-- dump date 20140620_000410 -- class Genbank::misc_feature -- table misc_feature_note -- id note 167555000001 DNA polymerase III subunit beta; Validated; Region: PRK05643 167555000002 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 167555000003 putative DNA binding surface [nucleotide binding]; other site 167555000004 dimer interface [polypeptide binding]; other site 167555000005 beta-clamp/clamp loader binding surface; other site 167555000006 beta-clamp/translesion DNA polymerase binding surface; other site 167555000007 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 167555000008 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 167555000009 dimerization interface [polypeptide binding]; other site 167555000010 ATP binding site [chemical binding]; other site 167555000011 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 167555000012 dimerization interface [polypeptide binding]; other site 167555000013 ATP binding site [chemical binding]; other site 167555000014 amidophosphoribosyltransferase; Provisional; Region: PRK09246 167555000015 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 167555000016 active site 167555000017 tetramer interface [polypeptide binding]; other site 167555000018 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 167555000019 active site 167555000020 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit [DNA replication, recombination, and repair]; Region: GyrA; COG0188 167555000021 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 167555000022 CAP-like domain; other site 167555000023 active site 167555000024 primary dimer interface [polypeptide binding]; other site 167555000025 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 167555000026 binding surface 167555000027 TPR motif; other site 167555000028 TPR repeat; Region: TPR_11; pfam13414 167555000029 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 167555000030 binding surface 167555000031 Tetratricopeptide repeat; Region: TPR_16; pfam13432 167555000032 TPR motif; other site 167555000033 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 167555000034 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 167555000035 Uncharacterized conserved protein [Function unknown]; Region: COG2928 167555000036 transcription antitermination protein NusB; Provisional; Region: nusB; PRK09634 167555000037 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 167555000038 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 167555000039 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 167555000040 P loop; other site 167555000041 GTP binding site [chemical binding]; other site 167555000042 GAF domain; Region: GAF; cl17456 167555000043 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 167555000044 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 167555000045 argininosuccinate lyase; Provisional; Region: PRK00855 167555000046 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 167555000047 active sites [active] 167555000048 tetramer interface [polypeptide binding]; other site 167555000049 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 167555000050 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 167555000051 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 167555000052 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 167555000053 FMN binding site [chemical binding]; other site 167555000054 active site 167555000055 catalytic residues [active] 167555000056 substrate binding site [chemical binding]; other site 167555000057 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 167555000058 SelR domain; Region: SelR; pfam01641 167555000059 GrpE; Region: GrpE; pfam01025 167555000060 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 167555000061 dimer interface [polypeptide binding]; other site 167555000062 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 167555000063 chaperone protein DnaJ; Provisional; Region: PRK14293 167555000064 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 167555000065 HSP70 interaction site [polypeptide binding]; other site 167555000066 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 167555000067 substrate binding site [polypeptide binding]; other site 167555000068 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 167555000069 Zn binding sites [ion binding]; other site 167555000070 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 167555000071 dimer interface [polypeptide binding]; other site 167555000072 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 167555000073 CPxP motif; other site 167555000074 Predicted GTPases [General function prediction only]; Region: COG1162 167555000075 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 167555000076 RNA binding site [nucleotide binding]; other site 167555000077 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 167555000078 GTPase/Zn-binding domain interface [polypeptide binding]; other site 167555000079 GTP/Mg2+ binding site [chemical binding]; other site 167555000080 G4 box; other site 167555000081 G5 box; other site 167555000082 G1 box; other site 167555000083 Switch I region; other site 167555000084 G2 box; other site 167555000085 G3 box; other site 167555000086 Switch II region; other site 167555000087 hypothetical protein; Validated; Region: PRK00153 167555000088 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 167555000089 FAD binding domain; Region: FAD_binding_4; pfam01565 167555000090 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 167555000091 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 167555000092 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 167555000093 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 167555000094 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 167555000095 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK07403 167555000096 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 167555000097 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 167555000098 thiamine monophosphate kinase; Provisional; Region: PRK05731 167555000099 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 167555000100 ATP binding site [chemical binding]; other site 167555000101 dimerization interface [polypeptide binding]; other site 167555000102 cyclophilin_TLP40_like: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) similar ot the Spinach thylakoid lumen protein TLP40. Compared to the archetypal cyclophilin Human cyclophilin A, these proteins have similar peptidylprolyl...; Region: cyclophilin_TLP40_like; cd01924 167555000103 active site 167555000104 elongation factor P; Validated; Region: PRK00529 167555000105 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 167555000106 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 167555000107 RNA binding site [nucleotide binding]; other site 167555000108 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 167555000109 RNA binding site [nucleotide binding]; other site 167555000110 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 167555000111 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 167555000112 carboxyltransferase (CT) interaction site; other site 167555000113 biotinylation site [posttranslational modification]; other site 167555000114 4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK02746 167555000115 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 167555000116 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 167555000117 NADH(P)-binding; Region: NAD_binding_10; pfam13460 167555000118 putative NAD(P) binding site [chemical binding]; other site 167555000119 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 167555000120 active site 167555000121 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 167555000122 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 167555000123 homodimer interface [polypeptide binding]; other site 167555000124 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167555000125 catalytic residue [active] 167555000126 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 167555000127 GMP synthase; Reviewed; Region: guaA; PRK00074 167555000128 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 167555000129 AMP/PPi binding site [chemical binding]; other site 167555000130 candidate oxyanion hole; other site 167555000131 catalytic triad [active] 167555000132 potential glutamine specificity residues [chemical binding]; other site 167555000133 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 167555000134 ATP Binding subdomain [chemical binding]; other site 167555000135 Ligand Binding sites [chemical binding]; other site 167555000136 Dimerization subdomain; other site 167555000137 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 167555000138 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 167555000139 cofactor binding site; other site 167555000140 DNA binding site [nucleotide binding] 167555000141 substrate interaction site [chemical binding]; other site 167555000142 LlaMI restriction endonuclease; Region: RE_LlaMI; pfam09562 167555000143 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 167555000144 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 167555000145 C-terminal domain interface [polypeptide binding]; other site 167555000146 GSH binding site (G-site) [chemical binding]; other site 167555000147 dimer interface [polypeptide binding]; other site 167555000148 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 167555000149 N-terminal domain interface [polypeptide binding]; other site 167555000150 dimer interface [polypeptide binding]; other site 167555000151 substrate binding pocket (H-site) [chemical binding]; other site 167555000152 Uncharacterized conserved protein [Function unknown]; Region: COG3586 167555000153 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 167555000154 binding surface 167555000155 TPR repeat; Region: TPR_11; pfam13414 167555000156 TPR motif; other site 167555000157 TPR repeat; Region: TPR_11; pfam13414 167555000158 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 167555000159 binding surface 167555000160 TPR motif; other site 167555000161 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 167555000162 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 167555000163 TPR repeat; Region: TPR_11; pfam13414 167555000164 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 167555000165 binding surface 167555000166 TPR motif; other site 167555000167 Tetratricopeptide repeat; Region: TPR_12; pfam13424 167555000168 TPR repeat; Region: TPR_11; pfam13414 167555000169 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 167555000170 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 167555000171 TPR motif; other site 167555000172 TPR repeat; Region: TPR_11; pfam13414 167555000173 binding surface 167555000174 Methyltransferase domain; Region: Methyltransf_31; pfam13847 167555000175 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 167555000176 S-adenosylmethionine binding site [chemical binding]; other site 167555000177 Ion channel; Region: Ion_trans_2; pfam07885 167555000178 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 167555000179 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 167555000180 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 167555000181 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 167555000182 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 167555000183 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 167555000184 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 167555000185 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 167555000186 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 167555000187 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 167555000188 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 167555000189 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 167555000190 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 167555000191 motif 1; other site 167555000192 active site 167555000193 motif 2; other site 167555000194 motif 3; other site 167555000195 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 167555000196 arginine decarboxylase; Provisional; Region: PRK05354 167555000197 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 167555000198 dimer interface [polypeptide binding]; other site 167555000199 active site 167555000200 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 167555000201 catalytic residues [active] 167555000202 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 167555000203 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 167555000204 active site 167555000205 multimer interface [polypeptide binding]; other site 167555000206 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 167555000207 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 167555000208 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 167555000209 GatB domain; Region: GatB_Yqey; smart00845 167555000210 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 167555000211 dephospho-CoA kinase; Region: TIGR00152 167555000212 CoA-binding site [chemical binding]; other site 167555000213 ATP-binding [chemical binding]; other site 167555000214 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 167555000215 heterotetramer interface [polypeptide binding]; other site 167555000216 active site pocket [active] 167555000217 cleavage site 167555000218 Domain of unknown function (DUF4214); Region: DUF4214; pfam13946 167555000219 Domain of unknown function (DUF4214); Region: DUF4214; pfam13946 167555000220 Cation transport protein; Region: TrkH; cl17365 167555000221 cyanate hydratase; Validated; Region: PRK02866 167555000222 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 167555000223 non-specific DNA binding site [nucleotide binding]; other site 167555000224 salt bridge; other site 167555000225 sequence-specific DNA binding site [nucleotide binding]; other site 167555000226 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 167555000227 oligomer interface [polypeptide binding]; other site 167555000228 active site 167555000229 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 167555000230 binding surface 167555000231 TPR motif; other site 167555000232 TPR repeat; Region: TPR_11; pfam13414 167555000233 TPR repeat; Region: TPR_11; pfam13414 167555000234 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 167555000235 binding surface 167555000236 TPR motif; other site 167555000237 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 167555000238 binding surface 167555000239 TPR motif; other site 167555000240 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 167555000241 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 167555000242 binding surface 167555000243 TPR motif; other site 167555000244 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 167555000245 TPR repeat; Region: TPR_11; pfam13414 167555000246 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 167555000247 binding surface 167555000248 TPR motif; other site 167555000249 TPR repeat; Region: TPR_11; pfam13414 167555000250 TPR repeat; Region: TPR_11; pfam13414 167555000251 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 167555000252 binding surface 167555000253 TPR motif; other site 167555000254 Staphylococcal nuclease homologue; Region: SNase; pfam00565 167555000255 Catalytic site; other site 167555000256 Domain of unknown function (DUF4214); Region: DUF4214; pfam13946 167555000257 Domain of unknown function (DUF4214); Region: DUF4214; pfam13946 167555000258 Herpesvirus latent membrane protein 1 (LMP1); Region: Herpes_LMP1; pfam05297 167555000259 Domain of unknown function (DUF4214); Region: DUF4214; pfam13946 167555000260 Domain of unknown function (DUF4214); Region: DUF4214; pfam13946 167555000261 Domain of unknown function (DUF4214); Region: DUF4214; pfam13946 167555000262 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 167555000263 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996 167555000264 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 167555000265 active site 167555000266 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 167555000267 Domain of unknown function (DUF4214); Region: DUF4214; pfam13946 167555000268 Domain of unknown function (DUF4214); Region: DUF4214; pfam13946 167555000269 putative high light inducible protein; Region: PHA02337 167555000270 C factor cell-cell signaling protein; Provisional; Region: PRK09009 167555000271 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 167555000272 NADP binding site [chemical binding]; other site 167555000273 homodimer interface [polypeptide binding]; other site 167555000274 active site 167555000275 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 167555000276 ParA-like protein; Provisional; Region: PHA02518 167555000277 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 167555000278 P-loop; other site 167555000279 Magnesium ion binding site [ion binding]; other site 167555000280 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 167555000281 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 167555000282 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 167555000283 Walker A/P-loop; other site 167555000284 ATP binding site [chemical binding]; other site 167555000285 Q-loop/lid; other site 167555000286 ABC transporter signature motif; other site 167555000287 Walker B; other site 167555000288 D-loop; other site 167555000289 H-loop/switch region; other site 167555000290 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 167555000291 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 167555000292 Protein of unknown function (DUF3303); Region: DUF3303; pfam11746 167555000293 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 167555000294 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 167555000295 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 167555000296 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 167555000297 DNA polymerase Ligase (LigD); Region: LigD_N; pfam13298 167555000298 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 167555000299 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 167555000300 Walker A/P-loop; other site 167555000301 ATP binding site [chemical binding]; other site 167555000302 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 167555000303 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 167555000304 ABC transporter signature motif; other site 167555000305 Walker B; other site 167555000306 D-loop; other site 167555000307 H-loop/switch region; other site 167555000308 PRC-barrel domain; Region: PRC; pfam05239 167555000309 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 167555000310 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 167555000311 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 167555000312 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 167555000313 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 167555000314 YGGT family; Region: YGGT; pfam02325 167555000315 Ycf66 protein N-terminus; Region: Ycf66_N; pfam07444 167555000316 Protein of unknown function (DUF1509); Region: DUF1509; pfam07420 167555000317 Chlorophyll A-B binding protein; Region: Chloroa_b-bind; pfam00504 167555000318 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 167555000319 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 167555000320 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 167555000321 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 167555000322 nucleotide binding site/active site [active] 167555000323 HIT family signature motif; other site 167555000324 catalytic residue [active] 167555000325 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 167555000326 active site 167555000327 catalytic residues [active] 167555000328 metal binding site [ion binding]; metal-binding site 167555000329 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 167555000330 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 167555000331 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 167555000332 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 167555000333 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 167555000334 catalytic residue [active] 167555000335 FeS assembly protein SufD; Region: sufD; TIGR01981 167555000336 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 167555000337 sulfate ABC transporter protein; Validated; Region: ycf16; CHL00131 167555000338 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 167555000339 Walker A/P-loop; other site 167555000340 ATP binding site [chemical binding]; other site 167555000341 Q-loop/lid; other site 167555000342 ABC transporter signature motif; other site 167555000343 Walker B; other site 167555000344 D-loop; other site 167555000345 H-loop/switch region; other site 167555000346 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 167555000347 putative ABC transporter; Region: ycf24; CHL00085 167555000348 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 167555000349 phosphoglucomutase; Region: PLN02307 167555000350 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 167555000351 active site 167555000352 substrate binding site [chemical binding]; other site 167555000353 metal binding site [ion binding]; metal-binding site 167555000354 recombination factor protein RarA/unknown domain fusion protein; Reviewed; Region: PRK13341 167555000355 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167555000356 Walker A motif; other site 167555000357 ATP binding site [chemical binding]; other site 167555000358 Walker B motif; other site 167555000359 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 167555000360 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 167555000361 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 167555000362 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 167555000363 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 167555000364 catalytic triad [active] 167555000365 Type III pantothenate kinase; Region: Pan_kinase; cl17198 167555000366 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 167555000367 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 167555000368 Active Sites [active] 167555000369 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 167555000370 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 167555000371 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 167555000372 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 167555000373 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 167555000374 transmembrane helices; other site 167555000375 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 167555000376 TrkA-C domain; Region: TrkA_C; pfam02080 167555000377 TrkA-C domain; Region: TrkA_C; pfam02080 167555000378 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 167555000379 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 167555000380 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 167555000381 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 167555000382 TrkA-N domain; Region: TrkA_N; pfam02254 167555000383 TrkA-C domain; Region: TrkA_C; pfam02080 167555000384 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 167555000385 Protein of unknown function (DUF1662); Region: DUF1662; pfam07878 167555000386 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 167555000387 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 167555000388 Walker A/P-loop; other site 167555000389 ATP binding site [chemical binding]; other site 167555000390 Q-loop/lid; other site 167555000391 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 167555000392 ABC transporter; Region: ABC_tran_2; pfam12848 167555000393 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 167555000394 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 167555000395 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 167555000396 protein binding site [polypeptide binding]; other site 167555000397 Protein of unknown function (DUF2973); Region: DUF2973; pfam11189 167555000398 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 167555000399 generic binding surface II; other site 167555000400 generic binding surface I; other site 167555000401 Exonuclease VII, large subunit; Region: Exonuc_VII_L; pfam02601 167555000402 Exonuclease VII small subunit; Region: Exonuc_VII_S; pfam02609 167555000403 Reverse gyrase [DNA replication, recombination, and repair]; Region: COG1110 167555000404 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 167555000405 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 167555000406 Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643 167555000407 active site 167555000408 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 167555000409 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 167555000410 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 167555000411 Protein of unknown function (DUF512); Region: DUF512; pfam04459 167555000412 Protein of unknown function (DUF3120); Region: DUF3120; pfam11318 167555000413 L-aspartate oxidase; Provisional; Region: PRK07395 167555000414 L-aspartate oxidase; Provisional; Region: PRK06175 167555000415 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 167555000416 Vitamin K epoxide reductase (VKOR) family; Region: VKOR; cl01729 167555000417 putative active site [active] 167555000418 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 167555000419 Domain of unknown function (DUF4346); Region: DUF4346; pfam14251 167555000420 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 167555000421 Protein of unknown function, DUF482; Region: DUF482; pfam04339 167555000422 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 167555000423 RibD C-terminal domain; Region: RibD_C; cl17279 167555000424 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 167555000425 active site 167555000426 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 167555000427 active site 167555000428 shikimate kinase; Reviewed; Region: aroK; PRK00131 167555000429 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 167555000430 ADP binding site [chemical binding]; other site 167555000431 magnesium binding site [ion binding]; other site 167555000432 putative shikimate binding site; other site 167555000433 Protein of unknown function (DUF3571); Region: DUF3571; pfam12095 167555000434 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 167555000435 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 167555000436 C-terminal domain interface [polypeptide binding]; other site 167555000437 GSH binding site (G-site) [chemical binding]; other site 167555000438 dimer interface [polypeptide binding]; other site 167555000439 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 167555000440 N-terminal domain interface [polypeptide binding]; other site 167555000441 Protein of unknown function (DUF751); Region: DUF751; pfam05421 167555000442 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 167555000443 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 167555000444 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 167555000445 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 