-- dump date 20140620_000311 -- class Genbank::misc_feature -- table misc_feature_note -- id note 74547000001 DNA polymerase III subunit beta; Validated; Region: PRK05643 74547000002 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 74547000003 putative DNA binding surface [nucleotide binding]; other site 74547000004 dimer interface [polypeptide binding]; other site 74547000005 beta-clamp/clamp loader binding surface; other site 74547000006 beta-clamp/translesion DNA polymerase binding surface; other site 74547000007 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 74547000008 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 74547000009 dimerization interface [polypeptide binding]; other site 74547000010 ATP binding site [chemical binding]; other site 74547000011 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 74547000012 dimerization interface [polypeptide binding]; other site 74547000013 ATP binding site [chemical binding]; other site 74547000014 amidophosphoribosyltransferase; Provisional; Region: PRK09246 74547000015 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 74547000016 active site 74547000017 tetramer interface [polypeptide binding]; other site 74547000018 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 74547000019 active site 74547000020 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit [DNA replication, recombination, and repair]; Region: GyrA; COG0188 74547000021 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 74547000022 CAP-like domain; other site 74547000023 active site 74547000024 primary dimer interface [polypeptide binding]; other site 74547000025 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 74547000026 TPR motif; other site 74547000027 binding surface 74547000028 TPR repeat; Region: TPR_11; pfam13414 74547000029 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 74547000030 binding surface 74547000031 TPR motif; other site 74547000032 1 probable transmembrane helix predicted for by TMHMM2.0 74547000033 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 74547000034 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 74547000035 4 probable transmembrane helices predicted by TMHMM2.0 74547000036 Uncharacterized conserved protein [Function unknown]; Region: COG2928 74547000037 2 probable transmembrane helices predicted by TMHMM2.0 74547000038 transcription antitermination protein NusB; Provisional; Region: nusB; PRK09634 74547000039 putative RNA binding site [nucleotide binding]; other site 74547000040 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 74547000041 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 74547000042 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 74547000043 P loop; other site 74547000044 GTP binding site [chemical binding]; other site 74547000045 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 74547000046 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 74547000047 argininosuccinate lyase; Provisional; Region: PRK00855 74547000048 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 74547000049 active sites [active] 74547000050 tetramer interface [polypeptide binding]; other site 74547000051 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 74547000052 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 74547000053 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 74547000054 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 74547000055 FMN binding site [chemical binding]; other site 74547000056 active site 74547000057 catalytic residues [active] 74547000058 substrate binding site [chemical binding]; other site 74547000059 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 74547000060 SelR domain; Region: SelR; pfam01641 74547000061 flavoprotein, HI0933 family; Region: TIGR00275 74547000062 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 74547000063 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 74547000064 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 74547000065 3 probable transmembrane helices predicted by TMHMM2.0 74547000066 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 74547000067 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 74547000068 Walker A motif; other site 74547000069 ATP binding site [chemical binding]; other site 74547000070 Walker B motif; other site 74547000071 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 74547000072 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 74547000073 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 74547000074 Walker A motif; other site 74547000075 ATP binding site [chemical binding]; other site 74547000076 Walker B motif; other site 74547000077 GrpE; Region: GrpE; pfam01025 74547000078 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 74547000079 dimer interface [polypeptide binding]; other site 74547000080 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 74547000081 chaperone protein DnaJ; Provisional; Region: PRK14293 74547000082 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 74547000083 HSP70 interaction site [polypeptide binding]; other site 74547000084 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 74547000085 substrate binding site [polypeptide binding]; other site 74547000086 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 74547000087 Zn binding sites [ion binding]; other site 74547000088 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 74547000089 dimer interface [polypeptide binding]; other site 74547000090 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 74547000091 CPxP motif; other site 74547000092 Predicted GTPases [General function prediction only]; Region: COG1162 74547000093 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 74547000094 GTPase/Zn-binding domain interface [polypeptide binding]; other site 74547000095 GTP/Mg2+ binding site [chemical binding]; other site 74547000096 G4 box; other site 74547000097 G5 box; other site 74547000098 G1 box; other site 74547000099 Switch I region; other site 74547000100 G2 box; other site 74547000101 G3 box; other site 74547000102 Switch II region; other site 74547000103 hypothetical protein; Validated; Region: PRK00153 74547000104 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 74547000105 FAD binding domain; Region: FAD_binding_4; pfam01565 74547000106 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 74547000107 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 74547000108 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 74547000109 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 74547000110 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 74547000111 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK07403 74547000112 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 74547000113 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 74547000114 1 probable transmembrane helix predicted for by TMHMM2.0 74547000115 thiamine monophosphate kinase; Provisional; Region: PRK05731 74547000116 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 74547000117 ATP binding site [chemical binding]; other site 74547000118 dimerization interface [polypeptide binding]; other site 74547000119 cyclophilin_TLP40_like: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) similar ot the Spinach thylakoid lumen protein TLP40. Compared to the archetypal cyclophilin Human cyclophilin A, these proteins have similar peptidylprolyl...; Region: cyclophilin_TLP40_like; cd01924 74547000120 active site 74547000121 elongation factor P; Validated; Region: PRK00529 74547000122 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 74547000123 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 74547000124 RNA binding site [nucleotide binding]; other site 74547000125 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 74547000126 RNA binding site [nucleotide binding]; other site 74547000127 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 74547000128 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 74547000129 carboxyltransferase (CT) interaction site; other site 74547000130 biotinylation site [posttranslational modification]; other site 74547000131 4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK02746 74547000132 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 74547000133 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 74547000134 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 74547000135 putative NAD(P) binding site [chemical binding]; other site 74547000136 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 74547000137 active site 74547000138 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 74547000139 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 74547000140 ATP binding site [chemical binding]; other site 74547000141 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 74547000142 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 74547000143 ATP-binding site [chemical binding]; other site 74547000144 1 probable transmembrane helix predicted for by TMHMM2.0 74547000145 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 74547000146 4 probable transmembrane helices predicted by TMHMM2.0 74547000147 Transcriptional regulator [Transcription]; Region: LysR; COG0583 74547000148 1 probable transmembrane helix predicted for by TMHMM2.0 74547000149 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 74547000150 homodimer interface [polypeptide binding]; other site 74547000151 pyridoxal 5'-phosphate binding site [chemical binding]; other site 74547000152 catalytic residue [active] 74547000153 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 74547000154 GMP synthase; Reviewed; Region: guaA; PRK00074 74547000155 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 74547000156 AMP/PPi binding site [chemical binding]; other site 74547000157 candidate oxyanion hole; other site 74547000158 catalytic triad [active] 74547000159 potential glutamine specificity residues [chemical binding]; other site 74547000160 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 74547000161 ATP Binding subdomain [chemical binding]; other site 74547000162 Ligand Binding sites [chemical binding]; other site 74547000163 Dimerization subdomain; other site 74547000164 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 74547000165 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 74547000166 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 74547000167 1 probable transmembrane helix predicted for by TMHMM2.0 74547000168 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 74547000169 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 74547000170 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 74547000171 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 74547000172 NAD(P) binding site [chemical binding]; other site 74547000173 active site 74547000174 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 74547000175 ThiS interaction site; other site 74547000176 putative active site [active] 74547000177 tetramer interface [polypeptide binding]; other site 74547000178 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 74547000179 binding surface 74547000180 TPR motif; other site 74547000181 TPR repeat; Region: TPR_11; pfam13414 74547000182 1 probable transmembrane helix predicted for by TMHMM2.0 74547000183 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 74547000184 23S rRNA binding site [nucleotide binding]; other site 74547000185 L21 binding site [polypeptide binding]; other site 74547000186 L13 binding site [polypeptide binding]; other site 74547000187 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 74547000188 Stage II sporulation protein; Region: SpoIID; pfam08486 74547000189 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 74547000190 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 74547000191 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 74547000192 DXD motif; other site 74547000193 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 74547000194 5 probable transmembrane helices predicted by TMHMM2.0 74547000195 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14948 74547000196 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 74547000197 Walker A motif; other site 74547000198 ATP binding site [chemical binding]; other site 74547000199 Walker B motif; other site 74547000200 arginine finger; other site 74547000201 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 74547000202 Lecithin retinol acyltransferase; Region: LRAT; pfam04970 74547000203 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 74547000204 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 74547000205 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 74547000206 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 74547000207 Walker A motif; other site 74547000208 ATP binding site [chemical binding]; other site 74547000209 Walker B motif; other site 74547000210 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 74547000211 Clp protease; Region: CLP_protease; pfam00574 74547000212 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 74547000213 oligomer interface [polypeptide binding]; other site 74547000214 active site residues [active] 74547000215 trigger factor; Provisional; Region: tig; PRK01490 74547000216 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 74547000217 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 74547000218 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 74547000219 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 74547000220 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 74547000221 dihydrodipicolinate synthase; Region: dapA; TIGR00674 74547000222 dimer interface [polypeptide binding]; other site 74547000223 active site 74547000224 catalytic residue [active] 74547000225 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 74547000226 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 74547000227 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 74547000228 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 74547000229 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 74547000230 Ligand Binding Site [chemical binding]; other site 74547000231 TilS substrate binding domain; Region: TilS; pfam09179 74547000232 Protein of unknown function (DUF561); Region: DUF561; pfam04481 74547000233 Membrane protein of unknown function; Region: DUF360; pfam04020 74547000234 4 probable transmembrane helices predicted by TMHMM2.0 74547000235 excinuclease ABC subunit B; Provisional; Region: PRK05298 74547000236 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 74547000237 ATP binding site [chemical binding]; other site 74547000238 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 74547000239 nucleotide binding region [chemical binding]; other site 74547000240 ATP-binding site [chemical binding]; other site 74547000241 Ultra-violet resistance protein B; Region: UvrB; pfam12344 74547000242 UvrB/uvrC motif; Region: UVR; pfam02151 74547000243 aspartate kinase; Provisional; Region: PRK07431 74547000244 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 74547000245 putative nucleotide binding site [chemical binding]; other site 74547000246 putative catalytic residues [active] 74547000247 putative Mg ion binding site [ion binding]; other site 74547000248 putative aspartate binding site [chemical binding]; other site 74547000249 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 74547000250 putative allosteric regulatory site; other site 74547000251 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 74547000252 putative allosteric regulatory residue; other site 74547000253 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 74547000254 putative allosteric regulatory site; other site 74547000255 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 74547000256 putative allosteric regulatory residue; other site 74547000257 DNA polymerase III subunit delta; Validated; Region: PRK07452 74547000258 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 74547000259 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 74547000260 Precorrin-8X methylmutase; Region: CbiC; pfam02570 74547000261 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 74547000262 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 74547000263 HlyD family secretion protein; Region: HlyD_3; pfam13437 74547000264 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 74547000265 ligand binding site [chemical binding]; other site 74547000266 flexible hinge region; other site 74547000267 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 74547000268 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259 74547000269 putative active site [active] 74547000270 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 74547000271 ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249 74547000272 Walker A/P-loop; other site 74547000273 ATP binding site [chemical binding]; other site 74547000274 Q-loop/lid; other site 74547000275 ABC transporter signature motif; other site 74547000276 Walker B; other site 74547000277 D-loop; other site 74547000278 H-loop/switch region; other site 74547000279 5 probable transmembrane helices predicted by TMHMM2.0 74547000280 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 74547000281 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 74547000282 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 74547000283 MutS domain I; Region: MutS_I; pfam01624 74547000284 MutS domain II; Region: MutS_II; pfam05188 74547000285 MutS domain III; Region: MutS_III; pfam05192 74547000286 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 74547000287 Walker A/P-loop; other site 74547000288 ATP binding site [chemical binding]; other site 74547000289 Q-loop/lid; other site 74547000290 ABC transporter signature motif; other site 74547000291 Walker B; other site 74547000292 D-loop; other site 74547000293 H-loop/switch region; other site 74547000294 photosystem II core protein PsbZ; Region: PS_II_psbZ; TIGR03043 74547000295 2 probable transmembrane helices predicted by TMHMM2.0 74547000296 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 74547000297 homopentamer interface [polypeptide binding]; other site 74547000298 active site 74547000299 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 74547000300 Coenzyme A binding pocket [chemical binding]; other site 74547000301 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12902 74547000302 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 74547000303 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 74547000304 ATP binding site [chemical binding]; other site 74547000305 putative Mg++ binding site [ion binding]; other site 74547000306 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 74547000307 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 74547000308 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 74547000309 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 74547000310 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 74547000311 UDP-glucose 4-epimerase (G4E), subgroup 5, extended (e) SDRs; Region: UDP_G4E_5_SDR_e; cd05264 74547000312 putative NAD(P) binding site [chemical binding]; other site 74547000313 active site 74547000314 putative substrate binding site [chemical binding]; other site 74547000315 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 74547000316 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 74547000317 Rhamnan synthesis protein F; Region: RgpF; pfam05045 74547000318 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 74547000319 active site 74547000320 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 74547000321 10 probable transmembrane helices predicted by TMHMM2.0 74547000322 Protein of unknown function DUF115; Region: MAF_flag10; pfam01973 74547000323 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 74547000324 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 74547000325 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 74547000326 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 74547000327 Walker A/P-loop; other site 74547000328 ATP binding site [chemical binding]; other site 74547000329 Q-loop/lid; other site 74547000330 ABC transporter signature motif; other site 74547000331 Walker B; other site 74547000332 D-loop; other site 74547000333 H-loop/switch region; other site 74547000334 5 probable transmembrane helices predicted by TMHMM2.0 74547000335 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 74547000336 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 74547000337 HlyD family secretion protein; Region: HlyD_3; pfam13437 74547000338 1 probable transmembrane helix predicted for by TMHMM2.0 74547000339 UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589 74547000340 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 74547000341 NAD(P) binding site [chemical binding]; other site 74547000342 homodimer interface [polypeptide binding]; other site 74547000343 substrate binding site [chemical binding]; other site 74547000344 active site 74547000345 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 74547000346 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 74547000347 inhibitor-cofactor binding pocket; inhibition site 74547000348 pyridoxal 5'-phosphate binding site [chemical binding]; other site 74547000349 catalytic residue [active] 74547000350 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 74547000351 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 74547000352 active site 74547000353 catalytic tetrad [active] 74547000354 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_III; cd01996 74547000355 Ligand Binding Site [chemical binding]; other site 74547000356 Glutamine amidotransferase [Amino acid transport and metabolism]; Region: HisH; COG0118 74547000357 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 74547000358 putative active site [active] 74547000359 oxyanion strand; other site 74547000360 catalytic triad [active] 74547000361 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 74547000362 substrate binding site [chemical binding]; other site 74547000363 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 74547000364 glutamase interaction surface [polypeptide binding]; other site 74547000365 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 74547000366 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 74547000367 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 74547000368 ligand binding site; other site 74547000369 glutamate-1-semialdehyde 2,1-aminomutase; Provisional; Region: PRK06209 74547000370 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 74547000371 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 74547000372 catalytic residue [active] 74547000373 pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590 74547000374 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 74547000375 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 74547000376 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 74547000377 pseudaminic acid synthase; Region: PseI; TIGR03586 74547000378 NeuB family; Region: NeuB; pfam03102 74547000379 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 74547000380 NeuB binding interface [polypeptide binding]; other site 74547000381 putative substrate binding site [chemical binding]; other site 74547000382 Methyltransferase domain; Region: Methyltransf_24; pfam13578 74547000383 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 74547000384 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 74547000385 Walker A/P-loop; other site 74547000386 ATP binding site [chemical binding]; other site 74547000387 Q-loop/lid; other site 74547000388 ABC transporter signature motif; other site 74547000389 Walker B; other site 74547000390 D-loop; other site 74547000391 H-loop/switch region; other site 74547000392 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 74547000393 putative carbohydrate binding site [chemical binding]; other site 74547000394 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 74547000395 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 74547000396 5 probable transmembrane helices predicted by TMHMM2.0 74547000397 Methyltransferase domain; Region: Methyltransf_23; pfam13489 74547000398 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 74547000399 S-adenosylmethionine binding site [chemical binding]; other site 74547000400 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12902 74547000401 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 74547000402 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 74547000403 substrate binding site; other site 74547000404 tetramer interface; other site 74547000405 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 74547000406 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 74547000407 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 74547000408 NADP binding site [chemical binding]; other site 74547000409 active site 74547000410 putative substrate binding site [chemical binding]; other site 74547000411 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 74547000412 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 74547000413 NAD binding site [chemical binding]; other site 74547000414 substrate binding site [chemical binding]; other site 74547000415 homodimer interface [polypeptide binding]; other site 74547000416 active site 74547000417 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 74547000418 serine O-acetyltransferase; Region: cysE; TIGR01172 74547000419 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 74547000420 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 74547000421 trimer interface [polypeptide binding]; other site 74547000422 active site 74547000423 substrate binding site [chemical binding]; other site 74547000424 CoA binding site [chemical binding]; other site 74547000425 Predicted transcriptional regulators [Transcription]; Region: COG1725 74547000426 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 74547000427 DNA-binding site [nucleotide binding]; DNA binding site 74547000428 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 74547000429 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 74547000430 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 74547000431 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 74547000432 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 74547000433 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 74547000434 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 74547000435 Mg2+ binding site [ion binding]; other site 74547000436 G-X-G motif; other site 74547000437 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 74547000438 anchoring element; other site 74547000439 dimer interface [polypeptide binding]; other site 74547000440 ATP binding site [chemical binding]; other site 74547000441 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 74547000442 active site 74547000443 putative metal-binding site [ion binding]; other site 74547000444 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 74547000445 1 probable transmembrane helix predicted for by TMHMM2.0 74547000446 CrcB-like protein; Region: CRCB; pfam02537 74547000447 4 probable transmembrane helices predicted by TMHMM2.0 74547000448 CrcB-like protein; Region: CRCB; pfam02537 74547000449 3 probable transmembrane helices predicted by TMHMM2.0 74547000450 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 74547000451 catalytic residues [active] 74547000452 dimer interface [polypeptide binding]; other site 74547000453 Mg2+ transporter (mgtE); Region: mgtE; TIGR00400 74547000454 MgtE intracellular N domain; Region: MgtE_N; smart00924 74547000455 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 74547000456 Divalent cation transporter; Region: MgtE; pfam01769 74547000457 5 probable transmembrane helices predicted by TMHMM2.0 74547000458 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 74547000459 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 74547000460 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 74547000461 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 74547000462 Sigma-70, region 4; Region: Sigma70_r4; pfam04545 74547000463 DNA binding residues [nucleotide binding] 74547000464 hydrolase, alpha/beta fold family protein; Region: PLN02824 74547000465 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 74547000466 Protein export membrane protein; Region: SecD_SecF; cl14618 74547000467 14 probable transmembrane helices predicted by TMHMM2.0 74547000468 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 74547000469 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 74547000470 HlyD family secretion protein; Region: HlyD_3; pfam13437 74547000471 1 probable transmembrane helix predicted for by TMHMM2.0 74547000472 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 74547000473 putative Iron-sulfur protein interface [polypeptide binding]; other site 74547000474 proximal heme binding site [chemical binding]; other site 74547000475 distal heme binding site [chemical binding]; other site 74547000476 putative dimer interface [polypeptide binding]; other site 74547000477 5 probable transmembrane helices predicted by TMHMM2.0 74547000478 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 74547000479 L-aspartate oxidase; Provisional; Region: PRK06175 74547000480 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 74547000481 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 74547000482 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 74547000483 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 74547000484 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 74547000485 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 74547000486 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 74547000487 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 74547000488 minor groove reading motif; other site 74547000489 helix-hairpin-helix signature motif; other site 74547000490 substrate binding pocket [chemical binding]; other site 74547000491 active site 74547000492 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 74547000493 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 74547000494 active site 74547000495 8-oxo-dGMP binding site [chemical binding]; other site 74547000496 nudix motif; other site 74547000497 metal binding site [ion binding]; metal-binding site 74547000498 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 74547000499 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 74547000500 putative substrate binding site [chemical binding]; other site 74547000501 putative ATP binding site [chemical binding]; other site 74547000502 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 74547000503 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 74547000504 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 74547000505 homotetramer interface [polypeptide binding]; other site 74547000506 ligand binding site [chemical binding]; other site 74547000507 catalytic site [active] 74547000508 NAD binding site [chemical binding]; other site 74547000509 Glucosyl transferase GtrII; Region: Glucos_trans_II; pfam14264 74547000510 9 probable transmembrane helices predicted by TMHMM2.0 74547000511 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 74547000512 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 74547000513 3 probable transmembrane helices predicted by TMHMM2.0 74547000514 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 74547000515 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 74547000516 dimer interface [polypeptide binding]; other site 74547000517 ssDNA binding site [nucleotide binding]; other site 74547000518 tetramer (dimer of dimers) interface [polypeptide binding]; other site 74547000519 rod shape-determining protein MreB; Provisional; Region: PRK13927 74547000520 MreB and similar proteins; Region: MreB_like; cd10225 74547000521 nucleotide binding site [chemical binding]; other site 74547000522 Mg binding site [ion binding]; other site 74547000523 putative protofilament interaction site [polypeptide binding]; other site 74547000524 RodZ interaction site [polypeptide binding]; other site 74547000525 rod shape-determining protein MreC; Provisional; Region: PRK13922 74547000526 rod shape-determining protein MreC; Region: MreC; pfam04085 74547000527 4 probable transmembrane helices predicted by TMHMM2.0 74547000528 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 74547000529 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 74547000530 1 probable transmembrane helix predicted for by TMHMM2.0 74547000531 Ycf27; Reviewed; Region: orf27; CHL00148 74547000532 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 74547000533 active site 74547000534 phosphorylation site [posttranslational modification] 74547000535 intermolecular recognition site; other site 74547000536 dimerization interface [polypeptide binding]; other site 74547000537 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 74547000538 DNA binding site [nucleotide binding] 74547000539 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 74547000540 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 74547000541 dimer interface [polypeptide binding]; other site 74547000542 putative anticodon binding site; other site 74547000543 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 74547000544 motif 1; other site 74547000545 active site 74547000546 motif 2; other site 74547000547 motif 3; other site 74547000548 seryl-tRNA synthetase; Provisional; Region: PRK05431 74547000549 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 74547000550 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 74547000551 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 74547000552 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 74547000553 2 probable transmembrane helices predicted by TMHMM2.0 74547000554 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 74547000555 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 74547000556 active site 74547000557 ATP binding site [chemical binding]; other site 74547000558 substrate binding site [chemical binding]; other site 74547000559 activation loop (A-loop); other site 74547000560 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 74547000561 SmpB-tmRNA interface; other site 74547000562 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 74547000563 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 74547000564 Walker A motif; other site 74547000565 ATP binding site [chemical binding]; other site 74547000566 Walker B motif; other site 74547000567 arginine finger; other site 74547000568 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 74547000569 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 74547000570 TPR repeat; Region: TPR_11; pfam13414 74547000571 binding surface 74547000572 TPR motif; other site 74547000573 TPR repeat; Region: TPR_11; pfam13414 74547000574 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 74547000575 binding surface 74547000576 TPR motif; other site 74547000577 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 74547000578 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 74547000579 metal binding site [ion binding]; metal-binding site 74547000580 dimer interface [polypeptide binding]; other site 74547000581 Protein of unknown function (DUF3188); Region: DUF3188; pfam11384 74547000582 2 probable transmembrane helices predicted by TMHMM2.0 74547000583 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 74547000584 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 74547000585 Protein of unknown function (DUF1499); Region: DUF1499; pfam07386 74547000586 shikimate kinase; Reviewed; Region: aroK; PRK00131 74547000587 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 74547000588 ADP binding site [chemical binding]; other site 74547000589 magnesium binding site [ion binding]; other site 74547000590 putative shikimate binding site; other site 74547000591 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 74547000592 active site 74547000593 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 74547000594 active site 74547000595 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 74547000596 RibD C-terminal domain; Region: RibD_C; cl17279 74547000597 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 74547000598 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 74547000599 Protein of unknown function, DUF482; Region: DUF482; pfam04339 74547000600 Domain of unknown function (DUF4346); Region: DUF4346; pfam14251 74547000601 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 74547000602 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 74547000603 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 74547000604 FeS/SAM binding site; other site 74547000605 Domain of unknown function (DUF4070); Region: DUF4070; pfam13282 74547000606 Transmembrane secretion effector; Region: MFS_3; pfam05977 74547000607 12 probable transmembrane helices predicted by TMHMM2.0 74547000608 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 74547000609 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 74547000610 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 74547000611 FeS/SAM binding site; other site 74547000612 Vitamin K epoxide reductase family in bacteria and plants; Region: VKOR_1; cd12916 74547000613 substrate binding site [chemical binding]; other site 74547000614 putative active site [active] 74547000615 redox center [active] 74547000616 Protein Disulfide Isomerase (PDIa) family, redox active TRX domains; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family include PDI...; Region: PDI_a_family; cd02961 74547000617 catalytic residues [active] 74547000618 5 probable transmembrane helices predicted by TMHMM2.0 74547000619 L-aspartate oxidase; Provisional; Region: PRK07395 74547000620 L-aspartate oxidase; Provisional; Region: PRK06175 74547000621 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 74547000622 photosystem II complex extrinsic protein precursor U; Provisional; Region: psbU; PRK02515 74547000623 1 probable transmembrane helix predicted for by TMHMM2.0 74547000624 Protein of unknown function (DUF3120); Region: DUF3120; pfam11318 74547000625 7 probable transmembrane helices predicted by TMHMM2.0 74547000626 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 74547000627 6 probable transmembrane helices predicted by TMHMM2.0 74547000628 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cd00136 74547000629 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 74547000630 Protein of unknown function (DUF512); Region: DUF512; pfam04459 74547000631 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 74547000632 Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643 74547000633 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 74547000634 active site 74547000635 Predicted enolase-phosphatase [Energy production and conversion]; Region: COG4229 74547000636 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 74547000637 active site 74547000638 motif I; other site 74547000639 motif II; other site 74547000640 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 74547000641 intersubunit interface [polypeptide binding]; other site 74547000642 active site 74547000643 Zn2+ binding site [ion binding]; other site 74547000644 formamidopyrimidine-DNA glycosylase; Provisional; Region: PRK13945 74547000645 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 74547000646 DNA binding site [nucleotide binding] 74547000647 catalytic residue [active] 74547000648 H2TH interface [polypeptide binding]; other site 74547000649 putative catalytic residues [active] 74547000650 turnover-facilitating residue; other site 74547000651 intercalation triad [nucleotide binding]; other site 74547000652 8OG recognition residue [nucleotide binding]; other site 74547000653 putative reading head residues; other site 74547000654 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 74547000655 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 74547000656 photosystem I reaction center subunit IV; Provisional; Region: PRK02749 74547000657 ATP-dependent DNA helicase, RecQ family; Region: recQ_fam; TIGR00614 74547000658 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 74547000659 ATP binding site [chemical binding]; other site 74547000660 putative Mg++ binding site [ion binding]; other site 74547000661 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 74547000662 nucleotide binding region [chemical binding]; other site 74547000663 ATP-binding site [chemical binding]; other site 74547000664 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 74547000665 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 74547000666 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 74547000667 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 74547000668 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 74547000669 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 74547000670 4 probable transmembrane helices predicted by TMHMM2.0 74547000671 1 probable transmembrane helix predicted for by TMHMM2.0 74547000672 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 74547000673 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 74547000674 NAD(P) binding site [chemical binding]; other site 74547000675 catalytic residues [active] 74547000676 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 74547000677 active site 74547000678 homodimer interface [polypeptide binding]; other site 74547000679 catalytic site [active] 74547000680 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 74547000681 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 74547000682 9 probable transmembrane helices predicted by TMHMM2.0 74547000683 Protein of unknown function (DUF1651); Region: DUF1651; pfam07864 74547000684 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 74547000685 Dehydroquinase class II; Region: DHquinase_II; pfam01220 74547000686 active site 74547000687 trimer interface [polypeptide binding]; other site 74547000688 dimer interface [polypeptide binding]; other site 74547000689 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 74547000690 active site 74547000691 dinuclear metal binding site [ion binding]; other site 74547000692 dimerization interface [polypeptide binding]; other site 74547000693 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 74547000694 Cupin domain; Region: Cupin_2; cl17218 74547000695 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 74547000696 active site 74547000697 SAM binding site [chemical binding]; other site 74547000698 homodimer interface [polypeptide binding]; other site 74547000699 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 74547000700 6 probable transmembrane helices predicted by TMHMM2.0 74547000701 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 74547000702 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 74547000703 FMN binding site [chemical binding]; other site 74547000704 active site 74547000705 catalytic residues [active] 74547000706 substrate binding site [chemical binding]; other site 74547000707 Domain of unknown function (DUF1824); Region: DUF1824; pfam08854 74547000708 Domain of unknown function (DUF1823); Region: DUF1823; pfam08853 74547000709 GTP-binding protein Der; Reviewed; Region: PRK00093 74547000710 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 74547000711 G1 box; other site 74547000712 GTP/Mg2+ binding site [chemical binding]; other site 74547000713 Switch I region; other site 74547000714 G2 box; other site 74547000715 Switch II region; other site 74547000716 G3 box; other site 74547000717 G4 box; other site 74547000718 G5 box; other site 74547000719 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 74547000720 G1 box; other site 74547000721 GTP/Mg2+ binding site [chemical binding]; other site 74547000722 Switch I region; other site 74547000723 G2 box; other site 74547000724 G3 box; other site 74547000725 Switch II region; other site 74547000726 G4 box; other site 74547000727 G5 box; other site 74547000728 Cobalt transport protein; Region: CbiQ; cl00463 74547000729 5 probable transmembrane helices predicted by TMHMM2.0 74547000730 Protein of unknown function (DUF3539); Region: DUF3539; pfam12058 74547000731 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 74547000732 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 74547000733 catalytic residue [active] 74547000734 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 74547000735 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 74547000736 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 74547000737 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 74547000738 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 74547000739 H+ Antiporter protein; Region: 2A0121; TIGR00900 74547000740 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 74547000741 putative substrate translocation pore; other site 74547000742 10 probable transmembrane helices predicted by TMHMM2.0 74547000743 Recombination protein O N terminal; Region: RecO_N; pfam11967 74547000744 Recombination protein O C terminal; Region: RecO_C; pfam02565 74547000745 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 74547000746 intersubunit interface [polypeptide binding]; other site 74547000747 active site 74547000748 catalytic residue [active] 74547000749 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 74547000750 30S subunit binding site; other site 74547000751 lipoate-protein ligase B; Provisional; Region: PRK14344 74547000752 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 74547000753 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 74547000754 acyl-activating enzyme (AAE) consensus motif; other site 74547000755 putative AMP binding site [chemical binding]; other site 74547000756 putative active site [active] 74547000757 putative CoA binding site [chemical binding]; other site 74547000758 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 74547000759 Ion transport protein; Region: Ion_trans; pfam00520 74547000760 Ion channel; Region: Ion_trans_2; pfam07885 74547000761 6 probable transmembrane helices predicted by TMHMM2.0 74547000762 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 74547000763 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 74547000764 E3 interaction surface; other site 74547000765 lipoyl attachment site [posttranslational modification]; other site 74547000766 e3 binding domain; Region: E3_binding; pfam02817 74547000767 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 74547000768 NHL repeat; Region: NHL; pfam01436 74547000769 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 74547000770 10 probable transmembrane helices predicted by TMHMM2.0 74547000771 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 74547000772 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 74547000773 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 74547000774 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 74547000775 dimer interface [polypeptide binding]; other site 74547000776 pyridoxal 5'-phosphate binding site [chemical binding]; other site 74547000777 catalytic residue [active] 74547000778 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 74547000779 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 74547000780 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 74547000781 catalytic residue [active] 74547000782 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 74547000783 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 74547000784 homodimer interface [polypeptide binding]; other site 74547000785 substrate-cofactor binding pocket; other site 74547000786 pyridoxal 5'-phosphate binding site [chemical binding]; other site 74547000787 catalytic residue [active] 74547000788 ribosomal protein S4; Reviewed; Region: rps4; CHL00113 74547000789 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 74547000790 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 74547000791 RNA binding surface [nucleotide binding]; other site 74547000792 Haemolytic domain; Region: Haemolytic; pfam01809 74547000793 1 probable transmembrane helix predicted for by TMHMM2.0 74547000794 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 74547000795 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 74547000796 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 74547000797 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 74547000798 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 74547000799 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 74547000800 7 probable transmembrane helices predicted by TMHMM2.0 74547000801 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 74547000802 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 74547000803 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 74547000804 catalytic residue [active] 74547000805 integron integrase; Region: integrase_gron; TIGR02249 74547000806 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 74547000807 active site 74547000808 catalytic residues [active] 74547000809 DNA binding site [nucleotide binding] 74547000810 Int/Topo IB signature motif; other site 74547000811 nif11-like leader peptide domain; Region: ocin_TIGR03798 74547000812 nif11-like leader peptide domain; Region: ocin_TIGR03798 74547000813 nif11-like leader peptide domain; Region: ocin_TIGR03798 74547000814 nif11-like leader peptide domain; Region: ocin_TIGR03798 74547000815 nif11-like leader peptide domain; Region: ocin_TIGR03798 74547000816 nif11-like leader peptide domain; Region: ocin_TIGR03798 74547000817 nif11-like leader peptide domain; Region: ocin_TIGR03798 74547000818 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 74547000819 Fatty acid desaturase; Region: FA_desaturase; pfam00487 74547000820 putative di-iron ligands [ion binding]; other site 74547000821 4 probable transmembrane helices predicted by TMHMM2.0 74547000822 type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897 74547000823 LanM-like proteins. LanM is a bifunctional enzyme, involved in the synthesis of class II lantibiotics. It is responsible for both the dehydration and the cyclization of the precursor-peptide during lantibiotic synthesis. The C-terminal domain shows...; Region: LanM-like; cd04792 74547000824 active site 74547000825 zinc binding site [ion binding]; other site 