 59922005123 TPR motif; other site 59922005124 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922005125 binding surface 59922005126 TPR motif; other site 59922005127 Tetratricopeptide repeat; Region: TPR_12; pfam13424 59922005128 TPR repeat; Region: TPR_11; pfam13414 59922005129 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922005130 TPR motif; other site 59922005131 binding surface 59922005132 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 59922005133 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922005134 binding surface 59922005135 TPR motif; other site 59922005136 Tetratricopeptide repeats; Region: TPR; smart00028 59922005137 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922005138 binding surface 59922005139 TPR motif; other site 59922005140 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922005141 binding surface 59922005142 Tetratricopeptide repeat; Region: TPR_16; pfam13432 59922005143 TPR motif; other site 59922005144 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 59922005145 active site 59922005146 DNA binding site [nucleotide binding] 59922005147 Tetratricopeptide repeat; Region: TPR_16; pfam13432 59922005148 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922005149 binding surface 59922005150 TPR motif; other site 59922005151 TPR repeat; Region: TPR_11; pfam13414 59922005152 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922005153 binding surface 59922005154 TPR motif; other site 59922005155 Tetratricopeptide repeat; Region: TPR_16; pfam13432 59922005156 TPR repeat; Region: TPR_11; pfam13414 59922005157 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922005158 binding surface 59922005159 Tetratricopeptide repeat; Region: TPR_16; pfam13432 59922005160 TPR motif; other site 59922005161 Carboxy-terminal domain of Formyltransferase and similar domains; Region: FMT_C_like; cl14785 59922005162 Protein of unknown function, DUF481; Region: DUF481; cl01213 59922005163 Creatinine amidohydrolase; Region: Creatininase; pfam02633 59922005164 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 59922005165 Beta-carotene hydroxylase (CrtR), the carotenoid zeaxanthin biosynthetic enzyme catalyzes the addition of hydroxyl groups to the beta-ionone rings of beta-carotene to form zeaxanthin and is found in bacteria and red algae. Carotenoids are important...; Region: CrtR_beta-carotene-hydroxylase; cd03514 59922005166 Fatty acid desaturase; Region: FA_desaturase; pfam00487 59922005167 putative di-iron ligands [ion binding]; other site 59922005168 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 59922005169 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 59922005170 active site 59922005171 HIGH motif; other site 59922005172 nucleotide binding site [chemical binding]; other site 59922005173 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 59922005174 active site 59922005175 KMSKS motif; other site 59922005176 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 59922005177 tRNA binding surface [nucleotide binding]; other site 59922005178 anticodon binding site; other site 59922005179 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 59922005180 Protein of unknown function (DUF3177); Region: DUF3177; pfam11375 59922005181 FIST N domain; Region: FIST; smart00897 59922005182 FIST C domain; Region: FIST_C; pfam10442 59922005183 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 59922005184 S-adenosylmethionine binding site [chemical binding]; other site 59922005185 putative bicarbonate transporter, IctB family; Region: 2A73; TIGR00947 59922005186 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 59922005187 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 59922005188 nucleotide binding site [chemical binding]; other site 59922005189 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14317 59922005190 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 59922005191 active site 59922005192 substrate binding site [chemical binding]; other site 59922005193 metal binding site [ion binding]; metal-binding site 59922005194 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 59922005195 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 59922005196 N-acetyl-D-glucosamine binding site [chemical binding]; other site 59922005197 catalytic residue [active] 59922005198 TRX-like protein A (TxlA) family; TxlA was originally isolated from the cyanobacterium Synechococcus. It is found only in oxygenic photosynthetic organisms. TRX is a small enzyme that participate in redox reactions, via the reversible oxidation of an...; Region: TxlA; cd02950 59922005199 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 59922005200 catalytic residues [active] 59922005201 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 59922005202 trimer interface [polypeptide binding]; other site 59922005203 active site 59922005204 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 59922005205 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; cl17276 59922005206 ribonuclease PH; Reviewed; Region: rph; PRK00173 59922005207 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 59922005208 oligomer interface [polypeptide binding]; other site 59922005209 RNA binding site [nucleotide binding]; other site 59922005210 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 59922005211 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 59922005212 ligand binding site [chemical binding]; other site 59922005213 flexible hinge region; other site 59922005214 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 59922005215 putative switch regulator; other site 59922005216 non-specific DNA interactions [nucleotide binding]; other site 59922005217 DNA binding site [nucleotide binding] 59922005218 sequence specific DNA binding site [nucleotide binding]; other site 59922005219 putative cAMP binding site [chemical binding]; other site 59922005220 Protein of unknown function (DUF3084); Region: DUF3084; pfam11283 59922005221 Uncharacterized protein conserved in bacteria with the myosin-like domain [Function unknown]; Region: COG4372 59922005222 Uncharacterized protein family (UPF0081); Region: UPF0081; cl17278 59922005223 Protein of unknown function (DUF3146); Region: DUF3146; pfam11344 59922005224 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 59922005225 putative active site [active] 59922005226 catalytic residue [active] 59922005227 twin arginine translocase protein A; Provisional; Region: tatA; PRK14857 59922005228 photosystem II reaction center protein H; Provisional; Region: psbH; PRK02624 59922005229 photosystem II reaction center protein N; Provisional; Region: psbN; PRK13183 59922005230 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 59922005231 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 59922005232 active site 59922005233 catalytic site [active] 59922005234 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; pfam09261 59922005235 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 59922005236 photosystem II reaction center I protein I; Provisional; Region: psbI; PRK02655 59922005237 Protein of unknown function (DUF3769); Region: DUF3769; pfam12600 59922005238 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 59922005239 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 59922005240 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 59922005241 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 59922005242 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 59922005243 substrate binding site [chemical binding]; other site 59922005244 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 59922005245 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 59922005246 substrate binding site [chemical binding]; other site 59922005247 ligand binding site [chemical binding]; other site 59922005248 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 59922005249 competence damage-inducible protein A; Provisional; Region: PRK00549 59922005250 putative MPT binding site; other site 59922005251 Competence-damaged protein; Region: CinA; pfam02464 59922005252 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 59922005253 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 59922005254 Mg++ binding site [ion binding]; other site 59922005255 putative catalytic motif [active] 59922005256 substrate binding site [chemical binding]; other site 59922005257 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 59922005258 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 59922005259 dimer interface [polypeptide binding]; other site 59922005260 active site 59922005261 glycine-pyridoxal phosphate binding site [chemical binding]; other site 59922005262 folate binding site [chemical binding]; other site 59922005263 Protein of unknown function (DUF3181); Region: DUF3181; pfam11378 59922005264 transferase, transferring glycosyl groups; Region: PLN02275 59922005265 integral membrane protein MviN; Region: mviN; TIGR01695 59922005266 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 59922005267 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 59922005268 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 59922005269 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Provisional; Region: PRK13371 59922005270 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 59922005271 Protein of unknown function (DUF1997); Region: DUF1997; pfam09366 59922005272 DoxX; Region: DoxX; pfam07681 59922005273 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 59922005274 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 59922005275 purine monophosphate binding site [chemical binding]; other site 59922005276 dimer interface [polypeptide binding]; other site 59922005277 putative catalytic residues [active] 59922005278 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 59922005279 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 59922005280 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 59922005281 putative hydrolase; Provisional; Region: PRK11460 59922005282 Protein of unknown function (DUF3155); Region: DUF3155; pfam11352 59922005283 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 59922005284 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 59922005285 dimer interface [polypeptide binding]; other site 59922005286 phosphorylation site [posttranslational modification] 59922005287 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 59922005288 ATP binding site [chemical binding]; other site 59922005289 Mg2+ binding site [ion binding]; other site 59922005290 G-X-G motif; other site 59922005291 cobalamin synthase; Reviewed; Region: cobS; PRK00235 59922005292 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 59922005293 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 59922005294 photosystem II reaction center protein K; Provisional; Region: psbK; PRK02553 59922005295 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 59922005296 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 59922005297 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 59922005298 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 59922005299 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 59922005300 