-- dump date 20140620_000340 -- class Genbank::misc_feature -- table misc_feature_note -- id note 167542000001 DNA polymerase III subunit beta; Validated; Region: PRK05643 167542000002 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 167542000003 putative DNA binding surface [nucleotide binding]; other site 167542000004 dimer interface [polypeptide binding]; other site 167542000005 beta-clamp/clamp loader binding surface; other site 167542000006 beta-clamp/translesion DNA polymerase binding surface; other site 167542000007 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 167542000008 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 167542000009 dimerization interface [polypeptide binding]; other site 167542000010 ATP binding site [chemical binding]; other site 167542000011 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 167542000012 dimerization interface [polypeptide binding]; other site 167542000013 ATP binding site [chemical binding]; other site 167542000014 amidophosphoribosyltransferase; Provisional; Region: PRK09246 167542000015 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 167542000016 active site 167542000017 tetramer interface [polypeptide binding]; other site 167542000018 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 167542000019 active site 167542000020 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit [DNA replication, recombination, and repair]; Region: GyrA; COG0188 167542000021 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 167542000022 CAP-like domain; other site 167542000023 active site 167542000024 primary dimer interface [polypeptide binding]; other site 167542000025 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 167542000026 binding surface 167542000027 TPR motif; other site 167542000028 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 167542000029 binding surface 167542000030 TPR motif; other site 167542000031 TPR repeat; Region: TPR_11; pfam13414 167542000032 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 167542000033 binding surface 167542000034 TPR motif; other site 167542000035 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 167542000036 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 167542000037 Uncharacterized conserved protein [Function unknown]; Region: COG2928 167542000038 transcription antitermination protein NusB; Provisional; Region: nusB; PRK09634 167542000039 putative RNA binding site [nucleotide binding]; other site 167542000040 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 167542000041 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 167542000042 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 167542000043 P loop; other site 167542000044 GTP binding site [chemical binding]; other site 167542000045 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 167542000046 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 167542000047 argininosuccinate lyase; Provisional; Region: PRK00855 167542000048 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 167542000049 active sites [active] 167542000050 tetramer interface [polypeptide binding]; other site 167542000051 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 167542000052 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 167542000053 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 167542000054 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 167542000055 FMN binding site [chemical binding]; other site 167542000056 active site 167542000057 catalytic residues [active] 167542000058 substrate binding site [chemical binding]; other site 167542000059 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 167542000060 SelR domain; Region: SelR; pfam01641 167542000061 GrpE; Region: GrpE; pfam01025 167542000062 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 167542000063 dimer interface [polypeptide binding]; other site 167542000064 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 167542000065 chaperone protein DnaJ; Provisional; Region: PRK14293 167542000066 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 167542000067 HSP70 interaction site [polypeptide binding]; other site 167542000068 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 167542000069 substrate binding site [polypeptide binding]; other site 167542000070 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 167542000071 Zn binding sites [ion binding]; other site 167542000072 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 167542000073 dimer interface [polypeptide binding]; other site 167542000074 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 167542000075 CPxP motif; other site 167542000076 GTPase RsgA; Reviewed; Region: PRK00098 167542000077 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 167542000078 RNA binding site [nucleotide binding]; other site 167542000079 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 167542000080 GTPase/Zn-binding domain interface [polypeptide binding]; other site 167542000081 GTP/Mg2+ binding site [chemical binding]; other site 167542000082 G4 box; other site 167542000083 G5 box; other site 167542000084 G1 box; other site 167542000085 Switch I region; other site 167542000086 G2 box; other site 167542000087 G3 box; other site 167542000088 Switch II region; other site 167542000089 hypothetical protein; Validated; Region: PRK00153 167542000090 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 167542000091 FAD binding domain; Region: FAD_binding_4; pfam01565 167542000092 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 167542000093 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 167542000094 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 167542000095 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 167542000096 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 167542000097 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK07403 167542000098 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 167542000099 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 167542000100 thiamine monophosphate kinase; Provisional; Region: PRK05731 167542000101 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 167542000102 ATP binding site [chemical binding]; other site 167542000103 dimerization interface [polypeptide binding]; other site 167542000104 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 167542000105 active site 167542000106 elongation factor P; Validated; Region: PRK00529 167542000107 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 167542000108 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 167542000109 RNA binding site [nucleotide binding]; other site 167542000110 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 167542000111 RNA binding site [nucleotide binding]; other site 167542000112 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 167542000113 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 167542000114 carboxyltransferase (CT) interaction site; other site 167542000115 biotinylation site [posttranslational modification]; other site 167542000116 4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK02746 167542000117 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 167542000118 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 167542000119 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 167542000120 putative NAD(P) binding site [chemical binding]; other site 167542000121 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 167542000122 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 167542000123 active site 167542000124 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 167542000125 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 167542000126 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 167542000127 catalytic residue [active] 167542000128 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 167542000129 GMP synthase; Reviewed; Region: guaA; PRK00074 167542000130 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 167542000131 AMP/PPi binding site [chemical binding]; other site 167542000132 candidate oxyanion hole; other site 167542000133 catalytic triad [active] 167542000134 potential glutamine specificity residues [chemical binding]; other site 167542000135 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 167542000136 ATP Binding subdomain [chemical binding]; other site 167542000137 Ligand Binding sites [chemical binding]; other site 167542000138 Dimerization subdomain; other site 167542000139 Restriction endonuclease; Region: Mrr_cat_2; pfam13156 167542000140 DEAD-like helicases superfamily; Region: DEXDc; smart00487 167542000141 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 167542000142 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 167542000143 ATP binding site [chemical binding]; other site 167542000144 putative Mg++ binding site [ion binding]; other site 167542000145 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 167542000146 nucleotide binding region [chemical binding]; other site 167542000147 ATP-binding site [chemical binding]; other site 167542000148 Helicase associated domain; Region: HA; pfam03457 167542000149 Helicase associated domain; Region: HA; pfam03457 167542000150 Helicase associated domain; Region: HA; pfam03457 167542000151 Helicase associated domain; Region: HA; pfam03457 167542000152 Helicase associated domain; Region: HA; pfam03457 167542000153 T5orf172 domain; Region: T5orf172; pfam10544 167542000154 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 167542000155 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 167542000156 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 167542000157 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 167542000158 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 167542000159 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 167542000160 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 167542000161 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 167542000162 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 167542000163 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 167542000164 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 167542000165 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 167542000166 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 167542000167 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 167542000168 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 167542000169 motif 1; other site 167542000170 active site 167542000171 motif 2; other site 167542000172 motif 3; other site 167542000173 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 167542000174 DHHA1 domain; Region: DHHA1; pfam02272 167542000175 arginine decarboxylase; Provisional; Region: PRK05354 167542000176 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 167542000177 dimer interface [polypeptide binding]; other site 167542000178 active site 167542000179 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 167542000180 catalytic residues [active] 167542000181 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 167542000182 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 167542000183 active site 167542000184 multimer interface [polypeptide binding]; other site 167542000185 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 167542000186 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 167542000187 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 167542000188 GatB domain; Region: GatB_Yqey; smart00845 167542000189 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 167542000190 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 167542000191 CoA-binding site [chemical binding]; other site 167542000192 ATP-binding [chemical binding]; other site 167542000193 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 167542000194 heterotetramer interface [polypeptide binding]; other site 167542000195 active site pocket [active] 167542000196 cleavage site 167542000197 ParA-like protein; Provisional; Region: PHA02518 167542000198 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 167542000199 P-loop; other site 167542000200 Magnesium ion binding site [ion binding]; other site 167542000201 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 167542000202 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 167542000203 active site 167542000204 catalytic tetrad [active] 167542000205 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 167542000206 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 167542000207 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 167542000208 DNA polymerase Ligase (LigD); Region: LigD_N; pfam13298 167542000209 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 167542000210 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 167542000211 Walker A/P-loop; other site 167542000212 ATP binding site [chemical binding]; other site 167542000213 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 167542000214 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 167542000215 Q-loop/lid; other site 167542000216 ABC transporter signature motif; other site 167542000217 Walker B; other site 167542000218 D-loop; other site 167542000219 H-loop/switch region; other site 167542000220 PRC-barrel domain; Region: PRC; pfam05239 167542000221 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 167542000222 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 167542000223 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 167542000224 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 167542000225 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 167542000226 YGGT family; Region: YGGT; pfam02325 167542000227 Photosystem II reaction centre X protein (PsbX); Region: PsbX; pfam06596 167542000228 Ycf66 protein N-terminus; Region: Ycf66_N; pfam07444 167542000229 Chlorophyll A-B binding protein; Region: Chloroa_b-bind; pfam00504 167542000230 ABC transporter transmembrane region 2; Region: ABC_membrane_2; pfam06472 167542000231 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 167542000232 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 167542000233 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 167542000234 nucleotide binding site/active site [active] 167542000235 HIT family signature motif; other site 167542000236 catalytic residue [active] 167542000237 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 167542000238 active site 167542000239 catalytic residues [active] 167542000240 metal binding site [ion binding]; metal-binding site 167542000241 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 167542000242 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 167542000243 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 167542000244 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 167542000245 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 167542000246 catalytic residue [active] 167542000247 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 167542000248 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 167542000249 sulfate ABC transporter protein; Validated; Region: ycf16; CHL00131 167542000250 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 167542000251 Walker A/P-loop; other site 167542000252 ATP binding site [chemical binding]; other site 167542000253 Q-loop/lid; other site 167542000254 ABC transporter signature motif; other site 167542000255 Walker B; other site 167542000256 D-loop; other site 167542000257 H-loop/switch region; other site 167542000258 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 167542000259 putative ABC transporter; Region: ycf24; CHL00085 167542000260 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 167542000261 phosphoglucomutase; Region: PLN02307 167542000262 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 167542000263 active site 167542000264 substrate binding site [chemical binding]; other site 167542000265 metal binding site [ion binding]; metal-binding site 167542000266 recombination factor protein RarA; Reviewed; Region: PRK13342 167542000267 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167542000268 Walker A motif; other site 167542000269 ATP binding site [chemical binding]; other site 167542000270 Walker B motif; other site 167542000271 arginine finger; other site 167542000272 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 167542000273 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 167542000274 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 167542000275 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 167542000276 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 167542000277 catalytic triad [active] 167542000278 Type III pantothenate kinase; Region: Pan_kinase; cl17198 167542000279 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 167542000280 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 167542000281 Active Sites [active] 167542000282 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 167542000283 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 167542000284 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 167542000285 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 167542000286 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 167542000287 transmembrane helices; other site 167542000288 TrkA-C domain; Region: TrkA_C; pfam02080 167542000289 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 167542000290 TrkA-C domain; Region: TrkA_C; pfam02080 167542000291 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 167542000292 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 167542000293 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 167542000294 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 167542000295 TrkA-N domain; Region: TrkA_N; pfam02254 167542000296 TrkA-C domain; Region: TrkA_C; pfam02080 167542000297 Protein of unknown function (DUF1662); Region: DUF1662; pfam07878 167542000298 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 167542000299 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 167542000300 Walker A/P-loop; other site 167542000301 ATP binding site [chemical binding]; other site 167542000302 Q-loop/lid; other site 167542000303 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 167542000304 ABC transporter signature motif; other site 167542000305 Walker B; other site 167542000306 D-loop; other site 167542000307 ABC transporter; Region: ABC_tran_2; pfam12848 167542000308 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 167542000309 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 167542000310 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 167542000311 protein binding site [polypeptide binding]; other site 167542000312 Protein of unknown function (DUF2973); Region: DUF2973; pfam11189 167542000313 putative high light inducible protein; Region: PHA02337 167542000314 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 167542000315 Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643 167542000316 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 167542000317 active site 167542000318 Outer membrane efflux protein; Region: OEP; pfam02321 167542000319 Outer membrane efflux protein; Region: OEP; pfam02321 167542000320 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 167542000321 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 167542000322 Protein of unknown function (DUF512); Region: DUF512; pfam04459 167542000323 Protein of unknown function (DUF3120); Region: DUF3120; pfam11318 167542000324 L-aspartate oxidase; Provisional; Region: PRK07395 167542000325 L-aspartate oxidase; Provisional; Region: PRK06175 167542000326 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 167542000327 Vitamin K epoxide reductase family in bacteria and plants; Region: VKOR_1; cd12916 167542000328 substrate binding site [chemical binding]; other site 167542000329 putative active site [active] 167542000330 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 167542000331 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 167542000332 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 167542000333 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 167542000334 FeS/SAM binding site; other site 167542000335 TRAM domain; Region: TRAM; pfam01938 167542000336 Domain of unknown function (DUF4346); Region: DUF4346; pfam14251 167542000337 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 167542000338 Protein of unknown function, DUF482; Region: DUF482; pfam04339 167542000339 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 167542000340 RibD C-terminal domain; Region: RibD_C; cl17279 167542000341 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 167542000342 active site 167542000343 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 167542000344 active site 167542000345 shikimate kinase; Reviewed; Region: aroK; PRK00131 167542000346 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 167542000347 ADP binding site [chemical binding]; other site 167542000348 magnesium binding site [ion binding]; other site 167542000349 putative shikimate binding site; other site 167542000350 Protein of unknown function (DUF3571); Region: DUF3571; pfam12095 167542000351 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 167542000352 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 167542000353 C-terminal domain interface [polypeptide binding]; other site 167542000354 GSH binding site (G-site) [chemical binding]; other site 167542000355 dimer interface [polypeptide binding]; other site 167542000356 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 167542000357 N-terminal domain interface [polypeptide binding]; other site 167542000358 Protein of unknown function (DUF751); Region: DUF751; pfam05421 167542000359 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 167542000360 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 167542000361 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 167542000362 active site 167542000363 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 167542000364 putative hydrophobic ligand binding site [chemical binding]; other site 167542000365 9,9'-di-cis-zeta-carotene desaturase; Region: zeta_caro_desat; TIGR02732 167542000366 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 167542000367 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 167542000368 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 167542000369 TPR motif; other site 167542000370 binding surface 167542000371 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370 167542000372 conserved hypothetical protein; Region: TIGR03492 167542000373 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 167542000374 TIGR01777 family protein; Region: yfcH 167542000375 putative NAD(P) binding site [chemical binding]; other site 167542000376 putative active site [active] 167542000377 Cyanobacterial and plant NDH-1 subunit O; Region: NdhO; pfam11910 167542000378 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 167542000379 HSP70 interaction site [polypeptide binding]; other site 167542000380 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 167542000381 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 167542000382 dimer interface [polypeptide binding]; other site 167542000383 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167542000384 catalytic residue [active] 167542000385 hypothetical protein; Provisional; Region: PRK13683 167542000386 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 167542000387 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 167542000388 Walker A/P-loop; other site 167542000389 ATP binding site [chemical binding]; other site 167542000390 Q-loop/lid; other site 167542000391 ABC transporter signature motif; other site 167542000392 Walker B; other site 167542000393 D-loop; other site 167542000394 H-loop/switch region; other site 167542000395 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 167542000396 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 167542000397 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 167542000398 NAD binding site [chemical binding]; other site 167542000399 substrate binding site [chemical binding]; other site 167542000400 homodimer interface [polypeptide binding]; other site 167542000401 active site 167542000402 Protein of unknown function (DUF563); Region: DUF563; pfam04577 167542000403 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 167542000404 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 167542000405 Walker A/P-loop; other site 167542000406 ATP binding site [chemical binding]; other site 167542000407 Q-loop/lid; other site 167542000408 ABC transporter signature motif; other site 167542000409 Walker B; other site 167542000410 D-loop; other site 167542000411 H-loop/switch region; other site 167542000412 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 167542000413 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 167542000414 active site 167542000415 phosphorylation site [posttranslational modification] 167542000416 intermolecular recognition site; other site 167542000417 dimerization interface [polypeptide binding]; other site 167542000418 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 167542000419 DNA binding site [nucleotide binding] 167542000420 DNA polymerase III subunit delta'; Validated; Region: PRK07399 167542000421 thymidylate kinase; Validated; Region: tmk; PRK00698 167542000422 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 167542000423 TMP-binding site; other site 167542000424 ATP-binding site [chemical binding]; other site 167542000425 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 167542000426 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 167542000427 metal-binding site [ion binding] 167542000428 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 167542000429 Soluble P-type ATPase [General function prediction only]; Region: COG4087 167542000430 photosystem I assembly protein Ycf3; Provisional; Region: PRK02603 167542000431 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 167542000432 binding surface 167542000433 TPR motif; other site 167542000434 DNA repair protein RadA; Provisional; Region: PRK11823 167542000435 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 167542000436 Walker A motif; other site 167542000437 ATP binding site [chemical binding]; other site 167542000438 Walker B motif; other site 167542000439 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 167542000440 Ycf27; Reviewed; Region: orf27; CHL00148 167542000441 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 167542000442 active site 167542000443 phosphorylation site [posttranslational modification] 167542000444 intermolecular recognition site; other site 167542000445 dimerization interface [polypeptide binding]; other site 167542000446 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 167542000447 DNA binding site [nucleotide binding] 167542000448 Fatty acid synthesis protein; Region: FA_synthesis; cl17261 167542000449 putative glycerol-3-phosphate acyltransferase PlsX; Provisional; Region: PRK13845 167542000450 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 167542000451 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 167542000452 dimer interface [polypeptide binding]; other site 167542000453 active site 167542000454 CoA binding pocket [chemical binding]; other site 167542000455 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 167542000456 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 167542000457 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 167542000458 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 167542000459 putative acyl-acceptor binding pocket; other site 167542000460 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 167542000461 Hypothetical chloroplast protein Ycf34; Region: Ycf34; pfam10718 167542000462 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 167542000463 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 167542000464 active site 167542000465 NTP binding site [chemical binding]; other site 167542000466 metal binding triad [ion binding]; metal-binding site 167542000467 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 167542000468 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 167542000469 active site lid residues [active] 167542000470 substrate binding pocket [chemical binding]; other site 167542000471 catalytic residues [active] 167542000472 substrate-Mg2+ binding site; other site 167542000473 aspartate-rich region 1; other site 167542000474 aspartate-rich region 2; other site 167542000475 phytoene desaturase; Region: phytoene_desat; TIGR02731 167542000476 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 167542000477 Cyanobacterial and plastid NDH-1 subunit M; Region: NdhM; pfam10664 167542000478 Protein of unknown function (DUF3172); Region: DUF3172; pfam11371 167542000479 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 167542000480 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 167542000481 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 167542000482 putative dimerization interface [polypeptide binding]; other site 167542000483 Predicted membrane protein [Function unknown]; Region: COG4094 167542000484 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07376 167542000485 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 167542000486 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 167542000487 NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010 167542000488 NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK02546 167542000489 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 167542000490 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 167542000491 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 167542000492 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 167542000493 active site 167542000494 Substrate binding site; other site 167542000495 Mg++ binding site; other site 167542000496 Left-handed parallel beta-Helix (LbH) domain of a group of proteins with similarity to glucose-1-phosphate adenylyltransferase: Included in this family are glucose-1-phosphate adenylyltransferase, mannose-1-phosphate guanylyltransferase, and the...; Region: LbH_G1P_AT_C_like; cd03356 167542000497 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 167542000498 FAD binding site [chemical binding]; other site 167542000499 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 167542000500 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 167542000501 DNA binding residues [nucleotide binding] 167542000502 dimerization interface [polypeptide binding]; other site 167542000503 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 167542000504 putative active site [active] 167542000505 putative metal binding residues [ion binding]; other site 167542000506 signature motif; other site 167542000507 putative dimer interface [polypeptide binding]; other site 167542000508 putative phosphate binding site [ion binding]; other site 167542000509 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02645 167542000510 ATP-NAD kinase; Region: NAD_kinase; pfam01513 167542000511 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 167542000512 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 167542000513 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 167542000514 NADH-plastoquinone oxidoreductase subunit I protein; Region: ndhI; TIGR00403 167542000515 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 167542000516 NADH dehydrogenase; Region: NADHdh; cl00469 167542000517 citrate synthase; Provisional; Region: PRK14036 167542000518 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 167542000519 oxalacetate binding site [chemical binding]; other site 167542000520 citrylCoA binding site [chemical binding]; other site 167542000521 coenzyme A binding site [chemical binding]; other site 167542000522 catalytic triad [active] 167542000523 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 167542000524 active site residue [active] 167542000525 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 167542000526 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 167542000527 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167542000528 catalytic residue [active] 167542000529 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 167542000530 putative rRNA binding site [nucleotide binding]; other site 167542000531 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 167542000532 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 167542000533 Walker A/P-loop; other site 167542000534 ligand-binding site [chemical binding]; other site 167542000535 ATP binding site [chemical binding]; other site 167542000536 AIR carboxylase; Region: AIRC; pfam00731 167542000537 Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580 167542000538 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 167542000539 S-adenosylmethionine binding site [chemical binding]; other site 167542000540 Magnesium-protoporphyrin IX methyltransferase C-terminus; Region: Mg-por_mtran_C; pfam07109 167542000541 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 167542000542 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 167542000543 active site 167542000544 phosphorylation site [posttranslational modification] 167542000545 intermolecular recognition site; other site 167542000546 dimerization interface [polypeptide binding]; other site 167542000547 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 167542000548 DNA binding residues [nucleotide binding] 167542000549 dimerization interface [polypeptide binding]; other site 167542000550 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 167542000551 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 167542000552 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 167542000553 catalytic residue [active] 167542000554 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 167542000555 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 167542000556 S-adenosylmethionine binding site [chemical binding]; other site 167542000557 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 167542000558 NAD(P)H-quinone oxidoreductase subunit H; Validated; Region: PRK07415 167542000559 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 167542000560 active site 167542000561 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 167542000562 acyl-activating enzyme (AAE) consensus motif; other site 167542000563 active site 167542000564 AMP binding site [chemical binding]; other site 167542000565 CoA binding site [chemical binding]; other site 167542000566 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 167542000567 active site 167542000568 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK07419 167542000569 UbiA prenyltransferase family; Region: UbiA; pfam01040 167542000570 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 167542000571 glutathione synthetase; Provisional; Region: PRK05246 167542000572 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 167542000573 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 167542000574 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 167542000575 GSH binding site [chemical binding]; other site 167542000576 catalytic residues [active] 167542000577 peptide chain release factor 2; Validated; Region: prfB; PRK00578 167542000578 PCRF domain; Region: PCRF; pfam03462 167542000579 RF-1 domain; Region: RF-1; pfam00472 167542000580 Protein of unknown function (DUF3285); Region: DUF3285; pfam11688 167542000581 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 167542000582 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 167542000583 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 167542000584 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 167542000585 glutamine binding [chemical binding]; other site 167542000586 catalytic triad [active] 167542000587 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 167542000588 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 167542000589 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 167542000590 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 167542000591 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167542000592 homodimer interface [polypeptide binding]; other site 167542000593 catalytic residue [active] 167542000594 arginine-tRNA ligase; Region: PLN02286 167542000595 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 167542000596 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 167542000597 active site 167542000598 HIGH motif; other site 167542000599 KMSK motif region; other site 167542000600 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 167542000601 tRNA binding surface [nucleotide binding]; other site 167542000602 anticodon binding site; other site 167542000603 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 167542000604 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 167542000605 dimerization interface [polypeptide binding]; other site 167542000606 active site 167542000607 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 167542000608 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 167542000609 trmE is a tRNA modification GTPase; Region: trmE; cd04164 167542000610 G1 box; other site 167542000611 GTP/Mg2+ binding site [chemical binding]; other site 167542000612 Switch I region; other site 167542000613 G2 box; other site 167542000614 Switch II region; other site 167542000615 G3 box; other site 167542000616 G4 box; other site 167542000617 G5 box; other site 167542000618 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 167542000619 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 167542000620 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 