-- dump date   	20140620_000410
-- class       	Genbank::CDS
-- table       	cds_note
-- id	note
YP_001013829.1	binds the polymerase to DNA and acts as a sliding clamp
YP_001013831.1	catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis
YP_001013832.1	Catalyzes first step of the de novo purine nucleotide biosynthetic pathway
YP_001013833.1	COG188 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit [DNA replication, recombination, and repair]
YP_001013834.1	COG5010 Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]
YP_001013835.1	COG1600 Uncharacterized Fe-S protein [Energy production and conversion]
YP_001013836.1	COG2928 Uncharacterized conserved protein [Function unknown]
YP_001013837.1	Regulates rRNA biosynthesis by transcriptional antitermination
YP_001013838.1	COG552 Signal recognition particle GTPase [Intracellular trafficking and secretion]
YP_001013839.1	COG2208 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]
YP_001013840.1	catalyzes the formation of arginine from (N-L-arginino)succinate
YP_001013842.1	COG42 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]
YP_001013843.1	COG229 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]
YP_001013844.1	with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor
YP_001013845.1	chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion
YP_001013847.1	COG1162 Predicted GTPases [General function prediction only]
YP_001013848.1	COG718 Uncharacterized protein conserved in bacteria [Function unknown]
YP_001013849.1	catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis
YP_001013850.1	COG773 UDP-N-acetylmuramate-alanine ligase [Cell envelope biogenesis, outer membrane]
YP_001013851.1	COG57 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]
YP_001013852.1	COG611 Thiamine monophosphate kinase [Coenzyme metabolism]
YP_001013853.1	COG652 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones]
YP_001013854.1	Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA
YP_001013855.1	COG511 Biotin carboxyl carrier protein [Lipid metabolism]
YP_001013856.1	catalyzes oxidation of 4-(phosphohydroxy)-L-threonine into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which decarboxylates to form 1-amino-3-(phosphohydroxy)propan-2-one (3-amino-2-oxopropyl phosphate)
YP_001013857.1	COG451 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]
YP_001013862.1	COG75 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]
YP_001013863.1	Catalyzes the methylation of C-1 in cobalt-precorrin-5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A
YP_001013864.1	contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway
YP_001013866.1	COG270 Site-specific DNA methylase [DNA replication, recombination, and repair]
YP_001013868.1	COG625 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
YP_001013872.1	COG5010 Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]
YP_001013873.1	COG2226 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]
YP_001013883.1	COG768 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]
YP_001013884.1	COG431 Predicted flavoprotein [General function prediction only]
YP_001013885.1	COG426 Uncharacterized flavoproteins [Energy production and conversion]
YP_001013886.1	COG426 Uncharacterized flavoproteins [Energy production and conversion]
YP_001013887.1	Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
YP_001013888.1	catalyzes the formation of agmatine from arginine in putrescine and spermidine biosynthesis
YP_001013889.1	catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate
YP_001013890.1	COG665 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]
YP_001013891.1	allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA
YP_001013892.1	catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis
YP_001013893.1	bifunctional arginine biosynthesis protein ArgJ; functions at the 1st and 5th steps in arginine biosynthesis; involved in synthesis of acetylglutamate from glutamate and acetyl-CoA and ornithine by transacetylation between acetylornithine and glutmate
YP_001013899.1	catalyzes the reaction of cyanate and bicarbonate to produce ammonia and carbon dioxide
YP_001013902.1	COG3914 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]
YP_001013905.1	COG1525 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]
YP_001013930.1	COG3651 Uncharacterized protein conserved in bacteria [Function unknown]
YP_001013931.1	COG652 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones]
YP_001013936.1	COG300 Short-chain dehydrogenases of various substrate specificities [General function prediction only]
YP_001013938.1	COG1192 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]
YP_001013939.1	COG2274 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]
YP_001013941.1	COG438 Glycosyltransferase [Cell envelope biogenesis, outer membrane]
YP_001013945.1	COG116 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]
YP_001013950.1	COG1196 Chromosome segregation ATPases [Cell division and chromosome partitioning]
YP_001013952.1	related to lipid A disaccharide synthetase
YP_001013953.1	an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism
YP_001013958.1	COG4178 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]
YP_001013960.1	COG537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]
YP_001013961.1	cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+)
YP_001013962.1	COG657 Esterase/lipase [Lipid metabolism]
YP_001013963.1	COG520 Selenocysteine lyase [Amino acid transport and metabolism]
YP_001013964.1	COG719 ABC-type transport system involved in Fe-S cluster assembly, permease component [Posttranslational modification, protein turnover, chaperones]
YP_001013965.1	COG396 ABC-type transport system involved in Fe-S cluster assembly, ATPase component [Posttranslational modification, protein turnover, chaperones]
YP_001013966.1	with SufCD activates cysteine desulfurase SufS
YP_001013968.1	COG3330 Uncharacterized protein conserved in bacteria [Function unknown]
YP_001013970.1	catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate
YP_001013971.1	COG2256 ATPase related to the helicase subunit of the Holliday junction resolvase [DNA replication, recombination, and repair]
YP_001013973.1	COG1225 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]
YP_001013974.1	COG1521  transcriptional regulator, homolog of Bvg accessory factor [Transcription]
YP_001013975.1	catalyzes the reduction of 3'-phosphoadenylyl sulfate into sulfite
YP_001013976.1	COG1252 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]
YP_001013977.1	COG471 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]
YP_001013979.1	COG168 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]
YP_001013980.1	COG569 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]
YP_001013981.1	distantly related to HSP70-fold metalloproteases; catalyzes hydrolysis of 1,6-anhydro bond of anyhydro-N-acetylmuramic acid (anhMurNAc) and phosphorylates anhMurNAc to produce N-acetyl-muramate-6-phosphate; involved in murein recycling
YP_001013986.1	COG488 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]
YP_001013987.1	COG265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
YP_001013991.1	COG1570 Exonuclease VII, large subunit [DNA replication, recombination, and repair]
YP_001013994.1	COG1295 Predicted membrane protein [Function unknown]
YP_001013995.1	COG483 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]
YP_001013996.1	COG1538 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]
YP_001013997.1	COG1625 Fe-S oxidoreductase, related to NifB/MoaA family [Energy production and conversion]
YP_001014000.1	COG29 Aspartate oxidase [Coenzyme metabolism]
YP_001014001.1	COG4243 Predicted membrane protein [Function unknown]
YP_001014002.1	Ycf7; cytochrome b6-f complex subunit 6; with PetG, PetM and PetN makes up the small subunit of the cytochrome b6-f complex; cytochrome b6-f mediates electron transfer between photosystem II and photosystem I
YP_001014005.1	COG3146 Uncharacterized protein conserved in bacteria [Function unknown]
YP_001014006.1	COG1985 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]
YP_001014007.1	COG720 6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism]
YP_001014008.1	catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis
YP_001014011.1	COG625 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
YP_001014014.1	associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock
YP_001014015.1	COG1472 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]
YP_001014016.1	COG1587 Uroporphyrinogen-III synthase [Coenzyme metabolism]
YP_001014017.1	COG5637 Predicted integral membrane protein [Function unknown]
YP_001014018.1	COG3349 Uncharacterized conserved protein [Function unknown]
YP_001014019.1	COG316 Uncharacterized conserved protein [Function unknown]
YP_001014021.1	COG1090 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]
YP_001014023.1	COG2214 DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]
YP_001014024.1	COG31 Cysteine synthase [Amino acid transport and metabolism]
YP_001014026.1	COG1807 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]
YP_001014027.1	conserved hypothetical protein in cyanobacteria
YP_001014028.1	COG1122 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]
YP_001014029.1	COG745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]
YP_001014030.1	catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA
YP_001014031.1	catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP)
YP_001014032.1	COG2217 Cation transport ATPase [Inorganic ion transport and metabolism]
YP_001014034.1	Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents
YP_001014035.1	COG745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]
YP_001014036.1	involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY
YP_001014037.2	FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs
YP_001014038.1	COG331 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]
YP_001014039.1	COG204 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]
YP_001014040.1	Inactive homolog of metal-dependent proteases; COG1214 Inactive homolog of metal-dependent proteases, molecular chaperone [Posttranslational modification, protein turnover, chaperones]
YP_001014042.1	COG617 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]
YP_001014044.1	COG1562 Phytoene/squalene synthetase [Lipid metabolism]
YP_001014045.1	COG3349 Uncharacterized conserved protein [Function unknown]
YP_001014048.1	COG583 Transcriptional regulator [Transcription]
YP_001014049.1	COG4094 Predicted membrane protein [Function unknown]
YP_001014050.1	Catalyzes the transfer of electrons from NADH to ubiquinone
YP_001014051.1	Shuttles electrons from NAD(P)H, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain
YP_001014052.1	COG1354 Uncharacterized conserved protein [Function unknown]
YP_001014053.1	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure an
YP_001014054.1	COG685 5,10-methylenetetrahydrofolate reductase [Amino acid transport and metabolism]
YP_001014055.1	COG2771 DNA-binding HTH domain-containing proteins [Transcription]
YP_001014057.1	COG2954 Uncharacterized protein conserved in bacteria [Function unknown]
YP_001014058.1	catalyzes the phosphorylation of NAD to NADP
YP_001014059.1	Catalyzes the transfer of electrons from NADH to quinone
YP_001014060.1	Catalyzes the transfer of electrons from NADH to quinone
YP_001014061.1	Catalyzes the transfer of electrons from NADH to quinone
YP_001014062.1	Catalyzes the transfer of electrons from NADH to quinone
YP_001014063.1	catalyzes the formation of citrate from acetyl-CoA and oxaloacetate
YP_001014066.1	COG607 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]
YP_001014067.1	catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate
YP_001014068.1	COG23 Translation initiation factor 1 (eIF-1/SUI1) and related proteins [Translation, ribosomal structure and biogenesis]
