-- dump date 20140620_000242 -- class Genbank::misc_feature -- table misc_feature_note -- id note 74546000001 DNA polymerase III subunit beta; Validated; Region: PRK05643 74546000002 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 74546000003 putative DNA binding surface [nucleotide binding]; other site 74546000004 dimer interface [polypeptide binding]; other site 74546000005 beta-clamp/clamp loader binding surface; other site 74546000006 beta-clamp/translesion DNA polymerase binding surface; other site 74546000007 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 74546000008 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 74546000009 dimerization interface [polypeptide binding]; other site 74546000010 ATP binding site [chemical binding]; other site 74546000011 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 74546000012 dimerization interface [polypeptide binding]; other site 74546000013 ATP binding site [chemical binding]; other site 74546000014 amidophosphoribosyltransferase; Provisional; Region: PRK09246 74546000015 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 74546000016 active site 74546000017 tetramer interface [polypeptide binding]; other site 74546000018 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 74546000019 active site 74546000020 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit [DNA replication, recombination, and repair]; Region: GyrA; COG0188 74546000021 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 74546000022 CAP-like domain; other site 74546000023 active site 74546000024 primary dimer interface [polypeptide binding]; other site 74546000025 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 74546000026 binding surface 74546000027 TPR motif; other site 74546000028 Tetratricopeptide repeat; Region: TPR_16; pfam13432 74546000029 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 74546000030 binding surface 74546000031 TPR motif; other site 74546000032 TPR repeat; Region: TPR_11; pfam13414 74546000033 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 74546000034 binding surface 74546000035 TPR repeat; Region: TPR_11; pfam13414 74546000036 TPR motif; other site 74546000037 epoxyqueuosine reductase; Region: TIGR00276 74546000038 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 74546000039 Uncharacterized conserved protein [Function unknown]; Region: COG2928 74546000040 transcription antitermination protein NusB; Provisional; Region: nusB; PRK09634 74546000041 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 74546000042 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 74546000043 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 74546000044 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 74546000045 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 74546000046 argininosuccinate lyase; Provisional; Region: PRK00855 74546000047 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 74546000048 active sites [active] 74546000049 tetramer interface [polypeptide binding]; other site 74546000050 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 74546000051 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 74546000052 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 74546000053 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 74546000054 FMN binding site [chemical binding]; other site 74546000055 active site 74546000056 catalytic residues [active] 74546000057 substrate binding site [chemical binding]; other site 74546000058 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 74546000059 SelR domain; Region: SelR; pfam01641 74546000060 GrpE; Region: GrpE; pfam01025 74546000061 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 74546000062 dimer interface [polypeptide binding]; other site 74546000063 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 74546000064 chaperone protein DnaJ; Provisional; Region: PRK14293 74546000065 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 74546000066 HSP70 interaction site [polypeptide binding]; other site 74546000067 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 74546000068 substrate binding site [polypeptide binding]; other site 74546000069 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 74546000070 Zn binding sites [ion binding]; other site 74546000071 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 74546000072 dimer interface [polypeptide binding]; other site 74546000073 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 74546000074 CPxP motif; other site 74546000075 Predicted GTPases [General function prediction only]; Region: COG1162 74546000076 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 74546000077 GTPase/Zn-binding domain interface [polypeptide binding]; other site 74546000078 GTP/Mg2+ binding site [chemical binding]; other site 74546000079 G4 box; other site 74546000080 G5 box; other site 74546000081 G1 box; other site 74546000082 Switch I region; other site 74546000083 G2 box; other site 74546000084 G3 box; other site 74546000085 Switch II region; other site 74546000086 hypothetical protein; Validated; Region: PRK00153 74546000087 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 74546000088 FAD binding domain; Region: FAD_binding_4; pfam01565 74546000089 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 74546000090 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 74546000091 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 74546000092 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 74546000093 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK07403 74546000094 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 74546000095 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 74546000096 thiamine monophosphate kinase; Provisional; Region: PRK05731 74546000097 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 74546000098 ATP binding site [chemical binding]; other site 74546000099 dimerization interface [polypeptide binding]; other site 74546000100 Borrelia burgdorferi protein of unknown function (DUF787); Region: DUF787; pfam05619 74546000101 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 74546000102 active site 74546000103 elongation factor P; Validated; Region: PRK00529 74546000104 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 74546000105 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 74546000106 RNA binding site [nucleotide binding]; other site 74546000107 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 74546000108 RNA binding site [nucleotide binding]; other site 74546000109 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 74546000110 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 74546000111 carboxyltransferase (CT) interaction site; other site 74546000112 biotinylation site [posttranslational modification]; other site 74546000113 4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK02746 74546000114 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 74546000115 NADH(P)-binding; Region: NAD_binding_10; pfam13460 74546000116 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 74546000117 NAD(P) binding site [chemical binding]; other site 74546000118 active site 74546000119 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 74546000120 active site 74546000121 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 74546000122 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 74546000123 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 74546000124 homodimer interface [polypeptide binding]; other site 74546000125 pyridoxal 5'-phosphate binding site [chemical binding]; other site 74546000126 catalytic residue [active] 74546000127 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 74546000128 GMP synthase; Reviewed; Region: guaA; PRK00074 74546000129 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 74546000130 AMP/PPi binding site [chemical binding]; other site 74546000131 candidate oxyanion hole; other site 74546000132 catalytic triad [active] 74546000133 potential glutamine specificity residues [chemical binding]; other site 74546000134 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 74546000135 ATP Binding subdomain [chemical binding]; other site 74546000136 Ligand Binding sites [chemical binding]; other site 74546000137 Dimerization subdomain; other site 74546000138 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 74546000139 binding surface 74546000140 TPR motif; other site 74546000141 TPR repeat; Region: TPR_11; pfam13414 74546000142 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 74546000143 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 74546000144 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 74546000145 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 74546000146 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 74546000147 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 74546000148 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 74546000149 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 74546000150 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 74546000151 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 74546000152 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 74546000153 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 74546000154 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 74546000155 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 74546000156 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 74546000157 motif 1; other site 74546000158 active site 74546000159 motif 2; other site 74546000160 motif 3; other site 74546000161 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 74546000162 DHHA1 domain; Region: DHHA1; pfam02272 74546000163 arginine decarboxylase; Provisional; Region: PRK05354 74546000164 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 74546000165 dimer interface [polypeptide binding]; other site 74546000166 active site 74546000167 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 74546000168 catalytic residues [active] 74546000169 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 74546000170 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 74546000171 active site 74546000172 multimer interface [polypeptide binding]; other site 74546000173 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 74546000174 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 74546000175 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 74546000176 GatB domain; Region: GatB_Yqey; smart00845 74546000177 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 74546000178 dephospho-CoA kinase; Region: TIGR00152 74546000179 CoA-binding site [chemical binding]; other site 74546000180 ATP-binding [chemical binding]; other site 74546000181 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 74546000182 heterotetramer interface [polypeptide binding]; other site 74546000183 active site pocket [active] 74546000184 cleavage site 74546000185 ParA-like protein; Provisional; Region: PHA02518 74546000186 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 74546000187 P-loop; other site 74546000188 Magnesium ion binding site [ion binding]; other site 74546000189 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 74546000190 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 74546000191 active site 74546000192 catalytic tetrad [active] 74546000193 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 74546000194 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 74546000195 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 74546000196 DNA polymerase Ligase (LigD); Region: LigD_N; pfam13298 74546000197 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 74546000198 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 74546000199 Walker A/P-loop; other site 74546000200 ATP binding site [chemical binding]; other site 74546000201 Q-loop/lid; other site 74546000202 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 74546000203 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 74546000204 ABC transporter signature motif; other site 74546000205 Walker B; other site 74546000206 D-loop; other site 74546000207 H-loop/switch region; other site 74546000208 PRC-barrel domain; Region: PRC; pfam05239 74546000209 Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763 74546000210 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 74546000211 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 74546000212 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 74546000213 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 74546000214 YGGT family; Region: YGGT; pfam02325 74546000215 Photosystem II reaction centre X protein (PsbX); Region: PsbX; cl05887 74546000216 Ycf66 protein N-terminus; Region: Ycf66_N; pfam07444 74546000217 Chlorophyll A-B binding protein; Region: Chloroa_b-bind; pfam00504 74546000218 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 74546000219 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 74546000220 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 74546000221 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 74546000222 nucleotide binding site/active site [active] 74546000223 HIT family signature motif; other site 74546000224 catalytic residue [active] 74546000225 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 74546000226 active site 74546000227 catalytic residues [active] 74546000228 metal binding site [ion binding]; metal-binding site 74546000229 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 74546000230 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 74546000231 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 74546000232 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 74546000233 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 74546000234 catalytic residue [active] 74546000235 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 74546000236 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 74546000237 sulfate ABC transporter protein; Validated; Region: ycf16; CHL00131 74546000238 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 74546000239 Walker A/P-loop; other site 74546000240 ATP binding site [chemical binding]; other site 74546000241 Q-loop/lid; other site 74546000242 ABC transporter signature motif; other site 74546000243 Walker B; other site 74546000244 D-loop; other site 74546000245 H-loop/switch region; other site 74546000246 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 74546000247 putative ABC transporter; Region: ycf24; CHL00085 74546000248 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 74546000249 phosphoglucomutase; Region: PLN02307 74546000250 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 74546000251 active site 74546000252 substrate binding site [chemical binding]; other site 74546000253 metal binding site [ion binding]; metal-binding site 74546000254 recombination factor protein RarA; Reviewed; Region: PRK13342 74546000255 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 74546000256 Walker A motif; other site 74546000257 ATP binding site [chemical binding]; other site 74546000258 Walker B motif; other site 74546000259 arginine finger; other site 74546000260 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 74546000261 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 74546000262 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 74546000263 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 74546000264 catalytic triad [active] 74546000265 Type III pantothenate kinase; Region: Pan_kinase; cl17198 74546000266 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 74546000267 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 74546000268 Active Sites [active] 74546000269 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 74546000270 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 74546000271 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 74546000272 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 74546000273 transmembrane helices; other site 74546000274 TrkA-C domain; Region: TrkA_C; pfam02080 74546000275 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 74546000276 TrkA-C domain; Region: TrkA_C; pfam02080 74546000277 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 74546000278 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 74546000279 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 74546000280 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 74546000281 TrkA-N domain; Region: TrkA_N; pfam02254 74546000282 TrkA-C domain; Region: TrkA_C; pfam02080 74546000283 Protein of unknown function (DUF1662); Region: DUF1662; pfam07878 74546000284 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 74546000285 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 74546000286 Walker A/P-loop; other site 74546000287 ATP binding site [chemical binding]; other site 74546000288 Q-loop/lid; other site 74546000289 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 74546000290 ABC transporter signature motif; other site 74546000291 Walker B; other site 74546000292 D-loop; other site 74546000293 ABC transporter; Region: ABC_tran_2; pfam12848 74546000294 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 74546000295 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 74546000296 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 74546000297 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 74546000298 protein binding site [polypeptide binding]; other site 74546000299 Protein of unknown function (DUF2973); Region: DUF2973; pfam11189 74546000300 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 74546000301 Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643 74546000302 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 74546000303 active site 74546000304 Outer membrane efflux protein; Region: OEP; pfam02321 74546000305 Outer membrane efflux protein; Region: OEP; pfam02321 74546000306 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 74546000307 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 74546000308 Protein of unknown function (DUF512); Region: DUF512; pfam04459 74546000309 Protein of unknown function (DUF3120); Region: DUF3120; pfam11318 74546000310 L-aspartate oxidase; Provisional; Region: PRK06175 74546000311 L-aspartate oxidase; Provisional; Region: PRK07395 74546000312 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 74546000313 Vitamin K epoxide reductase family in bacteria and plants; Region: VKOR_1; cd12916 74546000314 substrate binding site [chemical binding]; other site 74546000315 putative active site [active] 74546000316 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 74546000317 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 74546000318 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 74546000319 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 74546000320 FeS/SAM binding site; other site 74546000321 TRAM domain; Region: TRAM; cl01282 74546000322 Domain of unknown function (DUF4346); Region: DUF4346; pfam14251 74546000323 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 74546000324 Protein of unknown function, DUF482; Region: DUF482; pfam04339 74546000325 RibD C-terminal domain; Region: RibD_C; cl17279 74546000326 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 74546000327 active site 74546000328 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 74546000329 active site 74546000330 shikimate kinase; Reviewed; Region: aroK; PRK00131 74546000331 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 74546000332 ADP binding site [chemical binding]; other site 74546000333 magnesium binding site [ion binding]; other site 74546000334 putative shikimate binding site; other site 74546000335 Protein of unknown function (DUF3571); Region: DUF3571; pfam12095 74546000336 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 74546000337 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 74546000338 C-terminal domain interface [polypeptide binding]; other site 74546000339 GSH binding site (G-site) [chemical binding]; other site 74546000340 dimer interface [polypeptide binding]; other site 74546000341 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 74546000342 N-terminal domain interface [polypeptide binding]; other site 74546000343 Protein of unknown function (DUF751); Region: DUF751; pfam05421 74546000344 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 74546000345 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 74546000346 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 74546000347 active site 74546000348 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 74546000349 hydrophobic ligand binding site; other site 74546000350 9,9'-di-cis-zeta-carotene desaturase; Region: zeta_caro_desat; TIGR02732 74546000351 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 74546000352 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 74546000353 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370 74546000354 conserved hypothetical protein; Region: TIGR03492 74546000355 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 74546000356 TIGR01777 family protein; Region: yfcH 74546000357 putative NAD(P) binding site [chemical binding]; other site 74546000358 putative active site [active] 74546000359 Cyanobacterial and plant NDH-1 subunit O; Region: NdhO; pfam11910 74546000360 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 74546000361 HSP70 interaction site [polypeptide binding]; other site 74546000362 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 74546000363 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 74546000364 dimer interface [polypeptide binding]; other site 74546000365 pyridoxal 5'-phosphate binding site [chemical binding]; other site 74546000366 catalytic residue [active] 74546000367 hypothetical protein; Provisional; Region: PRK13683 74546000368 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 74546000369 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 74546000370 Walker A/P-loop; other site 74546000371 ATP binding site [chemical binding]; other site 74546000372 Q-loop/lid; other site 74546000373 ABC transporter signature motif; other site 74546000374 Walker B; other site 74546000375 D-loop; other site 74546000376 H-loop/switch region; other site 74546000377 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 74546000378 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 74546000379 active site 74546000380 phosphorylation site [posttranslational modification] 74546000381 intermolecular recognition site; other site 74546000382 dimerization interface [polypeptide binding]; other site 74546000383 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 74546000384 DNA binding site [nucleotide binding] 74546000385 DNA polymerase III subunit delta'; Validated; Region: PRK07399 74546000386 DNA polymerase III subunit delta'; Validated; Region: PRK08485 74546000387 thymidylate kinase; Validated; Region: tmk; PRK00698 74546000388 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 74546000389 TMP-binding site; other site 74546000390 ATP-binding site [chemical binding]; other site 74546000391 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 74546000392 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 74546000393 metal-binding site [ion binding] 74546000394 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 74546000395 Soluble P-type ATPase [General function prediction only]; Region: COG4087 74546000396 photosystem I assembly protein Ycf3; Provisional; Region: PRK02603 74546000397 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 74546000398 binding surface 74546000399 TPR motif; other site 74546000400 DNA repair protein RadA; Provisional; Region: PRK11823 74546000401 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 74546000402 Walker A motif/ATP binding site; other site 74546000403 ATP binding site [chemical binding]; other site 74546000404 Walker B motif; other site 74546000405 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 74546000406 Ycf27; Reviewed; Region: orf27; CHL00148 74546000407 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 74546000408 active site 74546000409 phosphorylation site [posttranslational modification] 74546000410 intermolecular recognition site; other site 74546000411 dimerization interface [polypeptide binding]; other site 74546000412 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 74546000413 DNA binding site [nucleotide binding] 74546000414 Fatty acid synthesis protein; Region: FA_synthesis; cl17261 74546000415 putative glycerol-3-phosphate acyltransferase PlsX; Provisional; Region: PRK13845 74546000416 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 74546000417 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 74546000418 dimer interface [polypeptide binding]; other site 74546000419 active site 74546000420 CoA binding pocket [chemical binding]; other site 74546000421 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 74546000422 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 74546000423 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 74546000424 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 74546000425 putative acyl-acceptor binding pocket; other site 74546000426 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 74546000427 Hypothetical chloroplast protein Ycf34; Region: Ycf34; pfam10718 74546000428 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 74546000429 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 74546000430 active site 74546000431 NTP binding site [chemical binding]; other site 74546000432 metal binding triad [ion binding]; metal-binding site 74546000433 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 74546000434 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 74546000435 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 74546000436 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 74546000437 active site lid residues [active] 74546000438 substrate binding pocket [chemical binding]; other site 74546000439 catalytic residues [active] 74546000440 substrate-Mg2+ binding site; other site 74546000441 aspartate-rich region 1; other site 74546000442 aspartate-rich region 2; other site 74546000443 phytoene desaturase; Region: phytoene_desat; TIGR02731 74546000444 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 74546000445 Cyanobacterial and plastid NDH-1 subunit M; Region: NdhM; pfam10664 74546000446 Protein of unknown function (DUF3172); Region: DUF3172; pfam11371 74546000447 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 74546000448 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 74546000449 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 74546000450 putative dimerization interface [polypeptide binding]; other site 74546000451 NnrU protein; Region: NnrU; cl17713 74546000452 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07376 74546000453 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 74546000454 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 74546000455 NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010 74546000456 NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK02546 74546000457 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 74546000458 ScpA/B protein; Region: ScpA_ScpB; cl00598 74546000459 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 74546000460 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 74546000461 active site 74546000462 Substrate binding site; other site 74546000463 Mg++ binding site; other site 74546000464 Left-handed parallel beta-Helix (LbH) domain of a group of proteins with similarity to glucose-1-phosphate adenylyltransferase: Included in this family are glucose-1-phosphate adenylyltransferase, mannose-1-phosphate guanylyltransferase, and the...; Region: LbH_G1P_AT_C_like; cd03356 74546000465 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 74546000466 FAD binding site [chemical binding]; other site 74546000467 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 74546000468 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 74546000469 DNA binding residues [nucleotide binding] 74546000470 dimerization interface [polypeptide binding]; other site 74546000471 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 74546000472 putative active site [active] 74546000473 putative metal binding residues [ion binding]; other site 74546000474 signature motif; other site 74546000475 putative dimer interface [polypeptide binding]; other site 74546000476 putative phosphate binding site [ion binding]; other site 74546000477 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02645 74546000478 ATP-NAD kinase; Region: NAD_kinase; pfam01513 74546000479 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 74546000480 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 74546000481 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 74546000482 NADH dehydrogenase subunit J; Provisional; Region: PRK06439 74546000483 NADH-plastoquinone oxidoreductase subunit I protein; Region: ndhI; TIGR00403 74546000484 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 74546000485 NADH dehydrogenase; Region: NADHdh; cl00469 74546000486 citrate synthase; Provisional; Region: PRK14036 74546000487 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 74546000488 oxalacetate binding site [chemical binding]; other site 74546000489 citrylCoA binding site [chemical binding]; other site 74546000490 coenzyme A binding site [chemical binding]; other site 74546000491 catalytic triad [active] 74546000492 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 74546000493 active site residue [active] 74546000494 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 74546000495 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 74546000496 pyridoxal 5'-phosphate binding site [chemical binding]; other site 74546000497 catalytic residue [active] 74546000498 Eukaryotic initiation factor 1 and related proteins; Region: eIF1_SUI1_like; cl00229 74546000499 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 74546000500 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 74546000501 Walker A/P-loop; other site 74546000502 ligand-binding site [chemical binding]; other site 74546000503 ATP binding site [chemical binding]; other site 74546000504 AIR carboxylase; Region: AIRC; pfam00731 74546000505 Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580 74546000506 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 74546000507 S-adenosylmethionine binding site [chemical binding]; other site 74546000508 Magnesium-protoporphyrin IX methyltransferase C-terminus; Region: Mg-por_mtran_C; pfam07109 74546000509 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 74546000510 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 74546000511 active site 74546000512 phosphorylation site [posttranslational modification] 74546000513 intermolecular recognition site; other site 74546000514 dimerization interface [polypeptide binding]; other site 74546000515 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 74546000516 DNA binding residues [nucleotide binding] 74546000517 dimerization interface [polypeptide binding]; other site 74546000518 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 74546000519 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 74546000520 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 74546000521 catalytic residue [active] 74546000522 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 74546000523 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 74546000524 S-adenosylmethionine binding site [chemical binding]; other site 74546000525 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 74546000526 NAD(P)H-quinone oxidoreductase subunit H; Validated; Region: PRK07415 74546000527 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 74546000528 active site 74546000529 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 74546000530 acyl-activating enzyme (AAE) consensus motif; other site 74546000531 AMP binding site [chemical binding]; other site 74546000532 active site 74546000533 CoA binding site [chemical binding]; other site 74546000534 O-succinylbenzoate synthase; Provisional; Region: PRK02714 74546000535 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 74546000536 active site 74546000537 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK07419 74546000538 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 74546000539 glutathione synthetase; Provisional; Region: PRK05246 74546000540 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 74546000541 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 74546000542 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 74546000543 GSH binding site [chemical binding]; other site 74546000544 catalytic residues [active] 74546000545 peptide chain release factor 2; Validated; Region: prfB; PRK00578 74546000546 PCRF domain; Region: PCRF; pfam03462 74546000547 RF-1 domain; Region: RF-1; pfam00472 74546000548 Protein of unknown function (DUF3285); Region: DUF3285; pfam11688 74546000549 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 74546000550 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 74546000551 Glutamine amidotransferase class-I; Region: GATase; pfam00117 74546000552 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 74546000553 glutamine binding [chemical binding]; other site 74546000554 catalytic triad [active] 74546000555 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 74546000556 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 74546000557 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 74546000558 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 74546000559 pyridoxal 5'-phosphate binding site [chemical binding]; other site 74546000560 homodimer interface [polypeptide binding]; other site 74546000561 catalytic residue [active] 74546000562 arginine-tRNA ligase; Region: PLN02286 74546000563 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 74546000564 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 74546000565 active site 74546000566 HIGH motif; other site 74546000567 KMSK motif region; other site 74546000568 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 74546000569 tRNA binding surface [nucleotide binding]; other site 74546000570 anticodon binding site; other site 74546000571 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 74546000572 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 74546000573 dimerization interface [polypeptide binding]; other site 74546000574 active site 74546000575 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 74546000576 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 74546000577 trmE is a tRNA modification GTPase; Region: trmE; cd04164 74546000578 G1 box; other site 74546000579 GTP/Mg2+ binding site [chemical binding]; other site 74546000580 Switch I region; other site 74546000581 G2 box; other site 74546000582 Switch II region; other site 74546000583 G3 box; other site 74546000584 G4 box; other site 74546000585 G5 box; other site 74546000586 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 74546000587 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 74546000588 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 74546000589 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 74546000590 Zn2+ binding site [ion binding]; other site 74546000591 Mg2+ binding site [ion binding]; other site 74546000592 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 74546000593 synthetase active site [active] 74546000594 NTP binding site [chemical binding]; other site 74546000595 metal binding site [ion binding]; metal-binding site 74546000596 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 74546000597 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 74546000598 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 74546000599 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 74546000600 Walker A/P-loop; other site 74546000601 ATP binding site [chemical binding]; other site 74546000602 Q-loop/lid; other site 74546000603 ABC transporter signature motif; other site 74546000604 Walker B; other site 74546000605 D-loop; other site 74546000606 H-loop/switch region; other site 74546000607 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 74546000608 Walker A/P-loop; other site 74546000609 ATP binding site [chemical binding]; other site 74546000610 Q-loop/lid; other site 74546000611 ABC transporter signature motif; other site 74546000612 Walker B; other site 74546000613 D-loop; other site 74546000614 H-loop/switch region; other site 74546000615 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 74546000616 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 74546000617 RNA binding surface [nucleotide binding]; other site 74546000618 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 74546000619 active site 74546000620 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 74546000621 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 74546000622 GTP/Mg2+ binding site [chemical binding]; other site 74546000623 G4 box; other site 74546000624 G5 box; other site 74546000625 G1 box; other site 74546000626 Switch I region; other site 74546000627 G2 box; other site 74546000628 G3 box; other site 74546000629 Switch II region; other site 74546000630 Phosphoglycerate kinase; Region: PGK; pfam00162 74546000631 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 74546000632 substrate binding site [chemical binding]; other site 74546000633 hinge regions; other