167555000446 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 167555000447 active site 167555000448 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 167555000449 putative hydrophobic ligand binding site [chemical binding]; other site 167555000450 9,9'-di-cis-zeta-carotene desaturase; Region: zeta_caro_desat; TIGR02732 167555000451 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 167555000452 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 167555000453 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 167555000454 binding surface 167555000455 TPR motif; other site 167555000456 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 167555000457 TIGR01777 family protein; Region: yfcH 167555000458 putative NAD(P) binding site [chemical binding]; other site 167555000459 putative active site [active] 167555000460 Cyanobacterial and plant NDH-1 subunit O; Region: NdhO; pfam11910 167555000461 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 167555000462 HSP70 interaction site [polypeptide binding]; other site 167555000463 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 167555000464 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 167555000465 dimer interface [polypeptide binding]; other site 167555000466 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167555000467 catalytic residue [active] 167555000468 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 167555000469 hypothetical protein; Provisional; Region: PRK13683 167555000470 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 167555000471 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 167555000472 Walker A/P-loop; other site 167555000473 ATP binding site [chemical binding]; other site 167555000474 Q-loop/lid; other site 167555000475 ABC transporter signature motif; other site 167555000476 Walker B; other site 167555000477 D-loop; other site 167555000478 H-loop/switch region; other site 167555000479 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 167555000480 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 167555000481 active site 167555000482 phosphorylation site [posttranslational modification] 167555000483 intermolecular recognition site; other site 167555000484 dimerization interface [polypeptide binding]; other site 167555000485 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 167555000486 DNA binding site [nucleotide binding] 167555000487 DNA polymerase III subunit delta'; Validated; Region: PRK07399 167555000488 DNA polymerase III subunit delta'; Validated; Region: PRK08485 167555000489 thymidylate kinase; Validated; Region: tmk; PRK00698 167555000490 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 167555000491 TMP-binding site; other site 167555000492 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 167555000493 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 167555000494 metal-binding site [ion binding] 167555000495 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 167555000496 photosystem I assembly protein Ycf3; Provisional; Region: PRK02603 167555000497 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 167555000498 binding surface 167555000499 TPR motif; other site 167555000500 DNA repair protein RadA; Provisional; Region: PRK11823 167555000501 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 167555000502 Walker A motif; other site 167555000503 ATP binding site [chemical binding]; other site 167555000504 Walker B motif; other site 167555000505 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 167555000506 Ycf27; Reviewed; Region: orf27; CHL00148 167555000507 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 167555000508 active site 167555000509 phosphorylation site [posttranslational modification] 167555000510 intermolecular recognition site; other site 167555000511 dimerization interface [polypeptide binding]; other site 167555000512 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 167555000513 DNA binding site [nucleotide binding] 167555000514 putative glycerol-3-phosphate acyltransferase PlsX; Provisional; Region: PRK13845 167555000515 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 167555000516 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 167555000517 dimer interface [polypeptide binding]; other site 167555000518 active site 167555000519 CoA binding pocket [chemical binding]; other site 167555000520 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 167555000521 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 167555000522 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 167555000523 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 167555000524 putative acyl-acceptor binding pocket; other site 167555000525 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 167555000526 Hypothetical chloroplast protein Ycf34; Region: Ycf34; pfam10718 167555000527 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 167555000528 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 167555000529 active site 167555000530 NTP binding site [chemical binding]; other site 167555000531 metal binding triad [ion binding]; metal-binding site 167555000532 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 167555000533 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 167555000534 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 167555000535 active site lid residues [active] 167555000536 substrate binding pocket [chemical binding]; other site 167555000537 catalytic residues [active] 167555000538 substrate-Mg2+ binding site; other site 167555000539 aspartate-rich region 1; other site 167555000540 aspartate-rich region 2; other site 167555000541 phytoene desaturase; Region: phytoene_desat; TIGR02731 167555000542 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 167555000543 Cyanobacterial and plastid NDH-1 subunit M; Region: NdhM; pfam10664 167555000544 Protein of unknown function (DUF3172); Region: DUF3172; pfam11371 167555000545 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 167555000546 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 167555000547 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 167555000548 putative dimerization interface [polypeptide binding]; other site 167555000549 Predicted membrane protein [Function unknown]; Region: COG4094 167555000550 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07376 167555000551 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 167555000552 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 167555000553 NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010 167555000554 NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK02546 167555000555 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 167555000556 ScpA/B protein; Region: ScpA_ScpB; cl00598 167555000557 glucose-1-phosphate adenylyltransferase; Region: glgC; TIGR02091 167555000558 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 167555000559 active site 167555000560 Substrate binding site; other site 167555000561 Mg++ binding site; other site 167555000562 Left-handed parallel beta-Helix (LbH) domain of a group of proteins with similarity to glucose-1-phosphate adenylyltransferase: Included in this family are glucose-1-phosphate adenylyltransferase, mannose-1-phosphate guanylyltransferase, and the...; Region: LbH_G1P_AT_C_like; cd03356 167555000563 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 167555000564 FAD binding site [chemical binding]; other site 167555000565 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 167555000566 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 167555000567 DNA binding residues [nucleotide binding] 167555000568 dimerization interface [polypeptide binding]; other site 167555000569 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 167555000570 putative active site [active] 167555000571 putative metal binding residues [ion binding]; other site 167555000572 signature motif; other site 167555000573 putative dimer interface [polypeptide binding]; other site 167555000574 putative phosphate binding site [ion binding]; other site 167555000575 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02645 167555000576 ATP-NAD kinase; Region: NAD_kinase; pfam01513 167555000577 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 167555000578 NADH dehydrogenase subunit 6; Region: ndhG; CHL00016 167555000579 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 167555000580 NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213 167555000581 NADH-plastoquinone oxidoreductase subunit I protein; Region: ndhI; TIGR00403 167555000582 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 167555000583 NADH dehydrogenase; Region: NADHdh; cl00469 167555000584 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 167555000585 citrate synthase; Provisional; Region: PRK14036 167555000586 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 167555000587 oxalacetate binding site [chemical binding]; other site 167555000588 citrylCoA binding site [chemical binding]; other site 167555000589 coenzyme A binding site [chemical binding]; other site 167555000590 catalytic triad [active] 167555000591 Protein of unknown function (DUF3352); Region: DUF3352; pfam11832 167555000592 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 167555000593 active site residue [active] 167555000594 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 167555000595 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 167555000596 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167555000597 catalytic residue [active] 167555000598 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 167555000599 putative rRNA binding site [nucleotide binding]; other site 167555000600 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 167555000601 ligand-binding site [chemical binding]; other site 167555000602 AIR carboxylase; Region: AIRC; pfam00731 167555000603 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 167555000604 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 167555000605 active site 167555000606 Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580 167555000607 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 167555000608 S-adenosylmethionine binding site [chemical binding]; other site 167555000609 Magnesium-protoporphyrin IX methyltransferase C-terminus; Region: Mg-por_mtran_C; pfam07109 167555000610 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 167555000611 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 167555000612 active site 167555000613 phosphorylation site [posttranslational modification] 167555000614 intermolecular recognition site; other site 167555000615 dimerization interface [polypeptide binding]; other site 167555000616 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 167555000617 DNA binding residues [nucleotide binding] 167555000618 dimerization interface [polypeptide binding]; other site 167555000619 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 167555000620 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 167555000621 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 167555000622 catalytic residue [active] 167555000623 MraW methylase family; Region: Methyltransf_5; cl17771 167555000624 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 167555000625 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 167555000626 NAD(P)H-quinone oxidoreductase subunit H; Validated; Region: PRK07415 167555000627 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 167555000628 active site 167555000629 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 167555000630 CoA binding site [chemical binding]; other site 167555000631 active site 167555000632 AMP binding site [chemical binding]; other site 167555000633 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 167555000634 o-succinylbenzoate synthase; Region: menC_gamma/gm+; TIGR01927 167555000635 active site 167555000636 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK07419 167555000637 UbiA prenyltransferase family; Region: UbiA; pfam01040 167555000638 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 167555000639 chorismate binding enzyme; Region: Chorismate_bind; cl10555 167555000640 glutathione synthetase; Provisional; Region: PRK05246 167555000641 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 167555000642 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 167555000643 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 167555000644 GSH binding site [chemical binding]; other site 167555000645 catalytic residues [active] 167555000646 This domain is found in peptide chain release factors; Region: PCRF; smart00937 167555000647 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 167555000648 RF-1 domain; Region: RF-1; pfam00472 167555000649 Protein of unknown function (DUF3285); Region: DUF3285; pfam11688 167555000650 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 167555000651 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 167555000652 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 167555000653 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 167555000654 glutamine binding [chemical binding]; other site 167555000655 catalytic triad [active] 167555000656 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 167555000657 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 167555000658 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167555000659 homodimer interface [polypeptide binding]; other site 167555000660 catalytic residue [active] 167555000661 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 167555000662 arginine-tRNA ligase; Region: PLN02286 167555000663 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 167555000664 active site 167555000665 HIGH motif; other site 167555000666 KMSK motif region; other site 167555000667 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 167555000668 tRNA binding surface [nucleotide binding]; other site 167555000669 anticodon binding site; other site 167555000670 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 167555000671 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 167555000672 dimerization interface [polypeptide binding]; other site 167555000673 active site 167555000674 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 167555000675 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 167555000676 trmE is a tRNA modification GTPase; Region: trmE; cd04164 167555000677 G1 box; other site 167555000678 GTP/Mg2+ binding site [chemical binding]; other site 167555000679 Switch I region; other site 167555000680 G2 box; other site 167555000681 Switch II region; other site 167555000682 G3 box; other site 167555000683 G4 box; other site 167555000684 G5 box; other site 167555000685 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 167555000686 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 167555000687 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 167555000688 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 167555000689 Zn2+ binding site [ion binding]; other site 167555000690 Mg2+ binding site [ion binding]; other site 167555000691 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 167555000692 synthetase active site [active] 167555000693 NTP binding site [chemical binding]; other site 167555000694 metal binding site [ion binding]; metal-binding site 167555000695 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 167555000696 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 167555000697 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 167555000698 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 167555000699 Walker A/P-loop; other site 167555000700 ATP binding site [chemical binding]; other site 167555000701 Q-loop/lid; other site 167555000702 ABC transporter signature motif; other site 167555000703 Walker B; other site 167555000704 D-loop; other site 167555000705 H-loop/switch region; other site 167555000706 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 167555000707 Walker A/P-loop; other site 167555000708 ATP binding site [chemical binding]; other site 167555000709 Q-loop/lid; other site 167555000710 ABC transporter signature motif; other site 167555000711 Walker B; other site 167555000712 D-loop; other site 167555000713 H-loop/switch region; other site 167555000714 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 167555000715 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 167555000716 RNA binding surface [nucleotide binding]; other site 167555000717 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 167555000718 active site 167555000719 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 167555000720 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 167555000721 GTP/Mg2+ binding site [chemical binding]; other site 167555000722 G4 box; other site 167555000723 G5 box; other site 167555000724 G1 box; other site 167555000725 Switch I region; other site 167555000726 G2 box; other site 167555000727 G3 box; other site 167555000728 Switch II region; other site 167555000729 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 167555000730 Phosphoglycerate kinase; Region: PGK; pfam00162 167555000731 substrate binding site [chemical binding]; other site 167555000732 hinge regions; other site 167555000733 ADP binding site [chemical binding]; other site 167555000734 catalytic site [active] 167555000735 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 167555000736 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 167555000737 active site 167555000738 homodimer interface [polypeptide binding]; other site 167555000739 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 167555000740 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 167555000741 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167555000742 homodimer interface [polypeptide binding]; other site 167555000743 catalytic residue [active] 167555000744 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 167555000745 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 167555000746 quinone interaction residues [chemical binding]; other site 167555000747 active site 167555000748 catalytic residues [active] 167555000749 FMN binding site [chemical binding]; other site 167555000750 substrate binding site [chemical binding]; other site 167555000751 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 167555000752 RNA/DNA hybrid binding site [nucleotide binding]; other site 167555000753 active site 167555000754 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 167555000755 L11 interface [polypeptide binding]; other site 167555000756 putative EF-Tu interaction site [polypeptide binding]; other site 167555000757 putative EF-G interaction site [polypeptide binding]; other site 167555000758 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 167555000759 23S rRNA interface [nucleotide binding]; other site 167555000760 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 167555000761 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 167555000762 mRNA/rRNA interface [nucleotide binding]; other site 167555000763 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 167555000764 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 167555000765 23S rRNA interface [nucleotide binding]; other site 167555000766 L7/L12 interface [polypeptide binding]; other site 167555000767 putative thiostrepton binding site; other site 167555000768 L25 interface [polypeptide binding]; other site 167555000769 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 167555000770 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 167555000771 putative homodimer interface [polypeptide binding]; other site 167555000772 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 167555000773 heterodimer interface [polypeptide binding]; other site 167555000774 homodimer interface [polypeptide binding]; other site 167555000775 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 167555000776 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 167555000777 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167555000778 Walker A motif; other site 167555000779 ATP binding site [chemical binding]; other site 167555000780 Walker B motif; other site 167555000781 arginine finger; other site 167555000782 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167555000783 Walker A motif; other site 167555000784 ATP binding site [chemical binding]; other site 167555000785 Walker B motif; other site 167555000786 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 167555000787 enolase; Provisional; Region: eno; PRK00077 167555000788 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 167555000789 dimer interface [polypeptide binding]; other site 167555000790 metal binding site [ion binding]; metal-binding site 167555000791 substrate binding pocket [chemical binding]; other site 167555000792 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 167555000793 ABC1 family; Region: ABC1; cl17513 167555000794 ABC1 family; Region: ABC1; cl17513 167555000795 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 167555000796 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 167555000797 Nitrogen regulatory protein P-II; Region: P-II; cl00412 167555000798 Domain of unknown function (DUF897); Region: DUF897; pfam05982 167555000799 high affinity sulphate transporter 1; Region: sulP; TIGR00815 167555000800 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 167555000801 Sulfate transporter family; Region: Sulfate_transp; pfam00916 167555000802 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 167555000803 chaperone protein DnaJ; Provisional; Region: PRK14299 167555000804 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 167555000805 HSP70 interaction site [polypeptide binding]; other site 167555000806 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 167555000807 substrate binding site [polypeptide binding]; other site 167555000808 dimer interface [polypeptide binding]; other site 167555000809 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 167555000810 dimer interface [polypeptide binding]; other site 167555000811 active site 167555000812 aspartate-rich active site metal binding site; other site 167555000813 allosteric magnesium binding site [ion binding]; other site 167555000814 Schiff base residues; other site 167555000815 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 167555000816 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 167555000817 active site 167555000818 metal binding site [ion binding]; metal-binding site 167555000819 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 167555000820 MutS domain III; Region: MutS_III; pfam05192 167555000821 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 167555000822 Walker A/P-loop; other site 167555000823 ATP binding site [chemical binding]; other site 167555000824 Q-loop/lid; other site 167555000825 ABC transporter signature motif; other site 167555000826 Walker B; other site 167555000827 D-loop; other site 167555000828 H-loop/switch region; other site 167555000829 Smr domain; Region: Smr; pfam01713 167555000830 GTPase CgtA; Reviewed; Region: obgE; PRK12299 167555000831 GTP1/OBG; Region: GTP1_OBG; pfam01018 167555000832 Obg GTPase; Region: Obg; cd01898 167555000833 G1 box; other site 167555000834 GTP/Mg2+ binding site [chemical binding]; other site 167555000835 Switch I region; other site 167555000836 G2 box; other site 167555000837 G3 box; other site 167555000838 Switch II region; other site 167555000839 G4 box; other site 167555000840 G5 box; other site 167555000841 CP12 domain; Region: CP12; pfam02672 167555000842 Uncharacterized integral membrane protein (DUF2301); Region: DUF2301; pfam10063 167555000843 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 167555000844 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 167555000845 putative dimer interface [polypeptide binding]; other site 167555000846 N-terminal domain interface [polypeptide binding]; other site 167555000847 putative substrate binding pocket (H-site) [chemical binding]; other site 167555000848 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 167555000849 Peptidase M14 Aspartoacylase (ASPA) subfamily; Region: M14_ASPA; cd06909 167555000850 active site 167555000851 Zn binding site [ion binding]; other site 167555000852 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 167555000853 protein I interface; other site 167555000854 D2 interface; other site 167555000855 protein T interface; other site 167555000856 chlorophyll binding site; other site 167555000857 beta carotene binding site; other site 167555000858 pheophytin binding site; other site 167555000859 manganese-stabilizing polypeptide interface; other site 167555000860 CP43 interface; other site 167555000861 protein L interface; other site 167555000862 oxygen evolving complex binding site; other site 167555000863 bromide binding site; other site 167555000864 quinone binding site; other site 167555000865 Fe binding site [ion binding]; other site 167555000866 core light harvesting interface; other site 167555000867 cytochrome b559 alpha subunit interface; other site 167555000868 cytochrome c-550 interface; other site 167555000869 protein J interface; other site 167555000870 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 167555000871 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 167555000872 Tetramer interface [polypeptide binding]; other site 167555000873 active site 167555000874 FMN-binding site [chemical binding]; other site 167555000875 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 167555000876 active site 167555000877 intersubunit interface [polypeptide binding]; other site 167555000878 catalytic residue [active] 167555000879 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 167555000880 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167555000881 Walker A motif; other site 167555000882 ATP binding site [chemical binding]; other site 167555000883 Walker B motif; other site 167555000884 arginine finger; other site 167555000885 Peptidase family M41; Region: Peptidase_M41; pfam01434 167555000886 ATP sulphurylase; Region: sopT; TIGR00339 167555000887 ATP-sulfurylase; Region: ATPS; cd00517 167555000888 active site 167555000889 HXXH motif; other site 167555000890 flexible loop; other site 167555000891 Manganese-stabilising protein / photosystem II polypeptide; Region: MSP; cl03326 167555000892 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 167555000893 Flavoprotein; Region: Flavoprotein; pfam02441 167555000894 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 167555000895 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 167555000896 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 167555000897 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 167555000898 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 167555000899 active site 167555000900 DNA binding site [nucleotide binding] 167555000901 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 167555000902 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 167555000903 Beta-carotene