Domain of unknown function DUF21; Region: DUF21; pfam01595 59922005301 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 59922005302 Transporter associated domain; Region: CorC_HlyC; smart01091 59922005303 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 59922005304 active site 59922005305 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 59922005306 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 59922005307 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 59922005308 RecB family nuclease, putative, TM0106 family; Region: TIGR03491 59922005309 RNase_H superfamily; Region: RNase_H_2; pfam13482 59922005310 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 59922005311 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 59922005312 active site 59922005313 substrate binding site [chemical binding]; other site 59922005314 metal binding site [ion binding]; metal-binding site 59922005315 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 59922005316 active site 59922005317 dimerization interface [polypeptide binding]; other site 59922005318 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 59922005319 putative substrate translocation pore; other site 59922005320 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 59922005321 Retinal pigment epithelial membrane protein; Region: RPE65; cl10080 59922005322 Protein of unknown function (DUF541); Region: SIMPL; cl01077 59922005323 Retinal pigment epithelial membrane protein; Region: RPE65; cl10080 59922005324 Protein of unknown function (DUF541); Region: SIMPL; cl01077 59922005325 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 59922005326 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 59922005327 imidazoleglycerol-phosphate dehydratase; Region: PLN02800 59922005328 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 59922005329 putative active site pocket [active] 59922005330 4-fold oligomerization interface [polypeptide binding]; other site 59922005331 metal binding residues [ion binding]; metal-binding site 59922005332 3-fold/trimer interface [polypeptide binding]; other site 59922005333 enoyl-(acyl carrier protein) reductase; Validated; Region: PRK07370 59922005334 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 59922005335 NAD binding site [chemical binding]; other site 59922005336 homotetramer interface [polypeptide binding]; other site 59922005337 homodimer interface [polypeptide binding]; other site 59922005338 substrate binding site [chemical binding]; other site 59922005339 active site 59922005340 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 59922005341 putative catalytic residue [active] 59922005342 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 59922005343 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 59922005344 inhibitor-cofactor binding pocket; inhibition site 59922005345 pyridoxal 5'-phosphate binding site [chemical binding]; other site 59922005346 catalytic residue [active] 59922005347 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 59922005348 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 59922005349 dimer interface [polypeptide binding]; other site 59922005350 ADP-ribose binding site [chemical binding]; other site 59922005351 active site 59922005352 nudix motif; other site 59922005353 metal binding site [ion binding]; metal-binding site 59922005354 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 59922005355 catalytic center binding site [active] 59922005356 ATP binding site [chemical binding]; other site 59922005357 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 59922005358 magnesium chelatase ATPase subunit D; Region: BchD-ChlD; TIGR02031 59922005359 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 59922005360 metal ion-dependent adhesion site (MIDAS); other site 59922005361 Substrate binding subunit of ER-derived-lipid transporter; Provisional; Region: PLN03094 59922005362 mce related protein; Region: MCE; pfam02470 59922005363 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 59922005364 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 59922005365 Walker A/P-loop; other site 59922005366 ATP binding site [chemical binding]; other site 59922005367 Q-loop/lid; other site 59922005368 ABC transporter signature motif; other site 59922005369 Walker B; other site 59922005370 D-loop; other site 59922005371 H-loop/switch region; other site 59922005372 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 59922005373 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 59922005374 phosphate binding site [ion binding]; other site 59922005375 putative substrate binding pocket [chemical binding]; other site 59922005376 dimer interface [polypeptide binding]; other site 59922005377 NADH dehydrogenase subunit J; Provisional; Region: PRK12494 59922005378 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 59922005379 NADH dehydrogenase subunit K; Region: ndhK; CHL00023 59922005380 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 59922005381 Rubredoxin [Energy production and conversion]; Region: COG1773 59922005382 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 59922005383 iron binding site [ion binding]; other site 59922005384 Ycf48-like protein; Provisional; Region: PRK13684 59922005385 cytochrome b559 subunit alpha; Provisional; Region: psbE; PRK02557 59922005386 Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits; Region: Cytochrom_B559; pfam00283 59922005387 Lumenal portion of Cytochrome b559, alpha (gene psbE) subunit; Region: Cytochrom_B559a; pfam00284 59922005388 cytochrome b559 subunit beta; Provisional; Region: psbF; PRK02561 59922005389 photosystem II reaction center protein J; Provisional; Region: PRK02565 59922005390 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 59922005391 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 59922005392 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 59922005393 short chain dehydrogenase; Validated; Region: PRK08324 59922005394 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 59922005395 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 59922005396 NAD(P) binding site [chemical binding]; other site 59922005397 active site 59922005398 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 59922005399 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 59922005400 putative NAD(P) binding site [chemical binding]; other site 59922005401 active site 59922005402 putative substrate binding site [chemical binding]; other site 59922005403 probable UDP-glucose 6-dehydrogenase; Region: PLN02353 59922005404 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 59922005405 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 59922005406 histidyl-tRNA synthetase; Region: hisS; TIGR00442 59922005407 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 59922005408 dimer interface [polypeptide binding]; other site 59922005409 motif 1; other site 59922005410 active site 59922005411 motif 2; other site 59922005412 motif 3; other site 59922005413 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 59922005414 anticodon binding site; other site 59922005415 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 59922005416 UDP-glucose 4-epimerase; Region: PLN02240 59922005417 NAD binding site [chemical binding]; other site 59922005418 homodimer interface [polypeptide binding]; other site 59922005419 active site 59922005420 substrate binding site [chemical binding]; other site 59922005421 Bacterial sugar transferase; Region: Bac_transf; pfam02397 59922005422 pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169 59922005423 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 59922005424 dimerization interface [polypeptide binding]; other site 59922005425 putative ATP binding site [chemical binding]; other site 59922005426 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 59922005427 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 59922005428 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 59922005429 active site 59922005430 NTP binding site [chemical binding]; other site 59922005431 metal binding triad [ion binding]; metal-binding site 59922005432 KpsF/GutQ family protein; Region: kpsF; TIGR00393 59922005433 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 59922005434 putative active site [active] 59922005435 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 59922005436 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 59922005437 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 59922005438 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 59922005439 Ligand binding site; other site 59922005440 oligomer interface; other site 59922005441 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 59922005442 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 59922005443 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 59922005444 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 59922005445 Part of AAA domain; Region: AAA_19; pfam13245 59922005446 Family description; Region: UvrD_C_2; pfam13538 59922005447 O-Antigen ligase; Region: Wzy_C; pfam04932 59922005448 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_7; cd05844 59922005449 putative ADP-binding pocket [chemical binding]; other site 59922005450 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 59922005451 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 59922005452 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 59922005453 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 59922005454 putative ADP-binding pocket [chemical binding]; other site 59922005455 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 59922005456 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 59922005457 putative ADP-binding pocket [chemical binding]; other site 59922005458 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 59922005459 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 59922005460 putative homodimer interface [polypeptide binding]; other site 59922005461 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 59922005462 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 59922005463 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 59922005464 Walker A/P-loop; other site 59922005465 ATP binding site [chemical binding]; other site 59922005466 Q-loop/lid; other site 59922005467 ABC transporter signature motif; other site 59922005468 Walker B; other site 59922005469 D-loop; other site 59922005470 H-loop/switch region; other site 59922005471 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 59922005472 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 59922005473 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 59922005474 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl17299 59922005475 heme ligand [chemical binding]; other site 59922005476 Predicted membrane protein [Function unknown]; Region: COG2246 59922005477 GtrA-like protein; Region: GtrA; pfam04138 59922005478 uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_3; cd10807 59922005479 putative active site [active] 59922005480 YdjC motif; other site 59922005481 Mg binding site [ion binding]; other site 59922005482 putative homodimer interface [polypeptide