74547000826 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 74547000827 Protein of unknown function (DUF3137); Region: DUF3137; pfam11335 74547000828 2 probable transmembrane helices predicted by TMHMM2.0 74547000829 NifU-like domain; Region: NifU; pfam01106 74547000830 malate:quinone oxidoreductase; Validated; Region: PRK05257 74547000831 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 74547000832 C-type lectin (CTL)/C-type lectin-like (CTLD) domain; Region: CLECT; cl02432 74547000833 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cd00636 74547000834 intersubunit interface [polypeptide binding]; other site 74547000835 GTP-binding protein LepA; Provisional; Region: PRK05433 74547000836 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 74547000837 G1 box; other site 74547000838 putative GEF interaction site [polypeptide binding]; other site 74547000839 GTP/Mg2+ binding site [chemical binding]; other site 74547000840 Switch I region; other site 74547000841 G2 box; other site 74547000842 G3 box; other site 74547000843 Switch II region; other site 74547000844 G4 box; other site 74547000845 G5 box; other site 74547000846 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 74547000847 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 74547000848 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 74547000849 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 74547000850 metal ion-dependent adhesion site (MIDAS); other site 74547000851 1 probable transmembrane helix predicted for by TMHMM2.0 74547000852 1 probable transmembrane helix predicted for by TMHMM2.0 74547000853 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 74547000854 Prokaryotic N-terminal methylation site; Region: N_methyl_3; pfam13633 74547000855 1 probable transmembrane helix predicted for by TMHMM2.0 74547000856 1 probable transmembrane helix predicted for by TMHMM2.0 74547000857 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 74547000858 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 74547000859 1 probable transmembrane helix predicted for by TMHMM2.0 74547000860 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 74547000861 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 74547000862 1 probable transmembrane helix predicted for by TMHMM2.0 74547000863 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 74547000864 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 74547000865 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 74547000866 dimer interface [polypeptide binding]; other site 74547000867 phosphorylation site [posttranslational modification] 74547000868 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 74547000869 ATP binding site [chemical binding]; other site 74547000870 Mg2+ binding site [ion binding]; other site 74547000871 G-X-G motif; other site 74547000872 2 probable transmembrane helices predicted by TMHMM2.0 74547000873 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 74547000874 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 74547000875 ABC-ATPase subunit interface; other site 74547000876 6 probable transmembrane helices predicted by TMHMM2.0 74547000877 2 probable transmembrane helices predicted by TMHMM2.0 74547000878 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 74547000879 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 74547000880 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 74547000881 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 74547000882 DNA binding site [nucleotide binding] 74547000883 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 74547000884 active site 74547000885 16S rRNA methyltransferase B; Provisional; Region: PRK14901 74547000886 NusB family; Region: NusB; pfam01029 74547000887 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 74547000888 S-adenosylmethionine binding site [chemical binding]; other site 74547000889 Transglycosylase; Region: Transgly; pfam00912 74547000890 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 74547000891 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 74547000892 1 probable transmembrane helix predicted for by TMHMM2.0 74547000893 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 74547000894 UbiA prenyltransferase family; Region: UbiA; pfam01040 74547000895 8 probable transmembrane helices predicted by TMHMM2.0 74547000896 Protein of unknown function (DUF2862); Region: DUF2862; pfam11061 74547000897 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 74547000898 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 74547000899 substrate binding site [chemical binding]; other site 74547000900 glutamase interaction surface [polypeptide binding]; other site 74547000901 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 74547000902 S-adenosylmethionine binding site [chemical binding]; other site 74547000903 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 74547000904 L-aspartate oxidase; Provisional; Region: PRK07395 74547000905 TPR repeat; Region: TPR_11; pfam13414 74547000906 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 74547000907 binding surface 74547000908 TPR motif; other site 74547000909 TPR repeat; Region: TPR_11; pfam13414 74547000910 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 74547000911 binding surface 74547000912 TPR motif; other site 74547000913 Tetratricopeptide repeat; Region: TPR_12; pfam13424 74547000914 TPR repeat; Region: TPR_11; pfam13414 74547000915 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 74547000916 binding surface 74547000917 TPR motif; other site 74547000918 TPR repeat; Region: TPR_11; pfam13414 74547000919 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 74547000920 Methyltransferase domain; Region: Methyltransf_31; pfam13847 74547000921 S-adenosylmethionine binding site [chemical binding]; other site 74547000922 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 74547000923 3 probable transmembrane helices predicted by TMHMM2.0 74547000924 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 74547000925 dimer interface [polypeptide binding]; other site 74547000926 motif 1; other site 74547000927 active site 74547000928 motif 2; other site 74547000929 motif 3; other site 74547000930 S-layer homology domain; Region: SLH; pfam00395 74547000931 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 74547000932 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 74547000933 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 74547000934 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 74547000935 2 probable transmembrane helices predicted by TMHMM2.0 74547000936 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 74547000937 Competence protein; Region: Competence; pfam03772 74547000938 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 74547000939 active site 74547000940 Int/Topo IB signature motif; other site 74547000941 multiple promoter invertase; Provisional; Region: mpi; PRK13413 74547000942 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 74547000943 catalytic residues [active] 74547000944 catalytic nucleophile [active] 74547000945 Presynaptic Site I dimer interface [polypeptide binding]; other site 74547000946 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 74547000947 Synaptic Flat tetramer interface [polypeptide binding]; other site 74547000948 Synaptic Site I dimer interface [polypeptide binding]; other site 74547000949 DNA binding site [nucleotide binding] 74547000950 TPR repeat; Region: TPR_11; pfam13414 74547000951 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 74547000952 binding surface 74547000953 TPR motif; other site 74547000954 TPR repeat; Region: TPR_11; pfam13414 74547000955 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 74547000956 binding surface 74547000957 TPR motif; other site 74547000958 TPR repeat; Region: TPR_11; pfam13414 74547000959 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 74547000960 binding surface 74547000961 TPR motif; other site 74547000962 TPR repeat; Region: TPR_11; pfam13414 74547000963 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 74547000964 binding surface 74547000965 TPR motif; other site 74547000966 TPR repeat; Region: TPR_11; pfam13414 74547000967 TPR repeat; Region: TPR_11; pfam13414 74547000968 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 74547000969 binding surface 74547000970 TPR motif; other site 74547000971 TPR repeat; Region: TPR_11; pfam13414 74547000972 TPR repeat; Region: TPR_11; pfam13414 74547000973 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 74547000974 binding surface 74547000975 TPR motif; other site 74547000976 TPR repeat; Region: TPR_11; pfam13414 74547000977 1 probable transmembrane helix predicted for by TMHMM2.0 74547000978 TPR repeat; Region: TPR_11; pfam13414 74547000979 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 74547000980 binding surface 74547000981 TPR motif; other site 74547000982 TPR repeat; Region: TPR_11; pfam13414 74547000983 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 74547000984 binding surface 74547000985 TPR motif; other site 74547000986 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 74547000987 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 74547000988 binding surface 74547000989 TPR motif; other site 74547000990 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 74547000991 binding surface 74547000992 TPR motif; other site 74547000993 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 74547000994 TPR motif; other site 74547000995 binding surface 74547000996 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 74547000997 binding surface 74547000998 TPR motif; other site 74547000999 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 74547001000 binding surface 74547001001 TPR motif; other site 74547001002 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 74547001003 binding surface 74547001004 TPR motif; other site 74547001005 Tetratricopeptide repeat; Region: TPR_1; pfam00515 74547001006 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 74547001007 binding surface 74547001008 TPR motif; other site 74547001009 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 74547001010 binding surface 74547001011 TPR motif; other site 74547001012 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 74547001013 binding surface 74547001014 TPR motif; other site 74547001015 1 probable transmembrane helix predicted for by TMHMM2.0 74547001016 Staphylococcal nuclease homologues; Region: SNc; smart00318 74547001017 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 74547001018 Catalytic site; other site 74547001019 TPR repeat; Region: TPR_11; pfam13414 74547001020 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 74547001021 binding surface 74547001022 TPR motif; other site 74547001023 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 74547001024 binding surface 74547001025 TPR motif; other site 74547001026 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 74547001027 TPR repeat; Region: TPR_11; pfam13414 74547001028 binding surface 74547001029 TPR motif; other site 74547001030 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 74547001031 binding surface 74547001032 TPR repeat; Region: TPR_11; pfam13414 74547001033 TPR motif; other site 74547001034 TPR repeat; Region: TPR_11; pfam13414 74547001035 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 74547001036 binding surface 74547001037 TPR motif; other site 74547001038 TPR repeat; Region: TPR_11; pfam13414 74547001039 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 74547001040 TPR repeat; Region: TPR_11; pfam13414 74547001041 binding surface 74547001042 TPR motif; other site 74547001043 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 74547001044 Walker A motif; other site 74547001045 ATP binding site [chemical binding]; other site 74547001046 Walker B motif; other site 74547001047 AAA domain; Region: AAA_11; pfam13086 74547001048 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 74547001049 AAA domain; Region: AAA_12; pfam13087 74547001050 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 74547001051 putative active site [active] 74547001052 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 74547001053 6 probable transmembrane helices predicted by TMHMM2.0 74547001054 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 74547001055 5-oxoprolinase; Region: PLN02666 74547001056 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 74547001057 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 74547001058 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 74547001059 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 74547001060 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 74547001061 putative ADP-binding pocket [chemical binding]; other site 74547001062 Bacterial sugar transferase; Region: Bac_transf; pfam02397 74547001063 1 probable transmembrane helix predicted for by TMHMM2.0 74547001064 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 74547001065 2 probable transmembrane helices predicted by TMHMM2.0 74547001066 ketol-acid reductoisomerase; Provisional; Region: PRK05479 74547001067 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 74547001068 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 74547001069 Clp protease; Region: CLP_protease; pfam00574 74547001070 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 74547001071 oligomer interface [polypeptide binding]; other site 74547001072 active site residues [active] 74547001073 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 74547001074 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 74547001075 oligomer interface [polypeptide binding]; other site 74547001076 active site residues [active] 74547001077 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 74547001078 putative active site [active] 74547001079 3 probable transmembrane helices predicted by TMHMM2.0 74547001080 coproporphyrinogen III oxidase; Provisional; Region: PRK07379 74547001081 HemN C-terminal domain; Region: HemN_C; pfam06969 74547001082 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 74547001083 oligomerization interface [polypeptide binding]; other site 74547001084 active site 74547001085 metal binding site [ion binding]; metal-binding site 74547001086 cell division protein FtsZ; Validated; Region: PRK09330 74547001087 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 74547001088 nucleotide binding site [chemical binding]; other site 74547001089 SulA interaction site; other site 74547001090 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 74547001091 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 74547001092 1 probable transmembrane helix predicted for by TMHMM2.0 74547001093 1 probable transmembrane helix predicted for by TMHMM2.0 74547001094 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 74547001095 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 74547001096 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 74547001097 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14333 74547001098 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 74547001099 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 74547001100 FeS/SAM binding site; other site 74547001101 TRAM domain; Region: TRAM; cl01282 74547001102 Domain of unknown function (DUF4359); Region: DUF4359; pfam14271 74547001103 cytosine deaminase-like protein; Validated; Region: PRK07583 74547001104 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 74547001105 active site 74547001106 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 74547001107 FAD binding domain; Region: FAD_binding_4; pfam01565 74547001108 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 74547001109 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 74547001110 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 74547001111 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 74547001112 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 74547001113 acetylornithine aminotransferase; Provisional; Region: PRK02627 74547001114 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 74547001115 inhibitor-cofactor binding pocket; inhibition site 74547001116 pyridoxal 5'-phosphate binding site [chemical binding]; other site 74547001117 catalytic residue [active] 74547001118 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 74547001119 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 74547001120 hinge; other site 74547001121 active site 74547001122 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 74547001123 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 74547001124 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 74547001125 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 74547001126 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 74547001127 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 74547001128 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 74547001129 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 74547001130 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 74547001131 active site 74547001132 ribulose/triose binding site [chemical binding]; other site 74547001133 phosphate binding site [ion binding]; other site 74547001134 substrate (anthranilate) binding pocket [chemical binding]; other site 74547001135 product (indole) binding pocket [chemical binding]; other site 74547001136 6 probable transmembrane helices predicted by TMHMM2.0 74547001137 High-affinity nickel-transport protein; Region: NicO; cl00964 74547001138 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 74547001139 Catalytic site [active] 74547001140 Nickel-containing superoxide dismutase; Region: Sod_Ni; cl07609 74547001141 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 74547001142 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 74547001143 1 probable transmembrane helix predicted for by TMHMM2.0 74547001144 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 74547001145 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 74547001146 putative active site [active] 74547001147 catalytic triad [active] 74547001148 putative dimer interface [polypeptide binding]; other site 74547001149 6 probable transmembrane helices predicted by TMHMM2.0 74547001150 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 74547001151 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 74547001152 Uncharacterized conserved protein [Function unknown]; Region: COG0062 74547001153 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 74547001154 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 74547001155 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 74547001156 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 74547001157 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 74547001158 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 74547001159 DNA binding residues [nucleotide binding] 74547001160 pyruvate dehydrogenase E1 component alpha subunit; Reviewed; Region: odpA; CHL00149 74547001161 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 74547001162 tetramer interface [polypeptide binding]; other site 74547001163 TPP-binding site [chemical binding]; other site 74547001164 heterodimer interface [polypeptide binding]; other site 74547001165 phosphorylation loop region [posttranslational modification] 74547001166 DnaJ domain; Region: DnaJ; pfam00226 74547001167 Protein of unknown function (DUF4101); Region: DUF4101; pfam13355 74547001168 1 probable transmembrane helix predicted for by TMHMM2.0 74547001169 signal recognition particle protein; Provisional; Region: PRK10867 74547001170 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 74547001171 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 74547001172 P loop; other site 74547001173 GTP binding site [chemical binding]; other site 74547001174 Signal peptide binding domain; Region: SRP_SPB; pfam02978 74547001175 ribosomal protein S16; Region: rps16; CHL00005 74547001176 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 74547001177 PhoH-like protein; Region: PhoH; pfam02562 74547001178 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 74547001179 7 probable transmembrane helices predicted by TMHMM2.0 74547001180 9 probable transmembrane helices predicted by TMHMM2.0 74547001181 GTPase Era; Reviewed; Region: era; PRK00089 74547001182 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 74547001183 G1 box; other site 74547001184 GTP/Mg2+ binding site [chemical binding]; other site 74547001185 Switch I region; other site 74547001186 G2 box; other site 74547001187 Switch II region; other site 74547001188 G3 box; other site 74547001189 G4 box; other site 74547001190 G5 box; other site 74547001191 KH domain; Region: KH_2; pfam07650 74547001192 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 74547001193 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 74547001194 homotrimer interaction site [polypeptide binding]; other site 74547001195 zinc binding site [ion binding]; other site 74547001196 CDP-binding sites; other site 74547001197 uncharacterized cyanobacterial protein, TIGR03792 family; Region: TIGR03792 74547001198 AIR carboxylase; Region: AIRC; smart01001 74547001199 Protein of unknown function (DUF1517); Region: DUF1517; cl01807 74547001200 Protein of unknown function (DUF1517); Region: DUF1517; pfam07466 74547001201 2 probable transmembrane helices predicted by TMHMM2.0 74547001202 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 74547001203 thiS-thiF/thiG interaction site; other site 74547001204 thiamine-phosphate pyrophosphorylase; Provisional; Region: PRK02615 74547001205 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 74547001206 thiamine phosphate binding site [chemical binding]; other site 74547001207 active site 74547001208 pyrophosphate binding site [ion binding]; other site 74547001209 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 74547001210 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 74547001211 active site 74547001212 Riboflavin kinase; Region: Flavokinase; smart00904 74547001213 Protein of unknown function (DUF3611); Region: DUF3611; pfam12263 74547001214 4 probable transmembrane helices predicted by TMHMM2.0 74547001215 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 74547001216 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 74547001217 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 74547001218 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 74547001219 dimer interface [polypeptide binding]; other site 74547001220 motif 1; other site 74547001221 active site 74547001222 motif 2; other site 74547001223 motif 3; other site 74547001224 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02649 74547001225 ATP-NAD kinase; Region: NAD_kinase; pfam01513 74547001226 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 74547001227 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 74547001228 active site 74547001229 SAM binding site [chemical binding]; other site 74547001230 putative homodimer interface [polypeptide binding]; other site 74547001231 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 74547001232 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 74547001233 Predicted bile acid beta-glucosidase [Carbohydrate transport and metabolism]; Region: COG4354 74547001234 beta-Glucocerebrosidase 2 N terminal; Region: GBA2_N; pfam12215 74547001235 Protein of unknown function, DUF608; Region: DUF608; pfam04685 74547001236 Protein of unknown function (DUF3122); Region: DUF3122; pfam11320 74547001237 1 probable transmembrane helix predicted for by TMHMM2.0 74547001238 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 74547001239 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 74547001240 catalytic motif [active] 74547001241 Zn binding site [ion binding]; other site 74547001242 RibD C-terminal domain; Region: RibD_C; cl17279 74547001243 Ion channel; Region: Ion_trans_2; pfam07885 74547001244 4 probable transmembrane helices predicted by TMHMM2.0 74547001245 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 74547001246 FtsH Extracellular; Region: FtsH_ext; pfam06480 74547001247 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 74547001248 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 74547001249 Walker A motif; other site 74547001250 ATP binding site [chemical binding]; other site 74547001251 Walker B motif; other site 74547001252 arginine finger; other site 74547001253 Peptidase family M41; Region: Peptidase_M41; pfam01434 74547001254 2 probable transmembrane helices predicted by TMHMM2.0 74547001255 ornithine carbamoyltransferase; Provisional; Region: PRK00779 74547001256 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 74547001257 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 74547001258 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 74547001259 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 74547001260 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 74547001261 Catalytic site [active] 74547001262 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 74547001263 2 probable transmembrane helices predicted by TMHMM2.0 74547001264 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 74547001265 active site 74547001266 catalytic residues [active] 74547001267 metal binding site [ion binding]; metal-binding site 74547001268 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 74547001269 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 74547001270 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 74547001271 active site 74547001272 catalytic site [active] 74547001273 substrate binding site [chemical binding]; other site 74547001274 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 74547001275 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 74547001276 catalytic triad [active] 74547001277 Protein of unknown function (DUF1350); Region: DUF1350; pfam07082 74547001278 1 probable transmembrane helix predicted for by TMHMM2.0 74547001279 acetyl-CoA synthetase; Provisional; Region: PRK00174 74547001280 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 74547001281 active site 74547001282 CoA binding site [chemical binding]; other site 74547001283 acyl-activating enzyme (AAE) consensus motif; other site 74547001284 AMP binding site [chemical binding]; other site 74547001285 acetate binding site [chemical binding]; other site 74547001286 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 74547001287 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 74547001288 motif II; other site 74547001289 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 74547001290 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 74547001291 substrate binding pocket [chemical binding]; other site 74547001292 chain length determination region; other site 74547001293 substrate-Mg2+ binding site; other site 74547001294 catalytic residues [active] 74547001295 aspartate-rich region 1; other site 74547001296 active site lid residues [active] 74547001297 aspartate-rich region 2; other site 74547001298 glutamate racemase; Provisional; Region: PRK00865 74547001299 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 74547001300 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 74547001301 active site 74547001302 metal binding site [ion binding]; metal-binding site 74547001303 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 74547001304 nitrilase; Region: PLN02798 74547001305 putative active site [active] 74547001306 catalytic triad [active] 74547001307 dimer interface [polypeptide binding]; other site 74547001308 2-phosphosulfolactate phosphatase; Provisional; Region: PRK00886 74547001309 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 74547001310 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 74547001311 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 74547001312 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 74547001313 hinge; other site 74547001314 active site 74547001315 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 74547001316 S-adenosylmethionine binding site [chemical binding]; other site 74547001317 S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; cl17711 74547001318 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14360 74547001319 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 74547001320 Substrate binding site; other site 74547001321 Mg++ binding site; other site 74547001322 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 74547001323 active site 74547001324 substrate binding site [chemical binding]; other site 74547001325 CoA binding site [chemical binding]; other site 74547001326 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 74547001327 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 74547001328 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 74547001329 1 probable transmembrane helix predicted for by TMHMM2.0 74547001330 glycogen synthase; Provisional; Region: glgA; PRK00654 74547001331 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 74547001332 ADP-binding pocket [chemical binding]; other site 74547001333 homodimer interface [polypeptide binding]; other site 74547001334 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 74547001335 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 74547001336 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 74547001337 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 74547001338 substrate binding site [chemical binding]; other site 74547001339 oxyanion hole (OAH) forming residues; other site 74547001340 trimer interface [polypeptide binding]; other site 74547001341 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 74547001342 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 74547001343 dimer interface [polypeptide binding]; other site 74547001344 tetramer interface [polypeptide binding]; other site 74547001345 PYR/PP interface [polypeptide binding]; other site 74547001346 TPP binding site [chemical binding]; other site 74547001347 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 74547001348 TPP-binding site; other site 74547001349 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 74547001350 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 74547001351 Catalytic site [active] 74547001352 Protein of unknown function (DUF760); Region: DUF760; pfam05542 74547001353 Domain of unknown function (DUF4336); Region: DUF4336; pfam14234 74547001354 Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862 74547001355 1 probable transmembrane helix predicted for by TMHMM2.0 74547001356 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 74547001357 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 74547001358 malonyl-CoA binding site [chemical binding]; other site 74547001359 dimer interface [polypeptide binding]; other site 74547001360 active site 74547001361 product binding site; other site 74547001362 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 74547001363 Methyltransferase domain; Region: Methyltransf_31; pfam13847 74547001364 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 74547001365 S-adenosylmethionine binding site [chemical binding]; other site 74547001366 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 74547001367 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 74547001368 ABC-ATPase subunit interface; other site 74547001369 dimer interface [polypeptide binding]; other site 74547001370 putative PBP binding regions; other site 74547001371 8 probable transmembrane helices predicted by TMHMM2.0 74547001372 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 74547001373 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 74547001374 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 74547001375 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 74547001376 metal binding site [ion binding]; metal-binding site 74547001377 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 74547001378 protein I interface; other site 74547001379 D2 interface; other site 74547001380 protein T interface; other site 74547001381 chlorophyll binding site; other site 74547001382 beta carotene binding site; other site 74547001383 pheophytin binding site; other site 74547001384 manganese-stabilizing polypeptide interface; other site 74547001385 CP43 interface; other site 74547001386 protein L interface; other site 74547001387 oxygen evolving complex binding site; other site 74547001388 bromide binding site; other site 74547001389 quinone binding site; other site 74547001390 Fe binding site [ion binding]; other site 74547001391 core light harvesting interface; other site 74547001392 cytochrome b559 alpha subunit interface; other site 74547001393 cytochrome c-550 interface; other site 74547001394 protein J interface; other site 74547001395 5 probable transmembrane helices predicted by TMHMM2.0 74547001396 Domain of unknown function (DUF697); Region: DUF697; pfam05128 74547001397 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 74547001398 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 74547001399 active site 74547001400 HIGH motif; other site 74547001401 dimer interface [polypeptide binding]; other site 74547001402 KMSKS motif; other site 74547001403 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 74547001404 catalytic residue [active] 74547001405 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 74547001406 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 74547001407 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 74547001408 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 74547001409 active site 74547001410 dimer interface [polypeptide binding]; other site 74547001411 motif 1; other site 74547001412 motif 2; other site 74547001413 motif 3; other site 74547001414 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 74547001415 anticodon binding site; other site 74547001416 glucokinase, proteobacterial type; Region: glk; TIGR00749 74547001417 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 74547001418 nucleotide binding site [chemical binding]; other site 74547001419 homoserine kinase; Provisional; Region: PRK01212 74547001420 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 74547001421 NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK12561 74547001422 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 74547001423 12 probable transmembrane helices predicted by TMHMM2.0 74547001424 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 74547001425 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 74547001426 active site 74547001427 Zn binding site [ion binding]; other site 74547001428 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 74547001429 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 74547001430 14 probable transmembrane helices predicted by TMHMM2.0 74547001431 2 probable transmembrane helices predicted by TMHMM2.0 74547001432 5 probable transmembrane helices predicted by TMHMM2.0 74547001433 7 probable transmembrane helices predicted by TMHMM2.0 74547001434 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 74547001435 Dihydroneopterin aldolase; Region: FolB; smart00905 74547001436 active site 74547001437 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 74547001438 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 74547001439 putative catalytic cysteine [active] 74547001440 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 74547001441 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 74547001442 nucleotide binding site [chemical binding]; other site 74547001443 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 74547001444 Family of unknown function (DUF490); Region: DUF490; pfam04357 74547001445 Protein of function (DUF2518); Region: DUF2518; pfam10726 74547001446 2 probable transmembrane helices predicted by TMHMM2.0 74547001447 Domain of unknown function (DUF4332); Region: DUF4332; pfam14229 74547001448 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 74547001449 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 74547001450 1 probable transmembrane helix predicted for by TMHMM2.0 74547001451 glycogen branching enzyme; Provisional; Region: PRK05402 74547001452 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 74547001453 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 74547001454 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 74547001455 active site 74547001456 catalytic site [active] 74547001457 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 74547001458 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 74547001459 substrate binding site [chemical binding]; other site 74547001460 active site 74547001461 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 74547001462 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 74547001463 NAD(P) binding site [chemical binding]; other site 74547001464 active site 74547001465 plastocyanin; Provisional; Region: PRK02710 74547001466 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 74547001467 1 probable transmembrane helix predicted for by TMHMM2.0 74547001468 Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862 74547001469 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 74547001470 Clp amino terminal domain; Region: Clp_N; pfam02861 74547001471 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 74547001472 Walker A motif; other site 74547001473 ATP binding site [chemical binding]; other site 74547001474 Walker B motif; other site 74547001475 arginine finger; other site 74547001476 Protein-interacting V-domain of mammalian Alix and related domains; Region: V_Alix_like; cl14654 74547001477 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 74547001478 Walker A motif; other site 74547001479 ATP binding site [chemical binding]; other site 74547001480 Walker B motif; other site 74547001481 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 74547001482 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 74547001483 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 74547001484 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 74547001485 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 74547001486 metal binding site [ion binding]; metal-binding site 74547001487 Zinc-dependent metalloprotease; MMP_like sub-family 1. A group of bacterial, archaeal, and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_1; cd04279 74547001488 active site 74547001489 Predicted membrane protein (DUF2214); Region: DUF2214; pfam09980 74547001490 4 probable transmembrane helices predicted by TMHMM2.0 74547001491 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 74547001492 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 74547001493 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 74547001494 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 74547001495 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 74547001496 DNA binding residues [nucleotide binding] 74547001497 Uncharacterized conserved protein [Function unknown]; Region: COG3339 74547001498 Phosphate-starvation-inducible E; Region: PsiE; pfam06146 74547001499 2 probable transmembrane helices predicted by TMHMM2.0 74547001500 Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862 74547001501 nif11 domain/cupin domain protein; Region: nif11_cupin; TIGR03890 74547001502 Cytochrome c; Region: Cytochrom_C; cl11414 74547001503 YciI-like protein; Reviewed; Region: PRK12864 74547001504 AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250 74547001505 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 74547001506 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 74547001507 substrate binding site [chemical binding]; other site 74547001508 active site 74547001509 catalytic residues [active] 74547001510 heterodimer interface [polypeptide binding]; other site 74547001511 Protein of unknown function (DUF3007); Region: DUF3007; pfam11460 74547001512 2 probable transmembrane helices predicted by TMHMM2.0 74547001513 NADH dehydrogenase transmembrane subunit; Region: NdhL; pfam10716 74547001514 2 probable transmembrane helices predicted by TMHMM2.0 74547001515 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 74547001516 active site 74547001517 substrate binding pocket [chemical binding]; other site 74547001518 dimer interface [polypeptide binding]; other site 74547001519 K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367 74547001520 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 74547001521 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 74547001522 7 probable transmembrane helices predicted by TMHMM2.0 74547001523 glutathione reductase; Validated; Region: PRK06116 74547001524 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 74547001525 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 74547001526 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 74547001527 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 74547001528 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 74547001529 C-terminal domain interface [polypeptide binding]; other site 74547001530 GSH binding site (G-site) [chemical binding]; other site 74547001531 dimer interface [polypeptide binding]; other site 74547001532 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 74547001533 substrate binding pocket (H-site) [chemical binding]; other site 74547001534 N-terminal domain interface [polypeptide binding]; other site 74547001535 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 74547001536 6 probable transmembrane helices predicted by TMHMM2.0 74547001537 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 74547001538 pyridoxal 5'-phosphate binding site [chemical binding]; other site 74547001539 catalytic residue [active] 74547001540 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 74547001541 Coenzyme A binding pocket [chemical binding]; other site 74547001542 2 probable transmembrane helices predicted by TMHMM2.0 74547001543 2 probable transmembrane helices predicted by TMHMM2.0 74547001544 Protein of unknown function (DUF3119); Region: DUF3119; pfam11317 74547001545 1 probable transmembrane helix predicted for by TMHMM2.0 74547001546 Protein of unknown function, DUF393; Region: DUF393; pfam04134 74547001547 short chain dehydrogenase; Provisional; Region: PRK06197 74547001548 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 74547001549 putative NAD(P) binding site [chemical binding]; other site 74547001550 active site 74547001551 TPR repeat; Region: TPR_11; pfam13414 74547001552 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 74547001553 binding surface 74547001554 TPR motif; other site 74547001555 TPR repeat; Region: TPR_11; pfam13414 74547001556 TPR repeat; Region: TPR_11; pfam13414 74547001557 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 74547001558 binding surface 74547001559 TPR motif; other site 74547001560 TPR repeat; Region: TPR_11; pfam13414 74547001561 TPR repeat; Region: TPR_11; pfam13414 74547001562 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 74547001563 binding surface 74547001564 TPR motif; other site 74547001565 TPR repeat; Region: TPR_11; pfam13414 74547001566 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 74547001567 TPR repeat; Region: TPR_11; pfam13414 74547001568 binding surface 74547001569 TPR motif; other site 74547001570 2 probable transmembrane helices predicted by TMHMM2.0 74547001571 1 probable transmembrane helix predicted for by TMHMM2.0 74547001572 translocation protein TolB; Provisional; Region: tolB; PRK01029 74547001573 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 74547001574 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 74547001575 2 probable transmembrane helices predicted by TMHMM2.0 74547001576 AhpC/TSA antioxidant enzyme; Region: AhpC-TSA_2; pfam13911 74547001577 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 74547001578 Ferritin-like domain; Region: Ferritin; pfam00210 74547001579 ferroxidase diiron center [ion binding]; other site 74547001580 chlorophyll a/b binding light-harvesting protein; Region: PS_antenn_a_b; TIGR03041 74547001581 6 probable transmembrane helices predicted by TMHMM2.0 74547001582 helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419 74547001583 non-specific DNA interactions [nucleotide binding]; other site 74547001584 DNA binding site [nucleotide binding] 74547001585 sequence specific DNA binding site [nucleotide binding]; other site 74547001586 putative cAMP binding site [chemical binding]; other site 74547001587 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 74547001588 Ferritin-like domain; Region: Ferritin; pfam00210 74547001589 ferroxidase diiron center [ion binding]; other site 74547001590 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 74547001591 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 74547001592 Walker A/P-loop; other site 74547001593 ATP binding site [chemical binding]; other site 74547001594 Q-loop/lid; other site 74547001595 ABC transporter signature motif; other site 74547001596 Walker B; other site 74547001597 D-loop; other site 74547001598 H-loop/switch region; other site 74547001599 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 74547001600 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 74547001601 putative switch regulator; other site 74547001602 non-specific DNA interactions [nucleotide binding]; other site 74547001603 DNA binding site [nucleotide binding] 74547001604 sequence specific DNA binding site [nucleotide binding]; other site 74547001605 putative cAMP binding site [chemical binding]; other site 74547001606 Macrophage migration inhibitory factor (MIF); Region: MIF; pfam01187 74547001607 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 74547001608 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 74547001609 minor groove reading motif; other site 74547001610 helix-hairpin-helix signature motif; other site 74547001611 substrate binding pocket [chemical binding]; other site 74547001612 active site 74547001613 Rhomboid family; Region: Rhomboid; cl11446 74547001614 6 probable transmembrane helices predicted by TMHMM2.0 74547001615 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 74547001616 NADH(P)-binding; Region: NAD_binding_10; pfam13460 74547001617 NAD(P) binding site [chemical binding]; other site 74547001618 putative active site [active] 74547001619 PBP superfamily domain; Region: PBP_like_2; cl17296 74547001620 1 probable transmembrane helix predicted for by TMHMM2.0 74547001621 Cytochrome c; Region: Cytochrom_C; cl11414 74547001622 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 74547001623 1 probable transmembrane helix predicted for by TMHMM2.0 74547001624 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 74547001625 Coenzyme A binding pocket [chemical binding]; other site 74547001626 2 probable transmembrane helices predicted by TMHMM2.0 74547001627 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 74547001628 trimer interface [polypeptide binding]; other site 74547001629 putative Zn binding site [ion binding]; other site 74547001630 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 74547001631 GSH binding site [chemical binding]; other site 74547001632 catalytic residues [active] 74547001633 Protein of unknown function (DUF1662); Region: DUF1662; pfam07878 74547001634 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 74547001635 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 74547001636 Ion channel; Region: Ion_trans_2; pfam07885 74547001637 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 74547001638 membrane-bound complex binding site; other site 74547001639 hinge residues; other site 74547001640 3 probable transmembrane helices predicted by TMHMM2.0 74547001641 1 probable transmembrane helix predicted for by TMHMM2.0 74547001642 FOG: CBS domain [General function prediction only]; Region: COG0517 74547001643 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 74547001644 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 74547001645 3 probable transmembrane helices predicted by TMHMM2.0 74547001646 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 74547001647 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 74547001648 putative NAD(P) binding site [chemical binding]; other site 74547001649 active site 74547001650 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 74547001651 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 74547001652 catalytic residues [active] 74547001653 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 74547001654 metal binding site 2 [ion binding]; metal-binding site 74547001655 putative DNA binding helix; other site 74547001656 metal binding site 1 [ion binding]; metal-binding site 74547001657 dimer interface [polypeptide binding]; other site 74547001658 structural Zn2+ binding site [ion binding]; other site 74547001659 Protein of unknown function (DUF3685); Region: DUF3685; pfam12452 74547001660 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 74547001661 1 probable transmembrane helix predicted for by TMHMM2.0 74547001662 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996 74547001663 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 74547001664 Protein of unknown function (DUF1292); Region: DUF1292; cl01608 74547001665 Protein of unknown function (DUF3727); Region: DUF3727; pfam12527 74547001666 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 74547001667 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 74547001668 active site 74547001669 motif I; other site 74547001670 motif II; other site 74547001671 gamma-glutamyl kinase; Provisional; Region: PRK05429 74547001672 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 74547001673 nucleotide binding site [chemical binding]; other site 74547001674 homotetrameric interface [polypeptide binding]; other site 74547001675 putative phosphate binding site [ion binding]; other site 74547001676 putative allosteric binding site; other site 74547001677 PUA domain; Region: PUA; pfam01472 74547001678 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 74547001679 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 74547001680 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 74547001681 trimer interface [polypeptide binding]; other site 74547001682 active site 74547001683 UDP-GlcNAc binding site [chemical binding]; other site 74547001684 lipid binding site [chemical binding]; lipid-binding site 74547001685 