site 74546000634 ADP binding site [chemical binding]; other site 74546000635 catalytic site [active] 74546000636 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 74546000637 UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell envelope biogenesis, outer membrane]; Region: MurG; COG0707 74546000638 active site 74546000639 homodimer interface [polypeptide binding]; other site 74546000640 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 74546000641 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 74546000642 pyridoxal 5'-phosphate binding site [chemical binding]; other site 74546000643 homodimer interface [polypeptide binding]; other site 74546000644 catalytic residue [active] 74546000645 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 74546000646 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 74546000647 quinone interaction residues [chemical binding]; other site 74546000648 active site 74546000649 catalytic residues [active] 74546000650 FMN binding site [chemical binding]; other site 74546000651 substrate binding site [chemical binding]; other site 74546000652 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 74546000653 RNA/DNA hybrid binding site [nucleotide binding]; other site 74546000654 active site 74546000655 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 74546000656 L11 interface [polypeptide binding]; other site 74546000657 putative EF-Tu interaction site [polypeptide binding]; other site 74546000658 putative EF-G interaction site [polypeptide binding]; other site 74546000659 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 74546000660 23S rRNA interface [nucleotide binding]; other site 74546000661 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 74546000662 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 74546000663 mRNA/rRNA interface [nucleotide binding]; other site 74546000664 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 74546000665 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 74546000666 23S rRNA interface [nucleotide binding]; other site 74546000667 L7/L12 interface [polypeptide binding]; other site 74546000668 putative thiostrepton binding site; other site 74546000669 L25 interface [polypeptide binding]; other site 74546000670 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 74546000671 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 74546000672 putative homodimer interface [polypeptide binding]; other site 74546000673 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 74546000674 heterodimer interface [polypeptide binding]; other site 74546000675 homodimer interface [polypeptide binding]; other site 74546000676 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 74546000677 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 74546000678 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 74546000679 Walker A motif; other site 74546000680 ATP binding site [chemical binding]; other site 74546000681 Walker B motif; other site 74546000682 arginine finger; other site 74546000683 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 74546000684 Walker A motif; other site 74546000685 ATP binding site [chemical binding]; other site 74546000686 Walker B motif; other site 74546000687 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 74546000688 enolase; Provisional; Region: eno; PRK00077 74546000689 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 74546000690 dimer interface [polypeptide binding]; other site 74546000691 metal binding site [ion binding]; metal-binding site 74546000692 substrate binding pocket [chemical binding]; other site 74546000693 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 74546000694 ABC1 family; Region: ABC1; pfam03109 74546000695 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 74546000696 active site 74546000697 ATP binding site [chemical binding]; other site 74546000698 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 74546000699 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 74546000700 Nitrogen regulatory protein P-II; Region: P-II; cl00412 74546000701 Domain of unknown function (DUF897); Region: DUF897; pfam05982 74546000702 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 74546000703 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 74546000704 Sulfate transporter family; Region: Sulfate_transp; pfam00916 74546000705 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 74546000706 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 74546000707 dimer interface [polypeptide binding]; other site 74546000708 allosteric magnesium binding site [ion binding]; other site 74546000709 active site 74546000710 aspartate-rich active site metal binding site; other site 74546000711 Schiff base residues; other site 74546000712 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 74546000713 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 74546000714 active site 74546000715 metal binding site [ion binding]; metal-binding site 74546000716 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 74546000717 MutS domain III; Region: MutS_III; pfam05192 74546000718 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 74546000719 Walker A/P-loop; other site 74546000720 ATP binding site [chemical binding]; other site 74546000721 Q-loop/lid; other site 74546000722 ABC transporter signature motif; other site 74546000723 Walker B; other site 74546000724 D-loop; other site 74546000725 H-loop/switch region; other site 74546000726 Smr domain; Region: Smr; pfam01713 74546000727 GTPase CgtA; Reviewed; Region: obgE; PRK12299 74546000728 GTP1/OBG; Region: GTP1_OBG; pfam01018 74546000729 Obg GTPase; Region: Obg; cd01898 74546000730 G1 box; other site 74546000731 GTP/Mg2+ binding site [chemical binding]; other site 74546000732 Switch I region; other site 74546000733 G2 box; other site 74546000734 G3 box; other site 74546000735 Switch II region; other site 74546000736 G4 box; other site 74546000737 CP12 domain; Region: CP12; pfam02672 74546000738 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 74546000739 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 74546000740 putative dimer interface [polypeptide binding]; other site 74546000741 N-terminal domain interface [polypeptide binding]; other site 74546000742 putative substrate binding pocket (H-site) [chemical binding]; other site 74546000743 aspartoacylase; Provisional; Region: PRK02259 74546000744 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 74546000745 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 74546000746 protein I interface; other site 74546000747 D2 interface; other site 74546000748 protein T interface; other site 74546000749 chlorophyll binding site; other site 74546000750 beta carotene binding site; other site 74546000751 pheophytin binding site; other site 74546000752 manganese-stabilizing polypeptide interface; other site 74546000753 CP43 interface; other site 74546000754 protein L interface; other site 74546000755 oxygen evolving complex binding site; other site 74546000756 bromide binding site; other site 74546000757 quinone binding site; other site 74546000758 Fe binding site [ion binding]; other site 74546000759 core light harvesting interface; other site 74546000760 cytochrome b559 alpha subunit interface; other site 74546000761 cytochrome c-550 interface; other site 74546000762 protein J interface; other site 74546000763 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 74546000764 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 74546000765 Tetramer interface [polypeptide binding]; other site 74546000766 active site 74546000767 FMN-binding site [chemical binding]; other site 74546000768 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 74546000769 active site 74546000770 intersubunit interface [polypeptide binding]; other site 74546000771 FtsH Extracellular; Region: FtsH_ext; pfam06480 74546000772 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 74546000773 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 74546000774 Walker A motif; other site 74546000775 ATP binding site [chemical binding]; other site 74546000776 Walker B motif; other site 74546000777 arginine finger; other site 74546000778 Peptidase family M41; Region: Peptidase_M41; pfam01434 74546000779 ATP-sulfurylase; Region: ATPS; cd00517 74546000780 ATP sulphurylase; Region: sopT; TIGR00339 74546000781 active site 74546000782 HXXH motif; other site 74546000783 flexible loop; other site 74546000784 Manganese-stabilising protein / photosystem II polypeptide; Region: MSP; cl03326 74546000785 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 74546000786 Flavoprotein; Region: Flavoprotein; pfam02441 74546000787 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 74546000788 Protein of unknown function (DUF2555); Region: DUF2555; pfam10742 74546000789 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 74546000790 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 74546000791 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 74546000792 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 74546000793 Fatty acid desaturase; Region: FA_desaturase; pfam00487 74546000794 Beta-carotene hydroxylase (CrtR), the carotenoid zeaxanthin biosynthetic enzyme catalyzes the addition of hydroxyl groups to the beta-ionone rings of beta-carotene to form zeaxanthin and is found in bacteria and red algae. Carotenoids are important...; Region: CrtR_beta-carotene-hydroxylase; cd03514 74546000795 putative di-iron ligands [ion binding]; other site 74546000796 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 74546000797 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 74546000798 active site 74546000799 HIGH motif; other site 74546000800 nucleotide binding site [chemical binding]; other site 74546000801 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 74546000802 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 74546000803 active site 74546000804 KMSKS motif; other site 74546000805 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 74546000806 tRNA binding surface [nucleotide binding]; other site 74546000807 anticodon binding site; other site 74546000808 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 74546000809 Protein of unknown function (DUF3177); Region: DUF3177; pfam11375 74546000810 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 74546000811 S-adenosylmethionine binding site [chemical binding]; other site 74546000812 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14317 74546000813 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 74546000814 active site 74546000815 substrate binding site [chemical binding]; other site 74546000816 metal binding site [ion binding]; metal-binding site 74546000817 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 74546000818 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 74546000819 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 74546000820 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 74546000821 trimer interface [polypeptide binding]; other site 74546000822 active site 74546000823 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; cl17276 74546000824 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 74546000825 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 74546000826 ligand binding site [chemical binding]; other site 74546000827 flexible hinge region; other site 74546000828 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 74546000829 putative switch regulator; other site 74546000830 non-specific DNA interactions [nucleotide binding]; other site 74546000831 DNA binding site [nucleotide binding] 74546000832 sequence specific DNA binding site [nucleotide binding]; other site 74546000833 putative cAMP binding site [chemical binding]; other site 74546000834 Protein of unknown function (DUF3084); Region: DUF3084; pfam11283 74546000835 Uncharacterized protein family (UPF0081); Region: UPF0081; cl17278 74546000836 Protein of unknown function (DUF3146); Region: DUF3146; pfam11344 74546000837 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 74546000838 putative active site [active] 74546000839 catalytic residue [active] 74546000840 photosystem II reaction center protein H; Provisional; Region: psbH; PRK02624 74546000841 photosystem II reaction center protein N; Provisional; Region: psbN; PRK13183 74546000842 photosystem II reaction center I protein I; Provisional; Region: psbI; PRK02655 74546000843 Protein of unknown function (DUF3769); Region: DUF3769; pfam12600 74546000844 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 74546000845 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 74546000846 substrate binding site [chemical binding]; other site 74546000847 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 74546000848 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 74546000849 substrate binding site [chemical binding]; other site 74546000850 ligand binding site [chemical binding]; other site 74546000851 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 74546000852 competence damage-inducible protein A; Provisional; Region: PRK00549 74546000853 putative MPT binding site; other site 74546000854 Competence-damaged protein; Region: CinA; pfam02464 74546000855 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 74546000856 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 74546000857 dimer interface [polypeptide binding]; other site 74546000858 active site 74546000859 glycine-pyridoxal phosphate binding site [chemical binding]; other site 74546000860 folate binding site [chemical binding]; other site 74546000861 Protein of unknown function (DUF3181); Region: DUF3181; pfam11378 74546000862 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 74546000863 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 74546000864 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 74546000865 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 74546000866 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Provisional; Region: PRK13371 74546000867 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 74546000868 Predicted membrane protein [Function unknown]; Region: COG2259 74546000869 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 74546000870 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 74546000871 purine monophosphate binding site [chemical binding]; other site 74546000872 dimer interface [polypeptide binding]; other site 74546000873 putative catalytic residues [active] 74546000874 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 74546000875 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 74546000876 Predicted esterase [General function prediction only]; Region: COG0400 74546000877 putative hydrolase; Provisional; Region: PRK11460 74546000878 Serine hydrolase (FSH1); Region: FSH1; pfam03959 74546000879 Protein of unknown function (DUF3155); Region: DUF3155; pfam11352 74546000880 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 74546000881 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 74546000882 phosphorylation site [posttranslational modification] 74546000883 dimer interface [polypeptide binding]; other site 74546000884 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 74546000885 ATP binding site [chemical binding]; other site 74546000886 Mg2+ binding site [ion binding]; other site 74546000887 G-X-G motif; other site 74546000888 cobalamin synthase; Reviewed; Region: cobS; PRK00235 74546000889 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 74546000890 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 74546000891 Photosystem II 4 kDa reaction centre component; Region: PsbK; cl03641 74546000892 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 74546000893 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 74546000894 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 74546000895 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 74546000896 Domain of unknown function DUF21; Region: DUF21; pfam01595 74546000897 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 74546000898 Transporter associated domain; Region: CorC_HlyC; smart01091 74546000899 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 74546000900 active site 74546000901 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 74546000902 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 74546000903 RecB family nuclease, putative, TM0106 family; Region: TIGR03491 74546000904 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 74546000905 Domain of unknown function (DUF4332); Region: DUF4332; pfam14229 74546000906 RNase_H superfamily; Region: RNase_H_2; pfam13482 74546000907 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 74546000908 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 74546000909 active site 74546000910 substrate binding site [chemical binding]; other site 74546000911 metal binding site [ion binding]; metal-binding site 74546000912 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 74546000913 active site 74546000914 dimerization interface [polypeptide binding]; other site 74546000915 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 74546000916 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 74546000917 imidazoleglycerol-phosphate dehydratase; Region: PLN02800 74546000918 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 74546000919 putative active site pocket [active] 74546000920 4-fold oligomerization interface [polypeptide binding]; other site 74546000921 metal binding residues [ion binding]; metal-binding site 74546000922 3-fold/trimer interface [polypeptide binding]; other site 74546000923 enoyl-(acyl carrier protein) reductase; Validated; Region: PRK07370 74546000924 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 74546000925 NAD binding site [chemical binding]; other site 74546000926 homotetramer interface [polypeptide binding]; other site 74546000927 homodimer interface [polypeptide binding]; other site 74546000928 substrate binding site [chemical binding]; other site 74546000929 active site 74546000930 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 74546000931 putative catalytic residue [active] 74546000932 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 74546000933 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 74546000934 inhibitor-cofactor binding pocket; inhibition site 74546000935 pyridoxal 5'-phosphate binding site [chemical binding]; other site 74546000936 catalytic residue [active] 74546000937 deoxyribodipyrimidine photo-lyase, 8-HDF type; Region: photolyase_8HDF; TIGR03556 74546000938 DNA photolyase; Region: DNA_photolyase; pfam00875 74546000939 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 74546000940 dimer interface [polypeptide binding]; other site 74546000941 ADP-ribose binding site [chemical binding]; other site 74546000942 active site 74546000943 nudix motif; other site 74546000944 metal binding site [ion binding]; metal-binding site 74546000945 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 74546000946 catalytic center binding site [active] 74546000947 ATP binding site [chemical binding]; other site 74546000948 Protein of unknown function (DUF444); Region: DUF444; cl17371 74546000949 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 74546000950 metal ion-dependent adhesion site (MIDAS); other site 74546000951 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 74546000952 mce related protein; Region: MCE; pfam02470 74546000953 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 74546000954 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 74546000955 Walker A/P-loop; other site 74546000956 ATP binding site [chemical binding]; other site 74546000957 Q-loop/lid; other site 74546000958 ABC transporter signature motif; other site 74546000959 Walker B; other site 74546000960 D-loop; other site 74546000961 H-loop/switch region; other site 74546000962 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 74546000963 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 74546000964 phosphate binding site [ion binding]; other site 74546000965 putative substrate binding pocket [chemical binding]; other site 74546000966 dimer interface [polypeptide binding]; other site 74546000967 NADH dehydrogenase subunit J; Provisional; Region: PRK12494 74546000968 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 74546000969 NADH dehydrogenase subunit K; Region: ndhK; CHL00023 74546000970 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 74546000971 Rubredoxin [Energy production and conversion]; Region: COG1773 74546000972 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 74546000973 iron binding site [ion binding]; other site 74546000974 Ycf48-like protein; Provisional; Region: PRK13684 74546000975 cytochrome b559 subunit alpha; Provisional; Region: psbE; PRK02557 74546000976 Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits; Region: Cytochrom_B559; pfam00283 74546000977 Lumenal portion of Cytochrome b559, alpha (gene psbE) subunit; Region: Cytochrom_B559a; pfam00284 74546000978 cytochrome b559 subunit beta; Provisional; Region: psbF; PRK02561 74546000979 photosystem II reaction center L; Provisional; Region: psbL; PRK00753 74546000980 photosystem II reaction center protein J; Provisional; Region: PRK02565 74546000981 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 74546000982 pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169 74546000983 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 74546000984 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 74546000985 dimerization interface [polypeptide binding]; other site 74546000986 ATP binding site [chemical binding]; other site 74546000987 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 74546000988 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 74546000989 active site 74546000990 NTP binding site [chemical binding]; other site 74546000991 metal binding triad [ion binding]; metal-binding site 74546000992 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 74546000993 Part of AAA domain; Region: AAA_19; pfam13245 74546000994 Family description; Region: UvrD_C_2; pfam13538 74546000995 Phycobilisome protein; Region: Phycobilisome; cl08227 74546000996 CpeS-like protein; Region: CpeS; pfam09367 74546000997 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 74546000998 active site 74546000999 oxyanion hole [active] 74546001000 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 74546001001 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 74546001002 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 74546001003 D-xylulose kinase; Region: XylB; TIGR01312 74546001004 nucleotide binding site [chemical binding]; other site 74546001005 S-adenosylmethionine synthetase; Validated; Region: PRK05250 74546001006 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 74546001007 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 74546001008 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 74546001009 30S ribosomal protein S1; Reviewed; Region: PRK07400 74546001010 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 74546001011 RNA binding site [nucleotide binding]; other site 74546001012 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 74546001013 RNA binding site [nucleotide binding]; other site 74546001014 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 74546001015 RNA binding site [nucleotide binding]; other site 74546001016 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 74546001017 ATP cone domain; Region: ATP-cone; pfam03477 74546001018 photosystem II reaction center protein T; Reviewed; Region: psbT; PRK11875 74546001019 photosystem II chlorophyll-binding protein CP47; Region: PS_II_CP47; TIGR03039 74546001020 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 74546001021 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 74546001022 catalytic loop [active] 74546001023 iron binding site [ion binding]; other site 74546001024 photosystem II reaction center protein M; Provisional; Region: psbM; PRK14094 74546001025 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 74546001026 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 74546001027 S-adenosylmethionine binding site [chemical binding]; other site 74546001028 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 74546001029 cell division topological specificity factor MinE; Provisional; Region: PRK13988 74546001030 septum site-determining protein MinD; Region: minD_bact; TIGR01968 74546001031 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 74546001032 P-loop; other site 74546001033 ADP binding residues [chemical binding]; other site 74546001034 Switch I; other site 74546001035 Switch II; other site 74546001036 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 74546001037 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 74546001038 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 74546001039 Zn2+ binding site [ion binding]; other site 74546001040 Mg2+ binding site [ion binding]; other site 74546001041 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 74546001042 C-terminal peptidase (prc); Region: prc; TIGR00225 74546001043 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 74546001044 protein binding site [polypeptide binding]; other site 74546001045 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 74546001046 Catalytic dyad [active] 74546001047 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 74546001048 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 74546001049 Qi binding site; other site 74546001050 intrachain domain interface; other site 74546001051 interchain domain interface [polypeptide binding]; other site 74546001052 heme bH binding site [chemical binding]; other site 74546001053 heme bL binding site [chemical binding]; other site 74546001054 Qo binding site; other site 74546001055 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 74546001056 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 74546001057 interchain domain interface [polypeptide binding]; other site 74546001058 intrachain domain interface; other site 74546001059 Qi binding site; other site 74546001060 Qo binding site; other site 74546001061 Alkaline and neutral invertase; Region: Glyco_hydro_100; pfam12899 74546001062 formamidopyrimidine-DNA glycosylase; Provisional; Region: PRK13945 74546001063 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 74546001064 DNA binding site [nucleotide binding] 74546001065 catalytic residue [active] 74546001066 H2TH interface [polypeptide binding]; other site 74546001067 putative catalytic residues [active] 74546001068 turnover-facilitating residue; other site 74546001069 intercalation triad [nucleotide binding]; other site 74546001070 8OG recognition residue [nucleotide binding]; other site 74546001071 putative reading head residues; other site 74546001072 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 74546001073 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 74546001074 photosystem I reaction center subunit IV; Provisional; Region: PRK02749 74546001075 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 74546001076 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 74546001077 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 74546001078 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 74546001079 NAD(P) binding site [chemical binding]; other site 74546001080 catalytic residues [active] 74546001081 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 74546001082 Coenzyme A binding pocket [chemical binding]; other site 74546001083 Protein of unknown function (DUF3104); Region: DUF3104; pfam11302 74546001084 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07376 74546001085 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 74546001086 dinuclear metal binding motif [ion binding]; other site 74546001087 conserved hypothetical protein, TIGR03894 family; Region: chp_P_marinus_1 74546001088 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 74546001089 carotene isomerase; Region: carot_isom; TIGR02730 74546001090 Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862 74546001091 twin arginine translocase protein A; Provisional; Region: tatA; PRK14857 74546001092 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 74546001093 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 74546001094 catalytic triad [active] 74546001095 Protein of unknown function (DUF4090); Region: DUF4090; pfam13319 74546001096 hypothetical protein; Provisional; Region: PRK09256 74546001097 Protein of unknown function (DUF1651); Region: DUF1651; pfam07864 74546001098 CAAX protease self-immunity; Region: Abi; cl00558 74546001099 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 74546001100 TAP-like protein; Region: Abhydrolase_4; pfam08386 74546001101 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 74546001102 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 74546001103 dimer interface [polypeptide binding]; other site 74546001104 substrate binding site [chemical binding]; other site 74546001105 ATP binding site [chemical binding]; other site 74546001106 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 74546001107 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 74546001108 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 74546001109 Domain of unknown function (DUF4268); Region: DUF4268; pfam14088 74546001110 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 74546001111 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 74546001112 additional DNA contacts [nucleotide binding]; other site 74546001113 mismatch recognition site; other site 74546001114 active site 74546001115 zinc binding site [ion binding]; other site 74546001116 DNA intercalation site [nucleotide binding]; other site 74546001117 Z1 domain; Region: Z1; pfam10593 74546001118 Domain of unknown function (DUF4420); Region: DUF4420; pfam14390 74546001119 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 74546001120 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 74546001121 cofactor binding site; other site 74546001122 DNA binding site [nucleotide binding] 74546001123 substrate interaction site [chemical binding]; other site 74546001124 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 74546001125 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 74546001126 active site 74546001127 DNA binding site [nucleotide binding] 74546001128 Int/Topo IB signature motif; other site 74546001129 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 74546001130 Dehydroquinase class II; Region: DHquinase_II; pfam01220 74546001131 active site 74546001132 trimer interface [polypeptide binding]; other site 74546001133 dimer interface [polypeptide binding]; other site 74546001134 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 74546001135 active site 74546001136 dinuclear metal binding site [ion binding]; other site 74546001137 dimerization interface [polypeptide binding]; other site 74546001138 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 74546001139 active site 74546001140 SAM binding site [chemical binding]; other site 74546001141 homodimer interface [polypeptide binding]; other site 74546001142 Domain of unknown function (DUF1823); Region: DUF1823; pfam08853 74546001143 GTP-binding protein Der; Reviewed; Region: PRK00093 74546001144 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 74546001145 G1 box; other site 74546001146 GTP/Mg2+ binding site [chemical binding]; other site 74546001147 Switch I region; other site 74546001148 G2 box; other site 74546001149 Switch II region; other site 74546001150 G3 box; other site 74546001151 G4 box; other site 74546001152 G5 box; other site 74546001153 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 74546001154 G1 box; other site 74546001155 GTP/Mg2+ binding site [chemical binding]; other site 74546001156 Switch I region; other site 74546001157 G2 box; other site 74546001158 G3 box; other site 74546001159 Switch II region; other site 74546001160 G4 box; other site 74546001161 G5 box; other site 74546001162 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 74546001163 Protein of unknown function (DUF3539); Region: DUF3539; pfam12058 74546001164 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 74546001165 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 74546001166 catalytic residue [active] 74546001167 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 74546001168 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 74546001169 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 74546001170 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 74546001171 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 74546001172 Recombination protein O N terminal; Region: RecO_N; pfam11967 74546001173 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 74546001174 Recombination protein O C terminal; Region: RecO_C; pfam02565 74546001175 Class I aldolases; Region: Aldolase_Class_I; cl17187 74546001176 catalytic residue [active] 74546001177 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 74546001178 30S subunit binding site; other site 74546001179 lipoate-protein ligase B; Provisional; Region: PRK14344 74546001180 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 74546001181 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 74546001182 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 74546001183 acyl-activating enzyme (AAE) consensus motif; other site 74546001184 acyl-activating enzyme (AAE) consensus motif; other site 74546001185 putative AMP binding site [chemical binding]; other site 74546001186 putative active site [active] 74546001187 putative CoA binding site [chemical binding]; other site 74546001188 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 74546001189 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 74546001190 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 74546001191 E3 interaction surface; other site 74546001192 lipoyl attachment site [posttranslational modification]; other site 74546001193 e3 binding domain; Region: E3_binding; pfam02817 74546001194 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 74546001195 Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547 74546001196 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 74546001197 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 74546001198 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 74546001199 dimer interface [polypeptide binding]; other site 74546001200 pyridoxal 5'-phosphate binding site [chemical binding]; other site 74546001201 catalytic residue [active] 74546001202 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 74546001203 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 74546001204 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 74546001205 catalytic residue [active] 74546001206 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 74546001207 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 74546001208 homodimer interface [polypeptide binding]; other site 74546001209 substrate-cofactor binding pocket; other site 74546001210 pyridoxal 5'-phosphate binding site [chemical binding]; other site 74546001211 catalytic residue [active] 74546001212 ribosomal protein S4; Reviewed; Region: rps4; CHL00113 74546001213 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 74546001214 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 74546001215 RNA binding surface [nucleotide binding]; other site 74546001216 hypothetical protein; Provisional; Region: PRK14390 74546001217 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 74546001218 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 74546001219 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 74546001220 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 74546001221 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 74546001222 C factor cell-cell signaling protein; Provisional; Region: PRK09009 74546001223 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 74546001224 NAD(P) binding site [chemical binding]; other site 74546001225 active site 74546001226 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 74546001227 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 74546001228 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 74546001229 catalytic residue [active] 74546001230 Methyltransferase domain; Region: Methyltransf_31; pfam13847 74546001231 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 74546001232 S-adenosylmethionine binding site [chemical binding]; other site 74546001233 NifU-like domain; Region: NifU; pfam01106 74546001234 malate:quinone oxidoreductase; Validated; Region: PRK05257 74546001235 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 74546001236 GTP-binding protein LepA; Provisional; Region: PRK05433 74546001237 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 74546001238 G1 box; other site 74546001239 putative GEF interaction site [polypeptide binding]; other site 74546001240 GTP/Mg2+ binding site [chemical binding]; other site 74546001241 Switch I region; other site 74546001242 G2 box; other site 74546001243 G3 box; other site 74546001244 Switch II region; other site 74546001245 G4 box; other site 74546001246 G5 box; other site 74546001247 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 74546001248 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 74546001249 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 74546001250 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 74546001251 