binding]; other site 59922005483 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 59922005484 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 59922005485 Ligand binding site; other site 59922005486 Putative Catalytic site; other site 59922005487 DXD motif; other site 59922005488 isocitrate dehydrogenase; Validated; Region: PRK07362 59922005489 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 59922005490 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 59922005491 Cysteine-rich domain; Region: CCG; pfam02754 59922005492 Cysteine-rich domain; Region: CCG; pfam02754 59922005493 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 59922005494 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 59922005495 FAD binding domain; Region: FAD_binding_4; pfam01565 59922005496 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 59922005497 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 59922005498 catalytic residues [active] 59922005499 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 59922005500 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 59922005501 catalytic residues [active] 59922005502 Aldose 1-epimerase, similar to Synechocystis Slr1438; Region: Aldose_epim_Slr1438; cd09025 59922005503 active site 59922005504 catalytic residues [active] 59922005505 hydrolase, alpha/beta fold family protein; Region: PLN02824 59922005506 Partial alpha/beta-hydrolase lipase region; Region: Abhydro_lipase; pfam04083 59922005507 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 59922005508 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 59922005509 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 59922005510 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 59922005511 homodimer interface [polypeptide binding]; other site 59922005512 active site pocket [active] 59922005513 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 59922005514 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 59922005515 dimerization interface [polypeptide binding]; other site 59922005516 active site 59922005517 metal binding site [ion binding]; metal-binding site 59922005518 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 59922005519 dsRNA binding site [nucleotide binding]; other site 59922005520 Protein of unknown function (DUF3252); Region: DUF3252; pfam11623 59922005521 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 59922005522 RimM N-terminal domain; Region: RimM; pfam01782 59922005523 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 59922005524 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 59922005525 Substrate binding site; other site 59922005526 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 59922005527 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 59922005528 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 59922005529 glutaminase active site [active] 59922005530 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 59922005531 dimer interface [polypeptide binding]; other site 59922005532 active site 59922005533 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 59922005534 dimer interface [polypeptide binding]; other site 59922005535 active site 59922005536 photosystem I subunit VII; Region: psaC; CHL00065 59922005537 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 59922005538 acyl carrier protein; Provisional; Region: acpP; PRK00982 59922005539 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 59922005540 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 59922005541 dimer interface [polypeptide binding]; other site 59922005542 active site 59922005543 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 59922005544 transketolase; Region: PLN02790 59922005545 TPP-binding site [chemical binding]; other site 59922005546 dimer interface [polypeptide binding]; other site 59922005547 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 59922005548 PYR/PP interface [polypeptide binding]; other site 59922005549 dimer interface [polypeptide binding]; other site 59922005550 TPP binding site [chemical binding]; other site 59922005551 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 59922005552 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 59922005553 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 59922005554 NAD binding site [chemical binding]; other site 59922005555 putative substrate binding site 2 [chemical binding]; other site 59922005556 putative substrate binding site 1 [chemical binding]; other site 59922005557 active site 59922005558 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 59922005559 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 59922005560 Ligand binding site; other site 59922005561 Putative Catalytic site; other site 59922005562 DXD motif; other site 59922005563 GtrA-like protein; Region: GtrA; pfam04138 59922005564 Protein of unknown function (DUF3571); Region: DUF3571; pfam12095 59922005565 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 59922005566 maleylacetoacetate isomerase; Region: maiA; TIGR01262 59922005567 C-terminal domain interface [polypeptide binding]; other site 59922005568 GSH binding site (G-site) [chemical binding]; other site 59922005569 dimer interface [polypeptide binding]; other site 59922005570 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 59922005571 N-terminal domain interface [polypeptide binding]; other site 59922005572 Protein of unknown function (DUF751); Region: DUF751; pfam05421 59922005573 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 59922005574 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 59922005575 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 59922005576 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 59922005577 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 59922005578 putative metal binding site; other site 59922005579 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 59922005580 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922005581 binding surface 59922005582 TPR motif; other site 59922005583 TPR repeat; Region: TPR_11; pfam13414 59922005584 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 59922005585 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 59922005586 active site 59922005587 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 59922005588 putative hydrophobic ligand binding site [chemical binding]; other site 59922005589 9,9'-di-cis-zeta-carotene desaturase; Region: zeta_caro_desat; TIGR02732 59922005590 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 59922005591 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 59922005592 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 59922005593 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370 59922005594 conserved hypothetical protein; Region: TIGR03492 59922005595 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 59922005596 TIGR01777 family protein; Region: yfcH 59922005597 putative NAD(P) binding site [chemical binding]; other site 59922005598 putative active site [active] 59922005599 potassium/proton antiporter; Reviewed; Region: PRK05326 59922005600 Cyanobacterial and plant NDH-1 subunit O; Region: NdhO; pfam11910 59922005601 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 59922005602 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 59922005603 HSP70 interaction site [polypeptide binding]; other site 59922005604 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 59922005605 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 59922005606 dimer interface [polypeptide binding]; other site 59922005607 pyridoxal 5'-phosphate binding site [chemical binding]; other site 59922005608 catalytic residue [active] 59922005609 S-layer homology domain; Region: SLH; pfam00395 59922005610 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 59922005611 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 59922005612 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 59922005613 Predicted membrane protein [Function unknown]; Region: COG3463 59922005614 Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852 59922005615 Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852 59922005616 Predicted membrane protein [Function unknown]; Region: COG3463 59922005617 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 59922005618 hypothetical protein; Provisional; Region: PRK13683 59922005619 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 59922005620 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 59922005621 Walker A/P-loop; other site 59922005622 ATP binding site [chemical binding]; other site 59922005623 Q-loop/lid; other site 59922005624 ABC transporter signature motif; other site 59922005625 Walker B; other site 59922005626 D-loop; other site 59922005627 H-loop/switch region; other site 59922005628 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 59922005629 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 59922005630 active site 59922005631 phosphorylation site [posttranslational modification] 59922005632 intermolecular recognition site; other site 59922005633 dimerization interface [polypeptide binding]; other site 59922005634 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 59922005635 DNA binding site [nucleotide binding] 59922005636 DNA polymerase III subunit delta'; Validated; Region: PRK07399 59922005637 DNA polymerase III subunit delta'; Validated; Region: PRK08485 59922005638 thymidylate kinase; Validated; Region: tmk; PRK00698 59922005639 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 59922005640 TMP-binding site; other site 59922005641 ATP-binding site [chemical binding]; other site 59922005642 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 59922005643 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 59922005644 metal-binding site [ion binding] 59922005645 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 59922005646 photosystem I assembly protein Ycf3; Provisional; Region: PRK02603 59922005647 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922005648 binding surface 59922005649 TPR motif; other site 59922005650 DNA repair protein RadA; Provisional; Region: PRK11823 59922005651 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 59922005652 Walker A motif; other site 59922005653 ATP binding site [chemical binding]; other site 59922005654 Walker B motif; other site 59922005655 Ycf27; Reviewed; Region: orf27; CHL00148 59922005656 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 59922005657 active site 59922005658 phosphorylation site [posttranslational modification] 59922005659 intermolecular recognition site; other site 59922005660 dimerization interface [polypeptide binding]; other site 59922005661 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 59922005662 DNA binding site [nucleotide binding] 59922005663 putative glycerol-3-phosphate acyltransferase PlsX; Provisional; Region: PRK13845 59922005664 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 59922005665 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 59922005666 dimer interface [polypeptide binding]; other site 59922005667 active site 59922005668 CoA binding pocket [chemical binding]; other site 59922005669 