tartrate dehydrogenase; Region: TTC; TIGR02089 74547001686 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 74547001687 Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029 74547001688 active site 74547001689 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 74547001690 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 74547001691 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 74547001692 5 probable transmembrane helices predicted by TMHMM2.0 74547001693 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 74547001694 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 74547001695 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 74547001696 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 74547001697 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 74547001698 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 74547001699 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 74547001700 intersubunit interface [polypeptide binding]; other site 74547001701 active site 74547001702 zinc binding site [ion binding]; other site 74547001703 Na+ binding site [ion binding]; other site 74547001704 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 74547001705 dimer interface [polypeptide binding]; other site 74547001706 catalytic triad [active] 74547001707 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 74547001708 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 74547001709 putative active site [active] 74547001710 catalytic triad [active] 74547001711 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 74547001712 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 74547001713 dimer interface [polypeptide binding]; other site 74547001714 PYR/PP interface [polypeptide binding]; other site 74547001715 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit [Energy production and conversion]; Region: PorA; COG0674 74547001716 TPP binding site [chemical binding]; other site 74547001717 substrate binding site [chemical binding]; other site 74547001718 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 74547001719 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 74547001720 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 74547001721 TPP-binding site [chemical binding]; other site 74547001722 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 74547001723 8 probable transmembrane helices predicted by TMHMM2.0 74547001724 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 74547001725 active site 74547001726 4 probable transmembrane helices predicted by TMHMM2.0 74547001727 4 probable transmembrane helices predicted by TMHMM2.0 74547001728 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2859 74547001729 1 probable transmembrane helix predicted for by TMHMM2.0 74547001730 3 probable transmembrane helices predicted by TMHMM2.0 74547001731 acetoin reductase; Validated; Region: PRK08643 74547001732 HetN oxidoreductase-like, classical (c) SDR; Region: HetN_like_SDR_c; cd08932 74547001733 putative NAD(P) binding site [chemical binding]; other site 74547001734 active site 74547001735 MAPEG family; Region: MAPEG; pfam01124 74547001736 4 probable transmembrane helices predicted by TMHMM2.0 74547001737 2 probable transmembrane helices predicted by TMHMM2.0 74547001738 Methyltransferase domain; Region: Methyltransf_23; pfam13489 74547001739 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 74547001740 S-adenosylmethionine binding site [chemical binding]; other site 74547001741 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 74547001742 S-adenosylmethionine binding site [chemical binding]; other site 74547001743 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 74547001744 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 74547001745 Walker A/P-loop; other site 74547001746 ATP binding site [chemical binding]; other site 74547001747 Q-loop/lid; other site 74547001748 ABC transporter signature motif; other site 74547001749 Walker B; other site 74547001750 D-loop; other site 74547001751 H-loop/switch region; other site 74547001752 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 74547001753 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 74547001754 dimer interface [polypeptide binding]; other site 74547001755 conserved gate region; other site 74547001756 putative PBP binding loops; other site 74547001757 ABC-ATPase subunit interface; other site 74547001758 5 probable transmembrane helices predicted by TMHMM2.0 74547001759 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 74547001760 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 74547001761 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 74547001762 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 74547001763 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 74547001764 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 74547001765 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 74547001766 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 74547001767 1 probable transmembrane helix predicted for by TMHMM2.0 74547001768 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 74547001769 1 probable transmembrane helix predicted for by TMHMM2.0 74547001770 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 74547001771 Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547 74547001772 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 74547001773 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 74547001774 putative active site [active] 74547001775 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 74547001776 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 74547001777 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 74547001778 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862 74547001779 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 74547001780 ligand binding site; other site 74547001781 oligomer interface; other site 74547001782 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 74547001783 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 74547001784 dimer interface [polypeptide binding]; other site 74547001785 N-terminal domain interface [polypeptide binding]; other site 74547001786 sulfate 1 binding site; other site 74547001787 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 74547001788 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 74547001789 tRNA; other site 74547001790 putative tRNA binding site [nucleotide binding]; other site 74547001791 putative NADP binding site [chemical binding]; other site 74547001792 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 74547001793 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 74547001794 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 74547001795 putative active site [active] 74547001796 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 74547001797 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 74547001798 substrate binding site [chemical binding]; other site 74547001799 hexamer interface [polypeptide binding]; other site 74547001800 metal binding site [ion binding]; metal-binding site 74547001801 cytochrome c biogenesis protein; Region: ccsA; CHL00045 74547001802 8 probable transmembrane helices predicted by TMHMM2.0 74547001803 Predicted permeases [General function prediction only]; Region: COG0795 74547001804 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 74547001805 6 probable transmembrane helices predicted by TMHMM2.0 74547001806 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 74547001807 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 74547001808 Walker A/P-loop; other site 74547001809 ATP binding site [chemical binding]; other site 74547001810 Q-loop/lid; other site 74547001811 ABC transporter signature motif; other site 74547001812 Walker B; other site 74547001813 D-loop; other site 74547001814 H-loop/switch region; other site 74547001815 OstA-like protein; Region: OstA; cl00844 74547001816 Domain of unknown function (DUF309); Region: DUF309; pfam03745 74547001817 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 74547001818 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 74547001819 G1 box; other site 74547001820 putative GEF interaction site [polypeptide binding]; other site 74547001821 GTP/Mg2+ binding site [chemical binding]; other site 74547001822 Switch I region; other site 74547001823 G2 box; other site 74547001824 G3 box; other site 74547001825 Switch II region; other site 74547001826 G4 box; other site 74547001827 G5 box; other site 74547001828 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 74547001829 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 74547001830 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 74547001831 geranylgeranyl reductase; Region: ChlP; TIGR02028 74547001832 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 74547001833 Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092 74547001834 sulfite reductase subunit beta; Provisional; Region: PRK13504 74547001835 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 74547001836 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 74547001837 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 74547001838 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 74547001839 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 74547001840 generic binding surface II; other site 74547001841 ssDNA binding site; other site 74547001842 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 74547001843 ATP binding site [chemical binding]; other site 74547001844 putative Mg++ binding site [ion binding]; other site 74547001845 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 74547001846 nucleotide binding region [chemical binding]; other site 74547001847 ATP-binding site [chemical binding]; other site 74547001848 elongation factor Ts; Reviewed; Region: tsf; PRK12332 74547001849 UBA/TS-N domain; Region: UBA; pfam00627 74547001850 Elongation factor TS; Region: EF_TS; pfam00889 74547001851 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 74547001852 rRNA interaction site [nucleotide binding]; other site 74547001853 S8 interaction site; other site 74547001854 putative laminin-1 binding site; other site 74547001855 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 74547001856 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 74547001857 Probable Catalytic site; other site 74547001858 metal-binding site 74547001859 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 74547001860 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 74547001861 Walker A/P-loop; other site 74547001862 ATP binding site [chemical binding]; other site 74547001863 Q-loop/lid; other site 74547001864 ABC transporter signature motif; other site 74547001865 Walker B; other site 74547001866 D-loop; other site 74547001867 H-loop/switch region; other site 74547001868 DevC protein; Region: devC; TIGR01185 74547001869 FtsX-like permease family; Region: FtsX; pfam02687 74547001870 4 probable transmembrane helices predicted by TMHMM2.0 74547001871 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 74547001872 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 74547001873 HlyD family secretion protein; Region: HlyD_3; pfam13437 74547001874 phycocyanobilin:ferredoxin oxidoreductase; Validated; Region: PRK02816 74547001875 1 probable transmembrane helix predicted for by TMHMM2.0 74547001876 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 74547001877 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 74547001878 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 74547001879 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 74547001880 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 74547001881 Protein of unknown function (DUF3148); Region: DUF3148; pfam11347 74547001882 BioY family; Region: BioY; pfam02632 74547001883 5 probable transmembrane helices predicted by TMHMM2.0 74547001884 lipoprotein signal peptidase; Provisional; Region: PRK14792 74547001885 4 probable transmembrane helices predicted by TMHMM2.0 74547001886 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 74547001887 GTP/Mg2+ binding site [chemical binding]; other site 74547001888 G5 box; other site 74547001889 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 74547001890 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 74547001891 G1 box; other site 74547001892 G1 box; other site 74547001893 GTP/Mg2+ binding site [chemical binding]; other site 74547001894 Switch I region; other site 74547001895 Switch I region; other site 74547001896 G2 box; other site 74547001897 G2 box; other site 74547001898 Switch II region; other site 74547001899 G3 box; other site 74547001900 G3 box; other site 74547001901 Switch II region; other site 74547001902 G4 box; other site 74547001903 G5 box; other site 74547001904 Domain of unknown function (DUF697); Region: DUF697; pfam05128 74547001905 3 probable transmembrane helices predicted by TMHMM2.0 74547001906 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 74547001907 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 74547001908 catalytic residue [active] 74547001909 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 74547001910 nucleoside/Zn binding site; other site 74547001911 dimer interface [polypeptide binding]; other site 74547001912 catalytic motif [active] 74547001913 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 74547001914 homodimer interface [polypeptide binding]; other site 74547001915 pyridoxal 5'-phosphate binding site [chemical binding]; other site 74547001916 catalytic residue [active] 74547001917 glutamine synthetase, type I; Region: GlnA; TIGR00653 74547001918 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 74547001919 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 74547001920 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 74547001921 8 probable transmembrane helices predicted by TMHMM2.0 74547001922 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 74547001923 7 probable transmembrane helices predicted by TMHMM2.0 74547001924 photosystem II reaction center protein Psb28; Provisional; Region: PRK13612 74547001925 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 74547001926 tRNA 2-selenouridine synthase; Region: tRNA_sel_U_synt; TIGR03167 74547001927 active site residue [active] 74547001928 GUN4-like; Region: GUN4; pfam05419 74547001929 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 74547001930 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 74547001931 Mg2+ binding site [ion binding]; other site 74547001932 G-X-G motif; other site 74547001933 Protein of unknown function (DUF3104); Region: DUF3104; pfam11302 74547001934 Methyltransferase domain; Region: Methyltransf_23; pfam13489 74547001935 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 74547001936 S-adenosylmethionine binding site [chemical binding]; other site 74547001937 nif11-like leader peptide domain; Region: ocin_TIGR03798 74547001938 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 74547001939 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 74547001940 Protein export membrane protein; Region: SecD_SecF; cl14618 74547001941 5 probable transmembrane helices predicted by TMHMM2.0 74547001942 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 74547001943 protein-export membrane protein SecD; Region: secD; TIGR01129 74547001944 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 74547001945 6 probable transmembrane helices predicted by TMHMM2.0 74547001946 pyruvate dehydrogenase E1 component beta subunit; Validated; Region: odpB; CHL00144 74547001947 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 74547001948 alpha subunit interface [polypeptide binding]; other site 74547001949 TPP binding site [chemical binding]; other site 74547001950 heterodimer interface [polypeptide binding]; other site 74547001951 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 74547001952 Protein of unknown function (DUF3082); Region: DUF3082; pfam11282 74547001953 2 probable transmembrane helices predicted by TMHMM2.0 74547001954 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK02534 74547001955 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 74547001956 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 74547001957 S-adenosylmethionine binding site [chemical binding]; other site 74547001958 glutamate dehydrogenase; Provisional; Region: PRK09414 74547001959 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 74547001960 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 74547001961 NAD(P) binding site [chemical binding]; other site 74547001962 hypothetical protein; Provisional; Region: PRK14689 74547001963 EamA-like transporter family; Region: EamA; pfam00892 74547001964 10 probable transmembrane helices predicted by TMHMM2.0 74547001965 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 74547001966 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 74547001967 1 probable transmembrane helix predicted for by TMHMM2.0 74547001968 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 74547001969 active site residue [active] 74547001970 DoxX; Region: DoxX; pfam07681 74547001971 3 probable transmembrane helices predicted by TMHMM2.0 74547001972 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 74547001973 2TM domain; Region: 2TM; pfam13239 74547001974 1 probable transmembrane helix predicted for by TMHMM2.0 74547001975 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 74547001976 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 74547001977 Catalytic site [active] 74547001978 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 74547001979 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 74547001980 active site 74547001981 DNA binding site [nucleotide binding] 74547001982 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 74547001983 DNA primase; Validated; Region: dnaG; PRK05667 74547001984 CHC2 zinc finger; Region: zf-CHC2; pfam01807 74547001985 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 74547001986 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 74547001987 active site 74547001988 metal binding site [ion binding]; metal-binding site 74547001989 interdomain interaction site; other site 74547001990 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 74547001991 Curli production assembly/transport component CsgG; Region: CsgG; pfam03783 74547001992 1 probable transmembrane helix predicted for by TMHMM2.0 74547001993 EamA-like transporter family; Region: EamA; pfam00892 74547001994 EamA-like transporter family; Region: EamA; pfam00892 74547001995 10 probable transmembrane helices predicted by TMHMM2.0 74547001996 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 74547001997 RuvA N terminal domain; Region: RuvA_N; pfam01330 74547001998 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 74547001999 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 74547002000 16S/18S rRNA binding site [nucleotide binding]; other site 74547002001 S13e-L30e interaction site [polypeptide binding]; other site 74547002002 25S rRNA binding site [nucleotide binding]; other site 74547002003 Protein of unknown function (DUF3464); Region: DUF3464; pfam11947 74547002004 2 probable transmembrane helices predicted by TMHMM2.0 74547002005 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK07374 74547002006 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 74547002007 active site 74547002008 PHP Thumb interface [polypeptide binding]; other site 74547002009 metal binding site [ion binding]; metal-binding site 74547002010 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 74547002011 generic binding surface I; other site 74547002012 generic binding surface II; other site 74547002013 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 74547002014 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 74547002015 Domain of unknown function (DUF1816); Region: DUF1816; pfam08846 74547002016 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 74547002017 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 74547002018 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 74547002019 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cl00258 74547002020 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 74547002021 anti sigma factor interaction site; other site 74547002022 regulatory phosphorylation site [posttranslational modification]; other site 74547002023 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 74547002024 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 74547002025 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 74547002026 catalytic site [active] 74547002027 subunit interface [polypeptide binding]; other site 74547002028 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 74547002029 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 74547002030 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 74547002031 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 74547002032 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 74547002033 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 74547002034 Walker A/P-loop; other site 74547002035 ATP binding site [chemical binding]; other site 74547002036 Q-loop/lid; other site 74547002037 ABC transporter signature motif; other site 74547002038 Walker B; other site 74547002039 D-loop; other site 74547002040 H-loop/switch region; other site 74547002041 6 probable transmembrane helices predicted by TMHMM2.0 74547002042 Thiol-disulfide isomerase and thioredoxins [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: TrxA; COG0526 74547002043 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119 74547002044 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 74547002045 Walker A/P-loop; other site 74547002046 ATP binding site [chemical binding]; other site 74547002047 Q-loop/lid; other site 74547002048 ABC transporter signature motif; other site 74547002049 Walker B; other site 74547002050 D-loop; other site 74547002051 H-loop/switch region; other site 74547002052 4 probable transmembrane helices predicted by TMHMM2.0 74547002053 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 74547002054 quinolinate synthetase; Provisional; Region: PRK09375 74547002055 TIGR04168 family protein; Region: TIGR04168 74547002056 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 74547002057 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 74547002058 catalytic residue [active] 74547002059 1 probable transmembrane helix predicted for by TMHMM2.0 74547002060 Repair protein; Region: Repair_PSII; pfam04536 74547002061 3 probable transmembrane helices predicted by TMHMM2.0 74547002062 Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636 74547002063 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 74547002064 active site 74547002065 dimer interface [polypeptide binding]; other site 74547002066 metal binding site [ion binding]; metal-binding site 74547002067 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 74547002068 dimer interface [polypeptide binding]; other site 74547002069 conserved gate region; other site 74547002070 putative PBP binding loops; other site 74547002071 ABC-ATPase subunit interface; other site 74547002072 5 probable transmembrane helices predicted by TMHMM2.0 74547002073 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 74547002074 ATP-grasp domain; Region: ATP-grasp; pfam02222 74547002075 Predicted metal-binding protein (DUF2103); Region: DUF2103; cl01651 74547002076 ATP-dependent Clp protease adaptor; Reviewed; Region: clpS; PRK13019 74547002077 cytochrome b6-f complex subunit PetN; Provisional; Region: petN; PRK02529 74547002078 1 probable transmembrane helix predicted for by TMHMM2.0 74547002079 Thf1-like protein; Reviewed; Region: PRK13266 74547002080 photosystem II biogenesis protein Psp29; Region: PS_II_psb29; TIGR03060 74547002081 Clp protease; Region: CLP_protease; pfam00574 74547002082 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 74547002083 oligomer interface [polypeptide binding]; other site 74547002084 active site residues [active] 74547002085 cell division protein; Validated; Region: ftsH; CHL00176 74547002086 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 74547002087 Walker A motif; other site 74547002088 ATP binding site [chemical binding]; other site 74547002089 Walker B motif; other site 74547002090 arginine finger; other site 74547002091 Peptidase family M41; Region: Peptidase_M41; pfam01434 74547002092 1 probable transmembrane helix predicted for by TMHMM2.0 74547002093 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 74547002094 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 74547002095 FtsX-like permease family; Region: FtsX; pfam02687 74547002096 4 probable transmembrane helices predicted by TMHMM2.0 74547002097 pyruvate kinase; Provisional; Region: PRK06354 74547002098 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 74547002099 domain interfaces; other site 74547002100 active site 74547002101 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 74547002102 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 74547002103 putative metal binding site [ion binding]; other site 74547002104 1 probable transmembrane helix predicted for by TMHMM2.0 74547002105 YGGT family; Region: YGGT; pfam02325 74547002106 2 probable transmembrane helices predicted by TMHMM2.0 74547002107 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 74547002108 threonine dehydratase; Reviewed; Region: PRK09224 74547002109 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 74547002110 tetramer interface [polypeptide binding]; other site 74547002111 pyridoxal 5'-phosphate binding site [chemical binding]; other site 74547002112 catalytic residue [active] 74547002113 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 74547002114 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 74547002115 putative Ile/Val binding site [chemical binding]; other site 74547002116 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 74547002117 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 74547002118 TPP-binding site; other site 74547002119 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 74547002120 PYR/PP interface [polypeptide binding]; other site 74547002121 dimer interface [polypeptide binding]; other site 74547002122 TPP binding site [chemical binding]; other site 74547002123 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 74547002124 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 74547002125 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 74547002126 photosystem I reaction center subunit PsaK; Region: PS_I_psaK; TIGR03049 74547002127 1 probable transmembrane helix predicted for by TMHMM2.0 74547002128 Protein of unknown function (DUF3593); Region: DUF3593; pfam12159 74547002129 3 probable transmembrane helices predicted by TMHMM2.0 74547002130 Protein of unknown function (DUF2499); Region: DUF2499; pfam10693 74547002131 3 probable transmembrane helices predicted by TMHMM2.0 74547002132 polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609 74547002133 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 74547002134 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 74547002135 Walker A/P-loop; other site 74547002136 ATP binding site [chemical binding]; other site 74547002137 Q-loop/lid; other site 74547002138 ABC transporter signature motif; other site 74547002139 Walker B; other site 74547002140 D-loop; other site 74547002141 H-loop/switch region; other site 74547002142 TOBE domain; Region: TOBE_2; pfam08402 74547002143 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 74547002144 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 74547002145 dimer interface [polypeptide binding]; other site 74547002146 conserved gate region; other site 74547002147 putative PBP binding loops; other site 74547002148 ABC-ATPase subunit interface; other site 74547002149 6 probable transmembrane helices predicted by TMHMM2.0 74547002150 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 74547002151 dimer interface [polypeptide binding]; other site 74547002152 conserved gate region; other site 74547002153 ABC-ATPase subunit interface; other site 74547002154 6 probable transmembrane helices predicted by TMHMM2.0 74547002155 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 74547002156 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 74547002157 1 probable transmembrane helix predicted for by TMHMM2.0 74547002158 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 74547002159 heat shock protein 90; Provisional; Region: PRK05218 74547002160 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 74547002161 ATP binding site [chemical binding]; other site 74547002162 Mg2+ binding site [ion binding]; other site 74547002163 G-X-G motif; other site 74547002164 Ferredoxin [Energy production and conversion]; Region: COG1146 74547002165 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 74547002166 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 74547002167 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 74547002168 dimer interface [polypeptide binding]; other site 74547002169 motif 1; other site 74547002170 active site 74547002171 motif 2; other site 74547002172 motif 3; other site 74547002173 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 74547002174 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 74547002175 active site 74547002176 dimerization interface [polypeptide binding]; other site 74547002177 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14259 74547002178 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 74547002179 Walker A/P-loop; other site 74547002180 ATP binding site [chemical binding]; other site 74547002181 Q-loop/lid; other site 74547002182 ABC transporter signature motif; other site 74547002183 Walker B; other site 74547002184 D-loop; other site 74547002185 H-loop/switch region; other site 74547002186 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 74547002187 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 74547002188 dimer interface [polypeptide binding]; other site 74547002189 conserved gate region; other site 74547002190 putative PBP binding loops; other site 74547002191 ABC-ATPase subunit interface; other site 74547002192 7 probable transmembrane helices predicted by TMHMM2.0 74547002193 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 74547002194 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 74547002195 dimer interface [polypeptide binding]; other site 74547002196 conserved gate region; other site 74547002197 ABC-ATPase subunit interface; other site 74547002198 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 74547002199 8 probable transmembrane helices predicted by TMHMM2.0 74547002200 molecular chaperone DnaK; Provisional; Region: PRK13410 74547002201 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 74547002202 nucleotide binding site [chemical binding]; other site 74547002203 DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214 74547002204 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 74547002205 HSP70 interaction site [polypeptide binding]; other site 74547002206 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 74547002207 substrate binding site [polypeptide binding]; other site 74547002208 dimer interface [polypeptide binding]; other site 74547002209 Protein of unknown function (DUF3110); Region: DUF3110; pfam11360 74547002210 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 74547002211 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 74547002212 putative active site [active] 74547002213 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 74547002214 active site 74547002215 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II/unknown domain fusion protein; Provisional; Region: PRK09319 74547002216 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 74547002217 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 74547002218 dimerization interface [polypeptide binding]; other site 74547002219 active site 74547002220 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 74547002221 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 74547002222 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 74547002223 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 74547002224 active site 74547002225 substrate binding site [chemical binding]; other site 74547002226 cosubstrate binding site; other site 74547002227 catalytic site [active] 74547002228 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 74547002229 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 74547002230 PDZ domain associated with archaeal and bacterial M61 glycyl-aminopeptidases. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) polypeptides and even to...; Region: PDZ_glycyl_aminopeptidase; cd00990 74547002231 protein binding site [polypeptide binding]; other site 74547002232 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 74547002233 amidase catalytic site [active] 74547002234 Zn binding residues [ion binding]; other site 74547002235 substrate binding site [chemical binding]; other site 74547002236 1 probable transmembrane helix predicted for by TMHMM2.0 74547002237 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14096 74547002238 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 74547002239 active site 74547002240 dimer interface [polypeptide binding]; other site 74547002241 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 74547002242 dimer interface [polypeptide binding]; other site 74547002243 active site 74547002244 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 74547002245 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 74547002246 HIGH motif; other site 74547002247 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 74547002248 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 74547002249 active site 74547002250 KMSKS motif; other site 74547002251 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 74547002252 tRNA binding surface [nucleotide binding]; other site 74547002253 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 74547002254 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 74547002255 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 74547002256 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 74547002257 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 74547002258 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 74547002259 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 74547002260 catalytic residue [active] 74547002261 Domain of unknown function (DUF1995); Region: DUF1995; pfam09353 74547002262 Domain of unknown function (DUF4330); Region: DUF4330; pfam14221 74547002263 1 probable transmembrane helix predicted for by TMHMM2.0 74547002264 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 74547002265 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 74547002266 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 74547002267 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 74547002268 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 74547002269 active site 74547002270 (T/H)XGH motif; other site 74547002271 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 74547002272 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 74547002273 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 74547002274 GIY-YIG motif/motif A; other site 74547002275 active site 74547002276 catalytic site [active] 74547002277 putative DNA binding site [nucleotide binding]; other site 74547002278 metal binding site [ion binding]; metal-binding site 74547002279 UvrB/uvrC motif; Region: UVR; pfam02151 74547002280 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 74547002281 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 74547002282 5 probable transmembrane helices predicted by TMHMM2.0 74547002283 PHP domain; Region: PHP; pfam02811 74547002284 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 74547002285 active site 74547002286 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 74547002287 CobN/Magnesium Chelatase; Region: CobN-Mg_chel; pfam02514 74547002288 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 74547002289 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 74547002290 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 74547002291 homodimer interface [polypeptide binding]; other site 74547002292 substrate-cofactor binding pocket; other site 74547002293 catalytic residue [active] 74547002294 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 74547002295 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 74547002296 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 74547002297 substrate binding pocket [chemical binding]; other site 74547002298 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 74547002299 B12 binding site [chemical binding]; other site 74547002300 cobalt ligand [ion binding]; other site 74547002301 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 74547002302 Stage II sporulation protein; Region: SpoIID; pfam08486 74547002303 1 probable transmembrane helix predicted for by TMHMM2.0 74547002304 ATP adenylyltransferase (5',5'''-P-1,P-4-tetraphosphate phosphorylase II) [Nucleotide transport and metabolism]; Region: APA2; COG4360 74547002305 ATP adenylyltransferase; Region: ATP_transf; pfam09830 74547002306 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 74547002307 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 74547002308 Protein of unknown function (DUF3370); Region: DUF3370; pfam11850 74547002309 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 74547002310 HSP70 interaction site [polypeptide binding]; other site 74547002311 TRAM domain; Region: TRAM; cl01282 74547002312 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 74547002313 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 74547002314 S-adenosylmethionine binding site [chemical binding]; other site 74547002315 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 74547002316 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 74547002317 putative tRNA-binding site [nucleotide binding]; other site 74547002318 B3/4 domain; Region: B3_4; pfam03483 74547002319 tRNA synthetase B5 domain; Region: B5; smart00874 74547002320 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 74547002321 dimer interface [polypeptide binding]; other site 74547002322 motif 1; other site 74547002323 motif 3; other site 74547002324 motif 2; other site 74547002325 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 74547002326 ribosomal protein L33; Region: rpl33; CHL00104 74547002327 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 74547002328 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 74547002329 RNB domain; Region: RNB; pfam00773 74547002330 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 74547002331 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 74547002332 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 74547002333 active site 74547002334 HIGH motif; other site 74547002335 KMSKS motif; other site 74547002336 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 74547002337 tRNA binding surface [nucleotide binding]; other site 74547002338 anticodon binding site; other site 74547002339 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 74547002340 Protein of unknown function (DUF2930); Region: DUF2930; pfam11152 74547002341 3 probable transmembrane helices predicted by TMHMM2.0 74547002342 tellurite resistance protein terB; Region: terB; cd07176 74547002343 putative metal binding site [ion binding]; other site 74547002344 Repair protein; Region: Repair_PSII; pfam04536 74547002345 2 probable transmembrane helices predicted by TMHMM2.0 74547002346 proton extrusion protein PcxA; Provisional; Region: PRK02507 74547002347 3 probable transmembrane helices predicted by TMHMM2.0 74547002348 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 74547002349 homotrimer interface [polypeptide binding]; other site 74547002350 Walker A motif; other site 74547002351 GTP binding site [chemical binding]; other site 74547002352 Walker B motif; other site 74547002353 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 74547002354 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 74547002355 Peptidase family M23; Region: Peptidase_M23; pfam01551 74547002356 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 74547002357 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 74547002358 Peptidase family M23; Region: Peptidase_M23; pfam01551 74547002359 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 74547002360 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 74547002361 dimer interface [polypeptide binding]; other site 74547002362 decamer (pentamer of dimers) interface [polypeptide binding]; other site 74547002363 catalytic triad [active] 74547002364 peroxidatic and resolving cysteines [active] 74547002365 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 74547002366 Uncharacterized conserved protein [Function unknown]; Region: COG1615 74547002367 9 probable transmembrane helices predicted by TMHMM2.0 74547002368 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 74547002369 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 74547002370 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 74547002371 Walker A motif; other site 74547002372 ATP binding site [chemical binding]; other site 74547002373 Walker B motif; other site 74547002374 arginine finger; other site 74547002375 Peptidase family M41; Region: Peptidase_M41; pfam01434 74547002376 1 probable transmembrane helix predicted for by TMHMM2.0 74547002377 ribosomal protein L32; Validated; Region: rpl32; CHL00152 74547002378 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 74547002379 active site 74547002380 2 probable transmembrane helices predicted by TMHMM2.0 74547002381 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 74547002382 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 74547002383 motif II; other site 74547002384 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 74547002385 DHH family; Region: DHH; pfam01368 74547002386 DHHA1 domain; Region: DHHA1; pfam02272 74547002387 ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034 74547002388 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 74547002389 putative ion selectivity filter; other site 74547002390 putative pore gating glutamate residue; other site 74547002391 putative H+/Cl- coupling transport residue; other site 74547002392 8 probable transmembrane helices predicted by TMHMM2.0 74547002393 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 74547002394 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 74547002395 Predicted membrane protein [Function unknown]; Region: COG2119 74547002396 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 74547002397 2 probable transmembrane helices predicted by TMHMM2.0 74547002398 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 74547002399 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 74547002400 RNB domain; Region: RNB; pfam00773 74547002401 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 74547002402 RNA binding site [nucleotide binding]; other site 74547002403 aromatic acid decarboxylase; Validated; Region: PRK05920 74547002404 Flavoprotein; Region: Flavoprotein; pfam02441 74547002405 2 probable transmembrane helices predicted by TMHMM2.0 74547002406 Protein of unknown function (DUF2996); Region: DUF2996; pfam11210 74547002407 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 74547002408 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 74547002409 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 74547002410 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 74547002411 putative active site [active] 74547002412 substrate binding site [chemical binding]; other site 74547002413 putative cosubstrate binding site; other site 74547002414 catalytic site [active] 74547002415 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 74547002416 substrate binding site [chemical binding]; other site 74547002417 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 74547002418 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 74547002419 [2Fe-2S] cluster binding site [ion binding]; other site 74547002420 1 probable transmembrane helix predicted for by TMHMM2.0 74547002421 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 74547002422 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 74547002423 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 74547002424 ATP binding site [chemical binding]; other site 74547002425 putative Mg++ binding site [ion binding]; other site 74547002426 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 74547002427 nucleotide binding region [chemical binding]; other site 74547002428 ATP-binding site [chemical binding]; other site 74547002429 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 74547002430 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 74547002431 C-terminal peptidase (prc); Region: prc; TIGR00225 74547002432 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 74547002433 protein binding site [polypeptide binding]; other site 74547002434 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 74547002435 Catalytic dyad [active] 74547002436 1 probable transmembrane helix predicted for by TMHMM2.0 74547002437 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 74547002438 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 74547002439 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 74547002440 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 74547002441 Fe-S cluster binding site [ion binding]; other site 74547002442 active site 74547002443 aspartate aminotransferase; Provisional; Region: PRK05764 74547002444 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 74547002445 pyridoxal 5'-phosphate binding site [chemical binding]; other site 74547002446 homodimer interface [polypeptide binding]; other site 74547002447 catalytic residue [active] 74547002448 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 74547002449 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 74547002450 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 74547002451 Walker A/P-loop; other site 74547002452 ATP binding site [chemical binding]; other site 74547002453 Q-loop/lid; other site 74547002454 ABC transporter signature motif; other site 74547002455 Walker B; other site 74547002456 D-loop; other site 74547002457 H-loop/switch region; other site 74547002458 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 74547002459 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 74547002460 12 probable transmembrane helices predicted by TMHMM2.0 74547002461 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_3; cd01835 74547002462 active site 74547002463 catalytic triad [active] 74547002464 oxyanion hole [active] 74547002465 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 74547002466 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 74547002467 Integral membrane protein DUF92; Region: DUF92; pfam01940 74547002468 6 probable transmembrane helices predicted by TMHMM2.0 74547002469 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 74547002470 Protein of unknown function (DUF3531); Region: DUF3531; pfam12049 74547002471 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 74547002472 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 74547002473 Walker A/P-loop; other site 74547002474 ATP binding site [chemical binding]; other site 74547002475 Q-loop/lid; other site 74547002476 ABC transporter signature motif; other site 74547002477 Walker B; other site 74547002478 D-loop; other site 74547002479 H-loop/switch region; other site 74547002480 Protein of unknown function (DUF3353); Region: DUF3353; pfam11833 74547002481 2 probable transmembrane helices predicted by TMHMM2.0 74547002482 Protein of unknown function (DUF1651); Region: DUF1651; pfam07864 74547002483 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 74547002484 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 74547002485 G1 box; other site 74547002486 putative GEF interaction site [polypeptide binding]; other site 74547002487 GTP/Mg2+ binding site [chemical binding]; other site 74547002488 Switch I region; other site 74547002489 G2 box; other site 74547002490 G3 box; other site 74547002491 Switch II region; other site 74547002492 G4 box; other site 74547002493 G5 box; other site 74547002494 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 74547002495 Methyltransferase domain; Region: Methyltransf_23; pfam13489 74547002496 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 74547002497 S-adenosylmethionine binding site [chemical binding]; other site 74547002498 ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent; Region: RTPR; TIGR02505 74547002499 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 74547002500 Protein of unknown function (DUF1662); Region: DUF1662; pfam07878 74547002501 GLTT repeat (6 copies); Region: GLTT; pfam01744 74547002502 2 probable transmembrane helices predicted by TMHMM2.0 74547002503 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 74547002504 Fatty acid desaturase; Region: FA_desaturase; pfam00487 74547002505 putative di-iron ligands [ion binding]; other site 74547002506 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 74547002507 4 probable transmembrane helices predicted by TMHMM2.0 74547002508 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 74547002509 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 74547002510 catalytic triad [active] 74547002511 flavodoxin FldA; Validated; Region: PRK09267 74547002512 S-layer homology domain; Region: SLH; pfam00395 74547002513 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 74547002514 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 74547002515 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 74547002516 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 74547002517 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 74547002518 ATP binding site [chemical binding]; other site 74547002519 Mg2+ binding site [ion binding]; other site 74547002520 G-X-G motif; other site 74547002521 2 probable transmembrane helices predicted by TMHMM2.0 74547002522 osmolarity response regulator; Provisional; Region: ompR; PRK09468 74547002523 