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 74546001252 dimer interface [polypeptide binding]; other site 74546001253 conserved gate region; other site 74546001254 ABC-ATPase subunit interface; other site 74546001255 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 74546001256 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 74546001257 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 74546001258 Protein of unknown function, DUF393; Region: DUF393; pfam04134 74546001259 TIGR03643 family protein; Region: TIGR03643 74546001260 Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013 74546001261 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 74546001262 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 74546001263 16S rRNA methyltransferase B; Provisional; Region: PRK14901 74546001264 NusB family; Region: NusB; pfam01029 74546001265 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 74546001266 S-adenosylmethionine binding site [chemical binding]; other site 74546001267 Transglycosylase; Region: Transgly; pfam00912 74546001268 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 74546001269 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 74546001270 bacteriochlorophyll/chlorophyll a synthase; Reviewed; Region: PRK07566 74546001271 UbiA prenyltransferase family; Region: UbiA; pfam01040 74546001272 Protein of unknown function (DUF2862); Region: DUF2862; pfam11061 74546001273 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 74546001274 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 74546001275 substrate binding site [chemical binding]; other site 74546001276 glutamase interaction surface [polypeptide binding]; other site 74546001277 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 74546001278 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 74546001279 S-adenosylmethionine binding site [chemical binding]; other site 74546001280 Protein of unknown function (DUF721); Region: DUF721; pfam05258 74546001281 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 74546001282 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 74546001283 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 74546001284 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 74546001285 Walker A/P-loop; other site 74546001286 ATP binding site [chemical binding]; other site 74546001287 Q-loop/lid; other site 74546001288 ABC transporter signature motif; other site 74546001289 Walker B; other site 74546001290 D-loop; other site 74546001291 H-loop/switch region; other site 74546001292 NAD(P)H-quinone oxidoreductase subunit 2; Provisional; Region: PRK02504 74546001293 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 74546001294 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 74546001295 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 74546001296 active site 74546001297 interdomain interaction site; other site 74546001298 putative metal-binding site [ion binding]; other site 74546001299 nucleotide binding site [chemical binding]; other site 74546001300 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 74546001301 domain I; other site 74546001302 DNA binding groove [nucleotide binding] 74546001303 phosphate binding site [ion binding]; other site 74546001304 domain II; other site 74546001305 domain III; other site 74546001306 nucleotide binding site [chemical binding]; other site 74546001307 catalytic site [active] 74546001308 domain IV; other site 74546001309 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 74546001310 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 74546001311 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 74546001312 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 74546001313 putative dimer interface [polypeptide binding]; other site 74546001314 active site pocket [active] 74546001315 putative cataytic base [active] 74546001316 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 74546001317 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 74546001318 active site 74546001319 catalytic tetrad [active] 74546001320 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 74546001321 Lumazine binding domain; Region: Lum_binding; pfam00677 74546001322 Lumazine binding domain; Region: Lum_binding; pfam00677 74546001323 AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250 74546001324 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 74546001325 Subunit I/III interface [polypeptide binding]; other site 74546001326 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 74546001327 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 74546001328 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 74546001329 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 74546001330 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 74546001331 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 74546001332 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 74546001333 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 74546001334 UbiA prenyltransferase family; Region: UbiA; pfam01040 74546001335 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 74546001336 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 74546001337 Walker A/P-loop; other site 74546001338 ATP binding site [chemical binding]; other site 74546001339 Q-loop/lid; other site 74546001340 ABC transporter signature motif; other site 74546001341 Walker B; other site 74546001342 D-loop; other site 74546001343 H-loop/switch region; other site 74546001344 ABC-2 type transporter; Region: ABC2_membrane; cl17235 74546001345 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 74546001346 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 74546001347 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 74546001348 ring oligomerisation interface [polypeptide binding]; other site 74546001349 ATP/Mg binding site [chemical binding]; other site 74546001350 stacking interactions; other site 74546001351 hinge regions; other site 74546001352 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 74546001353 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 74546001354 NAD(P) binding site [chemical binding]; other site 74546001355 homotetramer interface [polypeptide binding]; other site 74546001356 homodimer interface [polypeptide binding]; other site 74546001357 active site 74546001358 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 74546001359 substrate binding site; other site 74546001360 dimer interface; other site 74546001361 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 74546001362 dimer interface [polypeptide binding]; other site 74546001363 catalytic triad [active] 74546001364 prenyltransferase; Reviewed; Region: ubiA; PRK12873 74546001365 UbiA prenyltransferase family; Region: UbiA; pfam01040 74546001366 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 74546001367 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 74546001368 Helix-turn-helix domain; Region: HTH_25; pfam13413 74546001369 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 74546001370 active site 74546001371 SAM binding site [chemical binding]; other site 74546001372 homodimer interface [polypeptide binding]; other site 74546001373 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 74546001374 apocytochrome f; Reviewed; Region: PRK02693 74546001375 cytochrome f; Region: petA; CHL00037 74546001376 cytochrome b6-f complex iron-sulfur subunit; Provisional; Region: PRK13474 74546001377 Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802 74546001378 Iron-sulfur protein (ISP) component of the b6f complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The cytochrome b6f complex from Mastigocladus laminosus, a thermophilic cyanobacterium; Region: Rieske_cytochrome_b6f; cd03471 74546001379 cytochrome b subunit interaction site [polypeptide binding]; other site 74546001380 [2Fe-2S] cluster binding site [ion binding]; other site 74546001381 Protein of unknown function (DUF3067); Region: DUF3067; pfam11267 74546001382 Sec-independent translocase component C; Provisional; Region: tatC; CHL00182 74546001383 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 74546001384 Domain of unknown function (DUF814); Region: DUF814; pfam05670 74546001385 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 74546001386 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 74546001387 catalytic site [active] 74546001388 G-X2-G-X-G-K; other site 74546001389 photosystem I reaction center subunit IX; Provisional; Region: PRK02733 74546001390 Photosystem I reaction centre subunit III; Region: PSI_PsaF; cl03627 74546001391 UGMP family protein; Validated; Region: PRK09604 74546001392 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 74546001393 putative high light inducible protein; Region: PHA02337 74546001394 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 74546001395 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 74546001396 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 74546001397 HIGH motif; other site 74546001398 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 74546001399 active site 74546001400 KMSKS motif; other site 74546001401 Src Homology 3 domain superfamily; Region: SH3; cl17036 74546001402 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 74546001403 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 74546001404 active site 74546001405 short chain dehydrogenase; Provisional; Region: PRK12367 74546001406 BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857 74546001407 DRTGG domain; Region: DRTGG; pfam07085 74546001408 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 74546001409 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 74546001410 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 74546001411 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 74546001412 SPFH domain / Band 7 family; Region: Band_7; pfam01145 74546001413 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 74546001414 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 74546001415 inhibitor-cofactor binding pocket; inhibition site 74546001416 pyridoxal 5'-phosphate binding site [chemical binding]; other site 74546001417 catalytic residue [active] 74546001418 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 74546001419 putative catalytic site [active] 74546001420 putative phosphate binding site [ion binding]; other site 74546001421 active site 74546001422 metal binding site A [ion binding]; metal-binding site 74546001423 DNA binding site [nucleotide binding] 74546001424 putative AP binding site [nucleotide binding]; other site 74546001425 putative metal binding site B [ion binding]; other site 74546001426 hypothetical protein; Provisional; Region: PRK04194 74546001427 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 74546001428 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 74546001429 dimer interface [polypeptide binding]; other site 74546001430 conserved gate region; other site 74546001431 putative PBP binding loops; other site 74546001432 ABC-ATPase subunit interface; other site 74546001433 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 74546001434 dimer interface [polypeptide binding]; other site 74546001435 conserved gate region; other site 74546001436 putative PBP binding loops; other site 74546001437 ABC-ATPase subunit interface; other site 74546001438 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 74546001439 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 74546001440 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 74546001441 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914 74546001442 aromatic arch; other site 74546001443 DCoH dimer interaction site [polypeptide binding]; other site 74546001444 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 74546001445 DCoH tetramer interaction site [polypeptide binding]; other site 74546001446 substrate binding site [chemical binding]; other site 74546001447 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 74546001448 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 74546001449 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 74546001450 active site 74546001451 Zn binding site [ion binding]; other site 74546001452 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 74546001453 dimer interface [polypeptide binding]; other site 74546001454 substrate binding site [chemical binding]; other site 74546001455 metal binding sites [ion binding]; metal-binding site 74546001456 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 74546001457 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 74546001458 domain interfaces; other site 74546001459 active site 74546001460 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 74546001461 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 74546001462 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 74546001463 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 74546001464 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 74546001465 DNA binding residues [nucleotide binding] 74546001466 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 74546001467 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 74546001468 ATP binding site [chemical binding]; other site 74546001469 putative Mg++ binding site [ion binding]; other site 74546001470 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 74546001471 ATP-binding site [chemical binding]; other site 74546001472 Protein of unknown function (DUF3153); Region: DUF3153; pfam11353 74546001473 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 74546001474 feedback inhibition sensing region; other site 74546001475 homohexameric interface [polypeptide binding]; other site 74546001476 nucleotide binding site [chemical binding]; other site 74546001477 N-acetyl-L-glutamate binding site [chemical binding]; other site 74546001478 Protein of unknown function (DUF2854); Region: DUF2854; pfam11016 74546001479 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 74546001480 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 74546001481 ssDNA binding site [nucleotide binding]; other site 74546001482 dimer interface [polypeptide binding]; other site 74546001483 tetramer (dimer of dimers) interface [polypeptide binding]; other site 74546001484 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 74546001485 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 74546001486 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 74546001487 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 74546001488 substrate binding site [chemical binding]; other site 74546001489 ATP binding site [chemical binding]; other site 74546001490 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 74546001491 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 74546001492 GDP-binding site [chemical binding]; other site 74546001493 ACT binding site; other site 74546001494 IMP binding site; other site 74546001495 photosystem II protein Psb27; Region: PS_II_psb27; TIGR03044 74546001496 prolyl-tRNA synthetase; Provisional; Region: PRK09194 74546001497 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 74546001498 motif 1; other site 74546001499 dimer interface [polypeptide binding]; other site 74546001500 active site 74546001501 motif 2; other site 74546001502 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 74546001503 putative deacylase active site [active] 74546001504 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 74546001505 motif 3; other site 74546001506 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 74546001507 anticodon binding site; other site 74546001508 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 74546001509 dimer interface [polypeptide binding]; other site 74546001510 substrate binding site [chemical binding]; other site 74546001511 metal binding sites [ion binding]; metal-binding site 74546001512 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 74546001513 ArsC family; Region: ArsC; pfam03960 74546001514 putative ArsC-like catalytic residues; other site 74546001515 putative TRX-like catalytic residues [active] 74546001516 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 74546001517 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 74546001518 Catalytic site [active] 74546001519 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 74546001520 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 74546001521 catalytic core [active] 74546001522 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 74546001523 catalytic core [active] 74546001524 CAAX protease self-immunity; Region: Abi; pfam02517 74546001525 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 74546001526 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 74546001527 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 74546001528 transaldolase-like protein; Provisional; Region: PTZ00411 74546001529 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 74546001530 active site 74546001531 dimer interface [polypeptide binding]; other site 74546001532 catalytic residue [active] 74546001533 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 74546001534 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 74546001535 ribosome recycling factor; Reviewed; Region: frr; PRK00083 74546001536 hinge region; other site 74546001537 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 74546001538 putative nucleotide binding site [chemical binding]; other site 74546001539 uridine monophosphate binding site [chemical binding]; other site 74546001540 homohexameric interface [polypeptide binding]; other site 74546001541 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 74546001542 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 74546001543 homodimer interface [polypeptide binding]; other site 74546001544 Walker A motif; other site 74546001545 ATP binding site [chemical binding]; other site 74546001546 hydroxycobalamin binding site [chemical binding]; other site 74546001547 Walker B motif; other site 74546001548 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 74546001549 active site 74546001550 catalytic residues [active] 74546001551 DNA binding site [nucleotide binding] 74546001552 Int/Topo IB signature motif; other site 74546001553 ferrochelatase; Reviewed; Region: hemH; PRK00035 74546001554 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 74546001555 C-terminal domain interface [polypeptide binding]; other site 74546001556 active site 74546001557 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 74546001558 active site 74546001559 N-terminal domain interface [polypeptide binding]; other site 74546001560 acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK07418 74546001561 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 74546001562 PYR/PP interface [polypeptide binding]; other site 74546001563 dimer interface [polypeptide binding]; other site 74546001564 TPP binding site [chemical binding]; other site 74546001565 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 74546001566 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 74546001567 TPP-binding site [chemical binding]; other site 74546001568 dimer interface [polypeptide binding]; other site 74546001569 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 74546001570 Protein of unknown function (DUF1092); Region: DUF1092; pfam06485 74546001571 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 74546001572 RNA binding site [nucleotide binding]; other site 74546001573 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 74546001574 RNA binding site [nucleotide binding]; other site 74546001575 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 74546001576 RNA binding site [nucleotide binding]; other site 74546001577 Creatinine amidohydrolase; Region: Creatininase; pfam02633 74546001578 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 74546001579 dinuclear metal binding motif [ion binding]; other site 74546001580 acyl-ACP reductase; Provisional; Region: PRK14982 74546001581 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 74546001582 NAD(P) binding pocket [chemical binding]; other site 74546001583 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 74546001584 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 74546001585 short chain dehydrogenase; Provisional; Region: PRK07454 74546001586 classical (c) SDRs; Region: SDR_c; cd05233 74546001587 NAD(P) binding site [chemical binding]; other site 74546001588 active site 74546001589 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 74546001590 GTP cyclohydrolase I; Provisional; Region: PLN03044 74546001591 active site 74546001592 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 74546001593 active site 74546001594 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 74546001595 active site 74546001596 putative substrate binding region [chemical binding]; other site 74546001597 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 74546001598 photosystem I reaction center subunit XII; Reviewed; Region: psaM; PRK11878 74546001599 protochlorophyllide oxidoreductase; Validated; Region: PRK07453 74546001600 light-dependent protochlorophyllide reductase; Region: LPOR; TIGR01289 74546001601 NAD(P) binding site [chemical binding]; other site 74546001602 active site 74546001603 protochlorophyllide reductase iron-sulfur ATP-binding protein; Provisional; Region: chlL; PRK13185 74546001604 This family of proteins contains bchL and chlL. Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. Three genes, bchL, bchN and bchB, are...; Region: Bchl_like; cd02032 74546001605 P-loop; other site 74546001606 light-independent protochlorophyllide reductase subunit B; Provisional; Region: PRK02910 74546001607 Pchlide_reductase_B: B protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_B; cd01981 74546001608 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 74546001609 light-independent protochlorophyllide reductase subunit N; Provisional; Region: PRK02842 74546001610 light-independent protochlorophyllide reductase, N subunit; Region: DPOR_bchN; TIGR01279 74546001611 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 1; Region: BMC_like_1_repeat1; cd07051 74546001612 putative hexamer interface [polypeptide binding]; other site 74546001613 putative hexagonal pore; other site 74546001614 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 2; Region: BMC_like_1_repeat2; cd07052 74546001615 putative hexamer interface [polypeptide binding]; other site 74546001616 putative hexagonal pore; other site 74546001617 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 74546001618 active site 74546001619 dimerization interface [polypeptide binding]; other site 74546001620 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 74546001621 Carboxysome Shell 1 (CsoS1); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CsoS1; cd07058 74546001622 Hexamer interface [polypeptide binding]; other site 74546001623 Hexagonal pore residue; other site 74546001624 Hexagonal pore; other site 74546001625 ribulose bisophosphate carboxylase; Reviewed; Region: rbcL; PRK04208 74546001626 Ribulose bisphosphate carboxylase large chain; Region: RuBisCO_large; cl08232 74546001627 dimer interface [polypeptide binding]; other site 74546001628 catalytic residue [active] 74546001629 metal binding site [ion binding]; metal-binding site 74546001630 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527 74546001631 multimerization interface [polypeptide binding]; other site 74546001632 Carboxysome shell peptide mid-region; Region: CsoS2_M; pfam12288 74546001633 Carboxysome shell peptide mid-region; Region: CsoS2_M; pfam12288 74546001634 Carboxysome Shell Carbonic Anhydrase; Region: CsoSCA; pfam08936 74546001635 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 74546001636 Hexamer/Pentamer interface [polypeptide binding]; other site 74546001637 central pore; other site 74546001638 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 74546001639 Hexamer/Pentamer interface [polypeptide binding]; other site 74546001640 central pore; other site 74546001641 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cl00942 74546001642 DCoH dimer interaction site [polypeptide binding]; other site 74546001643 aromatic arch; other site 74546001644 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 74546001645 DCoH tetramer interaction site [polypeptide binding]; other site 74546001646 substrate binding site [chemical binding]; other site 74546001647 Protein of unknown function (DUF3136); Region: DUF3136; pfam11334 74546001648 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 74546001649 homotrimer interaction site [polypeptide binding]; other site 74546001650 putative active site [active] 74546001651 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 74546001652 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 74546001653 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 74546001654 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 74546001655 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 74546001656 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 74546001657 Walker A/P-loop; other site 74546001658 ATP binding site [chemical binding]; other site 74546001659 Q-loop/lid; other site 74546001660 ABC transporter signature motif; other site 74546001661 Walker B; other site 74546001662 D-loop; other site 74546001663 H-loop/switch region; other site 74546001664 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 74546001665 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 74546001666 Coenzyme A binding pocket [chemical binding]; other site 74546001667 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 74546001668 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 74546001669 Probable Catalytic site; other site 74546001670 transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282 74546001671 DnaA N-terminal domain; Region: DnaA_N; pfam11638 74546001672 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 74546001673 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 74546001674 Walker A motif; other site 74546001675 ATP binding site [chemical binding]; other site 74546001676 Walker B motif; other site 74546001677 arginine finger; other site 74546001678 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 74546001679 DnaA box-binding interface [nucleotide binding]; other site 74546001680 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 74546001681 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 74546001682 C-terminal domain interface [polypeptide binding]; other site 74546001683 GSH binding site (G-site) [chemical binding]; other site 74546001684 dimer interface [polypeptide binding]; other site 74546001685 glutathione reductase; Validated; Region: PRK06116 74546001686 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 74546001687 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 74546001688 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 74546001689 K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367 74546001690 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 74546001691 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 74546001692 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 74546001693 active site 74546001694 substrate binding pocket [chemical binding]; other site 74546001695 dimer interface [polypeptide binding]; other site 74546001696 NADH dehydrogenase transmembrane subunit; Region: NdhL; pfam10716 74546001697 Protein of unknown function (DUF3007); Region: DUF3007; pfam11460 74546001698 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 74546001699 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 74546001700 substrate binding site [chemical binding]; other site 74546001701 active site 74546001702 catalytic residues [active] 74546001703 heterodimer interface [polypeptide binding]; other site 74546001704 AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250 74546001705 YciI-like protein; Reviewed; Region: PRK12864 74546001706 Uncharacterized conserved protein [Function unknown]; Region: COG3339 74546001707 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 74546001708 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 74546001709 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 74546001710 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 74546001711 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 74546001712 DNA binding residues [nucleotide binding] 74546001713 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 74546001714 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 74546001715 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 74546001716 metal binding site [ion binding]; metal-binding site 74546001717 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 74546001718 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 74546001719 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 74546001720 Walker A motif; other site 74546001721 ATP binding site [chemical binding]; other site 74546001722 Walker B motif; other site 74546001723 arginine finger; other site 74546001724 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 74546001725 Walker A motif; other site 74546001726 ATP binding site [chemical binding]; other site 74546001727 Walker B motif; other site 74546001728 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 74546001729 plastocyanin; Provisional; Region: PRK02710 74546001730 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 74546001731 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 74546001732 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 74546001733 NAD(P) binding site [chemical binding]; other site 74546001734 active site 74546001735 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 74546001736 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 74546001737 substrate binding site [chemical binding]; other site 74546001738 active site 74546001739 glycogen branching enzyme; Provisional; Region: PRK05402 74546001740 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 74546001741 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 74546001742 active site 74546001743 catalytic site [active] 74546001744 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 74546001745 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 74546001746 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 74546001747 Domain of unknown function (DUF4332); Region: DUF4332; pfam14229 74546001748 Protein of function (DUF2518); Region: DUF2518; pfam10726 74546001749 Family of unknown function (DUF490); Region: DUF490; pfam04357 74546001750 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 74546001751 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 74546001752 putative catalytic cysteine [active] 74546001753 Dihydroneopterin aldolase; Region: FolB; smart00905 74546001754 active site 74546001755 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 74546001756 Lipase (class 2); Region: Lipase_2; pfam01674 74546001757 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 74546001758 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 74546001759 active site 74546001760 Zn binding site [ion binding]; other site 74546001761 NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK12561 74546001762 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 74546001763 homoserine kinase; Provisional; Region: PRK01212 74546001764 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 74546001765 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 74546001766 glucokinase, proteobacterial type; Region: glk; TIGR00749 74546001767 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 74546001768 nucleotide binding site [chemical binding]; other site 74546001769 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 74546001770 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 74546001771 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 74546001772 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 74546001773 active site 74546001774 dimer interface [polypeptide binding]; other site 74546001775 motif 1; other site 74546001776 motif 2; other site 74546001777 motif 3; other site 74546001778 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 74546001779 anticodon binding site; other site 74546001780 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 74546001781 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 74546001782 active site 74546001783 HIGH motif; other site 74546001784 dimer interface [polypeptide binding]; other site 74546001785 KMSKS motif; other site 74546001786 Domain of unknown function (DUF697); Region: DUF697; pfam05128 74546001787 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 74546001788 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 74546001789 metal binding site [ion binding]; metal-binding site 74546001790 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 74546001791 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 74546001792 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 74546001793 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 74546001794 ABC-ATPase subunit interface; other site 74546001795 dimer interface [polypeptide binding]; other site 74546001796 putative PBP binding regions; other site 74546001797 Domain of unknown function (DUF4336); Region: DUF4336; pfam14234 74546001798 Protein of unknown function (DUF760); Region: DUF760; pfam05542 74546001799 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 74546001800 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 74546001801 Catalytic site [active] 74546001802 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase; Region: menD; TIGR00173 74546001803 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 74546001804 dimer interface [polypeptide binding]; other site 74546001805 tetramer interface [polypeptide binding]; other site 74546001806 PYR/PP interface [polypeptide binding]; other site 74546001807 TPP binding site [chemical binding]; other site 74546001808 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 74546001809 TPP-binding site [chemical binding]; other site 74546001810 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 74546001811 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 74546001812 substrate binding site [chemical binding]; other site 74546001813 oxyanion hole (OAH) forming residues; other site 74546001814 trimer interface [polypeptide binding]; other site 74546001815 glycogen synthase; Provisional; Region: glgA; PRK00654 74546001816 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 74546001817 ADP-binding pocket [chemical binding]; other site 74546001818 homodimer interface [polypeptide binding]; other site 74546001819 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 74546001820 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 74546001821 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 74546001822 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14360 74546001823 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 74546001824 Substrate binding site; other site 74546001825 Mg++ binding site; other site 74546001826 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 74546001827 active site 74546001828 substrate binding site [chemical binding]; other site 74546001829 CoA binding site [chemical binding]; other site 74546001830 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 74546001831 S-adenosylmethionine binding site [chemical binding]; other site 74546001832 S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; cl17711 74546001833 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 74546001834 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 74546001835 hinge; other site 74546001836 active site 74546001837 2-phosphosulfolactate phosphatase; Provisional; Region: PRK00886 74546001838 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 74546001839 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 74546001840 nitrilase; Region: PLN02798 74546001841 putative active site [active] 74546001842 catalytic triad [active] 74546001843 dimer interface [polypeptide binding]; other site 74546001844 AMIN domain; Region: AMIN; pfam11741 74546001845 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 74546001846 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 74546001847 active site 74546001848 metal binding site [ion binding]; metal-binding site 74546001849 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 74546001850 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 74546001851 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 74546001852 substrate binding pocket [chemical binding]; other site 74546001853 chain length determination region; other site 74546001854 substrate-Mg2+ binding site; other site 74546001855 catalytic residues [active] 74546001856 aspartate-rich region 1; other site 74546001857 active site lid residues [active] 74546001858 aspartate-rich region 2; other site 74546001859 acetyl-CoA synthetase; Provisional; Region: PRK00174 74546001860 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 74546001861 active site 74546001862 CoA binding site [chemical binding]; other site 74546001863 acyl-activating enzyme (AAE) consensus motif; other site 74546001864 AMP binding site [chemical binding]; other site 74546001865 acetate binding site [chemical binding]; other site 74546001866 Protein of unknown function (DUF1350); Region: DUF1350; pfam07082 74546001867 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 74546001868 active