YP_001014069.1	COG529 Adenylylsulfate kinase and related kinases [Inorganic ion transport and metabolism]
YP_001014070.1	COG41 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]
YP_001014071.1	COG1820 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]
YP_001014072.1	catalyzes the formation of Mg-protoporphyrin IX methyl ester and S-adenosyl-L-homocysteine from Mg-protoporphyrin IX and S-adenosyl-L-methionine
YP_001014073.1	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]
YP_001014074.1	COG1104 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]
YP_001014075.1	COG275 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]
YP_001014076.1	shuttles electrons from NAD(P)H, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradien
YP_001014077.1	COG824 Predicted thioesterase [General function prediction only]
YP_001014078.1	COG318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]
YP_001014079.1	COG4948 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]
YP_001014080.1	catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate
YP_001014081.1	COG1169 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]
YP_001014082.1	catalyzes the second step in the glutathione biosynthesis pathway, where it synthesizes ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione
YP_001014083.1	COG695 Glutaredoxin and related proteins [Posttranslational modification, protein turnover, chaperones]
YP_001014085.1	recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1
YP_001014087.1	COG319 Predicted metal-dependent hydrolase [General function prediction only]
YP_001014088.1	COG818 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]
YP_001014089.1	COG512 Anthranilate/para-aminobenzoate synthases component II [Amino acid transport and metabolism / Coenzyme metabolism]
YP_001014090.1	COG79 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]
YP_001014091.1	catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase
YP_001014092.1	COG157 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]
YP_001014093.1	in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE
YP_001014095.1	COG3216 Uncharacterized protein conserved in bacteria [Function unknown]
YP_001014096.1	COG317 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]
YP_001014097.1	COG1123 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]
YP_001014098.1	COG564 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]
YP_001014099.1	essential GTPase; functions in ribosome assembly; binds a unique part of the 23S rRNA; interacts with ribosomal protein L25(Ctc)
YP_001014100.1	Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway
YP_001014102.1	COG707 UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell envelope biogenesis, outer membrane]
YP_001014103.1	COG79 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]
YP_001014104.1	catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors
YP_001014105.1	COG328 Ribonuclease HI [DNA replication, recombination, and repair]
YP_001014106.1	present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors
YP_001014107.1	binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit
YP_001014108.1	in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA
YP_001014109.1	binds directly to 23S ribosomal RNA
YP_001014110.1	Modulates Rho-dependent transcription termination
YP_001014112.1	COG714 MoxR-like ATPases [General function prediction only]
YP_001014113.1	enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis
YP_001014114.1	COG661 Predicted unusual protein kinase [General function prediction only]
YP_001014117.1	COG492 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]
YP_001014119.1	COG3329 Predicted permease [General function prediction only]
YP_001014120.1	COG659 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]
YP_001014121.1	COG2214 DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]
YP_001014122.1	catalyzes the formation of porphobilinogen from 5-aminolevulinate
YP_001014123.1	COG346 Lactoylglutathione lyase and related lyases [Amino acid transport and metabolism]
YP_001014124.1	COG1193 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]
YP_001014125.1	essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication
YP_001014128.1	COG5413 Uncharacterized integral membrane protein [Function unknown]
YP_001014129.1	COG435 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
YP_001014130.1	catalyzes the conversion of N-acetyl_L-aspartic acid (NAA) to aspartate and acetate
YP_001014133.1	catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis
YP_001014134.1	COG800 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]
YP_001014135.1	COG465 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]
YP_001014136.1	COG2046 ATP sulfurylase (sulfate adenylyltransferase) [Inorganic ion transport and metabolism]
YP_001014139.1	COG452 Phosphopantothenoylcysteine synthetase/decarboxylase [Coenzyme metabolism]
YP_001014141.1	catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis
YP_001014142.1	COG2094 3-methyladenine DNA glycosylase [DNA replication, recombination, and repair]
YP_001014143.1	allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; some Mycoplasma proteins contain an N-terminal fusion to an unknown domain
YP_001014144.1	COG3239 Fatty acid desaturase [Lipid metabolism]
YP_001014146.1	IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 1 subfamily; some organisms carry two different copies of this enzyme
YP_001014148.1	tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine
YP_001014149.1	COG526 Thiol-disulfide isomerase and thioredoxins [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]
YP_001014150.1	flavin dependent thymidylate synthase; ThyX; thymidylate synthase complementing protein; catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate; the enzyme from Mycobacterium tuberculosis forms homotetramers; uses FAD as a cofactor
YP_001014151.1	Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis
YP_001014152.1	COG2109 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]
YP_001014153.1	COG664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
YP_001014157.1	Enables the recycling of peptidyl-tRNAs produced at termination of translation
YP_001014158.1	COG1826 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]
YP_001014159.1	may be involved in regulating PSII assembly and/or stability
YP_001014160.1	4.8-kDa protein; may be involved in assembling and stabilizing of PSII dimers
YP_001014162.1	COG66 3-isopropylmalate dehydratase small subunit [Amino acid transport and metabolism]
YP_001014163.1	dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate
YP_001014164.1	COG1058 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]
YP_001014165.1	catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate
YP_001014168.1	COG728 Uncharacterized membrane protein,  virulence factor [General function prediction only]
YP_001014169.1	Regulatory factor involved in maltose metabolism
YP_001014170.1	COG4 Ammonia permease [Inorganic ion transport and metabolism]
YP_001014171.1	catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway
YP_001014172.1	COG2259 Predicted membrane protein [Function unknown]
YP_001014173.1	involved in de novo purine biosynthesis
YP_001014174.1	COG400 Predicted esterase [General function prediction only]
YP_001014177.1	COG642 Signal transduction histidine kinase [Signal transduction mechanisms]
YP_001014178.1	COG368 Cobalamin-5-phosphate synthase [Coenzyme metabolism]
YP_001014179.1	COG343 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]
YP_001014180.1	may be involved in binding plastoquinone and maintaining PSII dimers
YP_001014182.1	COG673 Predicted dehydrogenases and related proteins [General function prediction only]
YP_001014183.1	COG1253 Hemolysins and related proteins containing CBS domains [General function prediction only]
YP_001014184.1	involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate
YP_001014185.1	COG354 Predicted aminomethyltransferase related to GcvT [General function prediction only]
YP_001014186.1	COG2251 Predicted nuclease (RecB family) [General function prediction only]
YP_001014187.1	COG1109 Phosphomannomutase [Carbohydrate transport and metabolism]
YP_001014188.1	HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine
YP_001014189.1	COG3670 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]
YP_001014190.1	catalyzes the dehydration of D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate to 3-(imidazol-4-yl)-2-oxopropyl phosphate in histidine biosynthesis
YP_001014191.1	NADH-dependent; catalyzes a key regulatory step in fatty acid biosynthesis
YP_001014193.1	COG399 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]
YP_001014194.1	COG415 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]
YP_001014195.1	COG494 NTP pyrophosphohydrolases including oxidative damage repair enzymes [DNA replication, recombination, and repair / General function prediction only]
YP_001014196.1	COG801 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase [Coenzyme metabolism]
YP_001014197.1	COG1239 Mg-chelatase subunit ChlI [Coenzyme metabolism]
YP_001014198.1	COG1463 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]
YP_001014199.1	COG1127 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]
YP_001014200.1	COG391 Uncharacterized conserved protein [Function unknown]
YP_001014201.1	catalyzes the transfer of electrons from NADH to quinones
YP_001014202.1	The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen
YP_001014203.1	Catalyzes the transfer of electrons from NADH to quinone
YP_001014204.1	COG1773 Rubredoxin [Energy production and conversion]
YP_001014205.1	similar to Arabidopsis thaliana photosystem II assembly protein
YP_001014206.1	photosystem II reaction center subunit VI; associated with the reaction center of photosystem II
YP_001014207.1	may have a role in PSII core assembly, maintaining PSII dimers and donor side electron transfer
YP_001014208.1	may be involved in assembling and maintaining PSII complexes in the thylakoid membrane
YP_001014209.1	COG5 Purine nucleoside phosphorylase [Nucleotide transport and metabolism]
YP_001014210.1	COG1252 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]
YP_001014212.1	COG210 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]
YP_001014217.1	COG1413 FOG: HEAT repeat [Energy production and conversion]
YP_001014222.1	COG398 Uncharacterized conserved protein [Function unknown]
YP_001014223.1	COG451 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]
YP_001014224.1	COG451 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]
YP_001014228.1	COG1070 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]
YP_001014229.1	catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase
YP_001014230.1	COG546 Predicted phosphatases [General function prediction only]
YP_001014231.1	in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins
YP_001014232.1	COG1327 Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains [Transcription]
YP_001014233.1	Ycf8; may be involved in the formation and/or stabilization of PSII system complexes
YP_001014237.1	COG824 Predicted thioesterase [General function prediction only]
YP_001014238.1	COG2890 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]
YP_001014239.1	COG9  translation factor (SUA5) [Translation, ribosomal structure and biogenesis]
YP_001014241.1	works in conjunction with MinC and MinD to enable cell division at the midpoint of the long axis of the cell
YP_001014242.1	COG2894 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]
YP_001014244.1	COG1078 HD superfamily phosphohydrolases [General function prediction only]
YP_001014245.1	COG793 Periplasmic protease [Cell envelope biogenesis, outer membrane]
YP_001014246.1	electron transport protein