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 74547002524 active site 74547002525 phosphorylation site [posttranslational modification] 74547002526 intermolecular recognition site; other site 74547002527 dimerization interface [polypeptide binding]; other site 74547002528 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 74547002529 DNA binding site [nucleotide binding] 74547002530 2 probable transmembrane helices predicted by TMHMM2.0 74547002531 Domain of unknown function (DUF4335); Region: DUF4335; pfam14233 74547002532 1 probable transmembrane helix predicted for by TMHMM2.0 74547002533 Protein of unknown function (DUF3038); Region: DUF3038; pfam11237 74547002534 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 74547002535 active site 74547002536 Protein of unknown function (DUF2949); Region: DUF2949; pfam11165 74547002537 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 74547002538 1 probable transmembrane helix predicted for by TMHMM2.0 74547002539 2 probable transmembrane helices predicted by TMHMM2.0 74547002540 dihydrodipicolinate reductase; Provisional; Region: PRK00048 74547002541 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 74547002542 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 74547002543 magnesium chelatase subunit H; Provisional; Region: PRK12493 74547002544 Domain of unknown function (DUF3479); Region: DUF3479; pfam11965 74547002545 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 74547002546 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 74547002547 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 74547002548 dihydropteroate synthase; Region: DHPS; TIGR01496 74547002549 substrate binding pocket [chemical binding]; other site 74547002550 dimer interface [polypeptide binding]; other site 74547002551 inhibitor binding site; inhibition site 74547002552 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 74547002553 triosephosphate isomerase; Provisional; Region: PRK14565 74547002554 substrate binding site [chemical binding]; other site 74547002555 dimer interface [polypeptide binding]; other site 74547002556 catalytic triad [active] 74547002557 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 74547002558 RNA binding surface [nucleotide binding]; other site 74547002559 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 74547002560 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 74547002561 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 74547002562 Walker A/P-loop; other site 74547002563 ATP binding site [chemical binding]; other site 74547002564 Q-loop/lid; other site 74547002565 ABC transporter signature motif; other site 74547002566 Walker B; other site 74547002567 D-loop; other site 74547002568 H-loop/switch region; other site 74547002569 4 probable transmembrane helices predicted by TMHMM2.0 74547002570 Protein of unknown function (DUF3386); Region: DUF3386; pfam11866 74547002571 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 74547002572 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 74547002573 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 74547002574 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 74547002575 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 74547002576 ATP-grasp domain; Region: ATP-grasp_4; cl17255 74547002577 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 74547002578 IMP binding site; other site 74547002579 dimer interface [polypeptide binding]; other site 74547002580 interdomain contacts; other site 74547002581 partial ornithine binding site; other site 74547002582 Protein of unknown function (DUF3318); Region: DUF3318; pfam11780 74547002583 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 74547002584 L-asparaginase II; Region: Asparaginase_II; pfam06089 74547002585 nif11-like leader peptide domain; Region: ocin_TIGR03798 74547002586 nif11-like leader peptide domain; Region: ocin_TIGR03798 74547002587 Transposase IS200 like; Region: Y1_Tnp; pfam01797 74547002588 Protein of unknown function (DUF1651); Region: DUF1651; pfam07864 74547002589 Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862 74547002590 Transposase IS200 like; Region: Y1_Tnp; cl00848 74547002591 Protein of unknown function (DUF1651); Region: DUF1651; pfam07864 74547002592 A bacterial subgroup of the C-type lectin-like (CTLD) domain; a subgroup of bacterial protein domains homologous to the carbohydrate-recognition domains (CRDs) of the C-type lectins; Region: CLECT_VCBS; cd03603 74547002593 ligand binding surface [chemical binding]; other site 74547002594 1 probable transmembrane helix predicted for by TMHMM2.0 74547002595 nif11-like leader peptide domain; Region: ocin_TIGR03798 74547002596 Carboxy-terminal domain of Formyltransferase and similar domains; Region: FMT_C_like; cl14785 74547002597 nif11-like leader peptide domain; Region: ocin_TIGR03798 74547002598 Protein of unknown function (DUF1651); Region: DUF1651; pfam07864 74547002599 Pyrimidine dimer DNA glycosylase; Region: Pyr_excise; pfam03013 74547002600 Putative ParB-like nuclease; Region: ParBc_2; cl17538 74547002601 4 probable transmembrane helices predicted by TMHMM2.0 74547002602 2 probable transmembrane helices predicted by TMHMM2.0 74547002603 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 74547002604 7 probable transmembrane helices predicted by TMHMM2.0 74547002605 Protein of unknown function (DUF1662); Region: DUF1662; pfam07878 74547002606 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 74547002607 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 74547002608 active site 74547002609 metal binding site [ion binding]; metal-binding site 74547002610 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026 74547002611 3 probable transmembrane helices predicted by TMHMM2.0 74547002612 Domain of unknown function (DUF389); Region: DUF389; pfam04087 74547002613 7 probable transmembrane helices predicted by TMHMM2.0 74547002614 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 74547002615 Mechanosensitive ion channel; Region: MS_channel; pfam00924 74547002616 6 probable transmembrane helices predicted by TMHMM2.0 74547002617 Isochorismatase family; Region: Isochorismatase; pfam00857 74547002618 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 74547002619 catalytic triad [active] 74547002620 dimer interface [polypeptide binding]; other site 74547002621 conserved cis-peptide bond; other site 74547002622 2 probable transmembrane helices predicted by TMHMM2.0 74547002623 1 probable transmembrane helix predicted for by TMHMM2.0 74547002624 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 74547002625 metal binding site 2 [ion binding]; metal-binding site 74547002626 putative DNA binding helix; other site 74547002627 metal binding site 1 [ion binding]; metal-binding site 74547002628 dimer interface [polypeptide binding]; other site 74547002629 structural Zn2+ binding site [ion binding]; other site 74547002630 Protein of unknown function; Region: DUF3721; pfam12518 74547002631 2 probable transmembrane helices predicted by TMHMM2.0 74547002632 Protein of unknown function; Region: DUF3721; pfam12518 74547002633 Protein of unknown function (DUF552); Region: DUF552; pfam04472 74547002634 radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167 74547002635 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 74547002636 FeS/SAM binding site; other site 74547002637 Protein of unknown function (DUF3641); Region: DUF3641; pfam12345 74547002638 glucosylglycerol 3-phosphatase; Region: salt_tol_Pase; TIGR02399 74547002639 Glucosylglycerol-phosphate phosphatase (Salt_tol_Pase); Region: Salt_tol_Pase; pfam09506 74547002640 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 74547002641 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 74547002642 Walker A/P-loop; other site 74547002643 ATP binding site [chemical binding]; other site 74547002644 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 74547002645 ABC transporter signature motif; other site 74547002646 Walker B; other site 74547002647 D-loop; other site 74547002648 H-loop/switch region; other site 74547002649 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 74547002650 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 74547002651 active site 74547002652 metal binding site [ion binding]; metal-binding site 74547002653 DNA binding site [nucleotide binding] 74547002654 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 74547002655 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 74547002656 DNA binding residues [nucleotide binding] 74547002657 dimerization interface [polypeptide binding]; other site 74547002658 Phosphotransferase enzyme family; Region: APH; pfam01636 74547002659 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 74547002660 substrate binding site [chemical binding]; other site 74547002661 Domon-like domain of UDP-N-acetylenolpyruvoylglucosamine reductase; Region: DOMON_murB_like; cd09627 74547002662 putative heme binding site [chemical binding]; other site 74547002663 1 probable transmembrane helix predicted for by TMHMM2.0 74547002664 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 74547002665 protochlorophyllide reductase; Region: PLN00015 74547002666 NAD(P) binding site [chemical binding]; other site 74547002667 active site 74547002668 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 74547002669 5 probable transmembrane helices predicted by TMHMM2.0 74547002670 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 74547002671 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 74547002672 N-acetyl-D-glucosamine binding site [chemical binding]; other site 74547002673 catalytic residue [active] 74547002674 2 probable transmembrane helices predicted by TMHMM2.0 74547002675 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 74547002676 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 74547002677 homodimer interface [polypeptide binding]; other site 74547002678 substrate-cofactor binding pocket; other site 74547002679 pyridoxal 5'-phosphate binding site [chemical binding]; other site 74547002680 catalytic residue [active] 74547002681 Homoserine O-succinyltransferase; Region: HTS; pfam04204 74547002682 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 74547002683 proposed active site lysine [active] 74547002684 conserved cys residue [active] 74547002685 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 74547002686 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 74547002687 AAA domain; Region: AAA_33; pfam13671 74547002688 active site 74547002689 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 74547002690 Staphylococcal nuclease homologues; Region: SNc; smart00318 74547002691 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 74547002692 Catalytic site; other site 74547002693 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 74547002694 1 probable transmembrane helix predicted for by TMHMM2.0 74547002695 nif11-like leader peptide domain; Region: ocin_TIGR03798 74547002696 Uncharacterized conserved protein [Function unknown]; Region: COG4095 74547002697 3 probable transmembrane helices predicted by TMHMM2.0 74547002698 1 probable transmembrane helix predicted for by TMHMM2.0 74547002699 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 74547002700 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 74547002701 Walker A/P-loop; other site 74547002702 ATP binding site [chemical binding]; other site 74547002703 Q-loop/lid; other site 74547002704 ABC transporter signature motif; other site 74547002705 Walker B; other site 74547002706 D-loop; other site 74547002707 H-loop/switch region; other site 74547002708 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 74547002709 dimer interface [polypeptide binding]; other site 74547002710 conserved gate region; other site 74547002711 putative PBP binding loops; other site 74547002712 ABC-ATPase subunit interface; other site 74547002713 7 probable transmembrane helices predicted by TMHMM2.0 74547002714 5 probable transmembrane helices predicted by TMHMM2.0 74547002715 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 74547002716 dimer interface [polypeptide binding]; other site 74547002717 conserved gate region; other site 74547002718 putative PBP binding loops; other site 74547002719 ABC-ATPase subunit interface; other site 74547002720 6 probable transmembrane helices predicted by TMHMM2.0 74547002721 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 74547002722 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 74547002723 substrate binding pocket [chemical binding]; other site 74547002724 membrane-bound complex binding site; other site 74547002725 hinge residues; other site 74547002726 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 74547002727 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 74547002728 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 74547002729 Sulfate transporter family; Region: Sulfate_transp; pfam00916 74547002730 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 74547002731 12 probable transmembrane helices predicted by TMHMM2.0 74547002732 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 74547002733 FAD binding domain; Region: FAD_binding_4; pfam01565 74547002734 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 74547002735 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 74547002736 putative active site [active] 74547002737 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 74547002738 putative active site [active] 74547002739 Protein of unknown function (DUF2811); Region: DUF2811; pfam10929 74547002740 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 74547002741 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 74547002742 3 probable transmembrane helices predicted by TMHMM2.0 74547002743 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 74547002744 SPFH domain / Band 7 family; Region: Band_7; pfam01145 74547002745 1 probable transmembrane helix predicted for by TMHMM2.0 74547002746 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 74547002747 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 74547002748 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 74547002749 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 74547002750 substrate binding pocket [chemical binding]; other site 74547002751 membrane-bound complex binding site; other site 74547002752 hinge residues; other site 74547002753 11 probable transmembrane helices predicted by TMHMM2.0 74547002754 Guanosine kinase-like sugar kinases. Found in bacteria and archaea, the guanosine kinase-like group is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: Guanosine_kinase_like; cd01947 74547002755 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 74547002756 substrate binding site [chemical binding]; other site 74547002757 ATP binding site [chemical binding]; other site 74547002758 Tryptophan-rich protein (DUF2389); Region: DUF2389; pfam09493 74547002759 1 probable transmembrane helix predicted for by TMHMM2.0 74547002760 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 74547002761 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 74547002762 ligand binding site [chemical binding]; other site 74547002763 1 probable transmembrane helix predicted for by TMHMM2.0 74547002764 Uncharacterized conserved protein [Function unknown]; Region: COG4095 74547002765 3 probable transmembrane helices predicted by TMHMM2.0 74547002766 10 probable transmembrane helices predicted by TMHMM2.0 74547002767 Domain of unknown function (DUF3854); Region: DUF3854; pfam12965 74547002768 Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862 74547002769 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 74547002770 nif11-like leader peptide domain; Region: ocin_TIGR03798 74547002771 nif11-like leader peptide domain; Region: ocin_TIGR03798 74547002772 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 74547002773 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 74547002774 5 probable transmembrane helices predicted by TMHMM2.0 74547002775 Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862 74547002776 Pleckstrin homology-like domain; Region: PH-like; cl17171 74547002777 Protein of unknown function (DUF3303); Region: DUF3303; pfam11746 74547002778 TPR repeat; Region: TPR_11; pfam13414 74547002779 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 74547002780 binding surface 74547002781 TPR motif; other site 74547002782 TPR repeat; Region: TPR_11; pfam13414 74547002783 TPR repeat; Region: TPR_11; pfam13414 74547002784 Tetratricopeptide repeat; Region: TPR_1; pfam00515 74547002785 TPR repeat; Region: TPR_11; pfam13414 74547002786 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 74547002787 binding surface 74547002788 TPR motif; other site 74547002789 TPR repeat; Region: TPR_11; pfam13414 74547002790 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 74547002791 binding surface 74547002792 TPR motif; other site 74547002793 Protein of unknown function (DUF3764); Region: DUF3764; pfam12594 74547002794 phage integrase family, possible pseudogene 74547002795 Cupin domain; Region: Cupin_2; cl17218 74547002796 2 probable transmembrane helices predicted by TMHMM2.0 74547002797 Protein of unknown function (DUF1330); Region: DUF1330; pfam07045 74547002798 Protein of unknown function (DUF3303); Region: DUF3303; pfam11746 74547002799 VanW like protein; Region: VanW; pfam04294 74547002800 Uncharacterized conserved protein [Function unknown]; Region: COG3349 74547002801 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 74547002802 Transposase IS200 like; Region: Y1_Tnp; pfam01797 74547002803 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 74547002804 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 74547002805 Transposase IS200 like; Region: Y1_Tnp; pfam01797 74547002806 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 74547002807 Protein of unknown function (DUF3303); Region: DUF3303; pfam11746 74547002808 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 74547002809 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 74547002810 metal binding site [ion binding]; metal-binding site 74547002811 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 74547002812 AAA domain; Region: AAA_14; pfam13173 74547002813 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 74547002814 1 probable transmembrane helix predicted for by TMHMM2.0 74547002815 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996 74547002816 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 74547002817 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 74547002818 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 74547002819 Walker A/P-loop; other site 74547002820 ATP binding site [chemical binding]; other site 74547002821 Q-loop/lid; other site 74547002822 ABC transporter signature motif; other site 74547002823 Walker B; other site 74547002824 D-loop; other site 74547002825 H-loop/switch region; other site 74547002826 6 probable transmembrane helices predicted by TMHMM2.0 74547002827 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39D; cd02420 74547002828 NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein; Region: NHLM_micro_ABC1; TIGR03796 74547002829 putative active site [active] 74547002830 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 74547002831 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 74547002832 Walker A/P-loop; other site 74547002833 ATP binding site [chemical binding]; other site 74547002834 Q-loop/lid; other site 74547002835 ABC transporter signature motif; other site 74547002836 Walker B; other site 74547002837 D-loop; other site 74547002838 H-loop/switch region; other site 74547002839 5 probable transmembrane helices predicted by TMHMM2.0 74547002840 NHLM bacteriocin system secretion protein; Region: NHLM_micro_HlyD; TIGR03794 74547002841 Protein of unknown function (DUF1640); Region: DUF1640; pfam07798 74547002842 Outer membrane efflux protein; Region: OEP; pfam02321 74547002843 Outer membrane efflux protein; Region: OEP; pfam02321 74547002844 2 probable transmembrane helices predicted by TMHMM2.0 74547002845 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 74547002846 2 probable transmembrane helices predicted by TMHMM2.0 74547002847 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 74547002848 1 probable transmembrane helix predicted for by TMHMM2.0 74547002849 putative high light inducible protein; Region: PHA02337 74547002850 2TM domain; Region: 2TM; pfam13239 74547002851 1 probable transmembrane helix predicted for by TMHMM2.0 74547002852 putative high light inducible protein; Region: PHA02337 74547002853 PBP superfamily domain; Region: PBP_like_2; cl17296 74547002854 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 74547002855 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 74547002856 active site 74547002857 phosphorylation site [posttranslational modification] 74547002858 intermolecular recognition site; other site 74547002859 dimerization interface [polypeptide binding]; other site 74547002860 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 74547002861 DNA binding site [nucleotide binding] 74547002862 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 74547002863 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 74547002864 ATP binding site [chemical binding]; other site 74547002865 Mg2+ binding site [ion binding]; other site 74547002866 G-X-G motif; other site 74547002867 S-layer homology domain; Region: SLH; pfam00395 74547002868 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 74547002869 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 74547002870 FAD binding pocket [chemical binding]; other site 74547002871 conserved FAD binding motif [chemical binding]; other site 74547002872 phosphate binding motif [ion binding]; other site 74547002873 beta-alpha-beta structure motif; other site 74547002874 NAD binding pocket [chemical binding]; other site 74547002875 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 74547002876 11 probable transmembrane helices predicted by TMHMM2.0 74547002877 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK08955 74547002878 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 74547002879 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 74547002880 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 74547002881 putative DNA binding site [nucleotide binding]; other site 74547002882 dimerization interface [polypeptide binding]; other site 74547002883 putative Zn2+ binding site [ion binding]; other site 74547002884 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 74547002885 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 74547002886 2 probable transmembrane helices predicted by TMHMM2.0 74547002887 Protein of unknown function (DUF1651); Region: DUF1651; pfam07864 74547002888 Bacterial trigger factor protein (TF); Region: Trigger_N; pfam05697 74547002889 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 74547002890 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 74547002891 catalytic triad [active] 74547002892 Phytochelatin synthase; Region: Phytochelatin; pfam05023 74547002893 1 probable transmembrane helix predicted for by TMHMM2.0 74547002894 Domain of Unknown Function (DUF1543); Region: DUF1543; pfam07566 74547002895 Domain of Unknown Function (DUF1543); Region: DUF1543; pfam07566 74547002896 3 probable transmembrane helices predicted by TMHMM2.0 74547002897 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 74547002898 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 74547002899 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 74547002900 6 probable transmembrane helices predicted by TMHMM2.0 74547002901 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 74547002902 Ion channel; Region: Ion_trans_2; pfam07885 74547002903 3 probable transmembrane helices predicted by TMHMM2.0 74547002904 MAPEG family; Region: MAPEG; pfam01124 74547002905 3 probable transmembrane helices predicted by TMHMM2.0 74547002906 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_23; cd04682 74547002907 nudix motif; other site 74547002908 1 probable transmembrane helix predicted for by TMHMM2.0 74547002909 Protein of unknown function (DUF861); Region: Cupin_3; pfam05899 74547002910 aspartate aminotransferase; Provisional; Region: PRK05957 74547002911 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 74547002912 pyridoxal 5'-phosphate binding site [chemical binding]; other site 74547002913 homodimer interface [polypeptide binding]; other site 74547002914 catalytic residue [active] 74547002915 Dienelactone hydrolase family; Region: DLH; pfam01738 74547002916 Domain of unknown function (DUF427); Region: DUF427; pfam04248 74547002917 1 probable transmembrane helix predicted for by TMHMM2.0 74547002918 Protein of unknown function (DUF1499); Region: DUF1499; pfam07386 74547002919 1 probable transmembrane helix predicted for by TMHMM2.0 74547002920 Protein of unknown function (DUF3288); Region: DUF3288; pfam11691 74547002921 OsmC-like protein; Region: OsmC; pfam02566 74547002922 2 probable transmembrane helices predicted by TMHMM2.0 74547002923 1 probable transmembrane helix predicted for by TMHMM2.0 74547002924 1 probable transmembrane helix predicted for by TMHMM2.0 74547002925 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 74547002926 metabolite-proton symporter; Region: 2A0106; TIGR00883 74547002927 putative substrate translocation pore; other site 74547002928 12 probable transmembrane helices predicted by TMHMM2.0 74547002929 1 probable transmembrane helix predicted for by TMHMM2.0 74547002930 chlorophyll a/b binding light-harvesting protein; Region: PS_antenn_a_b; TIGR03041 74547002931 6 probable transmembrane helices predicted by TMHMM2.0 74547002932 Photosystem II protein Y (PsbY); Region: PsbY; cl05675 74547002933 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 74547002934 Glucose inhibited division protein A; Region: GIDA; pfam01134 74547002935 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 74547002936 carotene isomerase; Region: carot_isom; TIGR02730 74547002937 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 74547002938 hydroxyglutarate oxidase; Provisional; Region: PRK11728 74547002939 aminopeptidase N; Provisional; Region: pepN; PRK14015 74547002940 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 74547002941 active site 74547002942 Zn binding site [ion binding]; other site 74547002943 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 74547002944 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 74547002945 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 74547002946 active site residue [active] 74547002947 biotin synthase; Region: bioB; TIGR00433 74547002948 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 74547002949 FeS/SAM binding site; other site 74547002950 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 74547002951 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 74547002952 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 74547002953 catalytic residue [active] 74547002954 putative FPP diphosphate binding site; other site 74547002955 putative FPP binding hydrophobic cleft; other site 74547002956 dimer interface [polypeptide binding]; other site 74547002957 putative IPP diphosphate binding site; other site 74547002958 Uncharacterized conserved protein [Function unknown]; Region: COG1624 74547002959 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 74547002960 2 probable transmembrane helices predicted by TMHMM2.0 74547002961 diaminopimelate decarboxylase; Region: lysA; TIGR01048 74547002962 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 74547002963 active site 74547002964 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 74547002965 substrate binding site [chemical binding]; other site 74547002966 catalytic residues [active] 74547002967 dimer interface [polypeptide binding]; other site 74547002968 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 74547002969 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 74547002970 Coenzyme A binding pocket [chemical binding]; other site 74547002971 Clp protease ATP binding subunit; Region: clpC; CHL00095 74547002972 Clp amino terminal domain; Region: Clp_N; pfam02861 74547002973 Clp amino terminal domain; Region: Clp_N; pfam02861 74547002974 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 74547002975 Walker A motif; other site 74547002976 ATP binding site [chemical binding]; other site 74547002977 Walker B motif; other site 74547002978 arginine finger; other site 74547002979 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 74547002980 Walker A motif; other site 74547002981 ATP binding site [chemical binding]; other site 74547002982 Walker B motif; other site 74547002983 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 74547002984 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 74547002985 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 74547002986 putative active site [active] 74547002987 metal binding site [ion binding]; metal-binding site 74547002988 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 74547002989 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 74547002990 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 74547002991 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 74547002992 phosphatidate cytidylyltransferase; Region: PLN02953 74547002993 6 probable transmembrane helices predicted by TMHMM2.0 74547002994 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 74547002995 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 74547002996 catalytic residue [active] 74547002997 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 74547002998 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 74547002999 ABC1 family; Region: ABC1; cl17513 74547003000 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 74547003001 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 74547003002 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 74547003003 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 74547003004 Sigma-70, region 4; Region: Sigma70_r4; pfam04545 74547003005 DNA binding residues [nucleotide binding] 74547003006 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 74547003007 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 74547003008 RNA binding surface [nucleotide binding]; other site 74547003009 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 74547003010 active site 74547003011 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 74547003012 non-specific DNA binding site [nucleotide binding]; other site 74547003013 salt bridge; other site 74547003014 sequence-specific DNA binding site [nucleotide binding]; other site 74547003015 4-alpha-glucanotransferase; Provisional; Region: PRK14508 74547003016 Transcriptional regulator [Transcription]; Region: LytR; COG1316 74547003017 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02812 74547003018 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 74547003019 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 74547003020 active site 74547003021 lipoyl synthase; Provisional; Region: PRK12928 74547003022 recombination protein RecR; Reviewed; Region: recR; PRK00076 74547003023 RecR protein; Region: RecR; pfam02132 74547003024 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 74547003025 putative active site [active] 74547003026 putative metal-binding site [ion binding]; other site 74547003027 tetramer interface [polypeptide binding]; other site 74547003028 PsbP; Region: PsbP; pfam01789 74547003029 Transcriptional regulator [Transcription]; Region: LytR; COG1316 74547003030 1 probable transmembrane helix predicted for by TMHMM2.0 74547003031 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 74547003032 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 74547003033 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 74547003034 Walker A/P-loop; other site 74547003035 ATP binding site [chemical binding]; other site 74547003036 Q-loop/lid; other site 74547003037 ABC transporter signature motif; other site 74547003038 Walker B; other site 74547003039 D-loop; other site 74547003040 H-loop/switch region; other site 74547003041 3 probable transmembrane helices predicted by TMHMM2.0 74547003042 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 74547003043 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 74547003044 helicase 45; Provisional; Region: PTZ00424 74547003045 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 74547003046 ATP binding site [chemical binding]; other site 74547003047 Mg++ binding site [ion binding]; other site 74547003048 motif III; other site 74547003049 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 74547003050 nucleotide binding region [chemical binding]; other site 74547003051 ATP-binding site [chemical binding]; other site 74547003052 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 74547003053 putative RNA binding site [nucleotide binding]; other site 74547003054 Cupin domain; Region: Cupin_2; cl17218 74547003055 AAA domain; Region: AAA_30; pfam13604 74547003056 AAA domain; Region: AAA_22; pfam13401 74547003057 Family description; Region: UvrD_C_2; pfam13538 74547003058 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 74547003059 Part of AAA domain; Region: AAA_19; pfam13245 74547003060 Family description; Region: UvrD_C_2; pfam13538 74547003061 11 probable transmembrane helices predicted by TMHMM2.0 74547003062 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 74547003063 2 probable transmembrane helices predicted by TMHMM2.0 74547003064 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 74547003065 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 74547003066 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 74547003067 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 74547003068 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 74547003069 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 74547003070 active site 74547003071 metal binding site [ion binding]; metal-binding site 74547003072 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 74547003073 active site 74547003074 hydrophilic channel; other site 74547003075 dimerization interface [polypeptide binding]; other site 74547003076 catalytic residues [active] 74547003077 active site lid [active] 74547003078 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 74547003079 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 74547003080 putative acyl-acceptor binding pocket; other site 74547003081 BolA-like protein; Region: BolA; pfam01722 74547003082 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 74547003083 putative GSH binding site [chemical binding]; other site 74547003084 catalytic residues [active] 74547003085 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 74547003086 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 74547003087 active site 74547003088 phosphorylation site [posttranslational modification] 74547003089 dimerization interface [polypeptide binding]; other site 74547003090 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 74547003091 DNA binding site [nucleotide binding] 74547003092 adaptive-response sensory kinase; Validated; Region: PRK09303 74547003093 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 74547003094 tetramer interface [polypeptide binding]; other site 74547003095 dimer interface [polypeptide binding]; other site 74547003096 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 74547003097 dimer interface [polypeptide binding]; other site 74547003098 phosphorylation site [posttranslational modification] 74547003099 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 74547003100 ATP binding site [chemical binding]; other site 74547003101 Mg2+ binding site [ion binding]; other site 74547003102 G-X-G motif; other site 74547003103 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_11; cd08866 74547003104 putative hydrophobic ligand binding site [chemical binding]; other site 74547003105 ferredoxin--NADP+ reductase; Provisional; Region: PLN03116 74547003106 These ferredoxin reductases are related to the NADPH cytochrome p450 reductases (CYPOR), but lack the FAD-binding region connecting sub-domain. Ferredoxin-NADP+ reductase (FNR) is an FAD-containing enzyme that catalyzes the reversible electron transfer...; Region: CYPOR_like_FNR; cd06208 74547003107 dimerization interface [polypeptide binding]; other site 74547003108 FAD binding pocket [chemical binding]; other site 74547003109 FAD binding motif [chemical binding]; other site 74547003110 catalytic residues [active] 74547003111 NAD binding pocket [chemical binding]; other site 74547003112 phosphate binding motif [ion binding]; other site 74547003113 beta-alpha-beta structure motif; other site 74547003114 1 probable transmembrane helix predicted for by TMHMM2.0 74547003115 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 74547003116 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 74547003117 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 74547003118 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 74547003119 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 74547003120 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 74547003121 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 74547003122 catalytic triad [active] 74547003123 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 74547003124 catalytic core [active] 74547003125 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 74547003126 4 probable transmembrane helices predicted by TMHMM2.0 74547003127 AAA domain; Region: AAA_30; pfam13604 74547003128 Family description; Region: UvrD_C_2; pfam13538 74547003129 Divergent PAP2 family; Region: DUF212; pfam02681 74547003130 2 probable transmembrane helices predicted by TMHMM2.0 74547003131 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 74547003132 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 74547003133 substrate binding pocket [chemical binding]; other site 74547003134 chain length determination region; other site 74547003135 substrate-Mg2+ binding site; other site 74547003136 catalytic residues [active] 74547003137 aspartate-rich region 1; other site 74547003138 active site lid residues [active] 74547003139 aspartate-rich region 2; other site 74547003140 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14186 74547003141 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 74547003142 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 74547003143 homodimer interface [polypeptide binding]; other site 74547003144 NADP binding site [chemical binding]; other site 74547003145 substrate binding site [chemical binding]; other site 74547003146 7TM-HD extracellular; Region: 7TMR-HDED; pfam07697 74547003147 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 74547003148 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 74547003149 Zn2+ binding site [ion binding]; other site 74547003150 Mg2+ binding site [ion binding]; other site 74547003151 5 probable transmembrane helices predicted by TMHMM2.0 74547003152 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 74547003153 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 74547003154 active site 74547003155 4 probable transmembrane helices predicted by TMHMM2.0 74547003156 1 probable transmembrane helix predicted for by TMHMM2.0 74547003157 Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862 74547003158 cysteinyl-tRNA synthetase; Region: cysS; TIGR00435 74547003159 1 probable transmembrane helix predicted for by TMHMM2.0 74547003160 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 74547003161 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 74547003162 dimer interface [polypeptide binding]; other site 74547003163 conserved gate region; other site 74547003164 putative PBP binding loops; other site 74547003165 ABC-ATPase subunit interface; other site 74547003166 6 probable transmembrane helices predicted by TMHMM2.0 74547003167 2-isopropylmalate synthase; Validated; Region: PRK00915 74547003168 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 74547003169 active site 74547003170 catalytic residues [active] 74547003171 metal binding site [ion binding]; metal-binding site 74547003172 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 74547003173 Uncharacterized conserved protein [Function unknown]; Region: COG1543 74547003174 N-terminal catalytic domain of alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792 74547003175 active site 74547003176 substrate binding site [chemical binding]; other site 74547003177 catalytic site [active] 74547003178 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 74547003179 lycopene cyclase family protein; Region: carotene-cycl; TIGR01790 74547003180 lycopene cyclase; Region: lycopene_cycl; TIGR01789 74547003181 DNA gyrase subunit A; Validated; Region: PRK05560 74547003182 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 74547003183 CAP-like domain; other site 74547003184 active site 74547003185 primary dimer interface [polypeptide binding]; other site 74547003186 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 74547003187 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 74547003188 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 74547003189 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 74547003190 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 74547003191 Domain of unknown function (DUF4308); Region: DUF4308; pfam14159 74547003192 2 probable transmembrane helices predicted by TMHMM2.0 74547003193 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 74547003194 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 74547003195 active site 74547003196 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 74547003197 catalytic residues [active] 74547003198 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 74547003199 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 74547003200 putative active site [active] 74547003201 oxyanion strand; other site 74547003202 catalytic triad [active] 74547003203 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 74547003204 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 74547003205 S-adenosylmethionine binding site [chemical binding]; other site 74547003206 cytochrome b6-f complex subunit PetG; Reviewed; Region: petG; PRK00665 74547003207 1 probable transmembrane helix predicted for by TMHMM2.0 74547003208 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 74547003209 Cytochrome c; Region: Cytochrom_C; pfam00034 74547003210 1 probable transmembrane helix predicted for by TMHMM2.0 74547003211 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 74547003212 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 74547003213 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 74547003214 1 probable transmembrane helix predicted for by TMHMM2.0 74547003215 Protein of unknown function (DUF3370); Region: DUF3370; pfam11850 74547003216 Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081 74547003217 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 74547003218 Walker A motif; other site 74547003219 ATP binding site [chemical binding]; other site 74547003220 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 74547003221 active site 74547003222 putative DNA-binding cleft [nucleotide binding]; other site 74547003223 dimer interface [polypeptide binding]; other site 74547003224 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 74547003225 S-adenosylmethionine binding site [chemical binding]; other site 74547003226 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 74547003227 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 74547003228 Fe-S metabolism associated domain; Region: SufE; cl00951 74547003229 homoserine dehydrogenase; Provisional; Region: PRK06349 74547003230 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 74547003231 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 74547003232 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 74547003233 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_20; cd08519 74547003234 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 74547003235 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 74547003236 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 74547003237 dimer interface [polypeptide binding]; other site 74547003238 conserved gate region; other site 74547003239 putative PBP binding loops; other site 74547003240 ABC-ATPase subunit interface; other site 74547003241 6 probable transmembrane helices predicted by TMHMM2.0 74547003242 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 74547003243 1 probable transmembrane helix predicted for by TMHMM2.0 74547003244 possible porin-likely pseudogene 74547003245 putative high light inducible protein; Region: PHA02337 74547003246 putative high light inducible protein; Region: PHA02337 74547003247 putative high light inducible protein; Region: PHA02337 74547003248 GTP-binding protein YchF; Reviewed; Region: PRK09601 74547003249 YchF GTPase; Region: YchF; cd01900 74547003250 G1 box; other site 74547003251 GTP/Mg2+ binding site [chemical binding]; other site 74547003252 Switch I region; other site 74547003253 G2 box; other site 74547003254 Switch II region; other site 74547003255 G3 box; other site 74547003256 G4 box; other site 74547003257 G5 box; other site 74547003258 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 74547003259 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 74547003260 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 74547003261 HlyD family secretion protein; Region: HlyD_3; pfam13437 74547003262 1 probable transmembrane helix predicted for by TMHMM2.0 74547003263 DNA polymerase I; Provisional; Region: PRK05755 74547003264 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 74547003265 active site 74547003266 metal binding site 1 [ion binding]; metal-binding site 74547003267 putative 5' ssDNA interaction site; other site 74547003268 metal binding site 3; metal-binding site 74547003269 metal binding site 2 [ion binding]; metal-binding site 74547003270 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 74547003271 putative DNA binding site [nucleotide binding]; other site 74547003272 putative metal binding site [ion binding]; other site 74547003273 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 74547003274 active site 74547003275 catalytic site [active] 74547003276 substrate binding site [chemical binding]; other site 74547003277 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 74547003278 active site 74547003279 DNA binding site [nucleotide binding] 74547003280 catalytic site [active] 74547003281 Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093 74547003282 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 74547003283 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 74547003284 active site 74547003285 HIGH motif; other site 74547003286 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 74547003287 KMSKS motif; other site 74547003288 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 74547003289 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 74547003290 putative substrate binding site 1 [chemical binding]; other site 74547003291 Na binding site 1 [ion binding]; other site 74547003292 putative substrate binding site 2 [chemical binding]; other site 74547003293 Na2 binding site [ion binding]; other site 74547003294 11 probable transmembrane helices predicted by TMHMM2.0 74547003295 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 74547003296 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 74547003297 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 74547003298 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 74547003299 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 74547003300 dimer interface [polypeptide binding]; other site 74547003301 [2Fe-2S] cluster binding site [ion binding]; other site 74547003302 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 74547003303 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 74547003304 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 74547003305 8 probable transmembrane helices predicted by TMHMM2.0 74547003306 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 74547003307 2 probable transmembrane helices predicted by TMHMM2.0 74547003308 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 74547003309 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 74547003310 ligand binding site [chemical binding]; other site 74547003311 homodimer interface [polypeptide binding]; other site 74547003312 NAD(P) binding site [chemical binding]; other site 74547003313 trimer interface B [polypeptide binding]; other site 74547003314 trimer interface A [polypeptide binding]; other site 74547003315 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 74547003316 ATP binding site [chemical binding]; other site 74547003317 putative Mg++ binding site [ion binding]; other site 74547003318 nucleotide binding region [chemical binding]; other site 74547003319 helicase superfamily c-terminal domain; Region: HELICc; smart00490 74547003320 ATP-binding site [chemical binding]; other site 74547003321 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 74547003322 rRNA binding site [nucleotide binding]; other site 74547003323 predicted 30S ribosome binding site; other site 74547003324 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 74547003325 pseudouridine synthase; Region: TIGR00093 74547003326 active site 74547003327 Methyltransferase domain; Region: Methyltransf_31; pfam13847 74547003328 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 74547003329 S-adenosylmethionine binding site [chemical binding]; other site 74547003330 Ycf39; Provisional; Region: ycf39; CHL00194 74547003331 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 74547003332 NAD(P) binding site [chemical binding]; other site 74547003333 putative active site [active] 74547003334 cytochrome b6-f complex subunit PetM; Reviewed; Region: petM; PRK11876 74547003335 N2,N2-dimethylguanosine tRNA methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TRM1; COG1867 74547003336 hydrolase, alpha/beta fold family protein; Region: PLN02824 74547003337 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 74547003338 