167542000621 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 167542000622 Zn2+ binding site [ion binding]; other site 167542000623 Mg2+ binding site [ion binding]; other site 167542000624 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 167542000625 synthetase active site [active] 167542000626 NTP binding site [chemical binding]; other site 167542000627 metal binding site [ion binding]; metal-binding site 167542000628 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 167542000629 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 167542000630 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 167542000631 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 167542000632 Walker A/P-loop; other site 167542000633 ATP binding site [chemical binding]; other site 167542000634 Q-loop/lid; other site 167542000635 ABC transporter signature motif; other site 167542000636 Walker B; other site 167542000637 D-loop; other site 167542000638 H-loop/switch region; other site 167542000639 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 167542000640 Walker A/P-loop; other site 167542000641 ATP binding site [chemical binding]; other site 167542000642 Q-loop/lid; other site 167542000643 ABC transporter signature motif; other site 167542000644 Walker B; other site 167542000645 D-loop; other site 167542000646 H-loop/switch region; other site 167542000647 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 167542000648 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 167542000649 RNA binding surface [nucleotide binding]; other site 167542000650 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 167542000651 active site 167542000652 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 167542000653 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 167542000654 GTP/Mg2+ binding site [chemical binding]; other site 167542000655 G4 box; other site 167542000656 G5 box; other site 167542000657 G1 box; other site 167542000658 Switch I region; other site 167542000659 G2 box; other site 167542000660 G3 box; other site 167542000661 Switch II region; other site 167542000662 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 167542000663 Phosphoglycerate kinase; Region: PGK; pfam00162 167542000664 substrate binding site [chemical binding]; other site 167542000665 hinge regions; other site 167542000666 ADP binding site [chemical binding]; other site 167542000667 catalytic site [active] 167542000668 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 167542000669 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 167542000670 active site 167542000671 homodimer interface [polypeptide binding]; other site 167542000672 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 167542000673 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 167542000674 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167542000675 homodimer interface [polypeptide binding]; other site 167542000676 catalytic residue [active] 167542000677 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 167542000678 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 167542000679 quinone interaction residues [chemical binding]; other site 167542000680 active site 167542000681 catalytic residues [active] 167542000682 FMN binding site [chemical binding]; other site 167542000683 substrate binding site [chemical binding]; other site 167542000684 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 167542000685 RNA/DNA hybrid binding site [nucleotide binding]; other site 167542000686 active site 167542000687 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 167542000688 L11 interface [polypeptide binding]; other site 167542000689 putative EF-Tu interaction site [polypeptide binding]; other site 167542000690 putative EF-G interaction site [polypeptide binding]; other site 167542000691 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 167542000692 23S rRNA interface [nucleotide binding]; other site 167542000693 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 167542000694 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 167542000695 mRNA/rRNA interface [nucleotide binding]; other site 167542000696 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 167542000697 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 167542000698 23S rRNA interface [nucleotide binding]; other site 167542000699 L7/L12 interface [polypeptide binding]; other site 167542000700 putative thiostrepton binding site; other site 167542000701 L25 interface [polypeptide binding]; other site 167542000702 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 167542000703 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 167542000704 putative homodimer interface [polypeptide binding]; other site 167542000705 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 167542000706 heterodimer interface [polypeptide binding]; other site 167542000707 homodimer interface [polypeptide binding]; other site 167542000708 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 167542000709 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 167542000710 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167542000711 Walker A motif; other site 167542000712 ATP binding site [chemical binding]; other site 167542000713 Walker B motif; other site 167542000714 arginine finger; other site 167542000715 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167542000716 Walker A motif; other site 167542000717 ATP binding site [chemical binding]; other site 167542000718 Walker B motif; other site 167542000719 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 167542000720 enolase; Provisional; Region: eno; PRK00077 167542000721 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 167542000722 dimer interface [polypeptide binding]; other site 167542000723 metal binding site [ion binding]; metal-binding site 167542000724 substrate binding pocket [chemical binding]; other site 167542000725 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 167542000726 ABC1 family; Region: ABC1; pfam03109 167542000727 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 167542000728 active site 167542000729 ATP binding site [chemical binding]; other site 167542000730 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 167542000731 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 167542000732 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 167542000733 Nitrogen regulatory protein P-II; Region: P-II; cl00412 167542000734 Domain of unknown function (DUF897); Region: DUF897; pfam05982 167542000735 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 167542000736 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 167542000737 Sulfate transporter family; Region: Sulfate_transp; pfam00916 167542000738 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 167542000739 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 167542000740 dimer interface [polypeptide binding]; other site 167542000741 allosteric magnesium binding site [ion binding]; other site 167542000742 active site 167542000743 aspartate-rich active site metal binding site; other site 167542000744 Schiff base residues; other site 167542000745 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 167542000746 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 167542000747 active site 167542000748 metal binding site [ion binding]; metal-binding site 167542000749 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 167542000750 MutS domain III; Region: MutS_III; pfam05192 167542000751 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 167542000752 Walker A/P-loop; other site 167542000753 ATP binding site [chemical binding]; other site 167542000754 Q-loop/lid; other site 167542000755 ABC transporter signature motif; other site 167542000756 Walker B; other site 167542000757 D-loop; other site 167542000758 H-loop/switch region; other site 167542000759 Smr domain; Region: Smr; pfam01713 167542000760 GTPase CgtA; Reviewed; Region: obgE; PRK12299 167542000761 GTP1/OBG; Region: GTP1_OBG; pfam01018 167542000762 Obg GTPase; Region: Obg; cd01898 167542000763 G1 box; other site 167542000764 GTP/Mg2+ binding site [chemical binding]; other site 167542000765 Switch I region; other site 167542000766 G2 box; other site 167542000767 G3 box; other site 167542000768 Switch II region; other site 167542000769 G4 box; other site 167542000770 G5 box; other site 167542000771 CP12 domain; Region: CP12; pfam02672 167542000772 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 167542000773 putative dimer interface [polypeptide binding]; other site 167542000774 N-terminal domain interface [polypeptide binding]; other site 167542000775 putative substrate binding pocket (H-site) [chemical binding]; other site 167542000776 aspartoacylase; Provisional; Region: PRK02259 167542000777 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 167542000778 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 167542000779 protein I interface; other site 167542000780 D2 interface; other site 167542000781 protein T interface; other site 167542000782 chlorophyll binding site; other site 167542000783 beta carotene binding site; other site 167542000784 pheophytin binding site; other site 167542000785 manganese-stabilizing polypeptide interface; other site 167542000786 CP43 interface; other site 167542000787 protein L interface; other site 167542000788 oxygen evolving complex binding site; other site 167542000789 bromide binding site; other site 167542000790 quinone binding site; other site 167542000791 Fe binding site [ion binding]; other site 167542000792 core light harvesting interface; other site 167542000793 cytochrome b559 alpha subunit interface; other site 167542000794 cytochrome c-550 interface; other site 167542000795 protein J interface; other site 167542000796 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 167542000797 protein I interface; other site 167542000798 D2 interface; other site 167542000799 protein T interface; other site 167542000800 chlorophyll binding site; other site 167542000801 beta carotene binding site; other site 167542000802 pheophytin binding site; other site 167542000803 manganese-stabilizing polypeptide interface; other site 167542000804 CP43 interface; other site 167542000805 protein L interface; other site 167542000806 oxygen evolving complex binding site; other site 167542000807 bromide binding site; other site 167542000808 quinone binding site; other site 167542000809 Fe binding site [ion binding]; other site 167542000810 core light harvesting interface; other site 167542000811 cytochrome b559 alpha subunit interface; other site 167542000812 cytochrome c-550 interface; other site 167542000813 protein J interface; other site 167542000814 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 167542000815 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 167542000816 Tetramer interface [polypeptide binding]; other site 167542000817 active site 167542000818 FMN-binding site [chemical binding]; other site 167542000819 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 167542000820 active site 167542000821 intersubunit interface [polypeptide binding]; other site 167542000822 catalytic residue [active] 167542000823 FtsH Extracellular; Region: FtsH_ext; pfam06480 167542000824 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 167542000825 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167542000826 Walker A motif; other site 167542000827 ATP binding site [chemical binding]; other site 167542000828 Walker B motif; other site 167542000829 arginine finger; other site 167542000830 Peptidase family M41; Region: Peptidase_M41; pfam01434 167542000831 ATP-sulfurylase; Region: ATPS; cd00517 167542000832 ATP sulphurylase; Region: sopT; TIGR00339 167542000833 active site 167542000834 HXXH motif; other site 167542000835 flexible loop; other site 167542000836 Manganese-stabilising protein / photosystem II polypeptide; Region: MSP; cl03326 167542000837 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 167542000838 Flavoprotein; Region: Flavoprotein; pfam02441 167542000839 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 167542000840 Protein of unknown function (DUF2555); Region: DUF2555; pfam10742 167542000841 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 167542000842 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 167542000843 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 167542000844 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 167542000845 active site 167542000846 DNA binding site [nucleotide binding] 167542000847 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 167542000848 Beta-carotene hydroxylase (CrtR), the carotenoid zeaxanthin biosynthetic enzyme catalyzes the addition of hydroxyl groups to the beta-ionone rings of beta-carotene to form zeaxanthin and is found in bacteria and red algae. Carotenoids are important...; Region: CrtR_beta-carotene-hydroxylase; cd03514 167542000849 Fatty acid desaturase; Region: FA_desaturase; pfam00487 167542000850 putative di-iron ligands [ion binding]; other site 167542000851 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 167542000852 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 167542000853 active site 167542000854 HIGH motif; other site 167542000855 nucleotide binding site [chemical binding]; other site 167542000856 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 167542000857 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 167542000858 active site 167542000859 KMSKS motif; other site 167542000860 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 167542000861 tRNA binding surface [nucleotide binding]; other site 167542000862 anticodon binding site; other site 167542000863 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 167542000864 Protein of unknown function (DUF3177); Region: DUF3177; pfam11375 167542000865 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 167542000866 S-adenosylmethionine binding site [chemical binding]; other site 167542000867 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14317 167542000868 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 167542000869 active site 167542000870 substrate binding site [chemical binding]; other site 167542000871 metal binding site [ion binding]; metal-binding site 167542000872 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 167542000873 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 167542000874 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 167542000875 trimer interface [polypeptide binding]; other site 167542000876 active site 167542000877 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; cl17276 167542000878 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 167542000879 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 167542000880 ligand binding site [chemical binding]; other site 167542000881 flexible hinge region; other site 167542000882 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 167542000883 putative switch regulator; other site 167542000884 non-specific DNA interactions [nucleotide binding]; other site 167542000885 DNA binding site [nucleotide binding] 167542000886 sequence specific DNA binding site [nucleotide binding]; other site 167542000887 putative cAMP binding site [chemical binding]; other site 167542000888 Protein of unknown function (DUF3084); Region: DUF3084; pfam11283 167542000889 Uncharacterized protein family (UPF0081); Region: UPF0081; cl17278 167542000890 Protein of unknown function (DUF3146); Region: DUF3146; pfam11344 167542000891 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 167542000892 putative active site [active] 167542000893 catalytic residue [active] 167542000894 photosystem II reaction center protein H; Provisional; Region: psbH; PRK02624 167542000895 photosystem II reaction center protein N; Provisional; Region: psbN; PRK13183 167542000896 photosystem II reaction center I protein I; Provisional; Region: psbI; PRK02655 167542000897 Protein of unknown function (DUF3769); Region: DUF3769; pfam12600 167542000898 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 167542000899 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 167542000900 substrate binding site [chemical binding]; other site 167542000901 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 167542000902 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 167542000903 substrate binding site [chemical binding]; other site 167542000904 ligand binding site [chemical binding]; other site 167542000905 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 167542000906 competence damage-inducible protein A; Provisional; Region: PRK00549 167542000907 putative MPT binding site; other site 167542000908 Competence-damaged protein; Region: CinA; pfam02464 167542000909 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 167542000910 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 167542000911 dimer interface [polypeptide binding]; other site 167542000912 active site 167542000913 glycine-pyridoxal phosphate binding site [chemical binding]; other site 167542000914 folate binding site [chemical binding]; other site 167542000915 Protein of unknown function (DUF3181); Region: DUF3181; pfam11378 167542000916 integral membrane protein MviN; Region: mviN; TIGR01695 167542000917 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 167542000918 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 167542000919 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 167542000920 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Provisional; Region: PRK13371 167542000921 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 167542000922 DoxX; Region: DoxX; pfam07681 167542000923 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 167542000924 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 167542000925 purine monophosphate binding site [chemical binding]; other site 167542000926 dimer interface [polypeptide binding]; other site 167542000927 putative catalytic residues [active] 167542000928 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 167542000929 Predicted esterase [General function prediction only]; Region: COG0400 167542000930 putative hydrolase; Provisional; Region: PRK11460 167542000931 Protein of unknown function (DUF3155); Region: DUF3155; pfam11352 167542000932 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 167542000933 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 167542000934 phosphorylation site [posttranslational modification] 167542000935 dimer interface [polypeptide binding]; other site 167542000936 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 167542000937 ATP binding site [chemical binding]; other site 167542000938 Mg2+ binding site [ion binding]; other site 167542000939 G-X-G motif; other site 167542000940 cobalamin synthase; Reviewed; Region: cobS; PRK00235 167542000941 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 167542000942 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 167542000943 Photosystem II 4 kDa reaction centre component; Region: PsbK; cl03641 167542000944 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 167542000945 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 167542000946 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 167542000947 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 167542000948 Domain of unknown function DUF21; Region: DUF21; pfam01595 167542000949 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 167542000950 Transporter associated domain; Region: CorC_HlyC; smart01091 167542000951 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 167542000952 active site 167542000953 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 167542000954 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 167542000955 RecB family nuclease, putative, TM0106 family; Region: TIGR03491 167542000956 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 167542000957 RNase_H superfamily; Region: RNase_H_2; pfam13482 167542000958 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 167542000959 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 167542000960 active site 167542000961 substrate binding site [chemical binding]; other site 167542000962 metal binding site [ion binding]; metal-binding site 167542000963 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 167542000964 active site 167542000965 dimerization interface [polypeptide binding]; other site 167542000966 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 167542000967 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 167542000968 imidazoleglycerol-phosphate dehydratase; Region: PLN02800 167542000969 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 167542000970 putative active site pocket [active] 167542000971 4-fold oligomerization interface [polypeptide binding]; other site 167542000972 metal binding residues [ion binding]; metal-binding site 167542000973 3-fold/trimer interface [polypeptide binding]; other site 167542000974 enoyl-(acyl carrier protein) reductase; Validated; Region: PRK07370 167542000975 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 167542000976 NAD binding site [chemical binding]; other site 167542000977 homotetramer interface [polypeptide binding]; other site 167542000978 homodimer interface [polypeptide binding]; other site 167542000979 substrate binding site [chemical binding]; other site 167542000980 active site 167542000981 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 167542000982 putative catalytic residue [active] 167542000983 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 167542000984 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 167542000985 inhibitor-cofactor binding pocket; inhibition site 167542000986 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167542000987 catalytic residue [active] 167542000988 deoxyribodipyrimidine photo-lyase, 8-HDF type; Region: photolyase_8HDF; TIGR03556 167542000989 DNA photolyase; Region: DNA_photolyase; pfam00875 167542000990 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 167542000991 dimer interface [polypeptide binding]; other site 167542000992 ADP-ribose binding site [chemical binding]; other site 167542000993 active site 167542000994 nudix motif; other site 167542000995 metal binding site [ion binding]; metal-binding site 167542000996 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 167542000997 catalytic center binding site [active] 167542000998 ATP binding site [chemical binding]; other site 167542000999 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 167542001000 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 167542001001 metal ion-dependent adhesion site (MIDAS); other site 167542001002 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 167542001003 mce related protein; Region: MCE; pfam02470 167542001004 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 167542001005 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 167542001006 Walker A/P-loop; other site 167542001007 ATP binding site [chemical binding]; other site 167542001008 Q-loop/lid; other site 167542001009 ABC transporter signature motif; other site 167542001010 Walker B; other site 167542001011 D-loop; other site 167542001012 H-loop/switch region; other site 167542001013 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 167542001014 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 167542001015 phosphate binding site [ion binding]; other site 167542001016 putative substrate binding pocket [chemical binding]; other site 167542001017 dimer interface [polypeptide binding]; other site 167542001018 NADH dehydrogenase subunit J; Provisional; Region: PRK12494 167542001019 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 167542001020 NADH dehydrogenase subunit K; Region: ndhK; CHL00023 167542001021 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 167542001022 Rubredoxin [Energy production and conversion]; Region: COG1773 167542001023 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 167542001024 iron binding site [ion binding]; other site 167542001025 Ycf48-like protein; Provisional; Region: PRK13684 167542001026 cytochrome b559 subunit alpha; Provisional; Region: psbE; PRK02557 167542001027 Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits; Region: Cytochrom_B559; pfam00283 167542001028 Lumenal portion of Cytochrome b559, alpha (gene psbE) subunit; Region: Cytochrom_B559a; pfam00284 167542001029 cytochrome b559 subunit beta; Provisional; Region: psbF; PRK02561 167542001030 PsbL protein; Region: PsbL; cl03581 167542001031 photosystem II reaction center protein J; Provisional; Region: PRK02565 167542001032 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 167542001033 pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169 167542001034 selenium donor protein; Region: selD; TIGR00476 167542001035 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 167542001036 dimerization interface [polypeptide binding]; other site 167542001037 putative ATP binding site [chemical binding]; other site 167542001038 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 167542001039 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 167542001040 active site 167542001041 NTP binding site [chemical binding]; other site 167542001042 metal binding triad [ion binding]; metal-binding site 167542001043 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 167542001044 Part of AAA domain; Region: AAA_19; pfam13245 167542001045 Family description; Region: UvrD_C_2; pfam13538 167542001046 Phycobilisome protein; Region: Phycobilisome; cl08227 167542001047 CpeS-like protein; Region: CpeS; pfam09367 167542001048 S-adenosylmethionine synthetase; Validated; Region: PRK05250 167542001049 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 167542001050 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 167542001051 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 167542001052 30S ribosomal protein S1; Reviewed; Region: PRK07400 167542001053 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 167542001054 RNA binding site [nucleotide binding]; other site 167542001055 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 167542001056 RNA binding site [nucleotide binding]; other site 167542001057 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 167542001058 RNA binding site [nucleotide binding]; other site 167542001059 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 167542001060 Transcription factor S-II (TFIIS); Region: TFIIS_C; cl02609 167542001061 ATP cone domain; Region: ATP-cone; pfam03477 167542001062 photosystem II chlorophyll-binding protein CP47; Region: PS_II_CP47; TIGR03039 167542001063 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 167542001064 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 167542001065 catalytic loop [active] 167542001066 iron binding site [ion binding]; other site 167542001067 photosystem II reaction center protein M; Provisional; Region: psbM; PRK14094 167542001068 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 167542001069 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 167542001070 S-adenosylmethionine binding site [chemical binding]; other site 167542001071 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 167542001072 cell division topological specificity factor MinE; Provisional; Region: PRK13988 167542001073 septum site-determining protein MinD; Region: minD_bact; TIGR01968 167542001074 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 167542001075 P-loop; other site 167542001076 ADP binding residues [chemical binding]; other site 167542001077 Switch I; other site 167542001078 Switch II; other site 167542001079 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 167542001080 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 167542001081 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 167542001082 Zn2+ binding site [ion binding]; other site 167542001083 Mg2+ binding site [ion binding]; other site 167542001084 carboxyl-terminal processing protease; Provisional; Region: PLN00049 167542001085 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 167542001086 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 167542001087 protein binding site [polypeptide binding]; other site 167542001088 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 167542001089 Catalytic dyad [active] 167542001090 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 167542001091 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 167542001092 Qi binding site; other site 167542001093 intrachain domain interface; other site 167542001094 interchain domain interface [polypeptide binding]; other site 167542001095 heme bH binding site [chemical binding]; other site 167542001096 heme bL binding site [chemical binding]; other site 167542001097 Qo binding site; other site 167542001098 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 167542001099 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 167542001100 interchain domain interface [polypeptide binding]; other site 167542001101 intrachain domain interface; other site 167542001102 Qi binding site; other site 167542001103 Qo binding site; other site 167542001104 Alkaline and neutral invertase; Region: Glyco_hydro_100; pfam12899 167542001105 formamidopyrimidine-DNA glycosylase; Provisional; Region: PRK13945 167542001106 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 167542001107 DNA binding site [nucleotide binding] 167542001108 catalytic residue [active] 167542001109 H2TH interface [polypeptide binding]; other site 167542001110 putative catalytic residues [active] 167542001111 turnover-facilitating residue; other site 167542001112 intercalation triad [nucleotide binding]; other site 167542001113 8OG recognition residue [nucleotide binding]; other site 167542001114 putative reading head residues; other site 167542001115 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 167542001116 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 167542001117 photosystem I reaction center subunit IV; Provisional; Region: PRK02749 167542001118 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 167542001119 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 167542001120 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 167542001121 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 167542001122 NAD(P) binding site [chemical binding]; other site 167542001123 catalytic residues [active] 167542001124 Rhomboid family; Region: Rhomboid; cl11446 167542001125 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 167542001126 Coenzyme A binding pocket [chemical binding]; other site 167542001127 Protein of unknown function (DUF3104); Region: DUF3104; pfam11302 167542001128 conserved hypothetical protein, TIGR03894 family; Region: chp_P_marinus_1 167542001129 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 167542001130 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 167542001131 Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862 167542001132 twin arginine translocase protein A; Provisional; Region: tatA; PRK14857 167542001133 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 167542001134 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 167542001135 catalytic triad [active] 167542001136 Protein of unknown function (DUF4090); Region: DUF4090; pfam13319 167542001137 hypothetical protein; Provisional; Region: PRK09256 167542001138 Protein of unknown function (DUF1651); Region: DUF1651; pfam07864 167542001139 CAAX protease self-immunity; Region: Abi; pfam02517 167542001140 Glycosyl transferase family 11; Region: Glyco_transf_11; pfam01531 167542001141 GDP-fucose protein O-fucosyltransferase and related proteins; Region: O-FucT_like; cl16914 167542001142 GDP-Fucose binding site [chemical binding]; other site 167542001143 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 167542001144 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 167542001145 active site 167542001146 Protein of unknown function (DUF1330); Region: DUF1330; pfam07045 167542001147 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 167542001148 DNA photolyase; Region: DNA_photolyase; pfam00875 167542001149 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 167542001150 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 167542001151 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 167542001152 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 167542001153 substrate binding site [chemical binding]; other site 167542001154 dimer interface [polypeptide binding]; other site 167542001155 ATP binding site [chemical binding]; other site 167542001156 Cupin superfamily (DUF985); Region: Cupin_5; cl01418 167542001157 Methyltransferase domain; Region: Methyltransf_23; pfam13489 167542001158 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 167542001159 S-adenosylmethionine binding site [chemical binding]; other site 167542001160 SAM dependent carboxyl methyltransferase; Region: Methyltransf_7; cl04109 167542001161 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 167542001162 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 167542001163 NAD(P) binding pocket [chemical binding]; other site 167542001164 sarcosine oxidase, monomeric form; Region: soxA_mon; TIGR01377 167542001165 hydroxyglutarate oxidase; Provisional; Region: PRK11728 167542001166 DNA repair protein RAD51; Region: recomb_RAD51; TIGR02239 167542001167 Uncharacterized conserved protein [Function unknown]; Region: COG0398 167542001168 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 167542001169 PGAP1-like protein; Region: PGAP1; pfam07819 167542001170 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 167542001171 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 167542001172 active site 167542001173 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08642 167542001174 putative beta-ketoacyl acyl carrier protein [ACP]reductase (BKR), subgroup 2, classical (c) SDR; Region: BKR_2_SDR_c; cd05349 167542001175 putative NAD(P) binding site [chemical binding]; other site 167542001176 active site 167542001177 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 167542001178 Cupin domain; Region: Cupin_2; pfam07883 167542001179 Protein of unknown function (DUF1651); Region: DUF1651; pfam07864 167542001180 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 167542001181 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 167542001182 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 167542001183 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 167542001184 additional DNA contacts [nucleotide binding]; other site 167542001185 mismatch recognition site; other site 167542001186 active site 167542001187 zinc binding site [ion binding]; other site 167542001188 DNA intercalation site [nucleotide binding]; other site 167542001189 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 167542001190 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 167542001191 cofactor binding site; other site 167542001192 DNA binding site [nucleotide binding] 167542001193 substrate interaction site [chemical binding]; other site 167542001194 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 167542001195 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 167542001196 DNA binding site [nucleotide binding] 167542001197 active site 167542001198 Int/Topo IB signature motif; other site 167542001199 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 167542001200 Dehydroquinase class II; Region: DHquinase_II; pfam01220 167542001201 active site 167542001202 trimer interface [polypeptide binding]; other site 167542001203 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 167542001204 active site 167542001205 dinuclear metal binding site [ion binding]; other site 167542001206 dimerization interface [polypeptide binding]; other site 167542001207 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 167542001208 active site 167542001209 SAM binding site [chemical binding]; other site 167542001210 homodimer interface [polypeptide binding]; other site 167542001211 Domain of unknown function (DUF1823); Region: DUF1823; pfam08853 167542001212 GTP-binding protein Der; Reviewed; Region: PRK00093 167542001213 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 167542001214 G1 box; other site 167542001215 GTP/Mg2+ binding site [chemical binding]; other site 167542001216 Switch I region; other site 167542001217 G2 box; other site 167542001218 Switch II region; other site 167542001219 G3 box; other site 167542001220 G4 box; other site 167542001221 G5 box; other site 167542001222 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 167542001223 G1 box; other site 167542001224 GTP/Mg2+ binding site [chemical binding]; other site 167542001225 Switch I region; other site 167542001226 G2 box; other site 167542001227 G3 box; other site 167542001228 Switch II region; other site 167542001229 G4 box; other site 167542001230 G5 box; other site 167542001231 Cobalt transport protein; Region: CbiQ; cl00463 167542001232 Protein of unknown function (DUF3539); Region: DUF3539; pfam12058 167542001233 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 167542001234 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 167542001235 catalytic residue [active] 167542001236 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 167542001237 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 167542001238 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 167542001239 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 167542001240 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 167542001241 Recombination protein O N terminal; Region: RecO_N; pfam11967 167542001242 