hydroxylase (CrtR), the carotenoid zeaxanthin biosynthetic enzyme catalyzes the addition of hydroxyl groups to the beta-ionone rings of beta-carotene to form zeaxanthin and is found in bacteria and red algae. Carotenoids are important...; Region: CrtR_beta-carotene-hydroxylase; cd03514 167555000904 putative di-iron ligands [ion binding]; other site 167555000905 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 167555000906 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 167555000907 active site 167555000908 HIGH motif; other site 167555000909 nucleotide binding site [chemical binding]; other site 167555000910 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 167555000911 active site 167555000912 KMSKS motif; other site 167555000913 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 167555000914 tRNA binding surface [nucleotide binding]; other site 167555000915 anticodon binding site; other site 167555000916 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 167555000917 Protein of unknown function (DUF3177); Region: DUF3177; pfam11375 167555000918 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 167555000919 S-adenosylmethionine binding site [chemical binding]; other site 167555000920 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 167555000921 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 167555000922 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 167555000923 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 167555000924 trimer interface [polypeptide binding]; other site 167555000925 active site 167555000926 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; cl17276 167555000927 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 167555000928 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 167555000929 ligand binding site [chemical binding]; other site 167555000930 flexible hinge region; other site 167555000931 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 167555000932 putative switch regulator; other site 167555000933 non-specific DNA interactions [nucleotide binding]; other site 167555000934 DNA binding site [nucleotide binding] 167555000935 sequence specific DNA binding site [nucleotide binding]; other site 167555000936 putative cAMP binding site [chemical binding]; other site 167555000937 Protein of unknown function (DUF3084); Region: DUF3084; pfam11283 167555000938 Uncharacterized protein family (UPF0081); Region: UPF0081; cl17278 167555000939 Protein of unknown function (DUF3146); Region: DUF3146; pfam11344 167555000940 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 167555000941 putative active site [active] 167555000942 catalytic residue [active] 167555000943 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 167555000944 photosystem II reaction center protein H; Provisional; Region: psbH; PRK02624 167555000945 photosystem II reaction center I protein I; Provisional; Region: psbI; PRK02655 167555000946 Protein of unknown function (DUF3769); Region: DUF3769; pfam12600 167555000947 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 167555000948 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 167555000949 substrate binding site [chemical binding]; other site 167555000950 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 167555000951 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 167555000952 substrate binding site [chemical binding]; other site 167555000953 ligand binding site [chemical binding]; other site 167555000954 competence damage-inducible protein A; Provisional; Region: PRK00549 167555000955 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 167555000956 putative MPT binding site; other site 167555000957 Competence-damaged protein; Region: CinA; pfam02464 167555000958 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 167555000959 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 167555000960 dimer interface [polypeptide binding]; other site 167555000961 active site 167555000962 glycine-pyridoxal phosphate binding site [chemical binding]; other site 167555000963 folate binding site [chemical binding]; other site 167555000964 Protein of unknown function (DUF3181); Region: DUF3181; pfam11378 167555000965 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 167555000966 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 167555000967 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 167555000968 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Provisional; Region: PRK13371 167555000969 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 167555000970 DoxX; Region: DoxX; pfam07681 167555000971 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 167555000972 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 167555000973 purine monophosphate binding site [chemical binding]; other site 167555000974 dimer interface [polypeptide binding]; other site 167555000975 putative catalytic residues [active] 167555000976 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 167555000977 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 167555000978 putative hydrolase; Provisional; Region: PRK11460 167555000979 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 167555000980 Protein of unknown function (DUF3155); Region: DUF3155; pfam11352 167555000981 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 167555000982 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 167555000983 dimer interface [polypeptide binding]; other site 167555000984 phosphorylation site [posttranslational modification] 167555000985 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 167555000986 ATP binding site [chemical binding]; other site 167555000987 Mg2+ binding site [ion binding]; other site 167555000988 G-X-G motif; other site 167555000989 cobalamin synthase; Reviewed; Region: cobS; PRK00235 167555000990 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 167555000991 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 167555000992 Photosystem II 4 kDa reaction centre component; Region: PsbK; cl03641 167555000993 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 167555000994 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 167555000995 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 167555000996 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 167555000997 Domain of unknown function DUF21; Region: DUF21; pfam01595 167555000998 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 167555000999 Transporter associated domain; Region: CorC_HlyC; smart01091 167555001000 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 167555001001 active site 167555001002 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 167555001003 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 167555001004 RecB family nuclease, putative, TM0106 family; Region: TIGR03491 167555001005 RNase_H superfamily; Region: RNase_H_2; pfam13482 167555001006 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 167555001007 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 167555001008 active site 167555001009 substrate binding site [chemical binding]; other site 167555001010 metal binding site [ion binding]; metal-binding site 167555001011 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 167555001012 active site 167555001013 dimerization interface [polypeptide binding]; other site 167555001014 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 167555001015 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 167555001016 imidazoleglycerol-phosphate dehydratase; Region: PLN02800 167555001017 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 167555001018 putative active site pocket [active] 167555001019 4-fold oligomerization interface [polypeptide binding]; other site 167555001020 metal binding residues [ion binding]; metal-binding site 167555001021 3-fold/trimer interface [polypeptide binding]; other site 167555001022 enoyl-(acyl carrier protein) reductase; Validated; Region: PRK07370 167555001023 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 167555001024 NAD binding site [chemical binding]; other site 167555001025 homotetramer interface [polypeptide binding]; other site 167555001026 homodimer interface [polypeptide binding]; other site 167555001027 substrate binding site [chemical binding]; other site 167555001028 active site 167555001029 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 167555001030 putative catalytic residue [active] 167555001031 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 167555001032 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 167555001033 inhibitor-cofactor binding pocket; inhibition site 167555001034 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167555001035 catalytic residue [active] 167555001036 DNA photolyase; Region: DNA_photolyase; pfam00875 167555001037 deoxyribodipyrimidine photo-lyase, 8-HDF type; Region: photolyase_8HDF; TIGR03556 167555001038 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 167555001039 dimer interface [polypeptide binding]; other site 167555001040 ADP-ribose binding site [chemical binding]; other site 167555001041 active site 167555001042 nudix motif; other site 167555001043 metal binding site [ion binding]; metal-binding site 167555001044 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 167555001045 catalytic center binding site [active] 167555001046 ATP binding site [chemical binding]; other site 167555001047 magnesium chelatase ATPase subunit I; Region: BchI-ChlI; TIGR02030 167555001048 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 167555001049 metal ion-dependent adhesion site (MIDAS); other site 167555001050 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 167555001051 mce related protein; Region: MCE; pfam02470 167555001052 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 167555001053 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 167555001054 Walker A/P-loop; other site 167555001055 ATP binding site [chemical binding]; other site 167555001056 Q-loop/lid; other site 167555001057 ABC transporter signature motif; other site 167555001058 Walker B; other site 167555001059 D-loop; other site 167555001060 H-loop/switch region; other site 167555001061 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 167555001062 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 167555001063 phosphate binding site [ion binding]; other site 167555001064 putative substrate binding pocket [chemical binding]; other site 167555001065 dimer interface [polypeptide binding]; other site 167555001066 NADH dehydrogenase subunit J; Provisional; Region: PRK12494 167555001067 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 167555001068 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194 167555001069 NADH dehydrogenase subunit 3; Region: ndhC; CHL00022 167555001070 Rubredoxin [Energy production and conversion]; Region: COG1773 167555001071 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202 167555001072 iron binding site [ion binding]; other site 167555001073 Ycf48-like protein; Provisional; Region: PRK13684 167555001074 cytochrome b559 subunit alpha; Provisional; Region: psbE; PRK02557 167555001075 Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits; Region: Cytochrom_B559; pfam00283 167555001076 Lumenal portion of Cytochrome b559, alpha (gene psbE) subunit; Region: Cytochrom_B559a; pfam00284 167555001077 photosystem II reaction center L; Provisional; Region: psbL; PRK00753 167555001078 photosystem II reaction center protein J; Provisional; Region: PRK02565 167555001079 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 167555001080 pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169 167555001081 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 167555001082 dimerization interface [polypeptide binding]; other site 167555001083 putative ATP binding site [chemical binding]; other site 167555001084 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 167555001085 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 167555001086 active site 167555001087 NTP binding site [chemical binding]; other site 167555001088 metal binding triad [ion binding]; metal-binding site 167555001089 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 167555001090 Part of AAA domain; Region: AAA_19; pfam13245 167555001091 Family description; Region: UvrD_C_2; pfam13538 167555001092 Phycobilisome protein; Region: Phycobilisome; cl08227 167555001093 Phycobilisome protein; Region: Phycobilisome; cl08227 167555001094 HEAT repeats; Region: HEAT_2; pfam13646 167555001095 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 167555001096 HEAT repeats; Region: HEAT_2; pfam13646 167555001097 CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206 167555001098 CpeS-like protein; Region: CpeS; pfam09367 167555001099 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 167555001100 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 167555001101 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 167555001102 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 167555001103 NAD binding site [chemical binding]; other site 167555001104 putative substrate binding site 2 [chemical binding]; other site 167555001105 putative substrate binding site 1 [chemical binding]; other site 167555001106 active site 167555001107 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 167555001108 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 167555001109 putative NAD(P) binding site [chemical binding]; other site 167555001110 active site 167555001111 putative substrate binding site [chemical binding]; other site 167555001112 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 167555001113 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 167555001114 D-xylulose kinase; Region: XylB; TIGR01312 167555001115 nucleotide binding site [chemical binding]; other site 167555001116 S-adenosylmethionine synthetase; Validated; Region: PRK05250 167555001117 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 167555001118 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 167555001119 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 167555001120 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 167555001121 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 167555001122 active site 167555001123 motif I; other site 167555001124 motif II; other site 167555001125 30S ribosomal protein S1; Reviewed; Region: PRK07400 167555001126 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 167555001127 RNA binding site [nucleotide binding]; other site 167555001128 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 167555001129 RNA binding site [nucleotide binding]; other site 167555001130 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 167555001131 RNA binding site [nucleotide binding]; other site 167555001132 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 167555001133 ATP cone domain; Region: ATP-cone; pfam03477 167555001134 photosystem II reaction center protein T; Reviewed; Region: psbT; PRK11875 167555001135 photosystem II chlorophyll-binding protein CP47; Region: PS_II_CP47; TIGR03039 167555001136 photosystem II reaction center protein M; Provisional; Region: psbM; PRK14094 167555001137 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 167555001138 active site 167555001139 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 167555001140 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 167555001141 S-adenosylmethionine binding site [chemical binding]; other site 167555001142 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 167555001143 cell division topological specificity factor MinE; Provisional; Region: PRK13988 167555001144 septum site-determining protein MinD; Region: minD_bact; TIGR01968 167555001145 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 167555001146 P-loop; other site 167555001147 ADP binding residues [chemical binding]; other site 167555001148 Switch I; other site 167555001149 Switch II; other site 167555001150 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 167555001151 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 167555001152 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 167555001153 Zn2+ binding site [ion binding]; other site 167555001154 Mg2+ binding site [ion binding]; other site 167555001155 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 167555001156 C-terminal peptidase (prc); Region: prc; TIGR00225 167555001157 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 167555001158 protein binding site [polypeptide binding]; other site 167555001159 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 167555001160 Catalytic dyad [active] 167555001161 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 167555001162 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 167555001163 Qi binding site; other site 167555001164 intrachain domain interface; other site 167555001165 interchain domain interface [polypeptide binding]; other site 167555001166 heme bH binding site [chemical binding]; other site 167555001167 heme bL binding site [chemical binding]; other site 167555001168 Qo binding site; other site 167555001169 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 167555001170 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 167555001171 interchain domain interface [polypeptide binding]; other site 167555001172 intrachain domain interface; other site 167555001173 Qi binding site; other site 167555001174 Qo binding site; other site 167555001175 Alkaline and neutral invertase; Region: Glyco_hydro_100; pfam12899 167555001176 formamidopyrimidine-DNA glycosylase; Provisional; Region: PRK13945 167555001177 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 167555001178 DNA binding site [nucleotide binding] 167555001179 catalytic residue [active] 167555001180 H2TH interface [polypeptide binding]; other site 167555001181 putative catalytic residues [active] 167555001182 turnover-facilitating residue; other site 167555001183 intercalation triad [nucleotide binding]; other site 167555001184 8OG recognition residue [nucleotide binding]; other site 167555001185 putative reading head residues; other site 167555001186 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 167555001187 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 167555001188 photosystem I reaction center subunit IV; Provisional; Region: PRK02749 167555001189 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 167555001190 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 167555001191 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 167555001192 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 167555001193 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 167555001194 NAD(P) binding site [chemical binding]; other site 167555001195 catalytic residues [active] 167555001196 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 167555001197 Protein of unknown function (DUF1651); Region: DUF1651; pfam07864 167555001198 Protein of unknown function (DUF3804); Region: DUF3804; pfam12707 167555001199 putative high light inducible protein; Region: PHA02337 167555001200 putative high light inducible protein; Region: PHA02337 167555001201 putative high light inducible protein; Region: PHA02337 167555001202 putative high light inducible protein; Region: PHA02337 167555001203 putative high light inducible protein; Region: PHA02337 167555001204 Dehydroquinase class II; Region: DHquinase_II; pfam01220 167555001205 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 167555001206 trimer interface [polypeptide binding]; other site 167555001207 active site 167555001208 dimer interface [polypeptide binding]; other site 167555001209 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 167555001210 active site 167555001211 dinuclear metal binding site [ion binding]; other site 167555001212 dimerization interface [polypeptide binding]; other site 167555001213 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 167555001214 active site 167555001215 SAM binding site [chemical binding]; other site 167555001216 homodimer interface [polypeptide binding]; other site 167555001217 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 167555001218 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 167555001219 FMN binding site [chemical binding]; other site 167555001220 active site 167555001221 catalytic residues [active] 167555001222 substrate binding site [chemical binding]; other site 167555001223 GTP-binding protein Der; Reviewed; Region: PRK00093 167555001224 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 167555001225 G1 box; other site 167555001226 GTP/Mg2+ binding site [chemical binding]; other site 167555001227 Switch I region; other site 167555001228 G2 box; other site 167555001229 Switch II region; other site 167555001230 G3 box; other site 167555001231 G4 box; other site 167555001232 G5 box; other site 167555001233 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 167555001234 G1 box; other site 167555001235 GTP/Mg2+ binding site [chemical binding]; other site 167555001236 Switch I region; other site 167555001237 G2 box; other site 167555001238 G3 box; other site 167555001239 Switch II region; other site 167555001240 G4 box; other site 167555001241 G5 box; other site 167555001242 Cobalt transport protein; Region: CbiQ; cl00463 167555001243 Protein of unknown function (DUF3539); Region: DUF3539; pfam12058 167555001244 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 167555001245 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 167555001246 catalytic residue [active] 167555001247 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 167555001248 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 167555001249 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 167555001250 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 167555001251 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 167555001252 Recombination protein O N terminal; Region: RecO_N; pfam11967 167555001253 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 167555001254 Recombination protein O C terminal; Region: RecO_C; pfam02565 167555001255 Class I aldolases; Region: Aldolase_Class_I; cl17187 167555001256 catalytic residue [active] 167555001257 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 167555001258 30S subunit binding site; other site 167555001259 lipoate-protein ligase B; Provisional; Region: PRK14344 167555001260 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 167555001261 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 167555001262 acyl-activating enzyme (AAE) consensus motif; other site 167555001263 putative AMP binding site [chemical binding]; other site 167555001264 putative active site [active] 167555001265 putative CoA binding site [chemical binding]; other site 167555001266 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 167555001267 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 167555001268 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 167555001269 E3 interaction surface; other site 167555001270 lipoyl attachment site [posttranslational modification]; other site 167555001271 e3 binding domain; Region: E3_binding; pfam02817 167555001272 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 167555001273 Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547 167555001274 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 167555001275 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 167555001276 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 167555001277 dimer interface [polypeptide binding]; other site 167555001278 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167555001279 catalytic residue [active] 167555001280 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 167555001281 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 167555001282 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 167555001283 catalytic residue [active] 167555001284 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 167555001285 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 167555001286 homodimer interface [polypeptide binding]; other site 167555001287 substrate-cofactor binding pocket; other site 167555001288 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167555001289 catalytic residue [active] 167555001290 ribosomal protein S4; Reviewed; Region: rps4; CHL00113 167555001291 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 167555001292 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 167555001293 RNA binding surface [nucleotide binding]; other site 167555001294 Haemolytic domain; Region: Haemolytic; pfam01809 167555001295 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 167555001296 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 167555001297 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 167555001298 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 167555001299 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 167555001300 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 167555001301 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 167555001302 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 167555001303 catalytic residue [active] 167555001304 Photosystem II reaction centre N protein (psbN); Region: PsbN; cl03605 167555001305 High-affinity nickel-transport protein; Region: NicO; cl00964 167555001306 NifU-like domain; Region: NifU; pfam01106 167555001307 malate:quinone oxidoreductase; Validated; Region: PRK05257 167555001308 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 167555001309 GTP-binding protein LepA; Provisional; Region: PRK05433 167555001310 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 167555001311 G1 box; other site 167555001312 putative GEF interaction site [polypeptide binding]; other site 167555001313 GTP/Mg2+ binding site [chemical binding]; other site 167555001314 Switch I region; other site 167555001315 G2 box; other site 167555001316 G3 box; other site 167555001317 Switch II region; other site 167555001318 G4 box; other site 167555001319 G5 box; other site 167555001320 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 167555001321 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 167555001322 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 167555001323 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 167555001324 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 167555001325 dimer interface [polypeptide binding]; other site 167555001326 conserved gate region; other site 167555001327 ABC-ATPase subunit interface; other site 167555001328 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 167555001329 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 167555001330 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 167555001331 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 167555001332 16S rRNA methyltransferase B; Provisional; Region: PRK14901 167555001333 putative RNA binding site [nucleotide binding]; other site 167555001334 NusB family; Region: NusB; pfam01029 167555001335 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 