YP_001014247.1	PetD, with cytochrome b6, cytochrome F, and the Rieske protein, makes up the large subunit of the cytochrome b6-f complex; cytochrome b6-f mediates electron transfer between photosystem II and photosystem I
YP_001014249.1	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases
YP_001014250.1	Stabilizes the interaction between PsaC and the photosystem I core
YP_001014253.1	COG1012 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]
YP_001014255.1	COG398 Uncharacterized conserved protein [Function unknown]
YP_001014267.1	catalyzes the formation of 3-dehydroshikimate from 3-dehydroquinate in chorismate biosynthesis
YP_001014268.1	COG4445 Hydroxylase for synthesis of 2-methylthio-cis-ribozeatin in tRNA [Nucleotide transport and metabolism / Translation, ribosomal structure and biogenesis]
YP_001014269.1	COG2243 Precorrin-2 methylase [Coenzyme metabolism]
YP_001014270.1	COG42 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]
YP_001014272.1	EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains
YP_001014273.1	COG619 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]
YP_001014275.1	COG325 Predicted enzyme with a TIM-barrel fold [General function prediction only]
YP_001014276.1	COG1799 Uncharacterized protein conserved in bacteria [Function unknown]
YP_001014277.1	COG345 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]
YP_001014278.1	COG438 Glycosyltransferase [Cell envelope biogenesis, outer membrane]
YP_001014279.1	COG1381 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]
YP_001014280.1	COG274 Deoxyribose-phosphate aldolase [Nucleotide transport and metabolism]
YP_001014281.1	COG1544 Ribosome-associated protein Y (PSrp-1) [Translation, ribosomal structure and biogenesis]
YP_001014282.1	lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein
YP_001014283.1	COG1022 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]
YP_001014285.1	COG508 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion]
YP_001014286.1	Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step
YP_001014287.1	COG31 Cysteine synthase [Amino acid transport and metabolism]
YP_001014288.1	COG626 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]
YP_001014289.1	COG626 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]
YP_001014290.1	primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination
YP_001014291.1	COG759 Uncharacterized conserved protein [Function unknown]
YP_001014293.1	involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate
YP_001014294.1	COG520 Selenocysteine lyase [Amino acid transport and metabolism]
YP_001014300.1	COG694 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]
YP_001014301.1	malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate
YP_001014303.1	binds to the ribosome on the universally-conserved alpha-sarcin loop
YP_001014306.1	COG1173 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]
YP_001014307.1	COG566 rRNA methylases [Translation, ribosomal structure and biogenesis]
YP_001014309.1	COG144 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]
YP_001014310.1	COG382 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]
YP_001014312.1	catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase
YP_001014313.1	COG2226 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]
YP_001014315.1	chloroplast membrane-associated 30 kDa-like protein; COG1842 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]
YP_001014316.1	COG340 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]
YP_001014317.1	COG1136 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]
YP_001014318.1	catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity
YP_001014320.1	COG4241 Predicted membrane protein [Function unknown]
YP_001014321.1	COG2038 NaMN:DMB phosphoribosyltransferase [Coenzyme metabolism]
YP_001014323.1	catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine
YP_001014325.1	COG1845 Heme/copper-type cytochrome/quinol oxidase, subunit 3 [Energy production and conversion]
YP_001014326.1	COG843 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]
YP_001014327.1	COG1622 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]
YP_001014328.1	COG1612 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]
YP_001014329.1	converts protoheme IX and farnesyl diphosphate to heme O
YP_001014330.1	COG1131 ABC-type multidrug transport system, ATPase component [Defense mechanisms]
YP_001014333.1	60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is not essential for growth
YP_001014335.1	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]
YP_001014336.1	4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers
YP_001014337.1	COG1619 Uncharacterized proteins, homologs of microcin C7 resistance protein MccF [Defense mechanisms]
YP_001014338.1	UbiA prenyltransferase family catalyzes the transfer of a prenyl group to various acceptors with hydrophobic ring structures in the biosynthesis of respiratory quinones, hemes, chlorophylls, vitamin E, and shikonin
YP_001014339.1	COG248 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]
YP_001014341.1	COG2875 Precorrin-4 methylase [Coenzyme metabolism]
YP_001014342.1	transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein
YP_001014343.1	cytochrome f, with cytochrome b6, subunit IV, and the Rieske protein, makes up the large subunit of the cytochrome b6-f complex; cytochrome b6-f mediates electron transfer between photosystem II and photosystem I
YP_001014344.1	Rieske protein, with cytochrome b6, cytochrome f, and subunit IV, makes up the large subunit of the cytochrome b6-f complex; cytochrome b6-f mediates electron transfer between photosystem II and photosystem I
YP_001014346.1	COG805 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]
YP_001014348.1	COG1293 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]
YP_001014349.1	Essential for recycling GMP and indirectly, cGMP
YP_001014350.1	Enables the organization of the psaE and psaF subunits
YP_001014352.1	in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity
YP_001014354.1	COG4333 Uncharacterized protein conserved in bacteria [Function unknown]
YP_001014355.1	COG25 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]
YP_001014356.1	Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation
YP_001014358.1	this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site
YP_001014360.1	catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mnin Bacillus subtilis the protein in this cluster is considered non-essential
YP_001014362.1	COG857 BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]
YP_001014364.1	nucleotide binding property based on structural studies of Haemophilus influenzae crystallized protein in PDB Accession Number 1IN0 and NMR studies of Escherichia coli YajQ; the YajQ protein from Pseudomonas synringae appears to play a role in activation of bateriophage phi6 segment L transcription
YP_001014366.1	COG330 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]
YP_001014367.1	Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway
YP_001014368.1	COG708 Exonuclease III [DNA replication, recombination, and repair]
YP_001014371.1	COG1641 Uncharacterized conserved protein [Function unknown]
YP_001014373.1	COG1178 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]
YP_001014374.1	COG523  GTPases (G3E family) [General function prediction only]
YP_001014375.1	COG2154 Pterin-4a-carbinolamine dehydratase [Coenzyme metabolism]
YP_001014376.1	COG432 Uncharacterized conserved protein [Function unknown]
YP_001014377.1	COG2317 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]
YP_001014378.1	COG221 Inorganic pyrophosphatase [Energy production and conversion]
YP_001014379.1	transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis
YP_001014380.1	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this is the primary sigma factor of bacteria
YP_001014382.1	COG1198 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]
YP_001014384.1	catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate
YP_001014387.1	COG629 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]
YP_001014388.1	COG2099 Precorrin-6x reductase [Coenzyme metabolism]
YP_001014389.1	COG1324 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]
YP_001014390.1	COG524 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]
YP_001014391.1	catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis
YP_001014393.1	catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro)
YP_001014396.1	COG221 Inorganic pyrophosphatase [Energy production and conversion]
YP_001014397.1	COG1393 Arsenate reductase and related proteins, glutaredoxin family [Inorganic ion transport and metabolism]
YP_001014398.1	COG681 Signal peptidase I [Intracellular trafficking and secretion]
YP_001014399.1	COG406 Fructose-2,6-bisphosphatase [Carbohydrate transport and metabolism]
YP_001014400.1	COG1266 Predicted metal-dependent membrane protease [General function prediction only]
YP_001014402.1	COG768 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]
YP_001014403.1	COG176 Transaldolase [Carbohydrate transport and metabolism]
YP_001014404.1	COG644 Dehydrogenases (flavoproteins) [Energy production and conversion]
YP_001014405.1	Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs
YP_001014406.1	Catalyzes the phosphorylation of UMP to UDP
YP_001014407.1	COG2109 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]
YP_001014409.1	protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic
YP_001014410.1	catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit
YP_001014413.1	COG1098 Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]
YP_001014414.1	COG1402 Uncharacterized protein,  amidase [General function prediction only]
YP_001014416.1	COG5322 Predicted dehydrogenase [General function prediction only]
YP_001014417.1	catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein
YP_001014418.1	COG300 Short-chain dehydrogenases of various substrate specificities [General function prediction only]
YP_001014419.1	COG135 Phosphoribosylanthranilate isomerase [Amino acid transport and metabolism]
YP_001014420.1	COG1994 Zn-dependent proteases [General function prediction only]
YP_001014421.1	COG95 Lipoate-protein ligase A [Coenzyme metabolism]
YP_001014423.1	Converts chlorophyllide a into protochlorophyllide; light dependent
YP_001014424.1	light-independent; with chlN(bchN) and chlB(bchB) reduces ring D of protochlorophyllide to form chlorophyllide a in chlorophyll/bacteriochlorophyll production
YP_001014425.1	light-independent reduction of protochlorophyllide to form chlorophyllide a
YP_001014426.1	light-independent reduction of protochlorophyllide to form chlorophyllide a
YP_001014429.1	COG127 Xanthosine triphosphate pyrophosphatase [Nucleotide transport and metabolism]
YP_001014430.1	COG4577 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]
YP_001014431.1	type III RuBisCO; involved in carbon fixation
YP_001014432.1	COG4451 Ribulose bisphosphate carboxylase small subunit [Energy production and conversion]
YP_001014435.1	COG4576 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]
YP_001014436.1	COG4576 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]
YP_001014440.1	COG251  translation initiation inhibitor, yjgF family [Translation, ribosomal structure and biogenesis]
YP_001014441.1	COG491 Zn-dependent hydrolases, including glyoxylases [General function prediction only]
YP_001014442.1	short form of enzyme; requires HisZ for function; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms heteromultimer of HisG and HisZ
YP_001014443.1	COG1132 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]
YP_001014444.1	COG456 Acetyltransferases [General function prediction only]
YP_001014445.1	COG463 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]
YP_001014446.1	COG3222 Uncharacterized protein conserved in bacteria [Function unknown]
YP_001014447.1	binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.