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 167542001243 Recombination protein O C terminal; Region: RecO_C; pfam02565 167542001244 Class I aldolases; Region: Aldolase_Class_I; cl17187 167542001245 catalytic residue [active] 167542001246 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 167542001247 30S subunit binding site; other site 167542001248 lipoate-protein ligase B; Provisional; Region: PRK14344 167542001249 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 167542001250 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 167542001251 acyl-activating enzyme (AAE) consensus motif; other site 167542001252 putative AMP binding site [chemical binding]; other site 167542001253 putative active site [active] 167542001254 putative CoA binding site [chemical binding]; other site 167542001255 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 167542001256 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 167542001257 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 167542001258 E3 interaction surface; other site 167542001259 lipoyl attachment site [posttranslational modification]; other site 167542001260 e3 binding domain; Region: E3_binding; pfam02817 167542001261 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 167542001262 Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547 167542001263 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 167542001264 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 167542001265 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 167542001266 dimer interface [polypeptide binding]; other site 167542001267 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167542001268 catalytic residue [active] 167542001269 cystathionine gamma-synthase; Reviewed; Region: PRK08247 167542001270 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 167542001271 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 167542001272 catalytic residue [active] 167542001273 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 167542001274 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 167542001275 homodimer interface [polypeptide binding]; other site 167542001276 substrate-cofactor binding pocket; other site 167542001277 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167542001278 catalytic residue [active] 167542001279 ribosomal protein S4; Reviewed; Region: rps4; CHL00113 167542001280 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 167542001281 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 167542001282 RNA binding surface [nucleotide binding]; other site 167542001283 hypothetical protein; Provisional; Region: PRK14390 167542001284 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 167542001285 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 167542001286 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 167542001287 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 167542001288 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 167542001289 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167542001290 NAD(P) binding site [chemical binding]; other site 167542001291 active site 167542001292 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 167542001293 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 167542001294 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 167542001295 catalytic residue [active] 167542001296 Methyltransferase domain; Region: Methyltransf_31; pfam13847 167542001297 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 167542001298 S-adenosylmethionine binding site [chemical binding]; other site 167542001299 NifU-like domain; Region: NifU; pfam01106 167542001300 malate:quinone oxidoreductase; Validated; Region: PRK05257 167542001301 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 167542001302 GTP-binding protein LepA; Provisional; Region: PRK05433 167542001303 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 167542001304 G1 box; other site 167542001305 putative GEF interaction site [polypeptide binding]; other site 167542001306 GTP/Mg2+ binding site [chemical binding]; other site 167542001307 Switch I region; other site 167542001308 G2 box; other site 167542001309 G3 box; other site 167542001310 Switch II region; other site 167542001311 G4 box; other site 167542001312 G5 box; other site 167542001313 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 167542001314 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 167542001315 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 167542001316 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 167542001317 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 167542001318 dimer interface [polypeptide binding]; other site 167542001319 conserved gate region; other site 167542001320 ABC-ATPase subunit interface; other site 167542001321 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 167542001322 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 167542001323 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 167542001324 Protein of unknown function, DUF393; Region: DUF393; pfam04134 167542001325 TIGR03643 family protein; Region: TIGR03643 167542001326 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 167542001327 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 167542001328 16S rRNA methyltransferase B; Provisional; Region: PRK14901 167542001329 NusB family; Region: NusB; pfam01029 167542001330 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 167542001331 S-adenosylmethionine binding site [chemical binding]; other site 167542001332 Transglycosylase; Region: Transgly; pfam00912 167542001333 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 167542001334 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 167542001335 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 167542001336 UbiA prenyltransferase family; Region: UbiA; pfam01040 167542001337 Protein of unknown function (DUF2862); Region: DUF2862; pfam11061 167542001338 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 167542001339 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 167542001340 substrate binding site [chemical binding]; other site 167542001341 glutamase interaction surface [polypeptide binding]; other site 167542001342 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 167542001343 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 167542001344 S-adenosylmethionine binding site [chemical binding]; other site 167542001345 Protein of unknown function (DUF721); Region: DUF721; pfam05258 167542001346 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 167542001347 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 167542001348 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 167542001349 Walker A/P-loop; other site 167542001350 ATP binding site [chemical binding]; other site 167542001351 Q-loop/lid; other site 167542001352 ABC transporter signature motif; other site 167542001353 Walker B; other site 167542001354 D-loop; other site 167542001355 H-loop/switch region; other site 167542001356 NAD(P)H-quinone oxidoreductase subunit 2; Provisional; Region: PRK02504 167542001357 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 167542001358 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 167542001359 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 167542001360 active site 167542001361 interdomain interaction site; other site 167542001362 putative metal-binding site [ion binding]; other site 167542001363 nucleotide binding site [chemical binding]; other site 167542001364 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 167542001365 domain I; other site 167542001366 DNA binding groove [nucleotide binding] 167542001367 phosphate binding site [ion binding]; other site 167542001368 domain II; other site 167542001369 domain III; other site 167542001370 nucleotide binding site [chemical binding]; other site 167542001371 catalytic site [active] 167542001372 domain IV; other site 167542001373 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 167542001374 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 167542001375 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 167542001376 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 167542001377 putative dimer interface [polypeptide binding]; other site 167542001378 active site pocket [active] 167542001379 putative cataytic base [active] 167542001380 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 167542001381 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 167542001382 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 167542001383 active site 167542001384 catalytic tetrad [active] 167542001385 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 167542001386 Lumazine binding domain; Region: Lum_binding; pfam00677 167542001387 Lumazine binding domain; Region: Lum_binding; pfam00677 167542001388 AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250 167542001389 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 167542001390 Subunit I/III interface [polypeptide binding]; other site 167542001391 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 167542001392 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 167542001393 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 167542001394 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 167542001395 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 167542001396 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 167542001397 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 167542001398 UbiA prenyltransferase family; Region: UbiA; pfam01040 167542001399 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 167542001400 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 167542001401 Walker A/P-loop; other site 167542001402 ATP binding site [chemical binding]; other site 167542001403 Q-loop/lid; other site 167542001404 ABC transporter signature motif; other site 167542001405 Walker B; other site 167542001406 D-loop; other site 167542001407 H-loop/switch region; other site 167542001408 ABC-2 type transporter; Region: ABC2_membrane; cl17235 167542001409 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 167542001410 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 167542001411 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 167542001412 ring oligomerisation interface [polypeptide binding]; other site 167542001413 ATP/Mg binding site [chemical binding]; other site 167542001414 stacking interactions; other site 167542001415 hinge regions; other site 167542001416 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 167542001417 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 167542001418 NAD(P) binding site [chemical binding]; other site 167542001419 homotetramer interface [polypeptide binding]; other site 167542001420 homodimer interface [polypeptide binding]; other site 167542001421 active site 167542001422 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 167542001423 substrate binding site; other site 167542001424 dimer interface; other site 167542001425 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 167542001426 dimer interface [polypeptide binding]; other site 167542001427 catalytic triad [active] 167542001428 prenyltransferase; Reviewed; Region: ubiA; PRK12873 167542001429 UbiA prenyltransferase family; Region: UbiA; pfam01040 167542001430 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 167542001431 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 167542001432 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 167542001433 non-specific DNA binding site [nucleotide binding]; other site 167542001434 salt bridge; other site 167542001435 sequence-specific DNA binding site [nucleotide binding]; other site 167542001436 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 167542001437 active site 167542001438 SAM binding site [chemical binding]; other site 167542001439 homodimer interface [polypeptide binding]; other site 167542001440 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 167542001441 cytochrome f; Region: petA; CHL00037 167542001442 apocytochrome f; Reviewed; Region: PRK02693 167542001443 cytochrome b6-f complex iron-sulfur subunit; Provisional; Region: PRK13474 167542001444 Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802 167542001445 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 167542001446 iron-sulfur cluster [ion binding]; other site 167542001447 [2Fe-2S] cluster binding site [ion binding]; other site 167542001448 Protein of unknown function (DUF3067); Region: DUF3067; pfam11267 167542001449 Sec-independent translocase component C; Provisional; Region: tatC; CHL00182 167542001450 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 167542001451 Domain of unknown function (DUF814); Region: DUF814; pfam05670 167542001452 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 167542001453 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 167542001454 catalytic site [active] 167542001455 G-X2-G-X-G-K; other site 167542001456 photosystem I reaction center subunit IX; Provisional; Region: PRK02733 167542001457 Photosystem I reaction centre subunit III; Region: PSI_PsaF; cl03627 167542001458 UGMP family protein; Validated; Region: PRK09604 167542001459 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 167542001460 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 167542001461 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 167542001462 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 167542001463 HIGH motif; other site 167542001464 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 167542001465 active site 167542001466 KMSKS motif; other site 167542001467 Src Homology 3 domain superfamily; Region: SH3; cl17036 167542001468 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 167542001469 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 167542001470 active site 167542001471 short chain dehydrogenase; Provisional; Region: PRK12367 167542001472 NAD(P) binding site [chemical binding]; other site 167542001473 BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857 167542001474 DRTGG domain; Region: DRTGG; pfam07085 167542001475 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 167542001476 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 167542001477 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 167542001478 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 167542001479 SPFH domain / Band 7 family; Region: Band_7; pfam01145 167542001480 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 167542001481 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 167542001482 inhibitor-cofactor binding pocket; inhibition site 167542001483 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167542001484 catalytic residue [active] 167542001485 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 167542001486 putative catalytic site [active] 167542001487 putative phosphate binding site [ion binding]; other site 167542001488 active site 167542001489 metal binding site A [ion binding]; metal-binding site 167542001490 DNA binding site [nucleotide binding] 167542001491 putative AP binding site [nucleotide binding]; other site 167542001492 putative metal binding site B [ion binding]; other site 167542001493 LytB protein; Region: LYTB; cl00507 167542001494 hypothetical protein; Provisional; Region: PRK04194 167542001495 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 167542001496 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 167542001497 dimer interface [polypeptide binding]; other site 167542001498 conserved gate region; other site 167542001499 putative PBP binding loops; other site 167542001500 ABC-ATPase subunit interface; other site 167542001501 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 167542001502 dimer interface [polypeptide binding]; other site 167542001503 conserved gate region; other site 167542001504 putative PBP binding loops; other site 167542001505 ABC-ATPase subunit interface; other site 167542001506 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 167542001507 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 167542001508 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 167542001509 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914 167542001510 aromatic arch; other site 167542001511 DCoH dimer interaction site [polypeptide binding]; other site 167542001512 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 167542001513 DCoH tetramer interaction site [polypeptide binding]; other site 167542001514 substrate binding site [chemical binding]; other site 167542001515 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 167542001516 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 167542001517 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 167542001518 active site 167542001519 Zn binding site [ion binding]; other site 167542001520 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 167542001521 dimer interface [polypeptide binding]; other site 167542001522 substrate binding site [chemical binding]; other site 167542001523 metal binding sites [ion binding]; metal-binding site 167542001524 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 167542001525 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 167542001526 domain interfaces; other site 167542001527 active site 167542001528 RNA polymerase sigma factor RpoD; Validated; Region: PRK07406 167542001529 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 167542001530 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 167542001531 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 167542001532 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 167542001533 DNA binding residues [nucleotide binding] 167542001534 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 167542001535 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 167542001536 ATP binding site [chemical binding]; other site 167542001537 putative Mg++ binding site [ion binding]; other site 167542001538 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 167542001539 ATP-binding site [chemical binding]; other site 167542001540 Protein of unknown function (DUF3153); Region: DUF3153; pfam11353 167542001541 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 167542001542 feedback inhibition sensing region; other site 167542001543 homohexameric interface [polypeptide binding]; other site 167542001544 nucleotide binding site [chemical binding]; other site 167542001545 N-acetyl-L-glutamate binding site [chemical binding]; other site 167542001546 Protein of unknown function (DUF2854); Region: DUF2854; pfam11016 167542001547 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 167542001548 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 167542001549 ssDNA binding site [nucleotide binding]; other site 167542001550 dimer interface [polypeptide binding]; other site 167542001551 tetramer (dimer of dimers) interface [polypeptide binding]; other site 167542001552 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 167542001553 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 167542001554 CutA1 divalent ion tolerance protein; Region: CutA1; cl00584 167542001555 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 167542001556 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 167542001557 substrate binding site [chemical binding]; other site 167542001558 ATP binding site [chemical binding]; other site 167542001559 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 167542001560 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 167542001561 GDP-binding site [chemical binding]; other site 167542001562 ACT binding site; other site 167542001563 IMP binding site; other site 167542001564 photosystem II protein Psb27; Region: PS_II_psb27; TIGR03044 167542001565 prolyl-tRNA synthetase; Provisional; Region: PRK09194 167542001566 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 167542001567 motif 1; other site 167542001568 dimer interface [polypeptide binding]; other site 167542001569 active site 167542001570 motif 2; other site 167542001571 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 167542001572 putative deacylase active site [active] 167542001573 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 167542001574 active site 167542001575 motif 3; other site 167542001576 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 167542001577 anticodon binding site; other site 167542001578 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 167542001579 dimer interface [polypeptide binding]; other site 167542001580 substrate binding site [chemical binding]; other site 167542001581 metal binding sites [ion binding]; metal-binding site 167542001582 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 167542001583 ArsC family; Region: ArsC; pfam03960 167542001584 putative ArsC-like catalytic residues; other site 167542001585 putative TRX-like catalytic residues [active] 167542001586 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 167542001587 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 167542001588 Catalytic site [active] 167542001589 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 167542001590 dihydroorotase; Provisional; Region: PRK07369 167542001591 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 167542001592 active site 167542001593 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 167542001594 catalytic core [active] 167542001595 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 167542001596 catalytic core [active] 167542001597 CAAX protease self-immunity; Region: Abi; pfam02517 167542001598 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 167542001599 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 167542001600 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 167542001601 transaldolase-like protein; Provisional; Region: PTZ00411 167542001602 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 167542001603 active site 167542001604 dimer interface [polypeptide binding]; other site 167542001605 catalytic residue [active] 167542001606 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 167542001607 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 167542001608 ribosome recycling factor; Reviewed; Region: frr; PRK00083 167542001609 hinge region; other site 167542001610 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 167542001611 putative nucleotide binding site [chemical binding]; other site 167542001612 uridine monophosphate binding site [chemical binding]; other site 167542001613 homohexameric interface [polypeptide binding]; other site 167542001614 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 167542001615 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 167542001616 homodimer interface [polypeptide binding]; other site 167542001617 Walker A motif; other site 167542001618 ATP binding site [chemical binding]; other site 167542001619 hydroxycobalamin binding site [chemical binding]; other site 167542001620 Walker B motif; other site 167542001621 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 167542001622 active site 167542001623 catalytic residues [active] 167542001624 DNA binding site [nucleotide binding] 167542001625 Int/Topo IB signature motif; other site 167542001626 ferrochelatase; Reviewed; Region: hemH; PRK00035 167542001627 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 167542001628 C-terminal domain interface [polypeptide binding]; other site 167542001629 active site 167542001630 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 167542001631 active site 167542001632 N-terminal domain interface [polypeptide binding]; other site 167542001633 acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK07418 167542001634 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 167542001635 PYR/PP interface [polypeptide binding]; other site 167542001636 dimer interface [polypeptide binding]; other site 167542001637 TPP binding site [chemical binding]; other site 167542001638 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 167542001639 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 167542001640 TPP-binding site [chemical binding]; other site 167542001641 dimer interface [polypeptide binding]; other site 167542001642 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 167542001643 Protein of unknown function (DUF1092); Region: DUF1092; pfam06485 167542001644 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 167542001645 RNA binding site [nucleotide binding]; other site 167542001646 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 167542001647 RNA binding site [nucleotide binding]; other site 167542001648 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 167542001649 RNA binding site [nucleotide binding]; other site 167542001650 Creatinine amidohydrolase; Region: Creatininase; pfam02633 167542001651 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 167542001652 dinuclear metal binding motif [ion binding]; other site 167542001653 acyl-ACP reductase; Provisional; Region: PRK14982 167542001654 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 167542001655 NAD binding site [chemical binding]; other site 167542001656 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 167542001657 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 167542001658 short chain dehydrogenase; Provisional; Region: PRK07454 167542001659 classical (c) SDRs; Region: SDR_c; cd05233 167542001660 NAD(P) binding site [chemical binding]; other site 167542001661 active site 167542001662 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 167542001663 GTP cyclohydrolase I; Provisional; Region: PLN03044 167542001664 active site 167542001665 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 167542001666 active site 167542001667 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 167542001668 active site 167542001669 putative substrate binding region [chemical binding]; other site 167542001670 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 167542001671 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 167542001672 photosystem I reaction center subunit XII; Reviewed; Region: psaM; PRK11878 167542001673 protochlorophyllide oxidoreductase; Validated; Region: PRK07453 167542001674 light-dependent protochlorophyllide reductase; Region: LPOR; TIGR01289 167542001675 NAD(P) binding site [chemical binding]; other site 167542001676 active site 167542001677 protochlorophyllide reductase iron-sulfur ATP-binding protein; Provisional; Region: chlL; PRK13185 167542001678 This family of proteins contains bchL and chlL. Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. Three genes, bchL, bchN and bchB, are...; Region: Bchl_like; cd02032 167542001679 P-loop; other site 167542001680 light-independent protochlorophyllide reductase subunit B; Provisional; Region: PRK02910 167542001681 Pchlide_reductase_B: B protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_B; cd01981 167542001682 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 167542001683 light-independent protochlorophyllide reductase subunit N; Provisional; Region: PRK02842 167542001684 light-independent protochlorophyllide reductase, N subunit; Region: DPOR_bchN; TIGR01279 167542001685 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 1; Region: BMC_like_1_repeat1; cd07051 167542001686 putative hexamer interface [polypeptide binding]; other site 167542001687 putative hexagonal pore; other site 167542001688 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 2; Region: BMC_like_1_repeat2; cd07052 167542001689 putative hexamer interface [polypeptide binding]; other site 167542001690 putative hexagonal pore; other site 167542001691 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 167542001692 active site 167542001693 dimerization interface [polypeptide binding]; other site 167542001694 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 167542001695 Carboxysome Shell 1 (CsoS1); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CsoS1; cd07058 167542001696 Hexamer interface [polypeptide binding]; other site 167542001697 Hexagonal pore residue; other site 167542001698 Hexagonal pore; other site 167542001699 ribulose bisophosphate carboxylase; Reviewed; Region: rbcL; PRK04208 167542001700 Ribulose bisphosphate carboxylase large chain; Region: RuBisCO_large; cl08232 167542001701 dimer interface [polypeptide binding]; other site 167542001702 catalytic residue [active] 167542001703 metal binding site [ion binding]; metal-binding site 167542001704 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527 167542001705 multimerization interface [polypeptide binding]; other site 167542001706 Carboxysome shell peptide mid-region; Region: CsoS2_M; pfam12288 167542001707 Carboxysome shell peptide mid-region; Region: CsoS2_M; pfam12288 167542001708 Carboxysome Shell Carbonic Anhydrase; Region: CsoSCA; pfam08936 167542001709 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 167542001710 Hexamer/Pentamer interface [polypeptide binding]; other site 167542001711 central pore; other site 167542001712 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 167542001713 Hexamer/Pentamer interface [polypeptide binding]; other site 167542001714 central pore; other site 167542001715 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cl00942 167542001716 DCoH dimer interaction site [polypeptide binding]; other site 167542001717 aromatic arch; other site 167542001718 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 167542001719 DCoH tetramer interaction site [polypeptide binding]; other site 167542001720 substrate binding site [chemical binding]; other site 167542001721 Protein of unknown function (DUF3136); Region: DUF3136; pfam11334 167542001722 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 167542001723 homotrimer interaction site [polypeptide binding]; other site 167542001724 putative active site [active] 167542001725 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 167542001726 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 167542001727 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 167542001728 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 167542001729 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 167542001730 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 167542001731 Walker A/P-loop; other site 167542001732 ATP binding site [chemical binding]; other site 167542001733 Q-loop/lid; other site 167542001734 ABC transporter signature motif; other site 167542001735 Walker B; other site 167542001736 D-loop; other site 167542001737 H-loop/switch region; other site 167542001738 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 167542001739 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 167542001740 Coenzyme A binding pocket [chemical binding]; other site 167542001741 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 167542001742 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 167542001743 Probable Catalytic site; other site 167542001744 transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282 167542001745 DnaA N-terminal domain; Region: DnaA_N; pfam11638 167542001746 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 167542001747 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167542001748 Walker A motif; other site 167542001749 ATP binding site [chemical binding]; other site 167542001750 Walker B motif; other site 167542001751 arginine finger; other site 167542001752 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 167542001753 DnaA box-binding interface [nucleotide binding]; other site 167542001754 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 167542001755 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 167542001756 C-terminal domain interface [polypeptide binding]; other site 167542001757 GSH binding site (G-site) [chemical binding]; other site 167542001758 dimer interface [polypeptide binding]; other site 167542001759 N-terminal domain interface [polypeptide binding]; other site 167542001760 dimer interface [polypeptide binding]; other site 167542001761 substrate binding pocket (H-site) [chemical binding]; other site 167542001762 Glutathione S-transferase, C-terminal domain; Region: GST_C_2; pfam13410 167542001763 glutathione reductase; Validated; Region: PRK06116 167542001764 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 167542001765 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 167542001766 K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367 167542001767 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 167542001768 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 167542001769 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 167542001770 active site 167542001771 substrate binding pocket [chemical binding]; other site 167542001772 dimer interface [polypeptide binding]; other site 167542001773 PspC domain; Region: PspC; cl00864 167542001774 NADH dehydrogenase transmembrane subunit; Region: NdhL; pfam10716 167542001775 Protein of unknown function (DUF3007); Region: DUF3007; pfam11460 167542001776 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 167542001777 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 167542001778 substrate binding site [chemical binding]; other site 167542001779 active site 167542001780 catalytic residues [active] 167542001781 heterodimer interface [polypeptide binding]; other site 167542001782 AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250 167542001783 YciI-like protein; Reviewed; Region: PRK12864 167542001784 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 167542001785 Uncharacterized conserved protein [Function unknown]; Region: COG3339 167542001786 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 167542001787 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 167542001788 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 167542001789 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 167542001790 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 167542001791 DNA binding residues [nucleotide binding] 167542001792 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 167542001793 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 167542001794 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 167542001795 metal binding site [ion binding]; metal-binding site 167542001796 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 167542001797 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 167542001798 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167542001799 Walker A motif; other site 167542001800 ATP binding site [chemical binding]; other site 167542001801 Walker B motif; other site 167542001802 arginine finger; other site 167542001803 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167542001804 Walker A motif; other site 167542001805 ATP binding site [chemical binding]; other site 167542001806 Walker B motif; other site 167542001807 arginine finger; other site 167542001808 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 167542001809 plastocyanin; Provisional; Region: PRK02710 167542001810 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 167542001811 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 167542001812 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167542001813 active site 167542001814 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 167542001815 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 167542001816 substrate binding site [chemical binding]; other site 167542001817 active site 167542001818 glycogen branching enzyme; Provisional; Region: PRK05402 167542001819 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 167542001820 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 167542001821 active site 167542001822 catalytic site [active] 167542001823 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 167542001824 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 167542001825 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 167542001826 Domain of unknown function (DUF4332); Region: DUF4332; pfam14229 167542001827 Protein of function (DUF2518); Region: DUF2518; pfam10726 167542001828 Family of unknown function (DUF490); Region: DUF490; pfam04357 167542001829 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 167542001830 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 167542001831 putative catalytic cysteine [active] 167542001832 Dihydroneopterin aldolase; Region: FolB; smart00905 167542001833 active site 167542001834 Lipase (class 2); Region: Lipase_2; pfam01674 167542001835 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 167542001836 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 167542001837 active site 167542001838 Zn binding site [ion binding]; other site 167542001839 NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK12561 167542001840 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 167542001841 homoserine kinase; Provisional; Region: PRK01212 167542001842 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 167542001843 glucokinase, proteobacterial type; Region: glk; TIGR00749 167542001844 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 167542001845 nucleotide binding site [chemical binding]; other site 167542001846 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 167542001847 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 167542001848 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 167542001849 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 167542001850 active site 167542001851 dimer interface [polypeptide binding]; other site 167542001852 motif 1; other site 167542001853 motif 2; other site 167542001854 motif 3; other site 167542001855 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 