167555001336 S-adenosylmethionine binding site [chemical binding]; other site 167555001337 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 167555001338 UbiA prenyltransferase family; Region: UbiA; pfam01040 167555001339 Protein of unknown function (DUF2862); Region: DUF2862; pfam11061 167555001340 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 167555001341 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 167555001342 substrate binding site [chemical binding]; other site 167555001343 glutamase interaction surface [polypeptide binding]; other site 167555001344 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 167555001345 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 167555001346 S-adenosylmethionine binding site [chemical binding]; other site 167555001347 Protein of unknown function (DUF721); Region: DUF721; pfam05258 167555001348 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 167555001349 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 167555001350 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 167555001351 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 167555001352 Walker A/P-loop; other site 167555001353 ATP binding site [chemical binding]; other site 167555001354 Q-loop/lid; other site 167555001355 ABC transporter signature motif; other site 167555001356 Walker B; other site 167555001357 D-loop; other site 167555001358 H-loop/switch region; other site 167555001359 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 167555001360 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 167555001361 active site 167555001362 interdomain interaction site; other site 167555001363 putative metal-binding site [ion binding]; other site 167555001364 nucleotide binding site [chemical binding]; other site 167555001365 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 167555001366 domain I; other site 167555001367 phosphate binding site [ion binding]; other site 167555001368 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 167555001369 domain II; other site 167555001370 domain III; other site 167555001371 nucleotide binding site [chemical binding]; other site 167555001372 DNA binding groove [nucleotide binding] 167555001373 catalytic site [active] 167555001374 domain IV; other site 167555001375 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 167555001376 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 167555001377 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 167555001378 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 167555001379 putative dimer interface [polypeptide binding]; other site 167555001380 active site pocket [active] 167555001381 putative cataytic base [active] 167555001382 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 167555001383 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 167555001384 Lumazine binding domain; Region: Lum_binding; pfam00677 167555001385 Lumazine binding domain; Region: Lum_binding; pfam00677 167555001386 AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250 167555001387 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 167555001388 Subunit I/III interface [polypeptide binding]; other site 167555001389 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 167555001390 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 167555001391 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 167555001392 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 167555001393 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 167555001394 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 167555001395 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 167555001396 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 167555001397 UbiA prenyltransferase family; Region: UbiA; pfam01040 167555001398 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 167555001399 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 167555001400 Walker A/P-loop; other site 167555001401 ATP binding site [chemical binding]; other site 167555001402 Q-loop/lid; other site 167555001403 ABC transporter signature motif; other site 167555001404 Walker B; other site 167555001405 D-loop; other site 167555001406 H-loop/switch region; other site 167555001407 ABC-2 type transporter; Region: ABC2_membrane; cl17235 167555001408 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 167555001409 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 167555001410 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 167555001411 ring oligomerisation interface [polypeptide binding]; other site 167555001412 ATP/Mg binding site [chemical binding]; other site 167555001413 stacking interactions; other site 167555001414 hinge regions; other site 167555001415 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 167555001416 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 167555001417 NAD(P) binding site [chemical binding]; other site 167555001418 homotetramer interface [polypeptide binding]; other site 167555001419 homodimer interface [polypeptide binding]; other site 167555001420 active site 167555001421 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 167555001422 substrate binding site; other site 167555001423 dimer interface; other site 167555001424 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 167555001425 dimer interface [polypeptide binding]; other site 167555001426 catalytic triad [active] 167555001427 prenyltransferase; Reviewed; Region: ubiA; PRK12873 167555001428 UbiA prenyltransferase family; Region: UbiA; pfam01040 167555001429 exopolyphosphatase; Region: exo_poly_only; TIGR03706 167555001430 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 167555001431 Helix-turn-helix domain; Region: HTH_25; pfam13413 167555001432 non-specific DNA binding site [nucleotide binding]; other site 167555001433 salt bridge; other site 167555001434 sequence-specific DNA binding site [nucleotide binding]; other site 167555001435 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 167555001436 active site 167555001437 SAM binding site [chemical binding]; other site 167555001438 homodimer interface [polypeptide binding]; other site 167555001439 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 167555001440 cytochrome f; Region: petA; CHL00037 167555001441 apocytochrome f; Reviewed; Region: PRK02693 167555001442 cytochrome b6-f complex iron-sulfur subunit; Provisional; Region: PRK13474 167555001443 Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802 167555001444 Iron-sulfur protein (ISP) component of the b6f complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The cytochrome b6f complex from Mastigocladus laminosus, a thermophilic cyanobacterium; Region: Rieske_cytochrome_b6f; cd03471 167555001445 cytochrome b subunit interaction site [polypeptide binding]; other site 167555001446 [2Fe-2S] cluster binding site [ion binding]; other site 167555001447 Protein of unknown function (DUF3067); Region: DUF3067; pfam11267 167555001448 Sec-independent translocase component C; Provisional; Region: tatC; CHL00182 167555001449 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 167555001450 Domain of unknown function (DUF814); Region: DUF814; pfam05670 167555001451 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 167555001452 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 167555001453 catalytic site [active] 167555001454 G-X2-G-X-G-K; other site 167555001455 photosystem I reaction center subunit IX; Provisional; Region: PRK02733 167555001456 Photosystem I reaction centre subunit III; Region: PSI_PsaF; cl03627 167555001457 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 167555001458 UGMP family protein; Validated; Region: PRK09604 167555001459 Protein of unknown function (DUF1643); Region: DUF1643; pfam07799 167555001460 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 167555001461 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 167555001462 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 167555001463 HIGH motif; other site 167555001464 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 167555001465 active site 167555001466 KMSKS motif; other site 167555001467 Src Homology 3 domain superfamily; Region: SH3; cl17036 167555001468 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 167555001469 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 167555001470 active site 167555001471 short chain dehydrogenase; Provisional; Region: PRK12367 167555001472 NAD(P) binding site [chemical binding]; other site 167555001473 BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857 167555001474 DRTGG domain; Region: DRTGG; pfam07085 167555001475 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 167555001476 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 167555001477 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 167555001478 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 167555001479 SPFH domain / Band 7 family; Region: Band_7; pfam01145 167555001480 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 167555001481 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 167555001482 inhibitor-cofactor binding pocket; inhibition site 167555001483 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167555001484 catalytic residue [active] 167555001485 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 167555001486 putative catalytic site [active] 167555001487 putative phosphate binding site [ion binding]; other site 167555001488 active site 167555001489 metal binding site A [ion binding]; metal-binding site 167555001490 DNA binding site [nucleotide binding] 167555001491 putative AP binding site [nucleotide binding]; other site 167555001492 putative metal binding site B [ion binding]; other site 167555001493 hypothetical protein; Provisional; Region: PRK04194 167555001494 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 167555001495 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 167555001496 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 167555001497 dimer interface [polypeptide binding]; other site 167555001498 conserved gate region; other site 167555001499 putative PBP binding loops; other site 167555001500 ABC-ATPase subunit interface; other site 167555001501 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 167555001502 dimer interface [polypeptide binding]; other site 167555001503 conserved gate region; other site 167555001504 putative PBP binding loops; other site 167555001505 ABC-ATPase subunit interface; other site 167555001506 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 167555001507 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 167555001508 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 167555001509 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914 167555001510 aromatic arch; other site 167555001511 DCoH dimer interaction site [polypeptide binding]; other site 167555001512 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 167555001513 DCoH tetramer interaction site [polypeptide binding]; other site 167555001514 substrate binding site [chemical binding]; other site 167555001515 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 167555001516 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 167555001517 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 167555001518 active site 167555001519 Zn binding site [ion binding]; other site 167555001520 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 167555001521 dimer interface [polypeptide binding]; other site 167555001522 substrate binding site [chemical binding]; other site 167555001523 metal binding sites [ion binding]; metal-binding site 167555001524 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 167555001525 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 167555001526 domain interfaces; other site 167555001527 active site 167555001528 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 167555001529 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 167555001530 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 167555001531 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 167555001532 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 167555001533 DNA binding residues [nucleotide binding] 167555001534 primosome assembly protein PriA; Validated; Region: PRK05580 167555001535 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 167555001536 ATP binding site [chemical binding]; other site 167555001537 putative Mg++ binding site [ion binding]; other site 167555001538 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 167555001539 ATP-binding site [chemical binding]; other site 167555001540 Protein of unknown function (DUF3153); Region: DUF3153; pfam11353 167555001541 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 167555001542 feedback inhibition sensing region; other site 167555001543 homohexameric interface [polypeptide binding]; other site 167555001544 nucleotide binding site [chemical binding]; other site 167555001545 N-acetyl-L-glutamate binding site [chemical binding]; other site 167555001546 Protein of unknown function (DUF2854); Region: DUF2854; pfam11016 167555001547 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 167555001548 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 167555001549 ssDNA binding site [nucleotide binding]; other site 167555001550 dimer interface [polypeptide binding]; other site 167555001551 tetramer (dimer of dimers) interface [polypeptide binding]; other site 167555001552 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 167555001553 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 167555001554 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 167555001555 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 167555001556 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 167555001557 substrate binding site [chemical binding]; other site 167555001558 ATP binding site [chemical binding]; other site 167555001559 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 167555001560 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 167555001561 GDP-binding site [chemical binding]; other site 167555001562 ACT binding site; other site 167555001563 IMP binding site; other site 167555001564 photosystem II protein Psb27; Region: PS_II_psb27; TIGR03044 167555001565 prolyl-tRNA synthetase; Provisional; Region: PRK09194 167555001566 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 167555001567 motif 1; other site 167555001568 dimer interface [polypeptide binding]; other site 167555001569 active site 167555001570 motif 2; other site 167555001571 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 167555001572 putative deacylase active site [active] 167555001573 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 167555001574 active site 167555001575 motif 3; other site 167555001576 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 167555001577 anticodon binding site; other site 167555001578 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 167555001579 dimer interface [polypeptide binding]; other site 167555001580 substrate binding site [chemical binding]; other site 167555001581 metal binding sites [ion binding]; metal-binding site 167555001582 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 167555001583 ArsC family; Region: ArsC; pfam03960 167555001584 putative ArsC-like catalytic residues; other site 167555001585 putative TRX-like catalytic residues [active] 167555001586 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 167555001587 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 167555001588 Catalytic site [active] 167555001589 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 167555001590 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 167555001591 catalytic core [active] 167555001592 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 167555001593 catalytic core [active] 167555001594 CAAX protease self-immunity; Region: Abi; pfam02517 167555001595 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 167555001596 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 167555001597 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 167555001598 transaldolase-like protein; Provisional; Region: PTZ00411 167555001599 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 167555001600 active site 167555001601 dimer interface [polypeptide binding]; other site 167555001602 catalytic residue [active] 167555001603 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 167555001604 ribosome recycling factor; Reviewed; Region: frr; PRK00083 167555001605 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 167555001606 hinge region; other site 167555001607 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 167555001608 putative nucleotide binding site [chemical binding]; other site 167555001609 uridine monophosphate binding site [chemical binding]; other site 167555001610 homohexameric interface [polypeptide binding]; other site 167555001611 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 167555001612 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 167555001613 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 167555001614 homodimer interface [polypeptide binding]; other site 167555001615 Walker A motif; other site 167555001616 ATP binding site [chemical binding]; other site 167555001617 hydroxycobalamin binding site [chemical binding]; other site 167555001618 Walker B motif; other site 167555001619 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 167555001620 active site 167555001621 catalytic residues [active] 167555001622 DNA binding site [nucleotide binding] 167555001623 Int/Topo IB signature motif; other site 167555001624 ferrochelatase; Reviewed; Region: hemH; PRK00035 167555001625 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 167555001626 C-terminal domain interface [polypeptide binding]; other site 167555001627 active site 167555001628 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 167555001629 active site 167555001630 N-terminal domain interface [polypeptide binding]; other site 167555001631 acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK07418 167555001632 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 167555001633 PYR/PP interface [polypeptide binding]; other site 167555001634 dimer interface [polypeptide binding]; other site 167555001635 TPP binding site [chemical binding]; other site 167555001636 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 167555001637 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 167555001638 TPP-binding site [chemical binding]; other site 167555001639 dimer interface [polypeptide binding]; other site 167555001640 Protein of unknown function (DUF1092); Region: DUF1092; pfam06485 167555001641 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 167555001642 RNA binding site [nucleotide binding]; other site 167555001643 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 167555001644 RNA binding site [nucleotide binding]; other site 167555001645 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 167555001646 RNA binding site [nucleotide binding]; other site 167555001647 Creatinine amidohydrolase; Region: Creatininase; pfam02633 167555001648 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 167555001649 dinuclear metal binding motif [ion binding]; other site 167555001650 acyl-ACP reductase; Provisional; Region: PRK14982 167555001651 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 167555001652 NAD(P) binding pocket [chemical binding]; other site 167555001653 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 167555001654 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 167555001655 short chain dehydrogenase; Provisional; Region: PRK07454 167555001656 classical (c) SDRs; Region: SDR_c; cd05233 167555001657 NAD(P) binding site [chemical binding]; other site 167555001658 active site 167555001659 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 167555001660 active site 167555001661 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 167555001662 active site 167555001663 Peptidase family M50; Region: Peptidase_M50; pfam02163 167555001664 putative substrate binding region [chemical binding]; other site 167555001665 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 167555001666 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 167555001667 protochlorophyllide oxidoreductase; Validated; Region: PRK07453 167555001668 light-dependent protochlorophyllide reductase; Region: LPOR; TIGR01289 167555001669 NAD(P) binding site [chemical binding]; other site 167555001670 active site 167555001671 protochlorophyllide reductase iron-sulfur ATP-binding protein; Provisional; Region: chlL; PRK13185 167555001672 This family of proteins contains bchL and chlL. Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. Three genes, bchL, bchN and bchB, are...; Region: Bchl_like; cd02032 167555001673 P-loop; other site 167555001674 light-independent protochlorophyllide reductase subunit N; Provisional; Region: PRK02842 167555001675 light-independent protochlorophyllide reductase, N subunit; Region: DPOR_bchN; TIGR01279 167555001676 light-independent protochlorophyllide reductase subunit B; Provisional; Region: PRK02910 167555001677 Pchlide_reductase_B: B protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_B; cd01981 167555001678 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 167555001679 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 1; Region: BMC_like_1_repeat1; cd07051 167555001680 putative hexamer interface [polypeptide binding]; other site 167555001681 putative hexagonal pore; other site 167555001682 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 2; Region: BMC_like_1_repeat2; cd07052 167555001683 putative hexamer interface [polypeptide binding]; other site 167555001684 putative hexagonal pore; other site 167555001685 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 167555001686 active site 167555001687 dimerization interface [polypeptide binding]; other site 167555001688 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 167555001689 Carboxysome Shell 1 (CsoS1); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CsoS1; cd07058 167555001690 Hexamer interface [polypeptide binding]; other site 167555001691 Hexagonal pore residue; other site 167555001692 Hexagonal pore; other site 167555001693 ribulose bisophosphate carboxylase; Reviewed; Region: rbcL; PRK04208 167555001694 Ribulose bisphosphate carboxylase large chain; Region: RuBisCO_large; cl08232 167555001695 dimer interface [polypeptide binding]; other site 167555001696 catalytic residue [active] 167555001697 metal binding site [ion binding]; metal-binding site 167555001698 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527 167555001699 multimerization interface [polypeptide binding]; other site 167555001700 Carboxysome shell peptide mid-region; Region: CsoS2_M; pfam12288 167555001701 Carboxysome shell peptide mid-region; Region: CsoS2_M; pfam12288 167555001702 Carboxysome Shell Carbonic Anhydrase; Region: CsoSCA; pfam08936 167555001703 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 167555001704 Hexamer/Pentamer interface [polypeptide binding]; other site 167555001705 central pore; other site 167555001706 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 167555001707 Hexamer/Pentamer interface [polypeptide binding]; other site 167555001708 central pore; other site 167555001709 Carboxysome Shell 1 (CsoS1); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CsoS1; cd07058 167555001710 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 167555001711 Hexamer interface [polypeptide binding]; other site 167555001712 Hexagonal pore residue; other site 167555001713 Hexagonal pore; other site 167555001714 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cl00942 167555001715 aromatic arch; other site 167555001716 DCoH dimer interaction site [polypeptide binding]; other site 167555001717 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 167555001718 DCoH tetramer interaction site [polypeptide binding]; other site 167555001719 substrate binding site [chemical binding]; other site 167555001720 Protein of unknown function (DUF3136); Region: DUF3136; pfam11334 167555001721 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 167555001722 homotrimer interaction site [polypeptide binding]; other site 167555001723 putative active site [active] 167555001724 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 167555001725 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 167555001726 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 167555001727 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 167555001728 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 167555001729 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 167555001730 Walker A/P-loop; other site 167555001731 ATP binding site [chemical binding]; other site 167555001732 Q-loop/lid; other site 167555001733 ABC transporter signature motif; other site 167555001734 Walker B; other site 167555001735 D-loop; other site 167555001736 H-loop/switch region; other site 167555001737 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 167555001738 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 167555001739 Coenzyme A binding pocket [chemical binding]; other site 167555001740 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 167555001741 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 167555001742 Probable Catalytic site; other site 167555001743 transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282 167555001744 DnaA N-terminal domain; Region: DnaA_N; pfam11638 167555001745 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 167555001746 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167555001747 Walker A motif; other site 167555001748 ATP binding site [chemical binding]; other site 167555001749 Walker B motif; other site 167555001750 arginine finger; other site 167555001751 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 167555001752 DnaA box-binding interface [nucleotide binding]; other site 167555001753 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 167555001754 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 167555001755 C-terminal domain interface [polypeptide binding]; other site 167555001756 GSH binding site (G-site) [chemical binding]; other site 167555001757 dimer interface [polypeptide binding]; other site 167555001758 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 167555001759 N-terminal domain interface [polypeptide binding]; other site 167555001760 dimer interface [polypeptide binding]; other site 167555001761 substrate binding pocket (H-site) [chemical binding]; other site 167555001762 glutathione reductase; Validated; Region: PRK06116 167555001763 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 167555001764 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 167555001765 K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367 167555001766 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 167555001767 