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 74547003339 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 74547003340 putative valine binding site [chemical binding]; other site 74547003341 dimer interface [polypeptide binding]; other site 74547003342 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 74547003343 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 74547003344 active site 74547003345 photosystem I assembly protein Ycf4; Provisional; Region: PRK02542 74547003346 2 probable transmembrane helices predicted by TMHMM2.0 74547003347 D1, D2 subunits of photosystem II (PSII); M, L subunits of bacterial photosynthetic reaction center; Region: Photo_RC; cl08220 74547003348 pheophytin binding site; other site 74547003349 chlorophyll binding site; other site 74547003350 quinone binding site; other site 74547003351 Fe binding site [ion binding]; other site 74547003352 6 probable transmembrane helices predicted by TMHMM2.0 74547003353 Photosystem II protein; Region: PSII; cl08223 74547003354 photosystem II 44 kDa subunit reaction center protein (also called P6 protein, CP43), bacterial and chloroplast; Region: psbC; TIGR01153 74547003355 7 probable transmembrane helices predicted by TMHMM2.0 74547003356 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 74547003357 active site 74547003358 dimer interface [polypeptide binding]; other site 74547003359 cobyric acid synthase; Provisional; Region: PRK00784 74547003360 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 74547003361 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 74547003362 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 74547003363 catalytic triad [active] 74547003364 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 74547003365 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 74547003366 catalytic loop [active] 74547003367 iron binding site [ion binding]; other site 74547003368 Leucine carboxyl methyltransferase; Region: LCM; cl01306 74547003369 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 74547003370 catalytic triad [active] 74547003371 dimer interface [polypeptide binding]; other site 74547003372 DnaA N-terminal domain; Region: DnaA_N; pfam11638 74547003373 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 74547003374 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 74547003375 Walker A motif; other site 74547003376 ATP binding site [chemical binding]; other site 74547003377 Walker B motif; other site 74547003378 arginine finger; other site 74547003379 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 74547003380 DnaA box-binding interface [nucleotide binding]; other site 74547003381 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 74547003382 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 74547003383 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 74547003384 protein binding site [polypeptide binding]; other site 74547003385 transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282 74547003386 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 74547003387 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 74547003388 Probable Catalytic site; other site 74547003389 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 74547003390 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 74547003391 Coenzyme A binding pocket [chemical binding]; other site 74547003392 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 74547003393 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 74547003394 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 74547003395 Walker A/P-loop; other site 74547003396 ATP binding site [chemical binding]; other site 74547003397 Q-loop/lid; other site 74547003398 ABC transporter signature motif; other site 74547003399 Walker B; other site 74547003400 D-loop; other site 74547003401 H-loop/switch region; other site 74547003402 5 probable transmembrane helices predicted by TMHMM2.0 74547003403 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 74547003404 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 74547003405 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 74547003406 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 74547003407 homotrimer interaction site [polypeptide binding]; other site 74547003408 putative active site [active] 74547003409 Protein of unknown function (DUF3136); Region: DUF3136; pfam11334 74547003410 probable Rubsico expression protein CbbX; Region: cbbX_cfxQ; TIGR02880 74547003411 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 74547003412 Walker A motif; other site 74547003413 ATP binding site [chemical binding]; other site 74547003414 Walker B motif; other site 74547003415 arginine finger; other site 74547003416 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cl00942 74547003417 aromatic arch; other site 74547003418 DCoH dimer interaction site [polypeptide binding]; other site 74547003419 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 74547003420 DCoH tetramer interaction site [polypeptide binding]; other site 74547003421 substrate binding site [chemical binding]; other site 74547003422 Carboxysome Shell 1 (CsoS1); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CsoS1; cd07058 74547003423 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 74547003424 Hexamer interface [polypeptide binding]; other site 74547003425 Hexagonal pore residue; other site 74547003426 Hexagonal pore; other site 74547003427 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 74547003428 Hexamer/Pentamer interface [polypeptide binding]; other site 74547003429 central pore; other site 74547003430 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 74547003431 Hexamer/Pentamer interface [polypeptide binding]; other site 74547003432 central pore; other site 74547003433 Carboxysome Shell Carbonic Anhydrase; Region: CsoSCA; pfam08936 74547003434 Carboxysome shell peptide mid-region; Region: CsoS2_M; pfam12288 74547003435 Carboxysome shell peptide mid-region; Region: CsoS2_M; pfam12288 74547003436 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527 74547003437 multimerization interface [polypeptide binding]; other site 74547003438 ribulose bisophosphate carboxylase; Reviewed; Region: rbcL; PRK04208 74547003439 Ribulose bisphosphate carboxylase large chain; Region: RuBisCO_large; cl08232 74547003440 dimer interface [polypeptide binding]; other site 74547003441 catalytic residue [active] 74547003442 metal binding site [ion binding]; metal-binding site 74547003443 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 74547003444 Carboxysome Shell 1 (CsoS1); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CsoS1; cd07058 74547003445 Hexamer interface [polypeptide binding]; other site 74547003446 Hexagonal pore residue; other site 74547003447 Hexagonal pore; other site 74547003448 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 74547003449 active site 74547003450 dimerization interface [polypeptide binding]; other site 74547003451 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 1; Region: BMC_like_1_repeat1; cd07051 74547003452 putative hexamer interface [polypeptide binding]; other site 74547003453 putative hexagonal pore; other site 74547003454 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 2; Region: BMC_like_1_repeat2; cd07052 74547003455 putative hexamer interface [polypeptide binding]; other site 74547003456 putative hexagonal pore; other site 74547003457 hypothetical 74547003458 Nitrogen regulatory protein P-II; Region: P-II; cl00412 74547003459 Domain of unknown function (DUF897); Region: DUF897; pfam05982 74547003460 9 probable transmembrane helices predicted by TMHMM2.0 74547003461 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 74547003462 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 74547003463 Sulfate transporter family; Region: Sulfate_transp; pfam00916 74547003464 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 74547003465 11 probable transmembrane helices predicted by TMHMM2.0 74547003466 Pchlide_reductase_N: N protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_N; cd01979 74547003467 light-independent protochlorophyllide reductase, N subunit; Region: DPOR_bchN; TIGR01279 74547003468 light-independent protochlorophyllide reductase subunit B; Provisional; Region: PRK02910 74547003469 Pchlide_reductase_B: B protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_B; cd01981 74547003470 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 74547003471 protochlorophyllide reductase iron-sulfur ATP-binding protein; Provisional; Region: chlL; PRK13185 74547003472 This family of proteins contains bchL and chlL. Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. Three genes, bchL, bchN and bchB, are...; Region: Bchl_like; cd02032 74547003473 P-loop; other site 74547003474 protochlorophyllide oxidoreductase; Validated; Region: PRK07453 74547003475 light-dependent protochlorophyllide reductase; Region: LPOR; TIGR01289 74547003476 NAD(P) binding site [chemical binding]; other site 74547003477 active site 74547003478 1 probable transmembrane helix predicted for by TMHMM2.0 74547003479 Photosystem I protein M (PsaM); Region: PsaM; cl15374 74547003480 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 74547003481 7 probable transmembrane helices predicted by TMHMM2.0 74547003482 hypothetical 74547003483 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 74547003484 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 74547003485 active site 74547003486 putative substrate binding region [chemical binding]; other site 74547003487 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 74547003488 6 probable transmembrane helices predicted by TMHMM2.0 74547003489 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 74547003490 active site 74547003491 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 74547003492 GTP cyclohydrolase I; Provisional; Region: PLN03044 74547003493 active site 74547003494 short chain dehydrogenase; Provisional; Region: PRK07454 74547003495 classical (c) SDRs; Region: SDR_c; cd05233 74547003496 NAD(P) binding site [chemical binding]; other site 74547003497 active site 74547003498 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 74547003499 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 74547003500 acyl-ACP reductase; Provisional; Region: PRK14982 74547003501 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 74547003502 NAD(P) binding pocket [chemical binding]; other site 74547003503 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 74547003504 dinuclear metal binding motif [ion binding]; other site 74547003505 Creatinine amidohydrolase; Region: Creatininase; pfam02633 74547003506 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 74547003507 RNA binding site [nucleotide binding]; other site 74547003508 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 74547003509 RNA binding site [nucleotide binding]; other site 74547003510 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 74547003511 RNA binding site [nucleotide binding]; other site 74547003512 Protein of unknown function (DUF1092); Region: DUF1092; pfam06485 74547003513 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 74547003514 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 74547003515 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 74547003516 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 74547003517 ligand binding site [chemical binding]; other site 74547003518 1 probable transmembrane helix predicted for by TMHMM2.0 74547003519 acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK07418 74547003520 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 74547003521 PYR/PP interface [polypeptide binding]; other site 74547003522 dimer interface [polypeptide binding]; other site 74547003523 TPP binding site [chemical binding]; other site 74547003524 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 74547003525 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 74547003526 TPP-binding site [chemical binding]; other site 74547003527 dimer interface [polypeptide binding]; other site 74547003528 ferrochelatase; Reviewed; Region: hemH; PRK00035 74547003529 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 74547003530 C-terminal domain interface [polypeptide binding]; other site 74547003531 active site 74547003532 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 74547003533 active site 74547003534 N-terminal domain interface [polypeptide binding]; other site 74547003535 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 74547003536 active site 74547003537 catalytic residues [active] 74547003538 DNA binding site [nucleotide binding] 74547003539 Int/Topo IB signature motif; other site 74547003540 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 74547003541 S-adenosylmethionine binding site [chemical binding]; other site 74547003542 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 74547003543 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 74547003544 homodimer interface [polypeptide binding]; other site 74547003545 Walker A motif; other site 74547003546 ATP binding site [chemical binding]; other site 74547003547 hydroxycobalamin binding site [chemical binding]; other site 74547003548 Walker B motif; other site 74547003549 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 74547003550 putative nucleotide binding site [chemical binding]; other site 74547003551 uridine monophosphate binding site [chemical binding]; other site 74547003552 homohexameric interface [polypeptide binding]; other site 74547003553 ribosome recycling factor; Reviewed; Region: frr; PRK00083 74547003554 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 74547003555 hinge region; other site 74547003556 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 74547003557 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 74547003558 C factor cell-cell signaling protein; Provisional; Region: PRK09009 74547003559 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 74547003560 NADP binding site [chemical binding]; other site 74547003561 homodimer interface [polypeptide binding]; other site 74547003562 active site 74547003563 transaldolase/EF-hand domain-containing protein; Provisional; Region: PRK12309 74547003564 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 74547003565 active site 74547003566 dimer interface [polypeptide binding]; other site 74547003567 catalytic residue [active] 74547003568 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 74547003569 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 74547003570 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 74547003571 1 probable transmembrane helix predicted for by TMHMM2.0 74547003572 1 probable transmembrane helix predicted for by TMHMM2.0 74547003573 CAAX protease self-immunity; Region: Abi; pfam02517 74547003574 8 probable transmembrane helices predicted by TMHMM2.0 74547003575 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 74547003576 catalytic core [active] 74547003577 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 74547003578 catalytic core [active] 74547003579 dihydroorotase; Provisional; Region: PRK07369 74547003580 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 74547003581 active site 74547003582 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 74547003583 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 74547003584 Catalytic site [active] 74547003585 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 74547003586 1 probable transmembrane helix predicted for by TMHMM2.0 74547003587 1 probable transmembrane helix predicted for by TMHMM2.0 74547003588 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 74547003589 ArsC family; Region: ArsC; pfam03960 74547003590 putative ArsC-like catalytic residues; other site 74547003591 putative TRX-like catalytic residues [active] 74547003592 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 74547003593 dimer interface [polypeptide binding]; other site 74547003594 substrate binding site [chemical binding]; other site 74547003595 metal binding sites [ion binding]; metal-binding site 74547003596 prolyl-tRNA synthetase; Provisional; Region: PRK09194 74547003597 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 74547003598 dimer interface [polypeptide binding]; other site 74547003599 motif 1; other site 74547003600 active site 74547003601 motif 2; other site 74547003602 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 74547003603 putative deacylase active site [active] 74547003604 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 74547003605 active site 74547003606 motif 3; other site 74547003607 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 74547003608 anticodon binding site; other site 74547003609 photosystem II protein Psb27; Region: PS_II_psb27; TIGR03044 74547003610 1 probable transmembrane helix predicted for by TMHMM2.0 74547003611 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 74547003612 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 74547003613 GDP-binding site [chemical binding]; other site 74547003614 ACT binding site; other site 74547003615 IMP binding site; other site 74547003616 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 74547003617 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 74547003618 substrate binding site [chemical binding]; other site 74547003619 ATP binding site [chemical binding]; other site 74547003620 CutA1 divalent ion tolerance protein; Region: CutA1; cl00584 74547003621 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 74547003622 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 74547003623 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 74547003624 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 74547003625 dimer interface [polypeptide binding]; other site 74547003626 ssDNA binding site [nucleotide binding]; other site 74547003627 tetramer (dimer of dimers) interface [polypeptide binding]; other site 74547003628 Protein of unknown function (DUF2854); Region: DUF2854; pfam11016 74547003629 2 probable transmembrane helices predicted by TMHMM2.0 74547003630 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 74547003631 feedback inhibition sensing region; other site 74547003632 homohexameric interface [polypeptide binding]; other site 74547003633 nucleotide binding site [chemical binding]; other site 74547003634 N-acetyl-L-glutamate binding site [chemical binding]; other site 74547003635 1 probable transmembrane helix predicted for by TMHMM2.0 74547003636 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 74547003637 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 74547003638 ATP binding site [chemical binding]; other site 74547003639 putative Mg++ binding site [ion binding]; other site 74547003640 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 74547003641 nucleotide binding region [chemical binding]; other site 74547003642 ATP-binding site [chemical binding]; other site 74547003643 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 74547003644 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 74547003645 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 74547003646 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 74547003647 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 74547003648 DNA binding residues [nucleotide binding] 74547003649 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 74547003650 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 74547003651 domain interfaces; other site 74547003652 active site 74547003653 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 74547003654 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 74547003655 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 74547003656 dimer interface [polypeptide binding]; other site 74547003657 substrate binding site [chemical binding]; other site 74547003658 metal binding sites [ion binding]; metal-binding site 74547003659 1 probable transmembrane helix predicted for by TMHMM2.0 74547003660 1 probable transmembrane helix predicted for by TMHMM2.0 74547003661 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 74547003662 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 74547003663 active site 74547003664 Zn binding site [ion binding]; other site 74547003665 Protein of unknown function, DUF393; Region: DUF393; pfam04134 74547003666 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 74547003667 hypothetical protein; Region: PHA01748 74547003668 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914 74547003669 aromatic arch; other site 74547003670 DCoH dimer interaction site [polypeptide binding]; other site 74547003671 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 74547003672 DCoH tetramer interaction site [polypeptide binding]; other site 74547003673 substrate binding site [chemical binding]; other site 74547003674 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 74547003675 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 74547003676 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 74547003677 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 74547003678 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 74547003679 dimer interface [polypeptide binding]; other site 74547003680 conserved gate region; other site 74547003681 putative PBP binding loops; other site 74547003682 ABC-ATPase subunit interface; other site 74547003683 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 74547003684 dimer interface [polypeptide binding]; other site 74547003685 conserved gate region; other site 74547003686 putative PBP binding loops; other site 74547003687 ABC-ATPase subunit interface; other site 74547003688 11 probable transmembrane helices predicted by TMHMM2.0 74547003689 Putative 2OG-Fe(II) oxygenase; Region: 2OG-FeII_Oxy_5; pfam13759 74547003690 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 74547003691 active site 74547003692 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 74547003693 7 probable transmembrane helices predicted by TMHMM2.0 74547003694 hypothetical protein; Provisional; Region: PRK04194 74547003695 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 74547003696 1 probable transmembrane helix predicted for by TMHMM2.0 74547003697 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 74547003698 putative catalytic site [active] 74547003699 putative phosphate binding site [ion binding]; other site 74547003700 active site 74547003701 metal binding site A [ion binding]; metal-binding site 74547003702 DNA binding site [nucleotide binding] 74547003703 putative AP binding site [nucleotide binding]; other site 74547003704 putative metal binding site B [ion binding]; other site 74547003705 FAD binding domain; Region: FAD_binding_4; pfam01565 74547003706 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 74547003707 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 74547003708 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 74547003709 inhibitor-cofactor binding pocket; inhibition site 74547003710 pyridoxal 5'-phosphate binding site [chemical binding]; other site 74547003711 catalytic residue [active] 74547003712 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 74547003713 Amidase; Region: Amidase; cl11426 74547003714 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 74547003715 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 74547003716 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 74547003717 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 74547003718 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 74547003719 3 probable transmembrane helices predicted by TMHMM2.0 74547003720 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 74547003721 BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857 74547003722 DRTGG domain; Region: DRTGG; pfam07085 74547003723 short chain dehydrogenase; Provisional; Region: PRK12367 74547003724 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 74547003725 active site 74547003726 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 74547003727 Src Homology 3 domain superfamily; Region: SH3; cl17036 74547003728 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 74547003729 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 74547003730 HIGH motif; other site 74547003731 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 74547003732 active site 74547003733 KMSKS motif; other site 74547003734 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 74547003735 10 probable transmembrane helices predicted by TMHMM2.0 74547003736 Protein of unknown function (DUF1643); Region: DUF1643; pfam07799 74547003737 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 74547003738 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 74547003739 active site 74547003740 homodimer interface [polypeptide binding]; other site 74547003741 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 74547003742 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 74547003743 Walker A motif; other site 74547003744 ATP binding site [chemical binding]; other site 74547003745 Walker B motif; other site 74547003746 1 probable transmembrane helix predicted for by TMHMM2.0 74547003747 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 74547003748 tRNA threonylcarbamoyl adenosine modification protein YgjD; Region: T6A_YgjD; TIGR03723 74547003749 Photosystem I reaction centre subunit III; Region: PSI_PsaF; cl03627 74547003750 2 probable transmembrane helices predicted by TMHMM2.0 74547003751 photosystem I reaction center subunit IX; Provisional; Region: PRK02733 74547003752 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 74547003753 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 74547003754 catalytic site [active] 74547003755 G-X2-G-X-G-K; other site 74547003756 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 74547003757 Domain of unknown function (DUF814); Region: DUF814; pfam05670 74547003758 Sec-independent translocase component C; Provisional; Region: tatC; CHL00182 74547003759 6 probable transmembrane helices predicted by TMHMM2.0 74547003760 cytochrome b6-f complex iron-sulfur subunit; Provisional; Region: PRK13474 74547003761 Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802 74547003762 Iron-sulfur protein (ISP) component of the b6f complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The cytochrome b6f complex from Mastigocladus laminosus, a thermophilic cyanobacterium; Region: Rieske_cytochrome_b6f; cd03471 74547003763 cytochrome b subunit interaction site [polypeptide binding]; other site 74547003764 [2Fe-2S] cluster binding site [ion binding]; other site 74547003765 apocytochrome f; Reviewed; Region: PRK02693 74547003766 cytochrome f; Region: petA; CHL00037 74547003767 2 probable transmembrane helices predicted by TMHMM2.0 74547003768 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 74547003769 7 probable transmembrane helices predicted by TMHMM2.0 74547003770 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 74547003771 active site 74547003772 SAM binding site [chemical binding]; other site 74547003773 homodimer interface [polypeptide binding]; other site 74547003774 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 74547003775 non-specific DNA binding site [nucleotide binding]; other site 74547003776 salt bridge; other site 74547003777 sequence-specific DNA binding site [nucleotide binding]; other site 74547003778 1 probable transmembrane helix predicted for by TMHMM2.0 74547003779 exopolyphosphatase; Region: exo_poly_only; TIGR03706 74547003780 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 74547003781 prenyltransferase; Reviewed; Region: ubiA; PRK12873 74547003782 UbiA prenyltransferase family; Region: UbiA; pfam01040 74547003783 7 probable transmembrane helices predicted by TMHMM2.0 74547003784 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 74547003785 dimer interface [polypeptide binding]; other site 74547003786 catalytic triad [active] 74547003787 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 74547003788 substrate binding site; other site 74547003789 dimer interface; other site 74547003790 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 74547003791 Ion channel; Region: Ion_trans_2; pfam07885 74547003792 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 74547003793 TrkA-N domain; Region: TrkA_N; pfam02254 74547003794 TrkA-C domain; Region: TrkA_C; pfam02080 74547003795 3 probable transmembrane helices predicted by TMHMM2.0 74547003796 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 74547003797 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 74547003798 NAD(P) binding site [chemical binding]; other site 74547003799 active site 74547003800 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 74547003801 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 74547003802 ring oligomerisation interface [polypeptide binding]; other site 74547003803 ATP/Mg binding site [chemical binding]; other site 74547003804 stacking interactions; other site 74547003805 hinge regions; other site 74547003806 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 74547003807 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 74547003808 putative active site cavity [active] 74547003809 ABC-2 type transporter; Region: ABC2_membrane; cl17235 74547003810 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 74547003811 6 probable transmembrane helices predicted by TMHMM2.0 74547003812 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 74547003813 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 74547003814 Walker A/P-loop; other site 74547003815 ATP binding site [chemical binding]; other site 74547003816 Q-loop/lid; other site 74547003817 ABC transporter signature motif; other site 74547003818 Walker B; other site 74547003819 D-loop; other site 74547003820 H-loop/switch region; other site 74547003821 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 74547003822 UbiA prenyltransferase family; Region: UbiA; pfam01040 74547003823 7 probable transmembrane helices predicted by TMHMM2.0 74547003824 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 74547003825 8 probable transmembrane helices predicted by TMHMM2.0 74547003826 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 74547003827 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 74547003828 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 74547003829 3 probable transmembrane helices predicted by TMHMM2.0 74547003830 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 74547003831 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 74547003832 12 probable transmembrane helices predicted by TMHMM2.0 74547003833 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 74547003834 Subunit I/III interface [polypeptide binding]; other site 74547003835 4 probable transmembrane helices predicted by TMHMM2.0 74547003836 AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250 74547003837 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 74547003838 6 probable transmembrane helices predicted by TMHMM2.0 74547003839 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 74547003840 Lumazine binding domain; Region: Lum_binding; pfam00677 74547003841 Lumazine binding domain; Region: Lum_binding; pfam00677 74547003842 Bifunctional nuclease; Region: DNase-RNase; pfam02577 74547003843 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 74547003844 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 74547003845 active site 74547003846 catalytic tetrad [active] 74547003847 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 74547003848 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 74547003849 active site pocket [active] 74547003850 4 probable transmembrane helices predicted by TMHMM2.0 74547003851 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 74547003852 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 74547003853 active site 74547003854 interdomain interaction site; other site 74547003855 putative metal-binding site [ion binding]; other site 74547003856 nucleotide binding site [chemical binding]; other site 74547003857 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 74547003858 domain I; other site 74547003859 phosphate binding site [ion binding]; other site 74547003860 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 74547003861 domain II; other site 74547003862 domain III; other site 74547003863 nucleotide binding site [chemical binding]; other site 74547003864 DNA binding groove [nucleotide binding] 74547003865 catalytic site [active] 74547003866 domain IV; other site 74547003867 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 74547003868 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 74547003869 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 74547003870 NAD(P)H-quinone oxidoreductase subunit 2; Provisional; Region: PRK02504 74547003871 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 74547003872 14 probable transmembrane helices predicted by TMHMM2.0 74547003873 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 74547003874 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 74547003875 Walker A/P-loop; other site 74547003876 ATP binding site [chemical binding]; other site 74547003877 Q-loop/lid; other site 74547003878 ABC transporter signature motif; other site 74547003879 Walker B; other site 74547003880 D-loop; other site 74547003881 H-loop/switch region; other site 74547003882 Response regulator receiver domain; Region: Response_reg; pfam00072 74547003883 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 74547003884 active site 74547003885 phosphorylation site [posttranslational modification] 74547003886 intermolecular recognition site; other site 74547003887 dimerization interface [polypeptide binding]; other site 74547003888 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 74547003889 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 74547003890 active site 74547003891 phosphorylation site [posttranslational modification] 74547003892 intermolecular recognition site; other site 74547003893 dimerization interface [polypeptide binding]; other site 74547003894 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 74547003895 DNA binding site [nucleotide binding] 74547003896 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 74547003897 Peptidase family M23; Region: Peptidase_M23; pfam01551 74547003898 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 74547003899 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 74547003900 succinyldiaminopimelate transaminase; Validated; Region: PRK07366 74547003901 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 74547003902 pyridoxal 5'-phosphate binding site [chemical binding]; other site 74547003903 homodimer interface [polypeptide binding]; other site 74547003904 catalytic residue [active] 74547003905 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 74547003906 Protein of unknown function (DUF721); Region: DUF721; pfam05258 74547003907 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 74547003908 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 74547003909 11 probable transmembrane helices predicted by TMHMM2.0 74547003910 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 74547003911 EamA-like transporter family; Region: EamA; pfam00892 74547003912 EamA-like transporter family; Region: EamA; pfam00892 74547003913 10 probable transmembrane helices predicted by TMHMM2.0 74547003914 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 74547003915 tandem repeat interface [polypeptide binding]; other site 74547003916 oligomer interface [polypeptide binding]; other site 74547003917 active site residues [active] 74547003918 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 74547003919 homotrimer interaction site [polypeptide binding]; other site 74547003920 active site 74547003921 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 74547003922 Ribonuclease P; Region: Ribonuclease_P; cl00457 74547003923 Bacterial PH domain; Region: DUF304; pfam03703 74547003924 1 probable transmembrane helix predicted for by TMHMM2.0 74547003925 putative inner membrane protein translocase component YidC; Provisional; Region: PRK02654 74547003926 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 74547003927 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 74547003928 3 probable transmembrane helices predicted by TMHMM2.0 74547003929 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 74547003930 Ycf46; Provisional; Region: ycf46; CHL00195 74547003931 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 74547003932 Walker A motif; other site 74547003933 ATP binding site [chemical binding]; other site 74547003934 Walker B motif; other site 74547003935 arginine finger; other site 74547003936 seryl-tRNA synthetase; Provisional; Region: PRK05431 74547003937 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 74547003938 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 74547003939 dimer interface [polypeptide binding]; other site 74547003940 active site 74547003941 motif 1; other site 74547003942 motif 2; other site 74547003943 motif 3; other site 74547003944 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 74547003945 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 74547003946 active site 74547003947 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 74547003948 putative substrate binding region [chemical binding]; other site 74547003949 3 probable transmembrane helices predicted by TMHMM2.0 74547003950 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 74547003951 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 74547003952 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 74547003953 RNase E interface [polypeptide binding]; other site 74547003954 trimer interface [polypeptide binding]; other site 74547003955 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 74547003956 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 74547003957 RNase E interface [polypeptide binding]; other site 74547003958 trimer interface [polypeptide binding]; other site 74547003959 active site 74547003960 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 74547003961 putative nucleic acid binding region [nucleotide binding]; other site 74547003962 G-X-X-G motif; other site 74547003963 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 74547003964 RNA binding site [nucleotide binding]; other site 74547003965 domain interface; other site 74547003966 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 74547003967 active site 74547003968 Predicted methyltransferases [General function prediction only]; Region: COG0313 74547003969 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 74547003970 putative SAM binding site [chemical binding]; other site 74547003971 putative homodimer interface [polypeptide binding]; other site 74547003972 2 probable transmembrane helices predicted by TMHMM2.0 74547003973 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 74547003974 3 probable transmembrane helices predicted by TMHMM2.0 74547003975 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 74547003976 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 74547003977 1 probable transmembrane helix predicted for by TMHMM2.0 74547003978 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 74547003979 Uncharacterized conserved protein [Function unknown]; Region: COG0397 74547003980 hypothetical protein; Validated; Region: PRK00029 74547003981 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 74547003982 active site 74547003983 HIGH motif; other site 74547003984 nucleotide binding site [chemical binding]; other site 74547003985 active site 74547003986 KMSKS motif; other site 74547003987 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 74547003988 IHF dimer interface [polypeptide binding]; other site 74547003989 IHF - DNA interface [nucleotide binding]; other site 74547003990 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 74547003991 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 74547003992 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 74547003993 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 74547003994 active site 74547003995 catalytic site [active] 74547003996 MFS/sugar transport protein; Region: MFS_2; pfam13347 74547003997 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 74547003998 11 probable transmembrane helices predicted by TMHMM2.0 74547003999 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 74547004000 Permease; Region: Permease; pfam02405 74547004001 5 probable transmembrane helices predicted by TMHMM2.0 74547004002 Protein of unknown function (DUF3086); Region: DUF3086; pfam11285 74547004003 membrane protein; Provisional; Region: PRK14419 74547004004 3 probable transmembrane helices predicted by TMHMM2.0 74547004005 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 74547004006 active site 74547004007 dimer interface [polypeptide binding]; other site 74547004008 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 74547004009 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 74547004010 active site 74547004011 HIGH motif; other site 74547004012 dimer interface [polypeptide binding]; other site 74547004013 KMSKS motif; other site 74547004014 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 74547004015 RNA binding surface [nucleotide binding]; other site 74547004016 Domain of unknown function (DUF1825); Region: DUF1825; pfam08855 74547004017 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 74547004018 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 74547004019 DNA binding residues [nucleotide binding] 74547004020 dimerization interface [polypeptide binding]; other site 74547004021 multifunctional aminopeptidase A; Provisional; Region: PRK00913 74547004022 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 74547004023 interface (dimer of trimers) [polypeptide binding]; other site 74547004024 Substrate-binding/catalytic site; other site 74547004025 Zn-binding sites [ion binding]; other site 74547004026 Peptide methionine sulfoxide reductase; Region: PMSR; pfam01625 74547004027 1 probable transmembrane helix predicted for by TMHMM2.0 74547004028 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 74547004029 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 74547004030 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 74547004031 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 74547004032 active site 74547004033 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 74547004034 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 74547004035 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 74547004036 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 74547004037 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 74547004038 Surface antigen; Region: Bac_surface_Ag; pfam01103 74547004039 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 74547004040 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 74547004041 ATP binding site [chemical binding]; other site 74547004042 active site 74547004043 substrate binding site [chemical binding]; other site 74547004044 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 74547004045 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 74547004046 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 74547004047 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 74547004048 HAMP domain; Region: HAMP; pfam00672 74547004049 dimerization interface [polypeptide binding]; other site 74547004050 PAS domain; Region: PAS; smart00091 74547004051 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 74547004052 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 74547004053 dimer interface [polypeptide binding]; other site 74547004054 phosphorylation site [posttranslational modification] 74547004055 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 74547004056 ATP binding site [chemical binding]; other site 74547004057 Mg2+ binding site [ion binding]; other site 74547004058 G-X-G motif; other site 74547004059 2 probable transmembrane helices predicted by TMHMM2.0 74547004060 circadian clock protein KaiC; Region: circ_KaiC; TIGR02655 74547004061 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 74547004062 KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124 74547004063 Walker A motif; other site 74547004064 Walker A motif; other site 74547004065 ATP binding site [chemical binding]; other site 74547004066 Walker B motif; other site 74547004067 recA bacterial DNA recombination protein; Region: RecA; cl17211 74547004068 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 74547004069 Walker A motif; other site 74547004070 ATP binding site [chemical binding]; other site 74547004071 Walker B motif; other site 74547004072 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 74547004073 tetramer interface [polypeptide binding]; other site 74547004074 dimer interface [polypeptide binding]; other site 74547004075 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 74547004076 ribosomal protein L21; Region: rpl21; CHL00075 74547004077 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 74547004078 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02755 74547004079 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 74547004080 RNA binding site [nucleotide binding]; other site 74547004081 active site 74547004082 hypothetical protein; Validated; Region: PRK00110 74547004083 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 74547004084 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 74547004085 active site 74547004086 trimer interface [polypeptide binding]; other site 74547004087 allosteric site; other site 74547004088 active site lid [active] 74547004089 hexamer (dimer of trimers) interface [polypeptide binding]; other site 74547004090 Stage II sporulation protein; Region: SpoIID; pfam08486 74547004091 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 74547004092 ribonuclease Z; Region: RNase_Z; TIGR02651 74547004093 cytochrome c-550; Provisional; Region: psbV; PRK13617 74547004094 1 probable transmembrane helix predicted for by TMHMM2.0 74547004095 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 74547004096 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 74547004097 catalytic loop [active] 74547004098 iron binding site [ion binding]; other site 74547004099 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 74547004100 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 74547004101 S-adenosylmethionine binding site [chemical binding]; other site 74547004102 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 74547004103 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 74547004104 ligand binding site [chemical binding]; other site 74547004105 NAD binding site [chemical binding]; other site 74547004106 dimerization interface [polypeptide binding]; other site 74547004107 catalytic site [active] 74547004108 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 74547004109 putative L-serine binding site [chemical binding]; other site 74547004110 2 probable transmembrane helices predicted by TMHMM2.0 74547004111 photosystem II S4 domain protein; Region: PS_II_S4; TIGR03069 74547004112 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 74547004113 RNA binding surface [nucleotide binding]; other site 74547004114 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02705 74547004115 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 74547004116 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 74547004117 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 74547004118 Protein of unknown function (DUF4090); Region: DUF4090; pfam13319 74547004119 Membrane transport protein; Region: Mem_trans; cl09117 74547004120 8 probable transmembrane helices predicted by TMHMM2.0 74547004121 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 74547004122 EVE domain; Region: EVE; cl00728 74547004123 Protein of unknown function (DUF2811); Region: DUF2811; pfam10929 74547004124 Domain of unknown function (DUF1818); Region: DUF1818; pfam08848 74547004125 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 74547004126 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 74547004127 nucleotide binding site [chemical binding]; other site 74547004128 putative NEF/HSP70 interaction site [polypeptide binding]; other site 74547004129 SBD interface [polypeptide binding]; other site 74547004130 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 74547004131 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 74547004132 active site 74547004133 phosphoglyceromutase; Provisional; Region: PRK05434 74547004134 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 74547004135 2 probable transmembrane helices predicted by TMHMM2.0 74547004136 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 74547004137 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 74547004138 ring oligomerisation interface [polypeptide binding]; other site 74547004139 ATP/Mg binding site [chemical binding]; other site 74547004140 stacking interactions; other site 74547004141 hinge regions; other site 74547004142 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 74547004143 oligomerisation interface [polypeptide binding]; other site 74547004144 mobile loop; other site 74547004145 roof hairpin; other site 74547004146 ATP synthase CF1 beta subunit; Region: atpB; CHL00060 74547004147 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 74547004148 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 74547004149 alpha subunit interaction interface [polypeptide binding]; other site 74547004150 Walker A motif; other site 74547004151 ATP binding site [chemical binding]; other site 74547004152 Walker B motif; other site 74547004153 inhibitor binding site; inhibition site 74547004154 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 74547004155 ATP synthase CF1 epsilon subunit; Region: atpE; CHL00063 74547004156 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 74547004157 gamma subunit interface [polypeptide binding]; other site 74547004158 epsilon subunit interface [polypeptide binding]; other site 74547004159 LBP interface [polypeptide binding]; other site 74547004160 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 74547004161 active site 74547004162 intersubunit interactions; other