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 59922005670 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 59922005671 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 59922005672 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 59922005673 putative acyl-acceptor binding pocket; other site 59922005674 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 59922005675 putative active site [active] 59922005676 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 59922005677 Hypothetical chloroplast protein Ycf34; Region: Ycf34; pfam10718 59922005678 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 59922005679 active site 59922005680 NTP binding site [chemical binding]; other site 59922005681 metal binding triad [ion binding]; metal-binding site 59922005682 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 59922005683 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 59922005684 active site lid residues [active] 59922005685 substrate binding pocket [chemical binding]; other site 59922005686 catalytic residues [active] 59922005687 substrate-Mg2+ binding site; other site 59922005688 aspartate-rich region 1; other site 59922005689 aspartate-rich region 2; other site 59922005690 phytoene desaturase; Region: phytoene_desat; TIGR02731 59922005691 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 59922005692 Cyanobacterial and plastid NDH-1 subunit M; Region: NdhM; pfam10664 59922005693 Protein of unknown function (DUF3172); Region: DUF3172; pfam11371 59922005694 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 59922005695 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 59922005696 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 59922005697 putative dimerization interface [polypeptide binding]; other site 59922005698 Predicted membrane protein [Function unknown]; Region: COG4094 59922005699 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07376 59922005700 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 59922005701 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 59922005702 NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010 59922005703 NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK02546 59922005704 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 59922005705 ScpA/B protein; Region: ScpA_ScpB; cl00598 59922005706 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 59922005707 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 59922005708 active site 59922005709 Substrate binding site; other site 59922005710 Mg++ binding site; other site 59922005711 Left-handed parallel beta-Helix (LbH) domain of a group of proteins with similarity to glucose-1-phosphate adenylyltransferase: Included in this family are glucose-1-phosphate adenylyltransferase, mannose-1-phosphate guanylyltransferase, and the...; Region: LbH_G1P_AT_C_like; cd03356 59922005712 rod shape-determining protein MreC; Provisional; Region: PRK13922 59922005713 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 59922005714 nif11-like leader peptide domain; Region: ocin_TIGR03798 59922005715 Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862 59922005716 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 59922005717 active site 59922005718 catalytic residues [active] 59922005719 DNA binding site [nucleotide binding] 59922005720 Int/Topo IB signature motif; other site 59922005721 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 59922005722 FAD binding site [chemical binding]; other site 59922005723 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 59922005724 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 59922005725 DNA binding residues [nucleotide binding] 59922005726 dimerization interface [polypeptide binding]; other site 59922005727 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 59922005728 putative active site [active] 59922005729 putative metal binding residues [ion binding]; other site 59922005730 signature motif; other site 59922005731 putative dimer interface [polypeptide binding]; other site 59922005732 putative phosphate binding site [ion binding]; other site 59922005733 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02645 59922005734 ATP-NAD kinase; Region: NAD_kinase; pfam01513 59922005735 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 59922005736 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 59922005737 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 59922005738 NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213 59922005739 NADH-plastoquinone oxidoreductase subunit I protein; Region: ndhI; TIGR00403 59922005740 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 59922005741 NADH dehydrogenase; Region: NADHdh; cl00469 59922005742 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 59922005743 citrate synthase; Provisional; Region: PRK14036 59922005744 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 59922005745 oxalacetate binding site [chemical binding]; other site 59922005746 citrylCoA binding site [chemical binding]; other site 59922005747 coenzyme A binding site [chemical binding]; other site 59922005748 catalytic triad [active] 59922005749 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 59922005750 catalytic core [active] 59922005751 Protein of unknown function (DUF3352); Region: DUF3352; pfam11832 59922005752 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 59922005753 Transposase IS200 like; Region: Y1_Tnp; pfam01797 59922005754 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 59922005755 HprK-related kinase A; Region: HprK_rel_A; TIGR04352 59922005756 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 59922005757 DNA packaging protein UL32; Provisional; Region: PHA03233 59922005758 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 59922005759 Transposase IS200 like; Region: Y1_Tnp; pfam01797 59922005760 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 59922005761 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 59922005762 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 59922005763 pyridoxal 5'-phosphate binding site [chemical binding]; other site 59922005764 catalytic residue [active] 59922005765 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 59922005766 putative rRNA binding site [nucleotide binding]; other site 59922005767 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 59922005768 ligand-binding site [chemical binding]; other site 59922005769 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 59922005770 Domain of unknown function DUF20; Region: UPF0118; pfam01594 59922005771 AIR carboxylase; Region: AIRC; pfam00731 59922005772 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 59922005773 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 59922005774 active site 59922005775 Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580 59922005776 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 59922005777 Magnesium-protoporphyrin IX methyltransferase C-terminus; Region: Mg-por_mtran_C; pfam07109 59922005778 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 59922005779 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 59922005780 active site 59922005781 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 59922005782 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 59922005783 active site 59922005784 phosphorylation site [posttranslational modification] 59922005785 intermolecular recognition site; other site 59922005786 dimerization interface [polypeptide binding]; other site 59922005787 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 59922005788 DNA binding residues [nucleotide binding] 59922005789 dimerization interface [polypeptide binding]; other site 59922005790 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 59922005791 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 59922005792 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 59922005793 catalytic residue [active] 59922005794 MraW methylase family; Region: Methyltransf_5; cl17771 59922005795 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 59922005796 NAD(P)H-quinone oxidoreductase subunit H; Validated; Region: PRK07415 59922005797 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 59922005798 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 59922005799 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 59922005800 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 59922005801 active site 59922005802 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 59922005803 active site 59922005804 CoA binding site [chemical binding]; other site 59922005805 AMP binding site [chemical binding]; other site 59922005806 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 59922005807 o-succinylbenzoate synthase; Region: menC_gamma/gm+; TIGR01927 59922005808 active site 59922005809 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK07419 59922005810 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 59922005811 chorismate binding enzyme; Region: Chorismate_bind; cl10555 59922005812 glutathione synthetase; Provisional; Region: PRK05246 59922005813 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 59922005814 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 59922005815 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 59922005816 GSH binding site [chemical binding]; other site 59922005817 catalytic residues [active] 59922005818 This domain is found in peptide chain release factors; Region: PCRF; smart00937 59922005819 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 59922005820 RF-1 domain; Region: RF-1; pfam00472 59922005821 Protein of unknown function (DUF3285); Region: DUF3285; pfam11688 59922005822 probable rRNA maturation factor YbeY; Region: TIGR00043 59922005823 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 59922005824 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 59922005825 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 59922005826 glutamine binding [chemical binding]; other site 59922005827 catalytic triad [active] 59922005828 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 59922005829 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 59922005830 nif11-like leader peptide domain; Region: ocin_TIGR03798 59922005831 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 59922005832 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 59922005833 pyridoxal 5'-phosphate binding site [chemical binding]; other site 59922005834 homodimer interface [polypeptide binding]; other site 59922005835 catalytic residue [active] 59922005836 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 59922005837 arginine-tRNA ligase; Region: PLN02286 59922005838 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 59922005839 active site 59922005840 HIGH motif; other site 59922005841 KMSK motif region; other site 59922005842 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 59922005843 tRNA binding surface [nucleotide binding]; other site 59922005844 anticodon binding site; other site 59922005845 Transposase IS200 like; Region: Y1_Tnp; cl00848 59922005846 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 59922005847 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 