site 74546001869 catalytic site [active] 74546001870 substrate binding site [chemical binding]; other site 74546001871 GLTT repeat (6 copies); Region: GLTT; pfam01744 74546001872 GLTT repeat (6 copies); Region: GLTT; pfam01744 74546001873 Protein of unknown function; Region: DUF3721; pfam12518 74546001874 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 74546001875 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 74546001876 dimer interface [polypeptide binding]; other site 74546001877 motif 1; other site 74546001878 active site 74546001879 motif 2; other site 74546001880 motif 3; other site 74546001881 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 74546001882 anticodon binding site; other site 74546001883 Tryptophan-rich protein (DUF2389); Region: DUF2389; cl09726 74546001884 chlorophyll a/b binding light-harvesting protein; Region: PS_antenn_a_b; TIGR03041 74546001885 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 74546001886 GST_N family, Omega-like subfamily; composed of uncharacterized proteins with similarity to class Omega GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_Omega_like; cd03060 74546001887 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 74546001888 putative GSH binding site (G-site) [chemical binding]; other site 74546001889 active site cysteine [active] 74546001890 putative C-terminal domain interface [polypeptide binding]; other site 74546001891 putative dimer interface [polypeptide binding]; other site 74546001892 C-terminal, alpha helical domain of an unknown subfamily 5 of Glutathione S-transferases; Region: GST_C_5; cd03196 74546001893 putative N-terminal domain interface [polypeptide binding]; other site 74546001894 putative dimer interface [polypeptide binding]; other site 74546001895 putative substrate binding pocket (H-site) [chemical binding]; other site 74546001896 T5orf172 domain; Region: T5orf172; pfam10544 74546001897 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 74546001898 short chain dehydrogenase; Provisional; Region: PRK07326 74546001899 NAD(P) binding site [chemical binding]; other site 74546001900 active site 74546001901 lycopene cyclase family protein; Region: carotene-cycl; TIGR01790 74546001902 lycopene cyclase; Region: lycopene_cycl; TIGR01789 74546001903 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 74546001904 protochlorophyllide reductase; Region: PLN00015 74546001905 NAD(P) binding site [chemical binding]; other site 74546001906 active site 74546001907 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 74546001908 Mechanosensitive ion channel; Region: MS_channel; pfam00924 74546001909 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 74546001910 Isochorismatase family; Region: Isochorismatase; pfam00857 74546001911 catalytic triad [active] 74546001912 dimer interface [polypeptide binding]; other site 74546001913 conserved cis-peptide bond; other site 74546001914 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 74546001915 metal binding site 2 [ion binding]; metal-binding site 74546001916 putative DNA binding helix; other site 74546001917 metal binding site 1 [ion binding]; metal-binding site 74546001918 dimer interface [polypeptide binding]; other site 74546001919 structural Zn2+ binding site [ion binding]; other site 74546001920 radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167 74546001921 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 74546001922 FeS/SAM binding site; other site 74546001923 Protein of unknown function (DUF3641); Region: DUF3641; pfam12345 74546001924 glucosylglycerol 3-phosphatase; Region: salt_tol_Pase; TIGR02399 74546001925 Glucosylglycerol-phosphate phosphatase (Salt_tol_Pase); Region: Salt_tol_Pase; pfam09506 74546001926 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 74546001927 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 74546001928 homodimer interface [polypeptide binding]; other site 74546001929 substrate-cofactor binding pocket; other site 74546001930 pyridoxal 5'-phosphate binding site [chemical binding]; other site 74546001931 catalytic residue [active] 74546001932 Homoserine O-succinyltransferase; Region: HTS; pfam04204 74546001933 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 74546001934 conserved cys residue [active] 74546001935 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 74546001936 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 74546001937 Sulfate transporter family; Region: Sulfate_transp; pfam00916 74546001938 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 74546001939 FAD binding domain; Region: FAD_binding_4; pfam01565 74546001940 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 74546001941 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 74546001942 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 74546001943 putative active site [active] 74546001944 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 74546001945 putative active site [active] 74546001946 Protein of unknown function (DUF2811); Region: DUF2811; pfam10929 74546001947 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 74546001948 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 74546001949 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 74546001950 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 74546001951 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 74546001952 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 74546001953 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 74546001954 dimer interface [polypeptide binding]; other site 74546001955 active site 74546001956 metal binding site [ion binding]; metal-binding site 74546001957 glutathione binding site [chemical binding]; other site 74546001958 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 74546001959 Protein of unknown function (DUF1662); Region: DUF1662; pfam07878 74546001960 ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent; Region: RTPR; TIGR02505 74546001961 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 74546001962 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 74546001963 S-adenosylmethionine binding site [chemical binding]; other site 74546001964 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 74546001965 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 74546001966 G1 box; other site 74546001967 putative GEF interaction site [polypeptide binding]; other site 74546001968 GTP/Mg2+ binding site [chemical binding]; other site 74546001969 Switch I region; other site 74546001970 G2 box; other site 74546001971 G3 box; other site 74546001972 Switch II region; other site 74546001973 G4 box; other site 74546001974 G5 box; other site 74546001975 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 74546001976 Protein of unknown function (DUF3353); Region: DUF3353; pfam11833 74546001977 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 74546001978 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 74546001979 dimerization interface [polypeptide binding]; other site 74546001980 domain crossover interface; other site 74546001981 redox-dependent activation switch; other site 74546001982 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 74546001983 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 74546001984 Walker A/P-loop; other site 74546001985 ATP binding site [chemical binding]; other site 74546001986 Q-loop/lid; other site 74546001987 ABC transporter signature motif; other site 74546001988 Walker B; other site 74546001989 D-loop; other site 74546001990 H-loop/switch region; other site 74546001991 Protein of unknown function (DUF3531); Region: DUF3531; pfam12049 74546001992 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 74546001993 RNA methyltransferase, RsmE family; Region: TIGR00046 74546001994 Integral membrane protein DUF92; Region: DUF92; pfam01940 74546001995 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_3; cd01835 74546001996 active site 74546001997 catalytic triad [active] 74546001998 oxyanion hole [active] 74546001999 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 74546002000 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 74546002001 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 74546002002 Walker A/P-loop; other site 74546002003 ATP binding site [chemical binding]; other site 74546002004 Q-loop/lid; other site 74546002005 ABC transporter signature motif; other site 74546002006 Walker B; other site 74546002007 D-loop; other site 74546002008 H-loop/switch region; other site 74546002009 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 74546002010 aspartate aminotransferase; Provisional; Region: PRK05764 74546002011 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 74546002012 pyridoxal 5'-phosphate binding site [chemical binding]; other site 74546002013 homodimer interface [polypeptide binding]; other site 74546002014 catalytic residue [active] 74546002015 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 74546002016 active site 74546002017 Fe-S cluster binding site [ion binding]; other site 74546002018 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 74546002019 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 74546002020 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 74546002021 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 74546002022 C-terminal peptidase (prc); Region: prc; TIGR00225 74546002023 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 74546002024 protein binding site [polypeptide binding]; other site 74546002025 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 74546002026 Catalytic dyad [active] 74546002027 quinolinate synthetase; Provisional; Region: PRK09375 74546002028 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 74546002029 TIGR04168 family protein; Region: TIGR04168 74546002030 Repair protein; Region: Repair_PSII; pfam04536 74546002031 Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636 74546002032 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 74546002033 active site 74546002034 dimer interface [polypeptide binding]; other site 74546002035 metal binding site [ion binding]; metal-binding site 74546002036 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 74546002037 ATP-grasp domain; Region: ATP-grasp; pfam02222 74546002038 septation ring formation regulator EzrA; Provisional; Region: PRK04778 74546002039 putative high light inducible protein; Region: PHA02337 74546002040 putative high light inducible protein; Region: PHA02337 74546002041 putative high light inducible protein; Region: PHA02337 74546002042 RmuC family; Region: RmuC; pfam02646 74546002043 Protein of unknown function (DUF1651); Region: DUF1651; pfam07864 74546002044 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 74546002045 nucleotide binding pocket [chemical binding]; other site 74546002046 K-X-D-G motif; other site 74546002047 catalytic site [active] 74546002048 Protein of unknown function (DUF1651); Region: DUF1651; pfam07864 74546002049 Chlorophyll A-B binding protein; Region: Chloroa_b-bind; pfam00504 74546002050 Tryptophan-rich protein (DUF2389); Region: DUF2389; pfam09493 74546002051 C factor cell-cell signaling protein; Provisional; Region: PRK09009 74546002052 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 74546002053 NADP binding site [chemical binding]; other site 74546002054 homodimer interface [polypeptide binding]; other site 74546002055 active site 74546002056 Y-family of DNA polymerases; Region: PolY; cl12025 74546002057 Protein of unknown function (DUF3303); Region: DUF3303; pfam11746 74546002058 Protein of unknown function (DUF1499); Region: DUF1499; pfam07386 74546002059 Ion channel; Region: Ion_trans_2; pfam07885 74546002060 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 74546002061 TrkA-N domain; Region: TrkA_N; pfam02254 74546002062 TrkA-C domain; Region: TrkA_C; pfam02080 74546002063 Cytochrome c; Region: Cytochrom_C; cl11414 74546002064 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 74546002065 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 74546002066 active site 74546002067 phosphorylation site [posttranslational modification] 74546002068 intermolecular recognition site; other site 74546002069 dimerization interface [polypeptide binding]; other site 74546002070 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 74546002071 DNA binding site [nucleotide binding] 74546002072 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 74546002073 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 74546002074 dimer interface [polypeptide binding]; other site 74546002075 phosphorylation site [posttranslational modification] 74546002076 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 74546002077 ATP binding site [chemical binding]; other site 74546002078 Mg2+ binding site [ion binding]; other site 74546002079 G-X-G motif; other site 74546002080 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 74546002081 SdiA-regulated; Region: SdiA-regulated; cd09971 74546002082 Gram-negative porin; Region: Porin_4; pfam13609 74546002083 PBP superfamily domain; Region: PBP_like_2; cl17296 74546002084 Chromate transporter; Region: Chromate_transp; pfam02417 74546002085 Chromate transporter; Region: Chromate_transp; pfam02417 74546002086 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 74546002087 putative substrate translocation pore; other site 74546002088 Major Facilitator Superfamily; Region: MFS_1; pfam07690 74546002089 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK08955 74546002090 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 74546002091 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 74546002092 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 74546002093 putative DNA binding site [nucleotide binding]; other site 74546002094 dimerization interface [polypeptide binding]; other site 74546002095 putative Zn2+ binding site [ion binding]; other site 74546002096 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 74546002097 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 74546002098 dimer interface [polypeptide binding]; other site 74546002099 conserved gate region; other site 74546002100 putative PBP binding loops; other site 74546002101 ABC-ATPase subunit interface; other site 74546002102 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 74546002103 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 74546002104 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 74546002105 dimer interface [polypeptide binding]; other site 74546002106 conserved gate region; other site 74546002107 putative PBP binding loops; other site 74546002108 ABC-ATPase subunit interface; other site 74546002109 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14259 74546002110 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 74546002111 Walker A/P-loop; other site 74546002112 ATP binding site [chemical binding]; other site 74546002113 Q-loop/lid; other site 74546002114 ABC transporter signature motif; other site 74546002115 Walker B; other site 74546002116 D-loop; other site 74546002117 H-loop/switch region; other site 74546002118 Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391 74546002119 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 74546002120 putative active site [active] 74546002121 putative metal binding site [ion binding]; other site 74546002122 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 74546002123 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 74546002124 ATP binding site [chemical binding]; other site 74546002125 putative Mg++ binding site [ion binding]; other site 74546002126 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 74546002127 nucleotide binding region [chemical binding]; other site 74546002128 ATP-binding site [chemical binding]; other site 74546002129 DEAD/H associated; Region: DEAD_assoc; pfam08494 74546002130 ATP-dependent DNA ligase; Validated; Region: PRK09247 74546002131 Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897 74546002132 active site 74546002133 DNA binding site [nucleotide binding] 74546002134 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 74546002135 DNA binding site [nucleotide binding] 74546002136 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 74546002137 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 74546002138 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 74546002139 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 74546002140 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 74546002141 Predicted metal-binding protein (DUF2103); Region: DUF2103; cl01651 74546002142 cytochrome b6-f complex subunit PetN; Provisional; Region: petN; PRK02529 74546002143 Thf1-like protein; Reviewed; Region: PRK13266 74546002144 photosystem II biogenesis protein Psp29; Region: PS_II_psb29; TIGR03060 74546002145 Clp protease; Region: CLP_protease; pfam00574 74546002146 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 74546002147 oligomer interface [polypeptide binding]; other site 74546002148 active site residues [active] 74546002149 cell division protein; Validated; Region: ftsH; CHL00176 74546002150 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 74546002151 Walker A motif; other site 74546002152 ATP binding site [chemical binding]; other site 74546002153 Walker B motif; other site 74546002154 arginine finger; other site 74546002155 Peptidase family M41; Region: Peptidase_M41; pfam01434 74546002156 Protein of unknown function (DUF3148); Region: DUF3148; pfam11347 74546002157 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 74546002158 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 74546002159 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 74546002160 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 74546002161 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 74546002162 phycocyanobilin:ferredoxin oxidoreductase; Validated; Region: PRK02816 74546002163 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 74546002164 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 74546002165 HlyD family secretion protein; Region: HlyD_3; pfam13437 74546002166 DevC protein; Region: devC; TIGR01185 74546002167 FtsX-like permease family; Region: FtsX; pfam02687 74546002168 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 74546002169 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 74546002170 Walker A/P-loop; other site 74546002171 ATP binding site [chemical binding]; other site 74546002172 Q-loop/lid; other site 74546002173 ABC transporter signature motif; other site 74546002174 Walker B; other site 74546002175 D-loop; other site 74546002176 H-loop/switch region; other site 74546002177 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 74546002178 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 74546002179 active site 74546002180 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 74546002181 rRNA interaction site [nucleotide binding]; other site 74546002182 S8 interaction site; other site 74546002183 putative laminin-1 binding site; other site 74546002184 elongation factor Ts; Reviewed; Region: tsf; PRK12332 74546002185 UBA/TS-N domain; Region: UBA; pfam00627 74546002186 Elongation factor TS; Region: EF_TS; pfam00889 74546002187 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 74546002188 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 74546002189 generic binding surface II; other site 74546002190 ssDNA binding site; other site 74546002191 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 74546002192 ATP binding site [chemical binding]; other site 74546002193 putative Mg++ binding site [ion binding]; other site 74546002194 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 74546002195 nucleotide binding region [chemical binding]; other site 74546002196 ATP-binding site [chemical binding]; other site 74546002197 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 74546002198 sulfite reductase subunit beta; Provisional; Region: PRK13504 74546002199 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 74546002200 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 74546002201 Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092 74546002202 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 74546002203 geranylgeranyl reductase; Region: ChlP; TIGR02028 74546002204 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 74546002205 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 74546002206 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 74546002207 G1 box; other site 74546002208 putative GEF interaction site [polypeptide binding]; other site 74546002209 GTP/Mg2+ binding site [chemical binding]; other site 74546002210 Switch I region; other site 74546002211 G2 box; other site 74546002212 G3 box; other site 74546002213 Switch II region; other site 74546002214 G4 box; other site 74546002215 G5 box; other site 74546002216 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 74546002217 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 74546002218 Domain of unknown function (DUF309); Region: DUF309; pfam03745 74546002219 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 74546002220 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 74546002221 Walker A/P-loop; other site 74546002222 ATP binding site [chemical binding]; other site 74546002223 Q-loop/lid; other site 74546002224 ABC transporter signature motif; other site 74546002225 Walker B; other site 74546002226 D-loop; other site 74546002227 H-loop/switch region; other site 74546002228 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 74546002229 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 74546002230 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 74546002231 substrate binding site [chemical binding]; other site 74546002232 hexamer interface [polypeptide binding]; other site 74546002233 metal binding site [ion binding]; metal-binding site 74546002234 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 74546002235 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 74546002236 putative active site [active] 74546002237 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 74546002238 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 74546002239 tRNA; other site 74546002240 putative tRNA binding site [nucleotide binding]; other site 74546002241 putative NADP binding site [chemical binding]; other site 74546002242 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 74546002243 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862 74546002244 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 74546002245 ligand binding site; other site 74546002246 oligomer interface; other site 74546002247 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 74546002248 dimer interface [polypeptide binding]; other site 74546002249 N-terminal domain interface [polypeptide binding]; other site 74546002250 sulfate 1 binding site; other site 74546002251 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 74546002252 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 74546002253 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 74546002254 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 74546002255 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 74546002256 putative active site [active] 74546002257 Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547 74546002258 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 74546002259 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 74546002260 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 74546002261 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 74546002262 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 74546002263 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 74546002264 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 74546002265 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 74546002266 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 74546002267 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 74546002268 putative active site [active] 74546002269 catalytic triad [active] 74546002270 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 74546002271 intersubunit interface [polypeptide binding]; other site 74546002272 active site 74546002273 zinc binding site [ion binding]; other site 74546002274 Na+ binding site [ion binding]; other site 74546002275 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 74546002276 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 74546002277 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 74546002278 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 74546002279 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 74546002280 Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029 74546002281 active site 74546002282 tartrate dehydrogenase; Region: TTC; TIGR02089 74546002283 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 74546002284 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 74546002285 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 74546002286 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 74546002287 trimer interface [polypeptide binding]; other site 74546002288 active site 74546002289 UDP-GlcNAc binding site [chemical binding]; other site 74546002290 lipid binding site [chemical binding]; lipid-binding site 74546002291 gamma-glutamyl kinase; Provisional; Region: PRK05429 74546002292 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 74546002293 nucleotide binding site [chemical binding]; other site 74546002294 homotetrameric interface [polypeptide binding]; other site 74546002295 putative phosphate binding site [ion binding]; other site 74546002296 putative allosteric binding site; other site 74546002297 PUA domain; Region: PUA; pfam01472 74546002298 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 74546002299 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 74546002300 active site 74546002301 motif I; other site 74546002302 motif II; other site 74546002303 Protein of unknown function (DUF3727); Region: DUF3727; pfam12527 74546002304 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 74546002305 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 74546002306 Protein of unknown function (DUF3685); Region: DUF3685; pfam12452 74546002307 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 74546002308 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 74546002309 catalytic residues [active] 74546002310 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 74546002311 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 74546002312 NAD(P) binding site [chemical binding]; other site 74546002313 active site 74546002314 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 74546002315 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 74546002316 trimer interface [polypeptide binding]; other site 74546002317 putative Zn binding site [ion binding]; other site 74546002318 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 74546002319 GSH binding site [chemical binding]; other site 74546002320 catalytic residues [active] 74546002321 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 74546002322 NADH(P)-binding; Region: NAD_binding_10; pfam13460 74546002323 NAD(P) binding site [chemical binding]; other site 74546002324 putative active site [active] 74546002325 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 74546002326 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 74546002327 minor groove reading motif; other site 74546002328 helix-hairpin-helix signature motif; other site 74546002329 substrate binding pocket [chemical binding]; other site 74546002330 active site 74546002331 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 74546002332 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 74546002333 Walker A/P-loop; other site 74546002334 ATP binding site [chemical binding]; other site 74546002335 Q-loop/lid; other site 74546002336 ABC transporter signature motif; other site 74546002337 Walker B; other site 74546002338 D-loop; other site 74546002339 H-loop/switch region; other site 74546002340 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 74546002341 Ferritin-like domain; Region: Ferritin; pfam00210 74546002342 ferroxidase diiron center [ion binding]; other site 74546002343 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 74546002344 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 74546002345 putative switch regulator; other site 74546002346 non-specific DNA interactions [nucleotide binding]; other site 74546002347 DNA binding site [nucleotide binding] 74546002348 sequence specific DNA binding site [nucleotide binding]; other site 74546002349 putative cAMP binding site [chemical binding]; other site 74546002350 transcription initiation factor IIB; Reviewed; Region: tfb; PRK00423 74546002351 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 74546002352 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 74546002353 Walker A/P-loop; other site 74546002354 ATP binding site [chemical binding]; other site 74546002355 Q-loop/lid; other site 74546002356 ABC transporter signature motif; other site 74546002357 Walker B; other site 74546002358 D-loop; other site 74546002359 H-loop/switch region; other site 74546002360 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 74546002361 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 74546002362 [2Fe-2S] cluster binding site [ion binding]; other site 74546002363 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 74546002364 hydrophobic ligand binding site; other site 74546002365 hypothetical protein; Provisional; Region: PRK13795 74546002366 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 74546002367 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 74546002368 Walker A/P-loop; other site 74546002369 ATP binding site [chemical binding]; other site 74546002370 Q-loop/lid; other site 74546002371 ABC transporter signature motif; other site 74546002372 Walker B; other site 74546002373 D-loop; other site 74546002374 H-loop/switch region; other site 74546002375 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 74546002376 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 74546002377 Walker A/P-loop; other site 74546002378 ATP binding site [chemical binding]; other site 74546002379 Q-loop/lid; other site 74546002380 ABC transporter signature motif; other site 74546002381 Walker B; other site 74546002382 D-loop; other site 74546002383 H-loop/switch region; other site 74546002384 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 74546002385 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 74546002386 TM-ABC transporter signature motif; other site 74546002387 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 74546002388 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 74546002389 TM-ABC transporter signature motif; other site 74546002390 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 74546002391 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 74546002392 putative ligand binding site [chemical binding]; other site 74546002393 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 74546002394 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 74546002395 UreF; Region: UreF; pfam01730 74546002396 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 74546002397 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 74546002398 dimer interface [polypeptide binding]; other site 74546002399 catalytic residues [active] 74546002400 UreD urease accessory protein; Region: UreD; pfam01774 74546002401 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 74546002402 alpha-gamma subunit interface [polypeptide binding]; other site 74546002403 beta-gamma subunit interface [polypeptide binding]; other site 74546002404 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 74546002405 alpha-beta subunit interface [polypeptide binding]; other site 74546002406 urease subunit alpha; Reviewed; Region: ureC; PRK13207 74546002407 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 74546002408 subunit interactions [polypeptide binding]; other site 74546002409 active site 74546002410 flap region; other site 74546002411 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 74546002412 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 74546002413 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 74546002414 active site 74546002415 catalytic site [active] 74546002416 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK00192 74546002417 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 74546002418 active site 74546002419 motif I; other site 74546002420 motif II; other site 74546002421 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 74546002422 active site 74546002423 Domain of unknown function (DUF1830); Region: DUF1830; pfam08865 74546002424 Bacitracin resistance protein BacA; Region: BacA; pfam02673 74546002425 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 74546002426 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 74546002427 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 74546002428 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 74546002429 Walker A/P-loop; other site 74546002430 ATP binding site [chemical binding]; other site 74546002431 Q-loop/lid; other site 74546002432 ABC transporter signature motif; other site 74546002433 Walker B; other site 74546002434 D-loop; other site 74546002435 H-loop/switch region; other site 74546002436 Protein of unknown function (DUF3288); Region: DUF3288; pfam11691 74546002437 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 74546002438 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 74546002439 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 74546002440 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 74546002441 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 74546002442 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 74546002443 catalytic site [active] 74546002444 subunit interface [polypeptide binding]; other site 74546002445 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cl00258 74546002446 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 74546002447 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 74546002448 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 74546002449 Domain of unknown function (DUF1816); Region: DUF1816; pfam08846 74546002450 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 74546002451 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 74546002452 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK07374 74546002453 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 74546002454 active site 74546002455 PHP Thumb interface [polypeptide binding]; other site 74546002456 metal binding site [ion binding]; metal-binding site 74546002457 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 74546002458 generic binding surface I; other site 74546002459 generic binding surface II; other site 74546002460 Protein of unknown function (DUF3464); Region: DUF3464; pfam11947 74546002461 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 74546002462 16S/18S rRNA binding site [nucleotide binding]; other site 74546002463 S13e-L30e interaction site [polypeptide binding]; other site 74546002464 25S rRNA binding site [nucleotide binding]; other site 74546002465 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 74546002466 RuvA N terminal domain; Region: RuvA_N; pfam01330 74546002467 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 74546002468 EamA-like transporter family; Region: EamA; pfam00892 74546002469 EamA-like transporter family; Region: EamA; pfam00892 74546002470 DNA primase; Validated; Region: dnaG; PRK05667 74546002471 CHC2 zinc finger; Region: zf-CHC2; pfam01807 74546002472 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 74546002473 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 74546002474 active site 74546002475 metal binding site [ion binding]; metal-binding site 74546002476 interdomain interaction site; other site 74546002477 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 74546002478 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 74546002479 active site 74546002480 DNA binding site [nucleotide binding] 74546002481 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 74546002482 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 74546002483 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 74546002484 Catalytic site [active] 74546002485 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 74546002486 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 74546002487 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 74546002488 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK02534 74546002489 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 74546002490 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 74546002491 Protein of unknown function (DUF3082); Region: DUF3082; pfam11282 74546002492 pyruvate dehydrogenase E1 component beta subunit; Validated; Region: odpB; CHL00144 74546002493 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 74546002494 alpha subunit interface [polypeptide binding]; other site 74546002495 TPP binding site [chemical binding]; other site 74546002496 heterodimer interface [polypeptide binding]; other site 74546002497 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 74546002498 protein-export membrane protein SecD; Region: secD; TIGR01129 74546002499 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 74546002500 protein-export membrane