site 74547004163 catalytic residue [active] 74547004164 hypothetical protein; Provisional; Region: PRK02724 74547004165 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 74547004166 haloacid dehalogenase superfamily, subfamily IA hydrolase, TIGR01548; Region: HAD-SF-IA-hyp1 74547004167 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 74547004168 proline aminopeptidase P II; Provisional; Region: PRK10879 74547004169 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 74547004170 active site 74547004171 Domain of unknown function DUF21; Region: DUF21; pfam01595 74547004172 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 74547004173 4 probable transmembrane helices predicted by TMHMM2.0 74547004174 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 74547004175 G1 box; other site 74547004176 GTP/Mg2+ binding site [chemical binding]; other site 74547004177 Switch I region; other site 74547004178 G2 box; other site 74547004179 Switch II region; other site 74547004180 G3 box; other site 74547004181 G4 box; other site 74547004182 Domain of unknown function (DUF697); Region: DUF697; pfam05128 74547004183 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 74547004184 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 74547004185 active site 74547004186 (T/H)XGH motif; other site 74547004187 NAD synthetase; Provisional; Region: PRK13981 74547004188 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 74547004189 multimer interface [polypeptide binding]; other site 74547004190 active site 74547004191 catalytic triad [active] 74547004192 protein interface 1 [polypeptide binding]; other site 74547004193 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 74547004194 homodimer interface [polypeptide binding]; other site 74547004195 NAD binding pocket [chemical binding]; other site 74547004196 ATP binding pocket [chemical binding]; other site 74547004197 Mg binding site [ion binding]; other site 74547004198 active-site loop [active] 74547004199 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 74547004200 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 74547004201 hexamer interface [polypeptide binding]; other site 74547004202 ligand binding site [chemical binding]; other site 74547004203 putative active site [active] 74547004204 NAD(P) binding site [chemical binding]; other site 74547004205 Protein of unknown function (DUF3326); Region: DUF3326; pfam11805 74547004206 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 74547004207 core domain interface [polypeptide binding]; other site 74547004208 delta subunit interface [polypeptide binding]; other site 74547004209 epsilon subunit interface [polypeptide binding]; other site 74547004210 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 74547004211 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 74547004212 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 74547004213 beta subunit interaction interface [polypeptide binding]; other site 74547004214 Walker A motif; other site 74547004215 ATP binding site [chemical binding]; other site 74547004216 Walker B motif; other site 74547004217 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 74547004218 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 74547004219 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13429 74547004220 F0F1 ATP synthase subunit B; Validated; Region: PRK07352 74547004221 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 74547004222 1 probable transmembrane helix predicted for by TMHMM2.0 74547004223 F0F1 ATP synthase subunit B'; Validated; Region: PRK07353 74547004224 1 probable transmembrane helix predicted for by TMHMM2.0 74547004225 ATP synthase CF0 C subunit; Region: atpH; CHL00061 74547004226 2 probable transmembrane helices predicted by TMHMM2.0 74547004227 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 74547004228 ATP synthase CF0 A subunit; Region: atpI; CHL00046 74547004229 5 probable transmembrane helices predicted by TMHMM2.0 74547004230 ATP synthase I chain; Region: ATP_synt_I; pfam03899 74547004231 3 probable transmembrane helices predicted by TMHMM2.0 74547004232 Methyltransferase domain; Region: Methyltransf_31; pfam13847 74547004233 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 74547004234 S-adenosylmethionine binding site [chemical binding]; other site 74547004235 Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098 74547004236 9 probable transmembrane helices predicted by TMHMM2.0 74547004237 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 74547004238 6 probable transmembrane helices predicted by TMHMM2.0 74547004239 ResB-like family; Region: ResB; pfam05140 74547004240 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 74547004241 4 probable transmembrane helices predicted by TMHMM2.0 74547004242 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 74547004243 Domain of unknown function (DUF4278); Region: DUF4278; pfam14105 74547004244 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 74547004245 Nitrogen regulatory protein P-II; Region: P-II; smart00938 74547004246 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 74547004247 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 74547004248 RNA binding surface [nucleotide binding]; other site 74547004249 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 74547004250 adenylosuccinate lyase; Provisional; Region: PRK07380 74547004251 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 74547004252 tetramer interface [polypeptide binding]; other site 74547004253 active site 74547004254 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 74547004255 fumarate hydratase; Reviewed; Region: fumC; PRK00485 74547004256 Class II fumarases; Region: Fumarase_classII; cd01362 74547004257 active site 74547004258 tetramer interface [polypeptide binding]; other site 74547004259 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 74547004260 Major Facilitator Superfamily; Region: MFS_1; pfam07690 74547004261 putative substrate translocation pore; other site 74547004262 11 probable transmembrane helices predicted by TMHMM2.0 74547004263 DEAD-like helicases superfamily; Region: DEXDc; smart00487 74547004264 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 74547004265 ATP binding site [chemical binding]; other site 74547004266 putative Mg++ binding site [ion binding]; other site 74547004267 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 74547004268 nucleotide binding region [chemical binding]; other site 74547004269 ATP-binding site [chemical binding]; other site 74547004270 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 74547004271 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 74547004272 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 74547004273 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 74547004274 catalytic residue [active] 74547004275 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 74547004276 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 74547004277 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 74547004278 AAA domain; Region: AAA_26; pfam13500 74547004279 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 74547004280 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 74547004281 inhibitor-cofactor binding pocket; inhibition site 74547004282 pyridoxal 5'-phosphate binding site [chemical binding]; other site 74547004283 catalytic residue [active] 74547004284 Protein of unknown function (DUF3143); Region: DUF3143; pfam11341 74547004285 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 74547004286 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 74547004287 HSP70 interaction site [polypeptide binding]; other site 74547004288 1 probable transmembrane helix predicted for by TMHMM2.0 74547004289 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 74547004290 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 74547004291 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 74547004292 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 74547004293 active site 74547004294 catalytic tetrad [active] 74547004295 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 74547004296 Protein of unknown function (DUF1257); Region: DUF1257; pfam06868 74547004297 Protein of unknown function (DUF2997); Region: DUF2997; pfam11211 74547004298 HEAT repeats; Region: HEAT_2; pfam13646 74547004299 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477 74547004300 Na binding site [ion binding]; other site 74547004301 15 probable transmembrane helices predicted by TMHMM2.0 74547004302 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14457 74547004303 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 74547004304 FeS/SAM binding site; other site 74547004305 light-harvesting-like protein 3; Provisional; Region: PLN00014 74547004306 1 probable transmembrane helix predicted for by TMHMM2.0 74547004307 DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597 74547004308 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 74547004309 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 74547004310 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 74547004311 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 74547004312 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 74547004313 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 74547004314 DNA binding site [nucleotide binding] 74547004315 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 74547004316 DNA-directed RNA polymerase subunit gamma; Provisional; Region: rpoC1; PRK02625 74547004317 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 74547004318 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 74547004319 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 74547004320 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 74547004321 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 74547004322 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 74547004323 RPB1 interaction site [polypeptide binding]; other site 74547004324 RPB10 interaction site [polypeptide binding]; other site 74547004325 RPB11 interaction site [polypeptide binding]; other site 74547004326 RPB3 interaction site [polypeptide binding]; other site 74547004327 RPB12 interaction site [polypeptide binding]; other site 74547004328 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 74547004329 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 74547004330 active site 74547004331 ribosomal protein S20; Region: rps20; CHL00102 74547004332 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 74547004333 histidinol dehydrogenase; Region: hisD; TIGR00069 74547004334 NAD binding site [chemical binding]; other site 74547004335 dimerization interface [polypeptide binding]; other site 74547004336 product binding site; other site 74547004337 substrate binding site [chemical binding]; other site 74547004338 zinc binding site [ion binding]; other site 74547004339 catalytic residues [active] 74547004340 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 74547004341 tetramer (dimer of dimers) interface [polypeptide binding]; other site 74547004342 active site 74547004343 dimer interface [polypeptide binding]; other site 74547004344 periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038 74547004345 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 74547004346 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 74547004347 protein binding site [polypeptide binding]; other site 74547004348 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 74547004349 Sulfatase; Region: Sulfatase; pfam00884 74547004350 Uncharacterized conserved protein [Function unknown]; Region: COG1262 74547004351 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 74547004352 extracellular substrate-binding orphan protein, GRRM family; Region: orph_peri_GRRM; TIGR04262 74547004353 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 74547004354 substrate binding pocket [chemical binding]; other site 74547004355 membrane-bound complex binding site; other site 74547004356 hinge residues; other site 74547004357 rSAM-associated Gly-rich repeat protein; Region: Cyano_gly_rpt; TIGR04260 74547004358 radical SAM/SPASM domain protein, GRRM system; Region: rSAM_GlyRichRpt; TIGR04261 74547004359 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 74547004360 FeS/SAM binding site; other site 74547004361 Uncharacterized conserved protein [Function unknown]; Region: COG5361 74547004362 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 74547004363 Protein of unknown function (DUF1214); Region: DUF1214; pfam06742 74547004364 Uncharacterized conserved protein [Function unknown]; Region: COG5361 74547004365 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 74547004366 Protein of unknown function (DUF1214); Region: DUF1214; pfam06742 74547004367 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 74547004368 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 74547004369 Mechanosensitive ion channel; Region: MS_channel; pfam00924 74547004370 4 probable transmembrane helices predicted by TMHMM2.0 74547004371 hypothetical protein; Provisional; Region: PRK14634 74547004372 ribosome maturation protein RimP; Reviewed; Region: PRK00092 74547004373 transcription elongation factor NusA; Provisional; Region: nusA; PRK12329 74547004374 NusA N-terminal domain; Region: NusA_N; pfam08529 74547004375 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 74547004376 RNA binding site [nucleotide binding]; other site 74547004377 homodimer interface [polypeptide binding]; other site 74547004378 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 74547004379 G-X-X-G motif; other site 74547004380 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 74547004381 G-X-X-G motif; other site 74547004382 Protein of unknown function (DUF448); Region: DUF448; pfam04296 74547004383 putative RNA binding cleft [nucleotide binding]; other site 74547004384 translation initiation factor IF-2; Region: IF-2; TIGR00487 74547004385 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 74547004386 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 74547004387 G1 box; other site 74547004388 putative GEF interaction site [polypeptide binding]; other site 74547004389 GTP/Mg2+ binding site [chemical binding]; other site 74547004390 Switch I region; other site 74547004391 G2 box; other site 74547004392 G3 box; other site 74547004393 Switch II region; other site 74547004394 G4 box; other site 74547004395 G5 box; other site 74547004396 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 74547004397 Translation-initiation factor 2; Region: IF-2; pfam11987 74547004398 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 74547004399 4 probable transmembrane helices predicted by TMHMM2.0 74547004400 Domain of unknown function (DUF389); Region: DUF389; pfam04087 74547004401 6 probable transmembrane helices predicted by TMHMM2.0 74547004402 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 74547004403 protein I interface; other site 74547004404 D2 interface; other site 74547004405 protein T interface; other site 74547004406 chlorophyll binding site; other site 74547004407 beta carotene binding site; other site 74547004408 pheophytin binding site; other site 74547004409 manganese-stabilizing polypeptide interface; other site 74547004410 CP43 interface; other site 74547004411 protein L interface; other site 74547004412 oxygen evolving complex binding site; other site 74547004413 bromide binding site; other site 74547004414 quinone binding site; other site 74547004415 Fe binding site [ion binding]; other site 74547004416 core light harvesting interface; other site 74547004417 cytochrome b559 alpha subunit interface; other site 74547004418 cytochrome c-550 interface; other site 74547004419 protein J interface; other site 74547004420 5 probable transmembrane helices predicted by TMHMM2.0 74547004421 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 74547004422 Peptidase M14 Aspartoacylase (ASPA) subfamily; Region: M14_ASPA; cd06909 74547004423 active site 74547004424 Zn binding site [ion binding]; other site 74547004425 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 74547004426 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 74547004427 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 74547004428 putative dimer interface [polypeptide binding]; other site 74547004429 N-terminal domain interface [polypeptide binding]; other site 74547004430 putative substrate binding pocket (H-site) [chemical binding]; other site 74547004431 Uncharacterized integral membrane protein (DUF2301); Region: DUF2301; pfam10063 74547004432 6 probable transmembrane helices predicted by TMHMM2.0 74547004433 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 74547004434 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 74547004435 Walker A/P-loop; other site 74547004436 ATP binding site [chemical binding]; other site 74547004437 Q-loop/lid; other site 74547004438 ABC transporter signature motif; other site 74547004439 Walker B; other site 74547004440 D-loop; other site 74547004441 H-loop/switch region; other site 74547004442 ABC transporter; Region: ABC_tran_2; pfam12848 74547004443 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 74547004444 ABC transporter; Region: ABC_tran_2; pfam12848 74547004445 CP12 domain; Region: CP12; pfam02672 74547004446 GTPase CgtA; Reviewed; Region: obgE; PRK12299 74547004447 GTP1/OBG; Region: GTP1_OBG; pfam01018 74547004448 Obg GTPase; Region: Obg; cd01898 74547004449 G1 box; other site 74547004450 GTP/Mg2+ binding site [chemical binding]; other site 74547004451 Switch I region; other site 74547004452 G2 box; other site 74547004453 G3 box; other site 74547004454 Switch II region; other site 74547004455 G4 box; other site 74547004456 G5 box; other site 74547004457 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 74547004458 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 74547004459 Walker A/P-loop; other site 74547004460 ATP binding site [chemical binding]; other site 74547004461 Q-loop/lid; other site 74547004462 ABC transporter signature motif; other site 74547004463 Walker B; other site 74547004464 D-loop; other site 74547004465 H-loop/switch region; other site 74547004466 TOBE domain; Region: TOBE_2; pfam08402 74547004467 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 74547004468 MutS domain III; Region: MutS_III; pfam05192 74547004469 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 74547004470 Walker A/P-loop; other site 74547004471 ATP binding site [chemical binding]; other site 74547004472 Q-loop/lid; other site 74547004473 ABC transporter signature motif; other site 74547004474 Walker B; other site 74547004475 D-loop; other site 74547004476 H-loop/switch region; other site 74547004477 Smr domain; Region: Smr; pfam01713 74547004478 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 74547004479 dimer interface [polypeptide binding]; other site 74547004480 active site 74547004481 aspartate-rich active site metal binding site; other site 74547004482 allosteric magnesium binding site [ion binding]; other site 74547004483 Schiff base residues; other site 74547004484 chaperone protein DnaJ; Provisional; Region: PRK14299 74547004485 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 74547004486 HSP70 interaction site [polypeptide binding]; other site 74547004487 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 74547004488 substrate binding site [polypeptide binding]; other site 74547004489 dimer interface [polypeptide binding]; other site 74547004490 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 74547004491 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 74547004492 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 74547004493 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 74547004494 12 probable transmembrane helices predicted by TMHMM2.0 74547004495 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 74547004496 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 74547004497 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 74547004498 1 probable transmembrane helix predicted for by TMHMM2.0 74547004499 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 74547004500 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 74547004501 active site 74547004502 metal binding site [ion binding]; metal-binding site 74547004503 hexamer interface [polypeptide binding]; other site 74547004504 2 probable transmembrane helices predicted by TMHMM2.0 74547004505 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 74547004506 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 74547004507 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 74547004508 carotene isomerase; Region: carot_isom; TIGR02730 74547004509 1 probable transmembrane helix predicted for by TMHMM2.0 74547004510 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 74547004511 1 probable transmembrane helix predicted for by TMHMM2.0 74547004512 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 74547004513 Cytochrome P450; Region: p450; cl12078 74547004514 Protein of unknown function (DUF805); Region: DUF805; pfam05656 74547004515 3 probable transmembrane helices predicted by TMHMM2.0 74547004516 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 74547004517 active site 74547004518 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 74547004519 1 probable transmembrane helix predicted for by TMHMM2.0 74547004520 2 probable transmembrane helices predicted by TMHMM2.0 74547004521 SCP-2 sterol transfer family; Region: SCP2; pfam02036 74547004522 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 74547004523 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 74547004524 HlyD family secretion protein; Region: HlyD_3; pfam13437 74547004525 1 probable transmembrane helix predicted for by TMHMM2.0 74547004526 DevC protein; Region: devC; TIGR01185 74547004527 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 74547004528 FtsX-like permease family; Region: FtsX; pfam02687 74547004529 4 probable transmembrane helices predicted by TMHMM2.0 74547004530 DevC protein; Region: devC; TIGR01185 74547004531 4 probable transmembrane helices predicted by TMHMM2.0 74547004532 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 74547004533 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 74547004534 Walker A/P-loop; other site 74547004535 ATP binding site [chemical binding]; other site 74547004536 Q-loop/lid; other site 74547004537 ABC transporter signature motif; other site 74547004538 Walker B; other site 74547004539 D-loop; other site 74547004540 H-loop/switch region; other site 74547004541 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 74547004542 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 74547004543 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 74547004544 2 probable transmembrane helices predicted by TMHMM2.0 74547004545 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 74547004546 1 probable transmembrane helix predicted for by TMHMM2.0 74547004547 Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862 74547004548 DNA polymerase Ligase (LigD); Region: LigD_N; pfam13298 74547004549 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 74547004550 Walker A/P-loop; other site 74547004551 ATP binding site [chemical binding]; other site 74547004552 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 74547004553 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 74547004554 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 74547004555 Q-loop/lid; other site 74547004556 ABC transporter signature motif; other site 74547004557 Walker B; other site 74547004558 D-loop; other site 74547004559 H-loop/switch region; other site 74547004560 PRC-barrel domain; Region: PRC; pfam05239 74547004561 methionine sulfoxide reductase B; Provisional; Region: PRK00222 74547004562 SelR domain; Region: SelR; pfam01641 74547004563 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 74547004564 Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763 74547004565 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 74547004566 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 74547004567 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 74547004568 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 74547004569 YGGT family; Region: YGGT; pfam02325 74547004570 1 probable transmembrane helix predicted for by TMHMM2.0 74547004571 Photosystem II reaction centre X protein (PsbX); Region: PsbX; cl05887 74547004572 1 probable transmembrane helix predicted for by TMHMM2.0 74547004573 Ycf66 protein N-terminus; Region: Ycf66_N; pfam07444 74547004574 3 probable transmembrane helices predicted by TMHMM2.0 74547004575 bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507 74547004576 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 74547004577 Chlorophyll A-B binding protein; Region: Chloroa_b-bind; cl02879 74547004578 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 74547004579 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 74547004580 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 74547004581 7 probable transmembrane helices predicted by TMHMM2.0 74547004582 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 74547004583 nucleotide binding site/active site [active] 74547004584 HIT family signature motif; other site 74547004585 catalytic residue [active] 74547004586 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 74547004587 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 74547004588 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 74547004589 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 74547004590 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 74547004591 Protein of unknown function (DUF3747); Region: DUF3747; pfam12565 74547004592 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 74547004593 active site 74547004594 catalytic residues [active] 74547004595 metal binding site [ion binding]; metal-binding site 74547004596 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 74547004597 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 74547004598 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 74547004599 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 74547004600 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 74547004601 catalytic residue [active] 74547004602 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 74547004603 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 74547004604 sulfate ABC transporter protein; Validated; Region: ycf16; CHL00131 74547004605 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 74547004606 Walker A/P-loop; other site 74547004607 ATP binding site [chemical binding]; other site 74547004608 Q-loop/lid; other site 74547004609 ABC transporter signature motif; other site 74547004610 Walker B; other site 74547004611 D-loop; other site 74547004612 H-loop/switch region; other site 74547004613 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 74547004614 putative ABC transporter; Region: ycf24; CHL00085 74547004615 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 74547004616 putative DNA binding site [nucleotide binding]; other site 74547004617 iron-sulfur cluster biosynthesis transcriptional regulator SufR; Region: SufR_cyano; TIGR02702 74547004618 putative Zn2+ binding site [ion binding]; other site 74547004619 Transcriptional regulator PadR-like family; Region: PadR; cl17335 74547004620 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 74547004621 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 74547004622 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 74547004623 Carboxy-terminal domain of Formyltransferase and similar domains; Region: FMT_C_like; cl14785 74547004624 nif11-like leader peptide domain; Region: ocin_TIGR03798 74547004625 1 probable transmembrane helix predicted for by TMHMM2.0 74547004626 phosphoglucomutase; Region: PLN02307 74547004627 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 74547004628 active site 74547004629 substrate binding site [chemical binding]; other site 74547004630 metal binding site [ion binding]; metal-binding site 74547004631 2 probable transmembrane helices predicted by TMHMM2.0 74547004632 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 74547004633 14 probable transmembrane helices predicted by TMHMM2.0 74547004634 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 74547004635 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 74547004636 carboxyltransferase (CT) interaction site; other site 74547004637 biotinylation site [posttranslational modification]; other site 74547004638 HlyD family secretion protein; Region: HlyD_3; pfam13437 74547004639 recombination factor protein RarA/unknown domain fusion protein; Reviewed; Region: PRK13341 74547004640 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 74547004641 Walker A motif; other site 74547004642 ATP binding site [chemical binding]; other site 74547004643 Walker B motif; other site 74547004644 arginine finger; other site 74547004645 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 74547004646 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 74547004647 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 74547004648 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 74547004649 catalytic triad [active] 74547004650 Type III pantothenate kinase; Region: Pan_kinase; cl17198 74547004651 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 74547004652 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 74547004653 Active Sites [active] 74547004654 pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169 74547004655 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 74547004656 1 probable transmembrane helix predicted for by TMHMM2.0 74547004657 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 74547004658 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 74547004659 HflX GTPase family; Region: HflX; cd01878 74547004660 G1 box; other site 74547004661 GTP/Mg2+ binding site [chemical binding]; other site 74547004662 Switch I region; other site 74547004663 G2 box; other site 74547004664 G3 box; other site 74547004665 Switch II region; other site 74547004666 G4 box; other site 74547004667 G5 box; other site 74547004668 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 74547004669 transmembrane helices; other site 74547004670 TrkA-C domain; Region: TrkA_C; pfam02080 74547004671 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 74547004672 TrkA-C domain; Region: TrkA_C; pfam02080 74547004673 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 74547004674 9 probable transmembrane helices predicted by TMHMM2.0 74547004675 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 74547004676 Cation transport protein; Region: TrkH; pfam02386 74547004677 11 probable transmembrane helices predicted by TMHMM2.0 74547004678 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 74547004679 TrkA-N domain; Region: TrkA_N; pfam02254 74547004680 TrkA-C domain; Region: TrkA_C; pfam02080 74547004681 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 74547004682 Protein of unknown function (DUF1662); Region: DUF1662; pfam07878 74547004683 1 probable transmembrane helix predicted for by TMHMM2.0 74547004684 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 74547004685 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 74547004686 Walker A/P-loop; other site 74547004687 ATP binding site [chemical binding]; other site 74547004688 Q-loop/lid; other site 74547004689 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 74547004690 ABC transporter; Region: ABC_tran_2; pfam12848 74547004691 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 74547004692 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 74547004693 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 74547004694 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 74547004695 protein binding site [polypeptide binding]; other site 74547004696 Protein of unknown function (DUF2973); Region: DUF2973; pfam11189 74547004697 1 probable transmembrane helix predicted for by TMHMM2.0 74547004698 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 74547004699 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 74547004700 ATP binding site [chemical binding]; other site 74547004701 putative Mg++ binding site [ion binding]; other site 74547004702 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 74547004703 Helicase associated domain (HA2); Region: HA2; pfam04408 74547004704 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 74547004705 light-harvesting-like protein 3; Provisional; Region: PLN00014 74547004706 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 74547004707 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 74547004708 generic binding surface II; other site 74547004709 generic binding surface I; other site 74547004710 Exonuclease VII small subunit; Region: Exonuc_VII_S; pfam02609 74547004711 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 74547004712 2 probable transmembrane helices predicted by TMHMM2.0 74547004713 2 probable transmembrane helices predicted by TMHMM2.0 74547004714 2 probable transmembrane helices predicted by TMHMM2.0 74547004715 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 74547004716 6 probable transmembrane helices predicted by TMHMM2.0 74547004717 Alkaline and neutral invertase; Region: Glyco_hydro_100; pfam12899 74547004718 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 74547004719 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 74547004720 interchain domain interface [polypeptide binding]; other site 74547004721 intrachain domain interface; other site 74547004722 Qi binding site; other site 74547004723 Qo binding site; other site 74547004724 3 probable transmembrane helices predicted by TMHMM2.0 74547004725 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 74547004726 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 74547004727 Qi binding site; other site 74547004728 intrachain domain interface; other site 74547004729 interchain domain interface [polypeptide binding]; other site 74547004730 heme bH binding site [chemical binding]; other site 74547004731 heme bL binding site [chemical binding]; other site 74547004732 Qo binding site; other site 74547004733 5 probable transmembrane helices predicted by TMHMM2.0 74547004734 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 74547004735 C-terminal peptidase (prc); Region: prc; TIGR00225 74547004736 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 74547004737 protein binding site [polypeptide binding]; other site 74547004738 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 74547004739 Catalytic dyad [active] 74547004740 1 probable transmembrane helix predicted for by TMHMM2.0 74547004741 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 74547004742 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 74547004743 Zn2+ binding site [ion binding]; other site 74547004744 Mg2+ binding site [ion binding]; other site 74547004745 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 74547004746 septum site-determining protein MinD; Region: minD_bact; TIGR01968 74547004747 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 74547004748 P-loop; other site 74547004749 ADP binding residues [chemical binding]; other site 74547004750 Switch I; other site 74547004751 Switch II; other site 74547004752 cell division topological specificity factor MinE; Provisional; Region: PRK13988 74547004753 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 74547004754 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 74547004755 DNA binding residues [nucleotide binding] 74547004756 dimerization interface [polypeptide binding]; other site 74547004757 2 probable transmembrane helices predicted by TMHMM2.0 74547004758 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 74547004759 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 74547004760 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 74547004761 DNA protecting protein DprA; Region: dprA; TIGR00732 74547004762 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 74547004763 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 74547004764 active site 74547004765 photosystem II reaction center protein M; Provisional; Region: psbM; PRK04989 74547004766 1 probable transmembrane helix predicted for by TMHMM2.0 74547004767 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 74547004768 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 74547004769 photosystem II chlorophyll-binding protein CP47; Region: PS_II_CP47; TIGR03039 74547004770 5 probable transmembrane helices predicted by TMHMM2.0 74547004771 photosystem II reaction center protein T; Reviewed; Region: psbT; PRK11875 74547004772 1 probable transmembrane helix predicted for by TMHMM2.0 74547004773 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 74547004774 ATP cone domain; Region: ATP-cone; pfam03477 74547004775 30S ribosomal protein S1; Reviewed; Region: PRK07400 74547004776 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 74547004777 RNA binding site [nucleotide binding]; other site 74547004778 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 74547004779 RNA binding site [nucleotide binding]; other site 74547004780 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 74547004781 RNA binding site [nucleotide binding]; other site 74547004782 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 74547004783 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 74547004784 motif II; other site 74547004785 S-adenosylmethionine synthetase; Validated; Region: PRK05250 74547004786 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 74547004787 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 74547004788 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 74547004789 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 74547004790 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 74547004791 nucleotide binding site [chemical binding]; other site 74547004792 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 74547004793 comF family protein; Region: comF; TIGR00201 74547004794 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 74547004795 active site 74547004796 CpeS-like protein; Region: CpeS; pfam09367 74547004797 CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206 74547004798 HEAT repeats; Region: HEAT_2; pfam13646 74547004799 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500 74547004800 protein binding surface [polypeptide binding]; other site 74547004801 HEAT repeats; Region: HEAT_2; pfam13646 74547004802 HEAT repeats; Region: HEAT_2; pfam13646 74547004803 HEAT repeats; Region: HEAT_2; pfam13646 74547004804 Phycobilisome protein; Region: Phycobilisome; cl08227 74547004805 Phycobilisome protein; Region: Phycobilisome; cl08227 74547004806 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 74547004807 heme binding pocket [chemical binding]; other site 74547004808 heme ligand [chemical binding]; other site 74547004809 dihydrobiliverdin:ferredoxin oxidoreductase; Provisional; Region: PRK13247 74547004810 phycoerythrobilin:ferredoxin oxidoreductase; Provisional; Region: PRK13249 74547004811 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 74547004812 Low molecular weight phosphatase family; Region: LMWPc; cd00115 74547004813 active site 74547004814 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 74547004815 bifunctional pantoate ligase/cytidylate kinase; Provisional; Region: PRK13477 74547004816 active site 74547004817 nucleotide binding site [chemical binding]; other site 74547004818 HIGH motif; other site 74547004819 KMSKS motif; other site 74547004820 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 74547004821 CMP-binding site; other site 74547004822 The sites determining sugar specificity; other site 74547004823 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 74547004824 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 74547004825 1 probable transmembrane helix predicted for by TMHMM2.0 74547004826 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 74547004827 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 74547004828 dimerization interface [polypeptide binding]; other site 74547004829 putative ATP binding site [chemical binding]; other site 74547004830 TPR repeat; Region: TPR_11; pfam13414 74547004831 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 74547004832 binding surface 74547004833 TPR motif; other site 74547004834 TPR repeat; Region: TPR_11; pfam13414 74547004835 TPR repeat; Region: TPR_11; pfam13414 74547004836 1 probable transmembrane helix predicted for by TMHMM2.0 74547004837 1 probable transmembrane helix predicted for by TMHMM2.0 74547004838 1 probable transmembrane helix predicted for by TMHMM2.0 74547004839 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 74547004840 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 74547004841 catalytic residues [active] 74547004842 catalytic nucleophile [active] 74547004843 1 probable transmembrane helix predicted for by TMHMM2.0 74547004844 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370 74547004845 conserved hypothetical protein; Region: TIGR03492 74547004846 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 74547004847 catalytic site [active] 74547004848 putative active site [active] 74547004849 putative substrate binding site [chemical binding]; other site 74547004850 Protein of unknown function (DUF3529); Region: DUF3529; pfam12046 74547004851 3 probable transmembrane helices predicted by TMHMM2.0 74547004852 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 74547004853 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 74547004854 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 74547004855 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 74547004856 10 probable transmembrane helices predicted by TMHMM2.0 74547004857 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 74547004858 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 74547004859 dimer interface [polypeptide binding]; other site 74547004860 phosphorylation site [posttranslational modification] 74547004861 PsaD; Region: PsaD; pfam02531 74547004862 anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564 74547004863 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 74547004864 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 74547004865 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 74547004866 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 74547004867 Phosphoenolpyruvate carboxylase; Region: PEPcase; pfam00311 74547004868 recombination protein F; Reviewed; Region: recF; PRK00064 74547004869 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 74547004870 Walker A/P-loop; other site 74547004871 ATP binding site [chemical binding]; other site 74547004872 Q-loop/lid; other site 74547004873 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 74547004874 ABC transporter signature motif; other site 74547004875 Walker B; other site 74547004876 D-loop; other site 74547004877 H-loop/switch region; other site 74547004878 S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK02770 74547004879 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 74547004880 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 74547004881 Ligand Binding Site [chemical binding]; other site 74547004882 hypothetical protein; Validated; Region: PRK07413 74547004883 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; pfam02572 74547004884 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; pfam02572 74547004885 hypothetical protein; Validated; Region: PRK07411 74547004886 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 74547004887 ATP binding site [chemical binding]; other site 74547004888 substrate interface [chemical binding]; other site 74547004889 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 74547004890 active site residue [active] 74547004891 1 probable transmembrane helix predicted for by TMHMM2.0 74547004892 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 74547004893 MPN+ (JAMM) motif; other site 74547004894 Zinc-binding site [ion binding]; other site 74547004895 Domain of unknown function (DUF4308); Region: DUF4308; pfam14159 74547004896 2 probable transmembrane helices predicted by TMHMM2.0 74547004897 Fructosamine kinase; Region: Fructosamin_kin; cl17579 74547004898 Phosphotransferase enzyme family; Region: APH; pfam01636 74547004899 C-3',4' desaturase CrtD; Region: desat_CrtD; TIGR02733 74547004900 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 74547004901 arogenate dehydrogenase; Reviewed; Region: PRK07417 74547004902 prephenate dehydrogenase; Validated; Region: PRK08507 74547004903 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 74547004904 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 74547004905 Protein of unknown function (DUF2839); Region: DUF2839; pfam10999 74547004906 1 probable transmembrane helix predicted for by TMHMM2.0 74547004907 recombinase A; Provisional; Region: recA; PRK09354 74547004908 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 74547004909 hexamer interface [polypeptide binding]; other site 74547004910 Walker A motif; other site 74547004911 ATP binding site [chemical binding]; other site 74547004912 Walker B motif; other site 74547004913 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 74547004914 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 74547004915 motif II; other site 74547004916 ncharacterized protein conserved in bacteria [Function unknown]; Region: SpoIIIAA; COG3854 74547004917 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 74547004918 Walker A motif; other site 74547004919 ATP binding site [chemical binding]; other site 74547004920 Walker B motif; other site 74547004921 R3H domain of a group of proteins with unknown function, who also contain a AAA-ATPase (AAA) domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is...; Region: R3H_AAA; cd02645 74547004922 RxxxH motif; other site 74547004923 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 74547004924 Iron-Sulfur binding protein C terminal; Region: LdpA_C; pfam12617 74547004925 NADH-quinone oxidoreductase cyanobacterial subunit N; Region: NdhN; pfam11909 74547004926 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 74547004927 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 74547004928 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 74547004929 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 74547004930 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 74547004931 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 74547004932 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 74547004933 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 74547004934 putative translocon binding site; other site 74547004935 protein-rRNA interface [nucleotide binding]; other site 74547004936 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 74547004937 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 74547004938 G-X-X-G motif; other site 74547004939 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 74547004940 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 74547004941 23S rRNA interface [nucleotide binding]; other site 74547004942 5S rRNA interface [nucleotide binding]; other site 74547004943 putative antibiotic binding site [chemical binding]; other site 74547004944 L25 interface [polypeptide binding]; other site 74547004945 L27 interface [polypeptide binding]; other site 74547004946 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 74547004947 23S rRNA interface [nucleotide binding]; other site 74547004948 putative translocon interaction site; other site 74547004949 signal recognition particle (SRP54) interaction site; other site 74547004950 L23 interface [polypeptide binding]; other site 74547004951 trigger factor interaction site; other site 74547004952 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 74547004953 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 74547004954 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 74547004955 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 74547004956 RNA binding site [nucleotide binding]; other site 74547004957 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 74547004958 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 74547004959 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 74547004960 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 74547004961 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 74547004962 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 74547004963 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 74547004964 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 74547004965 5S rRNA interface [nucleotide binding]; other site 74547004966 23S rRNA interface [nucleotide binding]; other site 74547004967 L5 interface [polypeptide binding]; other site 74547004968 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 74547004969 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 74547004970 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 74547004971 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 74547004972 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 74547004973 SecY translocase; Region: SecY; pfam00344 74547004974 10 probable transmembrane helices predicted by TMHMM2.0 74547004975 adenylate kinase; Provisional; Region: PRK14531 74547004976 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 74547004977 AMP-binding site [chemical binding]; other site 74547004978 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 74547004979 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 74547004980 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 74547004981 30S ribosomal protein S13; Region: bact_S13; TIGR03631 74547004982 30S ribosomal protein S11; Validated; Region: PRK05309 74547004983 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 74547004984 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 74547004985 alphaNTD homodimer interface [polypeptide binding]; other site 74547004986 alphaNTD - beta interaction site [polypeptide binding]; other site 74547004987 alphaNTD - beta' interaction site [polypeptide binding]; other site 74547004988 