59922005848 nif11-like leader peptide domain; Region: ocin_TIGR03798 59922005849 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 59922005850 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 59922005851 dimerization interface [polypeptide binding]; other site 59922005852 active site 59922005853 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 59922005854 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 59922005855 trmE is a tRNA modification GTPase; Region: trmE; cd04164 59922005856 G1 box; other site 59922005857 GTP/Mg2+ binding site [chemical binding]; other site 59922005858 Switch I region; other site 59922005859 G2 box; other site 59922005860 Switch II region; other site 59922005861 G3 box; other site 59922005862 G4 box; other site 59922005863 G5 box; other site 59922005864 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 59922005865 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 59922005866 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 59922005867 Mechanosensitive ion channel; Region: MS_channel; pfam00924 59922005868 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 59922005869 Rubredoxin; Region: Rubredoxin; pfam00301 59922005870 iron binding site [ion binding]; other site 59922005871 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 59922005872 ABC1 family; Region: ABC1; cl17513 59922005873 ABC1 family; Region: ABC1; cl17513 59922005874 enolase; Provisional; Region: eno; PRK00077 59922005875 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 59922005876 dimer interface [polypeptide binding]; other site 59922005877 metal binding site [ion binding]; metal-binding site 59922005878 substrate binding pocket [chemical binding]; other site 59922005879 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 59922005880 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 59922005881 dimer interface [polypeptide binding]; other site 59922005882 active site 59922005883 metal binding site [ion binding]; metal-binding site 59922005884 glutathione binding site [chemical binding]; other site 59922005885 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 59922005886 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 59922005887 Walker A motif; other site 59922005888 ATP binding site [chemical binding]; other site 59922005889 Walker B motif; other site 59922005890 arginine finger; other site 59922005891 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 59922005892 Walker A motif; other site 59922005893 ATP binding site [chemical binding]; other site 59922005894 Walker B motif; other site 59922005895 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 59922005896 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 59922005897 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 59922005898 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 59922005899 putative homodimer interface [polypeptide binding]; other site 59922005900 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 59922005901 heterodimer interface [polypeptide binding]; other site 59922005902 homodimer interface [polypeptide binding]; other site 59922005903 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 59922005904 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 59922005905 23S rRNA interface [nucleotide binding]; other site 59922005906 L7/L12 interface [polypeptide binding]; other site 59922005907 putative thiostrepton binding site; other site 59922005908 L25 interface [polypeptide binding]; other site 59922005909 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 59922005910 mRNA/rRNA interface [nucleotide binding]; other site 59922005911 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 59922005912 23S rRNA interface [nucleotide binding]; other site 59922005913 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 59922005914 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 59922005915 core dimer interface [polypeptide binding]; other site 59922005916 peripheral dimer interface [polypeptide binding]; other site 59922005917 L10 interface [polypeptide binding]; other site 59922005918 L11 interface [polypeptide binding]; other site 59922005919 putative EF-Tu interaction site [polypeptide binding]; other site 59922005920 putative EF-G interaction site [polypeptide binding]; other site 59922005921 Protein of unknown function (DUF3747); Region: DUF3747; pfam12565 59922005922 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 59922005923 RNA/DNA hybrid binding site [nucleotide binding]; other site 59922005924 active site 59922005925 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 59922005926 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 59922005927 quinone interaction residues [chemical binding]; other site 59922005928 active site 59922005929 catalytic residues [active] 59922005930 FMN binding site [chemical binding]; other site 59922005931 substrate binding site [chemical binding]; other site 59922005932 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 59922005933 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 59922005934 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 59922005935 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 59922005936 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 59922005937 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922005938 TPR repeat; Region: TPR_11; pfam13414 59922005939 binding surface 59922005940 TPR motif; other site 59922005941 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 59922005942 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 59922005943 pyridoxal 5'-phosphate binding site [chemical binding]; other site 59922005944 homodimer interface [polypeptide binding]; other site 59922005945 catalytic residue [active] 59922005946 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 59922005947 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 59922005948 active site 59922005949 homodimer interface [polypeptide binding]; other site 59922005950 Protein of unknown function (DUF938); Region: DUF938; pfam06080 59922005951 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 59922005952 GST_N family, Omega-like subfamily; composed of uncharacterized proteins with similarity to class Omega GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_Omega_like; cd03060 59922005953 putative GSH binding site (G-site) [chemical binding]; other site 59922005954 active site cysteine [active] 59922005955 putative C-terminal domain interface [polypeptide binding]; other site 59922005956 putative dimer interface [polypeptide binding]; other site 59922005957 C-terminal, alpha helical domain of an unknown subfamily 5 of Glutathione S-transferases; Region: GST_C_5; cd03196 59922005958 putative N-terminal domain interface [polypeptide binding]; other site 59922005959 putative substrate binding pocket (H-site) [chemical binding]; other site 59922005960 Protein of unknown function (DUF952); Region: DUF952; pfam06108 59922005961 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 59922005962 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 59922005963 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 59922005964 Phosphoglycerate kinase; Region: PGK; pfam00162 59922005965 substrate binding site [chemical binding]; other site 59922005966 hinge regions; other site 59922005967 ADP binding site [chemical binding]; other site 59922005968 catalytic site [active] 59922005969 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 59922005970 Ligand Binding Site [chemical binding]; other site 59922005971 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 59922005972 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 59922005973 GTP/Mg2+ binding site [chemical binding]; other site 59922005974 G4 box; other site 59922005975 G5 box; other site 59922005976 G1 box; other site 59922005977 Switch I region; other site 59922005978 G2 box; other site 59922005979 G3 box; other site 59922005980 Switch II region; other site 59922005981 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 59922005982 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 59922005983 RNA binding surface [nucleotide binding]; other site 59922005984 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 59922005985 active site 59922005986 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 59922005987 Sulfatase; Region: Sulfatase; cl17466 59922005988 Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862 59922005989 CBD_II domain; Region: CBD_II; smart00637 59922005990 CBD_II domain; Region: CBD_II; smart00637 59922005991 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 59922005992 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 59922005993 Walker A/P-loop; other site 59922005994 ATP binding site [chemical binding]; other site 59922005995 Q-loop/lid; other site 59922005996 ABC transporter signature motif; other site 59922005997 Walker B; other site 59922005998 D-loop; other site 59922005999 H-loop/switch region; other site 59922006000 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 59922006001 Walker A/P-loop; other site 59922006002 ATP binding site [chemical binding]; other site 59922006003 Q-loop/lid; other site 59922006004 ABC transporter signature motif; other site 59922006005 Walker B; other site 59922006006 D-loop; other site 59922006007 H-loop/switch region; other site 59922006008 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 59922006009 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 59922006010 Zn2+ binding site [ion binding]; other site 59922006011 Mg2+ binding site [ion binding]; other site 59922006012 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 59922006013 synthetase active site [active] 59922006014 NTP binding site [chemical binding]; other site 59922006015 metal binding site [ion binding]; metal-binding site 59922006016 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 59922006017 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 59922006018 hypothetical protein; Validated; Region: PRK00029 59922006019 Uncharacterized conserved protein [Function unknown]; Region: COG0397 59922006020 nif11-like leader peptide domain; Region: ocin_TIGR03798 59922006021 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 59922006022 heterotetramer interface [polypeptide binding]; other site 59922006023 active site pocket [active] 59922006024 cleavage site 59922006025 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 59922006026 dephospho-CoA kinase; Region: TIGR00152 59922006027 CoA-binding site [chemical binding]; other site 59922006028 ATP-binding [chemical binding]; other site 59922006029 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 59922006030 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 59922006031 Ligand binding site; other site 59922006032 Putative Catalytic site; other site 59922006033 DXD motif; other site 59922006034 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 59922006035 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 59922006036 GatB domain; Region: GatB_Yqey; smart00845 59922006037 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 59922006038 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 