YP_001014448.1	COG625 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
YP_001014449.1	COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]
YP_001014450.1	COG530 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]
YP_001014451.1	catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis
YP_001014454.1	catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis
YP_001014455.1	unknown function; YciI from Haemophilus influenzae has a crystal structure similar to a muconolactone isomerase, but does not seem to catalyze any of the reactions predicted from the sequence or structure similarity
YP_001014459.1	COG568 DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) [Transcription]
YP_001014461.1	catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribosyl)-ATP and the subsequent formation of 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamide from 1-(5-phosphoribosyl)-AMP in histidine biosynthesis
YP_001014463.1	COG714 MoxR-like ATPases [General function prediction only]
YP_001014464.1	participates in electron transfer in photosystem I
YP_001014465.1	COG451 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]
YP_001014466.1	catalyzes the formation of coproporphyrinogen from uroporphyrinogen III
YP_001014467.1	catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain
YP_001014468.1	COG2936 Predicted acyl esterases [General function prediction only]
YP_001014473.1	Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway
YP_001014474.1	COG1539 Dihydroneopterin aldolase [Coenzyme metabolism]
YP_001014476.1	COG339 Zn-dependent oligopeptidases [Amino acid transport and metabolism]
YP_001014477.1	shuttles electrons from NAD(P)H, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; subunit D, with NdhB and NdhF are core membrane components
YP_001014478.1	catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate
YP_001014479.1	COG837 Glucokinase [Carbohydrate transport and metabolism]
YP_001014480.1	catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr)
YP_001014481.1	catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
YP_001014484.1	COG803 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]
YP_001014485.1	COG1121 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]
YP_001014486.1	COG1108 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]
YP_001014489.1	COG681 Signal peptidase I [Intracellular trafficking and secretion]
YP_001014490.1	probable 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase; COG1165 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]
YP_001014491.1	catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA
YP_001014492.1	catalyzes the formation of alpha-1,4-glucan chains from ADP-glucose
YP_001014493.1	COG770 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]
YP_001014494.1	COG4121 Uncharacterized conserved protein [Function unknown]
YP_001014495.2	catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis
YP_001014496.1	Protein of unknown function DUF117, carboxy-lyase; COG43 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]
YP_001014497.1	catalyzes the formation of (2R)-3-sulfolactate from (2R)-2-phospho-3-sulfolactate
YP_001014498.1	COG388 Predicted amidohydrolase [General function prediction only]
YP_001014499.1	COG860 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]
YP_001014500.1	COG796 Glutamate racemase [Cell envelope biogenesis, outer membrane]
YP_001014501.1	COG142 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]
YP_001014502.1	COG637 Predicted phosphatase/phosphohexomutase [General function prediction only]
YP_001014503.1	COG365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]
YP_001014505.1	COG847 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]
YP_001014507.1	catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG
YP_001014508.1	COG1004 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]
YP_001014514.1	COG786 Na+/glutamate symporter [Amino acid transport and metabolism]
YP_001014516.1	COG625 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
YP_001014519.1	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]
YP_001014520.1	COG654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]
YP_001014522.1	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]
YP_001014523.1	COG668 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]
YP_001014524.1	COG1335 Amidases related to nicotinamidase [Secondary metabolites biosynthesis, transport, and catabolism]
YP_001014525.1	COG735 Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism]
YP_001014526.1	COG535 Predicted Fe-S oxidoreductases [General function prediction only]
YP_001014530.1	COG2873 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]
YP_001014531.1	COG1897 Homoserine trans-succinylase [Amino acid transport and metabolism]
YP_001014532.1	COG277 FAD/FMN-containing dehydrogenases [Energy production and conversion]
YP_001014533.1	COG2138 Uncharacterized conserved protein [Function unknown]
YP_001014535.1	COG2303 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]
YP_001014537.1	COG1807 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]
YP_001014542.1	COG4106 Trans-aconitate methyltransferase [General function prediction only]
YP_001014543.1	stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein
YP_001014545.1	becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers
YP_001014546.1	COG1122 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]
YP_001014548.1	in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase
YP_001014549.1	COG1836 Predicted membrane protein [Function unknown]
YP_001014550.1	COG2755 Lysophospholipase L1 and related esterases [Amino acid transport and metabolism]
YP_001014551.1	COG3639 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]
YP_001014552.1	COG3638 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]
YP_001014553.1	COG3221 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]
YP_001014554.1	COG436 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]
YP_001014556.1	COG1573 Uracil-DNA glycosylase [DNA replication, recombination, and repair]
YP_001014557.1	catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis
YP_001014559.1	COG793 Periplasmic protease [Cell envelope biogenesis, outer membrane]
YP_001014561.1	3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate
YP_001014564.1	COG1565 Uncharacterized conserved protein [Function unknown]
YP_001014565.1	catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis
YP_001014566.1	With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway
YP_001014585.1	COG2081 Predicted flavoproteins [General function prediction only]
YP_001014586.1	COG2259 Predicted membrane protein [Function unknown]
YP_001014589.1	COG628 Predicted permease [General function prediction only]
YP_001014590.1	PsbW; part of the phosystem II reaction center
YP_001014591.1	catalyzes the selenophosphate-dependent transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
YP_001014593.1	COG2172 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]
YP_001014595.1	COG2226 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]
YP_001014596.1	COG174 Glutamine synthetase [Amino acid transport and metabolism]
YP_001014597.1	COG75 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]
YP_001014598.1	COG590 Cytosine/adenosine deaminases [Nucleotide transport and metabolism / Translation, ribosomal structure and biogenesis]
YP_001014599.1	COG76 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]
YP_001014600.1	COG1100 GTPase SAR1 and related small G proteins [General function prediction only]
YP_001014601.1	lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis
YP_001014602.1	COG1268 Uncharacterized conserved protein [General function prediction only]
YP_001014604.1	COG612 Predicted Zn-dependent peptidases [General function prediction only]
YP_001014605.1	COG612 Predicted Zn-dependent peptidases [General function prediction only]
YP_001014606.1	catalyzes the reduction of biliverdin IX-alpha producing (3Z)-phycocyanobilin and oxidized ferredoxin
YP_001014607.1	COG845 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]
YP_001014608.1	COG577 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]
YP_001014609.1	COG1136 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]
YP_001014611.1	COG1216 Predicted glycosyltransferases [General function prediction only]
YP_001014612.1	one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit
YP_001014613.1	EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu
YP_001014615.1	catalyzes branch migration in Holliday junction intermediates
YP_001014616.1	COG2173 D-alanyl-D-alanine dipeptidase [Cell envelope biogenesis, outer membrane]
YP_001014617.2	hemoprotein; NADPH dependent; with the alpha subunit (a flavoprotein) catalyzes the reduction of sulfite to sulfide
YP_001014618.1	COG751 Glycyl-tRNA synthetase, beta subunit [Translation, ribosomal structure and biogenesis]
YP_001014619.1	COG644 Dehydrogenases (flavoproteins) [Energy production and conversion]
YP_001014621.1	COG1217 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]
YP_001014622.1	COG1547 Uncharacterized conserved protein [Function unknown]
YP_001014624.1	COG1137 ABC-type (unclassified) transport system, ATPase component [General function prediction only]
YP_001014625.1	COG795 Predicted permeases [General function prediction only]
YP_001014626.1	COG755 ABC-type transport system involved in cytochrome c biogenesis, permease component [Posttranslational modification, protein turnover, chaperones]
YP_001014627.1	COG36 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]
YP_001014628.1	type II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese
YP_001014629.1	catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins
YP_001014630.1	catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate
YP_001014631.1	catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate
YP_001014632.1	COG363 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]
YP_001014635.1	catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis
YP_001014637.1	COG35 Uracil phosphoribosyltransferase [Nucleotide transport and metabolism]
YP_001014639.1	COG523  GTPases (G3E family) [General function prediction only]
YP_001014641.1	COG1828 Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component [Nucleotide transport and metabolism]
YP_001014642.1	catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis
YP_001014643.1	COG3588 Fructose-1,6-bisphosphate aldolase [Carbohydrate transport and metabolism]
YP_001014644.1	COG673 Predicted dehydrogenases and related proteins [General function prediction only]
YP_001014646.1	catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits
YP_001014648.1	COG3954 Phosphoribulokinase [Energy production and conversion]
YP_001014649.1	catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis
YP_001014650.1	adds the O-linked and N-linked 3(R)-hydroxy fatty acids to the glucosamine disaccharide during lipid A biosynthesis
YP_001014651.1	catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis
YP_001014654.1	possible Holliday junction resolvase in Mycoplasmas and Bacillus subtilis; COG816 Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) [DNA replication, recombination, and repair]
YP_001014659.1	catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide
YP_001014660.1	COG451 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]
YP_001014661.1	COG558 Phosphatidylglycerophosphate synthase [Lipid metabolism]
YP_001014664.1	COG702 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]
YP_001014665.1	COG177 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]
YP_001014666.1	COG3842 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]
YP_001014667.1	COG1528 Ferritin-like protein [Inorganic ion transport and metabolism]
YP_001014669.1	COG664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
YP_001014672.1	COG1119 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]
YP_001014673.1	COG4638 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]
YP_001014676.1	COG1087 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]
YP_001014678.1	COG1898 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]
YP_001014679.1	COG1091 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]
YP_001014680.1	COG1088 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]
YP_001014681.1	COG381 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]
YP_001014682.1	COG1086 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]
YP_001014683.1	COG472 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]
YP_001014684.1	COG451 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]
YP_001014685.1	COG438 Glycosyltransferase [Cell envelope biogenesis, outer membrane]
YP_001014687.1	COG677 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]
YP_001014688.1	COG367 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]
YP_001014695.1	COG2089 Sialic acid synthase [Cell envelope biogenesis, outer membrane]
YP_001014696.1	COG381 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]
YP_001014697.1	COG1083 CMP-N-acetylneuraminic acid synthetase [Cell envelope biogenesis, outer membrane]
YP_001014698.1	COG107 Imidazole glycerol-phosphate synthase [Amino acid transport and metabolism]
YP_001014699.1	COG118 Glutamine amidotransferase [Amino acid transport and metabolism]
YP_001014700.1	COG3206 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]
YP_001014711.1	COG4448 L-asparaginase II [Amino acid transport and metabolism]
YP_001014713.1	COG799 Uncharacterized homolog of plant Iojap protein [Function unknown]
YP_001014716.1	four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity
YP_001014717.1	oxidative; catalyzes the formation of divinylprotochlorophyllide from magnesium-protoporphyrin IX 13-monomethyl ester in isocyclic ring formation in chlorophyll biosynthesis
YP_001014718.1	COG633 Ferredoxin [Energy production and conversion]
YP_001014721.1	COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]
YP_001014724.1	COG4586 ABC-type uncharacterized transport system, ATPase component [General function prediction only]
YP_001014725.1	COG4587 ABC-type uncharacterized transport system, permease component [General function prediction only]
YP_001014726.1	COG3694 ABC-type uncharacterized transport system, permease component [General function prediction only]
YP_001014727.1	COG1914 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]
YP_001014735.1	COG730 Predicted permeases [General function prediction only]
YP_001014737.1	COG366 Glycosidases [Carbohydrate transport and metabolism]
YP_001014738.1	catalyzes the hydrolysis of mannosyl-3-phosphoglycerate to form the osmolyte mannosylglycerate
YP_001014739.1	COG4240 Predicted kinase [General function prediction only]
YP_001014743.1	BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell
YP_001014746.1	COG225 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]
YP_001014748.1	COG1132 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]
YP_001014750.1	Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate
YP_001014751.1	catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers
YP_001014752.1	COG1366 Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) [Signal transduction mechanisms]
YP_001014753.1	COG1939 Uncharacterized protein conserved in bacteria [Function unknown]
YP_001014754.1	COG566 rRNA methylases [Translation, ribosomal structure and biogenesis]
YP_001014756.1	allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA
YP_001014757.1	catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase
YP_001014759.1	primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence
YP_001014760.1	plays an essential role in ATP-dependent branch migration of the Holliday junction
YP_001014762.1	COG697 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]
YP_001014763.1	synthesizes RNA primers at the replication forks
YP_001014766.1	COG389 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]
YP_001014767.1	COG1974 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]
YP_001014768.1	COG1576 Uncharacterized conserved protein [Function unknown]
YP_001014770.1	catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin
YP_001014771.1	catalyzes the phosphorylation of 4-diphosphocytidyl-2-C-methyl-D-erythritol in the nonmevalonate pathway of isoprenoid biosynthesis
YP_001014774.1	COG22 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]
YP_001014775.1	part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane
YP_001014776.1	forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF
YP_001014779.1	COG1807 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]
YP_001014785.1	subunit VIII; plays a crucial role in complex assembly and/or stability; with PetL, PetG and PetM makes up the small subunit of the cytochrome b6-f complex; cytochrome b6-f mediates electron transfer between photosystem II and photosystem I
YP_001014786.1	Psb29; involved in biogenesis of the photosystem II; in Arabidopsis it interacts with the heterotrimeric G-protein (GPA1) and seems to be involved in a D-glucose signaling mechanism between plastid and the plasma membranes
YP_001014787.1	hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; in Synechococcus this protein (ClpP1)is constitutive and levels increased with the increase of light.