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 74547004989 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 74547004990 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 74547004991 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 74547004992 dimerization interface 3.5A [polypeptide binding]; other site 74547004993 active site 74547004994 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 74547004995 23S rRNA interface [nucleotide binding]; other site 74547004996 L3 interface [polypeptide binding]; other site 74547004997 ribosomal protein S9; Region: rps9; CHL00079 74547004998 ribosomal protein L31; Validated; Region: rpl31; CHL00136 74547004999 peptide chain release factor 1; Validated; Region: prfA; PRK00591 74547005000 This domain is found in peptide chain release factors; Region: PCRF; smart00937 74547005001 RF-1 domain; Region: RF-1; pfam00472 74547005002 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 74547005003 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 74547005004 active site 74547005005 alanine racemase; Reviewed; Region: alr; PRK00053 74547005006 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 74547005007 active site 74547005008 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 74547005009 dimer interface [polypeptide binding]; other site 74547005010 substrate binding site [chemical binding]; other site 74547005011 catalytic residues [active] 74547005012 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 74547005013 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 74547005014 NlpC/P60 family; Region: NLPC_P60; pfam00877 74547005015 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 74547005016 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 74547005017 Ligand binding site; other site 74547005018 Putative Catalytic site; other site 74547005019 DXD motif; other site 74547005020 2 probable transmembrane helices predicted by TMHMM2.0 74547005021 photosystem I reaction center subunit VIII; Reviewed; Region: psaI; PRK11877 74547005022 1 probable transmembrane helix predicted for by TMHMM2.0 74547005023 photosystem I reaction center protein subunit XI; Provisional; Region: PRK00704 74547005024 2 probable transmembrane helices predicted by TMHMM2.0 74547005025 photosystem I P700 chlorophyll a apoprotein A2; Provisional; Region: psaB; PRK13199 74547005026 11 probable transmembrane helices predicted by TMHMM2.0 74547005027 photosystem I P700 chlorophyll a apoprotein A1; Provisional; Region: psaA; PRK13200 74547005028 9 probable transmembrane helices predicted by TMHMM2.0 74547005029 Potato leaf roll virus readthrough protein; Region: PLRV_ORF5; pfam01690 74547005030 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 74547005031 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 74547005032 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 74547005033 active site 74547005034 SAM binding site [chemical binding]; other site 74547005035 homodimer interface [polypeptide binding]; other site 74547005036 lycopene cyclase family protein; Region: carotene-cycl; TIGR01790 74547005037 1 probable transmembrane helix predicted for by TMHMM2.0 74547005038 lipoyl synthase; Provisional; Region: PRK05481 74547005039 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 74547005040 FeS/SAM binding site; other site 74547005041 YCII-related domain; Region: YCII; cl00999 74547005042 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 74547005043 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 74547005044 active site 74547005045 dimer interface [polypeptide binding]; other site 74547005046 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 74547005047 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 74547005048 active site 74547005049 FMN binding site [chemical binding]; other site 74547005050 substrate binding site [chemical binding]; other site 74547005051 3Fe-4S cluster binding site [ion binding]; other site 74547005052 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 74547005053 domain interface; other site 74547005054 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 74547005055 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 74547005056 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 74547005057 S17 interaction site [polypeptide binding]; other site 74547005058 S8 interaction site; other site 74547005059 16S rRNA interaction site [nucleotide binding]; other site 74547005060 streptomycin interaction site [chemical binding]; other site 74547005061 23S rRNA interaction site [nucleotide binding]; other site 74547005062 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 74547005063 30S ribosomal protein S7; Validated; Region: PRK05302 74547005064 elongation factor G; Reviewed; Region: PRK00007 74547005065 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 74547005066 G1 box; other site 74547005067 putative GEF interaction site [polypeptide binding]; other site 74547005068 GTP/Mg2+ binding site [chemical binding]; other site 74547005069 Switch I region; other site 74547005070 G2 box; other site 74547005071 G3 box; other site 74547005072 Switch II region; other site 74547005073 G4 box; other site 74547005074 G5 box; other site 74547005075 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 74547005076 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 74547005077 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 74547005078 elongation factor Tu; Reviewed; Region: PRK00049 74547005079 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 74547005080 G1 box; other site 74547005081 GEF interaction site [polypeptide binding]; other site 74547005082 GTP/Mg2+ binding site [chemical binding]; other site 74547005083 Switch I region; other site 74547005084 G2 box; other site 74547005085 G3 box; other site 74547005086 Switch II region; other site 74547005087 G4 box; other site 74547005088 G5 box; other site 74547005089 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 74547005090 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 74547005091 Antibiotic Binding Site [chemical binding]; other site 74547005092 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 74547005093 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 74547005094 tocopherol O-methyltransferase; Region: PLN02244 74547005095 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 74547005096 S-adenosylmethionine binding site [chemical binding]; other site 74547005097 prephenate dehydratase; Provisional; Region: PRK11898 74547005098 Prephenate dehydratase; Region: PDT; pfam00800 74547005099 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 74547005100 putative L-Phe binding site [chemical binding]; other site 74547005101 Protein of unknown function (DUF1997); Region: DUF1997; pfam09366 74547005102 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 74547005103 RNA/DNA hybrid binding site [nucleotide binding]; other site 74547005104 active site 74547005105 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 74547005106 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 74547005107 homodimer interface [polypeptide binding]; other site 74547005108 oligonucleotide binding site [chemical binding]; other site 74547005109 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 74547005110 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 74547005111 B12 binding site [chemical binding]; other site 74547005112 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 74547005113 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105 74547005114 L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590 74547005115 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 74547005116 pyridoxal 5'-phosphate binding site [chemical binding]; other site 74547005117 homodimer interface [polypeptide binding]; other site 74547005118 catalytic residue [active] 74547005119 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 74547005120 7 probable transmembrane helices predicted by TMHMM2.0 74547005121 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 74547005122 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 74547005123 FeS/SAM binding site; other site 74547005124 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 74547005125 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 74547005126 Tetramer interface [polypeptide binding]; other site 74547005127 active site 74547005128 FMN-binding site [chemical binding]; other site 74547005129 3 probable transmembrane helices predicted by TMHMM2.0 74547005130 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 74547005131 active site 74547005132 intersubunit interface [polypeptide binding]; other site 74547005133 catalytic residue [active] 74547005134 FtsH Extracellular; Region: FtsH_ext; pfam06480 74547005135 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 74547005136 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 74547005137 Walker A motif; other site 74547005138 ATP binding site [chemical binding]; other site 74547005139 Walker B motif; other site 74547005140 arginine finger; other site 74547005141 Peptidase family M41; Region: Peptidase_M41; pfam01434 74547005142 1 probable transmembrane helix predicted for by TMHMM2.0 74547005143 ATP sulphurylase; Region: sopT; TIGR00339 74547005144 ATP-sulfurylase; Region: ATPS; cd00517 74547005145 active site 74547005146 HXXH motif; other site 74547005147 flexible loop; other site 74547005148 Manganese-stabilising protein / photosystem II polypeptide; Region: MSP; cl03326 74547005149 1 probable transmembrane helix predicted for by TMHMM2.0 74547005150 ribonucleoside-diphosphate reductase subunit alpha; Provisional; Region: nrdA; PHA02572 74547005151 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 74547005152 Flavoprotein; Region: Flavoprotein; pfam02441 74547005153 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 74547005154 1 probable transmembrane helix predicted for by TMHMM2.0 74547005155 Protein of unknown function (DUF2555); Region: DUF2555; pfam10742 74547005156 1 probable transmembrane helix predicted for by TMHMM2.0 74547005157 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 74547005158 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 74547005159 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 74547005160 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 74547005161 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 74547005162 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 74547005163 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 74547005164 active site 74547005165 DNA binding site [nucleotide binding] 74547005166 TPR repeat; Region: TPR_11; pfam13414 74547005167 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 74547005168 binding surface 74547005169 TPR motif; other site 74547005170 TPR repeat; Region: TPR_11; pfam13414 74547005171 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 74547005172 binding surface 74547005173 TPR motif; other site 74547005174 Tetratricopeptide repeat; Region: TPR_16; pfam13432 74547005175 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 74547005176 binding surface 74547005177 Tetratricopeptide repeat; Region: TPR_12; pfam13424 74547005178 TPR motif; other site 74547005179 Tetratricopeptide repeat; Region: TPR_12; pfam13424 74547005180 TPR repeat; Region: TPR_11; pfam13414 74547005181 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 74547005182 binding surface 74547005183 TPR motif; other site 74547005184 TPR repeat; Region: TPR_11; pfam13414 74547005185 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 74547005186 binding surface 74547005187 TPR repeat; Region: TPR_11; pfam13414 74547005188 TPR motif; other site 74547005189 TPR repeat; Region: TPR_11; pfam13414 74547005190 TPR repeat; Region: TPR_11; pfam13414 74547005191 Tetratricopeptide repeat; Region: TPR_17; pfam13431 74547005192 Tetratricopeptide repeat; Region: TPR_16; pfam13432 74547005193 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 74547005194 binding surface 74547005195 TPR motif; other site 74547005196 Tetratricopeptide repeat; Region: TPR_12; pfam13424 74547005197 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 74547005198 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 74547005199 binding surface 74547005200 TPR motif; other site 74547005201 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 74547005202 binding surface 74547005203 TPR motif; other site 74547005204 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 74547005205 binding surface 74547005206 TPR motif; other site 74547005207 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 74547005208 Protein of unknown function, DUF481; Region: DUF481; cl01213 74547005209 Creatinine amidohydrolase; Region: Creatininase; pfam02633 74547005210 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 74547005211 Beta-carotene hydroxylase (CrtR), the carotenoid zeaxanthin biosynthetic enzyme catalyzes the addition of hydroxyl groups to the beta-ionone rings of beta-carotene to form zeaxanthin and is found in bacteria and red algae. Carotenoids are important...; Region: CrtR_beta-carotene-hydroxylase; cd03514 74547005212 Fatty acid desaturase; Region: FA_desaturase; pfam00487 74547005213 putative di-iron ligands [ion binding]; other site 74547005214 5 probable transmembrane helices predicted by TMHMM2.0 74547005215 2 probable transmembrane helices predicted by TMHMM2.0 74547005216 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 74547005217 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 74547005218 active site 74547005219 HIGH motif; other site 74547005220 nucleotide binding site [chemical binding]; other site 74547005221 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 74547005222 active site 74547005223 KMSKS motif; other site 74547005224 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 74547005225 tRNA binding surface [nucleotide binding]; other site 74547005226 anticodon binding site; other site 74547005227 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 74547005228 Protein of unknown function (DUF3177); Region: DUF3177; pfam11375 74547005229 5 probable transmembrane helices predicted by TMHMM2.0 74547005230 FIST N domain; Region: FIST; smart00897 74547005231 FIST C domain; Region: FIST_C; pfam10442 74547005232 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 74547005233 S-adenosylmethionine binding site [chemical binding]; other site 74547005234 putative bicarbonate transporter, IctB family; Region: 2A73; TIGR00947 74547005235 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 74547005236 7 probable transmembrane helices predicted by TMHMM2.0 74547005237 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 74547005238 nucleotide binding site [chemical binding]; other site 74547005239 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14317 74547005240 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 74547005241 active site 74547005242 substrate binding site [chemical binding]; other site 74547005243 metal binding site [ion binding]; metal-binding site 74547005244 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 74547005245 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 74547005246 N-acetyl-D-glucosamine binding site [chemical binding]; other site 74547005247 catalytic residue [active] 74547005248 4 probable transmembrane helices predicted by TMHMM2.0 74547005249 TRX-like protein A (TxlA) family; TxlA was originally isolated from the cyanobacterium Synechococcus. It is found only in oxygenic photosynthetic organisms. TRX is a small enzyme that participate in redox reactions, via the reversible oxidation of an...; Region: TxlA; cd02950 74547005250 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 74547005251 catalytic residues [active] 74547005252 1 probable transmembrane helix predicted for by TMHMM2.0 74547005253 4 probable transmembrane helices predicted by TMHMM2.0 74547005254 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 74547005255 trimer interface [polypeptide binding]; other site 74547005256 active site 74547005257 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; cl17276 74547005258 ribonuclease PH; Reviewed; Region: rph; PRK00173 74547005259 Ribonuclease PH; Region: RNase_PH_bact; cd11362 74547005260 hexamer interface [polypeptide binding]; other site 74547005261 active site 74547005262 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 74547005263 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 74547005264 ligand binding site [chemical binding]; other site 74547005265 flexible hinge region; other site 74547005266 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 74547005267 putative switch regulator; other site 74547005268 non-specific DNA interactions [nucleotide binding]; other site 74547005269 DNA binding site [nucleotide binding] 74547005270 sequence specific DNA binding site [nucleotide binding]; other site 74547005271 putative cAMP binding site [chemical binding]; other site 74547005272 Protein of unknown function (DUF3084); Region: DUF3084; pfam11283 74547005273 Uncharacterized protein conserved in bacteria with the myosin-like domain [Function unknown]; Region: COG4372 74547005274 2 probable transmembrane helices predicted by TMHMM2.0 74547005275 Uncharacterized protein family (UPF0081); Region: UPF0081; cl17278 74547005276 Protein of unknown function (DUF3146); Region: DUF3146; pfam11344 74547005277 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 74547005278 putative active site [active] 74547005279 catalytic residue [active] 74547005280 twin arginine translocase protein A; Provisional; Region: tatA; PRK14857 74547005281 1 probable transmembrane helix predicted for by TMHMM2.0 74547005282 photosystem II reaction center protein H; Provisional; Region: psbH; PRK02624 74547005283 photosystem II reaction center protein N; Provisional; Region: psbN; PRK13183 74547005284 1 probable transmembrane helix predicted for by TMHMM2.0 74547005285 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 74547005286 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 74547005287 active site 74547005288 catalytic site [active] 74547005289 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; pfam09261 74547005290 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 74547005291 photosystem II reaction center I protein I; Provisional; Region: psbI; PRK02655 74547005292 Protein of unknown function (DUF3769); Region: DUF3769; pfam12600 74547005293 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 74547005294 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 74547005295 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 74547005296 1 probable transmembrane helix predicted for by TMHMM2.0 74547005297 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 74547005298 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 74547005299 substrate binding site [chemical binding]; other site 74547005300 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 74547005301 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 74547005302 substrate binding site [chemical binding]; other site 74547005303 ligand binding site [chemical binding]; other site 74547005304 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 74547005305 competence damage-inducible protein A; Provisional; Region: PRK00549 74547005306 putative MPT binding site; other site 74547005307 Competence-damaged protein; Region: CinA; pfam02464 74547005308 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 74547005309 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 74547005310 Mg++ binding site [ion binding]; other site 74547005311 putative catalytic motif [active] 74547005312 substrate binding site [chemical binding]; other site 74547005313 10 probable transmembrane helices predicted by TMHMM2.0 74547005314 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 74547005315 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 74547005316 dimer interface [polypeptide binding]; other site 74547005317 active site 74547005318 glycine-pyridoxal phosphate binding site [chemical binding]; other site 74547005319 folate binding site [chemical binding]; other site 74547005320 2TM domain; Region: 2TM; pfam13239 74547005321 2 probable transmembrane helices predicted by TMHMM2.0 74547005322 Protein of unknown function (DUF3181); Region: DUF3181; pfam11378 74547005323 transferase, transferring glycosyl groups; Region: PLN02275 74547005324 integral membrane protein MviN; Region: mviN; TIGR01695 74547005325 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 74547005326 12 probable transmembrane helices predicted by TMHMM2.0 74547005327 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 74547005328 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 74547005329 12 probable transmembrane helices predicted by TMHMM2.0 74547005330 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Provisional; Region: PRK13371 74547005331 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 74547005332 Protein of unknown function (DUF1997); Region: DUF1997; pfam09366 74547005333 DoxX; Region: DoxX; pfam07681 74547005334 3 probable transmembrane helices predicted by TMHMM2.0 74547005335 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 74547005336 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 74547005337 purine monophosphate binding site [chemical binding]; other site 74547005338 dimer interface [polypeptide binding]; other site 74547005339 putative catalytic residues [active] 74547005340 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 74547005341 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 74547005342 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 74547005343 putative hydrolase; Provisional; Region: PRK11460 74547005344 Protein of unknown function (DUF3155); Region: DUF3155; pfam11352 74547005345 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 74547005346 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 74547005347 dimer interface [polypeptide binding]; other site 74547005348 phosphorylation site [posttranslational modification] 74547005349 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 74547005350 ATP binding site [chemical binding]; other site 74547005351 Mg2+ binding site [ion binding]; other site 74547005352 G-X-G motif; other site 74547005353 cobalamin synthase; Reviewed; Region: cobS; PRK00235 74547005354 8 probable transmembrane helices predicted by TMHMM2.0 74547005355 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 74547005356 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 74547005357 photosystem II reaction center protein K; Provisional; Region: psbK; PRK02553 74547005358 1 probable transmembrane helix predicted for by TMHMM2.0 74547005359 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 74547005360 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 74547005361 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 74547005362 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 74547005363 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 74547005364 Domain of unknown function DUF21; Region: DUF21; pfam01595 74547005365 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 74547005366 Transporter associated domain; Region: CorC_HlyC; smart01091 74547005367 4 probable transmembrane helices predicted by TMHMM2.0 74547005368 1 probable transmembrane helix predicted for by TMHMM2.0 74547005369 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 74547005370 active site 74547005371 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 74547005372 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 74547005373 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 74547005374 RecB family nuclease, putative, TM0106 family; Region: TIGR03491 74547005375 RNase_H superfamily; Region: RNase_H_2; pfam13482 74547005376 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 74547005377 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 74547005378 active site 74547005379 substrate binding site [chemical binding]; other site 74547005380 metal binding site [ion binding]; metal-binding site 74547005381 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 74547005382 active site 74547005383 dimerization interface [polypeptide binding]; other site 74547005384 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 74547005385 12 probable transmembrane helices predicted by TMHMM2.0 74547005386 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 74547005388 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 74547005389 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 74547005390 imidazoleglycerol-phosphate dehydratase; Region: PLN02800 74547005391 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 74547005392 putative active site pocket [active] 74547005393 4-fold oligomerization interface [polypeptide binding]; other site 74547005394 metal binding residues [ion binding]; metal-binding site 74547005395 3-fold/trimer interface [polypeptide binding]; other site 74547005396 enoyl-(acyl carrier protein) reductase; Validated; Region: PRK07370 74547005397 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 74547005398 NAD binding site [chemical binding]; other site 74547005399 homotetramer interface [polypeptide binding]; other site 74547005400 homodimer interface [polypeptide binding]; other site 74547005401 substrate binding site [chemical binding]; other site 74547005402 active site 74547005403 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 74547005404 putative catalytic residue [active] 74547005405 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 74547005406 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 74547005407 inhibitor-cofactor binding pocket; inhibition site 74547005408 pyridoxal 5'-phosphate binding site [chemical binding]; other site 74547005409 catalytic residue [active] 74547005410 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 74547005411 dimer interface [polypeptide binding]; other site 74547005412 ADP-ribose binding site [chemical binding]; other site 74547005413 active site 74547005414 nudix motif; other site 74547005415 metal binding site [ion binding]; metal-binding site 74547005416 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 74547005417 catalytic center binding site [active] 74547005418 ATP binding site [chemical binding]; other site 74547005419 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 74547005420 magnesium chelatase ATPase subunit D; Region: BchD-ChlD; TIGR02031 74547005421 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 74547005422 metal ion-dependent adhesion site (MIDAS); other site 74547005423 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 74547005424 mce related protein; Region: MCE; pfam02470 74547005425 1 probable transmembrane helix predicted for by TMHMM2.0 74547005426 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 74547005427 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 74547005428 Walker A/P-loop; other site 74547005429 ATP binding site [chemical binding]; other site 74547005430 Q-loop/lid; other site 74547005431 ABC transporter signature motif; other site 74547005432 Walker B; other site 74547005433 D-loop; other site 74547005434 H-loop/switch region; other site 74547005435 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 74547005436 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 74547005437 phosphate binding site [ion binding]; other site 74547005438 putative substrate binding pocket [chemical binding]; other site 74547005439 dimer interface [polypeptide binding]; other site 74547005440 2 probable transmembrane helices predicted by TMHMM2.0 74547005441 NADH dehydrogenase subunit J; Provisional; Region: PRK12494 74547005442 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 74547005443 NADH dehydrogenase subunit K; Region: ndhK; CHL00023 74547005444 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 74547005445 3 probable transmembrane helices predicted by TMHMM2.0 74547005446 Rubredoxin [Energy production and conversion]; Region: COG1773 74547005447 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 74547005448 iron binding site [ion binding]; other site 74547005449 1 probable transmembrane helix predicted for by TMHMM2.0 74547005450 Ycf48-like protein; Provisional; Region: PRK13684 74547005451 1 probable transmembrane helix predicted for by TMHMM2.0 74547005452 cytochrome b559 subunit alpha; Provisional; Region: psbE; PRK02557 74547005453 Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits; Region: Cytochrom_B559; pfam00283 74547005454 Lumenal portion of Cytochrome b559, alpha (gene psbE) subunit; Region: Cytochrom_B559a; pfam00284 74547005455 1 probable transmembrane helix predicted for by TMHMM2.0 74547005456 cytochrome b559 subunit beta; Provisional; Region: psbF; PRK02561 74547005457 1 probable transmembrane helix predicted for by TMHMM2.0 74547005458 1 probable transmembrane helix predicted for by TMHMM2.0 74547005459 photosystem II reaction center protein J; Provisional; Region: PRK02565 74547005460 1 probable transmembrane helix predicted for by TMHMM2.0 74547005461 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 74547005462 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 74547005463 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 74547005464 short chain dehydrogenase; Validated; Region: PRK08324 74547005465 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 74547005466 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 74547005467 NAD(P) binding site [chemical binding]; other site 74547005468 active site 74547005469 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 74547005470 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 74547005471 putative NAD(P) binding site [chemical binding]; other site 74547005472 active site 74547005473 putative substrate binding site [chemical binding]; other site 74547005474 probable UDP-glucose 6-dehydrogenase; Region: PLN02353 74547005475 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 74547005476 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 74547005477 histidyl-tRNA synthetase; Region: hisS; TIGR00442 74547005478 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 74547005479 dimer interface [polypeptide binding]; other site 74547005480 motif 1; other site 74547005481 active site 74547005482 motif 2; other site 74547005483 motif 3; other site 74547005484 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 74547005485 anticodon binding site; other site 74547005486 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 74547005487 UDP-glucose 4-epimerase; Region: PLN02240 74547005488 NAD binding site [chemical binding]; other site 74547005489 homodimer interface [polypeptide binding]; other site 74547005490 active site 74547005491 substrate binding site [chemical binding]; other site 74547005492 Bacterial sugar transferase; Region: Bac_transf; pfam02397 74547005493 5 probable transmembrane helices predicted by TMHMM2.0 74547005494 pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169 74547005495 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 74547005496 dimerization interface [polypeptide binding]; other site 74547005497 putative ATP binding site [chemical binding]; other site 74547005498 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 74547005499 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 74547005500 active site 74547005501 NTP binding site [chemical binding]; other site 74547005502 metal binding triad [ion binding]; metal-binding site 74547005503 KpsF/GutQ family protein; Region: kpsF; TIGR00393 74547005504 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 74547005505 putative active site [active] 74547005506 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 74547005507 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 74547005508 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 74547005509 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 74547005510 Ligand binding site; other site 74547005511 oligomer interface; other site 74547005512 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 74547005513 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 74547005514 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 74547005515 Part of AAA domain; Region: AAA_19; pfam13245 74547005516 Family description; Region: UvrD_C_2; pfam13538 74547005517 7 probable transmembrane helices predicted by TMHMM2.0 74547005518 12 probable transmembrane helices predicted by TMHMM2.0 74547005519 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 74547005520 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 74547005521 putative ADP-binding pocket [chemical binding]; other site 74547005522 TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305 74547005523 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK12457 74547005524 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 74547005525 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_7; cd05844 74547005526 putative ADP-binding pocket [chemical binding]; other site 74547005527 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 74547005528 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 74547005529 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 74547005530 putative ADP-binding pocket [chemical binding]; other site 74547005531 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 74547005532 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 74547005533 putative homodimer interface [polypeptide binding]; other site 74547005534 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 74547005535 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 74547005536 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 74547005537 Walker A/P-loop; other site 74547005538 ATP binding site [chemical binding]; other site 74547005539 Q-loop/lid; other site 74547005540 ABC transporter signature motif; other site 74547005541 Walker B; other site 74547005542 D-loop; other site 74547005543 H-loop/switch region; other site 74547005544 5 probable transmembrane helices predicted by TMHMM2.0 74547005545 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 74547005546 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 74547005547 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 74547005548 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl17299 74547005549 heme ligand [chemical binding]; other site 74547005550 Predicted membrane protein [Function unknown]; Region: COG2246 74547005551 GtrA-like protein; Region: GtrA; pfam04138 74547005552 uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_3; cd10807 74547005553 putative active site [active] 74547005554 YdjC motif; other site 74547005555 Mg binding site [ion binding]; other site 74547005556 putative homodimer interface [polypeptide binding]; other site 74547005557 4 probable transmembrane helices predicted by TMHMM2.0 74547005558 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 74547005559 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 74547005560 Ligand binding site; other site 74547005561 Putative Catalytic site; other site 74547005562 DXD motif; other site 74547005563 2 probable transmembrane helices predicted by TMHMM2.0 74547005564 isocitrate dehydrogenase; Validated; Region: PRK07362 74547005565 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 74547005566 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 74547005567 Cysteine-rich domain; Region: CCG; pfam02754 74547005568 Cysteine-rich domain; Region: CCG; pfam02754 74547005569 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 74547005570 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 74547005571 FAD binding domain; Region: FAD_binding_4; pfam01565 74547005572 Aldose 1-epimerase, similar to Synechocystis Slr1438; Region: Aldose_epim_Slr1438; cd09025 74547005573 active site 74547005574 catalytic residues [active] 74547005575 hydrolase, alpha/beta fold family protein; Region: PLN02824 74547005576 Partial alpha/beta-hydrolase lipase region; Region: Abhydro_lipase; pfam04083 74547005577 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 74547005578 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 74547005579 11 probable transmembrane helices predicted by TMHMM2.0 74547005580 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 74547005581 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 74547005582 homodimer interface [polypeptide binding]; other site 74547005583 active site pocket [active] 74547005584 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 74547005585 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 74547005586 dimerization interface [polypeptide binding]; other site 74547005587 active site 74547005588 metal binding site [ion binding]; metal-binding site 74547005589 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 74547005590 dsRNA binding site [nucleotide binding]; other site 74547005591 Protein of unknown function (DUF3252); Region: DUF3252; pfam11623 74547005592 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 74547005593 RimM N-terminal domain; Region: RimM; pfam01782 74547005594 PRC-barrel domain; Region: PRC; pfam05239 74547005595 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 74547005596 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 74547005597 Substrate binding site; other site 74547005598 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 74547005599 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 74547005600 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 74547005601 glutaminase active site [active] 74547005602 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 74547005603 dimer interface [polypeptide binding]; other site 74547005604 active site 74547005605 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 74547005606 dimer interface [polypeptide binding]; other site 74547005607 active site 74547005608 photosystem I subunit VII; Region: psaC; CHL00065 74547005609 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 74547005610 acyl carrier protein; Provisional; Region: acpP; PRK00982 74547005611 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 74547005612 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 74547005613 dimer interface [polypeptide binding]; other site 74547005614 active site 74547005615 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 74547005616 transketolase; Region: PLN02790 74547005617 TPP-binding site [chemical binding]; other site 74547005618 dimer interface [polypeptide binding]; other site 74547005619 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 74547005620 PYR/PP interface [polypeptide binding]; other site 74547005621 dimer interface [polypeptide binding]; other site 74547005622 TPP binding site [chemical binding]; other site 74547005623 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 74547005624 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 74547005625 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 74547005626 NAD binding site [chemical binding]; other site 74547005627 putative substrate binding site 2 [chemical binding]; other site 74547005628 putative substrate binding site 1 [chemical binding]; other site 74547005629 active site 74547005630 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 74547005631 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 74547005632 Ligand binding site; other site 74547005633 Putative Catalytic site; other site 74547005634 DXD motif; other site 74547005635 GtrA-like protein; Region: GtrA; pfam04138 74547005636 4 probable transmembrane helices predicted by TMHMM2.0 74547005637 Protein of unknown function (DUF3571); Region: DUF3571; pfam12095 74547005638 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 74547005639 maleylacetoacetate isomerase; Region: maiA; TIGR01262 74547005640 C-terminal domain interface [polypeptide binding]; other site 74547005641 GSH binding site (G-site) [chemical binding]; other site 74547005642 dimer interface [polypeptide binding]; other site 74547005643 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 74547005644 N-terminal domain interface [polypeptide binding]; other site 74547005645 Protein of unknown function (DUF751); Region: DUF751; pfam05421 74547005646 2 probable transmembrane helices predicted by TMHMM2.0 74547005647 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 74547005648 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 74547005649 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 74547005650 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 74547005651 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 74547005652 putative metal binding site; other site 74547005653 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 74547005654 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 74547005655 binding surface 74547005656 TPR motif; other site 74547005657 TPR repeat; Region: TPR_11; pfam13414 74547005658 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 74547005659 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 74547005660 active site 74547005661 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 74547005662 putative hydrophobic ligand binding site [chemical binding]; other site 74547005663 9,9'-di-cis-zeta-carotene desaturase; Region: zeta_caro_desat; TIGR02732 74547005664 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 74547005665 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 74547005666 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 74547005667 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370 74547005668 conserved hypothetical protein; Region: TIGR03492 74547005669 2 probable transmembrane helices predicted by TMHMM2.0 74547005670 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 74547005671 TIGR01777 family protein; Region: yfcH 74547005672 putative NAD(P) binding site [chemical binding]; other site 74547005673 putative active site [active] 74547005674 potassium/proton antiporter; Reviewed; Region: PRK05326 74547005675 11 probable transmembrane helices predicted by TMHMM2.0 74547005676 Cyanobacterial and plant NDH-1 subunit O; Region: NdhO; pfam11910 74547005677 11 probable transmembrane helices predicted by TMHMM2.0 74547005678 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 74547005679 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 74547005680 HSP70 interaction site [polypeptide binding]; other site 74547005681 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 74547005682 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 74547005683 dimer interface [polypeptide binding]; other site 74547005684 pyridoxal 5'-phosphate binding site [chemical binding]; other site 74547005685 catalytic residue [active] 74547005686 S-layer homology domain; Region: SLH; pfam00395 74547005687 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 74547005688 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 74547005689 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 74547005690 10 probable transmembrane helices predicted by TMHMM2.0 74547005691 1 probable transmembrane helix predicted for by TMHMM2.0 74547005692 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 74547005693 11 probable transmembrane helices predicted by TMHMM2.0 74547005694 Predicted membrane protein [Function unknown]; Region: COG3463 74547005695 Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852 74547005696 8 probable transmembrane helices predicted by TMHMM2.0 74547005697 Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852 74547005698 Predicted membrane protein [Function unknown]; Region: COG3463 74547005699 6 probable transmembrane helices predicted by TMHMM2.0 74547005700 8 probable transmembrane helices predicted by TMHMM2.0 74547005701 hypothetical protein; Provisional; Region: PRK13683 74547005702 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 74547005703 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 74547005704 Walker A/P-loop; other site 74547005705 ATP binding site [chemical binding]; other site 74547005706 Q-loop/lid; other site 74547005707 ABC transporter signature motif; other site 74547005708 Walker B; other site 74547005709 D-loop; other site 74547005710 H-loop/switch region; other site 74547005711 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 74547005712 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 74547005713 active site 74547005714 phosphorylation site [posttranslational modification] 74547005715 intermolecular recognition site; other site 74547005716 dimerization interface [polypeptide binding]; other site 74547005717 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 74547005718 DNA binding site [nucleotide binding] 74547005719 DNA polymerase III subunit delta'; Validated; Region: PRK07399 74547005720 DNA polymerase III subunit delta'; Validated; Region: PRK08485 74547005721 thymidylate kinase; Validated; Region: tmk; PRK00698 74547005722 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 74547005723 TMP-binding site; other site 74547005724 ATP-binding site [chemical binding]; other site 74547005725 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 74547005726 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 74547005727 metal-binding site [ion binding] 74547005728 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 74547005729 8 probable transmembrane helices predicted by TMHMM2.0 74547005730 photosystem I assembly protein Ycf3; Provisional; Region: PRK02603 74547005731 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 74547005732 binding surface 74547005733 TPR motif; other site 74547005734 DNA repair protein RadA; Provisional; Region: PRK11823 74547005735 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 74547005736 Walker A motif; other site 74547005737 ATP binding site [chemical binding]; other site 74547005738 Walker B motif; other site 74547005739 Ycf27; Reviewed; Region: orf27; CHL00148 74547005740 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 74547005741 active site 74547005742 phosphorylation site [posttranslational modification] 74547005743 intermolecular recognition site; other site 74547005744 dimerization interface [polypeptide binding]; other site 74547005745 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 74547005746 DNA binding site [nucleotide binding] 74547005747 putative glycerol-3-phosphate acyltransferase PlsX; Provisional; Region: PRK13845 74547005748 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 74547005749 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 74547005750 dimer interface [polypeptide binding]; other site 74547005751 active site 74547005752 CoA binding pocket [chemical binding]; other site 74547005753 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 74547005754 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 74547005755 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 74547005756 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 74547005757 putative acyl-acceptor binding pocket; other site 74547005758 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 74547005759 Hypothetical chloroplast protein Ycf34; Region: Ycf34; pfam10718 74547005760 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 74547005761 active site 74547005762 NTP binding site [chemical binding]; other site 74547005763 metal binding triad [ion binding]; metal-binding site 74547005764 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 74547005765 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 74547005766 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 74547005767 active site lid residues [active] 74547005768 substrate binding pocket [chemical binding]; other site 74547005769 catalytic residues [active] 74547005770 substrate-Mg2+ binding site; other site 74547005771 aspartate-rich region 1; other site 74547005772 aspartate-rich region 2; other site 74547005773 phytoene desaturase; Region: phytoene_desat; TIGR02731 74547005774 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 74547005775 Cyanobacterial and plastid NDH-1 subunit M; Region: NdhM; pfam10664 74547005776 Protein of unknown function (DUF3172); Region: DUF3172; pfam11371 74547005777 1 probable transmembrane helix predicted for by TMHMM2.0 74547005778 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 74547005779 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 74547005780 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 74547005781 putative dimerization interface [polypeptide binding]; other site 74547005782 NnrU protein; Region: NnrU; cl17713 74547005783 3 probable transmembrane helices predicted by TMHMM2.0 74547005784 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07376 74547005785 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 74547005786 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 74547005787 NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010 74547005788 15 probable transmembrane helices predicted by TMHMM2.0 74547005789 NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK02546 74547005790 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 74547005791 13 probable transmembrane helices predicted by TMHMM2.0 74547005792 ScpA/B protein; Region: ScpA_ScpB; cl00598 74547005793 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 74547005794 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 74547005795 active site 74547005796 Substrate binding site; other site 74547005797 Mg++ binding site; other site 74547005798 Left-handed parallel beta-Helix (LbH) domain of a group of proteins with similarity to glucose-1-phosphate adenylyltransferase: Included in this family are glucose-1-phosphate adenylyltransferase, mannose-1-phosphate guanylyltransferase, and the...; Region: LbH_G1P_AT_C_like; cd03356 74547005799 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 74547005800 FAD binding site [chemical binding]; other site 74547005801 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 74547005802 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 74547005803 DNA binding residues [nucleotide binding] 74547005804 dimerization interface [polypeptide binding]; other site 74547005805 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 74547005806 putative dimer interface [polypeptide binding]; other site 74547005807 putative active site [active] 74547005808 putative phosphate binding site [ion binding]; other site 74547005809 