167542001856 anticodon binding site; other site 167542001857 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 167542001858 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 167542001859 active site 167542001860 HIGH motif; other site 167542001861 dimer interface [polypeptide binding]; other site 167542001862 KMSKS motif; other site 167542001863 Domain of unknown function (DUF697); Region: DUF697; pfam05128 167542001864 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 167542001865 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 167542001866 metal binding site [ion binding]; metal-binding site 167542001867 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 167542001868 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 167542001869 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 167542001870 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 167542001871 ABC-ATPase subunit interface; other site 167542001872 dimer interface [polypeptide binding]; other site 167542001873 putative PBP binding regions; other site 167542001874 Domain of unknown function (DUF4336); Region: DUF4336; pfam14234 167542001875 Protein of unknown function (DUF760); Region: DUF760; pfam05542 167542001876 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 167542001877 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 167542001878 Catalytic site [active] 167542001879 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase; Region: menD; TIGR00173 167542001880 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 167542001881 dimer interface [polypeptide binding]; other site 167542001882 tetramer interface [polypeptide binding]; other site 167542001883 PYR/PP interface [polypeptide binding]; other site 167542001884 TPP binding site [chemical binding]; other site 167542001885 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 167542001886 TPP-binding site; other site 167542001887 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 167542001888 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 167542001889 substrate binding site [chemical binding]; other site 167542001890 oxyanion hole (OAH) forming residues; other site 167542001891 trimer interface [polypeptide binding]; other site 167542001892 glycogen synthase; Provisional; Region: glgA; PRK00654 167542001893 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 167542001894 ADP-binding pocket [chemical binding]; other site 167542001895 homodimer interface [polypeptide binding]; other site 167542001896 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 167542001897 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 167542001898 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 167542001899 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14360 167542001900 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 167542001901 Substrate binding site; other site 167542001902 Mg++ binding site; other site 167542001903 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 167542001904 active site 167542001905 substrate binding site [chemical binding]; other site 167542001906 CoA binding site [chemical binding]; other site 167542001907 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 167542001908 S-adenosylmethionine binding site [chemical binding]; other site 167542001909 S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; cl17711 167542001910 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 167542001911 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 167542001912 hinge; other site 167542001913 active site 167542001914 2-phosphosulfolactate phosphatase; Provisional; Region: PRK00886 167542001915 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 167542001916 nitrilase; Region: PLN02798 167542001917 putative active site [active] 167542001918 catalytic triad [active] 167542001919 dimer interface [polypeptide binding]; other site 167542001920 AMIN domain; Region: AMIN; pfam11741 167542001921 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 167542001922 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 167542001923 active site 167542001924 metal binding site [ion binding]; metal-binding site 167542001925 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 167542001926 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 167542001927 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 167542001928 substrate binding pocket [chemical binding]; other site 167542001929 chain length determination region; other site 167542001930 substrate-Mg2+ binding site; other site 167542001931 catalytic residues [active] 167542001932 aspartate-rich region 1; other site 167542001933 active site lid residues [active] 167542001934 aspartate-rich region 2; other site 167542001935 acetyl-CoA synthetase; Provisional; Region: PRK00174 167542001936 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 167542001937 active site 167542001938 CoA binding site [chemical binding]; other site 167542001939 acyl-activating enzyme (AAE) consensus motif; other site 167542001940 AMP binding site [chemical binding]; other site 167542001941 acetate binding site [chemical binding]; other site 167542001942 Protein of unknown function (DUF1350); Region: DUF1350; pfam07082 167542001943 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 167542001944 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 167542001945 active site 167542001946 catalytic site [active] 167542001947 substrate binding site [chemical binding]; other site 167542001948 GLTT repeat (6 copies); Region: GLTT; pfam01744 167542001949 GLTT repeat (6 copies); Region: GLTT; pfam01744 167542001950 Protein of unknown function; Region: DUF3721; pfam12518 167542001951 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 167542001952 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 167542001953 dimer interface [polypeptide binding]; other site 167542001954 motif 1; other site 167542001955 active site 167542001956 motif 2; other site 167542001957 motif 3; other site 167542001958 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 167542001959 anticodon binding site; other site 167542001960 Tryptophan-rich protein (DUF2389); Region: DUF2389; pfam09493 167542001961 chlorophyll a/b binding light-harvesting protein; Region: PS_antenn_a_b; TIGR03041 167542001962 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 167542001963 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 167542001964 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 167542001965 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 167542001966 N-terminal domain interface [polypeptide binding]; other site 167542001967 dimer interface [polypeptide binding]; other site 167542001968 substrate binding pocket (H-site) [chemical binding]; other site 167542001969 T5orf172 domain; Region: T5orf172; pfam10544 167542001970 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167542001971 short chain dehydrogenase; Provisional; Region: PRK07326 167542001972 NAD(P) binding site [chemical binding]; other site 167542001973 active site 167542001974 lycopene cyclase family protein; Region: carotene-cycl; TIGR01790 167542001975 lycopene cyclase; Region: lycopene_cycl; TIGR01789 167542001976 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167542001977 light-dependent protochlorophyllide reductase; Region: LPOR; TIGR01289 167542001978 NAD(P) binding site [chemical binding]; other site 167542001979 active site 167542001980 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 167542001981 Mechanosensitive ion channel; Region: MS_channel; pfam00924 167542001982 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 167542001983 catalytic triad [active] 167542001984 conserved cis-peptide bond; other site 167542001985 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 167542001986 metal binding site 2 [ion binding]; metal-binding site 167542001987 putative DNA binding helix; other site 167542001988 metal binding site 1 [ion binding]; metal-binding site 167542001989 dimer interface [polypeptide binding]; other site 167542001990 structural Zn2+ binding site [ion binding]; other site 167542001991 radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167 167542001992 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 167542001993 FeS/SAM binding site; other site 167542001994 Protein of unknown function (DUF3641); Region: DUF3641; pfam12345 167542001995 glucosylglycerol 3-phosphatase; Region: salt_tol_Pase; TIGR02399 167542001996 Glucosylglycerol-phosphate phosphatase (Salt_tol_Pase); Region: Salt_tol_Pase; pfam09506 167542001997 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 167542001998 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 167542001999 homodimer interface [polypeptide binding]; other site 167542002000 substrate-cofactor binding pocket; other site 167542002001 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167542002002 catalytic residue [active] 167542002003 Homoserine O-succinyltransferase; Region: HTS; pfam04204 167542002004 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 167542002005 conserved cys residue [active] 167542002006 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 167542002007 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 167542002008 Sulfate transporter family; Region: Sulfate_transp; pfam00916 167542002009 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 167542002010 FAD binding domain; Region: FAD_binding_4; pfam01565 167542002011 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 167542002012 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 167542002013 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 167542002014 putative active site [active] 167542002015 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 167542002016 putative active site [active] 167542002017 Protein of unknown function (DUF2811); Region: DUF2811; pfam10929 167542002018 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 167542002019 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 167542002020 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 167542002021 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 167542002022 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 167542002023 chloroplast protein import component, Tic20 family; Region: 3a0901s05TIC20; TIGR00994 167542002024 Protein of unknown function (DUF2839); Region: DUF2839; pfam10999 167542002025 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 167542002026 nudix motif; other site 167542002027 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 167542002028 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 167542002029 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 167542002030 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 167542002031 Methyltransferase domain; Region: Methyltransf_23; pfam13489 167542002032 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 167542002033 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 167542002034 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 167542002035 Ligand binding site; other site 167542002036 Putative Catalytic site; other site 167542002037 DXD motif; other site 167542002038 Protein of unknown function (DUF1662); Region: DUF1662; pfam07878 167542002039 ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent; Region: RTPR; TIGR02505 167542002040 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 167542002041 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 167542002042 S-adenosylmethionine binding site [chemical binding]; other site 167542002043 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 167542002044 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 167542002045 G1 box; other site 167542002046 putative GEF interaction site [polypeptide binding]; other site 167542002047 GTP/Mg2+ binding site [chemical binding]; other site 167542002048 Switch I region; other site 167542002049 G2 box; other site 167542002050 G3 box; other site 167542002051 Switch II region; other site 167542002052 G4 box; other site 167542002053 G5 box; other site 167542002054 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 167542002055 Protein of unknown function (DUF3353); Region: DUF3353; pfam11833 167542002056 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 167542002057 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 167542002058 dimerization interface [polypeptide binding]; other site 167542002059 domain crossover interface; other site 167542002060 redox-dependent activation switch; other site 167542002061 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 167542002062 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 167542002063 Walker A/P-loop; other site 167542002064 ATP binding site [chemical binding]; other site 167542002065 Q-loop/lid; other site 167542002066 ABC transporter signature motif; other site 167542002067 Walker B; other site 167542002068 D-loop; other site 167542002069 H-loop/switch region; other site 167542002070 Protein of unknown function (DUF3531); Region: DUF3531; pfam12049 167542002071 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 167542002072 Integral membrane protein DUF92; Region: DUF92; pfam01940 167542002073 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_3; cd01835 167542002074 active site 167542002075 catalytic triad [active] 167542002076 oxyanion hole [active] 167542002077 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 167542002078 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 167542002079 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 167542002080 Walker A/P-loop; other site 167542002081 ATP binding site [chemical binding]; other site 167542002082 Q-loop/lid; other site 167542002083 ABC transporter signature motif; other site 167542002084 Walker B; other site 167542002085 D-loop; other site 167542002086 H-loop/switch region; other site 167542002087 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 167542002088 aspartate aminotransferase; Provisional; Region: PRK05764 167542002089 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 167542002090 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167542002091 homodimer interface [polypeptide binding]; other site 167542002092 catalytic residue [active] 167542002093 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 167542002094 active site 167542002095 Fe-S cluster binding site [ion binding]; other site 167542002096 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 167542002097 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 167542002098 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 167542002099 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 167542002100 C-terminal peptidase (prc); Region: prc; TIGR00225 167542002101 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 167542002102 protein binding site [polypeptide binding]; other site 167542002103 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 167542002104 Catalytic dyad [active] 167542002105 quinolinate synthetase; Provisional; Region: PRK09375 167542002106 TIGR04168 family protein; Region: TIGR04168 167542002107 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 167542002108 Repair protein; Region: Repair_PSII; pfam04536 167542002109 Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636 167542002110 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 167542002111 active site 167542002112 dimer interface [polypeptide binding]; other site 167542002113 metal binding site [ion binding]; metal-binding site 167542002114 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 167542002115 ATP-grasp domain; Region: ATP-grasp; pfam02222 167542002116 lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407 167542002117 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 167542002118 inhibitor-cofactor binding pocket; inhibition site 167542002119 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167542002120 catalytic residue [active] 167542002121 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 167542002122 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 167542002123 substrate binding site; other site 167542002124 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 167542002125 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167542002126 NAD(P) binding site [chemical binding]; other site 167542002127 active site 167542002128 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 167542002129 extended (e) SDRs; Region: SDR_e; cd08946 167542002130 NAD(P) binding site [chemical binding]; other site 167542002131 active site 167542002132 substrate binding site [chemical binding]; other site 167542002133 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 167542002134 active site 167542002135 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 167542002136 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 167542002137 [2Fe-2S] cluster binding site [ion binding]; other site 167542002138 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 167542002139 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 167542002140 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 167542002141 Walker A/P-loop; other site 167542002142 ATP binding site [chemical binding]; other site 167542002143 Q-loop/lid; other site 167542002144 ABC transporter signature motif; other site 167542002145 Walker B; other site 167542002146 D-loop; other site 167542002147 H-loop/switch region; other site 167542002148 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 167542002149 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 167542002150 putative switch regulator; other site 167542002151 non-specific DNA interactions [nucleotide binding]; other site 167542002152 DNA binding site [nucleotide binding] 167542002153 sequence specific DNA binding site [nucleotide binding]; other site 167542002154 putative cAMP binding site [chemical binding]; other site 167542002155 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 167542002156 Ferritin-like domain; Region: Ferritin; pfam00210 167542002157 ferroxidase diiron center [ion binding]; other site 167542002158 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 167542002159 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 167542002160 Walker A/P-loop; other site 167542002161 ATP binding site [chemical binding]; other site 167542002162 Q-loop/lid; other site 167542002163 ABC transporter signature motif; other site 167542002164 Walker B; other site 167542002165 D-loop; other site 167542002166 H-loop/switch region; other site 167542002167 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 167542002168 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 167542002169 minor groove reading motif; other site 167542002170 helix-hairpin-helix signature motif; other site 167542002171 substrate binding pocket [chemical binding]; other site 167542002172 active site 167542002173 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 167542002174 NADH(P)-binding; Region: NAD_binding_10; pfam13460 167542002175 NAD(P) binding site [chemical binding]; other site 167542002176 putative active site [active] 167542002177 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 167542002178 trimer interface [polypeptide binding]; other site 167542002179 putative Zn binding site [ion binding]; other site 167542002180 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 167542002181 GSH binding site [chemical binding]; other site 167542002182 catalytic residues [active] 167542002183 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 167542002184 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 167542002185 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167542002186 NAD(P) binding site [chemical binding]; other site 167542002187 active site 167542002188 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 167542002189 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 167542002190 catalytic residues [active] 167542002191 Protein of unknown function (DUF3685); Region: DUF3685; pfam12452 167542002192 conjugal transfer protein TrbB; Provisional; Region: PRK13728; cl17283 167542002193 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996 167542002194 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 167542002195 Protein of unknown function (DUF1292); Region: DUF1292; cl01608 167542002196 Protein of unknown function (DUF3727); Region: DUF3727; pfam12527 167542002197 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 167542002198 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 167542002199 active site 167542002200 motif I; other site 167542002201 motif II; other site 167542002202 gamma-glutamyl kinase; Provisional; Region: PRK05429 167542002203 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 167542002204 nucleotide binding site [chemical binding]; other site 167542002205 homotetrameric interface [polypeptide binding]; other site 167542002206 putative phosphate binding site [ion binding]; other site 167542002207 putative allosteric binding site; other site 167542002208 PUA domain; Region: PUA; pfam01472 167542002209 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 167542002210 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 167542002211 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 167542002212 trimer interface [polypeptide binding]; other site 167542002213 active site 167542002214 UDP-GlcNAc binding site [chemical binding]; other site 167542002215 lipid binding site [chemical binding]; lipid-binding site 167542002216 tartrate dehydrogenase; Region: TTC; TIGR02089 167542002217 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 167542002218 Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029 167542002219 active site 167542002220 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 167542002221 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 167542002222 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 167542002223 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 167542002224 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 167542002225 Fructose-1,6-bisphosphate aldolase; Region: FBP_aldolase_I_a; cd00948 167542002226 active site 167542002227 intersubunit interface [polypeptide binding]; other site 167542002228 catalytic residue [active] 167542002229 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 167542002230 intersubunit interface [polypeptide binding]; other site 167542002231 active site 167542002232 zinc binding site [ion binding]; other site 167542002233 Na+ binding site [ion binding]; other site 167542002234 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 167542002235 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 167542002236 putative active site [active] 167542002237 catalytic triad [active] 167542002238 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 167542002239 Archaea-specific RecJ-like exonuclease, contains DnaJ-type Zn finger domain [DNA replication, recombination, and repair]; Region: COG1107 167542002240 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 167542002241 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 167542002242 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 167542002243 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 167542002244 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 167542002245 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 167542002246 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 167542002247 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 167542002248 Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547 167542002249 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 167542002250 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 167542002251 putative active site [active] 167542002252 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 167542002253 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 167542002254 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 167542002255 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862 167542002256 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 167542002257 ligand binding site; other site 167542002258 oligomer interface; other site 167542002259 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 167542002260 dimer interface [polypeptide binding]; other site 167542002261 N-terminal domain interface [polypeptide binding]; other site 167542002262 sulfate 1 binding site; other site 167542002263 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 167542002264 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 167542002265 tRNA; other site 167542002266 putative tRNA binding site [nucleotide binding]; other site 167542002267 putative NADP binding site [chemical binding]; other site 167542002268 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 167542002269 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 167542002270 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 167542002271 putative active site [active] 167542002272 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 167542002273 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 167542002274 substrate binding site [chemical binding]; other site 167542002275 hexamer interface [polypeptide binding]; other site 167542002276 metal binding site [ion binding]; metal-binding site 167542002277 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 167542002278 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 167542002279 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 167542002280 Walker A/P-loop; other site 167542002281 ATP binding site [chemical binding]; other site 167542002282 Q-loop/lid; other site 167542002283 ABC transporter signature motif; other site 167542002284 Walker B; other site 167542002285 D-loop; other site 167542002286 H-loop/switch region; other site 167542002287 Domain of unknown function (DUF309); Region: DUF309; pfam03745 167542002288 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 167542002289 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 167542002290 G1 box; other site 167542002291 putative GEF interaction site [polypeptide binding]; other site 167542002292 GTP/Mg2+ binding site [chemical binding]; other site 167542002293 Switch I region; other site 167542002294 G2 box; other site 167542002295 G3 box; other site 167542002296 Switch II region; other site 167542002297 G4 box; other site 167542002298 G5 box; other site 167542002299 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 167542002300 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 167542002301 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 167542002302 geranylgeranyl reductase; Region: ChlP; TIGR02028 167542002303 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 167542002304 Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092 167542002305 sulfite reductase subunit beta; Provisional; Region: PRK13504 167542002306 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 167542002307 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 167542002308 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 167542002309 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 167542002310 generic binding surface II; other site 167542002311 ssDNA binding site; other site 167542002312 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 167542002313 ATP binding site [chemical binding]; other site 167542002314 putative Mg++ binding site [ion binding]; other site 167542002315 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 167542002316 nucleotide binding region [chemical binding]; other site 167542002317 ATP-binding site [chemical binding]; other site 167542002318 elongation factor Ts; Reviewed; Region: tsf; PRK12332 167542002319 UBA/TS-N domain; Region: UBA; pfam00627 167542002320 Elongation factor TS; Region: EF_TS; pfam00889 167542002321 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 167542002322 rRNA interaction site [nucleotide binding]; other site 167542002323 S8 interaction site; other site 167542002324 putative laminin-1 binding site; other site 167542002325 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 167542002326 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 167542002327 Probable Catalytic site; other site 167542002328 metal-binding site 167542002329 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 167542002330 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 167542002331 Walker A/P-loop; other site 167542002332 ATP binding site [chemical binding]; other site 167542002333 Q-loop/lid; other site 167542002334 ABC transporter signature motif; other site 167542002335 Walker B; other site 167542002336 D-loop; other site 167542002337 H-loop/switch region; other site 167542002338 DevC protein; Region: devC; TIGR01185 167542002339 FtsX-like permease family; Region: FtsX; pfam02687 167542002340 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 167542002341 HlyD family secretion protein; Region: HlyD_3; pfam13437 167542002342 phycocyanobilin:ferredoxin oxidoreductase; Validated; Region: PRK02816 167542002343 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 167542002344 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 167542002345 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 167542002346 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 167542002347 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 167542002348 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 167542002349 Protein of unknown function (DUF3148); Region: DUF3148; pfam11347 167542002350 cell division protein; Validated; Region: ftsH; CHL00176 167542002351 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167542002352 Walker A motif; other site 167542002353 ATP binding site [chemical binding]; other site 167542002354 Walker B motif; other site 167542002355 arginine finger; other site 167542002356 Peptidase family M41; Region: Peptidase_M41; pfam01434 167542002357 Clp protease; Region: CLP_protease; pfam00574 167542002358 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 167542002359 oligomer interface [polypeptide binding]; other site 167542002360 active site residues [active] 167542002361 Thf1-like protein; Reviewed; Region: PRK13266 167542002362 photosystem II biogenesis protein Psp29; Region: PS_II_psb29; TIGR03060 167542002363 Predicted metal-binding protein (DUF2103); Region: DUF2103; cl01651 167542002364 DNA cytosine methylase; Provisional; Region: PRK10458 167542002365 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 167542002366 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 167542002367 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 167542002368 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 167542002369 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 167542002370 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 167542002371 ATP-dependent DNA ligase; Validated; Region: PRK09247 167542002372 Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897 167542002373 active site 167542002374 DNA binding site [nucleotide binding] 167542002375 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 167542002376 DNA binding site [nucleotide binding] 167542002377 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 167542002378 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 167542002379 ATP binding site [chemical binding]; other site 167542002380 putative Mg++ binding site [ion binding]; other site 167542002381 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 167542002382 nucleotide binding region [chemical binding]; other site 167542002383 ATP-binding site [chemical binding]; other site 167542002384 DEAD/H associated; Region: DEAD_assoc; pfam08494 167542002385 Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391 167542002386 putative active site [active] 167542002387 putative metal binding site [ion binding]; other site 167542002388 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14259 167542002389 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 167542002390 Walker A/P-loop; other site 167542002391 ATP binding site [chemical binding]; other site 167542002392 Q-loop/lid; other site 167542002393 ABC transporter signature motif; other site 167542002394 Walker B; other site 167542002395 D-loop; other site 167542002396 H-loop/switch region; other site 167542002397 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 167542002398 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 167542002399 dimer interface [polypeptide binding]; other site 167542002400 conserved gate region; other site 167542002401 putative PBP binding loops; other site 167542002402 ABC-ATPase subunit interface; other site 167542002403 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 167542002404 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 167542002405 dimer interface [polypeptide binding]; other site 167542002406 conserved gate region; other site 167542002407 putative PBP binding loops; other site 167542002408 ABC-ATPase subunit interface; other site 167542002409 Ion channel; Region: Ion_trans_2; pfam07885 167542002410 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 167542002411 TrkA-N domain; Region: TrkA_N; pfam02254 167542002412 TrkA-C domain; Region: TrkA_C; pfam02080 167542002413 Protein of unknown function (DUF1499); Region: DUF1499; pfam07386 167542002414 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 167542002415 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 167542002416 catalytic triad [active] 167542002417 C factor cell-cell signaling protein; Provisional; Region: PRK09009 167542002418 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 167542002419 NADP binding site [chemical binding]; other site 167542002420 homodimer interface [polypeptide binding]; other site 167542002421 active site 167542002422 Tryptophan-rich protein (DUF2389); Region: DUF2389; pfam09493 167542002423 Chlorophyll A-B binding protein; Region: Chloroa_b-bind; pfam00504 167542002424 putative high light inducible protein; Region: PHA02337 167542002425 putative high light inducible protein; Region: PHA02337 167542002426 putative high light inducible protein; Region: PHA02337 167542002427 putative high light inducible protein; Region: PHA02337 167542002428 L-asparaginase II; Region: Asparaginase_II; pfam06089 167542002429 Protein of unknown function (DUF1230); Region: DUF1230; pfam06799 167542002430 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 167542002431 Protein of unknown function (DUF3318); Region: DUF3318; pfam11780 167542002432 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 167542002433 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 167542002434 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 167542002435 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 167542002436 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 167542002437 ATP-grasp domain; Region: ATP-grasp_4; cl17255 167542002438 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 167542002439 IMP binding site; other site 167542002440 dimer interface [polypeptide binding]; other site 167542002441 interdomain contacts; other site 167542002442 partial ornithine binding site; other site 167542002443 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 167542002444 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 167542002445 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 167542002446 Walker A/P-loop; other site 167542002447 ATP binding site [chemical binding]; other site 167542002448 Q-loop/lid; other site 167542002449 ABC transporter signature motif; other site 167542002450 Walker B; other site 167542002451 D-loop; other site 167542002452 H-loop/switch region; other site 167542002453 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 167542002454 RNA binding surface [nucleotide binding]; other site 167542002455 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 167542002456 triosephosphate isomerase; Provisional; Region: PRK14565 167542002457 substrate binding site [chemical binding]; other site 167542002458 dimer interface [polypeptide binding]; other site 167542002459 catalytic triad [active] 167542002460 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 167542002461 dihydropteroate synthase; Region: DHPS; TIGR01496 167542002462 substrate binding pocket [chemical binding]; other site 167542002463 dimer interface [polypeptide binding]; other site 167542002464 inhibitor binding site; inhibition site 167542002465 magnesium chelatase subunit H; Provisional; Region: PRK12493 167542002466 Domain of unknown function (DUF3479); Region: DUF3479; pfam11965 167542002467 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 167542002468 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 167542002469 dihydrodipicolinate reductase; Provisional; Region: PRK00048 167542002470 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 167542002471 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 167542002472 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 167542002473 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 167542002474 Protein of unknown function (DUF2949); Region: DUF2949; pfam11165 167542002475 Protein of unknown function (DUF3038); Region: DUF3038; pfam11237 167542002476 Domain of unknown function (DUF4335); Region: DUF4335; pfam14233 167542002477 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 167542002478 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 167542002479 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 167542002480 ATP binding site [chemical binding]; other site 167542002481 putative Mg++ binding site [ion binding]; other site 167542002482 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 167542002483 