YP_001014788.1	COG465 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]
YP_001014789.1	COG577 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]
YP_001014790.1	catalyzes the formation of phosphoenolpyruvate from pyruvate
YP_001014791.1	COG1694 Predicted pyrophosphatase [General function prediction only]
YP_001014792.1	COG762 Predicted integral membrane protein [Function unknown]
YP_001014793.1	COG1386 Predicted transcriptional regulator containing the HTH domain [Transcription]
YP_001014794.1	threonine deaminase; threonine dehydratase; in Escherichia coli, IlvA is part of the isoleucine biosynthetic pathway
YP_001014795.1	catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate
YP_001014799.1	COG1225 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]
YP_001014801.1	required for 70S ribosome assembly
YP_001014802.1	molecular chaperone
YP_001014803.1	May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
YP_001014804.1	COG483 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]
YP_001014805.1	ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation
YP_001014806.1	COG581 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]
YP_001014807.1	COG573 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]
YP_001014808.1	heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria
YP_001014809.1	COG484 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
YP_001014811.1	catalyzes the cleavage of the lactyl ether moiety of N-acetylmuramic acid-6-phosphate (MurNAc-6-P) to form N-acetylglucosamine-6-phosphate (GlcNAc-6-P) and lactate; involved in MurNAc dissimilation pathway
YP_001014812.1	COG652 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones]
YP_001014813.1	bifunctional enzyme DHBP synthase/GTP cyclohydrolase II; functions in riboflavin synthesis; converts GTP to 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine; converts ribulose 5-phopshate to 3,4-dihydroxy-2-butanone 4-phosphate; note this protein has an additional C-terminal tail of unknown function as compared to similar bifunctional enzymes
YP_001014814.1	catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate
YP_001014815.1	COG299 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]
YP_001014816.1	functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family
YP_001014817.1	leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase
YP_001014818.1	involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate
YP_001014819.1	COG1104 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]
YP_001014822.1	Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA
YP_001014823.1	COG1853 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]
YP_001014824.1	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
YP_001014825.1	COG1981 Predicted membrane protein [Function unknown]
YP_001014826.1	COG613 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]
YP_001014827.1	COG1429 Cobalamin biosynthesis protein CobN and related Mg-chelatases [Coenzyme metabolism]
YP_001014828.1	catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids
YP_001014829.1	COG1410 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]
YP_001014831.1	COG4360 ATP adenylyltransferase (5',5'''-P-1,P-4-tetraphosphate phosphorylase II) [Nucleotide transport and metabolism]
YP_001014834.1	catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily
YP_001014835.1	in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif
YP_001014836.1	binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit
YP_001014838.1	methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content
YP_001014841.1	COG2087 Adenosyl cobinamide kinase/adenosyl cobinamide phosphate guanylyltransferase [Coenzyme metabolism]
YP_001014842.1	COG219 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]
YP_001014853.1	COG5135 Uncharacterized conserved protein [Function unknown]
YP_001014856.1	COG450 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]
YP_001014857.1	COG465 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]
YP_001014858.1	some L32 proteins have zinc finger motifs consisting of CXXC while others do not
YP_001014860.1	COG637 Predicted phosphatase/phosphohexomutase [General function prediction only]
YP_001014861.1	COG608 Single-stranded DNA-specific exonuclease [DNA replication, recombination, and repair]
YP_001014865.1	COG557 Exoribonuclease R [Transcription]
YP_001014866.1	COG163 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]
YP_001014869.1	COG312 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]
YP_001014870.1	COG312 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]
YP_001014871.1	COG223 Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]
YP_001014872.1	COG861 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]
YP_001014874.1	COG1197 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]
YP_001014880.1	catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis
YP_001014882.1	COG654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]
YP_001014884.1	catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis
YP_001014885.1	catalyzes the formation of Mg-protoporphyrin IX from protoporphyrin IX and Mg(2+); first committed step of chlorophyll biosynthesis
YP_001014886.1	COG294 Dihydropteroate synthase and related enzymes [Coenzyme metabolism]
YP_001014887.1	Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate
YP_001014888.1	COG2501 Uncharacterized conserved protein [Function unknown]
YP_001014889.1	COG1132 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]
YP_001014891.1	COG5470 Uncharacterized conserved protein [Function unknown]
YP_001014893.1	COG572 Uridine kinase [Nucleotide transport and metabolism]
YP_001014898.1	COG702 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]
YP_001014905.1	COG3239 Fatty acid desaturase [Lipid metabolism]
YP_001014907.1	COG3340 Peptidase E [Amino acid transport and metabolism]
YP_001014908.1	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]
YP_001014909.1	COG2220 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]
YP_001014917.1	COG569 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]
YP_001014924.1	COG4487 Uncharacterized protein conserved in bacteria [Function unknown]
YP_001014949.1	COG11 Uncharacterized conserved protein [Function unknown]
YP_001014969.1	COG664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
YP_001014970.1	COG745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]
YP_001014971.1	COG642 Signal transduction histidine kinase [Signal transduction mechanisms]
YP_001014975.1	COG226 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]
YP_001014978.1	COG2059 Chromate transport protein ChrA [Inorganic ion transport and metabolism]
YP_001014980.1	COG57 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]
YP_001014981.1	COG640 Predicted transcriptional regulators [Transcription]
YP_001014982.1	COG798 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]
YP_001014999.1	COG5470 Uncharacterized conserved protein [Function unknown]
YP_001015000.1	COG1611 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]
YP_001015002.1	COG3686 Predicted membrane protein [Function unknown]
YP_001015015.1	COG2135 Uncharacterized conserved protein [Function unknown]
YP_001015021.1	COG679 Predicted permeases [General function prediction only]
YP_001015034.1	COG1233 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]
YP_001015047.1	COG4446 Uncharacterized protein conserved in bacteria [Function unknown]
YP_001015048.1	COG778 Nitroreductase [Energy production and conversion]
YP_001015053.1	non-folate utilizing enzyme, catalyzes the production of beta-formyl glycinamide ribonucleotide from formate, ATP, and beta-GAR and a side reaction producing acetyl phosphate and ADP from acetate and ATP; involved in de novo purine biosynthesis
YP_001015063.1	COG518 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]
YP_001015075.1	COG4446 Uncharacterized protein conserved in bacteria [Function unknown]
YP_001015086.1	COG596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]
YP_001015097.1	COG546 Predicted phosphatases [General function prediction only]
YP_001015107.1	COG397 Uncharacterized conserved protein [Function unknown]
YP_001015150.1	5-formyluracil/5-hydroxymethyluracil DNA glycosylase; involved in base excision repair of DNA damaged by oxidation or by mutagenic agents; acts as DNA glycosylase that recognizes and removes damaged bases with a preference for oxidized pyrimidines; has apurinic/apyrimidinic lyase activity
YP_001015196.1	COG695 Glutaredoxin and related proteins [Posttranslational modification, protein turnover, chaperones]
YP_001015218.2	involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation; binds to the N-terminal domain of the chaperone ClpA
YP_001015224.1	COG633 Ferredoxin [Energy production and conversion]
YP_001015231.1	COG1187 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]
YP_001015247.1	COG1126 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]
YP_001015248.1	COG765 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]
YP_001015249.1	COG765 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]
YP_001015250.1	COG834 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]
YP_001015252.1	COG1359 Uncharacterized conserved protein [Function unknown]
YP_001015284.1	COG659 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]
YP_001015289.1	TrmFO; Gid; glucose-inhibited division protein; similar to GidA; the gene from Bacillus subtilis encodes a tRNA-methyltransferase that utilizes folate as the carbon donor and bound flavin as reductant; modifies tRNA at position 54 (uridine) of the T-psi loop to form a C5-methyluridine
YP_001015290.1	COG1233 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]
YP_001015291.1	COG745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]
YP_001015293.1	COG278 Glutaredoxin-related protein [Posttranslational modification, protein turnover, chaperones]
YP_001015294.1	COG271 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]
YP_001015295.1	COG204 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]
YP_001015296.1	involved in the de novo synthesis of pyridoxine (Vitamin B6)
YP_001015297.1	COG1330 Exonuclease V gamma subunit [DNA replication, recombination, and repair]
YP_001015298.1	COG2020  protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]
YP_001015299.1	COG1074 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]
YP_001015301.1	COG513 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]
YP_001015303.1	COG1132 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]
YP_001015305.1	COG353 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]
YP_001015306.1	catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group
YP_001015308.1	COG1054 Predicted sulfurtransferase [General function prediction only]
YP_001015309.1	COG502 Biotin synthase and related enzymes [Coenzyme metabolism]
YP_001015310.1	catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate
YP_001015311.1	COG1624 Uncharacterized conserved protein [Function unknown]
YP_001015312.1	COG19 Diaminopimelate decarboxylase [Amino acid transport and metabolism]
YP_001015313.1	COG456 Acetyltransferases [General function prediction only]
YP_001015314.1	COG542 ATPases with chaperone activity, ATP-binding subunit [Posttranslational modification, protein turnover, chaperones]
YP_001015315.1	COG371 Glycerol dehydrogenase and related enzymes [Energy production and conversion]
YP_001015316.1	COG596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]
YP_001015318.1	COG575 CDP-diglyceride synthetase [Lipid metabolism]
YP_001015319.1	COG1982 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]
YP_001015320.1	COG661 Predicted unusual protein kinase [General function prediction only]
YP_001015323.1	amylomaltase; acts to release glucose from maltodextrins
YP_001015325.1	catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP
YP_001015326.1	COG308 Aminopeptidase N [Amino acid transport and metabolism]
YP_001015329.1	interacts with the circadian clock regulator KaiC to maintain circadian rhythms
YP_001015330.1	COG1018 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]
YP_001015331.1	catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate
YP_001015333.1	COG3429 Glucose-6-P dehydrogenase subunit [Carbohydrate transport and metabolism]
YP_001015334.1	COG1797 Cobyrinic acid a,c-diamide synthase [Coenzyme metabolism]