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 167555001768 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 167555001769 active site 167555001770 substrate binding pocket [chemical binding]; other site 167555001771 dimer interface [polypeptide binding]; other site 167555001772 NADH dehydrogenase transmembrane subunit; Region: NdhL; pfam10716 167555001773 Protein of unknown function (DUF3007); Region: DUF3007; pfam11460 167555001774 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 167555001775 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 167555001776 substrate binding site [chemical binding]; other site 167555001777 active site 167555001778 catalytic residues [active] 167555001779 heterodimer interface [polypeptide binding]; other site 167555001780 YciI-like protein; Reviewed; Region: PRK12864 167555001781 Cytochrome c; Region: Cytochrom_C; cl11414 167555001782 D-xylulose kinase; Region: XylB; TIGR01312 167555001783 Uncharacterized conserved protein [Function unknown]; Region: COG3339 167555001784 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 167555001785 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 167555001786 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 167555001787 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 167555001788 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 167555001789 DNA binding residues [nucleotide binding] 167555001790 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 167555001791 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 167555001792 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 167555001793 metal binding site [ion binding]; metal-binding site 167555001794 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 167555001795 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 167555001796 Clp amino terminal domain; Region: Clp_N; pfam02861 167555001797 Clp amino terminal domain; Region: Clp_N; pfam02861 167555001798 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167555001799 Walker A motif; other site 167555001800 ATP binding site [chemical binding]; other site 167555001801 Walker B motif; other site 167555001802 arginine finger; other site 167555001803 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167555001804 Walker A motif; other site 167555001805 ATP binding site [chemical binding]; other site 167555001806 Walker B motif; other site 167555001807 arginine finger; other site 167555001808 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 167555001809 plastocyanin; Provisional; Region: PRK02710 167555001810 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 167555001811 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167555001812 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 167555001813 NAD(P) binding site [chemical binding]; other site 167555001814 active site 167555001815 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 167555001816 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 167555001817 substrate binding site [chemical binding]; other site 167555001818 active site 167555001819 glycogen branching enzyme; Provisional; Region: PRK05402 167555001820 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 167555001821 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 167555001822 active site 167555001823 catalytic site [active] 167555001824 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 167555001825 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 167555001826 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 167555001827 Domain of unknown function (DUF4332); Region: DUF4332; pfam14229 167555001828 Protein of function (DUF2518); Region: DUF2518; pfam10726 167555001829 Family of unknown function (DUF490); Region: DUF490; pfam04357 167555001830 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 167555001831 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 167555001832 putative catalytic cysteine [active] 167555001833 Dihydroneopterin aldolase; Region: FolB; smart00905 167555001834 active site 167555001835 Lipase (class 2); Region: Lipase_2; pfam01674 167555001836 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 167555001837 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 167555001838 active site 167555001839 Zn binding site [ion binding]; other site 167555001840 NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK12561 167555001841 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 167555001842 homoserine kinase; Provisional; Region: PRK01212 167555001843 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 167555001844 Glucokinase; Region: Glucokinase; pfam02685 167555001845 glucokinase, proteobacterial type; Region: glk; TIGR00749 167555001846 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 167555001847 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 167555001848 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 167555001849 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 167555001850 active site 167555001851 dimer interface [polypeptide binding]; other site 167555001852 motif 1; other site 167555001853 motif 2; other site 167555001854 motif 3; other site 167555001855 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 167555001856 anticodon binding site; other site 167555001857 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 167555001858 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 167555001859 active site 167555001860 HIGH motif; other site 167555001861 dimer interface [polypeptide binding]; other site 167555001862 KMSKS motif; other site 167555001863 Domain of unknown function (DUF697); Region: DUF697; pfam05128 167555001864 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 167555001865 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 167555001866 metal binding site [ion binding]; metal-binding site 167555001867 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 167555001868 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 167555001869 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 167555001870 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 167555001871 ABC-ATPase subunit interface; other site 167555001872 dimer interface [polypeptide binding]; other site 167555001873 putative PBP binding regions; other site 167555001874 Domain of unknown function (DUF4336); Region: DUF4336; pfam14234 167555001875 Protein of unknown function (DUF760); Region: DUF760; pfam05542 167555001876 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 167555001877 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 167555001878 Catalytic site [active] 167555001879 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase; Region: menD; TIGR00173 167555001880 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 167555001881 dimer interface [polypeptide binding]; other site 167555001882 tetramer interface [polypeptide binding]; other site 167555001883 PYR/PP interface [polypeptide binding]; other site 167555001884 TPP binding site [chemical binding]; other site 167555001885 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 167555001886 TPP-binding site; other site 167555001887 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 167555001888 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 167555001889 substrate binding site [chemical binding]; other site 167555001890 oxyanion hole (OAH) forming residues; other site 167555001891 trimer interface [polypeptide binding]; other site 167555001892 glycogen synthase; Provisional; Region: glgA; PRK00654 167555001893 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 167555001894 ADP-binding pocket [chemical binding]; other site 167555001895 homodimer interface [polypeptide binding]; other site 167555001896 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 167555001897 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 167555001898 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 167555001899 S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; cl17711 167555001900 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 167555001901 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 167555001902 hinge; other site 167555001903 active site 167555001904 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 167555001905 2-phosphosulfolactate phosphatase; Provisional; Region: PRK00886 167555001906 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 167555001907 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 167555001908 nitrilase; Region: PLN02798 167555001909 putative active site [active] 167555001910 catalytic triad [active] 167555001911 dimer interface [polypeptide binding]; other site 167555001912 AMIN domain; Region: AMIN; pfam11741 167555001913 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 167555001914 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 167555001915 active site 167555001916 metal binding site [ion binding]; metal-binding site 167555001917 glutamate racemase; Provisional; Region: PRK00865 167555001918 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 167555001919 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 167555001920 substrate binding pocket [chemical binding]; other site 167555001921 chain length determination region; other site 167555001922 substrate-Mg2+ binding site; other site 167555001923 catalytic residues [active] 167555001924 aspartate-rich region 1; other site 167555001925 active site lid residues [active] 167555001926 aspartate-rich region 2; other site 167555001927 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 167555001928 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 167555001929 active site 167555001930 motif I; other site 167555001931 motif II; other site 167555001932 acetyl-CoA synthetase; Provisional; Region: PRK00174 167555001933 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 167555001934 active site 167555001935 CoA binding site [chemical binding]; other site 167555001936 acyl-activating enzyme (AAE) consensus motif; other site 167555001937 AMP binding site [chemical binding]; other site 167555001938 acetate binding site [chemical binding]; other site 167555001939 Protein of unknown function (DUF1350); Region: DUF1350; pfam07082 167555001940 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 167555001941 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 167555001942 active site 167555001943 catalytic site [active] 167555001944 substrate binding site [chemical binding]; other site 167555001945 histidyl-tRNA synthetase; Region: hisS; TIGR00442 167555001946 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 167555001947 dimer interface [polypeptide binding]; other site 167555001948 motif 1; other site 167555001949 active site 167555001950 motif 2; other site 167555001951 motif 3; other site 167555001952 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 167555001953 anticodon binding site; other site 167555001954 probable UDP-glucose 6-dehydrogenase; Region: PLN02353 167555001955 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 167555001956 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 167555001957 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 167555001958 Tryptophan-rich protein (DUF2389); Region: DUF2389; pfam09493 167555001959 chlorophyll a/b binding light-harvesting protein; Region: PS_antenn_a_b; TIGR03041 167555001960 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 167555001961 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 167555001962 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 167555001963 C-terminal, alpha helical domain of an unknown subfamily 5 of Glutathione S-transferases; Region: GST_C_5; cd03196 167555001964 putative N-terminal domain interface [polypeptide binding]; other site 167555001965 putative dimer interface [polypeptide binding]; other site 167555001966 putative substrate binding pocket (H-site) [chemical binding]; other site 167555001967 This entry represents the putative helicase A859L; Region: T5orf172; smart00974 167555001968 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167555001969 short chain dehydrogenase; Provisional; Region: PRK07326 167555001970 NAD(P) binding site [chemical binding]; other site 167555001971 active site 167555001972 lycopene cyclase family protein; Region: carotene-cycl; TIGR01790 167555001973 lycopene cyclase; Region: lycopene_cycl; TIGR01789 167555001974 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167555001975 NAD(P) binding site [chemical binding]; other site 167555001976 active site 167555001977 Mechanosensitive ion channel; Region: MS_channel; pfam00924 167555001978 Isochorismatase family; Region: Isochorismatase; pfam00857 167555001979 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 167555001980 catalytic triad [active] 167555001981 dimer interface [polypeptide binding]; other site 167555001982 conserved cis-peptide bond; other site 167555001983 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 167555001984 metal binding site 2 [ion binding]; metal-binding site 167555001985 putative DNA binding helix; other site 167555001986 metal binding site 1 [ion binding]; metal-binding site 167555001987 structural Zn2+ binding site [ion binding]; other site 167555001988 radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167 167555001989 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 167555001990 FeS/SAM binding site; other site 167555001991 Protein of unknown function (DUF3641); Region: DUF3641; pfam12345 167555001992 glucosylglycerol 3-phosphatase; Region: salt_tol_Pase; TIGR02399 167555001993 Glucosylglycerol-phosphate phosphatase (Salt_tol_Pase); Region: Salt_tol_Pase; pfam09506 167555001994 Phosphotransferase enzyme family; Region: APH; pfam01636 167555001995 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 167555001996 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 167555001997 homodimer interface [polypeptide binding]; other site 167555001998 substrate-cofactor binding pocket; other site 167555001999 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167555002000 catalytic residue [active] 167555002001 Homoserine O-succinyltransferase; Region: HTS; pfam04204 167555002002 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 167555002003 proposed active site lysine [active] 167555002004 conserved cys residue [active] 167555002005 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 167555002006 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 167555002007 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 167555002008 putative active site [active] 167555002009 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 167555002010 putative active site [active] 167555002011 Protein of unknown function (DUF2811); Region: DUF2811; pfam10929 167555002012 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 167555002013 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 167555002014 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 167555002015 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 167555002016 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 167555002017 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 167555002018 Protein of unknown function (DUF1662); Region: DUF1662; pfam07878 167555002019 ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent; Region: RTPR; TIGR02505 167555002020 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 167555002021 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 167555002022 S-adenosylmethionine binding site [chemical binding]; other site 167555002023 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 167555002024 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 167555002025 G1 box; other site 167555002026 putative GEF interaction site [polypeptide binding]; other site 167555002027 GTP/Mg2+ binding site [chemical binding]; other site 167555002028 Switch I region; other site 167555002029 G2 box; other site 167555002030 G3 box; other site 167555002031 Switch II region; other site 167555002032 G4 box; other site 167555002033 G5 box; other site 167555002034 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 167555002035 Protein of unknown function (DUF3353); Region: DUF3353; pfam11833 167555002036 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 167555002037 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 167555002038 dimerization interface [polypeptide binding]; other site 167555002039 domain crossover interface; other site 167555002040 redox-dependent activation switch; other site 167555002041 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 167555002042 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 167555002043 Walker A/P-loop; other site 167555002044 ATP binding site [chemical binding]; other site 167555002045 Q-loop/lid; other site 167555002046 ABC transporter signature motif; other site 167555002047 Walker B; other site 167555002048 D-loop; other site 167555002049 H-loop/switch region; other site 167555002050 Protein of unknown function (DUF3531); Region: DUF3531; pfam12049 167555002051 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 167555002052 Integral membrane protein DUF92; Region: DUF92; pfam01940 167555002053 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_3; cd01835 167555002054 active site 167555002055 catalytic triad [active] 167555002056 oxyanion hole [active] 167555002057 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 167555002058 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 167555002059 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 167555002060 Walker A/P-loop; other site 167555002061 ATP binding site [chemical binding]; other site 167555002062 Q-loop/lid; other site 167555002063 ABC transporter signature motif; other site 167555002064 Walker B; other site 167555002065 D-loop; other site 167555002066 H-loop/switch region; other site 167555002067 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 167555002068 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 167555002069 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 167555002070 aspartate aminotransferase; Provisional; Region: PRK05764 167555002071 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 167555002072 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167555002073 homodimer interface [polypeptide binding]; other site 167555002074 catalytic residue [active] 167555002075 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 167555002076 Fe-S cluster binding site [ion binding]; other site 167555002077 active site 167555002078 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 167555002079 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 167555002080 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 167555002081 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 167555002082 C-terminal peptidase (prc); Region: prc; TIGR00225 167555002083 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 167555002084 protein binding site [polypeptide binding]; other site 167555002085 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 167555002086 Catalytic dyad [active] 167555002087 Domain of Unknown Function (DUF1543); Region: DUF1543; pfam07566 167555002088 quinolinate synthetase; Provisional; Region: PRK09375 167555002089 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 167555002090 TIGR04168 family protein; Region: TIGR04168 167555002091 Repair protein; Region: Repair_PSII; pfam04536 167555002092 Uncharacterized conserved protein [Function unknown]; Region: COG1565 167555002093 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 167555002094 active site 167555002095 dimer interface [polypeptide binding]; other site 167555002096 metal binding site [ion binding]; metal-binding site 167555002097 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 167555002098 ATP-grasp domain; Region: ATP-grasp_4; cl17255 167555002099 Domain of unknown function (DUF1824); Region: DUF1824; pfam08854 167555002100 Protein of unknown function (DUF1651); Region: DUF1651; pfam07864 167555002101 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 167555002102 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246 167555002103 Spondin_N; Region: Spond_N; pfam06468 167555002104 flavoprotein, HI0933 family; Region: TIGR00275 167555002105 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 167555002106 Predicted membrane protein [Function unknown]; Region: COG2259 167555002107 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 167555002108 Domain of unknown function DUF20; Region: UPF0118; pfam01594 167555002109 photosystem II reaction center protein Psb28; Provisional; Region: PRK13610 167555002110 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 167555002111 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 167555002112 active site residue [active] 167555002113 GUN4-like; Region: GUN4; pfam05419 167555002114 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 167555002115 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 167555002116 Methyltransferase domain; Region: Methyltransf_23; pfam13489 167555002117 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 167555002118 S-adenosylmethionine binding site [chemical binding]; other site 167555002119 glutamine synthetase, type I; Region: GlnA; TIGR00653 167555002120 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 167555002121 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 167555002122 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 167555002123 homodimer interface [polypeptide binding]; other site 167555002124 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167555002125 catalytic residue [active] 167555002126 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 167555002127 nucleoside/Zn binding site; other site 167555002128 dimer interface [polypeptide binding]; other site 167555002129 catalytic motif [active] 167555002130 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 167555002131 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 167555002132 catalytic residue [active] 167555002133 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 167555002134 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 167555002135 G1 box; other site 167555002136 GTP/Mg2+ binding site [chemical binding]; other site 167555002137 Switch I region; other site 167555002138 G2 box; other site 167555002139 Switch II region; other site 167555002140 G3 box; other site 167555002141 G4 box; other site 167555002142 G5 box; other site 167555002143 Domain of unknown function (DUF697); Region: DUF697; pfam05128 167555002144 lipoprotein signal peptidase; Provisional; Region: PRK14792 167555002145 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 167555002146 Protein of unknown function (DUF3148); Region: DUF3148; pfam11347 167555002147 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 167555002148 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 167555002149 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 167555002150 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 167555002151 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 167555002152 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 167555002153 phycocyanobilin:ferredoxin oxidoreductase; Validated; Region: PRK02816 167555002154 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 167555002155 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 167555002156 HlyD family secretion protein; Region: HlyD_3; pfam13437 167555002157 DevC protein; Region: devC; TIGR01185 167555002158 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 167555002159 FtsX-like permease family; Region: FtsX; pfam02687 167555002160 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 167555002161 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 167555002162 Walker A/P-loop; other site 167555002163 ATP binding site [chemical binding]; other site 167555002164 Q-loop/lid; other site 167555002165 ABC transporter signature motif; other site 167555002166 Walker B; other site 167555002167 D-loop; other site 167555002168 H-loop/switch region; other site 167555002169 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 167555002170 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 167555002171 Probable Catalytic site; other site 167555002172 metal-binding site 167555002173 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 167555002174 rRNA interaction site [nucleotide binding]; other site 167555002175 S8 interaction site; other site 167555002176 putative laminin-1 binding site; other site 167555002177 elongation factor Ts; Reviewed; Region: tsf; PRK12332 167555002178 UBA/TS-N domain; Region: UBA; pfam00627 167555002179 Elongation factor TS; Region: EF_TS; pfam00889 167555002180 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 167555002181 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 167555002182 generic binding surface II; other site 167555002183 ssDNA binding site; other site 167555002184 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 167555002185 ATP binding site [chemical binding]; other site 167555002186 putative Mg++ binding site [ion binding]; other site 167555002187 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 167555002188 nucleotide binding region [chemical binding]; other site 167555002189 ATP-binding site [chemical binding]; other site 167555002190 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 167555002191 sulfite reductase subunit beta; Provisional; Region: PRK13504 167555002192 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 167555002193 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 167555002194 Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092 167555002195 geranylgeranyl reductase; Region: ChlP; TIGR02028 167555002196 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 167555002197 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 167555002198 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 167555002199 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 167555002200 G1 box; other site 167555002201 putative GEF interaction site [polypeptide binding]; other site 167555002202 GTP/Mg2+ binding site [chemical binding]; other site 167555002203 Switch I region; other site 167555002204 G2 box; other site 167555002205 G3 box; other site 167555002206 Switch II region; other site 167555002207 G4 box; other site 167555002208 G5 box; other site 167555002209 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 167555002210 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 167555002211 Domain of unknown function (DUF309); Region: DUF309; pfam03745 167555002212 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 167555002213 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 167555002214 Walker A/P-loop; other site 167555002215 ATP binding site [chemical binding]; other site 167555002216 Q-loop/lid; other site 167555002217 ABC transporter signature motif; other site 167555002218 Walker B; other site 167555002219 D-loop; other site 167555002220 H-loop/switch region; other site 167555002221 Predicted permeases [General