nucleotide binding region [chemical binding]; other site 167542002484 ATP-binding site [chemical binding]; other site 167542002485 TRCF domain; Region: TRCF; pfam03461 167542002486 Integral membrane protein TerC family; Region: TerC; cl10468 167542002487 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 167542002488 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 167542002489 putative active site [active] 167542002490 substrate binding site [chemical binding]; other site 167542002491 putative cosubstrate binding site; other site 167542002492 catalytic site [active] 167542002493 Formyl transferase, C-terminal domain; Region: Formyl_trans_C; pfam02911 167542002494 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 167542002495 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 167542002496 Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047 167542002497 diiron binding motif [ion binding]; other site 167542002498 Protein of unknown function (DUF2996); Region: DUF2996; pfam11210 167542002499 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 167542002500 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 167542002501 RNB domain; Region: RNB; pfam00773 167542002502 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 167542002503 RNA binding site [nucleotide binding]; other site 167542002504 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 167542002505 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 167542002506 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 167542002507 similar to hypothetical protein 167542002508 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 167542002509 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 167542002510 motif II; other site 167542002511 ribosomal protein L32; Validated; Region: rpl32; CHL00152 167542002512 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 167542002513 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167542002514 Walker A motif; other site 167542002515 ATP binding site [chemical binding]; other site 167542002516 Walker B motif; other site 167542002517 arginine finger; other site 167542002518 Peptidase family M41; Region: Peptidase_M41; pfam01434 167542002519 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 167542002520 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 167542002521 dimer interface [polypeptide binding]; other site 167542002522 decamer (pentamer of dimers) interface [polypeptide binding]; other site 167542002523 catalytic triad [active] 167542002524 peroxidatic and resolving cysteines [active] 167542002525 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 167542002526 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 167542002527 homotrimer interface [polypeptide binding]; other site 167542002528 Walker A motif; other site 167542002529 GTP binding site [chemical binding]; other site 167542002530 Walker B motif; other site 167542002531 Protein of unknown function (DUF2930); Region: DUF2930; pfam11152 167542002532 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 167542002533 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 167542002534 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 167542002535 active site 167542002536 HIGH motif; other site 167542002537 KMSKS motif; other site 167542002538 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 167542002539 tRNA binding surface [nucleotide binding]; other site 167542002540 anticodon binding site; other site 167542002541 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 167542002542 RNB domain; Region: RNB; pfam00773 167542002543 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 167542002544 ribosomal protein L33; Region: rpl33; CHL00104 167542002545 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 167542002546 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 167542002547 putative tRNA-binding site [nucleotide binding]; other site 167542002548 B3/4 domain; Region: B3_4; pfam03483 167542002549 tRNA synthetase B5 domain; Region: B5; smart00874 167542002550 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 167542002551 dimer interface [polypeptide binding]; other site 167542002552 motif 1; other site 167542002553 motif 3; other site 167542002554 motif 2; other site 167542002555 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 167542002556 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 167542002557 HSP70 interaction site [polypeptide binding]; other site 167542002558 ATP adenylyltransferase (5',5'''-P-1,P-4-tetraphosphate phosphorylase II) [Nucleotide transport and metabolism]; Region: APA2; COG4360 167542002559 ATP adenylyltransferase; Region: ATP_transf; pfam09830 167542002560 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996 167542002561 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 167542002562 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 167542002563 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 167542002564 substrate binding pocket [chemical binding]; other site 167542002565 dimer interface [polypeptide binding]; other site 167542002566 inhibitor binding site; inhibition site 167542002567 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 167542002568 B12 binding site [chemical binding]; other site 167542002569 cobalt ligand [ion binding]; other site 167542002570 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 167542002571 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 167542002572 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 167542002573 homodimer interface [polypeptide binding]; other site 167542002574 substrate-cofactor binding pocket; other site 167542002575 catalytic residue [active] 167542002576 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 167542002577 CobN/Magnesium Chelatase; Region: CobN-Mg_chel; pfam02514 167542002578 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 167542002579 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 167542002580 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 167542002581 active site 167542002582 Flavodoxin domain; Region: Flavodoxin_5; cl17428 167542002583 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 167542002584 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 167542002585 GIY-YIG motif/motif A; other site 167542002586 active site 167542002587 catalytic site [active] 167542002588 putative DNA binding site [nucleotide binding]; other site 167542002589 metal binding site [ion binding]; metal-binding site 167542002590 UvrB/uvrC motif; Region: UVR; pfam02151 167542002591 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 167542002592 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 167542002593 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 167542002594 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 167542002595 active site 167542002596 (T/H)XGH motif; other site 167542002597 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 167542002598 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 167542002599 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 167542002600 Domain of unknown function (DUF1995); Region: DUF1995; pfam09353 167542002601 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 167542002602 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 167542002603 catalytic residue [active] 167542002604 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 167542002605 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 167542002606 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 167542002607 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 167542002608 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 167542002609 HIGH motif; other site 167542002610 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 167542002611 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 167542002612 active site 167542002613 KMSKS motif; other site 167542002614 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 167542002615 tRNA binding surface [nucleotide binding]; other site 167542002616 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14096 167542002617 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 167542002618 active site 167542002619 dimer interface [polypeptide binding]; other site 167542002620 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 167542002621 dimer interface [polypeptide binding]; other site 167542002622 active site 167542002623 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 167542002624 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 167542002625 active site 167542002626 substrate binding site [chemical binding]; other site 167542002627 cosubstrate binding site; other site 167542002628 catalytic site [active] 167542002629 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 167542002630 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 167542002631 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II/unknown domain fusion protein; Provisional; Region: PRK09319 167542002632 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 167542002633 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 167542002634 dimerization interface [polypeptide binding]; other site 167542002635 active site 167542002636 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 167542002637 active site 167542002638 Protein of unknown function (DUF3110); Region: DUF3110; pfam11360 167542002639 chaperone protein DnaJ; Provisional; Region: PRK14299 167542002640 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 167542002641 HSP70 interaction site [polypeptide binding]; other site 167542002642 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 167542002643 substrate binding site [polypeptide binding]; other site 167542002644 dimer interface [polypeptide binding]; other site 167542002645 molecular chaperone DnaK; Provisional; Region: PRK13410 167542002646 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 167542002647 nucleotide binding site [chemical binding]; other site 167542002648 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 167542002649 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 167542002650 catalytic loop [active] 167542002651 iron binding site [ion binding]; other site 167542002652 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 167542002653 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 167542002654 active site 167542002655 dimerization interface [polypeptide binding]; other site 167542002656 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 167542002657 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 167542002658 dimer interface [polypeptide binding]; other site 167542002659 motif 1; other site 167542002660 active site 167542002661 motif 2; other site 167542002662 motif 3; other site 167542002663 heat shock protein 90; Provisional; Region: PRK05218 167542002664 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 167542002665 ATP binding site [chemical binding]; other site 167542002666 Mg2+ binding site [ion binding]; other site 167542002667 G-X-G motif; other site 167542002668 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 167542002669 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 167542002670 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 167542002671 catalytic triad [active] 167542002672 Protein of unknown function (DUF2499); Region: DUF2499; pfam10693 167542002673 Protein of unknown function (DUF3593); Region: DUF3593; pfam12159 167542002674 photosystem I reaction center subunit PsaK; Region: PS_I_psaK; TIGR03049 167542002675 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 167542002676 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 167542002677 TPP-binding site; other site 167542002678 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 167542002679 PYR/PP interface [polypeptide binding]; other site 167542002680 dimer interface [polypeptide binding]; other site 167542002681 TPP binding site [chemical binding]; other site 167542002682 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 167542002683 threonine dehydratase; Reviewed; Region: PRK09224 167542002684 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 167542002685 tetramer interface [polypeptide binding]; other site 167542002686 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167542002687 catalytic residue [active] 167542002688 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 167542002689 putative Ile/Val binding site [chemical binding]; other site 167542002690 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 167542002691 putative Ile/Val binding site [chemical binding]; other site 167542002692 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 167542002693 YGGT family; Region: YGGT; pfam02325 167542002694 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 167542002695 putative metal binding site [ion binding]; other site 167542002696 pyruvate kinase; Provisional; Region: PRK06354 167542002697 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 167542002698 domain interfaces; other site 167542002699 active site 167542002700 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 167542002701 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 167542002702 FtsX-like permease family; Region: FtsX; pfam02687 167542002703 lipoprotein signal peptidase; Provisional; Region: PRK14792 167542002704 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 167542002705 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 167542002706 G1 box; other site 167542002707 GTP/Mg2+ binding site [chemical binding]; other site 167542002708 Switch I region; other site 167542002709 G2 box; other site 167542002710 Switch II region; other site 167542002711 G3 box; other site 167542002712 G4 box; other site 167542002713 Domain of unknown function (DUF697); Region: DUF697; pfam05128 167542002714 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 167542002715 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 167542002716 catalytic residue [active] 167542002717 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 167542002718 nucleoside/Zn binding site; other site 167542002719 dimer interface [polypeptide binding]; other site 167542002720 catalytic motif [active] 167542002721 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 167542002722 homodimer interface [polypeptide binding]; other site 167542002723 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167542002724 catalytic residue [active] 167542002725 glutamine synthetase, type I; Region: GlnA; TIGR00653 167542002726 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 167542002727 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 167542002728 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 167542002729 S-adenosylmethionine binding site [chemical binding]; other site 167542002730 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 167542002731 GUN4-like; Region: GUN4; pfam05419 167542002732 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 167542002733 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 167542002734 active site residue [active] 167542002735 photosystem II reaction center protein Psb28; Provisional; Region: PRK13612 167542002736 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 167542002737 Domain of unknown function DUF20; Region: UPF0118; pfam01594 167542002738 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 167542002739 Protein export membrane protein; Region: SecD_SecF; cl14618 167542002740 protein-export membrane protein SecD; Region: secD; TIGR01129 167542002741 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 167542002742 pyruvate dehydrogenase E1 component beta subunit; Validated; Region: odpB; CHL00144 167542002743 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 167542002744 alpha subunit interface [polypeptide binding]; other site 167542002745 TPP binding site [chemical binding]; other site 167542002746 heterodimer interface [polypeptide binding]; other site 167542002747 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 167542002748 Protein of unknown function (DUF3082); Region: DUF3082; pfam11282 167542002749 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK02534 167542002750 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 167542002751 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 167542002752 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 167542002753 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 167542002754 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 167542002755 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 167542002756 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 167542002757 Catalytic site [active] 167542002758 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 167542002759 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 167542002760 active site 167542002761 DNA binding site [nucleotide binding] 167542002762 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 167542002763 DNA primase; Validated; Region: dnaG; PRK05667 167542002764 CHC2 zinc finger; Region: zf-CHC2; pfam01807 167542002765 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 167542002766 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 167542002767 active site 167542002768 metal binding site [ion binding]; metal-binding site 167542002769 interdomain interaction site; other site 167542002770 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 167542002771 EamA-like transporter family; Region: EamA; pfam00892 167542002772 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 167542002773 RuvA N terminal domain; Region: RuvA_N; pfam01330 167542002774 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 167542002775 16S/18S rRNA binding site [nucleotide binding]; other site 167542002776 S13e-L30e interaction site [polypeptide binding]; other site 167542002777 25S rRNA binding site [nucleotide binding]; other site 167542002778 Protein of unknown function (DUF3464); Region: DUF3464; pfam11947 167542002779 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK07374 167542002780 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 167542002781 active site 167542002782 PHP Thumb interface [polypeptide binding]; other site 167542002783 metal binding site [ion binding]; metal-binding site 167542002784 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 167542002785 generic binding surface I; other site 167542002786 generic binding surface II; other site 167542002787 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 167542002788 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 167542002789 Domain of unknown function (DUF1816); Region: DUF1816; pfam08846 167542002790 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 167542002791 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 167542002792 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 167542002793 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cl00258 167542002794 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 167542002795 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 167542002796 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 167542002797 catalytic site [active] 167542002798 subunit interface [polypeptide binding]; other site 167542002799 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 167542002800 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 167542002801 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 167542002802 Protein of unknown function (DUF3288); Region: DUF3288; pfam11691 167542002803 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 167542002804 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 167542002805 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 167542002806 Walker A/P-loop; other site 167542002807 ATP binding site [chemical binding]; other site 167542002808 Q-loop/lid; other site 167542002809 ABC transporter signature motif; other site 167542002810 Walker B; other site 167542002811 D-loop; other site 167542002812 H-loop/switch region; other site 167542002813 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 167542002814 Bacitracin resistance protein BacA; Region: BacA; pfam02673 167542002815 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 167542002816 active site 167542002817 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK00192 167542002818 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 167542002819 active site 167542002820 motif I; other site 167542002821 motif II; other site 167542002822 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 167542002823 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 167542002824 active site 167542002825 homodimer interface [polypeptide binding]; other site 167542002826 catalytic site [active] 167542002827 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 167542002828 Protein of unknown function (DUF2862); Region: DUF2862; pfam11061 167542002829 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 167542002830 ATP-binding cassette domain of an uncharacterized transporter similar in sequence to NatA; Region: ABC_NatA_like; cd03267 167542002831 Walker A/P-loop; other site 167542002832 ATP binding site [chemical binding]; other site 167542002833 Q-loop/lid; other site 167542002834 ABC transporter signature motif; other site 167542002835 Walker B; other site 167542002836 D-loop; other site 167542002837 H-loop/switch region; other site 167542002838 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 167542002839 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 167542002840 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 167542002841 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 167542002842 Endomembrane protein 70; Region: EMP70; pfam02990 167542002843 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 167542002844 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 167542002845 active site 167542002846 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 167542002847 active site 167542002848 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 167542002849 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 167542002850 ski2-like helicase; Provisional; Region: PRK00254 167542002851 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 167542002852 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 167542002853 active site pocket [active] 167542002854 oxyanion hole [active] 167542002855 catalytic triad [active] 167542002856 active site nucleophile [active] 167542002857 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 167542002858 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 167542002859 Coenzyme A binding pocket [chemical binding]; other site 167542002860 Protein of unknown function (DUF3303); Region: DUF3303; pfam11746 167542002861 Protein of unknown function, DUF393; Region: DUF393; pfam04134 167542002862 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 167542002863 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 167542002864 aminopeptidase N; Provisional; Region: pepN; PRK14015 167542002865 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 167542002866 Zn binding site [ion binding]; other site 167542002867 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 167542002868 ATP-grasp domain; Region: ATP-grasp; pfam02222 167542002869 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 167542002870 catalytic residues [active] 167542002871 dimer interface [polypeptide binding]; other site 167542002872 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 167542002873 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 167542002874 FMN binding site [chemical binding]; other site 167542002875 active site 167542002876 catalytic residues [active] 167542002877 substrate binding site [chemical binding]; other site 167542002878 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 167542002879 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 167542002880 active site 167542002881 Restriction endonuclease; Region: Mrr_cat; pfam04471 167542002882 MAPEG family; Region: MAPEG; pfam01124 167542002883 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 167542002884 Protein of unknown function (DUF2839); Region: DUF2839; pfam10999 167542002885 Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862 167542002886 PAP_fibrillin; Region: PAP_fibrillin; pfam04755 167542002887 Protein chain release factor A [Translation, ribosomal structure and biogenesis]; Region: PrfA; COG0216 167542002888 Protein of unknown function (DUF1499); Region: DUF1499; pfam07386 167542002889 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 167542002890 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 167542002891 dimer interface [polypeptide binding]; other site 167542002892 putative PBP binding regions; other site 167542002893 ABC-ATPase subunit interface; other site 167542002894 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 167542002895 metal binding site 2 [ion binding]; metal-binding site 167542002896 putative DNA binding helix; other site 167542002897 metal binding site 1 [ion binding]; metal-binding site 167542002898 dimer interface [polypeptide binding]; other site 167542002899 structural Zn2+ binding site [ion binding]; other site 167542002900 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 167542002901 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 167542002902 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 167542002903 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 167542002904 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 167542002905 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 167542002906 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 167542002907 P-loop, Walker A motif; other site 167542002908 Base recognition motif; other site 167542002909 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 167542002910 PQQ-like domain; Region: PQQ_2; pfam13360 167542002911 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 167542002912 structural tetrad; other site 167542002913 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 167542002914 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 167542002915 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 167542002916 Guanosine kinase-like sugar kinases. Found in bacteria and archaea, the guanosine kinase-like group is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: Guanosine_kinase_like; cd01947 167542002917 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 167542002918 substrate binding site [chemical binding]; other site 167542002919 ATP binding site [chemical binding]; other site 167542002920 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 167542002921 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 167542002922 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 167542002923 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 167542002924 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 167542002925 dimer interface [polypeptide binding]; other site 167542002926 conserved gate region; other site 167542002927 putative PBP binding loops; other site 167542002928 ABC-ATPase subunit interface; other site 167542002929 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_20; cd08519 167542002930 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 167542002931 homoserine dehydrogenase; Provisional; Region: PRK06349 167542002932 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 167542002933 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 167542002934 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 167542002935 Fe-S metabolism associated domain; Region: SufE; cl00951 167542002936 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 167542002937 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 167542002938 active site 167542002939 putative DNA-binding cleft [nucleotide binding]; other site 167542002940 dimer interface [polypeptide binding]; other site 167542002941 Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081 167542002942 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 167542002943 Walker A/P-loop; other site 167542002944 ATP binding site [chemical binding]; other site 167542002945 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 167542002946 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 167542002947 cytochrome b6-f complex subunit PetG; Reviewed; Region: petG; PRK00665 167542002948 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 167542002949 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 167542002950 S-adenosylmethionine binding site [chemical binding]; other site 167542002951 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 167542002952 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 167542002953 putative active site [active] 167542002954 oxyanion strand; other site 167542002955 catalytic triad [active] 167542002956 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 167542002957 catalytic residues [active] 167542002958 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 167542002959 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 167542002960 active site 167542002961 DNA gyrase subunit A; Validated; Region: PRK05560 167542002962 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 167542002963 CAP-like domain; other site 167542002964 active site 167542002965 primary dimer interface [polypeptide binding]; other site 167542002966 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 167542002967 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 167542002968 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 167542002969 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 167542002970 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 167542002971 lycopene cyclase family protein; Region: carotene-cycl; TIGR01790 167542002972 lycopene cyclase; Region: lycopene_cycl; TIGR01789 167542002973 Uncharacterized conserved protein [Function unknown]; Region: COG1543 167542002974 N-terminal catalytic domain of alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792 167542002975 active site 167542002976 substrate binding site [chemical binding]; other site 167542002977 catalytic site [active] 167542002978 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 167542002979 2-isopropylmalate synthase; Validated; Region: PRK00915 167542002980 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 167542002981 active site 167542002982 catalytic residues [active] 167542002983 metal binding site [ion binding]; metal-binding site 167542002984 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 167542002985 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 167542002986 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 167542002987 Zn2+ binding site [ion binding]; other site 167542002988 Mg2+ binding site [ion binding]; other site 167542002989 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14186 167542002990 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 167542002991 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 167542002992 homodimer interface [polypeptide binding]; other site 167542002993 NADP binding site [chemical binding]; other site 167542002994 substrate binding site [chemical binding]; other site 167542002995 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 167542002996 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 167542002997 substrate binding pocket [chemical binding]; other site 167542002998 chain length determination region; other site 167542002999 substrate-Mg2+ binding site; other site 167542003000 catalytic residues [active] 167542003001 aspartate-rich region 1; other site 167542003002 active site lid residues [active] 167542003003 aspartate-rich region 2; other site 167542003004 Divergent PAP2 family; Region: DUF212; pfam02681 167542003005 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 167542003006 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 167542003007 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 167542003008 catalytic triad [active] 167542003009 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 167542003010 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 167542003011 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 167542003012 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 167542003013 ferredoxin--NADP+ reductase; Provisional; Region: PLN03116 167542003014 These ferredoxin reductases are related to the NADPH cytochrome p450 reductases (CYPOR), but lack the FAD-binding region connecting sub-domain. Ferredoxin-NADP+ reductase (FNR) is an FAD-containing enzyme that catalyzes the reversible electron transfer...; Region: CYPOR_like_FNR; cd06208 167542003015 dimerization interface [polypeptide binding]; other site 167542003016 FAD binding pocket [chemical binding]; other site 167542003017 FAD binding motif [chemical binding]; other site 167542003018 catalytic residues [active] 167542003019 NAD binding pocket [chemical binding]; other site 167542003020 phosphate binding motif [ion binding]; other site 167542003021 beta-alpha-beta structure motif; other site 167542003022 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 167542003023 hydrophobic ligand binding site; other site 167542003024 adaptive-response sensory kinase; Validated; Region: PRK09303 167542003025 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 167542003026 tetramer interface [polypeptide binding]; other site 167542003027 dimer interface [polypeptide binding]; other site 167542003028 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 167542003029 dimer interface [polypeptide binding]; other site 167542003030 phosphorylation site [posttranslational modification] 167542003031 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 167542003032 ATP binding site [chemical binding]; other site 167542003033 Mg2+ binding site [ion binding]; other site 167542003034 G-X-G motif; other site 167542003035 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02812 167542003036 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 167542003037 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 167542003038 active site 167542003039 4-alpha-glucanotransferase; Provisional; Region: PRK14508 167542003040 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 167542003041 non-specific DNA binding site [nucleotide binding]; other site 167542003042 salt bridge; other site 167542003043 sequence-specific DNA binding site [nucleotide binding]; other site 167542003044 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 167542003045 ABC1 family; Region: ABC1; cl17513 167542003046 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 167542003047 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 167542003048 catalytic residue [active] 167542003049 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 167542003050 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 167542003051 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 167542003052 PGAP1-like protein; Region: PGAP1; pfam07819 167542003053 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 167542003054 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 167542003055 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 167542003056 putative active site [active] 167542003057 metal binding site [ion binding]; metal-binding site 167542003058 Clp protease ATP binding subunit; Region: clpC; CHL00095 167542003059 Clp amino terminal domain; Region: Clp_N; pfam02861 167542003060 Clp amino terminal domain; Region: Clp_N; pfam02861 167542003061 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167542003062 Walker A motif; other site 167542003063 ATP binding site [chemical binding]; other site 167542003064 Walker B motif; other site 167542003065 arginine finger; other site 167542003066 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167542003067 Walker A motif; other site 167542003068 ATP binding site [chemical binding]; other site 167542003069 Walker B motif; other site 167542003070 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 167542003071 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 167542003072 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 167542003073 Coenzyme A binding pocket [chemical binding]; other site 167542003074 diaminopimelate decarboxylase; Region: lysA; TIGR01048 167542003075 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 167542003076 active site 167542003077 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 167542003078 substrate binding site [chemical binding]; other site 167542003079 catalytic residues [active] 167542003080 dimer interface [polypeptide binding]; other site 167542003081 TIGR00159 family protein; Region: TIGR00159 167542003082 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 167542003083 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14831 167542003084 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 167542003085 catalytic residue [active] 167542003086 putative FPP diphosphate binding site; other site 167542003087 putative FPP binding hydrophobic cleft; other site 167542003088 dimer interface [polypeptide binding]; other site 167542003089 putative IPP diphosphate binding site; other site 167542003090 biotin synthase; Region: bioB; TIGR00433 167542003091 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 167542003092 FeS/SAM binding site; other site 167542003093 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 167542003094 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 167542003095 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 167542003096 active site residue [active] 167542003097 lipoyl synthase; Provisional; Region: PRK12928 167542003098 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 