protein SecF; Region: 3a0501s07; TIGR00966 74546002501 Protein export membrane protein; Region: SecD_SecF; cl14618 74546002502 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 74546002503 Domain of unknown function DUF20; Region: UPF0118; pfam01594 74546002504 photosystem II reaction center protein Psb28; Provisional; Region: PRK13612 74546002505 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 74546002506 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 74546002507 active site residue [active] 74546002508 GUN4-like; Region: GUN4; pfam05419 74546002509 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 74546002510 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 74546002511 Methyltransferase domain; Region: Methyltransf_31; pfam13847 74546002512 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 74546002513 S-adenosylmethionine binding site [chemical binding]; other site 74546002514 glutamine synthetase, type I; Region: GlnA; TIGR00653 74546002515 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 74546002516 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 74546002517 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 74546002518 homodimer interface [polypeptide binding]; other site 74546002519 pyridoxal 5'-phosphate binding site [chemical binding]; other site 74546002520 catalytic residue [active] 74546002521 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 74546002522 nucleoside/Zn binding site; other site 74546002523 dimer interface [polypeptide binding]; other site 74546002524 catalytic motif [active] 74546002525 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 74546002526 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 74546002527 catalytic residue [active] 74546002528 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 74546002529 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 74546002530 G1 box; other site 74546002531 GTP/Mg2+ binding site [chemical binding]; other site 74546002532 G2 box; other site 74546002533 Switch I region; other site 74546002534 G3 box; other site 74546002535 Switch II region; other site 74546002536 G4 box; other site 74546002537 G5 box; other site 74546002538 Domain of unknown function (DUF697); Region: DUF697; pfam05128 74546002539 lipoprotein signal peptidase; Provisional; Region: PRK14792 74546002540 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 74546002541 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 74546002542 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 74546002543 FtsX-like permease family; Region: FtsX; pfam02687 74546002544 pyruvate kinase; Provisional; Region: PRK06354 74546002545 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 74546002546 domain interfaces; other site 74546002547 active site 74546002548 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700 74546002549 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 74546002550 putative metal binding site [ion binding]; other site 74546002551 YGGT family; Region: YGGT; pfam02325 74546002552 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 74546002553 threonine dehydratase; Reviewed; Region: PRK09224 74546002554 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 74546002555 tetramer interface [polypeptide binding]; other site 74546002556 pyridoxal 5'-phosphate binding site [chemical binding]; other site 74546002557 catalytic residue [active] 74546002558 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 74546002559 putative Ile/Val binding site [chemical binding]; other site 74546002560 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 74546002561 putative Ile/Val binding site [chemical binding]; other site 74546002562 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 74546002563 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 74546002564 TPP-binding site; other site 74546002565 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 74546002566 PYR/PP interface [polypeptide binding]; other site 74546002567 dimer interface [polypeptide binding]; other site 74546002568 TPP binding site [chemical binding]; other site 74546002569 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 74546002570 photosystem I reaction center subunit PsaK; Region: PS_I_psaK; TIGR03049 74546002571 Protein of unknown function (DUF3593); Region: DUF3593; pfam12159 74546002572 Protein of unknown function (DUF2499); Region: DUF2499; pfam10693 74546002573 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 74546002574 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 74546002575 catalytic triad [active] 74546002576 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 74546002577 heat shock protein 90; Provisional; Region: PRK05218 74546002578 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 74546002579 ATP binding site [chemical binding]; other site 74546002580 Mg2+ binding site [ion binding]; other site 74546002581 G-X-G motif; other site 74546002582 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 74546002583 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 74546002584 motif 1; other site 74546002585 dimer interface [polypeptide binding]; other site 74546002586 active site 74546002587 motif 2; other site 74546002588 motif 3; other site 74546002589 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 74546002590 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 74546002591 active site 74546002592 dimerization interface [polypeptide binding]; other site 74546002593 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 74546002594 catalytic loop [active] 74546002595 iron binding site [ion binding]; other site 74546002596 molecular chaperone DnaK; Provisional; Region: PRK13410 74546002597 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 74546002598 nucleotide binding site [chemical binding]; other site 74546002599 chaperone protein DnaJ; Provisional; Region: PRK14299 74546002600 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 74546002601 HSP70 interaction site [polypeptide binding]; other site 74546002602 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 74546002603 substrate binding site [polypeptide binding]; other site 74546002604 dimer interface [polypeptide binding]; other site 74546002605 Protein of unknown function (DUF3110); Region: DUF3110; pfam11360 74546002606 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 74546002607 active site 74546002608 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II/unknown domain fusion protein; Provisional; Region: PRK09319 74546002609 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 74546002610 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 74546002611 dimerization interface [polypeptide binding]; other site 74546002612 active site 74546002613 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 74546002614 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 74546002615 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 74546002616 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 74546002617 active site 74546002618 substrate binding site [chemical binding]; other site 74546002619 cosubstrate binding site; other site 74546002620 catalytic site [active] 74546002621 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14096 74546002622 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 74546002623 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 74546002624 dimer interface [polypeptide binding]; other site 74546002625 active site 74546002626 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 74546002627 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 74546002628 HIGH motif; other site 74546002629 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 74546002630 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 74546002631 active site 74546002632 KMSKS motif; other site 74546002633 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 74546002634 tRNA binding surface [nucleotide binding]; other site 74546002635 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 74546002636 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 74546002637 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 74546002638 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 74546002639 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 74546002640 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 74546002641 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 74546002642 catalytic residue [active] 74546002643 Domain of unknown function (DUF1995); Region: DUF1995; pfam09353 74546002644 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 74546002645 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 74546002646 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 74546002647 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 74546002648 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 74546002649 active site 74546002650 (T/H)XGH motif; other site 74546002651 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 74546002652 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 74546002653 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 74546002654 GIY-YIG motif/motif A; other site 74546002655 active site 74546002656 catalytic site [active] 74546002657 putative DNA binding site [nucleotide binding]; other site 74546002658 metal binding site [ion binding]; metal-binding site 74546002659 UvrB/uvrC motif; Region: UVR; pfam02151 74546002660 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 74546002661 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 74546002662 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 74546002663 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 74546002664 active site 74546002665 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 74546002666 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 74546002667 CobN/Magnesium Chelatase; Region: CobN-Mg_chel; pfam02514 74546002668 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 74546002669 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 74546002670 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 74546002671 homodimer interface [polypeptide binding]; other site 74546002672 substrate-cofactor binding pocket; other site 74546002673 catalytic residue [active] 74546002674 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 74546002675 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 74546002676 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 74546002677 substrate binding pocket [chemical binding]; other site 74546002678 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 74546002679 B12 binding site [chemical binding]; other site 74546002680 cobalt ligand [ion binding]; other site 74546002681 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 74546002682 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996 74546002683 ATP adenylyltransferase (5',5'''-P-1,P-4-tetraphosphate phosphorylase II) [Nucleotide transport and metabolism]; Region: APA2; COG4360 74546002684 ATP adenylyltransferase; Region: ATP_transf; pfam09830 74546002685 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 74546002686 HSP70 interaction site [polypeptide binding]; other site 74546002687 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 74546002688 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 74546002689 putative tRNA-binding site [nucleotide binding]; other site 74546002690 B3/4 domain; Region: B3_4; pfam03483 74546002691 tRNA synthetase B5 domain; Region: B5; smart00874 74546002692 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 74546002693 dimer interface [polypeptide binding]; other site 74546002694 motif 1; other site 74546002695 motif 3; other site 74546002696 motif 2; other site 74546002697 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 74546002698 ribosomal protein L33; Region: rpl33; CHL00104 74546002699 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 74546002700 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 74546002701 RNB domain; Region: RNB; pfam00773 74546002702 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 74546002703 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 74546002704 active site 74546002705 HIGH motif; other site 74546002706 KMSKS motif; other site 74546002707 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 74546002708 tRNA binding surface [nucleotide binding]; other site 74546002709 anticodon binding site; other site 74546002710 Protein of unknown function (DUF2930); Region: DUF2930; pfam11152 74546002711 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 74546002712 homotrimer interface [polypeptide binding]; other site 74546002713 Walker A motif; other site 74546002714 GTP binding site [chemical binding]; other site 74546002715 Walker B motif; other site 74546002716 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 74546002717 ATP-dependent Clp protease adaptor; Reviewed; Region: clpS; PRK13019 74546002718 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 74546002719 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 74546002720 dimer interface [polypeptide binding]; other site 74546002721 decamer (pentamer of dimers) interface [polypeptide binding]; other site 74546002722 catalytic triad [active] 74546002723 peroxidatic and resolving cysteines [active] 74546002724 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 74546002725 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 74546002726 Walker A motif; other site 74546002727 ATP binding site [chemical binding]; other site 74546002728 Walker B motif; other site 74546002729 arginine finger; other site 74546002730 Peptidase family M41; Region: Peptidase_M41; pfam01434 74546002731 ribosomal protein L32; Validated; Region: rpl32; CHL00152 74546002732 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 74546002733 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 74546002734 motif II; other site 74546002735 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 74546002736 Predicted membrane protein [Function unknown]; Region: COG2119 74546002737 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 74546002738 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 74546002739 Predicted membrane protein [Function unknown]; Region: COG2119 74546002740 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 74546002741 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 74546002742 RNB domain; Region: RNB; pfam00773 74546002743 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 74546002744 RNA binding site [nucleotide binding]; other site 74546002745 Protein of unknown function (DUF2996); Region: DUF2996; pfam11210 74546002746 Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047 74546002747 diiron binding motif [ion binding]; other site 74546002748 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 74546002749 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 74546002750 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 74546002751 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 74546002752 putative active site [active] 74546002753 substrate binding site [chemical binding]; other site 74546002754 putative cosubstrate binding site; other site 74546002755 catalytic site [active] 74546002756 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 74546002757 substrate binding site [chemical binding]; other site 74546002758 Integral membrane protein TerC family; Region: TerC; cl10468 74546002759 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 74546002760 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 74546002761 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 74546002762 ATP binding site [chemical binding]; other site 74546002763 putative Mg++ binding site [ion binding]; other site 74546002764 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 74546002765 nucleotide binding region [chemical binding]; other site 74546002766 ATP-binding site [chemical binding]; other site 74546002767 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 74546002768 Domain of unknown function (DUF4335); Region: DUF4335; pfam14233 74546002769 Protein of unknown function (DUF3038); Region: DUF3038; pfam11237 74546002770 Protein of unknown function (DUF2949); Region: DUF2949; pfam11165 74546002771 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984 74546002772 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 74546002773 dihydrodipicolinate reductase; Provisional; Region: PRK00048 74546002774 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 74546002775 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 74546002776 magnesium chelatase subunit H; Provisional; Region: PRK12493 74546002777 Domain of unknown function (DUF3479); Region: DUF3479; pfam11965 74546002778 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 74546002779 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 74546002780 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 74546002781 dihydropteroate synthase; Region: DHPS; TIGR01496 74546002782 substrate binding pocket [chemical binding]; other site 74546002783 dimer interface [polypeptide binding]; other site 74546002784 inhibitor binding site; inhibition site 74546002785 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 74546002786 triosephosphate isomerase; Provisional; Region: PRK14565 74546002787 substrate binding site [chemical binding]; other site 74546002788 dimer interface [polypeptide binding]; other site 74546002789 catalytic triad [active] 74546002790 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 74546002791 RNA binding surface [nucleotide binding]; other site 74546002792 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 74546002793 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 74546002794 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 74546002795 Walker A/P-loop; other site 74546002796 ATP binding site [chemical binding]; other site 74546002797 Q-loop/lid; other site 74546002798 ABC transporter signature motif; other site 74546002799 Walker B; other site 74546002800 D-loop; other site 74546002801 H-loop/switch region; other site 74546002802 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 74546002803 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 74546002804 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 74546002805 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 74546002806 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 74546002807 ATP-grasp domain; Region: ATP-grasp_4; cl17255 74546002808 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 74546002809 IMP binding site; other site 74546002810 dimer interface [polypeptide binding]; other site 74546002811 interdomain contacts; other site 74546002812 partial ornithine binding site; other site 74546002813 Protein of unknown function (DUF3318); Region: DUF3318; pfam11780 74546002814 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 74546002815 Protein of unknown function (DUF1230); Region: DUF1230; pfam06799 74546002816 L-asparaginase II; Region: Asparaginase_II; pfam06089 74546002817 Protein of unknown function (DUF2862); Region: DUF2862; pfam11061 74546002818 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 74546002819 ATP-binding cassette domain of an uncharacterized transporter similar in sequence to NatA; Region: ABC_NatA_like; cd03267 74546002820 Walker A/P-loop; other site 74546002821 ATP binding site [chemical binding]; other site 74546002822 Q-loop/lid; other site 74546002823 ABC transporter signature motif; other site 74546002824 Walker B; other site 74546002825 D-loop; other site 74546002826 H-loop/switch region; other site 74546002827 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 74546002828 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 74546002829 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 74546002830 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 74546002831 Endomembrane protein 70; Region: EMP70; pfam02990 74546002832 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 74546002833 active site 74546002834 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 74546002835 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 74546002836 active site 74546002837 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 74546002838 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 74546002839 Fingers domain of DNA polymerase lambda; Region: DNA_pol_lambd_f; pfam10391 74546002840 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 74546002841 AAA domain; Region: AAA_18; pfam13238 74546002842 active site 74546002843 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 74546002844 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 74546002845 active site pocket [active] 74546002846 oxyanion hole [active] 74546002847 catalytic triad [active] 74546002848 active site nucleophile [active] 74546002849 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 74546002850 Protein of unknown function (DUF3303); Region: DUF3303; pfam11746 74546002851 Protein of unknown function, DUF393; Region: DUF393; pfam04134 74546002852 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 74546002853 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 74546002854 aminopeptidase N; Provisional; Region: pepN; PRK14015 74546002855 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 74546002856 active site 74546002857 Zn binding site [ion binding]; other site 74546002858 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 74546002859 ATP-grasp domain; Region: ATP-grasp_4; cl17255 74546002860 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 74546002861 catalytic residues [active] 74546002862 dimer interface [polypeptide binding]; other site 74546002863 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 74546002864 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 74546002865 FMN binding site [chemical binding]; other site 74546002866 active site 74546002867 catalytic residues [active] 74546002868 substrate binding site [chemical binding]; other site 74546002869 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 74546002870 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 74546002871 active site 74546002872 MAPEG family; Region: MAPEG; pfam01124 74546002873 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 74546002874 Nitrogen fixation protein of unknown function; Region: Nif11; cl06756 74546002875 OsmC-like protein; Region: OsmC; pfam02566 74546002876 Protein of unknown function (DUF1499); Region: DUF1499; pfam07386 74546002877 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 74546002878 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 74546002879 dimer interface [polypeptide binding]; other site 74546002880 putative PBP binding regions; other site 74546002881 ABC-ATPase subunit interface; other site 74546002882 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 74546002883 metal binding site 2 [ion binding]; metal-binding site 74546002884 putative DNA binding helix; other site 74546002885 metal binding site 1 [ion binding]; metal-binding site 74546002886 dimer interface [polypeptide binding]; other site 74546002887 structural Zn2+ binding site [ion binding]; other site 74546002888 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 74546002889 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 74546002890 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 74546002891 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 74546002892 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 74546002893 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 74546002894 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 74546002895 P-loop, Walker A motif; other site 74546002896 Base recognition motif; other site 74546002897 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 74546002898 PQQ-like domain; Region: PQQ_2; pfam13360 74546002899 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 74546002900 structural tetrad; other site 74546002901 TFIIB zinc-binding; Region: TF_Zn_Ribbon; pfam08271 74546002902 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 74546002903 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 74546002904 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 74546002905 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 74546002906 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 74546002907 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 74546002908 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 74546002909 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 74546002910 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 74546002911 Guanosine kinase-like sugar kinases. Found in bacteria and archaea, the guanosine kinase-like group is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: Guanosine_kinase_like; cd01947 74546002912 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 74546002913 substrate binding site [chemical binding]; other site 74546002914 ATP binding site [chemical binding]; other site 74546002915 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 74546002916 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 74546002917 Major Facilitator Superfamily; Region: MFS_1; pfam07690 74546002918 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 74546002919 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 74546002920 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 74546002921 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 74546002922 dimer interface [polypeptide binding]; other site 74546002923 conserved gate region; other site 74546002924 putative PBP binding loops; other site 74546002925 ABC-ATPase subunit interface; other site 74546002926 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 74546002927 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 74546002928 homoserine dehydrogenase; Provisional; Region: PRK06349 74546002929 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 74546002930 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 74546002931 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 74546002932 Fe-S metabolism associated domain; Region: SufE; cl00951 74546002933 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 74546002934 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 74546002935 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 74546002936 active site 74546002937 putative DNA-binding cleft [nucleotide binding]; other site 74546002938 dimer interface [polypeptide binding]; other site 74546002939 Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081 74546002940 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 74546002941 Walker A motif; other site 74546002942 ATP binding site [chemical binding]; other site 74546002943 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 74546002944 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 74546002945 Cytochrome c; Region: Cytochrom_C; pfam00034 74546002946 cytochrome b6-f complex subunit PetG; Reviewed; Region: petG; PRK00665 74546002947 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 74546002948 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 74546002949 S-adenosylmethionine binding site [chemical binding]; other site 74546002950 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 74546002951 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 74546002952 putative active site [active] 74546002953 oxyanion strand; other site 74546002954 catalytic triad [active] 74546002955 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 74546002956 catalytic residues [active] 74546002957 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 74546002958 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 74546002959 phosphate binding site [ion binding]; other site 74546002960 DNA gyrase subunit A; Validated; Region: PRK05560 74546002961 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 74546002962 CAP-like domain; other site 74546002963 active site 74546002964 primary dimer interface [polypeptide binding]; other site 74546002965 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 74546002966 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 74546002967 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 74546002968 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 74546002969 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 74546002970 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 74546002971 lycopene cyclase family protein; Region: carotene-cycl; TIGR01790 74546002972 lycopene cyclase; Region: lycopene_cycl; TIGR01789 74546002973 Uncharacterized conserved protein [Function unknown]; Region: COG1543 74546002974 N-terminal catalytic domain of alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792 74546002975 active site 74546002976 substrate binding site [chemical binding]; other site 74546002977 catalytic site [active] 74546002978 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 74546002979 2-isopropylmalate synthase; Validated; Region: PRK00915 74546002980 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 74546002981 active site 74546002982 catalytic residues [active] 74546002983 metal binding site [ion binding]; metal-binding site 74546002984 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 74546002985 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 74546002986 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 74546002987 Zn2+ binding site [ion binding]; other site 74546002988 Mg2+ binding site [ion binding]; other site 74546002989 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14186 74546002990 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 74546002991 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 74546002992 homodimer interface [polypeptide binding]; other site 74546002993 NADP binding site [chemical binding]; other site 74546002994 substrate binding site [chemical binding]; other site 74546002995 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 74546002996 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 74546002997 substrate binding pocket [chemical binding]; other site 74546002998 chain length determination region; other site 74546002999 substrate-Mg2+ binding site; other site 74546003000 catalytic residues [active] 74546003001 aspartate-rich region 1; other site 74546003002 active site lid residues [active] 74546003003 aspartate-rich region 2; other site 74546003004 Divergent PAP2 family; Region: DUF212; pfam02681 74546003005 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 74546003006 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 74546003007 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 74546003008 catalytic triad [active] 74546003009 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 74546003010 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 74546003011 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 74546003012 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 74546003013 ferredoxin--NADP+ reductase; Provisional; Region: PLN03116 74546003014 These ferredoxin reductases are related to the NADPH cytochrome p450 reductases (CYPOR), but lack the FAD-binding region connecting sub-domain. Ferredoxin-NADP+ reductase (FNR) is an FAD-containing enzyme that catalyzes the reversible electron transfer...; Region: CYPOR_like_FNR; cd06208 74546003015 dimerization interface [polypeptide binding]; other site 74546003016 FAD binding pocket [chemical binding]; other site 74546003017 FAD binding motif [chemical binding]; other site 74546003018 catalytic residues [active] 74546003019 NAD binding pocket [chemical binding]; other site 74546003020 phosphate binding motif [ion binding]; other site 74546003021 beta-alpha-beta structure motif; other site 74546003022 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 74546003023 hydrophobic ligand binding site; other site 74546003024 adaptive-response sensory kinase; Validated; Region: PRK09303 74546003025 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 74546003026 tetramer interface [polypeptide binding]; other site 74546003027 dimer interface [polypeptide binding]; other site 74546003028 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 74546003029 dimer interface [polypeptide binding]; other site 74546003030 phosphorylation site [posttranslational modification] 74546003031 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 74546003032 ATP binding site [chemical binding]; other site 74546003033 Mg2+ binding site [ion binding]; other site 74546003034 G-X-G motif; other site 74546003035 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02812 74546003036 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 74546003037 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 74546003038 active site 74546003039 4-alpha-glucanotransferase; Provisional; Region: PRK14508 74546003040 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 74546003041 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 74546003042 ABC1 family; Region: ABC1; cl17513 74546003043 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 74546003044 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 74546003045 catalytic residue [active] 74546003046 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 74546003047 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 74546003048 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 74546003049 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 74546003050 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 74546003051 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 74546003052 putative active site [active] 74546003053 metal binding site [ion binding]; metal-binding site 74546003054 Clp protease ATP binding subunit; Region: clpC; CHL00095 74546003055 Clp amino terminal domain; Region: Clp_N; pfam02861 74546003056 Clp amino terminal domain; Region: Clp_N; pfam02861 74546003057 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 74546003058 Walker A motif; other site 74546003059 ATP binding site [chemical binding]; other site 74546003060 Walker B motif; other site 74546003061 arginine finger; other site 74546003062 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 74546003063 Walker A motif; other site 74546003064 ATP binding site [chemical binding]; other site 74546003065 Walker B motif; other site 74546003066 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 74546003067 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 74546003068 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 74546003069 Coenzyme A binding pocket [chemical binding]; other site 74546003070 diaminopimelate decarboxylase; Region: lysA; TIGR01048 74546003071 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 74546003072 active site 74546003073 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 74546003074 substrate binding site [chemical binding]; other site 74546003075 catalytic residues [active] 74546003076 dimer interface [polypeptide binding]; other site 74546003077 TIGR00159 family protein; Region: TIGR00159 74546003078 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 74546003079 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 74546003080 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 74546003081 catalytic residue [active] 74546003082 putative FPP diphosphate binding site; other site 74546003083 putative FPP binding hydrophobic cleft; other site 74546003084 dimer interface [polypeptide binding]; other site 74546003085 putative IPP diphosphate binding site; other site 74546003086 biotin synthase; Region: bioB; TIGR00433 74546003087 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 74546003088 FeS/SAM binding site; other site 74546003089 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 74546003090 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 74546003091 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 74546003092 active site residue [active] 74546003093 lipoyl synthase; Provisional; Region: PRK12928 74546003094 recombination protein RecR; Reviewed; Region: recR; PRK00076 74546003095 RecR protein; Region: RecR; pfam02132 74546003096 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 74546003097 putative active site [active] 74546003098 putative metal-binding site [ion binding]; other site 74546003099 tetramer interface [polypeptide binding]; other site 74546003100 PsbP; Region: PsbP; pfam01789 74546003101 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 74546003102 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 74546003103 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 74546003104 Walker A/P-loop; other site 74546003105 ATP binding site [chemical binding]; other site 74546003106 Q-loop/lid; other site 74546003107 ABC transporter signature motif; other site 74546003108 Walker B; other site 74546003109 D-loop; other site 74546003110 H-loop/switch region; other site 74546003111 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 74546003112 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 74546003113 ATP binding site [chemical binding]; other site 74546003114 Mg++ binding site [ion binding]; other site 74546003115 motif III; other site 74546003116 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 74546003117 nucleotide binding region [chemical binding]; other site 74546003118 ATP-binding site [chemical binding]; other site 74546003119 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 74546003120 AAA domain; Region: AAA_30; pfam13604 74546003121 Family description; Region: UvrD_C_2; pfam13538 74546003122 