YP_001015336.1	COG1963 Uncharacterized protein conserved in bacteria [Function unknown]
YP_001015337.1	COG142 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]
YP_001015338.1	catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate
YP_001015339.1	COG1480 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]
YP_001015342.1	catalyzes the formation of 2-isopropylmalate from acetyl-CoA and 2-oxoisovalerate in leucine biosynthesis
YP_001015343.1	COG1543 Uncharacterized conserved protein [Function unknown]
YP_001015344.1	COG644 Dehydrogenases (flavoproteins) [Energy production and conversion]
YP_001015345.1	negatively supercoils closed circular double-stranded DNA
YP_001015346.1	catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate
YP_001015347.1	COG526 Thiol-disulfide isomerase and thioredoxins [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]
YP_001015348.1	with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide
YP_001015349.1	COG742 N6-adenine-specific methylase [DNA replication, recombination, and repair]
YP_001015350.1	cytochrome b6-f complex subunit 5; plastohydroquinone/plastocyanin oxidoreductase; with PetL, PetM and PetN makes up the small subunit of the cytochrome b6-f complex; cytochrome b6-f mediates electron transfer between photosystem II and photosystem I
YP_001015352.1	COG565 rRNA methylase [Translation, ribosomal structure and biogenesis]
YP_001015353.1	COG2367 Beta-lactamase class A [Defense mechanisms]
YP_001015354.1	COG1239 Mg-chelatase subunit ChlI [Coenzyme metabolism]
YP_001015355.1	endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity
YP_001015356.1	COG212 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]
YP_001015357.1	COG2166 SufE protein probably involved in Fe-S center assembly [General function prediction only]
YP_001015358.1	catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine
YP_001015360.1	COG747 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]
YP_001015361.1	COG601 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]
YP_001015362.1	COG4188 Predicted dienelactone hydrolase [General function prediction only]
YP_001015365.1	COG524 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]
YP_001015374.1	COG3011 Uncharacterized protein conserved in bacteria [Function unknown]
YP_001015385.1	COG4338 Uncharacterized protein conserved in bacteria [Function unknown]
YP_001015386.1	COG3046 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]
YP_001015387.1	COG1225 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]
YP_001015389.1	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]
YP_001015391.1	COG1305 Transglutaminase-like enzymes,  cysteine proteases [Amino acid transport and metabolism]
YP_001015392.1	COG2307 Uncharacterized protein conserved in bacteria [Function unknown]
YP_001015393.1	COG2308 Uncharacterized conserved protein [Function unknown]
YP_001015395.1	COG2930 Uncharacterized conserved protein [Function unknown]
YP_001015396.1	COG3063 Tfp pilus assembly protein PilF [Cell motility and secretion / Intracellular trafficking and secretion]
YP_001015406.1	COG639 Diadenosine tetraphosphatase and related serine/threonine protein phosphatases [Signal transduction mechanisms]
YP_001015408.1	translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1
YP_001015409.1	COG845 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]
YP_001015410.1	has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair
YP_001015411.1	catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA
YP_001015412.1	COG733 Na+-dependent transporters of the SNF family [General function prediction only]
YP_001015413.1	catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate
YP_001015414.1	COG429 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]
YP_001015415.1	COG1282 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]
YP_001015417.1	COG3288 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]
YP_001015420.1	COG492 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]
YP_001015421.1	COG361 Translation initiation factor 1 (IF-1) [Translation, ribosomal structure and biogenesis]
YP_001015423.1	COG702 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]
YP_001015424.1	Ycf31; cytochrome b6-f complex subunit 7; with PetL, PetG and PetN makes up the small subunit of the cytochrome b6-f complex; cytochrome b6-f mediates electron transfer between photosystem II and photosystem I
YP_001015425.1	COG596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]
YP_001015426.1	with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit
YP_001015427.1	COG652 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones]
YP_001015428.1	required for the assembly of photosystem I complex
YP_001015431.1	COG424 Nucleotide-binding protein implicated in inhibition of septum formation [Cell division and chromosome partitioning]
YP_001015434.1	catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation
YP_001015439.1	COG2226 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]
YP_001015440.1	COG1840 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]
YP_001015441.1	COG3128 Uncharacterized iron-regulated protein [Function unknown]
YP_001015444.1	glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA
YP_001015461.1	COG1225 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]
YP_001015462.1	COG2227 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme metabolism]
YP_001015465.1	COG4095 Uncharacterized conserved protein [Function unknown]
YP_001015468.1	photosystem II reaction center subunit VI; associated with the reaction center of photosystem II
YP_001015471.1	An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group
YP_001015473.1	COG1807 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]
YP_001015474.1	COG438 Glycosyltransferase [Cell envelope biogenesis, outer membrane]
YP_001015475.1	possible pecM homolog; COG2510 Predicted membrane protein [Function unknown]
YP_001015476.1	COG616 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]
YP_001015477.1	COG4401 Chorismate mutase [Amino acid transport and metabolism]
YP_001015479.1	in Escherichia coli transcription of this gene is enhanced by polyamines
YP_001015482.1	similar to 60 kDa inner membrane protein family; functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria
YP_001015483.1	COG464 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]
YP_001015484.1	catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
YP_001015485.1	COG750 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]
YP_001015486.1	located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif
YP_001015487.1	COG1185 Polyribonucleotide nucleotidyltransferase (polynucleotide phosphorylase) [Translation, ribosomal structure and biogenesis]
YP_001015488.1	COG1218 3'-Phosphoadenosine 5'-phosphosulfate (PAPS) 3'-phosphatase [Inorganic ion transport and metabolism]
YP_001015489.1	COG313 Predicted methyltransferases [General function prediction only]
YP_001015492.1	COG3556 Predicted membrane protein [Function unknown]
YP_001015495.1	COG3063 Tfp pilus assembly protein PilF [Cell motility and secretion / Intracellular trafficking and secretion]
YP_001015500.1	COG1974 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]
YP_001015501.1	catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation
YP_001015503.1	COG465 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]
YP_001015504.1	COG117 Pyrimidine deaminase [Coenzyme metabolism]
YP_001015507.1	COG2242 Precorrin-6B methylase 2 [Coenzyme metabolism]
YP_001015508.1	catalyzes the phosphorylation of NAD to NADP
YP_001015509.1	catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily
YP_001015510.1	catalyzes the conversion of a phosphate monoester to an alcohol and a phosphate
YP_001015512.1	COG196 FAD synthase [Coenzyme metabolism]
YP_001015514.1	catalyzes the formation of thiamine monophosphate from 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate
YP_001015515.1	COG2104 Sulfur transfer protein involved in thiamine biosynthesis [Coenzyme metabolism]
YP_001015516.1	COG4371 Predicted membrane protein [Function unknown]
YP_001015518.1	COG1691 NCAIR mutase (PurE)-related proteins [General function prediction only]
YP_001015520.1	COG336 tRNA-(guanine-N1)-methyltransferase [Translation, ribosomal structure and biogenesis]
YP_001015521.1	Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome
YP_001015523.1	COG670 Integral membrane protein, interacts with FtsH [General function prediction only]
YP_001015524.1	COG1702 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]
YP_001015525.1	binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity
YP_001015526.1	COG541 Signal recognition particle GTPase [Intracellular trafficking and secretion]
YP_001015528.1	COG1071 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]
YP_001015529.1	COG568 DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) [Transcription]
YP_001015530.1	COG63 Predicted sugar kinase [Carbohydrate transport and metabolism]
YP_001015531.1	catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs
YP_001015532.1	COG815 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]
YP_001015536.1	involved in tryptophan biosynthesis; amino acid biosynthesis; converts 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate to C(1)-(3-indolyl)-glycerol 3-phosphate and carbon dioxide and water
YP_001015537.1	E3 component of pyruvate complex; catalyzes the oxidation of dihydrolipoamide to lipoamide
YP_001015538.1	COG566 rRNA methylases [Translation, ribosomal structure and biogenesis]
YP_001015540.1	adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active
YP_001015541.1	catalyzes the formation of N-acetyl-l-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine
YP_001015542.1	COG285 Folylpolyglutamate synthase [Coenzyme metabolism]
YP_001015543.1	COG277 FAD/FMN-containing dehydrogenases [Energy production and conversion]
YP_001015544.1	COG402 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]
YP_001015545.1	catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A)
YP_001015546.1	D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli
YP_001015548.1	COG1589 Cell division septal protein [Cell envelope biogenesis, outer membrane]
YP_001015549.1	GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function
YP_001015550.1	catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate
YP_001015551.1	COG635 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]
YP_001015553.1	COG4956 Integral membrane protein (PIN domain superfamily) [General function prediction only]
YP_001015554.1	ClpR variant present in an operon with ClpP3 in Synechococcus PCC7942; ClpR is missing the catalytic triad Ser-His-Asp characteristic of serine-type proteases; the exact function of ClpR and ClpP3 is unknown however they appear to be necessary for cell viability; hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates
YP_001015555.1	hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates
YP_001015556.1	catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis
YP_001015557.1	COG1270 Cobalamin biosynthesis protein CobD/CbiB [Coenzyme metabolism]
YP_001015558.1	COG2148 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]
YP_001015559.1	COG438 Glycosyltransferase [Cell envelope biogenesis, outer membrane]
YP_001015567.1	COG776 Bacterial nucleoid DNA-binding protein [DNA replication, recombination, and repair]
YP_001015569.1	COG1523 Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]
YP_001015570.1	COG2211 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]
YP_001015571.1	COG767 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]
YP_001015574.1	COG344 Predicted membrane protein [Function unknown]
YP_001015575.1	COG284 Orotidine-5'-phosphate decarboxylase [Nucleotide transport and metabolism]
YP_001015576.1	catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr)
YP_001015579.1	catalyzes the removal of N-terminal amino acids preferably leucine from various peptides
YP_001015580.1	COG225 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]
YP_001015581.1	catalyzes the formation of lipid A disaccharide from UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate, lipid A disaccharide is a precursor of lipid A that anchors LPS to the OM
YP_001015582.1	catalyzes the addition of (R)-3-hydroxytetradecanoyl to the glucosamine disaccharide in lipid A biosynthesis
YP_001015583.1	in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP
YP_001015584.1	zinc-dependent; catalyzes the deacetylation of UDP-(3-O-acyl)-N-acetylglucosamine to UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine in the second step of lipid A biosynthesis
YP_001015585.1	chloroplast outer envelope membrane protein homolog; COG4775 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]
YP_001015586.1	catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase
YP_001015587.1	catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis
YP_001015588.1	COG5002 Signal transduction histidine kinase [Signal transduction mechanisms]
YP_001015589.1	acts as a promotor non-specific transcription repressor
YP_001015590.1	Decreases the phosphorylation of KaiC, a component of the main circadian regulator in cyanobacteria
YP_001015591.1	COG261 Ribosomal protein L21 [Translation, ribosomal structure and biogenesis]
YP_001015592.1	involved in the peptidyltransferase reaction during translation
YP_001015594.1	COG130 Pseudouridine synthase [Translation, ribosomal structure and biogenesis]
YP_001015595.1	COG2385 Sporulation protein and related proteins [Cell division and chromosome partitioning]
YP_001015596.1	COG1234 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]
YP_001015600.1	COG633 Ferredoxin [Energy production and conversion]
YP_001015601.1	methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype
YP_001015602.1	catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate
YP_001015604.1	COG2302 Uncharacterized conserved protein, contains S4-like domain [Function unknown]
YP_001015606.1	UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation
YP_001015611.1	COG2203 FOG: GAF domain [Signal transduction mechanisms]
YP_001015614.1	COG1765 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]
YP_001015634.1	COG488 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]
YP_001015639.1	COG3063 Tfp pilus assembly protein PilF [Cell motility and secretion / Intracellular trafficking and secretion]
YP_001015640.1	COG5010 Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]
YP_001015641.1	COG3063 Tfp pilus assembly protein PilF [Cell motility and secretion / Intracellular trafficking and secretion]
YP_001015648.1	COG2947 Uncharacterized conserved protein [Function unknown]
YP_001015651.1	Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits
YP_001015652.1	COG443 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]
YP_001015654.1	catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
YP_001015655.1	COG1314 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]
YP_001015656.1	60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth
YP_001015657.1	10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring
YP_001015658.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit
YP_001015659.1	part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane
YP_001015661.1	COG6 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]
YP_001015662.1	COG1253 Hemolysins and related proteins containing CBS domains [General function prediction only]
YP_001015663.1	COG218 Predicted GTPase [General function prediction only]
YP_001015664.1	transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria
YP_001015665.1	COG171 NAD synthase [Coenzyme metabolism]
YP_001015668.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit
YP_001015669.1	produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit
YP_001015670.1	produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex
YP_001015671.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B' is part of the membrane proton channel.
YP_001015672.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.
YP_001015673.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0
YP_001015674.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0
YP_001015677.1	COG772 Bacterial cell division membrane protein [Cell division and chromosome partitioning]
YP_001015678.1	COG785 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]
YP_001015679.1	COG1333 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]
YP_001015680.1	NADPH-dependent; catalyzes the reduction of 7-cyano-7-deazaguanine to 7-aminomethyl-7-deazaguanine in queuosine biosynthesis
YP_001015682.1	COG347 Nitrogen regulatory protein PII [Amino acid transport and metabolism]
YP_001015683.1	COG1189 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]
YP_001015685.1	Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide
YP_001015686.1	class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle
YP_001015687.1	COG4581 Superfamily II RNA helicase [DNA replication, recombination, and repair]
YP_001015688.1	COG156 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]
YP_001015690.1	COG2226 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]
YP_001015691.1	COG132 Dethiobiotin synthetase [Coenzyme metabolism]
YP_001015692.1	COG161 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]
YP_001015694.1	glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA
YP_001015695.1	COG1453 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]
YP_001015696.1	COG1141 Ferredoxin [Energy production and conversion]
YP_001015699.1	COG1413 FOG: HEAT repeat [Energy production and conversion]
YP_001015701.1	COG591 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]
YP_001015702.1	23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance
YP_001015704.1	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter
YP_001015705.1	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
YP_001015706.1	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme
YP_001015707.1	COG84 Mg-dependent DNase [DNA replication, recombination, and repair]
YP_001015708.1	binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase
YP_001015709.1	catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer
YP_001015710.1	Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway
YP_001015711.1	COG265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
YP_001015712.1	COG779 Uncharacterized protein conserved in bacteria [Function unknown]
YP_001015713.1	modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination
YP_001015714.1	COG2740 Predicted nucleic-acid-binding protein implicated in transcription termination [Transcription]
YP_001015715.1	Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
YP_001015717.1	COG302 GTP cyclohydrolase I [Coenzyme metabolism]
YP_001015722.1	COG1108 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]
YP_001015723.1	COG735 Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism]
YP_001015724.1	COG1121 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]
YP_001015725.1	COG803 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]
YP_001015727.1	COG523  GTPases (G3E family) [General function prediction only]
YP_001015728.1	COG2319 FOG: WD40 repeat [General function prediction only]
YP_001015735.1	COG410 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]
YP_001015736.1	COG4674 Uncharacterized ABC-type transport system, ATPase component [General function prediction only]
YP_001015737.1	COG4177 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]
YP_001015738.1	COG559 Branched-chain amino acid ABC-type transport system, permease components [Amino acid transport and metabolism]
YP_001015739.1	COG683 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]
YP_001015740.1	COG378 Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase [Posttranslational modification, protein turnover, chaperones / Transcription]
YP_001015741.1	COG830 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]
YP_001015742.1	COG2371 Urease accessory protein UreE [Posttranslational modification, protein turnover, chaperones]
YP_001015743.1	COG829 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]
YP_001015744.1	UreA, with UreB and UreC catalyzes the hydrolysis of urea into ammonia and carbon dioxide; nickel metalloenzyme; accessory proteins UreD, UreE, UreF, and UreG are necessary for assembly of the metallocenter
YP_001015745.1	ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori and Yersinia enterocolitica the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 UreC (alpha) and 3 UreAB (gamma/beta); in Brucella suis the urease encoded by this operon (one of two urease-encoding operons found in its genome) is involved with urease activity, optimum growth, resistance to low-pH killing in-vitro and persistence in-vivo, while the other operon does not seem to be active
YP_001015746.1	ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alpha) and 3 ureAB (gamma/beta) subunits
YP_001015755.1	a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA
YP_001015758.1	COG1032 Fe-S oxidoreductase [Energy production and conversion]
YP_001015760.1	involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation; binds to the N-terminal domain of the chaperone ClpA
YP_001015761.1	catalyzes the interconversion of tetrahydrodipicolinate and L,L-diaminopimelate in lysine biosynthesis
YP_001015762.1	COG1530 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]
YP_001015763.1	RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids
YP_001015765.1	COG77 Prephenate dehydratase [Amino acid transport and metabolism]
YP_001015766.1	COG500 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]
YP_001015767.1	COG2802 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]
YP_001015768.1	NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex
YP_001015769.1	EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu
YP_001015770.1	EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene
YP_001015771.1	binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit
YP_001015772.2	interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance
YP_001015773.1	COG69 Glutamate synthase domain 2 [Amino acid transport and metabolism]
YP_001015775.1	catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group
YP_001015776.1	COG1010 Precorrin-3B methylase [Coenzyme metabolism]
YP_001015777.1	with PsaB binds the primary electron donor of photosystem I, P700, and subsequent electron acceptors as part of photosystem I
YP_001015778.1	with PsaA binds the primary electron donor of photosystem I, P700, and subsequent electron acceptors as part of photosystem I
YP_001015782.1	COG463 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]
YP_001015791.1	COG5010 Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]
YP_001015793.2	converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer
YP_001015794.1	COG1403 Restriction endonuclease [Defense mechanisms]
YP_001015795.1	recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2
YP_001015796.1	RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome
YP_001015797.1	forms a direct contact with the tRNA during translation
YP_001015798.1	in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit
YP_001015799.1	mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability
YP_001015800.1	is a component of the macrolide binding site in the peptidyl transferase center
YP_001015801.1	catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme
YP_001015802.1	located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3
YP_001015803.1	located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA
YP_001015804.1	COG563 Adenylate kinase and related kinases [Nucleotide transport and metabolism]
YP_001015805.1	forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase
YP_001015806.1	late assembly protein
YP_001015807.1	located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance
YP_001015808.1	binds 5S rRNA along with protein L5 and L25
YP_001015809.1	ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance
YP_001015810.1	binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
YP_001015811.1	part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13
YP_001015812.1	assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel
YP_001015813.1	binds to the 23S rRNA between the centers for peptidyl transferase and GTPase
YP_001015814.1	primary binding protein; helps mediate assembly; involved in translation fidelity
YP_001015815.1	one of the stabilizing components for the large ribosomal subunit
YP_001015816.1	located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e
YP_001015817.1	forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation
YP_001015818.1	binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center
YP_001015819.1	protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