167542003099 FeS/SAM binding site; other site 167542003100 recombination protein RecR; Reviewed; Region: recR; PRK00076 167542003101 RecR protein; Region: RecR; pfam02132 167542003102 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 167542003103 putative active site [active] 167542003104 putative metal-binding site [ion binding]; other site 167542003105 tetramer interface [polypeptide binding]; other site 167542003106 PsbP; Region: PsbP; pfam01789 167542003107 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 167542003108 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 167542003109 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 167542003110 Walker A/P-loop; other site 167542003111 ATP binding site [chemical binding]; other site 167542003112 Q-loop/lid; other site 167542003113 ABC transporter signature motif; other site 167542003114 Walker B; other site 167542003115 D-loop; other site 167542003116 H-loop/switch region; other site 167542003117 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 167542003118 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 167542003119 ATP binding site [chemical binding]; other site 167542003120 Mg++ binding site [ion binding]; other site 167542003121 motif III; other site 167542003122 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 167542003123 nucleotide binding region [chemical binding]; other site 167542003124 ATP-binding site [chemical binding]; other site 167542003125 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 167542003126 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 167542003127 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 167542003128 ATP binding site [chemical binding]; other site 167542003129 putative Mg++ binding site [ion binding]; other site 167542003130 Family description; Region: UvrD_C_2; pfam13538 167542003131 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 167542003132 Family description; Region: UvrD_C_2; pfam13538 167542003133 Phospholipid methyltransferase; Region: PEMT; cl17370 167542003134 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 167542003135 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 167542003136 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 167542003137 Protein of unknown function (DUF2488); Region: Ycf54; pfam10674 167542003138 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 167542003139 active site 167542003140 hydrophilic channel; other site 167542003141 dimerization interface [polypeptide binding]; other site 167542003142 catalytic residues [active] 167542003143 active site lid [active] 167542003144 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 167542003145 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 167542003146 putative acyl-acceptor binding pocket; other site 167542003147 BolA-like protein; Region: BolA; pfam01722 167542003148 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 167542003149 putative GSH binding site [chemical binding]; other site 167542003150 catalytic residues [active] 167542003151 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 167542003152 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 167542003153 active site 167542003154 intermolecular recognition site; other site 167542003155 dimerization interface [polypeptide binding]; other site 167542003156 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 167542003157 DNA binding site [nucleotide binding] 167542003158 carotene isomerase; Region: carot_isom; TIGR02730 167542003159 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 167542003160 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 167542003161 Glucose inhibited division protein A; Region: GIDA; pfam01134 167542003162 photosystem II protein Y; Reviewed; Region: pbsY; PRK13240 167542003163 Protein of unknown function (DUF3303); Region: DUF3303; pfam11746 167542003164 putative high light inducible protein; Region: PHA02337 167542003165 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 167542003166 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 167542003167 active site 167542003168 Autotransporter beta-domain; Region: Autotransporter; smart00869 167542003169 ski2-like helicase; Provisional; Region: PRK00254 167542003170 RmuC family; Region: RmuC; pfam02646 167542003171 PBP superfamily domain; Region: PBP_like_2; cl17296 167542003172 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 167542003173 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 167542003174 putative active site [active] 167542003175 PhoH-like protein; Region: PhoH; pfam02562 167542003176 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 167542003177 Protein of unknown function (DUF1651); Region: DUF1651; pfam07864 167542003178 Protein of unknown function (DUF1330); Region: DUF1330; pfam07045 167542003179 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 167542003180 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 167542003181 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 167542003182 Walker A/P-loop; other site 167542003183 ATP binding site [chemical binding]; other site 167542003184 Q-loop/lid; other site 167542003185 ABC transporter signature motif; other site 167542003186 Walker B; other site 167542003187 D-loop; other site 167542003188 H-loop/switch region; other site 167542003189 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 167542003190 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 167542003191 dimer interface [polypeptide binding]; other site 167542003192 conserved gate region; other site 167542003193 putative PBP binding loops; other site 167542003194 ABC-ATPase subunit interface; other site 167542003195 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 167542003196 dimer interface [polypeptide binding]; other site 167542003197 conserved gate region; other site 167542003198 putative PBP binding loops; other site 167542003199 ABC-ATPase subunit interface; other site 167542003200 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 167542003201 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 167542003202 substrate binding pocket [chemical binding]; other site 167542003203 membrane-bound complex binding site; other site 167542003204 hinge residues; other site 167542003205 PAP_fibrillin; Region: PAP_fibrillin; pfam04755 167542003206 Protein of unknown function (DUF1651); Region: DUF1651; pfam07864 167542003207 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 167542003208 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 167542003209 Chlorophyll A-B binding protein; Region: Chloroa_b-bind; cl02879 167542003210 Cupin domain; Region: Cupin_2; pfam07883 167542003211 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 167542003212 nucleotide binding pocket [chemical binding]; other site 167542003213 K-X-D-G motif; other site 167542003214 catalytic site [active] 167542003215 Protein of unknown function (DUF1651); Region: DUF1651; pfam07864 167542003216 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 167542003217 SURF4 family; Region: SURF4; pfam02077 167542003218 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 167542003219 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 167542003220 RNA binding surface [nucleotide binding]; other site 167542003221 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 167542003222 probable active site [active] 167542003223 Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862 167542003224 Predicted membrane protein [Function unknown]; Region: COG4244 167542003225 Predicted membrane protein (DUF2231); Region: DUF2231; pfam09990 167542003226 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 167542003227 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 167542003228 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 167542003229 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 167542003230 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 167542003231 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 167542003232 Subunit I/III interface [polypeptide binding]; other site 167542003233 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 167542003234 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 167542003235 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 167542003236 Hypothetical chloroplast protein Ycf34; Region: Ycf34; pfam10718 167542003237 Protein of unknown function (DUF2862); Region: DUF2862; pfam11061 167542003238 Protein of unknown function (DUF3303); Region: DUF3303; pfam11746 167542003239 cytochrome b559 subunit beta; Provisional; Region: psbF; PRK02561 167542003240 Methyltransferase domain; Region: Methyltransf_24; pfam13578 167542003241 Methyltransferase domain; Region: Methyltransf_23; pfam13489 167542003242 Methyltransferase domain; Region: Methyltransf_12; pfam08242 167542003243 Cyclic phosphodiesterase-like protein; Region: CPDase; pfam07823 167542003244 Uncharacterized conserved protein [Function unknown]; Region: COG1434 167542003245 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 167542003246 putative active site [active] 167542003247 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 167542003248 Na2 binding site [ion binding]; other site 167542003249 putative substrate binding site 1 [chemical binding]; other site 167542003250 Na binding site 1 [ion binding]; other site 167542003251 putative substrate binding site 2 [chemical binding]; other site 167542003252 Uncharacterized conserved protein [Function unknown]; Region: COG0397 167542003253 hypothetical protein; Validated; Region: PRK00029 167542003254 Protein of unknown function (DUF1651); Region: DUF1651; pfam07864 167542003255 putative high light inducible protein; Region: PHA02337 167542003256 GDP-fucose protein O-fucosyltransferase and related proteins; Region: O-FucT_like; cl16914 167542003257 GDP-Fucose binding site [chemical binding]; other site 167542003258 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 167542003259 Methyltransferase domain; Region: Methyltransf_23; pfam13489 167542003260 cupin fold metalloprotein, WbuC family; Region: cupin_WbuC; TIGR04366 167542003261 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 167542003262 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 167542003263 NADP-binding site; other site 167542003264 homotetramer interface [polypeptide binding]; other site 167542003265 substrate binding site [chemical binding]; other site 167542003266 homodimer interface [polypeptide binding]; other site 167542003267 active site 167542003268 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 167542003269 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 167542003270 inhibitor-cofactor binding pocket; inhibition site 167542003271 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167542003272 catalytic residue [active] 167542003273 GTP-binding protein YchF; Reviewed; Region: PRK09601 167542003274 YchF GTPase; Region: YchF; cd01900 167542003275 G1 box; other site 167542003276 GTP/Mg2+ binding site [chemical binding]; other site 167542003277 Switch I region; other site 167542003278 G2 box; other site 167542003279 Switch II region; other site 167542003280 G3 box; other site 167542003281 G4 box; other site 167542003282 G5 box; other site 167542003283 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 167542003284 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 167542003285 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 167542003286 HlyD family secretion protein; Region: HlyD_3; pfam13437 167542003287 DNA polymerase I; Provisional; Region: PRK05755 167542003288 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 167542003289 active site 167542003290 metal binding site 1 [ion binding]; metal-binding site 167542003291 putative 5' ssDNA interaction site; other site 167542003292 metal binding site 3; metal-binding site 167542003293 metal binding site 2 [ion binding]; metal-binding site 167542003294 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 167542003295 putative DNA binding site [nucleotide binding]; other site 167542003296 putative metal binding site [ion binding]; other site 167542003297 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 167542003298 active site 167542003299 catalytic site [active] 167542003300 substrate binding site [chemical binding]; other site 167542003301 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 167542003302 active site 167542003303 DNA binding site [nucleotide binding] 167542003304 catalytic site [active] 167542003305 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 167542003306 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 167542003307 active site 167542003308 HIGH motif; other site 167542003309 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 167542003310 KMSKS motif; other site 167542003311 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 167542003312 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 167542003313 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 167542003314 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 167542003315 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 167542003316 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 167542003317 FMN binding site [chemical binding]; other site 167542003318 dimer interface [polypeptide binding]; other site 167542003319 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 167542003320 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 167542003321 Serine hydrolase; Region: Ser_hydrolase; cl17834 167542003322 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 167542003323 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 167542003324 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 167542003325 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 167542003326 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 167542003327 ligand binding site [chemical binding]; other site 167542003328 homodimer interface [polypeptide binding]; other site 167542003329 NAD(P) binding site [chemical binding]; other site 167542003330 trimer interface B [polypeptide binding]; other site 167542003331 trimer interface A [polypeptide binding]; other site 167542003332 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 167542003333 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 167542003334 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 167542003335 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 167542003336 TRX domain, novel NADPH thioredoxin reductase (NTR) family; composed of fusion proteins found only in oxygenic photosynthetic organisms containing both TRX and NTR domains. The TRX domain functions as a protein disulfide reductase via the reversible...; Region: TRX_NTR; cd02949 167542003337 catalytic residues [active] 167542003338 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 167542003339 rRNA binding site [nucleotide binding]; other site 167542003340 predicted 30S ribosome binding site; other site 167542003341 Ycf39; Provisional; Region: ycf39; CHL00194 167542003342 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 167542003343 NAD(P) binding site [chemical binding]; other site 167542003344 putative active site [active] 167542003345 cytochrome b6-f complex subunit PetM; Reviewed; Region: petM; PRK11876 167542003346 hydrolase, alpha/beta fold family protein; Region: PLN02824 167542003347 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 167542003348 acetohydroxyacid synthase small subunit; Region: ilvH; CHL00100 167542003349 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 167542003350 putative valine binding site [chemical binding]; other site 167542003351 dimer interface [polypeptide binding]; other site 167542003352 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 167542003353 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 167542003354 active site 167542003355 photosystem I assembly protein Ycf4; Provisional; Region: PRK02542 167542003356 photosystem II protein D2; Region: psbD; CHL00004 167542003357 pheophytin binding site; other site 167542003358 chlorophyll binding site; other site 167542003359 quinone binding site; other site 167542003360 Fe binding site [ion binding]; other site 167542003361 Photosystem II protein; Region: PSII; cl08223 167542003362 photosystem II 44 kDa subunit reaction center protein (also called P6 protein, CP43), bacterial and chloroplast; Region: psbC; TIGR01153 167542003363 Maf-like protein; Region: Maf; pfam02545 167542003364 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 167542003365 active site 167542003366 dimer interface [polypeptide binding]; other site 167542003367 cobyric acid synthase; Provisional; Region: PRK00784 167542003368 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 167542003369 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 167542003370 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 167542003371 catalytic triad [active] 167542003372 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 167542003373 catalytic loop [active] 167542003374 iron binding site [ion binding]; other site 167542003375 Protein of unknown function (DUF1673); Region: DUF1673; pfam07895 167542003376 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 167542003377 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 167542003378 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 167542003379 Protein of unknown function (DUF3617); Region: DUF3617; pfam12276 167542003380 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 167542003381 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 167542003382 dimer interface [polypeptide binding]; other site 167542003383 motif 1; other site 167542003384 active site 167542003385 motif 2; other site 167542003386 motif 3; other site 167542003387 Domain of unknown function (DUF1824); Region: DUF1824; pfam08854 167542003388 Methyltransferase domain; Region: Methyltransf_11; pfam08241 167542003389 Protein of unknown function (DUF3386); Region: DUF3386; pfam11866 167542003390 chlorophyll a/b binding light-harvesting protein; Region: PS_antenn_a_b; TIGR03041 167542003391 flavodoxin FldA; Validated; Region: PRK09267 167542003392 AhpC/TSA antioxidant enzyme; Region: AhpC-TSA_2; pfam13911 167542003393 Uncharacterized conserved protein [Function unknown]; Region: COG4095 167542003394 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 167542003395 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 167542003396 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 167542003397 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 167542003398 putative ADP-binding pocket [chemical binding]; other site 167542003399 EamA-like transporter family; Region: EamA; pfam00892 167542003400 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 167542003401 EamA-like transporter family; Region: EamA; pfam00892 167542003402 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 167542003403 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 167542003404 tandem repeat interface [polypeptide binding]; other site 167542003405 oligomer interface [polypeptide binding]; other site 167542003406 active site residues [active] 167542003407 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 167542003408 homotrimer interaction site [polypeptide binding]; other site 167542003409 active site 167542003410 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 167542003411 Bacterial PH domain; Region: DUF304; pfam03703 167542003412 putative inner membrane protein translocase component YidC; Provisional; Region: PRK02654 167542003413 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 167542003414 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 167542003415 Ycf46; Provisional; Region: ycf46; CHL00195 167542003416 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167542003417 Walker A motif; other site 167542003418 ATP binding site [chemical binding]; other site 167542003419 Walker B motif; other site 167542003420 arginine finger; other site 167542003421 seryl-tRNA synthetase; Provisional; Region: PRK05431 167542003422 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 167542003423 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 167542003424 dimer interface [polypeptide binding]; other site 167542003425 active site 167542003426 motif 1; other site 167542003427 motif 2; other site 167542003428 motif 3; other site 167542003429 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 167542003430 active site 167542003431 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cd00136 167542003432 protein binding site [polypeptide binding]; other site 167542003433 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 167542003434 putative substrate binding region [chemical binding]; other site 167542003435 ribosomal protein S14; Region: rps14; CHL00074 167542003436 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 167542003437 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 167542003438 RNase E interface [polypeptide binding]; other site 167542003439 trimer interface [polypeptide binding]; other site 167542003440 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 167542003441 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 167542003442 RNase E interface [polypeptide binding]; other site 167542003443 trimer interface [polypeptide binding]; other site 167542003444 active site 167542003445 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 167542003446 putative nucleic acid binding region [nucleotide binding]; other site 167542003447 G-X-X-G motif; other site 167542003448 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 167542003449 RNA binding site [nucleotide binding]; other site 167542003450 domain interface; other site 167542003451 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 167542003452 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 167542003453 active site 167542003454 Predicted methyltransferases [General function prediction only]; Region: COG0313 167542003455 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 167542003456 putative SAM binding site [chemical binding]; other site 167542003457 putative homodimer interface [polypeptide binding]; other site 167542003458 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 167542003459 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 167542003460 NADP-binding site; other site 167542003461 homotetramer interface [polypeptide binding]; other site 167542003462 substrate binding site [chemical binding]; other site 167542003463 homodimer interface [polypeptide binding]; other site 167542003464 active site 167542003465 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 167542003466 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 167542003467 NADP binding site [chemical binding]; other site 167542003468 active site 167542003469 putative substrate binding site [chemical binding]; other site 167542003470 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 167542003471 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 167542003472 Substrate binding site; other site 167542003473 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 167542003474 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 167542003475 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 167542003476 putative NAD(P) binding site [chemical binding]; other site 167542003477 active site 167542003478 putative substrate binding site [chemical binding]; other site 167542003479 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 167542003480 DHHC palmitoyltransferase; Region: zf-DHHC; pfam01529 167542003481 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 167542003482 NAD(P) binding site [chemical binding]; other site 167542003483 homodimer interface [polypeptide binding]; other site 167542003484 substrate binding site [chemical binding]; other site 167542003485 active site 167542003486 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 167542003487 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 167542003488 Mg++ binding site [ion binding]; other site 167542003489 putative catalytic motif [active] 167542003490 putative substrate binding site [chemical binding]; other site 167542003491 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167542003492 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 167542003493 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 167542003494 active site 167542003495 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 167542003496 putative trimer interface [polypeptide binding]; other site 167542003497 putative active site [active] 167542003498 putative substrate binding site [chemical binding]; other site 167542003499 putative CoA binding site [chemical binding]; other site 167542003500 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 167542003501 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 167542003502 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 167542003503 Glycosyl transferases group 1; Region: Glycos_transf_1; pfam00534 167542003504 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 167542003505 putative ADP-binding pocket [chemical binding]; other site 167542003506 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 167542003507 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 167542003508 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 167542003509 putative ADP-binding pocket [chemical binding]; other site 167542003510 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 167542003511 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 167542003512 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 167542003513 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 167542003514 metal-binding site 167542003515 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 167542003516 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 167542003517 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 167542003518 SLBB domain; Region: SLBB; pfam10531 167542003519 polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007 167542003520 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 167542003521 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 167542003522 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 167542003523 active site 167542003524 catalytic residues [active] 167542003525 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 167542003526 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 167542003527 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 167542003528 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 167542003529 active site 167542003530 Methyltransferase domain; Region: Methyltransf_18; pfam12847 167542003531 Methyltransferase FkbM domain; Region: Methyltransf_21; pfam05050 167542003532 Glycosyltransferase family 10 (fucosyltransferase); Region: Glyco_transf_10; pfam00852 167542003533 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 167542003534 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 167542003535 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 167542003536 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 167542003537 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 167542003538 catalytic residue [active] 167542003539 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 167542003540 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 167542003541 NADP binding site [chemical binding]; other site 167542003542 active site 167542003543 putative substrate binding site [chemical binding]; other site 167542003544 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 167542003545 Uncharacterized conserved protein [Function unknown]; Region: COG3347 167542003546 GT2_BcbE_like is likely involved in the biosynthesis of the polysaccharide capsule; Region: GT2_BcE_like; cd04183 167542003547 Ligand binding site; other site 167542003548 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 167542003549 active site 167542003550 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 167542003551 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 167542003552 Ligand binding site; other site 167542003553 Putative Catalytic site; other site 167542003554 DXD motif; other site 167542003555 Uncharacterized hypothetical proteins similar to the catalytic domains of Phosphoinositide-specific phospholipaseand Glycerophosphodiester phosphodiesterases; Region: PI-PLCc_GDPD_SF_unchar2; cd08584 167542003556 putative active site [active] 167542003557 catalytic site [active] 167542003558 Predicted integral membrane protein [Function unknown]; Region: COG5542 167542003559 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 167542003560 active site 167542003561 HAD superfamily (subfamily IA) hydrolase, TIGR02253; Region: CTE7 167542003562 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 167542003563 motif II; other site 167542003564 Methyltransferase domain; Region: Methyltransf_23; pfam13489 167542003565 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 167542003566 S-adenosylmethionine binding site [chemical binding]; other site 167542003567 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 167542003568 Methyltransferase domain; Region: Methyltransf_23; pfam13489 167542003569 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 167542003570 S-adenosylmethionine binding site [chemical binding]; other site 167542003571 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 167542003572 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 167542003573 substrate binding site; other site 167542003574 tetramer interface; other site 167542003575 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 167542003576 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167542003577 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 167542003578 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167542003579 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 167542003580 NAD(P) binding site [chemical binding]; other site 167542003581 active site 167542003582 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 167542003583 This family is most closely related to the GT1 family of glycosyltransferases. wcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis; Region: GT1_wcfI_like; cd03825 167542003584 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 167542003585 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 167542003586 probable UDP-glucose 6-dehydrogenase; Region: PLN02353 167542003587 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 167542003588 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 167542003589 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 167542003590 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 167542003591 NAD binding site [chemical binding]; other site 167542003592 putative substrate binding site 2 [chemical binding]; other site 167542003593 putative substrate binding site 1 [chemical binding]; other site 167542003594 active site 167542003595 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 167542003596 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 167542003597 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 167542003598 Catalytic site [active] 167542003599 ornithine carbamoyltransferase; Provisional; Region: PRK00779 167542003600 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 167542003601 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 167542003602 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 167542003603 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167542003604 Walker A motif; other site 167542003605 ATP binding site [chemical binding]; other site 167542003606 Walker B motif; other site 167542003607 arginine finger; other site 167542003608 Peptidase family M41; Region: Peptidase_M41; pfam01434 167542003609 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 167542003610 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 167542003611 catalytic motif [active] 167542003612 Zn binding site [ion binding]; other site 167542003613 RibD C-terminal domain; Region: RibD_C; cl17279 167542003614 Protein of unknown function (DUF3122); Region: DUF3122; pfam11320 167542003615 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 167542003616 active site 167542003617 SAM binding site [chemical binding]; other site 167542003618 putative homodimer interface [polypeptide binding]; other site 167542003619 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 167542003620 precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; Region: CbiT; TIGR02469 167542003621 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02649 167542003622 ATP-NAD kinase; Region: NAD_kinase; pfam01513 167542003623 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 167542003624 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 167542003625 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 167542003626 dimer interface [polypeptide binding]; other site 167542003627 motif 1; other site 167542003628 active site 167542003629 motif 2; other site 167542003630 motif 3; other site 167542003631 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 167542003632 Protein of unknown function (DUF3611); Region: DUF3611; pfam12263 167542003633 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 167542003634 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 167542003635 active site 167542003636 Riboflavin kinase; Region: Flavokinase; smart00904 167542003637 thiamine-phosphate pyrophosphorylase; Provisional; Region: PRK02615 167542003638 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 167542003639 thiamine phosphate binding site [chemical binding]; other site 167542003640 active site 167542003641 pyrophosphate binding site [ion binding]; other site 167542003642 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 167542003643 thiS-thiF/thiG interaction site; other site 167542003644 AIR carboxylase; Region: AIRC; smart01001 167542003645 uncharacterized cyanobacterial protein, TIGR03792 family; Region: TIGR03792 167542003646 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 167542003647 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 167542003648 homotrimer interaction site [polypeptide binding]; other site 167542003649 zinc binding site [ion binding]; other site 167542003650 CDP-binding sites; other site 167542003651 GTPase Era; Reviewed; Region: era; PRK00089 167542003652 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 167542003653 G1 box; other site 167542003654 GTP/Mg2+ binding site [chemical binding]; other site 167542003655 Switch I region; other site 167542003656 G2 box; other site 167542003657 Switch II region; other site 167542003658 G3 box; other site 167542003659 G4 box; other site 167542003660 G5 box; other site 167542003661 KH domain; Region: KH_2; pfam07650 167542003662 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 167542003663 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 167542003664 PhoH-like protein; Region: PhoH; pfam02562 167542003665 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 167542003666 signal recognition particle protein; Provisional; Region: PRK10867 167542003667 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 167542003668 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 167542003669 GTP binding site [chemical binding]; other site 167542003670 Signal peptide binding domain; Region: SRP_SPB; pfam02978 167542003671 DnaJ domain; Region: DnaJ; pfam00226 167542003672 Protein of unknown function (DUF4101); Region: DUF4101; pfam13355 167542003673 pyruvate dehydrogenase E1 component alpha subunit; Reviewed; Region: odpA; CHL00149 167542003674 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 167542003675 tetramer interface [polypeptide binding]; other site 167542003676 TPP-binding site [chemical binding]; other site 167542003677 heterodimer interface [polypeptide binding]; other site 167542003678 phosphorylation loop region [posttranslational modification] 167542003679 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 167542003680 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 167542003681 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 167542003682 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 167542003683 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 167542003684 DNA binding residues [nucleotide binding] 167542003685 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 167542003686 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 167542003687 putative substrate binding site [chemical binding]; other site 167542003688 putative ATP binding site [chemical binding]; other site 167542003689 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 167542003690 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 167542003691 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 167542003692 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 167542003693 putative active site [active] 167542003694 catalytic triad [active] 167542003695 putative dimer interface [polypeptide binding]; other site 167542003696 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 167542003697 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 167542003698 Nickel-containing superoxide dismutase; Region: Sod_Ni; cl07609 167542003699 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 167542003700 Catalytic site [active] 167542003701 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 167542003702 active site 167542003703 ribulose/triose binding site [chemical binding]; other site 167542003704 phosphate binding site [ion binding]; other site 167542003705 substrate (anthranilate) binding pocket [chemical binding]; other site 167542003706 product (indole) binding pocket [chemical binding]; other site 