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 74546003123 UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361 74546003124 Phospholipid methyltransferase; Region: PEMT; cl17370 74546003125 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 74546003126 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 74546003127 Protein of unknown function (DUF2488); Region: Ycf54; pfam10674 74546003128 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 74546003129 active site 74546003130 hydrophilic channel; other site 74546003131 dimerization interface [polypeptide binding]; other site 74546003132 catalytic residues [active] 74546003133 active site lid [active] 74546003134 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 74546003135 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 74546003136 putative acyl-acceptor binding pocket; other site 74546003137 BolA-like protein; Region: BolA; pfam01722 74546003138 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 74546003139 putative GSH binding site [chemical binding]; other site 74546003140 catalytic residues [active] 74546003141 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 74546003142 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 74546003143 active site 74546003144 intermolecular recognition site; other site 74546003145 dimerization interface [polypeptide binding]; other site 74546003146 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 74546003147 DNA binding site [nucleotide binding] 74546003148 carotene isomerase; Region: carot_isom; TIGR02730 74546003149 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 74546003150 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 74546003151 Glucose inhibited division protein A; Region: GIDA; pfam01134 74546003152 photosystem II protein Y; Reviewed; Region: pbsY; PRK13240 74546003153 putative high light inducible protein; Region: PHA02337 74546003154 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 74546003155 active site 74546003156 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 74546003157 HSP70 interaction site [polypeptide binding]; other site 74546003158 Protein of unknown function (DUF1651); Region: DUF1651; pfam07864 74546003159 putative high light inducible protein; Region: PHA02337 74546003160 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 74546003161 protein I interface; other site 74546003162 D2 interface; other site 74546003163 protein T interface; other site 74546003164 chlorophyll binding site; other site 74546003165 beta carotene binding site; other site 74546003166 pheophytin binding site; other site 74546003167 manganese-stabilizing polypeptide interface; other site 74546003168 CP43 interface; other site 74546003169 protein L interface; other site 74546003170 oxygen evolving complex binding site; other site 74546003171 bromide binding site; other site 74546003172 quinone binding site; other site 74546003173 Fe binding site [ion binding]; other site 74546003174 core light harvesting interface; other site 74546003175 cytochrome b559 alpha subunit interface; other site 74546003176 cytochrome c-550 interface; other site 74546003177 protein J interface; other site 74546003178 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 74546003179 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 74546003180 putative active site [active] 74546003181 putative NTP binding site [chemical binding]; other site 74546003182 putative nucleic acid binding site [nucleotide binding]; other site 74546003183 leucyl-tRNA synthetase; Reviewed; Region: leuS; PRK12300 74546003184 WGR domain of bacterial DNA ligases; Region: WGR_DNA_ligase; cd07998 74546003185 Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cd06846 74546003186 active site 74546003187 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 74546003188 Methyltransferase domain; Region: Methyltransf_24; pfam13578 74546003189 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 74546003190 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 74546003191 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 74546003192 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 74546003193 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 74546003194 Walker A/P-loop; other site 74546003195 ATP binding site [chemical binding]; other site 74546003196 Q-loop/lid; other site 74546003197 ABC transporter signature motif; other site 74546003198 Walker B; other site 74546003199 D-loop; other site 74546003200 H-loop/switch region; other site 74546003201 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 74546003202 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 74546003203 dimer interface [polypeptide binding]; other site 74546003204 conserved gate region; other site 74546003205 putative PBP binding loops; other site 74546003206 ABC-ATPase subunit interface; other site 74546003207 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 74546003208 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 74546003209 dimer interface [polypeptide binding]; other site 74546003210 conserved gate region; other site 74546003211 putative PBP binding loops; other site 74546003212 ABC-ATPase subunit interface; other site 74546003213 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 74546003214 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 74546003215 substrate binding pocket [chemical binding]; other site 74546003216 membrane-bound complex binding site; other site 74546003217 hinge residues; other site 74546003218 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 74546003219 NmrA-like family; Region: NmrA; pfam05368 74546003220 NADP binding site [chemical binding]; other site 74546003221 active site 74546003222 regulatory binding site [polypeptide binding]; other site 74546003223 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 74546003224 putative amphipathic alpha helix; other site 74546003225 Sugar transport protein; Region: Sugar_transport; pfam06800 74546003226 Protein of unknown function (DUF1651); Region: DUF1651; pfam07864 74546003227 Chlorophyll A-B binding protein; Region: Chloroa_b-bind; cl02879 74546003228 cytochrome b559 subunit beta; Provisional; Region: psbF; PRK02561 74546003229 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 74546003230 Outer membrane efflux protein; Region: OEP; pfam02321 74546003231 Outer membrane efflux protein; Region: OEP; pfam02321 74546003232 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 74546003233 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259 74546003234 putative active site [active] 74546003235 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 74546003236 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 74546003237 Walker A/P-loop; other site 74546003238 ATP binding site [chemical binding]; other site 74546003239 Q-loop/lid; other site 74546003240 ABC transporter signature motif; other site 74546003241 Walker B; other site 74546003242 D-loop; other site 74546003243 H-loop/switch region; other site 74546003244 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 74546003245 HlyD family secretion protein; Region: HlyD_3; pfam13437 74546003246 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 74546003247 active site 74546003248 catalytic triad [active] 74546003249 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 74546003250 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 74546003251 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 74546003252 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 74546003253 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 74546003254 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 74546003255 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 74546003256 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 74546003257 Walker A motif; other site 74546003258 ATP binding site [chemical binding]; other site 74546003259 Walker B motif; other site 74546003260 Type II/IV secretion system protein; Region: T2SE; pfam00437 74546003261 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 74546003262 Walker A motif; other site 74546003263 ATP binding site [chemical binding]; other site 74546003264 Walker B motif; other site 74546003265 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 74546003266 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 74546003267 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 74546003268 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 74546003269 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 74546003270 binding surface 74546003271 TPR motif; other site 74546003272 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 74546003273 binding surface 74546003274 TPR motif; other site 74546003275 Tetratricopeptide repeat; Region: TPR_12; pfam13424 74546003276 Methyltransferase domain; Region: Methyltransf_31; pfam13847 74546003277 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 74546003278 S-adenosylmethionine binding site [chemical binding]; other site 74546003279 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 74546003280 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 74546003281 RNA binding surface [nucleotide binding]; other site 74546003282 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 74546003283 probable active site [active] 74546003284 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 74546003285 Protein of unknown function (DUF1651); Region: DUF1651; pfam07864 74546003286 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 74546003287 Protein of unknown function (DUF3303); Region: DUF3303; pfam11746 74546003288 Protein of unknown function, DUF; Region: DUF411; cl01142 74546003289 Protein of unknown function; Region: DUF3721; pfam12518 74546003290 Protein of unknown function (DUF2839); Region: DUF2839; pfam10999 74546003291 Protein of unknown function (DUF2839); Region: DUF2839; pfam10999 74546003292 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 74546003293 Protein of unknown function (DUF3764); Region: DUF3764; pfam12594 74546003294 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 74546003295 Na2 binding site [ion binding]; other site 74546003296 putative substrate binding site 1 [chemical binding]; other site 74546003297 Na binding site 1 [ion binding]; other site 74546003298 putative substrate binding site 2 [chemical binding]; other site 74546003299 Uncharacterized ACR, YdiU/UPF0061 family; Region: UPF0061; pfam02696 74546003300 hypothetical protein; Validated; Region: PRK00029 74546003301 Cupin domain; Region: Cupin_2; pfam07883 74546003302 Protein of unknown function (DUF1651); Region: DUF1651; pfam07864 74546003303 putative high light inducible protein; Region: PHA02337 74546003304 putative high light inducible protein; Region: PHA02337 74546003305 putative high light inducible protein; Region: PHA02337 74546003306 GTP-binding protein YchF; Reviewed; Region: PRK09601 74546003307 YchF GTPase; Region: YchF; cd01900 74546003308 G1 box; other site 74546003309 GTP/Mg2+ binding site [chemical binding]; other site 74546003310 Switch I region; other site 74546003311 G2 box; other site 74546003312 Switch II region; other site 74546003313 G3 box; other site 74546003314 G4 box; other site 74546003315 G5 box; other site 74546003316 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 74546003317 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 74546003318 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 74546003319 HlyD family secretion protein; Region: HlyD_3; pfam13437 74546003320 DNA polymerase I; Provisional; Region: PRK05755 74546003321 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 74546003322 active site 74546003323 metal binding site 1 [ion binding]; metal-binding site 74546003324 putative 5' ssDNA interaction site; other site 74546003325 metal binding site 3; metal-binding site 74546003326 metal binding site 2 [ion binding]; metal-binding site 74546003327 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 74546003328 putative DNA binding site [nucleotide binding]; other site 74546003329 putative metal binding site [ion binding]; other site 74546003330 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 74546003331 active site 74546003332 catalytic site [active] 74546003333 substrate binding site [chemical binding]; other site 74546003334 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 74546003335 active site 74546003336 DNA binding site [nucleotide binding] 74546003337 catalytic site [active] 74546003338 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 74546003339 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 74546003340 active site 74546003341 HIGH motif; other site 74546003342 nucleotide binding site [chemical binding]; other site 74546003343 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 74546003344 KMSKS motif; other site 74546003345 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 74546003346 tRNA binding surface [nucleotide binding]; other site 74546003347 anticodon binding site; other site 74546003348 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 74546003349 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 74546003350 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 74546003351 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 74546003352 putative high light inducible protein; Region: PHA02337 74546003353 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 74546003354 dimer interface [polypeptide binding]; other site 74546003355 [2Fe-2S] cluster binding site [ion binding]; other site 74546003356 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 74546003357 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 74546003358 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 74546003359 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 74546003360 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 74546003361 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 74546003362 ligand binding site [chemical binding]; other site 74546003363 homodimer interface [polypeptide binding]; other site 74546003364 NAD(P) binding site [chemical binding]; other site 74546003365 trimer interface B [polypeptide binding]; other site 74546003366 trimer interface A [polypeptide binding]; other site 74546003367 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 74546003368 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 74546003369 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 74546003370 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 74546003371 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 74546003372 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 74546003373 rRNA binding site [nucleotide binding]; other site 74546003374 predicted 30S ribosome binding site; other site 74546003375 Ycf39; Provisional; Region: ycf39; CHL00194 74546003376 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 74546003377 NAD(P) binding site [chemical binding]; other site 74546003378 putative active site [active] 74546003379 cytochrome b6-f complex subunit PetM; Reviewed; Region: petM; PRK11876 74546003380 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 74546003381 Lipase (class 2); Region: Lipase_2; pfam01674 74546003382 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 74546003383 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 74546003384 putative valine binding site [chemical binding]; other site 74546003385 dimer interface [polypeptide binding]; other site 74546003386 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 74546003387 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 74546003388 active site 74546003389 photosystem I assembly protein Ycf4; Provisional; Region: PRK02542 74546003390 photosystem II protein D2; Region: psbD; CHL00004 74546003391 pheophytin binding site; other site 74546003392 chlorophyll binding site; other site 74546003393 quinone binding site; other site 74546003394 Fe binding site [ion binding]; other site 74546003395 Photosystem II protein; Region: PSII; cl08223 74546003396 photosystem II 44 kDa subunit reaction center protein (also called P6 protein, CP43), bacterial and chloroplast; Region: psbC; TIGR01153 74546003397 Maf-like protein; Region: Maf; pfam02545 74546003398 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 74546003399 active site 74546003400 dimer interface [polypeptide binding]; other site 74546003401 cobyric acid synthase; Provisional; Region: PRK00784 74546003402 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 74546003403 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 74546003404 catalytic triad [active] 74546003405 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 74546003406 catalytic loop [active] 74546003407 iron binding site [ion binding]; other site 74546003408 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 74546003409 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 74546003410 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 74546003411 glycyl-tRNA synthetase subunit alpha; Validated; Region: glyQ; PRK09348 74546003412 dimer interface [polypeptide binding]; other site 74546003413 active site 74546003414 motif 2; other site 74546003415 motif 3; other site 74546003416 Domain of unknown function (DUF1824); Region: DUF1824; pfam08854 74546003417 macrophage migration inhibition factor-like protein; Provisional; Region: PTZ00397 74546003418 Methyltransferase domain; Region: Methyltransf_11; pfam08241 74546003419 Protein of unknown function (DUF3386); Region: DUF3386; pfam11866 74546003420 chlorophyll a/b binding light-harvesting protein; Region: PS_antenn_a_b; TIGR03041 74546003421 flavodoxin FldA; Validated; Region: PRK09267 74546003422 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 74546003423 Uncharacterized conserved protein [Function unknown]; Region: COG4095 74546003424 Membrane transport protein; Region: Mem_trans; cl09117 74546003425 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 74546003426 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 74546003427 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 74546003428 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 74546003429 EamA-like transporter family; Region: EamA; pfam00892 74546003430 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 74546003431 EamA-like transporter family; Region: EamA; pfam00892 74546003432 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 74546003433 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 74546003434 tandem repeat interface [polypeptide binding]; other site 74546003435 oligomer interface [polypeptide binding]; other site 74546003436 active site residues [active] 74546003437 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 74546003438 active site 74546003439 homotrimer interaction site [polypeptide binding]; other site 74546003440 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 74546003441 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 74546003442 Ribonuclease P; Region: Ribonuclease_P; cl00457 74546003443 Bacterial PH domain; Region: DUF304; pfam03703 74546003444 putative inner membrane protein translocase component YidC; Provisional; Region: PRK02654 74546003445 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 74546003446 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 74546003447 Ycf46; Provisional; Region: ycf46; CHL00195 74546003448 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 74546003449 Walker A motif; other site 74546003450 ATP binding site [chemical binding]; other site 74546003451 Walker B motif; other site 74546003452 arginine finger; other site 74546003453 seryl-tRNA synthetase; Provisional; Region: PRK05431 74546003454 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 74546003455 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 74546003456 dimer interface [polypeptide binding]; other site 74546003457 active site 74546003458 motif 1; other site 74546003459 motif 2; other site 74546003460 motif 3; other site 74546003461 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 74546003462 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 74546003463 active site 74546003464 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 74546003465 protein binding site [polypeptide binding]; other site 74546003466 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 74546003467 putative substrate binding region [chemical binding]; other site 74546003468 ribosomal protein S14; Region: rps14; CHL00074 74546003469 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 74546003470 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 74546003471 RNase E interface [polypeptide binding]; other site 74546003472 trimer interface [polypeptide binding]; other site 74546003473 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 74546003474 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 74546003475 RNase E interface [polypeptide binding]; other site 74546003476 trimer interface [polypeptide binding]; other site 74546003477 active site 74546003478 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 74546003479 putative nucleic acid binding region [nucleotide binding]; other site 74546003480 G-X-X-G motif; other site 74546003481 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 74546003482 RNA binding site [nucleotide binding]; other site 74546003483 domain interface; other site 74546003484 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 74546003485 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 74546003486 active site 74546003487 Predicted methyltransferases [General function prediction only]; Region: COG0313 74546003488 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 74546003489 putative SAM binding site [chemical binding]; other site 74546003490 putative homodimer interface [polypeptide binding]; other site 74546003491 O-Antigen ligase; Region: Wzy_C; pfam04932 74546003492 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 74546003493 putative trimer interface [polypeptide binding]; other site 74546003494 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 74546003495 putative CoA binding site [chemical binding]; other site 74546003496 putative trimer interface [polypeptide binding]; other site 74546003497 putative active site [active] 74546003498 putative substrate binding site [chemical binding]; other site 74546003499 putative CoA binding site [chemical binding]; other site 74546003500 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 74546003501 TrkA-N domain; Region: TrkA_N; pfam02254 74546003502 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 74546003503 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 74546003504 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 74546003505 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 74546003506 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 74546003507 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 74546003508 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 74546003509 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 74546003510 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 74546003511 tetramer interface [polypeptide binding]; other site 74546003512 TPP-binding site [chemical binding]; other site 74546003513 heterodimer interface [polypeptide binding]; other site 74546003514 phosphorylation loop region [posttranslational modification] 74546003515 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 74546003516 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 74546003517 PYR/PP interface [polypeptide binding]; other site 74546003518 dimer interface [polypeptide binding]; other site 74546003519 TPP binding site [chemical binding]; other site 74546003520 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 74546003521 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 74546003522 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 74546003523 inhibitor-cofactor binding pocket; inhibition site 74546003524 pyridoxal 5'-phosphate binding site [chemical binding]; other site 74546003525 catalytic residue [active] 74546003526 Bacterial sugar transferase; Region: Bac_transf; pfam02397 74546003527 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 74546003528 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 74546003529 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 74546003530 NAD(P) binding site [chemical binding]; other site 74546003531 homodimer interface [polypeptide binding]; other site 74546003532 substrate binding site [chemical binding]; other site 74546003533 active site 74546003534 Glycosyl transferase 4-like; Region: Glyco_trans_4_2; pfam13477 74546003535 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 74546003536 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 74546003537 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 74546003538 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 74546003539 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 74546003540 probable UDP-glucose 6-dehydrogenase; Region: PLN02353 74546003541 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 74546003542 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 74546003543 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 74546003544 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 74546003545 putative NAD(P) binding site [chemical binding]; other site 74546003546 active site 74546003547 putative substrate binding site [chemical binding]; other site 74546003548 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 74546003549 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 74546003550 Substrate binding site; other site 74546003551 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 74546003552 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 74546003553 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 74546003554 NADP binding site [chemical binding]; other site 74546003555 active site 74546003556 putative substrate binding site [chemical binding]; other site 74546003557 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 74546003558 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 74546003559 NADP-binding site; other site 74546003560 homotetramer interface [polypeptide binding]; other site 74546003561 substrate binding site [chemical binding]; other site 74546003562 homodimer interface [polypeptide binding]; other site 74546003563 active site 74546003564 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 74546003565 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 74546003566 NAD binding site [chemical binding]; other site 74546003567 homodimer interface [polypeptide binding]; other site 74546003568 active site 74546003569 substrate binding site [chemical binding]; other site 74546003570 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 74546003571 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 74546003572 Mg++ binding site [ion binding]; other site 74546003573 putative catalytic motif [active] 74546003574 substrate binding site [chemical binding]; other site 74546003575 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 74546003576 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 74546003577 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 74546003578 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 74546003579 putative ADP-binding pocket [chemical binding]; other site 74546003580 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 74546003581 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 74546003582 active site 74546003583 dimer interface [polypeptide binding]; other site 74546003584 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 74546003585 Ligand Binding Site [chemical binding]; other site 74546003586 Molecular Tunnel; other site 74546003587 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 74546003588 S-adenosylmethionine binding site [chemical binding]; other site 74546003589 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 74546003590 active site 74546003591 Phosphotransferase enzyme family; Region: APH; pfam01636 74546003592 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 74546003593 Cupin domain; Region: Cupin_2; cl17218 74546003594 capsule biosynthesis phosphatase; Region: EcbF-BcbF; TIGR01689 74546003595 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 74546003596 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 74546003597 ATP binding site [chemical binding]; other site 74546003598 ABC transporter; Region: ABC_tran; pfam00005 74546003599 Q-loop/lid; other site 74546003600 ABC transporter signature motif; other site 74546003601 Walker B; other site 74546003602 D-loop; other site 74546003603 H-loop/switch region; other site 74546003604 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 74546003605 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 74546003606 active site 74546003607 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 74546003608 UDP-glucose 4 epimerase, subgroup 2, extended (e) SDRs; Region: UDP_G4E_2_SDR_e; cd05234 74546003609 NAD binding site [chemical binding]; other site 74546003610 homodimer interface [polypeptide binding]; other site 74546003611 active site 74546003612 putative substrate binding site [chemical binding]; other site 74546003613 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 74546003614 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 74546003615 active site 74546003616 Substrate binding site; other site 74546003617 Mg++ binding site; other site 74546003618 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 74546003619 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 74546003620 active site 74546003621 motif I; other site 74546003622 motif II; other site 74546003623 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 74546003624 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 74546003625 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 74546003626 dimer interface [polypeptide binding]; other site 74546003627 active site 74546003628 NeuB family; Region: NeuB; pfam03102 74546003629 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 74546003630 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 74546003631 ligand binding site; other site 74546003632 tetramer interface; other site 74546003633 capsule biosynthesis phosphatase; Region: EcbF-BcbF; TIGR01689 74546003634 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 74546003635 NeuB family; Region: NeuB; pfam03102 74546003636 capsule biosynthesis phosphatase; Region: EcbF-BcbF; TIGR01689 74546003637 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 74546003638 dimer interface [polypeptide binding]; other site 74546003639 active site 74546003640 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 74546003641 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 74546003642 ligand binding site; other site 74546003643 tetramer interface; other site 74546003644 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 74546003645 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 74546003646 NAD(P) binding site [chemical binding]; other site 74546003647 active site 74546003648 Enoyl-(Acyl carrier protein) reductase; Region: adh_short_C2; pfam13561 74546003649 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 74546003650 NAD(P) binding site [chemical binding]; other site 74546003651 active site 74546003652 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 74546003653 flagellin modification protein A; Provisional; Region: PRK09186 74546003654 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 74546003655 NAD(P) binding site [chemical binding]; other site 74546003656 active site 74546003657 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK06263 74546003658 L-aspartate oxidase; Provisional; Region: PRK06175 74546003659 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 74546003660 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 74546003661 Chain length determinant protein; Region: Wzz; pfam02706 74546003662 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 74546003663 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 74546003664 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 74546003665 Catalytic site [active] 74546003666 ornithine carbamoyltransferase; Provisional; Region: PRK00779 74546003667 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 74546003668 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 74546003669 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 74546003670 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 74546003671 Walker A motif; other site 74546003672 ATP binding site [chemical binding]; other site 74546003673 Walker B motif; other site 74546003674 arginine finger; other site 74546003675 Peptidase family M41; Region: Peptidase_M41; pfam01434 74546003676 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 74546003677 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 74546003678 catalytic motif [active] 74546003679 Zn binding site [ion binding]; other site 74546003680 RibD C-terminal domain; Region: RibD_C; cl17279 74546003681 Protein of unknown function (DUF3122); Region: DUF3122; pfam11320 74546003682 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 74546003683 active site 74546003684 putative homodimer interface [polypeptide binding]; other site 74546003685 SAM binding site [chemical binding]; other site 74546003686 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 74546003687 precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; Region: CbiT; TIGR02469 74546003688 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02649 74546003689 ATP-NAD kinase; Region: NAD_kinase; pfam01513 74546003690 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 74546003691 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 74546003692 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 74546003693 dimer interface [polypeptide binding]; other site 74546003694 motif 1; other site 74546003695 active site 74546003696 motif 2; other site 74546003697 motif 3; other site 74546003698 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 74546003699 Protein of unknown function (DUF3611); Region: DUF3611; pfam12263 74546003700 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 74546003701 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 74546003702 active site 74546003703 Riboflavin kinase; Region: Flavokinase; smart00904 74546003704 thiamine-phosphate pyrophosphorylase; Provisional; Region: PRK02615 74546003705 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 74546003706 thiamine phosphate binding site [chemical binding]; other site 74546003707 active site 74546003708 pyrophosphate binding site [ion binding]; other site 74546003709 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 74546003710 thiS-thiF/thiG interaction site; other site 74546003711 AIR carboxylase; Region: AIRC; smart01001 74546003712 uncharacterized cyanobacterial protein, TIGR03792 family; Region: TIGR03792 74546003713 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 74546003714 homotrimer interaction site [polypeptide binding]; other site 74546003715 zinc binding site [ion binding]; other site 74546003716 CDP-binding sites; other site 74546003717 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 74546003718 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 74546003719 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 74546003720 GTPase Era; Reviewed; Region: era; PRK00089 74546003721 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 74546003722 G1 box; other site 74546003723 GTP/Mg2+ binding site [chemical binding]; other site 74546003724 Switch I region; other site 74546003725 G2 box; other site 74546003726 Switch II region; other site 74546003727 G3 box; other site 74546003728 G4 box; other site 74546003729 G5 box; other site 74546003730 KH domain; Region: KH_2; pfam07650 74546003731 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 74546003732 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 74546003733 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 74546003734 PhoH-like protein; Region: PhoH; pfam02562 74546003735 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 74546003736 signal recognition particle protein; Provisional; Region: PRK10867 74546003737 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 74546003738 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 74546003739 P loop; other site 74546003740 GTP binding site [chemical binding]; other site 74546003741 Signal peptide binding domain; Region: SRP_SPB; pfam02978 74546003742 DnaJ domain; Region: DnaJ; pfam00226 74546003743 Protein of unknown function (DUF4101); Region: DUF4101; pfam13355 74546003744 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 74546003745 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 74546003746 tetramer interface [polypeptide binding]; other site 74546003747 TPP-binding site [chemical binding]; other site 74546003748 heterodimer interface [polypeptide binding]; other site 74546003749 phosphorylation loop region [posttranslational modification] 74546003750 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 74546003751 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 74546003752 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 74546003753 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 74546003754 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 74546003755 DNA binding residues [nucleotide binding] 74546003756 