59922006039 active site 59922006040 multimer interface [polypeptide binding]; other site 59922006041 arginine decarboxylase; Provisional; Region: PRK05354 59922006042 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 59922006043 dimer interface [polypeptide binding]; other site 59922006044 active site 59922006045 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 59922006046 catalytic residues [active] 59922006047 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 59922006048 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 59922006049 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 59922006050 ligand binding site [chemical binding]; other site 59922006051 flexible hinge region; other site 59922006052 putative switch regulator; other site 59922006053 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 59922006054 non-specific DNA interactions [nucleotide binding]; other site 59922006055 DNA binding site [nucleotide binding] 59922006056 sequence specific DNA binding site [nucleotide binding]; other site 59922006057 putative cAMP binding site [chemical binding]; other site 59922006058 CHASE2 domain; Region: CHASE2; pfam05226 59922006059 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 59922006060 cyclase homology domain; Region: CHD; cd07302 59922006061 nucleotidyl binding site; other site 59922006062 metal binding site [ion binding]; metal-binding site 59922006063 dimer interface [polypeptide binding]; other site 59922006064 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 59922006065 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 59922006066 ligand binding site [chemical binding]; other site 59922006067 flexible hinge region; other site 59922006068 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 59922006069 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 59922006070 active site 59922006071 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 59922006072 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 59922006073 motif 1; other site 59922006074 active site 59922006075 motif 2; other site 59922006076 motif 3; other site 59922006077 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 59922006078 SNF2 Helicase protein; Region: DUF3670; pfam12419 59922006079 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 59922006080 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 59922006081 ATP binding site [chemical binding]; other site 59922006082 putative Mg++ binding site [ion binding]; other site 59922006083 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 59922006084 nucleotide binding region [chemical binding]; other site 59922006085 ATP-binding site [chemical binding]; other site 59922006086 Uncharacterized conserved protein [Function unknown]; Region: COG4279 59922006087 MEKHLA domain; Region: MEKHLA; pfam08670 59922006088 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 59922006089 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 59922006090 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 59922006091 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 59922006092 DctM-like transporters; Region: DctM; pfam06808 59922006093 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 59922006094 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 59922006095 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 59922006096 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 59922006097 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 59922006098 DNA binding site [nucleotide binding] 59922006099 TPR repeat; Region: TPR_11; pfam13414 59922006100 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922006101 binding surface 59922006102 TPR motif; other site 59922006103 TPR repeat; Region: TPR_11; pfam13414 59922006104 TPR repeat; Region: TPR_11; pfam13414 59922006105 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922006106 binding surface 59922006107 TPR motif; other site 59922006108 TPR repeat; Region: TPR_11; pfam13414 59922006109 TPR repeat; Region: TPR_11; pfam13414 59922006110 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922006111 binding surface 59922006112 TPR motif; other site 59922006113 TPR repeat; Region: TPR_11; pfam13414 59922006114 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922006115 binding surface 59922006116 TPR motif; other site 59922006117 TPR repeat; Region: TPR_11; pfam13414 59922006118 TPR repeat; Region: TPR_11; pfam13414 59922006119 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922006120 binding surface 59922006121 TPR motif; other site 59922006122 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 59922006123 active site 59922006124 catalytic residues [active] 59922006125 DNA binding site [nucleotide binding] 59922006126 Int/Topo IB signature motif; other site 59922006127 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 59922006128 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 59922006129 TPR repeat; Region: TPR_11; pfam13414 59922006130 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922006131 binding surface 59922006132 TPR motif; other site 59922006133 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 59922006134 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922006135 binding surface 59922006136 TPR motif; other site 59922006137 Tetratricopeptide repeat; Region: TPR_1; pfam00515 59922006138 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922006139 binding surface 59922006140 TPR motif; other site 59922006141 TPR repeat; Region: TPR_11; pfam13414 59922006142 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 59922006143 DNA binding site [nucleotide binding] 59922006144 active site 59922006145 Int/Topo IB signature motif; other site 59922006146 catalytic residues [active] 59922006147 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 59922006148 FHA domain; Region: FHA; pfam00498 59922006149 phosphopeptide binding site; other site 59922006150 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 59922006151 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 59922006152 phosphopeptide binding site; other site 59922006153 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 59922006154 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 59922006155 Walker A/P-loop; other site 59922006156 ATP binding site [chemical binding]; other site 59922006157 Q-loop/lid; other site 59922006158 ABC transporter signature motif; other site 59922006159 Walker B; other site 59922006160 D-loop; other site 59922006161 H-loop/switch region; other site 59922006162 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 59922006163 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 59922006164 Circadian oscillating protein COP23; Region: COP23; pfam14218 59922006165 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 59922006166 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 59922006167 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922006168 binding surface 59922006169 TPR motif; other site 59922006170 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 59922006171 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922006172 binding surface 59922006173 TPR motif; other site 59922006174 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922006175 binding surface 59922006176 TPR motif; other site 59922006177 Protein phosphatase 2C; Region: PP2C_2; pfam13672 59922006178 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 59922006179 metal ion-dependent adhesion site (MIDAS); other site 59922006180 Catalytic domain of Protein Kinases; Region: PKc; cd00180 59922006181 substrate binding site [chemical binding]; other site 59922006182 activation loop (A-loop); other site 59922006183 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 59922006184 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 59922006185 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 59922006186 binding surface 59922006187 TPR motif; other site 59922006188 Tetratricopeptide repeat; Region: TPR_1; pfam00515 59922006189 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922006190 binding surface 59922006191 TPR motif; other site 59922006192 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922006193 binding surface 59922006194 TPR motif; other site 59922006195 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922006196 TPR repeat; Region: TPR_11; pfam13414 59922006197 binding surface 59922006198 TPR motif; other site 59922006199 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922006200 TPR motif; other site 59922006201 TPR repeat; Region: TPR_11; pfam13414 59922006202 binding surface 59922006203 TPR repeat; Region: TPR_11; pfam13414 59922006204 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922006205 binding surface 59922006206 TPR motif; other site 59922006207 TPR repeat; Region: TPR_11; pfam13414 59922006208 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922006209 binding surface 59922006210 TPR motif; other site 59922006211 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 59922006212 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 59922006213 Tetratricopeptide repeat; Region: TPR_1; pfam00515 59922006214 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922006215 binding surface 59922006216 TPR motif; other site 59922006217 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922006218 binding surface 59922006219 TPR motif; other site 59922006220 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922006221 binding surface 59922006222 TPR motif; other site 59922006223 TPR repeat; Region: TPR_11; pfam13414 59922006224 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 59922006225 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922006226 binding surface 59922006227 TPR motif; other site 59922006228 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922006229 binding surface 59922006230 TPR motif; other site 59922006231 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 59922006232 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 59922006233 TPR repeat; Region: TPR_11; pfam13414 59922006234 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922006235 binding surface 59922006236 TPR motif; other site 59922006237 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 59922006238 Tetratricopeptide repeat; Region: TPR_1; pfam00515 59922006239 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922006240 binding surface 59922006241 TPR motif; other site 59922006242 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59922006243 binding surface 59922006244 TPR motif; other site 59922006245 TPR repeat; Region: TPR_11; pfam13414 59922006246 multiple promoter invertase; Provisional; Region: mpi; PRK13413 59922006247 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 59922006248 catalytic residues [active] 59922006249 catalytic nucleophile [active] 59922006250 Presynaptic Site I dimer interface [polypeptide binding]; other site 59922006251 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 59922006252 Synaptic Flat tetramer interface [polypeptide binding]; other site 59922006253 Synaptic Site I dimer interface [polypeptide binding]; other site 59922006254 DNA binding site [nucleotide binding] 59922006255 TAP C-terminal domain; Region: TAP_C; cl04338 59922006256 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 59922006257 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 59922006258 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 59922006259 Rubrerythrin [Energy production and conversion]; Region: COG1592 59922006260 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 59922006261 binuclear metal center [ion binding]; other site 59922006262 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 59922006263 iron binding site [ion binding]; other site 59922006264 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 59922006265 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 59922006266 glycine dehydrogenase; Provisional; Region: PRK05367 59922006267 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 59922006268 tetramer interface [polypeptide binding]; other site 59922006269 pyridoxal 5'-phosphate binding site [chemical binding]; other site 59922006270 catalytic residue [active] 59922006271 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 59922006272 tetramer interface [polypeptide binding]; other site 59922006273 pyridoxal 5'-phosphate binding site [chemical binding]; other site 59922006274 catalytic residue [active] 59922006275 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 59922006276 lipoyl attachment site [posttranslational modification]; other site 59922006277 Aluminium resistance protein; Region: Alum_res; pfam06838 59922006278 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 59922006279 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 59922006280 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 59922006281 Fatty acid desaturase; Region: FA_desaturase; pfam00487 59922006282 Di-iron ligands [ion binding]; other site 59922006283 Fatty acid desaturase; Region: FA_desaturase; pfam00487 59922006284 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 59922006285 Di-iron ligands [ion binding]; other site 59922006286 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 59922006287 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 59922006288 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 59922006289 replicative DNA helicase; Region: DnaB; TIGR00665 59922006290 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 59922006291 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 59922006292 Walker A motif; other site 59922006293 ATP binding site [chemical binding]; other site 59922006294 Walker B motif; other site 59922006295 DNA binding loops [nucleotide binding] 59922006296 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 59922006297 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 59922006298 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 59922006299 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 59922006300 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 59922006301 Protein of unknown function (DUF98); Region: DUF98; pfam01947 59922006302 SprT-like family; Region: SprT-like; pfam10263 59922006303 SprT homologues; Region: SprT; cl01182 59922006304 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 59922006305 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 59922006306 nucleotide binding pocket [chemical binding]; other site 59922006307 K-X-D-G motif; other site 59922006308 catalytic site [active] 59922006309 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 59922006310 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 59922006311 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 59922006312 Dimer interface [polypeptide binding]; other site 59922006313 BRCT sequence motif; other site 59922006314 Uncharacterized conserved protein [Function unknown]; Region: COG0398 59922006315 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 59922006316 Berberine and berberine like; Region: BBE; pfam08031 59922006317 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 59922006318 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 59922006319 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 59922006320 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 59922006321 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 59922006322 Walker A/P-loop; other site 59922006323 ATP binding site [chemical binding]; other site 59922006324 Q-loop/lid; other site 59922006325 ABC transporter signature motif; other site 59922006326 Walker B; other site 59922006327 D-loop; other site 59922006328 H-loop/switch region; other site 59922006329 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 59922006330 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 59922006331 active site 59922006332 HIGH motif; other site 59922006333 nucleotide binding site [chemical binding]; other site 59922006334 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 59922006335 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 59922006336 active site 59922006337 KMSKS motif; other site 59922006338 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 59922006339 tRNA binding surface [nucleotide binding]; other site 59922006340 anticodon binding site; other site 59922006341 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 59922006342 SpoVR like protein; Region: SpoVR; pfam04293 59922006343 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 59922006344 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 59922006345 catalytic loop [active] 59922006346 iron binding site [ion binding]; other site 59922006347 magnesium-protoporphyrin IX monomethyl ester cyclase; Provisional; Region: PRK13654 59922006348 dinuclear metal binding motif [ion binding]; other site 59922006349 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 59922006350 dimerization interface [polypeptide binding]; other site 59922006351 putative DNA binding site [nucleotide binding]; other site 59922006352 putative Zn2+ binding site [ion binding]; other site 59922006353 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 59922006354 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 59922006355 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 59922006356 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 59922006357 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 59922006358 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 59922006359 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 59922006360 Walker A motif; other site 59922006361 ATP binding site [chemical binding]; other site 59922006362 Walker B motif; other site 59922006363 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 59922006364 4Fe-4S binding domain; Region: Fer4_5; pfam12801 59922006365 4Fe-4S binding domain; Region: Fer4_5; pfam12801 59922006366 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 59922006367 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 59922006368 ABC-ATPase subunit interface; other site 59922006369 dimer interface [polypeptide binding]; other site 59922006370 putative PBP binding regions; other site 59922006371 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 59922006372 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 59922006373 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 59922006374 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 59922006375 intersubunit interface [polypeptide binding]; other site 59922006376 TIGR03943 family protein; Region: TIGR03943 59922006377 Predicted permease; Region: DUF318; cl17795 59922006378 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 59922006379 metal binding site 2 [ion binding]; metal-binding site 59922006380 putative DNA binding helix; other site 59922006381 metal binding site 1 [ion binding]; metal-binding site 59922006382 dimer interface [polypeptide binding]; other site 59922006383 structural Zn2+ binding site [ion binding]; other site 59922006384 Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; pfam09988 59922006385 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 59922006386 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 59922006387 homodimer interface [polypeptide binding]; other site 59922006388 metal binding site [ion binding]; metal-binding site 59922006389 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 59922006390 homodimer interface [polypeptide binding]; other site 59922006391 active site 59922006392 putative chemical substrate binding site [chemical binding]; other site 59922006393 metal binding site [ion binding]; metal-binding site 59922006394 hypothetical protein; Provisional; Region: PRK09256 59922006395 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 59922006396 active site 59922006397 metal-binding site 59922006398 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 59922006399 catalytic triad [active] 59922006400 hypothetical protein; Provisional; Region: PRK05849 59922006401 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 59922006402 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 59922006403 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 59922006404 S-adenosylmethionine binding site [chemical binding]; other site 59922006405 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 59922006406 hypothetical protein; Provisional; Region: PRK09256 59922006407 spermidine synthase; Provisional; Region: PRK00811 59922006408 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 59922006409 S-adenosylmethionine binding site [chemical binding]; other site 59922006410 agmatinase; Region: agmatinase; TIGR01230 59922006411 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 59922006412 putative active site [active] 59922006413 Mn binding site [ion binding]; other site 59922006414 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 59922006415 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 59922006416 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 59922006417 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 59922006418 dimer interface [polypeptide binding]; other site 59922006419 anticodon binding site; other site 59922006420 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 59922006421 homodimer interface [polypeptide binding]; other site 59922006422 motif 1; other site 59922006423 active site 59922006424 motif 2; other site 59922006425 GAD domain; Region: GAD; pfam02938 59922006426 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 59922006427 active site 59922006428 motif 3; other site 59922006429 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 59922006430 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 59922006431 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 59922006432 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 59922006433 DNA binding residues [nucleotide binding] 59922006434 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 59922006435 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 59922006436 dimerization interface [polypeptide binding]; other site 59922006437 DPS ferroxidase diiron center [ion binding]; other site 59922006438 ion pore; other site 59922006439 CTP synthetase; Validated; Region: pyrG; PRK05380 59922006440 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 59922006441 