167542003707 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 167542003708 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 167542003709 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 167542003710 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 167542003711 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 167542003712 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 167542003713 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 167542003714 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 167542003715 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 167542003716 hinge; other site 167542003717 active site 167542003718 acetylornithine aminotransferase; Provisional; Region: PRK02627 167542003719 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 167542003720 inhibitor-cofactor binding pocket; inhibition site 167542003721 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167542003722 catalytic residue [active] 167542003723 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 167542003724 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 167542003725 FAD binding domain; Region: FAD_binding_4; pfam01565 167542003726 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 167542003727 putative deaminase; Validated; Region: PRK06846 167542003728 active site 167542003729 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14333 167542003730 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 167542003731 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 167542003732 FeS/SAM binding site; other site 167542003733 TRAM domain; Region: TRAM; pfam01938 167542003734 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 167542003735 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 167542003736 ATP-grasp domain; Region: ATP-grasp_4; cl17255 167542003737 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 167542003738 cell division protein FtsZ; Validated; Region: PRK09330 167542003739 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 167542003740 nucleotide binding site [chemical binding]; other site 167542003741 SulA interaction site; other site 167542003742 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 167542003743 oligomerization interface [polypeptide binding]; other site 167542003744 active site 167542003745 metal binding site [ion binding]; metal-binding site 167542003746 coproporphyrinogen III oxidase; Provisional; Region: PRK07379 167542003747 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 167542003748 FeS/SAM binding site; other site 167542003749 HemN C-terminal domain; Region: HemN_C; pfam06969 167542003750 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 167542003751 putative active site [active] 167542003752 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 167542003753 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 167542003754 oligomer interface [polypeptide binding]; other site 167542003755 active site residues [active] 167542003756 Clp protease; Region: CLP_protease; pfam00574 167542003757 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 167542003758 oligomer interface [polypeptide binding]; other site 167542003759 active site residues [active] 167542003760 ketol-acid reductoisomerase; Provisional; Region: PRK05479 167542003761 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 167542003762 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 167542003763 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 167542003764 light-harvesting-like protein 3; Provisional; Region: PLN00014 167542003765 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 167542003766 IHF dimer interface [polypeptide binding]; other site 167542003767 IHF - DNA interface [nucleotide binding]; other site 167542003768 Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523 167542003769 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 167542003770 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 167542003771 active site 167542003772 catalytic site [active] 167542003773 MFS/sugar transport protein; Region: MFS_2; pfam13347 167542003774 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 167542003775 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 167542003776 Permease; Region: Permease; pfam02405 167542003777 Protein of unknown function (DUF3119); Region: DUF3119; pfam11317 167542003778 Protein of unknown function (DUF3086); Region: DUF3086; pfam11285 167542003779 membrane protein; Provisional; Region: PRK14419 167542003780 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 167542003781 active site 167542003782 dimer interface [polypeptide binding]; other site 167542003783 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 167542003784 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 167542003785 active site 167542003786 HIGH motif; other site 167542003787 dimer interface [polypeptide binding]; other site 167542003788 KMSKS motif; other site 167542003789 Domain of unknown function (DUF1825); Region: DUF1825; pfam08855 167542003790 multifunctional aminopeptidase A; Provisional; Region: PRK00913 167542003791 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 167542003792 interface (dimer of trimers) [polypeptide binding]; other site 167542003793 Substrate-binding/catalytic site; other site 167542003794 Zn-binding sites [ion binding]; other site 167542003795 Peptide methionine sulfoxide reductase; Region: PMSR; pfam01625 167542003796 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 167542003797 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 167542003798 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 167542003799 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 167542003800 active site 167542003801 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 167542003802 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 167542003803 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 167542003804 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 167542003805 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 167542003806 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 167542003807 Surface antigen; Region: Bac_surface_Ag; pfam01103 167542003808 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 167542003809 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 167542003810 ATP binding site [chemical binding]; other site 167542003811 active site 167542003812 substrate binding site [chemical binding]; other site 167542003813 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 167542003814 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 167542003815 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 167542003816 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 167542003817 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 167542003818 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 167542003819 dimerization interface [polypeptide binding]; other site 167542003820 PAS domain; Region: PAS; smart00091 167542003821 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 167542003822 dimer interface [polypeptide binding]; other site 167542003823 phosphorylation site [posttranslational modification] 167542003824 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 167542003825 ATP binding site [chemical binding]; other site 167542003826 Mg2+ binding site [ion binding]; other site 167542003827 G-X-G motif; other site 167542003828 circadian clock protein KaiC; Reviewed; Region: PRK09302 167542003829 KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124 167542003830 Walker A motif; other site 167542003831 ATP binding site [chemical binding]; other site 167542003832 Walker B motif; other site 167542003833 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 167542003834 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 167542003835 Walker A motif; other site 167542003836 Walker A motif; other site 167542003837 ATP binding site [chemical binding]; other site 167542003838 Walker B motif; other site 167542003839 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 167542003840 tetramer interface [polypeptide binding]; other site 167542003841 dimer interface [polypeptide binding]; other site 167542003842 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 167542003843 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 167542003844 Methyltransferase domain; Region: Methyltransf_12; pfam08242 167542003845 S-adenosylmethionine binding site [chemical binding]; other site 167542003846 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02755 167542003847 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 167542003848 RNA binding site [nucleotide binding]; other site 167542003849 active site 167542003850 Stage II sporulation protein; Region: SpoIID; pfam08486 167542003851 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 167542003852 ribonuclease Z; Region: RNase_Z; TIGR02651 167542003853 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 167542003854 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 167542003855 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 167542003856 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 167542003857 catalytic loop [active] 167542003858 iron binding site [ion binding]; other site 167542003859 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 167542003860 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 167542003861 S-adenosylmethionine binding site [chemical binding]; other site 167542003862 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 167542003863 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 167542003864 ligand binding site [chemical binding]; other site 167542003865 NAD binding site [chemical binding]; other site 167542003866 dimerization interface [polypeptide binding]; other site 167542003867 catalytic site [active] 167542003868 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 167542003869 putative L-serine binding site [chemical binding]; other site 167542003870 photosystem II S4 domain protein; Region: PS_II_S4; TIGR03069 167542003871 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 167542003872 RNA binding surface [nucleotide binding]; other site 167542003873 PPOX class probable FMN-dependent enzyme, alr4036 family; Region: PPOX_FMN_cyano; TIGR04026 167542003874 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxase_2; pfam12766 167542003875 DoxX; Region: DoxX; pfam07681 167542003876 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 167542003877 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 167542003878 nucleotide binding pocket [chemical binding]; other site 167542003879 K-X-D-G motif; other site 167542003880 catalytic site [active] 167542003881 short chain dehydrogenase; Provisional; Region: PRK06197 167542003882 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 167542003883 putative NAD(P) binding site [chemical binding]; other site 167542003884 active site 167542003885 Protein of unknown function; Region: DUF3721; pfam12518 167542003886 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02705 167542003887 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 167542003888 NAD binding site [chemical binding]; other site 167542003889 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 167542003890 Pirin-related protein [General function prediction only]; Region: COG1741 167542003891 Pirin; Region: Pirin; pfam02678 167542003892 Protein of unknown function (DUF1643); Region: DUF1643; pfam07799 167542003893 Predicted membrane protein (DUF2214); Region: DUF2214; pfam09980 167542003894 GAF domain; Region: GAF; pfam01590 167542003895 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 167542003896 flavoprotein, HI0933 family; Region: TIGR00275 167542003897 Protein of unknown function (DUF805); Region: DUF805; pfam05656 167542003898 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 167542003899 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 167542003900 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227 167542003901 NADP binding site [chemical binding]; other site 167542003902 putative substrate binding site [chemical binding]; other site 167542003903 active site 167542003904 Fatty acid desaturase; Region: FA_desaturase; pfam00487 167542003905 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 167542003906 putative di-iron ligands [ion binding]; other site 167542003907 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 167542003908 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 167542003909 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 167542003910 active site 167542003911 motif I; other site 167542003912 motif II; other site 167542003913 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 167542003914 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 167542003915 Fatty acid desaturase; Region: FA_desaturase; pfam00487 167542003916 putative di-iron ligands [ion binding]; other site 167542003917 Protein of unknown function (DUF938); Region: DUF938; pfam06080 167542003918 putative high light inducible protein; Region: PHA02337 167542003919 putative high light inducible protein; Region: PHA02337 167542003920 putative high light inducible protein; Region: PHA02337 167542003921 Predicted permeases [General function prediction only]; Region: COG0795 167542003922 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 167542003923 Protein of unknown function (DUF3764); Region: DUF3764; pfam12594 167542003924 Protein of unknown function (DUF2839); Region: DUF2839; pfam10999 167542003925 Domain of Unknown Function (DUF1543); Region: DUF1543; pfam07566 167542003926 Domain of Unknown Function (DUF1543); Region: DUF1543; pfam07566 167542003927 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 167542003928 MarR family; Region: MarR_2; cl17246 167542003929 putative high light inducible protein; Region: PHA02337 167542003930 putative high light inducible protein; Region: PHA02337 167542003931 HPP family; Region: HPP; pfam04982 167542003932 BCCT family transporter; Region: BCCT; pfam02028 167542003933 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 167542003934 EVE domain; Region: EVE; cl00728 167542003935 Protein of unknown function (DUF2811); Region: DUF2811; pfam10929 167542003936 Domain of unknown function (DUF1818); Region: DUF1818; pfam08848 167542003937 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 167542003938 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 167542003939 nucleotide binding site [chemical binding]; other site 167542003940 putative NEF/HSP70 interaction site [polypeptide binding]; other site 167542003941 SBD interface [polypeptide binding]; other site 167542003942 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 167542003943 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 167542003944 active site 167542003945 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 167542003946 phosphoglyceromutase; Provisional; Region: PRK05434 167542003947 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 167542003948 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 167542003949 ring oligomerisation interface [polypeptide binding]; other site 167542003950 ATP/Mg binding site [chemical binding]; other site 167542003951 stacking interactions; other site 167542003952 hinge regions; other site 167542003953 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 167542003954 oligomerisation interface [polypeptide binding]; other site 167542003955 mobile loop; other site 167542003956 roof hairpin; other site 167542003957 ATP synthase CF1 beta subunit; Region: atpB; CHL00060 167542003958 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 167542003959 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 167542003960 alpha subunit interaction interface [polypeptide binding]; other site 167542003961 Walker A motif; other site 167542003962 ATP binding site [chemical binding]; other site 167542003963 Walker B motif; other site 167542003964 inhibitor binding site; inhibition site 167542003965 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 167542003966 ATP synthase CF1 epsilon subunit; Region: atpE; CHL00063 167542003967 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 167542003968 gamma subunit interface [polypeptide binding]; other site 167542003969 epsilon subunit interface [polypeptide binding]; other site 167542003970 LBP interface [polypeptide binding]; other site 167542003971 hypothetical protein; Provisional; Region: PRK02724 167542003972 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 167542003973 proline aminopeptidase P II; Provisional; Region: PRK10879 167542003974 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 167542003975 active site 167542003976 Domain of unknown function DUF21; Region: DUF21; pfam01595 167542003977 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 167542003978 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 167542003979 G1 box; other site 167542003980 GTP/Mg2+ binding site [chemical binding]; other site 167542003981 G2 box; other site 167542003982 Switch I region; other site 167542003983 G3 box; other site 167542003984 Switch II region; other site 167542003985 G4 box; other site 167542003986 G5 box; other site 167542003987 Domain of unknown function (DUF697); Region: DUF697; pfam05128 167542003988 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 167542003989 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 167542003990 active site 167542003991 (T/H)XGH motif; other site 167542003992 NAD synthetase; Provisional; Region: PRK13981 167542003993 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 167542003994 multimer interface [polypeptide binding]; other site 167542003995 active site 167542003996 catalytic triad [active] 167542003997 protein interface 1 [polypeptide binding]; other site 167542003998 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 167542003999 homodimer interface [polypeptide binding]; other site 167542004000 NAD binding pocket [chemical binding]; other site 167542004001 ATP binding pocket [chemical binding]; other site 167542004002 Mg binding site [ion binding]; other site 167542004003 active-site loop [active] 167542004004 Protein of unknown function (DUF3326); Region: DUF3326; pfam11805 167542004005 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 167542004006 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 167542004007 core domain interface [polypeptide binding]; other site 167542004008 delta subunit interface [polypeptide binding]; other site 167542004009 epsilon subunit interface [polypeptide binding]; other site 167542004010 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 167542004011 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 167542004012 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 167542004013 beta subunit interaction interface [polypeptide binding]; other site 167542004014 Walker A motif; other site 167542004015 ATP binding site [chemical binding]; other site 167542004016 Walker B motif; other site 167542004017 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 167542004018 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13429 167542004019 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 167542004020 F0F1 ATP synthase subunit B; Validated; Region: PRK07352 167542004021 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 167542004022 F0F1 ATP synthase subunit B'; Validated; Region: PRK07353 167542004023 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 167542004024 ATP synthase CF0 C subunit; Region: atpH; CHL00061 167542004025 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 167542004026 ATP synthase CF0 A subunit; Region: atpI; CHL00046 167542004027 ATP synthase I chain; Region: ATP_synt_I; pfam03899 167542004028 Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098 167542004029 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 167542004030 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 167542004031 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 167542004032 ResB-like family; Region: ResB; pfam05140 167542004033 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 167542004034 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 167542004035 Nitrogen regulatory protein P-II; Region: P-II; smart00938 167542004036 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 167542004037 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 167542004038 RNA binding surface [nucleotide binding]; other site 167542004039 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 167542004040 adenylosuccinate lyase; Provisional; Region: PRK07380 167542004041 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 167542004042 tetramer interface [polypeptide binding]; other site 167542004043 active site 167542004044 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 167542004045 fumarate hydratase; Reviewed; Region: fumC; PRK00485 167542004046 Class II fumarases; Region: Fumarase_classII; cd01362 167542004047 active site 167542004048 tetramer interface [polypeptide binding]; other site 167542004049 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 167542004050 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 167542004051 ATP binding site [chemical binding]; other site 167542004052 putative Mg++ binding site [ion binding]; other site 167542004053 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 167542004054 nucleotide binding region [chemical binding]; other site 167542004055 ATP-binding site [chemical binding]; other site 167542004056 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 167542004057 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 167542004058 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 167542004059 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 167542004060 catalytic residue [active] 167542004061 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 167542004062 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 167542004063 S-adenosylmethionine binding site [chemical binding]; other site 167542004064 AAA domain; Region: AAA_26; pfam13500 167542004065 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 167542004066 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 167542004067 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 167542004068 inhibitor-cofactor binding pocket; inhibition site 167542004069 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167542004070 catalytic residue [active] 167542004071 Protein of unknown function (DUF3143); Region: DUF3143; pfam11341 167542004072 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 167542004073 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 167542004074 HSP70 interaction site [polypeptide binding]; other site 167542004075 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; cl17726 167542004076 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 167542004077 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 167542004078 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 167542004079 active site 167542004080 catalytic tetrad [active] 167542004081 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 167542004082 Protein of unknown function (DUF1257); Region: DUF1257; pfam06868 167542004083 Protein of unknown function (DUF2997); Region: DUF2997; pfam11211 167542004084 HEAT repeats; Region: HEAT_2; pfam13646 167542004085 HEAT repeats; Region: HEAT_2; pfam13646 167542004086 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14457 167542004087 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 167542004088 FeS/SAM binding site; other site 167542004089 DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597 167542004090 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 167542004091 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 167542004092 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 167542004093 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 167542004094 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 167542004095 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 167542004096 DNA binding site [nucleotide binding] 167542004097 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 167542004098 DNA-directed RNA polymerase subunit gamma; Provisional; Region: rpoC1; PRK02625 167542004099 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 167542004100 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 167542004101 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 167542004102 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 167542004103 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 167542004104 RPB1 interaction site [polypeptide binding]; other site 167542004105 RPB10 interaction site [polypeptide binding]; other site 167542004106 RPB11 interaction site [polypeptide binding]; other site 167542004107 RPB3 interaction site [polypeptide binding]; other site 167542004108 RPB12 interaction site [polypeptide binding]; other site 167542004109 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 167542004110 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 167542004111 active site 167542004112 ribosomal protein S20; Region: rps20; CHL00102 167542004113 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 167542004114 histidinol dehydrogenase; Region: hisD; TIGR00069 167542004115 NAD binding site [chemical binding]; other site 167542004116 dimerization interface [polypeptide binding]; other site 167542004117 product binding site; other site 167542004118 substrate binding site [chemical binding]; other site 167542004119 zinc binding site [ion binding]; other site 167542004120 catalytic residues [active] 167542004121 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 167542004122 tetramer (dimer of dimers) interface [polypeptide binding]; other site 167542004123 active site 167542004124 dimer interface [polypeptide binding]; other site 167542004125 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 167542004126 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 167542004127 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 167542004128 protein binding site [polypeptide binding]; other site 167542004129 hypothetical protein; Provisional; Region: PRK14646 167542004130 heptamer interface [polypeptide binding]; other site 167542004131 Sm1 motif; other site 167542004132 hexamer interface [polypeptide binding]; other site 167542004133 RNA binding site [nucleotide binding]; other site 167542004134 Sm2 motif; other site 167542004135 NusA N-terminal domain; Region: NusA_N; pfam08529 167542004136 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 167542004137 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 167542004138 RNA binding site [nucleotide binding]; other site 167542004139 homodimer interface [polypeptide binding]; other site 167542004140 NusA-like KH domain; Region: KH_5; pfam13184 167542004141 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 167542004142 G-X-X-G motif; other site 167542004143 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cl00189 167542004144 translation initiation factor IF-2; Validated; Region: infB; PRK05306 167542004145 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 167542004146 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 167542004147 G1 box; other site 167542004148 putative GEF interaction site [polypeptide binding]; other site 167542004149 GTP/Mg2+ binding site [chemical binding]; other site 167542004150 Switch I region; other site 167542004151 G2 box; other site 167542004152 G3 box; other site 167542004153 Switch II region; other site 167542004154 G4 box; other site 167542004155 G5 box; other site 167542004156 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 167542004157 Translation-initiation factor 2; Region: IF-2; pfam11987 167542004158 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 167542004159 Protein of unknown function (DUF3493); Region: DUF3493; pfam11998 167542004160 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 167542004161 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 167542004162 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 167542004163 Ligand binding site; other site 167542004164 Putative Catalytic site; other site 167542004165 DXD motif; other site 167542004166 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 167542004167 B12 binding site [chemical binding]; other site 167542004168 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 167542004169 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 167542004170 FeS/SAM binding site; other site 167542004171 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 167542004172 L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590 167542004173 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 167542004174 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167542004175 homodimer interface [polypeptide binding]; other site 167542004176 catalytic residue [active] 167542004177 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 167542004178 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 167542004179 homodimer interface [polypeptide binding]; other site 167542004180 oligonucleotide binding site [chemical binding]; other site 167542004181 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 167542004182 RNA/DNA hybrid binding site [nucleotide binding]; other site 167542004183 active site 167542004184 Protein of unknown function (DUF1997); Region: DUF1997; pfam09366 167542004185 prephenate dehydratase; Provisional; Region: PRK11898 167542004186 Prephenate dehydratase; Region: PDT; pfam00800 167542004187 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 167542004188 putative L-Phe binding site [chemical binding]; other site 167542004189 Methyltransferase domain; Region: Methyltransf_31; pfam13847 167542004190 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 167542004191 S-adenosylmethionine binding site [chemical binding]; other site 167542004192 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 167542004193 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 167542004194 elongation factor Tu; Reviewed; Region: PRK00049 167542004195 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 167542004196 G1 box; other site 167542004197 GEF interaction site [polypeptide binding]; other site 167542004198 GTP/Mg2+ binding site [chemical binding]; other site 167542004199 Switch I region; other site 167542004200 G2 box; other site 167542004201 G3 box; other site 167542004202 Switch II region; other site 167542004203 G4 box; other site 167542004204 G5 box; other site 167542004205 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 167542004206 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 167542004207 Antibiotic Binding Site [chemical binding]; other site 167542004208 elongation factor G; Reviewed; Region: PRK00007 167542004209 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 167542004210 G1 box; other site 167542004211 putative GEF interaction site [polypeptide binding]; other site 167542004212 GTP/Mg2+ binding site [chemical binding]; other site 167542004213 Switch I region; other site 167542004214 G2 box; other site 167542004215 G3 box; other site 167542004216 Switch II region; other site 167542004217 G4 box; other site 167542004218 G5 box; other site 167542004219 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 167542004220 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 167542004221 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 167542004222 30S ribosomal protein S7; Validated; Region: PRK05302 167542004223 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 167542004224 S17 interaction site [polypeptide binding]; other site 167542004225 S8 interaction site; other site 167542004226 16S rRNA interaction site [nucleotide binding]; other site 167542004227 streptomycin interaction site [chemical binding]; other site 167542004228 23S rRNA interaction site [nucleotide binding]; other site 167542004229 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 167542004230 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 167542004231 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 167542004232 active site 167542004233 dimer interface [polypeptide binding]; other site 167542004234 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 167542004235 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 167542004236 active site 167542004237 FMN binding site [chemical binding]; other site 167542004238 substrate binding site [chemical binding]; other site 167542004239 3Fe-4S cluster binding site [ion binding]; other site 167542004240 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 167542004241 domain interface; other site 167542004242 YCII-related domain; Region: YCII; cl00999 167542004243 lipoyl synthase; Provisional; Region: PRK05481 167542004244 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 167542004245 FeS/SAM binding site; other site 167542004246 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 167542004247 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 167542004248 catalytic residues [active] 167542004249 catalytic nucleophile [active] 167542004250 Presynaptic Site I dimer interface [polypeptide binding]; other site 167542004251 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 167542004252 Synaptic Flat tetramer interface [polypeptide binding]; other site 167542004253 Synaptic Site I dimer interface [polypeptide binding]; other site 167542004254 DNA binding site [nucleotide binding] 167542004255 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 167542004256 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 167542004257 NlpC/P60 family; Region: NLPC_P60; pfam00877 167542004258 photosystem I reaction center protein subunit XI; Provisional; Region: PRK00704 167542004259 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 167542004260 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 167542004261 Ligand binding site; other site 167542004262 Putative Catalytic site; other site 167542004263 DXD motif; other site 167542004264 photosystem I P700 chlorophyll a apoprotein A2; Provisional; Region: psaB; PRK13199 167542004265 photosystem I P700 chlorophyll a apoprotein A1; Provisional; Region: psaA; PRK13200 167542004266 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 167542004267 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 167542004268 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 167542004269 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 167542004270 active site 167542004271 SAM binding site [chemical binding]; other site 167542004272 homodimer interface [polypeptide binding]; other site 167542004273 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 167542004274 haloacid dehalogenase superfamily, subfamily IA hydrolase, TIGR01548; Region: HAD-SF-IA-hyp1 167542004275 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 167542004276 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 167542004277 alanine racemase; Reviewed; Region: alr; PRK00053 167542004278 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 167542004279 active site 167542004280 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 167542004281 dimer interface [polypeptide binding]; other site 167542004282 substrate binding site [chemical binding]; other site 167542004283 catalytic residues [active] 167542004284 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 167542004285 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 167542004286 active site 167542004287 peptide chain release factor 1; Validated; Region: prfA; PRK00591 167542004288 This domain is found in peptide chain release factors; Region: PCRF; smart00937 167542004289 RF-1 domain; Region: RF-1; pfam00472 167542004290 ribosomal protein L31; Validated; Region: rpl31; CHL00136 167542004291 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 167542004292 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 167542004293 23S rRNA interface [nucleotide binding]; other site 167542004294 L3 interface [polypeptide binding]; other site 167542004295 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 167542004296 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 167542004297 dimerization interface 3.5A [polypeptide binding]; other site 167542004298 active site 167542004299 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 167542004300 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 167542004301 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 167542004302 alphaNTD - beta interaction site [polypeptide binding]; other site 167542004303 alphaNTD homodimer interface [polypeptide binding]; other site 167542004304 alphaNTD - beta' interaction site [polypeptide binding]; other site 167542004305 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 167542004306 30S ribosomal protein S11; Validated; Region: PRK05309 167542004307 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 167542004308 30S ribosomal protein S13; Region: bact_S13; TIGR03631 167542004309 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 167542004310 adenylate kinase; Provisional; Region: PRK14531 167542004311 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 167542004312 AMP-binding site [chemical binding]; other site 167542004313 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 167542004314 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 167542004315 SecY translocase; Region: SecY; pfam00344 167542004316 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 167542004317 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 167542004318 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 167542004319 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 