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 74546003757 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 74546003758 putative substrate binding site [chemical binding]; other site 74546003759 putative ATP binding site [chemical binding]; other site 74546003760 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 74546003761 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 74546003762 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 74546003763 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 74546003764 putative active site [active] 74546003765 catalytic triad [active] 74546003766 putative dimer interface [polypeptide binding]; other site 74546003767 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 74546003768 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 74546003769 superoxide dismutase, Ni; Region: sodN; TIGR02753 74546003770 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 74546003771 Catalytic site [active] 74546003772 High-affinity nickel-transport protein; Region: NicO; cl00964 74546003773 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 74546003774 active site 74546003775 ribulose/triose binding site [chemical binding]; other site 74546003776 phosphate binding site [ion binding]; other site 74546003777 substrate (anthranilate) binding pocket [chemical binding]; other site 74546003778 product (indole) binding pocket [chemical binding]; other site 74546003779 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 74546003780 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 74546003781 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 74546003782 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 74546003783 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 74546003784 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 74546003785 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 74546003786 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 74546003787 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 74546003788 hinge; other site 74546003789 active site 74546003790 acetylornithine aminotransferase; Provisional; Region: PRK02627 74546003791 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 74546003792 inhibitor-cofactor binding pocket; inhibition site 74546003793 pyridoxal 5'-phosphate binding site [chemical binding]; other site 74546003794 catalytic residue [active] 74546003795 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 74546003796 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 74546003797 FAD binding domain; Region: FAD_binding_4; pfam01565 74546003798 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 74546003799 Amidohydrolase; Region: Amidohydro_4; pfam13147 74546003800 active site 74546003801 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14333 74546003802 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 74546003803 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 74546003804 FeS/SAM binding site; other site 74546003805 TRAM domain; Region: TRAM; pfam01938 74546003806 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 74546003807 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 74546003808 ATP-grasp domain; Region: ATP-grasp_4; cl17255 74546003809 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 74546003810 cell division protein FtsZ; Validated; Region: PRK09330 74546003811 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 74546003812 nucleotide binding site [chemical binding]; other site 74546003813 SulA interaction site; other site 74546003814 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 74546003815 oligomerization interface [polypeptide binding]; other site 74546003816 active site 74546003817 metal binding site [ion binding]; metal-binding site 74546003818 coproporphyrinogen III oxidase; Provisional; Region: PRK07379 74546003819 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 74546003820 FeS/SAM binding site; other site 74546003821 HemN C-terminal domain; Region: HemN_C; pfam06969 74546003822 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 74546003823 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 74546003824 putative active site [active] 74546003825 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 74546003826 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 74546003827 oligomer interface [polypeptide binding]; other site 74546003828 active site residues [active] 74546003829 Clp protease; Region: CLP_protease; pfam00574 74546003830 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 74546003831 oligomer interface [polypeptide binding]; other site 74546003832 active site residues [active] 74546003833 ketol-acid reductoisomerase; Provisional; Region: PRK05479 74546003834 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 74546003835 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 74546003836 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 74546003837 Chlorophyll A-B binding protein; Region: Chloroa_b-bind; cl02879 74546003838 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 74546003839 IHF dimer interface [polypeptide binding]; other site 74546003840 IHF - DNA interface [nucleotide binding]; other site 74546003841 Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523 74546003842 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 74546003843 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 74546003844 active site 74546003845 catalytic site [active] 74546003846 MFS/sugar transport protein; Region: MFS_2; pfam13347 74546003847 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 74546003848 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 74546003849 Permease; Region: Permease; pfam02405 74546003850 Protein of unknown function (DUF3119); Region: DUF3119; pfam11317 74546003851 Protein of unknown function (DUF3086); Region: DUF3086; pfam11285 74546003852 membrane protein; Provisional; Region: PRK14419 74546003853 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 74546003854 active site 74546003855 dimer interface [polypeptide binding]; other site 74546003856 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 74546003857 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 74546003858 active site 74546003859 HIGH motif; other site 74546003860 dimer interface [polypeptide binding]; other site 74546003861 KMSKS motif; other site 74546003862 Domain of unknown function (DUF1825); Region: DUF1825; pfam08855 74546003863 multifunctional aminopeptidase A; Provisional; Region: PRK00913 74546003864 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 74546003865 interface (dimer of trimers) [polypeptide binding]; other site 74546003866 Substrate-binding/catalytic site; other site 74546003867 Zn-binding sites [ion binding]; other site 74546003868 Peptide methionine sulfoxide reductase; Region: PMSR; pfam01625 74546003869 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 74546003870 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 74546003871 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 74546003872 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 74546003873 active site 74546003874 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 74546003875 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 74546003876 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 74546003877 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 74546003878 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 74546003879 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 74546003880 Surface antigen; Region: Bac_surface_Ag; pfam01103 74546003881 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 74546003882 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 74546003883 ATP binding site [chemical binding]; other site 74546003884 active site 74546003885 substrate binding site [chemical binding]; other site 74546003886 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 74546003887 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 74546003888 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 74546003889 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 74546003890 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 74546003891 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 74546003892 dimerization interface [polypeptide binding]; other site 74546003893 PAS domain; Region: PAS; smart00091 74546003894 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 74546003895 dimer interface [polypeptide binding]; other site 74546003896 phosphorylation site [posttranslational modification] 74546003897 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 74546003898 ATP binding site [chemical binding]; other site 74546003899 Mg2+ binding site [ion binding]; other site 74546003900 G-X-G motif; other site 74546003901 circadian clock protein KaiC; Reviewed; Region: PRK09302 74546003902 KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124 74546003903 Walker A motif; other site 74546003904 ATP binding site [chemical binding]; other site 74546003905 Walker B motif; other site 74546003906 recA bacterial DNA recombination protein; Region: RecA; cl17211 74546003907 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 74546003908 Walker A motif; other site 74546003909 ATP binding site [chemical binding]; other site 74546003910 Walker B motif; other site 74546003911 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 74546003912 tetramer interface [polypeptide binding]; other site 74546003913 dimer interface [polypeptide binding]; other site 74546003914 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 74546003915 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 74546003916 Methyltransferase domain; Region: Methyltransf_12; pfam08242 74546003917 S-adenosylmethionine binding site [chemical binding]; other site 74546003918 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02755 74546003919 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 74546003920 RNA binding site [nucleotide binding]; other site 74546003921 active site 74546003922 Stage II sporulation protein; Region: SpoIID; pfam08486 74546003923 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 74546003924 ribonuclease Z; Region: RNase_Z; TIGR02651 74546003925 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 74546003926 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 74546003927 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 74546003928 catalytic loop [active] 74546003929 iron binding site [ion binding]; other site 74546003930 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 74546003931 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 74546003932 S-adenosylmethionine binding site [chemical binding]; other site 74546003933 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 74546003934 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 74546003935 ligand binding site [chemical binding]; other site 74546003936 NAD binding site [chemical binding]; other site 74546003937 dimerization interface [polypeptide binding]; other site 74546003938 catalytic site [active] 74546003939 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 74546003940 putative L-serine binding site [chemical binding]; other site 74546003941 photosystem II S4 domain protein; Region: PS_II_S4; TIGR03069 74546003942 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 74546003943 RNA binding surface [nucleotide binding]; other site 74546003944 PPOX class probable FMN-dependent enzyme, alr4036 family; Region: PPOX_FMN_cyano; TIGR04026 74546003945 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxase_2; pfam12766 74546003946 DoxX; Region: DoxX; pfam07681 74546003947 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 74546003948 short chain dehydrogenase; Provisional; Region: PRK06197 74546003949 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 74546003950 putative NAD(P) binding site [chemical binding]; other site 74546003951 active site 74546003952 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02705 74546003953 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 74546003954 Pirin-related protein [General function prediction only]; Region: COG1741 74546003955 Pirin; Region: Pirin; pfam02678 74546003956 Protein of unknown function (DUF1643); Region: DUF1643; pfam07799 74546003957 Predicted membrane protein (DUF2214); Region: DUF2214; pfam09980 74546003958 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 74546003959 GAF domain; Region: GAF; pfam01590 74546003960 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 74546003961 flavoprotein, HI0933 family; Region: TIGR00275 74546003962 Protein of unknown function (DUF861); Region: Cupin_3; pfam05899 74546003963 Protein of unknown function (DUF805); Region: DUF805; pfam05656 74546003964 Fatty acid desaturase; Region: FA_desaturase; pfam00487 74546003965 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 74546003966 putative di-iron ligands [ion binding]; other site 74546003967 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 74546003968 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 74546003969 Fatty acid desaturase; Region: FA_desaturase; pfam00487 74546003970 putative di-iron ligands [ion binding]; other site 74546003971 Protein of unknown function (DUF938); Region: DUF938; pfam06080 74546003972 putative high light inducible protein; Region: PHA02337 74546003973 putative high light inducible protein; Region: PHA02337 74546003974 putative high light inducible protein; Region: PHA02337 74546003975 Predicted permeases [General function prediction only]; Region: COG0795 74546003976 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 74546003977 Domain of Unknown Function (DUF1543); Region: DUF1543; pfam07566 74546003978 Domain of Unknown Function (DUF1543); Region: DUF1543; pfam07566 74546003979 DoxX; Region: DoxX; pfam07681 74546003980 Protein of unknown function (DUF3804); Region: DUF3804; pfam12707 74546003981 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 74546003982 putative high light inducible protein; Region: PHA02337 74546003983 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 74546003984 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 74546003985 putative active site [active] 74546003986 PhoH-like protein; Region: PhoH; pfam02562 74546003987 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 74546003988 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 74546003989 Protein of unknown function (DUF1330); Region: DUF1330; pfam07045 74546003990 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 74546003991 Protein of unknown function; Region: DUF3721; pfam12518 74546003992 Cupin domain; Region: Cupin_2; pfam07883 74546003993 putative high light inducible protein; Region: PHA02337 74546003994 putative high light inducible protein; Region: PHA02337 74546003995 putative high light inducible protein; Region: PHA02337 74546003996 putative high light inducible protein; Region: PHA02337 74546003997 Protein of unknown function; Region: DUF3721; pfam12518 74546003998 GLTT repeat (6 copies); Region: GLTT; pfam01744 74546003999 GLTT repeat (6 copies); Region: GLTT; pfam01744 74546004000 Protein of unknown function; Region: DUF3721; pfam12518 74546004001 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 74546004002 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 74546004003 Uncharacterized conserved protein [Function unknown]; Region: COG2947 74546004004 Protein of unknown function (DUF2811); Region: DUF2811; pfam10929 74546004005 Domain of unknown function (DUF1818); Region: DUF1818; pfam08848 74546004006 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 74546004007 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 74546004008 nucleotide binding site [chemical binding]; other site 74546004009 putative NEF/HSP70 interaction site [polypeptide binding]; other site 74546004010 SBD interface [polypeptide binding]; other site 74546004011 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 74546004012 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 74546004013 active site 74546004014 phosphoglyceromutase; Provisional; Region: PRK05434 74546004015 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307 74546004016 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 74546004017 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 74546004018 ring oligomerisation interface [polypeptide binding]; other site 74546004019 ATP/Mg binding site [chemical binding]; other site 74546004020 stacking interactions; other site 74546004021 hinge regions; other site 74546004022 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 74546004023 oligomerisation interface [polypeptide binding]; other site 74546004024 mobile loop; other site 74546004025 roof hairpin; other site 74546004026 ATP synthase CF1 beta subunit; Region: atpB; CHL00060 74546004027 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 74546004028 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 74546004029 alpha subunit interaction interface [polypeptide binding]; other site 74546004030 Walker A motif; other site 74546004031 ATP binding site [chemical binding]; other site 74546004032 Walker B motif; other site 74546004033 inhibitor binding site; inhibition site 74546004034 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 74546004035 ATP synthase CF1 epsilon subunit; Region: atpE; CHL00063 74546004036 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 74546004037 gamma subunit interface [polypeptide binding]; other site 74546004038 epsilon subunit interface [polypeptide binding]; other site 74546004039 LBP interface [polypeptide binding]; other site 74546004040 hypothetical protein; Provisional; Region: PRK02724 74546004041 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 74546004042 proline aminopeptidase P II; Provisional; Region: PRK10879 74546004043 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 74546004044 active site 74546004045 Domain of unknown function DUF21; Region: DUF21; pfam01595 74546004046 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 74546004047 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 74546004048 G1 box; other site 74546004049 GTP/Mg2+ binding site [chemical binding]; other site 74546004050 G2 box; other site 74546004051 Switch I region; other site 74546004052 G3 box; other site 74546004053 Switch II region; other site 74546004054 Domain of unknown function (DUF697); Region: DUF697; pfam05128 74546004055 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 74546004056 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 74546004057 active site 74546004058 (T/H)XGH motif; other site 74546004059 NAD synthetase; Provisional; Region: PRK13981 74546004060 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 74546004061 multimer interface [polypeptide binding]; other site 74546004062 active site 74546004063 catalytic triad [active] 74546004064 protein interface 1 [polypeptide binding]; other site 74546004065 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 74546004066 homodimer interface [polypeptide binding]; other site 74546004067 NAD binding pocket [chemical binding]; other site 74546004068 ATP binding pocket [chemical binding]; other site 74546004069 Mg binding site [ion binding]; other site 74546004070 active-site loop [active] 74546004071 Protein of unknown function (DUF3326); Region: DUF3326; pfam11805 74546004072 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 74546004073 catalytic loop [active] 74546004074 iron binding site [ion binding]; other site 74546004075 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 74546004076 core domain interface [polypeptide binding]; other site 74546004077 delta subunit interface [polypeptide binding]; other site 74546004078 epsilon subunit interface [polypeptide binding]; other site 74546004079 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 74546004080 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 74546004081 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 74546004082 beta subunit interaction interface [polypeptide binding]; other site 74546004083 Walker A motif; other site 74546004084 ATP binding site [chemical binding]; other site 74546004085 Walker B motif; other site 74546004086 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 74546004087 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13429 74546004088 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 74546004089 F0F1 ATP synthase subunit B; Validated; Region: PRK07352 74546004090 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 74546004091 F0F1 ATP synthase subunit B'; Validated; Region: PRK07353 74546004092 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 74546004093 ATP synthase CF0 C subunit; Region: atpH; CHL00061 74546004094 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 74546004095 ATP synthase CF0 A subunit; Region: atpI; CHL00046 74546004096 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 74546004097 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 74546004098 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 74546004099 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 74546004100 ResB-like family; Region: ResB; pfam05140 74546004101 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 74546004102 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 74546004103 Nitrogen regulatory protein P-II; Region: P-II; smart00938 74546004104 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 74546004105 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 74546004106 RNA binding surface [nucleotide binding]; other site 74546004107 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 74546004108 adenylosuccinate lyase; Provisional; Region: PRK07380 74546004109 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 74546004110 tetramer interface [polypeptide binding]; other site 74546004111 active site 74546004112 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 74546004113 fumarate hydratase; Reviewed; Region: fumC; PRK00485 74546004114 Class II fumarases; Region: Fumarase_classII; cd01362 74546004115 active site 74546004116 tetramer interface [polypeptide binding]; other site 74546004117 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 74546004118 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 74546004119 ATP binding site [chemical binding]; other site 74546004120 putative Mg++ binding site [ion binding]; other site 74546004121 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 74546004122 nucleotide binding region [chemical binding]; other site 74546004123 ATP-binding site [chemical binding]; other site 74546004124 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 74546004125 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 74546004126 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 74546004127 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 74546004128 catalytic residue [active] 74546004129 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 74546004130 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 74546004131 S-adenosylmethionine binding site [chemical binding]; other site 74546004132 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 74546004133 AAA domain; Region: AAA_26; pfam13500 74546004134 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 74546004135 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 74546004136 inhibitor-cofactor binding pocket; inhibition site 74546004137 pyridoxal 5'-phosphate binding site [chemical binding]; other site 74546004138 catalytic residue [active] 74546004139 Protein of unknown function (DUF3143); Region: DUF3143; pfam11341 74546004140 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 74546004141 HSP70 interaction site [polypeptide binding]; other site 74546004142 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 74546004143 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 74546004144 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 74546004145 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 74546004146 active site 74546004147 catalytic tetrad [active] 74546004148 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 74546004149 Protein of unknown function (DUF1257); Region: DUF1257; pfam06868 74546004150 Protein of unknown function (DUF2997); Region: DUF2997; pfam11211 74546004151 HEAT repeats; Region: HEAT_2; pfam13646 74546004152 HEAT repeats; Region: HEAT_2; pfam13646 74546004153 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14457 74546004154 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 74546004155 FeS/SAM binding site; other site 74546004156 light-harvesting-like protein 3; Provisional; Region: PLN00014 74546004157 DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597 74546004158 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 74546004159 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 74546004160 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 74546004161 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 74546004162 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 74546004163 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 74546004164 DNA binding site [nucleotide binding] 74546004165 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 74546004166 DNA-directed RNA polymerase subunit gamma; Provisional; Region: rpoC1; PRK02625 74546004167 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 74546004168 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 74546004169 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 74546004170 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 74546004171 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 74546004172 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 74546004173 RPB1 interaction site [polypeptide binding]; other site 74546004174 RPB10 interaction site [polypeptide binding]; other site 74546004175 RPB11 interaction site [polypeptide binding]; other site 74546004176 RPB3 interaction site [polypeptide binding]; other site 74546004177 RPB12 interaction site [polypeptide binding]; other site 74546004178 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 74546004179 active site 74546004180 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 74546004181 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 74546004182 histidinol dehydrogenase; Region: hisD; TIGR00069 74546004183 NAD binding site [chemical binding]; other site 74546004184 dimerization interface [polypeptide binding]; other site 74546004185 product binding site; other site 74546004186 substrate binding site [chemical binding]; other site 74546004187 zinc binding site [ion binding]; other site 74546004188 catalytic residues [active] 74546004189 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 74546004190 tetramer (dimer of dimers) interface [polypeptide binding]; other site 74546004191 active site 74546004192 dimer interface [polypeptide binding]; other site 74546004193 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 74546004194 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 74546004195 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 74546004196 protein binding site [polypeptide binding]; other site 74546004197 hypothetical protein; Provisional; Region: PRK14646 74546004198 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG0779 74546004199 heptamer interface [polypeptide binding]; other site 74546004200 Sm1 motif; other site 74546004201 hexamer interface [polypeptide binding]; other site 74546004202 RNA binding site [nucleotide binding]; other site 74546004203 Sm2 motif; other site 74546004204 NusA N-terminal domain; Region: NusA_N; pfam08529 74546004205 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 74546004206 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 74546004207 RNA binding site [nucleotide binding]; other site 74546004208 homodimer interface [polypeptide binding]; other site 74546004209 NusA-like KH domain; Region: KH_5; pfam13184 74546004210 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 74546004211 G-X-X-G motif; other site 74546004212 Protein of unknown function (DUF448); Region: DUF448; pfam04296 74546004213 putative RNA binding cleft [nucleotide binding]; other site 74546004214 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 74546004215 translation initiation factor IF-2; Region: IF-2; TIGR00487 74546004216 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 74546004217 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 74546004218 G1 box; other site 74546004219 putative GEF interaction site [polypeptide binding]; other site 74546004220 GTP/Mg2+ binding site [chemical binding]; other site 74546004221 Switch I region; other site 74546004222 G2 box; other site 74546004223 G3 box; other site 74546004224 Switch II region; other site 74546004225 G4 box; other site 74546004226 G5 box; other site 74546004227 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 74546004228 Translation-initiation factor 2; Region: IF-2; pfam11987 74546004229 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 74546004230 Protein of unknown function (DUF3493); Region: DUF3493; pfam11998 74546004231 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 74546004232 Ligand binding site; other site 74546004233 Putative Catalytic site; other site 74546004234 DXD motif; other site 74546004235 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 74546004236 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 74546004237 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 74546004238 FeS/SAM binding site; other site 74546004239 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 74546004240 L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590 74546004241 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 74546004242 pyridoxal 5'-phosphate binding site [chemical binding]; other site 74546004243 homodimer interface [polypeptide binding]; other site 74546004244 catalytic residue [active] 74546004245 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 74546004246 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 74546004247 homodimer interface [polypeptide binding]; other site 74546004248 oligonucleotide binding site [chemical binding]; other site 74546004249 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 74546004250 RNA/DNA hybrid binding site [nucleotide binding]; other site 74546004251 active site 74546004252 Protein of unknown function (DUF1997); Region: DUF1997; pfam09366 74546004253 prephenate dehydratase; Provisional; Region: PRK11898 74546004254 Prephenate dehydratase; Region: PDT; pfam00800 74546004255 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 74546004256 putative L-Phe binding site [chemical binding]; other site 74546004257 tocopherol O-methyltransferase; Region: PLN02244 74546004258 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 74546004259 S-adenosylmethionine binding site [chemical binding]; other site 74546004260 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 74546004261 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 74546004262 elongation factor Tu; Reviewed; Region: PRK00049 74546004263 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 74546004264 G1 box; other site 74546004265 GEF interaction site [polypeptide binding]; other site 74546004266 GTP/Mg2+ binding site [chemical binding]; other site 74546004267 Switch I region; other site 74546004268 G2 box; other site 74546004269 G3 box; other site 74546004270 Switch II region; other site 74546004271 G4 box; other site 74546004272 G5 box; other site 74546004273 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 74546004274 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 74546004275 Antibiotic Binding Site [chemical binding]; other site 74546004276 elongation factor G; Reviewed; Region: PRK00007 74546004277 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 74546004278 G1 box; other site 74546004279 putative GEF interaction site [polypeptide binding]; other site 74546004280 GTP/Mg2+ binding site [chemical binding]; other site 74546004281 Switch I region; other site 74546004282 G2 box; other site 74546004283 G3 box; other site 74546004284 Switch II region; other site 74546004285 G4 box; other site 74546004286 G5 box; other site 74546004287 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 74546004288 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 74546004289 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 74546004290 30S ribosomal protein S7; Validated; Region: PRK05302 74546004291 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 74546004292 S17 interaction site [polypeptide binding]; other site 74546004293 S8 interaction site; other site 74546004294 16S rRNA interaction site [nucleotide binding]; other site 74546004295 streptomycin interaction site [chemical binding]; other site 74546004296 23S rRNA interaction site [nucleotide binding]; other site 74546004297 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 74546004298 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 74546004299 active site 74546004300 dimer interface [polypeptide binding]; other site 74546004301 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 74546004302 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 74546004303 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 74546004304 active site 74546004305 FMN binding site [chemical binding]; other site 74546004306 substrate binding site [chemical binding]; other site 74546004307 3Fe-4S cluster binding site [ion binding]; other site 74546004308 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 74546004309 domain interface; other site 74546004310 YCII-related domain; Region: YCII; cl00999 74546004311 lipoyl synthase; Provisional; Region: PRK05481 74546004312 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 74546004313 FeS/SAM binding site; other site 74546004314 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 74546004315 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 74546004316 catalytic residues [active] 74546004317 catalytic nucleophile [active] 74546004318 Presynaptic Site I dimer interface [polypeptide binding]; other site 74546004319 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 74546004320 Synaptic Flat tetramer interface [polypeptide binding]; other site 74546004321 Synaptic Site I dimer interface [polypeptide binding]; other site 74546004322 DNA binding site [nucleotide binding] 74546004323 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 74546004324 NlpC/P60 family; Region: NLPC_P60; pfam00877 74546004325 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 74546004326 photosystem I reaction center protein subunit XI; Provisional; Region: PRK00704 74546004327 photosystem I reaction center subunit VIII; Reviewed; Region: psaI; PRK11877 74546004328 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 74546004329 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 74546004330 Ligand binding site; other site 74546004331 Putative Catalytic site; other site 74546004332 DXD motif; other site 74546004333 photosystem I P700 chlorophyll a apoprotein A2; Provisional; Region: psaB; PRK13199 74546004334 photosystem I P700 chlorophyll a apoprotein A1; Provisional; Region: psaA; PRK13200 74546004335 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 74546004336 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 74546004337 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 74546004338 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 74546004339 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 74546004340 active site 74546004341 SAM binding site [chemical binding]; other site 74546004342 homodimer interface [polypeptide binding]; other site 74546004343 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 74546004344 haloacid dehalogenase superfamily, subfamily IA hydrolase, TIGR01548; Region: HAD-SF-IA-hyp1 74546004345 alanine racemase; Reviewed; Region: alr; PRK00053 74546004346 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 74546004347 active site 74546004348 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 74546004349 dimer interface [polypeptide binding]; other site 74546004350 substrate binding site [chemical binding]; other site 74546004351 catalytic residues [active] 74546004352 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 74546004353 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 74546004354 active site 74546004355 peptide chain release factor 1; Validated; Region: prfA; PRK00591 74546004356 This domain is found in peptide chain release factors; Region: PCRF; smart00937 74546004357 RF-1 domain; Region: RF-1; pfam00472 74546004358 ribosomal protein L31; Validated; Region: rpl31; CHL00136 74546004359 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 74546004360 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 74546004361 23S rRNA interface [nucleotide binding]; other site 74546004362 L3 interface [polypeptide binding]; other site 74546004363 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 74546004364 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 74546004365 dimerization interface 3.5A [polypeptide binding]; other site 74546004366 active site 74546004367 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 74546004368 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 74546004369 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 74546004370 alphaNTD homodimer interface [polypeptide binding]; other site 74546004371 alphaNTD - beta interaction