function prediction only]; Region: COG0795 167555002222 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 167555002223 cytochrome c biogenesis protein; Region: ccsA; CHL00045 167555002224 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 167555002225 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 167555002226 substrate binding site [chemical binding]; other site 167555002227 hexamer interface [polypeptide binding]; other site 167555002228 metal binding site [ion binding]; metal-binding site 167555002229 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 167555002230 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 167555002231 putative active site [active] 167555002232 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 167555002233 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 167555002234 tRNA; other site 167555002235 putative tRNA binding site [nucleotide binding]; other site 167555002236 putative NADP binding site [chemical binding]; other site 167555002237 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 167555002238 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862 167555002239 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 167555002240 ligand binding site; other site 167555002241 oligomer interface; other site 167555002242 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 167555002243 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 167555002244 dimer interface [polypeptide binding]; other site 167555002245 N-terminal domain interface [polypeptide binding]; other site 167555002246 sulfate 1 binding site; other site 167555002247 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 167555002248 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 167555002249 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 167555002250 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 167555002251 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 167555002252 putative active site [active] 167555002253 Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547 167555002254 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 167555002255 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 167555002256 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 167555002257 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 167555002258 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 167555002259 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 167555002260 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 167555002261 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 167555002262 chaperone protein DnaJ; Provisional; Region: PRK14291 167555002263 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 167555002264 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 167555002265 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 167555002266 putative active site [active] 167555002267 catalytic triad [active] 167555002268 Fructose-1,6-bisphosphate aldolase; Region: FBP_aldolase_I_a; cd00948 167555002269 active site 167555002270 intersubunit interface [polypeptide binding]; other site 167555002271 catalytic residue [active] 167555002272 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 167555002273 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 167555002274 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 167555002275 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 167555002276 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 167555002277 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 167555002278 Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029 167555002279 active site 167555002280 tartrate dehydrogenase; Region: TTC; TIGR02089 167555002281 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 167555002282 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 167555002283 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 167555002284 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 167555002285 trimer interface [polypeptide binding]; other site 167555002286 active site 167555002287 UDP-GlcNAc binding site [chemical binding]; other site 167555002288 lipid binding site [chemical binding]; lipid-binding site 167555002289 gamma-glutamyl kinase; Provisional; Region: PRK05429 167555002290 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 167555002291 nucleotide binding site [chemical binding]; other site 167555002292 homotetrameric interface [polypeptide binding]; other site 167555002293 putative phosphate binding site [ion binding]; other site 167555002294 putative allosteric binding site; other site 167555002295 PUA domain; Region: PUA; pfam01472 167555002296 Protein of unknown function (DUF3727); Region: DUF3727; pfam12527 167555002297 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 167555002298 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996 167555002299 Protein of unknown function (DUF3685); Region: DUF3685; pfam12452 167555002300 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 167555002301 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 167555002302 catalytic residues [active] 167555002303 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 167555002304 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167555002305 NAD(P) binding site [chemical binding]; other site 167555002306 active site 167555002307 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 167555002308 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 167555002309 Coenzyme A binding pocket [chemical binding]; other site 167555002310 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 167555002311 NADH(P)-binding; Region: NAD_binding_10; pfam13460 167555002312 NAD(P) binding site [chemical binding]; other site 167555002313 putative active site [active] 167555002314 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 167555002315 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 167555002316 minor groove reading motif; other site 167555002317 helix-hairpin-helix signature motif; other site 167555002318 substrate binding pocket [chemical binding]; other site 167555002319 active site 167555002320 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 167555002321 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 167555002322 Walker A/P-loop; other site 167555002323 ATP binding site [chemical binding]; other site 167555002324 Q-loop/lid; other site 167555002325 ABC transporter signature motif; other site 167555002326 Walker B; other site 167555002327 D-loop; other site 167555002328 H-loop/switch region; other site 167555002329 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 167555002330 Ferritin-like domain; Region: Ferritin; pfam00210 167555002331 ferroxidase diiron center [ion binding]; other site 167555002332 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 167555002333 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 167555002334 putative switch regulator; other site 167555002335 non-specific DNA interactions [nucleotide binding]; other site 167555002336 DNA binding site [nucleotide binding] 167555002337 sequence specific DNA binding site [nucleotide binding]; other site 167555002338 putative cAMP binding site [chemical binding]; other site 167555002339 chlorophyll a/b binding light-harvesting protein; Region: PS_antenn_a_b; TIGR03041 167555002340 AhpC/TSA antioxidant enzyme; Region: AhpC-TSA_2; pfam13911 167555002341 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 167555002342 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 167555002343 Walker A/P-loop; other site 167555002344 ATP binding site [chemical binding]; other site 167555002345 Q-loop/lid; other site 167555002346 ABC transporter signature motif; other site 167555002347 Walker B; other site 167555002348 D-loop; other site 167555002349 H-loop/switch region; other site 167555002350 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 167555002351 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 167555002352 [2Fe-2S] cluster binding site [ion binding]; other site 167555002353 UDP-glucose 4-epimerase; Region: PLN02240 167555002354 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 167555002355 NAD binding site [chemical binding]; other site 167555002356 homodimer interface [polypeptide binding]; other site 167555002357 active site 167555002358 substrate binding site [chemical binding]; other site 167555002359 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 167555002360 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 167555002361 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 167555002362 NADP binding site [chemical binding]; other site 167555002363 active site 167555002364 putative substrate binding site [chemical binding]; other site 167555002365 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 167555002366 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 167555002367 NAD binding site [chemical binding]; other site 167555002368 substrate binding site [chemical binding]; other site 167555002369 homodimer interface [polypeptide binding]; other site 167555002370 active site 167555002371 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 167555002372 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 167555002373 active site 167555002374 homodimer interface [polypeptide binding]; other site 167555002375 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 167555002376 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 167555002377 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 167555002378 NAD(P) binding site [chemical binding]; other site 167555002379 homodimer interface [polypeptide binding]; other site 167555002380 substrate binding site [chemical binding]; other site 167555002381 active site 167555002382 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 167555002383 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 167555002384 Mg++ binding site [ion binding]; other site 167555002385 putative catalytic motif [active] 167555002386 putative substrate binding site [chemical binding]; other site 167555002387 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 167555002388 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167555002389 NAD(P) binding site [chemical binding]; other site 167555002390 active site 167555002391 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 167555002392 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 167555002393 Heparinase II/III-like protein; Region: Hepar_II_III; cl15421 167555002394 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 167555002395 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 167555002396 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 167555002397 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 167555002398 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 167555002399 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 167555002400 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 167555002401 active site 167555002402 dimer interface [polypeptide binding]; other site 167555002403 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 167555002404 Ligand Binding Site [chemical binding]; other site 167555002405 Molecular Tunnel; other site 167555002406 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 167555002407 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 167555002408 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 167555002409 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 167555002410 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 167555002411 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 167555002412 Ligand Binding Site [chemical binding]; other site 167555002413 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 167555002414 NeuB family; Region: NeuB; pfam03102 167555002415 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 167555002416 NeuB binding interface [polypeptide binding]; other site 167555002417 putative substrate binding site [chemical binding]; other site 167555002418 UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568 167555002419 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 167555002420 active site 167555002421 homodimer interface [polypeptide binding]; other site 167555002422 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 167555002423 ligand binding site; other site 167555002424 tetramer interface; other site 167555002425 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 167555002426 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 167555002427 substrate binding site [chemical binding]; other site 167555002428 glutamase interaction surface [polypeptide binding]; other site 167555002429 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 167555002430 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 167555002431 putative active site [active] 167555002432 oxyanion strand; other site 167555002433 catalytic triad [active] 167555002434 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 167555002435 Chain length determinant protein; Region: Wzz; pfam02706 167555002436 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 167555002437 HicB family; Region: HicB; pfam05534 167555002438 Protein of unknown function (DUF3804); Region: DUF3804; pfam12707 167555002439 L-asparaginase II; Region: Asparaginase_II; pfam06089 167555002440 Protein of unknown function (DUF1230); Region: DUF1230; pfam06799 167555002441 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 167555002442 Protein of unknown function (DUF3318); Region: DUF3318; pfam11780 167555002443 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 167555002444 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 167555002445 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 167555002446 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 167555002447 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 167555002448 ATP-grasp domain; Region: ATP-grasp_4; cl17255 167555002449 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 167555002450 IMP binding site; other site 167555002451 dimer interface [polypeptide binding]; other site 167555002452 interdomain contacts; other site 167555002453 partial ornithine binding site; other site 167555002454 magnesium-protoporphyrin IX monomethyl ester cyclase; Provisional; Region: PRK13654 167555002455 dinuclear metal binding motif [ion binding]; other site 167555002456 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 167555002457 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 167555002458 catalytic loop [active] 167555002459 iron binding site [ion binding]; other site 167555002460 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 167555002461 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 167555002462 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 167555002463 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 167555002464 Walker A/P-loop; other site 167555002465 ATP binding site [chemical binding]; other site 167555002466 Q-loop/lid; other site 167555002467 ABC transporter signature motif; other site 167555002468 Walker B; other site 167555002469 D-loop; other site 167555002470 H-loop/switch region; other site 167555002471 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 167555002472 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 167555002473 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 167555002474 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 167555002475 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 167555002476 Protein of unknown function (DUF2862); Region: DUF2862; pfam11061 167555002477 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 167555002478 hypothetical protein; Provisional; Region: PRK10621 167555002479 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 167555002480 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 167555002481 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 167555002482 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 167555002483 active site 167555002484 homodimer interface [polypeptide binding]; other site 167555002485 catalytic site [active] 167555002486 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK00192 167555002487 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 167555002488 active site 167555002489 motif I; other site 167555002490 motif II; other site 167555002491 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 167555002492 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 167555002493 active site 167555002494 T5orf172 domain; Region: T5orf172; cl17462 167555002495 Bacitracin resistance protein BacA; Region: BacA; pfam02673 167555002496 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 167555002497 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 167555002498 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 167555002499 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 167555002500 Walker A/P-loop; other site 167555002501 ATP binding site [chemical binding]; other site 167555002502 Q-loop/lid; other site 167555002503 ABC transporter signature motif; other site 167555002504 Walker B; other site 167555002505 D-loop; other site 167555002506 H-loop/switch region; other site 167555002507 Protein of unknown function (DUF3288); Region: DUF3288; pfam11691 167555002508 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 167555002509 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 167555002510 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 167555002511 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 167555002512 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 167555002513 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 167555002514 catalytic site [active] 167555002515 subunit interface [polypeptide binding]; other site 167555002516 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 167555002517 anti sigma factor interaction site; other site 167555002518 regulatory phosphorylation site [posttranslational modification]; other site 167555002519 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cl00258 167555002520 active site 167555002521 metal binding site [ion binding]; metal-binding site 167555002522 dimerization interface [polypeptide binding]; other site 167555002523 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 167555002524 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 167555002525 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 167555002526 Domain of unknown function (DUF1816); Region: DUF1816; pfam08846 167555002527 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 167555002528 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 167555002529 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK07374 167555002530 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 167555002531 active site 167555002532 PHP Thumb interface [polypeptide binding]; other site 167555002533 metal binding site [ion binding]; metal-binding site 167555002534 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 167555002535 generic binding surface I; other site 167555002536 generic binding surface II; other site 167555002537 Protein of unknown function (DUF3464); Region: DUF3464; pfam11947 167555002538 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 167555002539 16S/18S rRNA binding site [nucleotide binding]; other site 167555002540 S13e-L30e interaction site [polypeptide binding]; other site 167555002541 25S rRNA binding site [nucleotide binding]; other site 167555002542 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 167555002543 RuvA N terminal domain; Region: RuvA_N; pfam01330 167555002544 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 167555002545 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 167555002546 EamA-like transporter family; Region: EamA; pfam00892 167555002547 EamA-like transporter family; Region: EamA; cl17759 167555002548 DNA primase; Validated; Region: dnaG; PRK05667 167555002549 CHC2 zinc finger; Region: zf-CHC2; cl17510 167555002550 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 167555002551 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 167555002552 active site 167555002553 metal binding site [ion binding]; metal-binding site 167555002554 interdomain interaction site; other site 167555002555 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 167555002556 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 167555002557 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 167555002558 active site 167555002559 DNA binding site [nucleotide binding] 167555002560 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 167555002561 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 167555002562 Catalytic site [active] 167555002563 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 167555002564 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 167555002565 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 167555002566 S-adenosylmethionine binding site [chemical binding]; other site 167555002567 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK02534 167555002568 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 167555002569 Protein of unknown function (DUF3082); Region: DUF3082; pfam11282 167555002570 pyruvate dehydrogenase E1 component beta subunit; Validated; Region: odpB; CHL00144 167555002571 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 167555002572 alpha subunit interface [polypeptide binding]; other site 167555002573 TPP binding site [chemical binding]; other site 167555002574 heterodimer interface [polypeptide binding]; other site 167555002575 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 167555002576 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 167555002577 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 167555002578 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 167555002579 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 167555002580 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 167555002581 Protein export membrane protein; Region: SecD_SecF; cl14618 167555002582 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 167555002583 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 167555002584 Predicted metal-binding protein (DUF2103); Region: DUF2103; pfam09876 167555002585 cytochrome b6-f complex subunit PetN; Provisional; Region: petN; PRK02529 167555002586 photosystem II biogenesis protein Psp29; Region: PS_II_psb29; TIGR03060 167555002587 Thf1-like protein; Reviewed; Region: PRK13266 167555002588 Clp protease; Region: CLP_protease; pfam00574 167555002589 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 167555002590 oligomer interface [polypeptide binding]; other site 167555002591 active site residues [active] 167555002592 cell division protein; Validated; Region: ftsH; CHL00176 167555002593 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167555002594 Walker A motif; other site 167555002595 ATP binding site [chemical binding]; other site 167555002596 Walker B motif; other site 167555002597 arginine finger; other site 167555002598 Peptidase family M41; Region: Peptidase_M41; pfam01434 167555002599 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 167555002600 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 167555002601 FtsX-like permease family; Region: FtsX; pfam02687 167555002602 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 167555002603 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 167555002604 domain interfaces; other site 167555002605 active site 167555002606 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 167555002607 putative metal binding site [ion binding]; other site 167555002608 YGGT family; Region: YGGT; pfam02325 167555002609 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 167555002610 threonine dehydratase; Reviewed; Region: PRK09224 167555002611 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 167555002612 tetramer interface [polypeptide binding]; other site 167555002613 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167555002614 catalytic residue [active] 167555002615 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 167555002616 putative Ile/Val binding site [chemical binding]; other site 167555002617 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 167555002618 putative Ile/Val binding site [chemical binding]; other site 167555002619 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 167555002620 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 167555002621 TPP-binding site; other site 167555002622 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 167555002623 PYR/PP interface [polypeptide binding]; other site 167555002624 dimer interface [polypeptide binding]; other site 167555002625 TPP binding site [chemical binding]; other site 167555002626 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 167555002627 photosystem I reaction center subunit PsaK; Region: PS_I_psaK; TIGR03049 167555002628 Protein of unknown function (DUF3593); Region: DUF3593; pfam12159 167555002629 Protein of unknown function (DUF2499); Region: DUF2499; pfam10693 167555002630 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 167555002631 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 167555002632 catalytic triad [active] 167555002633 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 167555002634 heat shock protein 90; Provisional; Region: PRK05218 167555002635 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 167555002636 ATP binding site [chemical binding]; other site 167555002637 Mg2+ binding site [ion binding]; other site 167555002638 G-X-G motif; other site 167555002639 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 167555002640 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 167555002641 dimer interface [polypeptide binding]; other site 167555002642 motif 1; other site 167555002643 active site 167555002644 motif 2; other site 167555002645 motif 3; other site 167555002646 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 167555002647 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 167555002648 active site 167555002649 dimerization interface [polypeptide binding]; other site 167555002650 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14259 167555002651 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 167555002652 Walker A/P-loop; other site 167555002653 ATP binding site [chemical binding]; other site 167555002654 Q-loop/lid; other site 167555002655 ABC transporter signature motif; other site 167555002656 Walker B; other site 167555002657 D-loop; other site 167555002658 H-loop/switch region; other site 167555002659 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 167555002660 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 167555002661 dimer interface [polypeptide binding]; other site 167555002662 conserved gate region; other site 167555002663 putative PBP binding loops; other site 167555002664 ABC-ATPase subunit interface; other site 167555002665 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 167555002666 