167542004320 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 167542004321 5S rRNA interface [nucleotide binding]; other site 167542004322 L27 interface [polypeptide binding]; other site 167542004323 23S rRNA interface [nucleotide binding]; other site 167542004324 L5 interface [polypeptide binding]; other site 167542004325 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 167542004326 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 167542004327 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 167542004328 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 167542004329 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 167542004330 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 167542004331 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 167542004332 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 167542004333 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 167542004334 RNA binding site [nucleotide binding]; other site 167542004335 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 167542004336 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 167542004337 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 167542004338 23S rRNA interface [nucleotide binding]; other site 167542004339 putative translocon interaction site; other site 167542004340 signal recognition particle (SRP54) interaction site; other site 167542004341 L23 interface [polypeptide binding]; other site 167542004342 trigger factor interaction site; other site 167542004343 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 167542004344 23S rRNA interface [nucleotide binding]; other site 167542004345 5S rRNA interface [nucleotide binding]; other site 167542004346 putative antibiotic binding site [chemical binding]; other site 167542004347 L25 interface [polypeptide binding]; other site 167542004348 L27 interface [polypeptide binding]; other site 167542004349 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 167542004350 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 167542004351 G-X-X-G motif; other site 167542004352 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 167542004353 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 167542004354 putative translocon binding site; other site 167542004355 protein-rRNA interface [nucleotide binding]; other site 167542004356 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 167542004357 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 167542004358 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 167542004359 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 167542004360 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 167542004361 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 167542004362 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 167542004363 NADH-quinone oxidoreductase cyanobacterial subunit N; Region: NdhN; pfam11909 167542004364 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 167542004365 Iron-Sulfur binding protein C terminal; Region: LdpA_C; pfam12617 167542004366 recombinase A; Provisional; Region: recA; PRK09354 167542004367 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 167542004368 hexamer interface [polypeptide binding]; other site 167542004369 Walker A motif; other site 167542004370 ATP binding site [chemical binding]; other site 167542004371 Walker B motif; other site 167542004372 putative high light inducible protein; Region: PHA02337 167542004373 putative high light inducible protein; Region: PHA02337 167542004374 putative high light inducible protein; Region: PHA02337 167542004375 putative high light inducible protein; Region: PHA02337 167542004376 Protein of unknown function (DUF2839); Region: DUF2839; pfam10999 167542004377 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 167542004378 arogenate dehydrogenase; Reviewed; Region: PRK07417 167542004379 prephenate dehydrogenase; Validated; Region: PRK08507 167542004380 C-3',4' desaturase CrtD; Region: desat_CrtD; TIGR02733 167542004381 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 167542004382 Phosphotransferase enzyme family; Region: APH; pfam01636 167542004383 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 167542004384 active site 167542004385 ATP binding site [chemical binding]; other site 167542004386 Domain of unknown function (DUF4308); Region: DUF4308; pfam14159 167542004387 hypothetical protein; Validated; Region: PRK07411 167542004388 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 167542004389 ATP binding site [chemical binding]; other site 167542004390 substrate interface [chemical binding]; other site 167542004391 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 167542004392 active site residue [active] 167542004393 hypothetical protein; Validated; Region: PRK07413 167542004394 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; pfam02572 167542004395 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 167542004396 Walker A motif; other site 167542004397 homodimer interface [polypeptide binding]; other site 167542004398 ATP binding site [chemical binding]; other site 167542004399 hydroxycobalamin binding site [chemical binding]; other site 167542004400 Walker B motif; other site 167542004401 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 167542004402 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 167542004403 Ligand Binding Site [chemical binding]; other site 167542004404 S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK02770 167542004405 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 167542004406 recombination protein F; Reviewed; Region: recF; PRK00064 167542004407 Q-loop/lid; other site 167542004408 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 167542004409 ABC transporter signature motif; other site 167542004410 Walker B; other site 167542004411 D-loop; other site 167542004412 H-loop/switch region; other site 167542004413 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 167542004414 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 167542004415 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 167542004416 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 167542004417 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 167542004418 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 167542004419 PsaD; Region: PsaD; pfam02531 167542004420 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 167542004421 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 167542004422 dimer interface [polypeptide binding]; other site 167542004423 phosphorylation site [posttranslational modification] 167542004424 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 167542004425 Domain of unknown function DUF59; Region: DUF59; pfam01883 167542004426 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 167542004427 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 167542004428 Walker A motif; other site 167542004429 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 167542004430 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 167542004431 Protein of unknown function (DUF3529); Region: DUF3529; pfam12046 167542004432 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 167542004433 catalytic site [active] 167542004434 putative active site [active] 167542004435 putative substrate binding site [chemical binding]; other site 167542004436 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370 167542004437 conserved hypothetical protein; Region: TIGR03492 167542004438 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 167542004439 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 167542004440 dimerization interface [polypeptide binding]; other site 167542004441 putative ATP binding site [chemical binding]; other site 167542004442 bifunctional pantoate ligase/cytidylate kinase; Provisional; Region: PRK13477 167542004443 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 167542004444 active site 167542004445 nucleotide binding site [chemical binding]; other site 167542004446 HIGH motif; other site 167542004447 KMSKS motif; other site 167542004448 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 167542004449 CMP-binding site; other site 167542004450 The sites determining sugar specificity; other site 167542004451 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 167542004452 Low molecular weight phosphatase family; Region: LMWPc; cd00115 167542004453 active site 167542004454 phycoerythrobilin:ferredoxin oxidoreductase; Provisional; Region: PRK13248 167542004455 dihydrobiliverdin:ferredoxin oxidoreductase; Provisional; Region: PRK13246 167542004456 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 167542004457 heme binding pocket [chemical binding]; other site 167542004458 heme ligand [chemical binding]; other site 167542004459 isocitrate dehydrogenase; Validated; Region: PRK07362 167542004460 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 167542004461 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 167542004462 Aldose 1-epimerase, similar to Synechocystis Slr1438; Region: Aldose_epim_Slr1438; cd09025 167542004463 active site 167542004464 catalytic residues [active] 167542004465 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 167542004466 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 167542004467 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 167542004468 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 167542004469 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 167542004470 homodimer interface [polypeptide binding]; other site 167542004471 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 167542004472 active site pocket [active] 167542004473 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 167542004474 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 167542004475 dimerization interface [polypeptide binding]; other site 167542004476 active site 167542004477 metal binding site [ion binding]; metal-binding site 167542004478 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 167542004479 dsRNA binding site [nucleotide binding]; other site 167542004480 Protein of unknown function (DUF3252); Region: DUF3252; pfam11623 167542004481 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 167542004482 RimM N-terminal domain; Region: RimM; pfam01782 167542004483 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 167542004484 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 167542004485 glutaminase active site [active] 167542004486 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 167542004487 dimer interface [polypeptide binding]; other site 167542004488 active site 167542004489 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 167542004490 dimer interface [polypeptide binding]; other site 167542004491 active site 167542004492 photosystem I subunit VII; Region: psaC; CHL00065 167542004493 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 167542004494 acyl carrier protein; Provisional; Region: acpP; PRK00982 167542004495 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 167542004496 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 167542004497 dimer interface [polypeptide binding]; other site 167542004498 active site 167542004499 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 167542004500 transketolase; Region: PLN02790 167542004501 TPP-binding site [chemical binding]; other site 167542004502 dimer interface [polypeptide binding]; other site 167542004503 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 167542004504 PYR/PP interface [polypeptide binding]; other site 167542004505 dimer interface [polypeptide binding]; other site 167542004506 TPP binding site [chemical binding]; other site 167542004507 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 167542004508 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 167542004509 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 167542004510 Protein of unknown function (DUF3188); Region: DUF3188; pfam11384 167542004511 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 167542004512 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 167542004513 metal binding site [ion binding]; metal-binding site 167542004514 dimer interface [polypeptide binding]; other site 167542004515 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 167542004516 binding surface 167542004517 TPR repeat; Region: TPR_11; pfam13414 167542004518 TPR motif; other site 167542004519 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 167542004520 binding surface 167542004521 TPR motif; other site 167542004522 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 167542004523 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167542004524 Walker A motif; other site 167542004525 ATP binding site [chemical binding]; other site 167542004526 Walker B motif; other site 167542004527 arginine finger; other site 167542004528 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 167542004529 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 167542004530 SmpB-tmRNA interface; other site 167542004531 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 167542004532 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 167542004533 dimer interface [polypeptide binding]; other site 167542004534 putative anticodon binding site; other site 167542004535 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 167542004536 motif 1; other site 167542004537 active site 167542004538 motif 2; other site 167542004539 motif 3; other site 167542004540 Ycf27; Reviewed; Region: orf27; CHL00148 167542004541 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 167542004542 active site 167542004543 phosphorylation site [posttranslational modification] 167542004544 intermolecular recognition site; other site 167542004545 dimerization interface [polypeptide binding]; other site 167542004546 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 167542004547 DNA binding site [nucleotide binding] 167542004548 rod shape-determining protein MreC; Provisional; Region: PRK13922 167542004549 rod shape-determining protein MreC; Region: MreC; pfam04085 167542004550 rod shape-determining protein MreB; Provisional; Region: PRK13927 167542004551 MreB and similar proteins; Region: MreB_like; cd10225 167542004552 nucleotide binding site [chemical binding]; other site 167542004553 Mg binding site [ion binding]; other site 167542004554 putative protofilament interaction site [polypeptide binding]; other site 167542004555 RodZ interaction site [polypeptide binding]; other site 167542004556 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 167542004557 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 167542004558 dimer interface [polypeptide binding]; other site 167542004559 ssDNA binding site [nucleotide binding]; other site 167542004560 tetramer (dimer of dimers) interface [polypeptide binding]; other site 167542004561 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 167542004562 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 167542004563 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 167542004564 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 167542004565 homotetramer interface [polypeptide binding]; other site 167542004566 ligand binding site [chemical binding]; other site 167542004567 catalytic site [active] 167542004568 NAD binding site [chemical binding]; other site 167542004569 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 167542004570 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 167542004571 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 167542004572 putative substrate binding site [chemical binding]; other site 167542004573 putative ATP binding site [chemical binding]; other site 167542004574 hydrolase, alpha/beta fold family protein; Region: PLN02824 167542004575 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 167542004576 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 167542004577 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 167542004578 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 167542004579 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 167542004580 Mg2+ transporter (mgtE); Region: mgtE; TIGR00400 167542004581 MgtE intracellular N domain; Region: MgtE_N; smart00924 167542004582 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 167542004583 Divalent cation transporter; Region: MgtE; pfam01769 167542004584 CrcB-like protein; Region: CRCB; pfam02537 167542004585 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 167542004586 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 167542004587 ATP binding site [chemical binding]; other site 167542004588 Mg2+ binding site [ion binding]; other site 167542004589 G-X-G motif; other site 167542004590 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 167542004591 anchoring element; other site 167542004592 dimer interface [polypeptide binding]; other site 167542004593 ATP binding site [chemical binding]; other site 167542004594 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 167542004595 active site 167542004596 putative metal-binding site [ion binding]; other site 167542004597 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 167542004598 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 167542004599 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 167542004600 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 167542004601 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 167542004602 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 167542004603 Predicted transcriptional regulators [Transcription]; Region: COG1725 167542004604 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 167542004605 DNA-binding site [nucleotide binding]; DNA binding site 167542004606 serine O-acetyltransferase; Region: cysE; TIGR01172 167542004607 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 167542004608 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 167542004609 trimer interface [polypeptide binding]; other site 167542004610 active site 167542004611 substrate binding site [chemical binding]; other site 167542004612 CoA binding site [chemical binding]; other site 167542004613 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12902 167542004614 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 167542004615 ATP binding site [chemical binding]; other site 167542004616 putative Mg++ binding site [ion binding]; other site 167542004617 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 167542004618 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 167542004619 Coenzyme A binding pocket [chemical binding]; other site 167542004620 SnoaL-like domain; Region: SnoaL_2; pfam12680 167542004621 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 167542004622 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 167542004623 NAD binding site [chemical binding]; other site 167542004624 homodimer interface [polypeptide binding]; other site 167542004625 active site 167542004626 substrate binding site [chemical binding]; other site 167542004627 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 167542004628 homopentamer interface [polypeptide binding]; other site 167542004629 active site 167542004630 photosystem II core protein PsbZ; Region: PS_II_psbZ; TIGR03043 167542004631 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 167542004632 MutS domain I; Region: MutS_I; pfam01624 167542004633 MutS domain II; Region: MutS_II; pfam05188 167542004634 MutS domain III; Region: MutS_III; pfam05192 167542004635 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 167542004636 Walker A/P-loop; other site 167542004637 ATP binding site [chemical binding]; other site 167542004638 Q-loop/lid; other site 167542004639 ABC transporter signature motif; other site 167542004640 Walker B; other site 167542004641 D-loop; other site 167542004642 H-loop/switch region; other site 167542004643 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 167542004644 Precorrin-8X methylmutase; Region: CbiC; pfam02570 167542004645 DNA polymerase III subunit delta; Validated; Region: PRK07452 167542004646 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 167542004647 aspartate kinase; Provisional; Region: PRK07431 167542004648 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 167542004649 putative nucleotide binding site [chemical binding]; other site 167542004650 putative catalytic residues [active] 167542004651 putative Mg ion binding site [ion binding]; other site 167542004652 putative aspartate binding site [chemical binding]; other site 167542004653 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 167542004654 putative allosteric regulatory site; other site 167542004655 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 167542004656 putative allosteric regulatory residue; other site 167542004657 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 167542004658 putative allosteric regulatory site; other site 167542004659 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 167542004660 excinuclease ABC subunit B; Provisional; Region: PRK05298 167542004661 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 167542004662 ATP binding site [chemical binding]; other site 167542004663 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 167542004664 putative Mg++ binding site [ion binding]; other site 167542004665 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 167542004666 nucleotide binding region [chemical binding]; other site 167542004667 ATP-binding site [chemical binding]; other site 167542004668 Ultra-violet resistance protein B; Region: UvrB; pfam12344 167542004669 UvrB/uvrC motif; Region: UVR; pfam02151 167542004670 Protein of unknown function (DUF561); Region: DUF561; pfam04481 167542004671 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 167542004672 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 167542004673 Ligand Binding Site [chemical binding]; other site 167542004674 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 167542004675 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 167542004676 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 167542004677 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 167542004678 dihydrodipicolinate synthase; Region: dapA; TIGR00674 167542004679 dimer interface [polypeptide binding]; other site 167542004680 active site 167542004681 catalytic residue [active] 167542004682 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 167542004683 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 167542004684 trigger factor; Provisional; Region: tig; PRK01490 167542004685 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 167542004686 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 167542004687 Clp protease; Region: CLP_protease; pfam00574 167542004688 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 167542004689 oligomer interface [polypeptide binding]; other site 167542004690 active site residues [active] 167542004691 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 167542004692 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 167542004693 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 167542004694 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167542004695 Walker A motif; other site 167542004696 ATP binding site [chemical binding]; other site 167542004697 Walker B motif; other site 167542004698 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 167542004699 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14948 167542004700 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167542004701 Walker A motif; other site 167542004702 ATP binding site [chemical binding]; other site 167542004703 Walker B motif; other site 167542004704 arginine finger; other site 167542004705 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 167542004706 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 167542004707 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 167542004708 DXD motif; other site 167542004709 Stage II sporulation protein; Region: SpoIID; pfam08486 167542004710 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 167542004711 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 167542004712 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 167542004713 23S rRNA binding site [nucleotide binding]; other site 167542004714 L21 binding site [polypeptide binding]; other site 167542004715 L13 binding site [polypeptide binding]; other site 167542004716 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 167542004717 binding surface 167542004718 TPR motif; other site 167542004719 TPR repeat; Region: TPR_11; pfam13414 167542004720 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 167542004721 ThiS interaction site; other site 167542004722 putative active site [active] 167542004723 tetramer interface [polypeptide binding]; other site 167542004724 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167542004725 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 167542004726 NAD(P) binding site [chemical binding]; other site 167542004727 active site 167542004728 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 167542004729 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 167542004730 glycine dehydrogenase; Provisional; Region: PRK05367 167542004731 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 167542004732 tetramer interface [polypeptide binding]; other site 167542004733 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167542004734 catalytic residue [active] 167542004735 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 167542004736 tetramer interface [polypeptide binding]; other site 167542004737 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167542004738 catalytic residue [active] 167542004739 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 167542004740 lipoyl attachment site [posttranslational modification]; other site 167542004741 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 167542004742 Aluminium resistance protein; Region: Alum_res; pfam06838 167542004743 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 167542004744 Fatty acid desaturase; Region: FA_desaturase; pfam00487 167542004745 Di-iron ligands [ion binding]; other site 167542004746 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 167542004747 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 167542004748 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 167542004749 replicative DNA helicase; Region: DnaB; TIGR00665 167542004750 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 167542004751 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 167542004752 Walker A motif; other site 167542004753 ATP binding site [chemical binding]; other site 167542004754 Walker B motif; other site 167542004755 DNA binding loops [nucleotide binding] 167542004756 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 167542004757 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 167542004758 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 167542004759 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 167542004760 Protein of unknown function (DUF98); Region: DUF98; pfam01947 167542004761 SprT-like family; Region: SprT-like; pfam10263 167542004762 SprT homologues; Region: SprT; cl01182 167542004763 DNA ligase; Provisional; Region: 30; PHA02587 167542004764 Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015 167542004765 active site 167542004766 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of kDNA ligase-like ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_kDNA_ligase_like; cd08041 167542004767 DNA binding site [nucleotide binding] 167542004768 Uncharacterized conserved protein [Function unknown]; Region: COG0398 167542004769 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 167542004770 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 167542004771 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 167542004772 active site 167542004773 HIGH motif; other site 167542004774 nucleotide binding site [chemical binding]; other site 167542004775 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 167542004776 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 167542004777 active site 167542004778 KMSKS motif; other site 167542004779 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 167542004780 tRNA binding surface [nucleotide binding]; other site 167542004781 anticodon binding site; other site 167542004782 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 167542004783 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 167542004784 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 167542004785 homodimer interface [polypeptide binding]; other site 167542004786 metal binding site [ion binding]; metal-binding site 167542004787 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 167542004788 homodimer interface [polypeptide binding]; other site 167542004789 active site 167542004790 putative chemical substrate binding site [chemical binding]; other site 167542004791 metal binding site [ion binding]; metal-binding site 167542004792 spermidine synthase; Provisional; Region: PRK00811 167542004793 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 167542004794 S-adenosylmethionine binding site [chemical binding]; other site 167542004795 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 167542004796 agmatinase; Region: agmatinase; TIGR01230 167542004797 putative active site [active] 167542004798 Mn binding site [ion binding]; other site 167542004799 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 167542004800 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 167542004801 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 167542004802 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 167542004803 dimer interface [polypeptide binding]; other site 167542004804 anticodon binding site; other site 167542004805 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 167542004806 homodimer interface [polypeptide binding]; other site 167542004807 motif 1; other site 167542004808 active site 167542004809 motif 2; other site 167542004810 GAD domain; Region: GAD; pfam02938 167542004811 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 167542004812 active site 167542004813 motif 3; other site 167542004814 CTP synthetase; Validated; Region: pyrG; PRK05380 167542004815 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 167542004816 Catalytic site [active] 167542004817 active site 167542004818 UTP binding site [chemical binding]; other site 167542004819 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 167542004820 active site 167542004821 putative oxyanion hole; other site 167542004822 catalytic triad [active] 167542004823 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 167542004824 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 167542004825 FeS/SAM binding site; other site 167542004826 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 167542004827 Ligand Binding Site [chemical binding]; other site 167542004828 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 167542004829 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 167542004830 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 167542004831 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 167542004832 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 167542004833 homodimer interface [polypeptide binding]; other site 167542004834 substrate-cofactor binding pocket; other site 167542004835 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167542004836 catalytic residue [active] 167542004837 diphthine synthase; Region: dph5; TIGR00522 167542004838 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 167542004839 active site 167542004840 SAM binding site [chemical binding]; other site 167542004841 homodimer interface [polypeptide binding]; other site 167542004842 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 167542004843 Major Facilitator Superfamily; Region: MFS_1; pfam07690 167542004844 putative substrate translocation pore; other site 167542004845 polyphosphate kinase; Provisional; Region: PRK05443 167542004846 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 167542004847 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 167542004848 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 167542004849 putative domain interface [polypeptide binding]; other site 167542004850 putative active site [active] 167542004851 catalytic site [active] 167542004852 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 167542004853 putative domain interface [polypeptide binding]; other site 167542004854 putative active site [active] 167542004855 catalytic site [active] 167542004856 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 167542004857 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 167542004858 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 167542004859 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 167542004860 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 167542004861 DNA binding residues [nucleotide binding] 167542004862 Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170 167542004863 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 167542004864 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 167542004865 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 167542004866 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 167542004867 substrate binding site [chemical binding]; other site 167542004868 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 167542004869 substrate binding site [chemical binding]; other site 167542004870 ligand binding site [chemical binding]; other site 167542004871 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 167542004872 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 167542004873 Cl- selectivity filter; other site 167542004874 Cl- binding residues [ion binding]; other site 167542004875 pore gating glutamate residue; other site 167542004876 dimer interface [polypeptide binding]; other site 167542004877 H+/Cl- coupling transport residue; other site 167542004878 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 167542004879 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 167542004880 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 167542004881 putative active site [active] 167542004882 putative substrate binding site [chemical binding]; other site 167542004883 putative cosubstrate binding site; other site 167542004884 catalytic site [active] 167542004885 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 167542004886 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 167542004887 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 167542004888 nucleotide binding site [chemical binding]; other site 167542004889 NEF interaction site [polypeptide binding]; other site 167542004890 SBD interface [polypeptide binding]; other site 167542004891 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 167542004892 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 167542004893 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 167542004894 shikimate binding site; other site 167542004895 NAD(P) binding site [chemical binding]; other site 167542004896 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 167542004897 argininosuccinate synthase; Provisional; Region: PRK13820 167542004898 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 167542004899 ANP binding site [chemical binding]; other site 167542004900 Substrate Binding Site II [chemical binding]; other site 167542004901 Substrate Binding Site I [chemical binding]; other site 167542004902 Protein of unknown function (DUF3134); Region: DUF3134; pfam11332 167542004903 phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445 167542004904 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 167542004905 Mg++ binding site [ion binding]; other site 167542004906 putative catalytic motif [active] 167542004907 putative substrate binding site [chemical binding]; other site 167542004908 sucrose-phosphate synthase, putative, glycosyltransferase domain; Region: sucr_P_syn_N; TIGR02472 167542004909 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 167542004910 putative ADP-binding pocket [chemical binding]; other site 167542004911 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 167542004912 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 167542004913 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 167542004914 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 167542004915 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 167542004916 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 167542004917 Walker A/P-loop; other site 167542004918 ATP binding site [chemical binding]; other site 167542004919 Q-loop/lid; other site 167542004920 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 167542004921 ABC transporter signature motif; other site 167542004922 Walker B; other site 167542004923 D-loop; other site 167542004924 H-loop/switch region; other site 167542004925 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 167542004926 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 167542004927 active site 167542004928 substrate binding site [chemical binding]; other site 167542004929 ATP binding site [chemical binding]; other site 167542004930 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 167542004931 threonine synthase; Reviewed; Region: PRK06721 167542004932 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 167542004933 homodimer interface [polypeptide binding]; other site 167542004934 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167542004935 catalytic residue [active]