site [polypeptide binding]; other site 74546004372 alphaNTD - beta' interaction site [polypeptide binding]; other site 74546004373 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 74546004374 30S ribosomal protein S11; Validated; Region: PRK05309 74546004375 ribosomal protein S13; Validated; Region: rps13; CHL00137 74546004376 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 74546004377 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 74546004378 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 74546004379 adenylate kinase; Reviewed; Region: adk; PRK00279 74546004380 AMP-binding site [chemical binding]; other site 74546004381 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 74546004382 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 74546004383 SecY translocase; Region: SecY; pfam00344 74546004384 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 74546004385 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 74546004386 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 74546004387 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 74546004388 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 74546004389 5S rRNA interface [nucleotide binding]; other site 74546004390 L27 interface [polypeptide binding]; other site 74546004391 23S rRNA interface [nucleotide binding]; other site 74546004392 L5 interface [polypeptide binding]; other site 74546004393 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 74546004394 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 74546004395 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 74546004396 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 74546004397 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 74546004398 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 74546004399 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 74546004400 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 74546004401 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 74546004402 RNA binding site [nucleotide binding]; other site 74546004403 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 74546004404 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 74546004405 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 74546004406 23S rRNA interface [nucleotide binding]; other site 74546004407 putative translocon interaction site; other site 74546004408 signal recognition particle (SRP54) interaction site; other site 74546004409 L23 interface [polypeptide binding]; other site 74546004410 trigger factor interaction site; other site 74546004411 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 74546004412 23S rRNA interface [nucleotide binding]; other site 74546004413 5S rRNA interface [nucleotide binding]; other site 74546004414 putative antibiotic binding site [chemical binding]; other site 74546004415 L25 interface [polypeptide binding]; other site 74546004416 L27 interface [polypeptide binding]; other site 74546004417 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 74546004418 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 74546004419 G-X-X-G motif; other site 74546004420 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 74546004421 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 74546004422 putative translocon binding site; other site 74546004423 protein-rRNA interface [nucleotide binding]; other site 74546004424 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 74546004425 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 74546004426 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 74546004427 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 74546004428 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 74546004429 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 74546004430 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 74546004431 NADH-quinone oxidoreductase cyanobacterial subunit N; Region: NdhN; pfam11909 74546004432 Iron-Sulfur binding protein C terminal; Region: LdpA_C; pfam12617 74546004433 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 74546004434 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 74546004435 motif II; other site 74546004436 recombinase A; Provisional; Region: recA; PRK09354 74546004437 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 74546004438 hexamer interface [polypeptide binding]; other site 74546004439 Walker A motif; other site 74546004440 ATP binding site [chemical binding]; other site 74546004441 Walker B motif; other site 74546004442 Protein of unknown function (DUF2839); Region: DUF2839; pfam10999 74546004443 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 74546004444 arogenate dehydrogenase; Reviewed; Region: PRK07417 74546004445 prephenate dehydrogenase; Validated; Region: PRK08507 74546004446 C-3',4' desaturase CrtD; Region: desat_CrtD; TIGR02733 74546004447 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 74546004448 Fructosamine kinase; Region: Fructosamin_kin; cl17579 74546004449 Phosphotransferase enzyme family; Region: APH; pfam01636 74546004450 Domain of unknown function (DUF4308); Region: DUF4308; pfam14159 74546004451 hypothetical protein; Validated; Region: PRK07411 74546004452 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 74546004453 ATP binding site [chemical binding]; other site 74546004454 substrate interface [chemical binding]; other site 74546004455 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 74546004456 active site residue [active] 74546004457 hypothetical protein; Validated; Region: PRK07413 74546004458 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; pfam02572 74546004459 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 74546004460 Walker A motif; other site 74546004461 homodimer interface [polypeptide binding]; other site 74546004462 ATP binding site [chemical binding]; other site 74546004463 hydroxycobalamin binding site [chemical binding]; other site 74546004464 Walker B motif; other site 74546004465 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 74546004466 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 74546004467 Ligand Binding Site [chemical binding]; other site 74546004468 S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK02770 74546004469 recombination protein F; Reviewed; Region: recF; PRK00064 74546004470 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 74546004471 Q-loop/lid; other site 74546004472 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 74546004473 ABC transporter signature motif; other site 74546004474 Walker B; other site 74546004475 D-loop; other site 74546004476 H-loop/switch region; other site 74546004477 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 74546004478 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 74546004479 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 74546004480 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 74546004481 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 74546004482 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 74546004483 PsaD; Region: PsaD; pfam02531 74546004484 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 74546004485 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 74546004486 dimer interface [polypeptide binding]; other site 74546004487 phosphorylation site [posttranslational modification] 74546004488 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 74546004489 Domain of unknown function DUF59; Region: DUF59; pfam01883 74546004490 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 74546004491 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 74546004492 Walker A motif; other site 74546004493 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 74546004494 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 74546004495 Protein of unknown function (DUF3529); Region: DUF3529; pfam12046 74546004496 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 74546004497 catalytic site [active] 74546004498 putative active site [active] 74546004499 putative substrate binding site [chemical binding]; other site 74546004500 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370 74546004501 conserved hypothetical protein; Region: TIGR03492 74546004502 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 74546004503 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 74546004504 dimerization interface [polypeptide binding]; other site 74546004505 putative ATP binding site [chemical binding]; other site 74546004506 bifunctional pantoate ligase/cytidylate kinase; Provisional; Region: PRK13477 74546004507 Pantoate-beta-alanine ligase; Region: PanC; cd00560 74546004508 active site 74546004509 ATP-binding site [chemical binding]; other site 74546004510 pantoate-binding site; other site 74546004511 HXXH motif; other site 74546004512 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 74546004513 CMP-binding site; other site 74546004514 The sites determining sugar specificity; other site 74546004515 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 74546004516 Low molecular weight phosphatase family; Region: LMWPc; cd00115 74546004517 active site 74546004518 phycoerythrobilin:ferredoxin oxidoreductase; Provisional; Region: PRK13248 74546004519 dihydrobiliverdin:ferredoxin oxidoreductase; Provisional; Region: PRK13246 74546004520 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 74546004521 heme binding pocket [chemical binding]; other site 74546004522 heme ligand [chemical binding]; other site 74546004523 isocitrate dehydrogenase; Validated; Region: PRK07362 74546004524 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 74546004525 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 74546004526 Aldose 1-epimerase, similar to Synechocystis Slr1438; Region: Aldose_epim_Slr1438; cd09025 74546004527 active site 74546004528 catalytic residues [active] 74546004529 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 74546004530 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 74546004531 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 74546004532 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 74546004533 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 74546004534 homodimer interface [polypeptide binding]; other site 74546004535 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 74546004536 active site pocket [active] 74546004537 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 74546004538 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 74546004539 dimerization interface [polypeptide binding]; other site 74546004540 active site 74546004541 metal binding site [ion binding]; metal-binding site 74546004542 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 74546004543 dsRNA binding site [nucleotide binding]; other site 74546004544 Protein of unknown function (DUF3252); Region: DUF3252; pfam11623 74546004545 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 74546004546 RimM N-terminal domain; Region: RimM; pfam01782 74546004547 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 74546004548 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 74546004549 glutaminase active site [active] 74546004550 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 74546004551 dimer interface [polypeptide binding]; other site 74546004552 active site 74546004553 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 74546004554 dimer interface [polypeptide binding]; other site 74546004555 active site 74546004556 photosystem I subunit VII; Region: psaC; CHL00065 74546004557 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 74546004558 acyl carrier protein; Provisional; Region: acpP; PRK00982 74546004559 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 74546004560 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 74546004561 dimer interface [polypeptide binding]; other site 74546004562 active site 74546004563 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 74546004564 transketolase; Region: PLN02790 74546004565 TPP-binding site [chemical binding]; other site 74546004566 dimer interface [polypeptide binding]; other site 74546004567 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 74546004568 PYR/PP interface [polypeptide binding]; other site 74546004569 dimer interface [polypeptide binding]; other site 74546004570 TPP binding site [chemical binding]; other site 74546004571 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 74546004572 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 74546004573 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 74546004574 Protein of unknown function (DUF3188); Region: DUF3188; pfam11384 74546004575 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 74546004576 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 74546004577 metal binding site [ion binding]; metal-binding site 74546004578 dimer interface [polypeptide binding]; other site 74546004579 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 74546004580 binding surface 74546004581 TPR motif; other site 74546004582 TPR repeat; Region: TPR_11; pfam13414 74546004583 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 74546004584 binding surface 74546004585 TPR motif; other site 74546004586 TPR repeat; Region: TPR_11; pfam13414 74546004587 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 74546004588 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 74546004589 Walker A motif; other site 74546004590 ATP binding site [chemical binding]; other site 74546004591 Walker B motif; other site 74546004592 arginine finger; other site 74546004593 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 74546004594 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 74546004595 SmpB-tmRNA interface; other site 74546004596 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 74546004597 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 74546004598 dimer interface [polypeptide binding]; other site 74546004599 putative anticodon binding site; other site 74546004600 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 74546004601 motif 1; other site 74546004602 active site 74546004603 motif 2; other site 74546004604 motif 3; other site 74546004605 Ycf27; Reviewed; Region: orf27; CHL00148 74546004606 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 74546004607 active site 74546004608 phosphorylation site [posttranslational modification] 74546004609 intermolecular recognition site; other site 74546004610 dimerization interface [polypeptide binding]; other site 74546004611 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 74546004612 DNA binding site [nucleotide binding] 74546004613 Protein-interacting V-domain of mammalian Alix and related domains; Region: V_Alix_like; cl14654 74546004614 rod shape-determining protein MreC; Provisional; Region: PRK13922 74546004615 rod shape-determining protein MreC; Region: MreC; pfam04085 74546004616 rod shape-determining protein MreB; Provisional; Region: PRK13927 74546004617 MreB and similar proteins; Region: MreB_like; cd10225 74546004618 nucleotide binding site [chemical binding]; other site 74546004619 Mg binding site [ion binding]; other site 74546004620 putative protofilament interaction site [polypeptide binding]; other site 74546004621 RodZ interaction site [polypeptide binding]; other site 74546004622 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 74546004623 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 74546004624 dimer interface [polypeptide binding]; other site 74546004625 ssDNA binding site [nucleotide binding]; other site 74546004626 tetramer (dimer of dimers) interface [polypeptide binding]; other site 74546004627 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 74546004628 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 74546004629 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 74546004630 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 74546004631 homotetramer interface [polypeptide binding]; other site 74546004632 ligand binding site [chemical binding]; other site 74546004633 catalytic site [active] 74546004634 NAD binding site [chemical binding]; other site 74546004635 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 74546004636 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 74546004637 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 74546004638 putative substrate binding site [chemical binding]; other site 74546004639 putative ATP binding site [chemical binding]; other site 74546004640 hydrolase, alpha/beta fold family protein; Region: PLN02824 74546004641 Serine hydrolase; Region: Ser_hydrolase; cl17834 74546004642 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 74546004643 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 74546004644 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 74546004645 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 74546004646 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 74546004647 Mg2+ transporter (mgtE); Region: mgtE; TIGR00400 74546004648 MgtE intracellular N domain; Region: MgtE_N; smart00924 74546004649 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 74546004650 Divalent cation transporter; Region: MgtE; pfam01769 74546004651 CrcB-like protein; Region: CRCB; pfam02537 74546004652 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 74546004653 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 74546004654 ATP binding site [chemical binding]; other site 74546004655 Mg2+ binding site [ion binding]; other site 74546004656 G-X-G motif; other site 74546004657 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 74546004658 anchoring element; other site 74546004659 dimer interface [polypeptide binding]; other site 74546004660 ATP binding site [chemical binding]; other site 74546004661 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 74546004662 active site 74546004663 putative metal-binding site [ion binding]; other site 74546004664 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 74546004665 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 74546004666 tRNA dimethylallyltransferase; Region: miaA; TIGR00174 74546004667 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 74546004668 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 74546004669 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 74546004670 Predicted transcriptional regulators [Transcription]; Region: COG1725 74546004671 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 74546004672 DNA-binding site [nucleotide binding]; DNA binding site 74546004673 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 74546004674 serine O-acetyltransferase; Region: cysE; TIGR01172 74546004675 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 74546004676 trimer interface [polypeptide binding]; other site 74546004677 active site 74546004678 substrate binding site [chemical binding]; other site 74546004679 CoA binding site [chemical binding]; other site 74546004680 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12902 74546004681 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 74546004682 ATP binding site [chemical binding]; other site 74546004683 putative Mg++ binding site [ion binding]; other site 74546004684 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 74546004685 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 74546004686 Coenzyme A binding pocket [chemical binding]; other site 74546004687 SnoaL-like domain; Region: SnoaL_2; pfam12680 74546004688 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 74546004689 homopentamer interface [polypeptide binding]; other site 74546004690 active site 74546004691 photosystem II core protein PsbZ; Region: PS_II_psbZ; TIGR03043 74546004692 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 74546004693 MutS domain I; Region: MutS_I; pfam01624 74546004694 MutS domain II; Region: MutS_II; pfam05188 74546004695 MutS domain III; Region: MutS_III; pfam05192 74546004696 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 74546004697 Walker A/P-loop; other site 74546004698 ATP binding site [chemical binding]; other site 74546004699 Q-loop/lid; other site 74546004700 ABC transporter signature motif; other site 74546004701 Walker B; other site 74546004702 D-loop; other site 74546004703 H-loop/switch region; other site 74546004704 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 74546004705 Precorrin-8X methylmutase; Region: CbiC; pfam02570 74546004706 DNA polymerase III subunit delta; Validated; Region: PRK07452 74546004707 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 74546004708 aspartate kinase; Provisional; Region: PRK07431 74546004709 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 74546004710 putative nucleotide binding site [chemical binding]; other site 74546004711 putative catalytic residues [active] 74546004712 putative Mg ion binding site [ion binding]; other site 74546004713 putative aspartate binding site [chemical binding]; other site 74546004714 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 74546004715 putative allosteric regulatory site; other site 74546004716 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 74546004717 putative allosteric regulatory residue; other site 74546004718 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 74546004719 putative allosteric regulatory site; other site 74546004720 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 74546004721 excinuclease ABC subunit B; Provisional; Region: PRK05298 74546004722 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 74546004723 ATP binding site [chemical binding]; other site 74546004724 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 74546004725 nucleotide binding region [chemical binding]; other site 74546004726 ATP-binding site [chemical binding]; other site 74546004727 Ultra-violet resistance protein B; Region: UvrB; pfam12344 74546004728 UvrB/uvrC motif; Region: UVR; pfam02151 74546004729 Protein of unknown function (DUF561); Region: DUF561; pfam04481 74546004730 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 74546004731 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 74546004732 Ligand Binding Site [chemical binding]; other site 74546004733 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 74546004734 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 74546004735 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 74546004736 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 74546004737 dihydrodipicolinate synthase; Region: dapA; TIGR00674 74546004738 dimer interface [polypeptide binding]; other site 74546004739 active site 74546004740 catalytic residue [active] 74546004741 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 74546004742 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 74546004743 trigger factor; Region: tig; TIGR00115 74546004744 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 74546004745 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 74546004746 Clp protease; Region: CLP_protease; pfam00574 74546004747 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 74546004748 oligomer interface [polypeptide binding]; other site 74546004749 active site residues [active] 74546004750 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 74546004751 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 74546004752 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 74546004753 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 74546004754 Walker A motif; other site 74546004755 ATP binding site [chemical binding]; other site 74546004756 Walker B motif; other site 74546004757 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 74546004758 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14948 74546004759 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 74546004760 Walker A motif; other site 74546004761 ATP binding site [chemical binding]; other site 74546004762 Walker B motif; other site 74546004763 arginine finger; other site 74546004764 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 74546004765 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 74546004766 DXD motif; other site 74546004767 Stage II sporulation protein; Region: SpoIID; pfam08486 74546004768 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 74546004769 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 74546004770 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 74546004771 23S rRNA binding site [nucleotide binding]; other site 74546004772 L21 binding site [polypeptide binding]; other site 74546004773 L13 binding site [polypeptide binding]; other site 74546004774 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 74546004775 binding surface 74546004776 TPR motif; other site 74546004777 TPR repeat; Region: TPR_11; pfam13414 74546004778 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 74546004779 ThiS interaction site; other site 74546004780 putative active site [active] 74546004781 tetramer interface [polypeptide binding]; other site 74546004782 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 74546004783 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 74546004784 NAD(P) binding site [chemical binding]; other site 74546004785 active site 74546004786 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 74546004787 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 74546004788 glycine dehydrogenase; Provisional; Region: PRK05367 74546004789 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 74546004790 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 74546004791 catalytic residue [active] 74546004792 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 74546004793 tetramer interface [polypeptide binding]; other site 74546004794 pyridoxal 5'-phosphate binding site [chemical binding]; other site 74546004795 catalytic residue [active] 74546004796 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 74546004797 lipoyl attachment site [posttranslational modification]; other site 74546004798 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 74546004799 Aluminium resistance protein; Region: Alum_res; pfam06838 74546004800 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 74546004801 Fatty acid desaturase; Region: FA_desaturase; pfam00487 74546004802 Di-iron ligands [ion binding]; other site 74546004803 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 74546004804 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 74546004805 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 74546004806 replicative DNA helicase; Region: DnaB; TIGR00665 74546004807 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 74546004808 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 74546004809 Walker A motif; other site 74546004810 ATP binding site [chemical binding]; other site 74546004811 Walker B motif; other site 74546004812 DNA binding loops [nucleotide binding] 74546004813 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 74546004814 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 74546004815 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 74546004816 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 74546004817 Protein of unknown function (DUF98); Region: DUF98; pfam01947 74546004818 SprT-like family; Region: SprT-like; pfam10263 74546004819 SprT homologues; Region: SprT; cl01182 74546004820 DNA ligase; Provisional; Region: 30; PHA02587 74546004821 Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015 74546004822 active site 74546004823 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of kDNA ligase-like ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_kDNA_ligase_like; cd08041 74546004824 DNA binding site [nucleotide binding] 74546004825 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 74546004826 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 74546004827 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 74546004828 active site 74546004829 HIGH motif; other site 74546004830 nucleotide binding site [chemical binding]; other site 74546004831 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 74546004832 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 74546004833 active site 74546004834 KMSKS motif; other site 74546004835 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 74546004836 tRNA binding surface [nucleotide binding]; other site 74546004837 anticodon binding site; other site 74546004838 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 74546004839 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 74546004840 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 74546004841 homodimer interface [polypeptide binding]; other site 74546004842 metal binding site [ion binding]; metal-binding site 74546004843 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 74546004844 homodimer interface [polypeptide binding]; other site 74546004845 active site 74546004846 putative chemical substrate binding site [chemical binding]; other site 74546004847 metal binding site [ion binding]; metal-binding site 74546004848 spermidine synthase; Provisional; Region: PRK00811 74546004849 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 74546004850 S-adenosylmethionine binding site [chemical binding]; other site 74546004851 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 74546004852 agmatinase; Region: agmatinase; TIGR01230 74546004853 putative active site [active] 74546004854 Mn binding site [ion binding]; other site 74546004855 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 74546004856 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 74546004857 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 74546004858 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 74546004859 dimer interface [polypeptide binding]; other site 74546004860 anticodon binding site; other site 74546004861 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 74546004862 motif 1; other site 74546004863 dimer interface [polypeptide binding]; other site 74546004864 active site 74546004865 motif 2; other site 74546004866 GAD domain; Region: GAD; pfam02938 74546004867 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 74546004868 active site 74546004869 motif 3; other site 74546004870 CTP synthetase; Validated; Region: pyrG; PRK05380 74546004871 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 74546004872 Catalytic site [active] 74546004873 active site 74546004874 UTP binding site [chemical binding]; other site 74546004875 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 74546004876 active site 74546004877 putative oxyanion hole; other site 74546004878 catalytic triad [active] 74546004879 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 74546004880 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 74546004881 FeS/SAM binding site; other site 74546004882 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 74546004883 Ligand Binding Site [chemical binding]; other site 74546004884 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 74546004885 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 74546004886 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 74546004887 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 74546004888 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 74546004889 homodimer interface [polypeptide binding]; other site 74546004890 substrate-cofactor binding pocket; other site 74546004891 Aminotransferase class IV; Region: Aminotran_4; pfam01063 74546004892 pyridoxal 5'-phosphate binding site [chemical binding]; other site 74546004893 catalytic residue [active] 74546004894 diphthine synthase; Region: dph5; TIGR00522 74546004895 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 74546004896 active site 74546004897 SAM binding site [chemical binding]; other site 74546004898 homodimer interface [polypeptide binding]; other site 74546004899 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 74546004900 Major Facilitator Superfamily; Region: MFS_1; pfam07690 74546004901 putative substrate translocation pore; other site 74546004902 polyphosphate kinase; Provisional; Region: PRK05443 74546004903 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 74546004904 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 74546004905 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 74546004906 putative domain interface [polypeptide binding]; other site 74546004907 putative active site [active] 74546004908 catalytic site [active] 74546004909 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 74546004910 putative domain interface [polypeptide binding]; other site 74546004911 putative active site [active] 74546004912 catalytic site [active] 74546004913 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 74546004914 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 74546004915 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 74546004916 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 74546004917 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 74546004918 DNA binding residues [nucleotide binding] 74546004919 Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170 74546004920 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 74546004921 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 74546004922 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 74546004923 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 74546004924 substrate binding site [chemical binding]; other site 74546004925 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 74546004926 substrate binding site [chemical binding]; other site 74546004927 ligand binding site [chemical binding]; other site 74546004928 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 74546004929 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 74546004930 Cl- selectivity filter; other site 74546004931 Cl- binding residues [ion binding]; other site 74546004932 pore gating glutamate residue; other site 74546004933 dimer interface [polypeptide binding]; other site 74546004934 H+/Cl- coupling transport residue; other site 74546004935 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 74546004936 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 74546004937 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 74546004938 putative active site [active] 74546004939 putative substrate binding site [chemical binding]; other site 74546004940 putative cosubstrate binding site; other site 74546004941 catalytic site [active] 74546004942 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 74546004943 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 74546004944 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 74546004945 nucleotide binding site [chemical binding]; other site 74546004946 NEF interaction site [polypeptide binding]; other site 74546004947 SBD interface [polypeptide binding]; other site 74546004948 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 74546004949 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 74546004950 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 74546004951 shikimate binding site; other site 74546004952 NAD(P) binding site [chemical binding]; other site 74546004953 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 74546004954 argininosuccinate synthase; Provisional; Region: PRK13820 74546004955 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 74546004956 ANP binding site [chemical binding]; other site 74546004957 Substrate Binding Site II [chemical binding]; other site 74546004958 Substrate Binding Site I [chemical binding]; other site 74546004959 Protein of unknown function (DUF3134); Region: DUF3134; pfam11332 74546004960 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 74546004961 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 74546004962 Mg++ binding site [ion binding]; other site 74546004963 putative catalytic motif [active] 74546004964 putative substrate binding site [chemical binding]; other site 74546004965 sucrose-phosphate synthase, putative, glycosyltransferase domain; Region: sucr_P_syn_N; TIGR02472 74546004966 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 74546004967 putative ADP-binding pocket [chemical binding]; other site 74546004968 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 74546004969 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 74546004970 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 74546004971 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 74546004972 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 74546004973 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 74546004974 Walker A/P-loop; other site 74546004975 ATP binding site [chemical binding]; other site 74546004976 Q-loop/lid; other site 74546004977 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 74546004978 ABC transporter signature motif; other site 74546004979 Walker B; other site 74546004980 D-loop; other site 74546004981 H-loop/switch region; other site 74546004982 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 74546004983 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 74546004984 active site 74546004985 substrate binding site [chemical binding]; other site 74546004986 ATP binding site [chemical binding]; other site 74546004987 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 74546004988 threonine synthase; Reviewed; Region: PRK06721 74546004989 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 74546004990 homodimer interface [polypeptide binding]; other site 74546004991 pyridoxal 5'-phosphate binding site [chemical binding]; other site 74546004992 catalytic residue [active]