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 167555002667 dimer interface [polypeptide binding]; other site 167555002668 conserved gate region; other site 167555002669 putative PBP binding loops; other site 167555002670 ABC-ATPase subunit interface; other site 167555002671 molecular chaperone DnaK; Provisional; Region: PRK13410 167555002672 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 167555002673 nucleotide binding site [chemical binding]; other site 167555002674 chaperone protein DnaJ; Provisional; Region: PRK14298 167555002675 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 167555002676 HSP70 interaction site [polypeptide binding]; other site 167555002677 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 167555002678 substrate binding site [polypeptide binding]; other site 167555002679 dimer interface [polypeptide binding]; other site 167555002680 Protein of unknown function (DUF3110); Region: DUF3110; pfam11360 167555002681 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 167555002682 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 167555002683 putative active site [active] 167555002684 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 167555002685 active site 167555002686 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II/unknown domain fusion protein; Provisional; Region: PRK09319 167555002687 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 167555002688 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 167555002689 dimerization interface [polypeptide binding]; other site 167555002690 active site 167555002691 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 167555002692 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 167555002693 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 167555002694 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 167555002695 active site 167555002696 substrate binding site [chemical binding]; other site 167555002697 cosubstrate binding site; other site 167555002698 catalytic site [active] 167555002699 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14096 167555002700 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 167555002701 active site 167555002702 dimer interface [polypeptide binding]; other site 167555002703 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 167555002704 dimer interface [polypeptide binding]; other site 167555002705 active site 167555002706 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 167555002707 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 167555002708 HIGH motif; other site 167555002709 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 167555002710 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 167555002711 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 167555002712 active site 167555002713 KMSKS motif; other site 167555002714 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 167555002715 tRNA binding surface [nucleotide binding]; other site 167555002716 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 167555002717 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 167555002718 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 167555002719 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 167555002720 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 167555002721 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 167555002722 catalytic residue [active] 167555002723 Domain of unknown function (DUF1995); Region: DUF1995; pfam09353 167555002724 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 167555002725 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 167555002726 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 167555002727 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 167555002728 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 167555002729 active site 167555002730 (T/H)XGH motif; other site 167555002731 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 167555002732 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 167555002733 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 167555002734 GIY-YIG motif/motif A; other site 167555002735 active site 167555002736 catalytic site [active] 167555002737 putative DNA binding site [nucleotide binding]; other site 167555002738 metal binding site [ion binding]; metal-binding site 167555002739 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cl00137 167555002740 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 167555002741 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 167555002742 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 167555002743 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 167555002744 active site 167555002745 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 167555002746 CobN/Magnesium Chelatase; Region: CobN-Mg_chel; pfam02514 167555002747 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 167555002748 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 167555002749 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 167555002750 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 167555002751 homodimer interface [polypeptide binding]; other site 167555002752 substrate-cofactor binding pocket; other site 167555002753 catalytic residue [active] 167555002754 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 167555002755 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 167555002756 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 167555002757 substrate binding pocket [chemical binding]; other site 167555002758 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 167555002759 B12 binding site [chemical binding]; other site 167555002760 cobalt ligand [ion binding]; other site 167555002761 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 167555002762 ATP adenylyltransferase (5',5'''-P-1,P-4-tetraphosphate phosphorylase II) [Nucleotide transport and metabolism]; Region: APA2; COG4360 167555002763 Src Homology 3 domain superfamily; Region: SH3; cl17036 167555002764 peptide ligand binding site [polypeptide binding]; other site 167555002765 ATP adenylyltransferase; Region: ATP_transf; pfam09830 167555002766 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 167555002767 HSP70 interaction site [polypeptide binding]; other site 167555002768 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 167555002769 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 167555002770 putative tRNA-binding site [nucleotide binding]; other site 167555002771 B3/4 domain; Region: B3_4; pfam03483 167555002772 tRNA synthetase B5 domain; Region: B5; smart00874 167555002773 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 167555002774 dimer interface [polypeptide binding]; other site 167555002775 motif 1; other site 167555002776 motif 3; other site 167555002777 motif 2; other site 167555002778 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 167555002779 ribosomal protein L33; Region: rpl33; CHL00104 167555002780 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 167555002781 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 167555002782 RNB domain; Region: RNB; pfam00773 167555002783 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 167555002784 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 167555002785 active site 167555002786 HIGH motif; other site 167555002787 KMSKS motif; other site 167555002788 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 167555002789 tRNA binding surface [nucleotide binding]; other site 167555002790 anticodon binding site; other site 167555002791 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 167555002792 Protein of unknown function (DUF2930); Region: DUF2930; pfam11152 167555002793 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 167555002794 homotrimer interface [polypeptide binding]; other site 167555002795 Walker A motif; other site 167555002796 GTP binding site [chemical binding]; other site 167555002797 Walker B motif; other site 167555002798 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 167555002799 PPOX class probable FMN-dependent enzyme, alr4036 family; Region: PPOX_FMN_cyano; TIGR04026 167555002800 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxase_2; pfam12766 167555002801 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 167555002802 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 167555002803 dimer interface [polypeptide binding]; other site 167555002804 decamer (pentamer of dimers) interface [polypeptide binding]; other site 167555002805 catalytic triad [active] 167555002806 peroxidatic and resolving cysteines [active] 167555002807 Protein of unknown function (DUF3529); Region: DUF3529; pfam12046 167555002808 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 167555002809 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167555002810 Walker A motif; other site 167555002811 ATP binding site [chemical binding]; other site 167555002812 Walker B motif; other site 167555002813 arginine finger; other site 167555002814 Peptidase family M41; Region: Peptidase_M41; pfam01434 167555002815 ribosomal protein L32; Validated; Region: rpl32; CHL00152 167555002816 Protein of unknown function (DUF565); Region: DUF565; pfam04483 167555002817 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 167555002818 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 167555002819 motif II; other site 167555002820 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 167555002821 DHH family; Region: DHH; pfam01368 167555002822 Predicted membrane protein [Function unknown]; Region: COG2119 167555002823 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 167555002824 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 167555002825 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 167555002826 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 167555002827 RNB domain; Region: RNB; pfam00773 167555002828 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 167555002829 RNA binding site [nucleotide binding]; other site 167555002830 aromatic acid decarboxylase; Validated; Region: PRK05920 167555002831 Flavoprotein; Region: Flavoprotein; pfam02441 167555002832 Protein of unknown function (DUF2996); Region: DUF2996; pfam11210 167555002833 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 167555002834 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 167555002835 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 167555002836 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 167555002837 putative active site [active] 167555002838 substrate binding site [chemical binding]; other site 167555002839 putative cosubstrate binding site; other site 167555002840 catalytic site [active] 167555002841 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 167555002842 substrate binding site [chemical binding]; other site 167555002843 Integral membrane protein TerC family; Region: TerC; cl10468 167555002844 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 167555002845 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 167555002846 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 167555002847 ATP binding site [chemical binding]; other site 167555002848 putative Mg++ binding site [ion binding]; other site 167555002849 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 167555002850 nucleotide binding region [chemical binding]; other site 167555002851 ATP-binding site [chemical binding]; other site 167555002852 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 167555002853 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 167555002854 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 167555002855 Domain of unknown function (DUF4335); Region: DUF4335; pfam14233 167555002856 Protein of unknown function (DUF3038); Region: DUF3038; pfam11237 167555002857 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 167555002858 Protein of unknown function (DUF2949); Region: DUF2949; pfam11165 167555002859 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 167555002860 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 167555002861 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 167555002862 dihydrodipicolinate reductase; Provisional; Region: PRK00048 167555002863 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 167555002864 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 167555002865 magnesium chelatase subunit H; Provisional; Region: PRK12493 167555002866 Domain of unknown function (DUF3479); Region: DUF3479; pfam11965 167555002867 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 167555002868 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 167555002869 dihydropteroate synthase; Region: DHPS; TIGR01496 167555002870 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 167555002871 substrate binding pocket [chemical binding]; other site 167555002872 dimer interface [polypeptide binding]; other site 167555002873 inhibitor binding site; inhibition site 167555002874 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 167555002875 triosephosphate isomerase; Provisional; Region: PRK14565 167555002876 substrate binding site [chemical binding]; other site 167555002877 dimer interface [polypeptide binding]; other site 167555002878 catalytic triad [active] 167555002879 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 167555002880 RNA binding surface [nucleotide binding]; other site 167555002881 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 167555002882 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 167555002883 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 167555002884 Walker A/P-loop; other site 167555002885 ATP binding site [chemical binding]; other site 167555002886 Q-loop/lid; other site 167555002887 ABC transporter signature motif; other site 167555002888 Walker B; other site 167555002889 D-loop; other site 167555002890 H-loop/switch region; other site 167555002891 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 167555002892 Protein of unknown function (DUF2862); Region: DUF2862; pfam11061 167555002893 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 167555002894 active site 167555002895 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 167555002896 NmrA-like family; Region: NmrA; pfam05368 167555002897 NADP binding site [chemical binding]; other site 167555002898 active site 167555002899 regulatory binding site [polypeptide binding]; other site 167555002900 Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862 167555002901 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 167555002902 Fatty acid desaturase; Region: FA_desaturase; pfam00487 167555002903 putative di-iron ligands [ion binding]; other site 167555002904 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 167555002905 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 167555002906 active site pocket [active] 167555002907 oxyanion hole [active] 167555002908 catalytic triad [active] 167555002909 active site nucleophile [active] 167555002910 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167555002911 NAD(P) binding site [chemical binding]; other site 167555002912 active site 167555002913 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 167555002914 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 167555002915 Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862 167555002916 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 167555002917 Ion channel; Region: Ion_trans_2; pfam07885 167555002918 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 167555002919 TrkA-N domain; Region: TrkA_N; pfam02254 167555002920 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 167555002921 This entry represents the putative helicase A859L; Region: T5orf172; smart00974 167555002922 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 167555002923 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 167555002924 Protein of unknown function, DUF393; Region: DUF393; pfam04134 167555002925 AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250 167555002926 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 167555002927 nucleotide binding pocket [chemical binding]; other site 167555002928 K-X-D-G motif; other site 167555002929 catalytic site [active] 167555002930 putative high light inducible protein; Region: PHA02337 167555002931 putative high light inducible protein; Region: PHA02337 167555002932 putative high light inducible protein; Region: PHA02337 167555002933 putative high light inducible protein; Region: PHA02337 167555002934 putative high light inducible protein; Region: PHA02337 167555002935 Protein of unknown function (DUF4090); Region: DUF4090; pfam13319 167555002936 Protein of unknown function (DUF938); Region: DUF938; pfam06080 167555002937 Transcription elongation factor Elf1 like; Region: Elf1; cl02038 167555002938 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 167555002939 Domain of unknown function DUF77; Region: DUF77; pfam01910 167555002940 Protein of unknown function (DUF3764); Region: DUF3764; pfam12594 167555002941 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 167555002942 dinuclear metal binding motif [ion binding]; other site 167555002943 putative high light inducible protein; Region: PHA02337 167555002944 putative high light inducible protein; Region: PHA02337 167555002945 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 167555002946 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 167555002947 ligand binding site [chemical binding]; other site 167555002948 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 167555002949 putative switch regulator; other site 167555002950 non-specific DNA interactions [nucleotide binding]; other site 167555002951 DNA binding site [nucleotide binding] 167555002952 sequence specific DNA binding site [nucleotide binding]; other site 167555002953 putative cAMP binding site [chemical binding]; other site 167555002954 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 167555002955 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 167555002956 active site 167555002957 phosphorylation site [posttranslational modification] 167555002958 intermolecular recognition site; other site 167555002959 dimerization interface [polypeptide binding]; other site 167555002960 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 167555002961 DNA binding site [nucleotide binding] 167555002962 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 167555002963 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 167555002964 dimer interface [polypeptide binding]; other site 167555002965 phosphorylation site [posttranslational modification] 167555002966 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 167555002967 ATP binding site [chemical binding]; other site 167555002968 Mg2+ binding site [ion binding]; other site 167555002969 G-X-G motif; other site 167555002970 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 167555002971 PBP superfamily domain; Region: PBP_like_2; cl17296 167555002972 Chromate transporter; Region: Chromate_transp; pfam02417 167555002973 Chromate transporter; Region: Chromate_transp; pfam02417 167555002974 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK08955 167555002975 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 167555002976 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 167555002977 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 167555002978 dimerization interface [polypeptide binding]; other site 167555002979 putative DNA binding site [nucleotide binding]; other site 167555002980 putative Zn2+ binding site [ion binding]; other site 167555002981 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 167555002982 Sodium Bile acid symporter family; Region: SBF; cl17470 167555002983 Protein of unknown function (DUF3804); Region: DUF3804; pfam12707 167555002984 Tryptophan-rich protein (DUF2389); Region: DUF2389; pfam09493 167555002985 Protein of unknown function (DUF1330); Region: DUF1330; pfam07045 167555002986 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 167555002987 MAPEG family; Region: MAPEG; pfam01124 167555002988 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 167555002989 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 167555002990 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 167555002991 Protein of unknown function (DUF3764); Region: DUF3764; pfam12594 167555002992 Predicted permeases [General function prediction only]; Region: COG0679 167555002993 Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286 167555002994 Rhomboid family; Region: Rhomboid; cl11446 167555002995 carotene isomerase; Region: carot_isom; TIGR02730 167555002996 Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547 167555002997 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 167555002998 Protein of unknown function (DUF3764); Region: DUF3764; pfam12594 167555002999 Protein of unknown function (DUF1499); Region: DUF1499; pfam07386 167555003000 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 167555003001 putative FMN binding site [chemical binding]; other site 167555003002 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 167555003003 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 167555003004 NAD binding site [chemical binding]; other site 167555003005 ATP-grasp domain; Region: ATP-grasp; pfam02222 167555003006 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 167555003007 Protein of unknown function (DUF3804); Region: DUF3804; pfam12707 167555003008 putative high light inducible protein; Region: PHA02337 167555003009 putative high light inducible protein; Region: PHA02337 167555003010 putative high light inducible protein; Region: PHA02337 167555003011 putative high light inducible protein; Region: PHA02337 167555003012 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 167555003013 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 167555003014 catalytic triad [active] 167555003015 Protein of unknown function (DUF1499); Region: DUF1499; pfam07386 167555003016 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 167555003017 TAP-like protein; Region: Abhydrolase_4; pfam08386 167555003018 haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549 167555003019 haloacid dehalogenase superfamily, subfamily IA hydrolase, TIGR01548; Region: HAD-SF-IA-hyp1 167555003020 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 167555003021 Protein of unknown function (DUF3764); Region: DUF3764; pfam12594 167555003022 Deoxyhypusine synthase; Region: DS; cl00826 167555003023 Uncharacterized conserved protein [Function unknown]; Region: COG0397 167555003024 hypothetical protein; Validated; Region: PRK00029 167555003025 Protein of unknown function (DUF3303); Region: DUF3303; pfam11746 167555003026 Photosystem I reaction centre subunit IX / PsaJ; Region: PSI_PsaJ; cl03320 167555003027 putative high light inducible protein; Region: PHA02337 167555003028 putative high light inducible protein; Region: PHA02337 167555003029 putative high light inducible protein; Region: PHA02337 167555003030 putative high light inducible protein; Region: PHA02337 167555003031 putative high light inducible protein; Region: PHA02337 167555003032 Protein of unknown function (DUF2839); Region: DUF2839; pfam10999 167555003033 hypothetical protein; Provisional; Region: PRK09256 167555003034 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 167555003035 protein I interface; other site 167555003036 D2 interface; other site 167555003037 protein T interface; other site 167555003038 chlorophyll binding site; other site 167555003039 beta carotene binding site; other site 167555003040 pheophytin binding site; other site 167555003041 manganese-stabilizing polypeptide interface; other site 167555003042 CP43 interface; other site 167555003043 protein L interface; other site 167555003044 oxygen evolving complex binding site; other site 167555003045 bromide binding site; other site 167555003046 quinone binding site; other site 167555003047 Fe binding site [ion binding]; other site 167555003048 core light harvesting interface; other site 167555003049 cytochrome b559 alpha subunit interface; other site 167555003050 cytochrome c-550 interface; other site 167555003051 protein J interface; other site 167555003052 endonuclease VIII; Provisional; Region: PRK10445 167555003053 N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965 167555003054 DNA binding site [nucleotide binding] 167555003055 catalytic residue [active] 167555003056 putative catalytic residues [active] 167555003057 H2TH interface [polypeptide binding]; other site 167555003058 intercalation triad [nucleotide binding]; other site 167555003059 substrate specificity determining residue; other site 167555003060 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 167555003061 PAP_fibrillin; Region: PAP_fibrillin; pfam04755 167555003062 Protein of unknown function (DUF3104); Region: DUF3104; pfam11302 167555003063 Protein of unknown function (DUF2839); Region: DUF2839; pfam10999 167555003064 2-oxoacid ferredoxin oxidoreductase; Provisional; Region: PRK13029 167555003065 Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862 167555003066 putative high light inducible protein; Region: PHA02337 167555003067 putative high light inducible protein; Region: PHA02337 167555003068 putative high light inducible protein; Region: PHA02337 167555003069 putative high light inducible protein; Region: PHA02337 167555003070 putative high light inducible protein; Region: PHA02337 167555003071 Protein of unknown function (DUF2811); Region: DUF2811; pfam10929 167555003072 Protein of unknown function (DUF2811); Region: DUF2811; pfam10929 167555003073 Protein of unknown function (DUF3764); Region: DUF3764; pfam12594 167555003074 Protein of unknown function (DUF3104); Region: DUF3104; pfam11302 167555003075 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 167555003076 trimer interface [polypeptide binding]; other site 167555003077 putative Zn binding site [ion binding]; other site 167555003078 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 167555003079 GSH binding site [chemical binding]; other site 167555003080 catalytic residues [active] 167555003081 Protein of unknown function (DUF3104); Region: DUF3104; pfam11302 167555003082 Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982 167555003083 Cupin domain; Region: Cupin_2; pfam07883 167555003084 ATP-dependent Clp protease adaptor; Reviewed; Region: clpS; PRK13019 167555003085 Cupin domain; Region: Cupin_2; pfam07883 167555003086 Protein of unknown function (DUF2997); Region: DUF2997; pfam11211 167555003087 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 167555003088 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 167555003089 catalytic loop [active] 167555003090 iron binding site [ion binding]; other site 167555003091 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 167555003092 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 167555003093 RNA binding surface [nucleotide binding]; other site 167555003094 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 167555003095 probable