YP_001015820.1	one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation
YP_001015821.1	binds third domain of 23S rRNA and protein L29; part of exit tunnel
YP_001015822.1	L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA
YP_001015823.1	binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin
YP_001015825.1	COG1142 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]
YP_001015827.1	catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs
YP_001015829.1	COG1199 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]
YP_001015830.1	catalyzes the formation of tyrosine from arogenate
YP_001015831.1	COG1233 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]
YP_001015832.1	COG3001 Uncharacterized protein conserved in bacteria [Function unknown]
YP_001015835.1	COG476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]
YP_001015836.1	COG2109 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]
YP_001015837.1	COG1606 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]
YP_001015838.1	Decarboxylation of S-adenosylmethionine provides the aminopropyl moiety required for spermidine biosynthesis from putrescine
YP_001015839.1	Required for DNA replication; binds preferentially to single-stranded, linear DNA
YP_001015841.1	catalyzes the formation of oxaloacetate from phosphoenolpyruvate
YP_001015842.1	COG2170 Uncharacterized conserved protein [Function unknown]
YP_001015843.1	COG147 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]
YP_001015845.1	COG642 Signal transduction histidine kinase [Signal transduction mechanisms]
YP_001015846.1	COG772 Bacterial cell division membrane protein [Cell division and chromosome partitioning]
YP_001015847.1	COG489 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]
YP_001015848.1	catalyzes the conversion of the propionic acid groups of rings I and III to vinyl groups during heme synthesis
YP_001015854.1	COG4370 Uncharacterized protein conserved in bacteria [Function unknown]
YP_001015857.1	COG667 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]
YP_001015859.1	catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis
YP_001015860.1	catalyzes the formation of pantothenate from pantoate and beta-alanine and the formation of cytidine diphosphate from cytidine monophosphate
YP_001015861.1	COG394 Protein-tyrosine-phosphatase [Signal transduction mechanisms]
YP_001015862.1	catalyzes the reduction of 15,16-dihydrobiliverdin to (3Z)-phycoerythrobilin
YP_001015863.1	catalyzes the reduction of biliverdin IX-alpha to 15,16-dihydrobiliverdin
YP_001015864.1	COG5398 Heme oxygenase [Inorganic ion transport and metabolism]
YP_001015865.1	Converts isocitrate to alpha ketoglutarate
YP_001015866.1	COG3395 Uncharacterized protein conserved in bacteria [Function unknown]
YP_001015867.1	COG1304 L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases [Energy production and conversion]
YP_001015868.1	COG2017 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]
YP_001015869.1	COG596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]
YP_001015870.1	COG475 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]
YP_001015871.1	COG58 Glucan phosphorylase [Carbohydrate transport and metabolism]
YP_001015874.1	COG571 dsRNA-specific ribonuclease [Transcription]
YP_001015876.1	Essential for efficient processing of 16S rRNA
YP_001015877.1	COG836 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]
YP_001015878.1	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source
YP_001015879.1	part of the core of the reaction center of photosystem I
YP_001015880.1	carries the fatty acid chain in fatty acid biosynthesis
YP_001015881.1	COG304 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]
YP_001015882.1	catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase
YP_001015883.1	required for the synthesis of the hydromethylpyrimidine moiety of thiamine
YP_001015885.1	COG1473 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]
YP_001015887.1	promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration
YP_001015888.1	binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation
YP_001015890.1	class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1
YP_001015891.1	COG745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]
YP_001015893.1	in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall
YP_001015894.1	functions in MreBCD complex in some organisms
YP_001015895.1	binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA
YP_001015896.1	COG586 Uncharacterized membrane-associated protein [Function unknown]
YP_001015897.1	catalyzes the formation of L-homocysteine from S-adenosyl-L-homocysteine
YP_001015898.1	COG802 Predicted ATPase or kinase [General function prediction only]
YP_001015899.1	COG524 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]
YP_001015900.1	COG1194 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]
YP_001015901.1	COG596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]
YP_001015902.1	COG568 DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) [Transcription]
YP_001015903.1	COG2239 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]
YP_001015904.1	COG386 Glutathione peroxidase [Posttranslational modification, protein turnover, chaperones]
YP_001015905.1	possibly involved in chromosome condensation; COG239 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]
YP_001015906.1	COG239 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]
YP_001015908.1	negatively supercoils closed circular double-stranded DNA
YP_001015909.1	IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity
YP_001015910.1	IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits
YP_001015911.1	COG1725 Predicted transcriptional regulators [Transcription]
YP_001015912.1	COG1045 Serine acetyltransferase [Amino acid transport and metabolism]
YP_001015913.1	COG1682 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]
YP_001015914.1	COG1134 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]
YP_001015915.1	functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; in some organisms, there are paralogous proteins that have been found to be nonessential but do function in secretion of a subset of exported proteins
YP_001015916.1	COG1089 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]
YP_001015921.1	COG2274 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]
YP_001015922.1	COG845 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]
YP_001015923.1	COG438 Glycosyltransferase [Cell envelope biogenesis, outer membrane]
YP_001015926.1	COG1089 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]
YP_001015927.1	COG438 Glycosyltransferase [Cell envelope biogenesis, outer membrane]
YP_001015929.1	COG1209 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]
YP_001015931.1	RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not
YP_001015933.1	This protein performs the mismatch recognition step during the DNA repair process
YP_001015934.1	COG2082 Precorrin isomerase [Coenzyme metabolism]
YP_001015935.1	required for the assembly and function of the DNAX complex which are required for the assembly of the beta subunit onto primed DNA
YP_001015936.1	catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP
YP_001015937.1	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion
YP_001015939.1	COG37 Predicted ATPase of the PP-loop superfamily implicated in cell cycle control [Cell division and chromosome partitioning]
YP_001015940.1	COG595 Predicted hydrolase of the metallo-beta-lactamase superfamily [General function prediction only]
YP_001015941.1	catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis
YP_001015942.1	COG136 Aspartate-semialdehyde dehydrogenase [Amino acid transport and metabolism]
YP_001015944.1	Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer
YP_001015945.1	COG740 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]
YP_001015946.1	binds and unfolds substrates as part of the ClpXP protease
YP_001015947.1	COG2812 DNA polymerase III, gamma/tau subunits [DNA replication, recombination, and repair]
YP_001015948.1	COG1215 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]
YP_001015949.1	COG2385 Sporulation protein and related proteins [Cell division and chromosome partitioning]
YP_001015950.1	COG291 Ribosomal protein L35 [Translation, ribosomal structure and biogenesis]
YP_001015951.1	binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit
YP_001015953.1	functions in thiamine (vitamin B1) biosynthesis; in Bacillus subtilis this enzyme catalyzes the formation of thiazole from dehydroxyglycine and 1-deoxy-D-xylulose-5-phosphate and ThiS-thiocarboxylate
YP_001015955.1	COG451 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]
YP_001015956.1	COG438 Glycosyltransferase [Cell envelope biogenesis, outer membrane]
YP_001015958.1	acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine
YP_001015959.1	part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor
YP_001015960.1	COG4100 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]
YP_001015962.1	COG1398 Fatty-acid desaturase [Lipid metabolism]
YP_001015963.1	in Escherichia coli this protein is wrapped around the base of the L1 stalk
YP_001015964.1	COG305 Replicative DNA helicase [DNA replication, recombination, and repair]
YP_001015965.1	GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs
YP_001015970.1	COG272 NAD-dependent DNA ligase (contains BRCT domain type II) [DNA replication, recombination, and repair]
YP_001015972.1	COG398 Uncharacterized conserved protein [Function unknown]
YP_001015973.1	valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain
YP_001015977.1	COG1694 Predicted pyrophosphatase [General function prediction only]
YP_001015978.1	catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine
YP_001015979.1	COG10 Arginase/agmatinase/formimionoglutamate hydrolase, arginase family [Amino acid transport and metabolism]
YP_001015981.1	catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein
YP_001015982.1	catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes
YP_001015983.1	CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer
YP_001015984.1	COG602 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]
YP_001015985.1	COG603 Predicted PP-loop superfamily ATPase [General function prediction only]
YP_001015986.1	COG147 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]
YP_001015987.1	COG115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]
YP_001015988.1	COG7 Uroporphyrinogen-III methylase [Coenzyme metabolism]
YP_001015991.1	ferredoxin-dependent assimilatory nitrite reductase
YP_001015992.1	COG2116 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]
YP_001015994.1	COG547 Anthranilate phosphoribosyltransferase [Amino acid transport and metabolism]
YP_001015996.1	COG2814 Arabinose efflux permease [Carbohydrate transport and metabolism]
YP_001015997.1	catalyzes the reversible transfer of the terminal phosphate of ATP to form a long chain polyphosphate
YP_001015998.1	COG568 DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) [Transcription]
YP_001015999.1	COG170 Dolichol kinase [Lipid metabolism]
YP_001016000.1	catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive
YP_001016001.1	catalyzes the conversion of citrate to isocitrate and the conversion of 2-methylaconitate to 2-methylisocitrate
YP_001016002.1	COG38 Chloride channel protein EriC [Inorganic ion transport and metabolism]
YP_001016004.1	COG788 Formyltetrahydrofolate hydrolase [Nucleotide transport and metabolism]
YP_001016005.1	COG665 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]
YP_001016006.1	heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria
YP_001016007.1	AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate
YP_001016009.1	binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21
YP_001016010.1	catalyzes the formation of 2-N(omega)-(L-arginino)succinate from L-citrulline and L-aspartate in arginine biosynthesis, AMP-forming
YP_001016013.1	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
YP_001016015.1	COG438 Glycosyltransferase [Cell envelope biogenesis, outer membrane]
YP_001016016.1	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
YP_001016017.1	COG497 ATPase involved in DNA repair [DNA replication, recombination, and repair]
YP_001016018.1	COG661 Predicted unusual protein kinase [General function prediction only]
YP_001016020.1	catalyzes the formation of L-threonine from O-phospho-L-homoserine