Catalytic site [active] 59922006442 active site 59922006443 UTP binding site [chemical binding]; other site 59922006444 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 59922006445 active site 59922006446 putative oxyanion hole; other site 59922006447 catalytic triad [active] 59922006448 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 59922006449 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 59922006450 Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cl00178 59922006451 Transposase IS200 like; Region: Y1_Tnp; pfam01797 59922006452 Nitrogen fixation protein of unknown function; Region: Nif11; cl06756 59922006453 Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862 59922006454 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 59922006455 Ligand Binding Site [chemical binding]; other site 59922006456 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 59922006457 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 59922006458 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 59922006459 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 59922006460 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 59922006461 pyridoxal 5'-phosphate binding site [chemical binding]; other site 59922006462 catalytic residue [active] 59922006463 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 59922006464 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 59922006465 Walker A/P-loop; other site 59922006466 ATP binding site [chemical binding]; other site 59922006467 Q-loop/lid; other site 59922006468 ABC transporter signature motif; other site 59922006469 Walker B; other site 59922006470 D-loop; other site 59922006471 H-loop/switch region; other site 59922006472 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 59922006473 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 59922006474 Walker A/P-loop; other site 59922006475 ATP binding site [chemical binding]; other site 59922006476 Q-loop/lid; other site 59922006477 ABC transporter signature motif; other site 59922006478 Walker B; other site 59922006479 D-loop; other site 59922006480 H-loop/switch region; other site 59922006481 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 59922006482 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 59922006483 TM-ABC transporter signature motif; other site 59922006484 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 59922006485 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 59922006486 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 59922006487 TM-ABC transporter signature motif; other site 59922006488 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 59922006489 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 59922006490 putative ligand binding site [chemical binding]; other site 59922006491 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 59922006492 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 59922006493 UreF; Region: UreF; pfam01730 59922006494 Urease accessory protein UreE [Posttranslational modification, protein turnover, chaperones]; Region: UreE; COG2371 59922006495 UreE urease accessory protein, N-terminal domain; Region: UreE_N; smart00988 59922006496 UreE urease accessory protein, C-terminal domain; Region: UreE_C; pfam05194 59922006497 UreD urease accessory protein; Region: UreD; pfam01774 59922006498 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 59922006499 alpha-gamma subunit interface [polypeptide binding]; other site 59922006500 beta-gamma subunit interface [polypeptide binding]; other site 59922006501 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 59922006502 alpha-beta subunit interface [polypeptide binding]; other site 59922006503 urease subunit alpha; Reviewed; Region: ureC; PRK13207 59922006504 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 59922006505 subunit interactions [polypeptide binding]; other site 59922006506 active site 59922006507 flap region; other site 59922006508 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 59922006509 active site 59922006510 SAM binding site [chemical binding]; other site 59922006511 homodimer interface [polypeptide binding]; other site 59922006512 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 59922006513 putative active site [active] 59922006514 ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566 59922006515 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 59922006516 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 59922006517 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 59922006518 hypothetical protein; Provisional; Region: PRK07394 59922006519 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 59922006520 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 59922006521 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 59922006522 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 59922006523 Major Facilitator Superfamily; Region: MFS_1; pfam07690 59922006524 putative substrate translocation pore; other site 59922006525 polyphosphate kinase; Provisional; Region: PRK05443 59922006526 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 59922006527 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 59922006528 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 59922006529 putative domain interface [polypeptide binding]; other site 59922006530 putative active site [active] 59922006531 catalytic site [active] 59922006532 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 59922006533 putative domain interface [polypeptide binding]; other site 59922006534 putative active site [active] 59922006535 catalytic site [active] 59922006536 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 59922006537 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 59922006538 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 59922006539 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 59922006540 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 59922006541 DNA binding residues [nucleotide binding] 59922006542 Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170 59922006543 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 59922006544 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 59922006545 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 59922006546 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 59922006547 substrate binding site [chemical binding]; other site 59922006548 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 59922006549 substrate binding site [chemical binding]; other site 59922006550 ligand binding site [chemical binding]; other site 59922006551 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 59922006552 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 59922006553 Cl- selectivity filter; other site 59922006554 Cl- binding residues [ion binding]; other site 59922006555 pore gating glutamate residue; other site 59922006556 dimer interface [polypeptide binding]; other site 59922006557 H+/Cl- coupling transport residue; other site 59922006558 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 59922006559 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 59922006560 B12 binding site [chemical binding]; other site 59922006561 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 59922006562 FeS/SAM binding site; other site 59922006563 O-Antigen ligase; Region: Wzy_C; pfam04932 59922006564 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 59922006565 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 59922006566 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 59922006567 putative active site [active] 59922006568 putative substrate binding site [chemical binding]; other site 59922006569 putative cosubstrate binding site; other site 59922006570 catalytic site [active] 59922006571 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 59922006572 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 59922006573 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 59922006574 nucleotide binding site [chemical binding]; other site 59922006575 NEF interaction site [polypeptide binding]; other site 59922006576 SBD interface [polypeptide binding]; other site 59922006577 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 59922006578 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 59922006579 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 59922006580 shikimate binding site; other site 59922006581 NAD(P) binding site [chemical binding]; other site 59922006582 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 59922006583 argininosuccinate synthase; Provisional; Region: PRK13820 59922006584 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 59922006585 ANP binding site [chemical binding]; other site 59922006586 Substrate Binding Site II [chemical binding]; other site 59922006587 Substrate Binding Site I [chemical binding]; other site 59922006588 Protein of unknown function (DUF3134); Region: DUF3134; pfam11332 59922006589 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 59922006590 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 59922006591 Mg++ binding site [ion binding]; other site 59922006592 putative catalytic motif [active] 59922006593 putative substrate binding site [chemical binding]; other site 59922006594 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 59922006595 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 59922006596 ATP-grasp domain; Region: ATP-grasp; pfam02222 59922006597 sucrose-phosphate synthase, putative, glycosyltransferase domain; Region: sucr_P_syn_N; TIGR02472 59922006598 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 59922006599 putative ADP-binding pocket [chemical binding]; other site 59922006600 sucrose phosphate synthase, sucrose phosphatase-like domain, bacterial; Region: sucr_syn_bact_C; TIGR02471 59922006601 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 59922006602 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 59922006603 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 59922006604 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 59922006605 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 59922006606 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 59922006607 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 59922006608 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 59922006609 Walker A/P-loop; other site 59922006610 ATP binding site [chemical binding]; other site 59922006611 Q-loop/lid; other site 59922006612 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 59922006613 ABC transporter signature motif; other site 59922006614 Walker B; other site 59922006615 D-loop; other site 59922006616 H-loop/switch region; other site 59922006617 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 59922006618 ABC1 family; Region: ABC1; cl17513 59922006619 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 59922006620 threonine synthase; Reviewed; Region: PRK06721 59922006621 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 59922006622 homodimer interface [polypeptide binding]; other site 59922006623 pyridoxal 5'-phosphate binding site [chemical binding]; other site 59922006624 catalytic residue [active]