putative metal binding residues [ion binding]; other site 74547005810 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02645 74547005811 ATP-NAD kinase; Region: NAD_kinase; pfam01513 74547005812 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 74547005813 3 probable transmembrane helices predicted by TMHMM2.0 74547005814 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 74547005815 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 74547005816 NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213 74547005817 5 probable transmembrane helices predicted by TMHMM2.0 74547005818 NADH-plastoquinone oxidoreductase subunit I protein; Region: ndhI; TIGR00403 74547005819 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 74547005820 NADH dehydrogenase; Region: NADHdh; cl00469 74547005821 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 74547005822 6 probable transmembrane helices predicted by TMHMM2.0 74547005823 citrate synthase; Provisional; Region: PRK14036 74547005824 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 74547005825 oxalacetate binding site [chemical binding]; other site 74547005826 citrylCoA binding site [chemical binding]; other site 74547005827 coenzyme A binding site [chemical binding]; other site 74547005828 catalytic triad [active] 74547005829 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 74547005830 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 74547005831 catalytic core [active] 74547005832 Protein of unknown function (DUF3352); Region: DUF3352; pfam11832 74547005833 1 probable transmembrane helix predicted for by TMHMM2.0 74547005834 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 74547005835 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 74547005836 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 74547005837 pyridoxal 5'-phosphate binding site [chemical binding]; other site 74547005838 catalytic residue [active] 74547005839 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 74547005840 putative rRNA binding site [nucleotide binding]; other site 74547005841 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 74547005842 ligand-binding site [chemical binding]; other site 74547005843 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 74547005844 Domain of unknown function DUF20; Region: UPF0118; pfam01594 74547005845 7 probable transmembrane helices predicted by TMHMM2.0 74547005846 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 74547005847 7 probable transmembrane helices predicted by TMHMM2.0 74547005848 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 74547005849 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 74547005850 7 probable transmembrane helices predicted by TMHMM2.0 74547005851 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 74547005852 7 probable transmembrane helices predicted by TMHMM2.0 74547005853 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 74547005854 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 74547005855 NAD(P) binding site [chemical binding]; other site 74547005856 active site 74547005857 FAD binding domain; Region: FAD_binding_4; pfam01565 74547005858 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 74547005859 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 74547005860 8 probable transmembrane helices predicted by TMHMM2.0 74547005861 6 probable transmembrane helices predicted by TMHMM2.0 74547005862 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 74547005863 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 74547005864 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 74547005865 active site 74547005866 Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580 74547005867 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 74547005868 Magnesium-protoporphyrin IX methyltransferase C-terminus; Region: Mg-por_mtran_C; pfam07109 74547005869 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 74547005870 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 74547005871 active site 74547005872 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 74547005873 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 74547005874 active site 74547005875 phosphorylation site [posttranslational modification] 74547005876 intermolecular recognition site; other site 74547005877 dimerization interface [polypeptide binding]; other site 74547005878 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 74547005879 DNA binding residues [nucleotide binding] 74547005880 dimerization interface [polypeptide binding]; other site 74547005881 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 74547005882 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 74547005883 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 74547005884 catalytic residue [active] 74547005885 6 probable transmembrane helices predicted by TMHMM2.0 74547005886 4 probable transmembrane helices predicted by TMHMM2.0 74547005887 MraW methylase family; Region: Methyltransf_5; cl17771 74547005888 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 74547005889 NAD(P)H-quinone oxidoreductase subunit H; Validated; Region: PRK07415 74547005890 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 74547005891 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 74547005892 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 74547005893 active site 74547005894 2 probable transmembrane helices predicted by TMHMM2.0 74547005895 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 74547005896 active site 74547005897 CoA binding site [chemical binding]; other site 74547005898 AMP binding site [chemical binding]; other site 74547005899 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 74547005900 o-succinylbenzoate synthase; Region: menC_gamma/gm+; TIGR01927 74547005901 active site 74547005902 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK07419 74547005903 9 probable transmembrane helices predicted by TMHMM2.0 74547005904 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 74547005905 chorismate binding enzyme; Region: Chorismate_bind; cl10555 74547005906 glutathione synthetase; Provisional; Region: PRK05246 74547005907 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 74547005908 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 74547005909 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 74547005910 GSH binding site [chemical binding]; other site 74547005911 catalytic residues [active] 74547005912 peptide chain release factor 2; Validated; Region: prfB; PRK00578 74547005913 This domain is found in peptide chain release factors; Region: PCRF; smart00937 74547005914 RF-1 domain; Region: RF-1; pfam00472 74547005915 Protein of unknown function (DUF3285); Region: DUF3285; pfam11688 74547005916 1 probable transmembrane helix predicted for by TMHMM2.0 74547005917 probable rRNA maturation factor YbeY; Region: TIGR00043 74547005918 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 74547005919 3 probable transmembrane helices predicted by TMHMM2.0 74547005920 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 74547005921 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 74547005922 glutamine binding [chemical binding]; other site 74547005923 catalytic triad [active] 74547005924 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 74547005925 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 74547005926 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 74547005927 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 74547005928 pyridoxal 5'-phosphate binding site [chemical binding]; other site 74547005929 homodimer interface [polypeptide binding]; other site 74547005930 catalytic residue [active] 74547005931 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 74547005932 arginine-tRNA ligase; Region: PLN02286 74547005933 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 74547005934 active site 74547005935 HIGH motif; other site 74547005936 KMSK motif region; other site 74547005937 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 74547005938 tRNA binding surface [nucleotide binding]; other site 74547005939 anticodon binding site; other site 74547005940 Transposase IS200 like; Region: Y1_Tnp; pfam01797 74547005941 hypothetical 74547005942 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 74547005943 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 74547005944 dimerization interface [polypeptide binding]; other site 74547005945 active site 74547005946 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 74547005947 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 74547005948 trmE is a tRNA modification GTPase; Region: trmE; cd04164 74547005949 G1 box; other site 74547005950 GTP/Mg2+ binding site [chemical binding]; other site 74547005951 Switch I region; other site 74547005952 G2 box; other site 74547005953 Switch II region; other site 74547005954 G3 box; other site 74547005955 G4 box; other site 74547005956 G5 box; other site 74547005957 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 74547005958 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 74547005959 3 probable transmembrane helices predicted by TMHMM2.0 74547005960 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 74547005961 Mechanosensitive ion channel; Region: MS_channel; pfam00924 74547005962 4 probable transmembrane helices predicted by TMHMM2.0 74547005963 1 probable transmembrane helix predicted for by TMHMM2.0 74547005964 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 74547005965 ABC1 family; Region: ABC1; cl17513 74547005966 ABC1 family; Region: ABC1; cl17513 74547005967 1 probable transmembrane helix predicted for by TMHMM2.0 74547005968 enolase; Provisional; Region: eno; PRK00077 74547005969 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 74547005970 dimer interface [polypeptide binding]; other site 74547005971 metal binding site [ion binding]; metal-binding site 74547005972 substrate binding pocket [chemical binding]; other site 74547005973 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 74547005974 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 74547005975 dimer interface [polypeptide binding]; other site 74547005976 active site 74547005977 metal binding site [ion binding]; metal-binding site 74547005978 glutathione binding site [chemical binding]; other site 74547005979 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 74547005980 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 74547005981 Walker A motif; other site 74547005982 ATP binding site [chemical binding]; other site 74547005983 Walker B motif; other site 74547005984 arginine finger; other site 74547005985 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 74547005986 Walker A motif; other site 74547005987 ATP binding site [chemical binding]; other site 74547005988 Walker B motif; other site 74547005989 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 74547005990 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 74547005991 1 probable transmembrane helix predicted for by TMHMM2.0 74547005992 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 74547005993 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 74547005994 putative homodimer interface [polypeptide binding]; other site 74547005995 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 74547005996 heterodimer interface [polypeptide binding]; other site 74547005997 homodimer interface [polypeptide binding]; other site 74547005998 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 74547005999 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 74547006000 23S rRNA interface [nucleotide binding]; other site 74547006001 L7/L12 interface [polypeptide binding]; other site 74547006002 putative thiostrepton binding site; other site 74547006003 L25 interface [polypeptide binding]; other site 74547006004 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 74547006005 mRNA/rRNA interface [nucleotide binding]; other site 74547006006 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 74547006007 23S rRNA interface [nucleotide binding]; other site 74547006008 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 74547006009 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 74547006010 core dimer interface [polypeptide binding]; other site 74547006011 peripheral dimer interface [polypeptide binding]; other site 74547006012 L10 interface [polypeptide binding]; other site 74547006013 L11 interface [polypeptide binding]; other site 74547006014 putative EF-Tu interaction site [polypeptide binding]; other site 74547006015 putative EF-G interaction site [polypeptide binding]; other site 74547006016 Protein of unknown function (DUF3747); Region: DUF3747; pfam12565 74547006017 1 probable transmembrane helix predicted for by TMHMM2.0 74547006018 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 74547006019 RNA/DNA hybrid binding site [nucleotide binding]; other site 74547006020 active site 74547006021 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 74547006022 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 74547006023 quinone interaction residues [chemical binding]; other site 74547006024 active site 74547006025 catalytic residues [active] 74547006026 FMN binding site [chemical binding]; other site 74547006027 substrate binding site [chemical binding]; other site 74547006028 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 74547006029 1 probable transmembrane helix predicted for by TMHMM2.0 74547006030 1 probable transmembrane helix predicted for by TMHMM2.0 74547006031 Secretin and TonB N terminus short domain; Region: STN; pfam07660 74547006032 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 74547006033 1 probable transmembrane helix predicted for by TMHMM2.0 74547006034 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 74547006035 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 74547006036 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 74547006037 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 74547006038 TPR repeat; Region: TPR_11; pfam13414 74547006039 binding surface 74547006040 TPR motif; other site 74547006041 1 probable transmembrane helix predicted for by TMHMM2.0 74547006042 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 74547006043 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 74547006044 pyridoxal 5'-phosphate binding site [chemical binding]; other site 74547006045 homodimer interface [polypeptide binding]; other site 74547006046 catalytic residue [active] 74547006047 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 74547006048 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 74547006049 active site 74547006050 homodimer interface [polypeptide binding]; other site 74547006051 Protein of unknown function (DUF938); Region: DUF938; pfam06080 74547006052 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 74547006053 GST_N family, Omega-like subfamily; composed of uncharacterized proteins with similarity to class Omega GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_Omega_like; cd03060 74547006054 putative GSH binding site (G-site) [chemical binding]; other site 74547006055 active site cysteine [active] 74547006056 putative C-terminal domain interface [polypeptide binding]; other site 74547006057 putative dimer interface [polypeptide binding]; other site 74547006058 C-terminal, alpha helical domain of an unknown subfamily 5 of Glutathione S-transferases; Region: GST_C_5; cd03196 74547006059 putative N-terminal domain interface [polypeptide binding]; other site 74547006060 putative dimer interface [polypeptide binding]; other site 74547006061 putative substrate binding pocket (H-site) [chemical binding]; other site 74547006062 Protein of unknown function (DUF952); Region: DUF952; pfam06108 74547006063 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 74547006064 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 74547006065 Phosphoglycerate kinase; Region: PGK; pfam00162 74547006066 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 74547006067 substrate binding site [chemical binding]; other site 74547006068 hinge regions; other site 74547006069 ADP binding site [chemical binding]; other site 74547006070 catalytic site [active] 74547006071 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 74547006072 Ligand Binding Site [chemical binding]; other site 74547006073 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 74547006074 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 74547006075 GTP/Mg2+ binding site [chemical binding]; other site 74547006076 G4 box; other site 74547006077 G5 box; other site 74547006078 G1 box; other site 74547006079 Switch I region; other site 74547006080 G2 box; other site 74547006081 G3 box; other site 74547006082 Switch II region; other site 74547006083 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 74547006084 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 74547006085 RNA binding surface [nucleotide binding]; other site 74547006086 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 74547006087 active site 74547006088 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 74547006089 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 74547006090 Walker A/P-loop; other site 74547006091 ATP binding site [chemical binding]; other site 74547006092 Q-loop/lid; other site 74547006093 ABC transporter signature motif; other site 74547006094 Walker B; other site 74547006095 D-loop; other site 74547006096 H-loop/switch region; other site 74547006097 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 74547006098 Walker A/P-loop; other site 74547006099 ATP binding site [chemical binding]; other site 74547006100 Q-loop/lid; other site 74547006101 ABC transporter signature motif; other site 74547006102 Walker B; other site 74547006103 D-loop; other site 74547006104 H-loop/switch region; other site 74547006105 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 74547006106 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 74547006107 Zn2+ binding site [ion binding]; other site 74547006108 Mg2+ binding site [ion binding]; other site 74547006109 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 74547006110 synthetase active site [active] 74547006111 NTP binding site [chemical binding]; other site 74547006112 metal binding site [ion binding]; metal-binding site 74547006113 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 74547006114 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 74547006115 Uncharacterized conserved protein [Function unknown]; Region: COG0397 74547006116 hypothetical protein; Validated; Region: PRK00029 74547006117 2 probable transmembrane helices predicted by TMHMM2.0 74547006118 nif11-like leader peptide domain; Region: ocin_TIGR03798 74547006119 nif11-like leader peptide domain; Region: ocin_TIGR03798 74547006120 nif11-like leader peptide domain; Region: ocin_TIGR03798 74547006121 nif11-like leader peptide domain; Region: ocin_TIGR03798 74547006122 nif11-like leader peptide domain; Region: ocin_TIGR03798 74547006123 nif11-like leader peptide domain; Region: ocin_TIGR03798 74547006124 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 74547006125 active site 74547006126 catalytic residues [active] 74547006127 DNA binding site [nucleotide binding] 74547006128 Int/Topo IB signature motif; other site 74547006129 nif11-like leader peptide domain; Region: ocin_TIGR03798 74547006130 Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862 74547006131 nif11-like leader peptide domain; Region: ocin_TIGR03798 74547006132 nif11-like leader peptide domain; Region: ocin_TIGR03798 74547006133 Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862 74547006134 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 74547006135 heterotetramer interface [polypeptide binding]; other site 74547006136 active site pocket [active] 74547006137 cleavage site 74547006138 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 74547006139 dephospho-CoA kinase; Region: TIGR00152 74547006140 CoA-binding site [chemical binding]; other site 74547006141 ATP-binding [chemical binding]; other site 74547006142 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 74547006143 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 74547006144 GatB domain; Region: GatB_Yqey; smart00845 74547006145 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 74547006146 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 74547006147 bacteriocin-type transport-associated protein; Region: cyc_nuc_ocin; TIGR03896 74547006148 ligand binding site [chemical binding]; other site 74547006149 flexible hinge region; other site 74547006150 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 74547006151 ligand binding site [chemical binding]; other site 74547006152 flexible hinge region; other site 74547006153 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 74547006154 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 74547006155 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 74547006156 Walker A/P-loop; other site 74547006157 ATP binding site [chemical binding]; other site 74547006158 Q-loop/lid; other site 74547006159 ABC transporter signature motif; other site 74547006160 Walker B; other site 74547006161 D-loop; other site 74547006162 H-loop/switch region; other site 74547006163 8 probable transmembrane helices predicted by TMHMM2.0 74547006164 NHLM bacteriocin system secretion protein; Region: NHLM_micro_HlyD; TIGR03794 74547006165 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 74547006166 HlyD family secretion protein; Region: HlyD_3; pfam13437 74547006167 1 probable transmembrane helix predicted for by TMHMM2.0 74547006168 NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein; Region: NHLM_micro_ABC1; TIGR03796 74547006169 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 74547006170 putative active site [active] 74547006171 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 74547006172 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 74547006173 Walker A/P-loop; other site 74547006174 ATP binding site [chemical binding]; other site 74547006175 Q-loop/lid; other site 74547006176 ABC transporter signature motif; other site 74547006177 Walker B; other site 74547006178 D-loop; other site 74547006179 H-loop/switch region; other site 74547006180 5 probable transmembrane helices predicted by TMHMM2.0 74547006181 CHASE2 domain; Region: CHASE2; pfam05226 74547006182 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 74547006183 cyclase homology domain; Region: CHD; cd07302 74547006184 nucleotidyl binding site; other site 74547006185 metal binding site [ion binding]; metal-binding site 74547006186 dimer interface [polypeptide binding]; other site 74547006187 4 probable transmembrane helices predicted by TMHMM2.0 74547006188 FecR protein; Region: FecR; pfam04773 74547006189 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 74547006190 active site 74547006191 multimer interface [polypeptide binding]; other site 74547006192 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 74547006193 Mechanosensitive ion channel; Region: MS_channel; pfam00924 74547006194 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 74547006195 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 74547006196 ligand binding site [chemical binding]; other site 74547006197 flexible hinge region; other site 74547006198 5 probable transmembrane helices predicted by TMHMM2.0 74547006199 arginine decarboxylase; Provisional; Region: PRK05354 74547006200 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 74547006201 dimer interface [polypeptide binding]; other site 74547006202 active site 74547006203 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 74547006204 catalytic residues [active] 74547006205 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 74547006206 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 74547006207 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 74547006208 ligand binding site [chemical binding]; other site 74547006209 flexible hinge region; other site 74547006210 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 74547006211 putative switch regulator; other site 74547006212 non-specific DNA interactions [nucleotide binding]; other site 74547006213 DNA binding site [nucleotide binding] 74547006214 sequence specific DNA binding site [nucleotide binding]; other site 74547006215 putative cAMP binding site [chemical binding]; other site 74547006216 CHASE2 domain; Region: CHASE2; pfam05226 74547006217 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 74547006218 cyclase homology domain; Region: CHD; cd07302 74547006219 nucleotidyl binding site; other site 74547006220 metal binding site [ion binding]; metal-binding site 74547006221 dimer interface [polypeptide binding]; other site 74547006222 4 probable transmembrane helices predicted by TMHMM2.0 74547006223 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 74547006224 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 74547006225 ligand binding site [chemical binding]; other site 74547006226 flexible hinge region; other site 74547006227 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 74547006228 PAP2_like_1 proteins, a sub-family of PAP2, containing bacterial acid phosphatase, vanadium chloroperoxidases and vanadium bromoperoxidases; Region: PAP2_like_1; cd03380 74547006229 active site 74547006230 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 74547006231 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 74547006232 motif 1; other site 74547006233 active site 74547006234 motif 2; other site 74547006235 motif 3; other site 74547006236 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 74547006237 SNF2 Helicase protein; Region: DUF3670; pfam12419 74547006238 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 74547006239 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 74547006240 ATP binding site [chemical binding]; other site 74547006241 putative Mg++ binding site [ion binding]; other site 74547006242 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 74547006243 nucleotide binding region [chemical binding]; other site 74547006244 ATP-binding site [chemical binding]; other site 74547006245 Uncharacterized conserved protein [Function unknown]; Region: COG4279 74547006246 MEKHLA domain; Region: MEKHLA; pfam08670 74547006247 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 74547006248 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 74547006249 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 74547006250 4 probable transmembrane helices predicted by TMHMM2.0 74547006251 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 74547006252 DctM-like transporters; Region: DctM; pfam06808 74547006253 12 probable transmembrane helices predicted by TMHMM2.0 74547006254 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 74547006255 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 74547006256 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 74547006257 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 74547006258 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 74547006259 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 74547006260 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 74547006261 Rubrerythrin [Energy production and conversion]; Region: COG1592 74547006262 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 74547006263 binuclear metal center [ion binding]; other site 74547006264 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 74547006265 iron binding site [ion binding]; other site 74547006266 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 74547006267 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 74547006268 glycine dehydrogenase; Provisional; Region: PRK05367 74547006269 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 74547006270 tetramer interface [polypeptide binding]; other site 74547006271 pyridoxal 5'-phosphate binding site [chemical binding]; other site 74547006272 catalytic residue [active] 74547006273 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 74547006274 tetramer interface [polypeptide binding]; other site 74547006275 pyridoxal 5'-phosphate binding site [chemical binding]; other site 74547006276 catalytic residue [active] 74547006277 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 74547006278 lipoyl attachment site [posttranslational modification]; other site 74547006279 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 74547006280 Aluminium resistance protein; Region: Alum_res; pfam06838 74547006281 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 74547006282 Fatty acid desaturase; Region: FA_desaturase; pfam00487 74547006283 Di-iron ligands [ion binding]; other site 74547006284 5 probable transmembrane helices predicted by TMHMM2.0 74547006285 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 74547006286 Fatty acid desaturase; Region: FA_desaturase; pfam00487 74547006287 Di-iron ligands [ion binding]; other site 74547006288 2 probable transmembrane helices predicted by TMHMM2.0 74547006289 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 74547006290 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 74547006291 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 74547006292 replicative DNA helicase; Region: DnaB; TIGR00665 74547006293 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 74547006294 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 74547006295 Walker A motif; other site 74547006296 ATP binding site [chemical binding]; other site 74547006297 Walker B motif; other site 74547006298 DNA binding loops [nucleotide binding] 74547006299 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 74547006300 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 74547006301 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 74547006302 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 74547006303 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 74547006304 Protein of unknown function (DUF98); Region: DUF98; pfam01947 74547006305 SprT-like family; Region: SprT-like; pfam10263 74547006306 SprT homologues; Region: SprT; cl01182 74547006307 1 probable transmembrane helix predicted for by TMHMM2.0 74547006308 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 74547006309 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 74547006310 nucleotide binding pocket [chemical binding]; other site 74547006311 K-X-D-G motif; other site 74547006312 catalytic site [active] 74547006313 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 74547006314 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 74547006315 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 74547006316 Dimer interface [polypeptide binding]; other site 74547006317 BRCT sequence motif; other site 74547006318 Uncharacterized conserved protein [Function unknown]; Region: COG0398 74547006319 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 74547006320 4 probable transmembrane helices predicted by TMHMM2.0 74547006321 FAD binding domain; Region: FAD_binding_4; pfam01565 74547006322 Berberine and berberine like; Region: BBE; pfam08031 74547006323 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 74547006324 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 74547006325 5 probable transmembrane helices predicted by TMHMM2.0 74547006326 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 74547006327 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 74547006328 6 probable transmembrane helices predicted by TMHMM2.0 74547006329 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 74547006330 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 74547006331 Walker A/P-loop; other site 74547006332 ATP binding site [chemical binding]; other site 74547006333 Q-loop/lid; other site 74547006334 ABC transporter signature motif; other site 74547006335 Walker B; other site 74547006336 D-loop; other site 74547006337 H-loop/switch region; other site 74547006338 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 74547006339 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 74547006340 active site 74547006341 HIGH motif; other site 74547006342 nucleotide binding site [chemical binding]; other site 74547006343 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 74547006344 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 74547006345 active site 74547006346 KMSKS motif; other site 74547006347 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 74547006348 tRNA binding surface [nucleotide binding]; other site 74547006349 anticodon binding site; other site 74547006350 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 74547006351 Protein of unknown function (DUF2488); Region: Ycf54; pfam10674 74547006352 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 74547006353 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 74547006354 catalytic loop [active] 74547006355 iron binding site [ion binding]; other site 74547006356 magnesium-protoporphyrin IX monomethyl ester cyclase; Provisional; Region: PRK13654 74547006357 dinuclear metal binding motif [ion binding]; other site 74547006358 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 74547006359 dimerization interface [polypeptide binding]; other site 74547006360 putative DNA binding site [nucleotide binding]; other site 74547006361 putative Zn2+ binding site [ion binding]; other site 74547006362 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 74547006363 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 74547006364 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 74547006365 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 74547006366 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 74547006367 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 74547006368 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 74547006369 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 74547006370 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 74547006371 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 74547006372 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 74547006373 Walker A motif; other site 74547006374 ATP binding site [chemical binding]; other site 74547006375 Walker B motif; other site 74547006376 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 74547006377 4Fe-4S binding domain; Region: Fer4_5; pfam12801 74547006378 4Fe-4S binding domain; Region: Fer4_5; pfam12801 74547006379 9 probable transmembrane helices predicted by TMHMM2.0 74547006380 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 74547006381 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 74547006382 ABC-ATPase subunit interface; other site 74547006383 dimer interface [polypeptide binding]; other site 74547006384 putative PBP binding regions; other site 74547006385 7 probable transmembrane helices predicted by TMHMM2.0 74547006386 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 74547006387 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 74547006388 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 74547006389 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 74547006390 intersubunit interface [polypeptide binding]; other site 74547006391 TIGR03943 family protein; Region: TIGR03943 74547006392 2 probable transmembrane helices predicted by TMHMM2.0 74547006393 Predicted permease; Region: DUF318; cl17795 74547006394 8 probable transmembrane helices predicted by TMHMM2.0 74547006395 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 74547006396 metal binding site 2 [ion binding]; metal-binding site 74547006397 putative DNA binding helix; other site 74547006398 metal binding site 1 [ion binding]; metal-binding site 74547006399 dimer interface [polypeptide binding]; other site 74547006400 structural Zn2+ binding site [ion binding]; other site 74547006401 Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; pfam09988 74547006402 1 probable transmembrane helix predicted for by TMHMM2.0 74547006403 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 74547006404 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 74547006405 homodimer interface [polypeptide binding]; other site 74547006406 metal binding site [ion binding]; metal-binding site 74547006407 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 74547006408 homodimer interface [polypeptide binding]; other site 74547006409 active site 74547006410 putative chemical substrate binding site [chemical binding]; other site 74547006411 metal binding site [ion binding]; metal-binding site 74547006412 hypothetical protein; Provisional; Region: PRK09256 74547006413 spermidine synthase; Provisional; Region: PRK00811 74547006414 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 74547006415 S-adenosylmethionine binding site [chemical binding]; other site 74547006416 agmatinase; Region: agmatinase; TIGR01230 74547006417 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 74547006418 putative active site [active] 74547006419 Mn binding site [ion binding]; other site 74547006420 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 74547006421 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 74547006422 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 74547006423 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 74547006424 dimer interface [polypeptide binding]; other site 74547006425 anticodon binding site; other site 74547006426 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 74547006427 homodimer interface [polypeptide binding]; other site 74547006428 motif 1; other site 74547006429 active site 74547006430 motif 2; other site 74547006431 GAD domain; Region: GAD; pfam02938 74547006432 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 74547006433 active site 74547006434 motif 3; other site 74547006435 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 74547006436 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 74547006437 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 74547006438 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 74547006439 DNA binding residues [nucleotide binding] 74547006440 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 74547006441 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 74547006442 dimerization interface [polypeptide binding]; other site 74547006443 DPS ferroxidase diiron center [ion binding]; other site 74547006444 ion pore; other site 74547006445 CTP synthetase; Validated; Region: pyrG; PRK05380 74547006446 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 74547006447 Catalytic site [active] 74547006448 active site 74547006449 UTP binding site [chemical binding]; other site 74547006450 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 74547006451 active site 74547006452 putative oxyanion hole; other site 74547006453 catalytic triad [active] 74547006454 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 74547006455 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 74547006456 Ecotin; Region: Ecotin; pfam03974 74547006457 primary substrate binding site; other site 74547006458 inhibition loop; other site 74547006459 secondary substrate binding site; other site 74547006460 dimerization interface [polypeptide binding]; other site 74547006461 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 74547006462 Ligand Binding Site [chemical binding]; other site 74547006463 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 74547006464 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 74547006465 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 74547006466 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 74547006467 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 74547006468 pyridoxal 5'-phosphate binding site [chemical binding]; other site 74547006469 catalytic residue [active] 74547006470 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 74547006471 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 74547006472 Walker A/P-loop; other site 74547006473 ATP binding site [chemical binding]; other site 74547006474 Q-loop/lid; other site 74547006475 ABC transporter signature motif; other site 74547006476 Walker B; other site 74547006477 D-loop; other site 74547006478 H-loop/switch region; other site 74547006479 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 74547006480 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 74547006481 Walker A/P-loop; other site 74547006482 ATP binding site [chemical binding]; other site 74547006483 Q-loop/lid; other site 74547006484 ABC transporter signature motif; other site 74547006485 Walker B; other site 74547006486 D-loop; other site 74547006487 H-loop/switch region; other site 74547006488 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 74547006489 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 74547006490 TM-ABC transporter signature motif; other site 74547006491 8 probable transmembrane helices predicted by TMHMM2.0 74547006492 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 74547006493 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 74547006494 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 74547006495 TM-ABC transporter signature motif; other site 74547006496 8 probable transmembrane helices predicted by TMHMM2.0 74547006497 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 74547006498 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 74547006499 putative ligand binding site [chemical binding]; other site 74547006500 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 74547006501 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 74547006502 UreF; Region: UreF; pfam01730 74547006503 UreE urease accessory protein, C-terminal domain; Region: UreE_C; pfam05194 74547006504 UreD urease accessory protein; Region: UreD; pfam01774 74547006505 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 74547006506 alpha-gamma subunit interface [polypeptide binding]; other site 74547006507 beta-gamma subunit interface [polypeptide binding]; other site 74547006508 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 74547006509 alpha-beta subunit interface [polypeptide binding]; other site 74547006510 urease subunit alpha; Reviewed; Region: ureC; PRK13207 74547006511 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 74547006512 subunit interactions [polypeptide binding]; other site 74547006513 active site 74547006514 flap region; other site 74547006515 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 74547006516 active site 74547006517 SAM binding site [chemical binding]; other site 74547006518 homodimer interface [polypeptide binding]; other site 74547006519 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 74547006520 putative active site [active] 74547006521 ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566 74547006522 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 74547006523 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 74547006524 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 74547006525 6 probable transmembrane helices predicted by TMHMM2.0 74547006526 hypothetical protein; Provisional; Region: PRK07394 74547006527 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 74547006528 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 74547006529 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 74547006530 Major Facilitator Superfamily; Region: MFS_1; pfam07690 74547006531 putative substrate translocation pore; other site 74547006532 11 probable transmembrane helices predicted by TMHMM2.0 74547006533 polyphosphate kinase; Provisional; Region: PRK05443 74547006534 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 74547006535 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 74547006536 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 74547006537 putative domain interface [polypeptide binding]; other site 74547006538 putative active site [active] 74547006539 catalytic site [active] 74547006540 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 74547006541 putative domain interface [polypeptide binding]; other site 74547006542 putative active site [active] 74547006543 catalytic site [active] 74547006544 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 74547006545 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 74547006546 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 74547006547 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 74547006548 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 74547006549 DNA binding residues [nucleotide binding] 74547006550 Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170 74547006551 6 probable transmembrane helices predicted by TMHMM2.0 74547006552 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 74547006553 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 74547006554 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 74547006555 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 74547006556 substrate binding site [chemical binding]; other site 74547006557 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 74547006558 substrate binding site [chemical binding]; other site 74547006559 ligand binding site [chemical binding]; other site 74547006560 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 74547006561 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 74547006562 Cl- selectivity filter; other site 74547006563 Cl- binding residues [ion binding]; other site 74547006564 pore gating glutamate residue; other site 74547006565 dimer interface [polypeptide binding]; other site 74547006566 H+/Cl- coupling transport residue; other site 74547006567 11 probable transmembrane helices predicted by TMHMM2.0 74547006568 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 74547006569 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 74547006570 B12 binding site [chemical binding]; other site 74547006571 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 74547006572 FeS/SAM binding site; other site 74547006573 O-Antigen ligase; Region: Wzy_C; pfam04932 74547006574 9 probable transmembrane helices predicted by TMHMM2.0 74547006575 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 74547006576 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 74547006577 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 74547006578 putative active site [active] 74547006579 putative substrate binding site [chemical binding]; other site 74547006580 putative cosubstrate binding site; other site 74547006581 catalytic site [active] 74547006582 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 74547006583 1 probable transmembrane helix predicted for by TMHMM2.0 74547006584 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 74547006585 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 74547006586 nucleotide binding site [chemical binding]; other site 74547006587 NEF interaction site [polypeptide binding]; other site 74547006588 SBD interface [polypeptide binding]; other site 74547006589 NAD-specific glutamate dehydrogenase; Region: NAD-GH; pfam10712 74547006590 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 74547006591 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 74547006592 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 74547006593 shikimate binding site; other site 74547006594 NAD(P) binding site [chemical binding]; other site 74547006595 4 probable transmembrane helices predicted by TMHMM2.0 74547006596 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 74547006597 argininosuccinate synthase; Provisional; Region: PRK13820 74547006598 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 74547006599 ANP binding site [chemical binding]; other site 74547006600 Substrate Binding Site II [chemical binding]; other site 74547006601 Substrate Binding Site I [chemical binding]; other site 74547006602 2 probable transmembrane helices predicted by TMHMM2.0 74547006603 Protein of unknown function (DUF3134); Region: DUF3134; pfam11332 74547006604 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 74547006605 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 74547006606 Mg++ binding site [ion binding]; other site 74547006607 putative catalytic motif [active] 74547006608 putative substrate binding site [chemical binding]; other site 74547006609 11 probable transmembrane helices predicted by TMHMM2.0 74547006610 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 74547006611 6 probable transmembrane helices predicted by TMHMM2.0 74547006612 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 74547006613 ATP-grasp domain; Region: ATP-grasp; pfam02222 74547006614 sucrose-phosphate synthase, putative, glycosyltransferase domain; Region: sucr_P_syn_N; TIGR02472 74547006615 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 74547006616 putative ADP-binding pocket [chemical binding]; other site 74547006617 sucrose phosphate synthase, sucrose phosphatase-like domain, bacterial; Region: sucr_syn_bact_C; TIGR02471 74547006618 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 74547006619 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 74547006620 1 probable transmembrane helix predicted for by TMHMM2.0 74547006621 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 74547006622 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 74547006623 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 74547006624 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 74547006625 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 74547006626 Walker A/P-loop; other site 74547006627 ATP binding site [chemical binding]; other site 74547006628 Q-loop/lid; other site 74547006629 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 74547006630 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 74547006631 ABC transporter signature motif; other site 74547006632 Walker B; other site 74547006633 D-loop; other site 74547006634 H-loop/switch region; other site 74547006635 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 74547006636 ABC1 family; Region: ABC1; cl17513 74547006637 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 74547006638 threonine synthase; Reviewed; Region: PRK06721 74547006639 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 74547006640 homodimer interface [polypeptide binding]; other site 74547006641 pyridoxal 5'-phosphate binding site [chemical binding]; other site 74547006642 catalytic residue [active]