active site [active] 167555003096 putative high light inducible protein; Region: PHA02337 167555003097 putative high light inducible protein; Region: PHA02337 167555003098 putative high light inducible protein; Region: PHA02337 167555003099 putative high light inducible protein; Region: PHA02337 167555003100 Protein of unknown function (DUF3104); Region: DUF3104; pfam11302 167555003101 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 167555003102 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 167555003103 Walker A/P-loop; other site 167555003104 ATP binding site [chemical binding]; other site 167555003105 Q-loop/lid; other site 167555003106 ABC transporter signature motif; other site 167555003107 Walker B; other site 167555003108 D-loop; other site 167555003109 H-loop/switch region; other site 167555003110 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 167555003111 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 167555003112 dimer interface [polypeptide binding]; other site 167555003113 conserved gate region; other site 167555003114 putative PBP binding loops; other site 167555003115 ABC-ATPase subunit interface; other site 167555003116 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 167555003117 dimer interface [polypeptide binding]; other site 167555003118 conserved gate region; other site 167555003119 ABC-ATPase subunit interface; other site 167555003120 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 167555003121 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 167555003122 substrate binding pocket [chemical binding]; other site 167555003123 membrane-bound complex binding site; other site 167555003124 hinge residues; other site 167555003125 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 167555003126 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 167555003127 HupE / UreJ protein; Region: HupE_UreJ; cl01011 167555003128 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 167555003129 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 167555003130 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 167555003131 Sulfate transporter family; Region: Sulfate_transp; pfam00916 167555003132 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 167555003133 Protein of unknown function (DUF3303); Region: DUF3303; pfam11746 167555003134 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 167555003135 Glucose inhibited division protein A; Region: GIDA; pfam01134 167555003136 carotene isomerase; Region: carot_isom; TIGR02730 167555003137 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 167555003138 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 167555003139 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 167555003140 active site 167555003141 phosphorylation site [posttranslational modification] 167555003142 intermolecular recognition site; other site 167555003143 dimerization interface [polypeptide binding]; other site 167555003144 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 167555003145 DNA binding site [nucleotide binding] 167555003146 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 167555003147 putative GSH binding site [chemical binding]; other site 167555003148 catalytic residues [active] 167555003149 BolA-like protein; Region: BolA; pfam01722 167555003150 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 167555003151 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 167555003152 putative acyl-acceptor binding pocket; other site 167555003153 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 167555003154 active site 167555003155 hydrophilic channel; other site 167555003156 dimerization interface [polypeptide binding]; other site 167555003157 catalytic residues [active] 167555003158 active site lid [active] 167555003159 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 167555003160 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 167555003161 Phospholipid methyltransferase; Region: PEMT; cl17370 167555003162 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 167555003163 Part of AAA domain; Region: AAA_19; pfam13245 167555003164 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 167555003165 AAA domain; Region: AAA_30; pfam13604 167555003166 Family description; Region: UvrD_C_2; pfam13538 167555003167 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 167555003168 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 167555003169 ATP binding site [chemical binding]; other site 167555003170 Mg++ binding site [ion binding]; other site 167555003171 motif III; other site 167555003172 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 167555003173 nucleotide binding region [chemical binding]; other site 167555003174 ATP-binding site [chemical binding]; other site 167555003175 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 167555003176 putative RNA binding site [nucleotide binding]; other site 167555003177 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 167555003178 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 167555003179 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 167555003180 Walker A/P-loop; other site 167555003181 ATP binding site [chemical binding]; other site 167555003182 Q-loop/lid; other site 167555003183 ABC transporter signature motif; other site 167555003184 Walker B; other site 167555003185 D-loop; other site 167555003186 H-loop/switch region; other site 167555003187 PsbP; Region: PsbP; pfam01789 167555003188 recombination protein RecR; Reviewed; Region: recR; PRK00076 167555003189 RecR protein; Region: RecR; pfam02132 167555003190 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 167555003191 putative active site [active] 167555003192 putative metal-binding site [ion binding]; other site 167555003193 tetramer interface [polypeptide binding]; other site 167555003194 lipoyl synthase; Provisional; Region: PRK12928 167555003195 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 167555003196 FeS/SAM binding site; other site 167555003197 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 167555003198 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 167555003199 active site residue [active] 167555003200 biotin synthase; Region: bioB; TIGR00433 167555003201 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 167555003202 FeS/SAM binding site; other site 167555003203 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 167555003204 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 167555003205 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 167555003206 catalytic residue [active] 167555003207 putative FPP diphosphate binding site; other site 167555003208 putative FPP binding hydrophobic cleft; other site 167555003209 dimer interface [polypeptide binding]; other site 167555003210 putative IPP diphosphate binding site; other site 167555003211 Uncharacterized conserved protein [Function unknown]; Region: COG1624 167555003212 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 167555003213 diaminopimelate decarboxylase; Region: lysA; TIGR01048 167555003214 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 167555003215 active site 167555003216 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 167555003217 substrate binding site [chemical binding]; other site 167555003218 catalytic residues [active] 167555003219 dimer interface [polypeptide binding]; other site 167555003220 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 167555003221 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 167555003222 Coenzyme A binding pocket [chemical binding]; other site 167555003223 Clp protease ATP binding subunit; Region: clpC; CHL00095 167555003224 Clp amino terminal domain; Region: Clp_N; pfam02861 167555003225 Clp amino terminal domain; Region: Clp_N; pfam02861 167555003226 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167555003227 Walker A motif; other site 167555003228 ATP binding site [chemical binding]; other site 167555003229 Walker B motif; other site 167555003230 arginine finger; other site 167555003231 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167555003232 Walker A motif; other site 167555003233 ATP binding site [chemical binding]; other site 167555003234 Walker B motif; other site 167555003235 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 167555003236 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 167555003237 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 167555003238 putative active site [active] 167555003239 metal binding site [ion binding]; metal-binding site 167555003240 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 167555003241 PGAP1-like protein; Region: PGAP1; pfam07819 167555003242 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 167555003243 phosphatidate cytidylyltransferase; Region: PLN02953 167555003244 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 167555003245 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 167555003246 catalytic residue [active] 167555003247 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 167555003248 ABC1 family; Region: ABC1; cl17513 167555003249 Helix-turn-helix domain; Region: HTH_25; pfam13413 167555003250 4-alpha-glucanotransferase; Provisional; Region: PRK14508 167555003251 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02812 167555003252 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 167555003253 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 167555003254 active site 167555003255 aminopeptidase N; Provisional; Region: pepN; PRK14015 167555003256 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 167555003257 Zn binding site [ion binding]; other site 167555003258 adaptive-response sensory kinase; Validated; Region: PRK09303 167555003259 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 167555003260 tetramer interface [polypeptide binding]; other site 167555003261 dimer interface [polypeptide binding]; other site 167555003262 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 167555003263 dimer interface [polypeptide binding]; other site 167555003264 phosphorylation site [posttranslational modification] 167555003265 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 167555003266 ATP binding site [chemical binding]; other site 167555003267 Mg2+ binding site [ion binding]; other site 167555003268 G-X-G motif; other site 167555003269 ferredoxin--NADP+ reductase; Provisional; Region: PLN03116 167555003270 These ferredoxin reductases are related to the NADPH cytochrome p450 reductases (CYPOR), but lack the FAD-binding region connecting sub-domain. Ferredoxin-NADP+ reductase (FNR) is an FAD-containing enzyme that catalyzes the reversible electron transfer...; Region: CYPOR_like_FNR; cd06208 167555003271 dimerization interface [polypeptide binding]; other site 167555003272 FAD binding pocket [chemical binding]; other site 167555003273 FAD binding motif [chemical binding]; other site 167555003274 catalytic residues [active] 167555003275 NAD binding pocket [chemical binding]; other site 167555003276 phosphate binding motif [ion binding]; other site 167555003277 beta-alpha-beta structure motif; other site 167555003278 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 167555003279 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 167555003280 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 167555003281 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 167555003282 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 167555003283 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 167555003284 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 167555003285 catalytic triad [active] 167555003286 AAA domain; Region: AAA_30; pfam13604 167555003287 Family description; Region: UvrD_C_2; pfam13538 167555003288 Divergent PAP2 family; Region: DUF212; pfam02681 167555003289 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 167555003290 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 167555003291 substrate binding pocket [chemical binding]; other site 167555003292 chain length determination region; other site 167555003293 substrate-Mg2+ binding site; other site 167555003294 catalytic residues [active] 167555003295 aspartate-rich region 1; other site 167555003296 active site lid residues [active] 167555003297 aspartate-rich region 2; other site 167555003298 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14186 167555003299 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 167555003300 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 167555003301 homodimer interface [polypeptide binding]; other site 167555003302 NADP binding site [chemical binding]; other site 167555003303 substrate binding site [chemical binding]; other site 167555003304 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 167555003305 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 167555003306 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 167555003307 Zn2+ binding site [ion binding]; other site 167555003308 Mg2+ binding site [ion binding]; other site 167555003309 2-isopropylmalate synthase; Validated; Region: PRK00915 167555003310 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 167555003311 active site 167555003312 catalytic residues [active] 167555003313 metal binding site [ion binding]; metal-binding site 167555003314 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 167555003315 Uncharacterized conserved protein [Function unknown]; Region: COG1543 167555003316 N-terminal catalytic domain of alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792 167555003317 active site 167555003318 substrate binding site [chemical binding]; other site 167555003319 catalytic site [active] 167555003320 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 167555003321 lycopene cyclase family protein; Region: carotene-cycl; TIGR01790 167555003322 lycopene cyclase; Region: lycopene_cycl; TIGR01789 167555003323 DNA gyrase subunit A; Validated; Region: PRK05560 167555003324 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 167555003325 CAP-like domain; other site 167555003326 active site 167555003327 primary dimer interface [polypeptide binding]; other site 167555003328 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 167555003329 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 167555003330 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 167555003331 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 167555003332 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 167555003333 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 167555003334 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 167555003335 active site 167555003336 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 167555003337 catalytic residues [active] 167555003338 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 167555003339 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 167555003340 putative active site [active] 167555003341 oxyanion strand; other site 167555003342 catalytic triad [active] 167555003343 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 167555003344 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 167555003345 S-adenosylmethionine binding site [chemical binding]; other site 167555003346 Cytochrome B6-F complex subunit 5; Region: PetG; pfam02529 167555003347 Cytochrome c; Region: Cytochrom_C; pfam00034 167555003348 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 167555003349 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 167555003350 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 167555003351 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 167555003352 Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081 167555003353 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 167555003354 Walker A motif; other site 167555003355 ATP binding site [chemical binding]; other site 167555003356 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 167555003357 active site 167555003358 putative DNA-binding cleft [nucleotide binding]; other site 167555003359 dimer interface [polypeptide binding]; other site 167555003360 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 167555003361 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 167555003362 Fe-S metabolism associated domain; Region: SufE; cl00951 167555003363 homoserine dehydrogenase; Provisional; Region: PRK06349 167555003364 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 167555003365 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 167555003366 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 167555003367 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_20; cd08519 167555003368 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 167555003369 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 167555003370 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 167555003371 dimer interface [polypeptide binding]; other site 167555003372 conserved gate region; other site 167555003373 putative PBP binding loops; other site 167555003374 ABC-ATPase subunit interface; other site 167555003375 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 167555003376 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 167555003377 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 167555003378 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 167555003379 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 167555003380 substrate binding site [chemical binding]; other site 167555003381 ATP binding site [chemical binding]; other site 167555003382 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 167555003383 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 167555003384 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 167555003385 macrophage migration inhibition factor-like protein; Provisional; Region: PTZ00397 167555003386 Protein of unknown function, DUF393; Region: DUF393; pfam04134 167555003387 chlorophyll a/b binding light-harvesting protein; Region: PS_antenn_a_b; TIGR03041 167555003388 chlorophyll a/b binding light-harvesting protein; Region: PS_antenn_a_b; TIGR03041 167555003389 chlorophyll a/b binding light-harvesting protein; Region: PS_antenn_a_b; TIGR03041 167555003390 chlorophyll a/b binding light-harvesting protein; Region: PS_antenn_a_b; TIGR03041 167555003391 chlorophyll a/b binding light-harvesting protein; Region: PS_antenn_a_b; TIGR03041 167555003392 Protein of unknown function (DUF2805); Region: DUF2805; pfam10985 167555003393 Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013 167555003394 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 167555003395 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 167555003396 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 167555003397 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 167555003398 catalytic triad [active] 167555003399 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 167555003400 short chain dehydrogenase; Provisional; Region: PRK06197 167555003401 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 167555003402 putative NAD(P) binding site [chemical binding]; other site 167555003403 active site 167555003404 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 167555003405 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 167555003406 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 167555003407 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 167555003408 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 167555003409 Uncharacterized conserved protein [Function unknown]; Region: COG2308 167555003410 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 167555003411 protein I interface; other site 167555003412 D2 interface; other site 167555003413 protein T interface; other site 167555003414 chlorophyll binding site; other site 167555003415 beta carotene binding site; other site 167555003416 pheophytin binding site; other site 167555003417 manganese-stabilizing polypeptide interface; other site 167555003418 CP43 interface; other site 167555003419 protein L interface; other site 167555003420 oxygen evolving complex binding site; other site 167555003421 bromide binding site; other site 167555003422 quinone binding site; other site 167555003423 Fe binding site [ion binding]; other site 167555003424 core light harvesting interface; other site 167555003425 cytochrome b559 alpha subunit interface; other site 167555003426 cytochrome c-550 interface; other site 167555003427 protein J interface; other site 167555003428 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 167555003429 putative amphipathic alpha helix; other site 167555003430 TPR repeat; Region: TPR_11; pfam13414 167555003431 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 167555003432 binding surface 167555003433 Tetratricopeptide repeat; Region: TPR_12; pfam13424 167555003434 TPR motif; other site 167555003435 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 167555003436 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 167555003437 Domain of unknown function (DUF4214); Region: DUF4214; pfam13946 167555003438 Domain of unknown function (DUF4214); Region: DUF4214; pfam13946 167555003439 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 167555003440 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 167555003441 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 167555003442 metal binding site [ion binding]; metal-binding site 167555003443 Diadenosine tetraphosphatase and related serine/threonine protein phosphatases [Signal transduction mechanisms]; Region: ApaH; COG0639 167555003444 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 167555003445 GTP-binding protein YchF; Reviewed; Region: PRK09601 167555003446 YchF GTPase; Region: YchF; cd01900 167555003447 G1 box; other site 167555003448 GTP/Mg2+ binding site [chemical binding]; other site 167555003449 Switch I region; other site 167555003450 G2 box; other site 167555003451 Switch II region; other site 167555003452 G3 box; other site 167555003453 G4 box; other site 167555003454 G5 box; other site 167555003455 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 167555003456 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 167555003457 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 167555003458 HlyD family secretion protein; Region: HlyD_3; pfam13437 167555003459 DNA polymerase I; Provisional; Region: PRK05755 167555003460 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 167555003461 active site 167555003462 metal binding site 1 [ion binding]; metal-binding site 167555003463 putative 5' ssDNA interaction site; other site 167555003464 metal binding site 3; metal-binding site 167555003465 metal binding site 2 [ion binding]; metal-binding site 167555003466 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 167555003467 putative DNA binding site [nucleotide binding]; other site 167555003468 putative metal binding site [ion binding]; other site 167555003469 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 167555003470 active site 167555003471 catalytic site [active] 167555003472 substrate binding site [chemical binding]; other site 167555003473 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 167555003474 active site 167555003475 DNA binding site [nucleotide binding] 167555003476 catalytic site [active] 167555003477 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 167555003478 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 167555003479 active site 167555003480 HIGH motif; other site 167555003481 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 167555003482 KMSKS motif; other site 167555003483 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 167555003484 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 167555003485 Na2 binding site [ion binding]; other site 167555003486 putative substrate binding site 1 [chemical binding]; other site 167555003487 Na binding site 1 [ion binding]; other site 167555003488 putative substrate binding site 2 [chemical binding]; other site 167555003489 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 167555003490 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 167555003491 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 167555003492 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 167555003493 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 167555003494 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 167555003495 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 167555003496 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 167555003497 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 167555003498 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 167555003499 ligand binding site [chemical binding]; other site 167555003500 homodimer interface [polypeptide binding]; other site 167555003501 NAD(P) binding site [chemical binding]; other site 167555003502 trimer interface B [polypeptide binding]; other site 167555003503 trimer interface A [polypeptide binding]; other site 167555003504 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 167555003505 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 167555003506 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 167555003507 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 167555003508 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 167555003509 rRNA binding site [nucleotide binding]; other site 167555003510 predicted 30S ribosome binding site; other site 167555003511 Ycf39; Provisional; Region: ycf39; CHL00194 167555003512 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 167555003513 NAD(P) binding site [chemical binding]; other site 167555003514 putative active site [active] 167555003515 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 167555003516 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 167555003517 acetohydroxyacid synthase small subunit; Region: ilvH; CHL00100 167555003518 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 167555003519 putative valine binding site [chemical binding]; other site 167555003520 dimer interface [polypeptide binding]; other site 167555003521 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 167555003522 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD; Region: Pro_isomerase; pfam00160 167555003523 active site 167555003524 photosystem I assembly protein Ycf4; Provisional; Region: PRK02542 167555003525 photosystem II protein D2; Region: psbD; CHL00004 167555003526 pheophytin binding site; other site 167555003527 chlorophyll binding site; other site 167555003528 quinone binding site; other site 167555003529 Fe binding site [ion binding]; other site 167555003530 Photosystem II protein; Region: PSII; cl08223 167555003531 photosystem II 44 kDa subunit reaction center protein (also called P6 protein, CP43), bacterial and chloroplast; Region: psbC; TIGR01153 167555003532 Maf-like protein; Region: Maf; pfam02545 167555003533 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 167555003534 active site 167555003535 dimer interface [polypeptide binding]; other site 167555003536 cobyric acid synthase; Provisional; Region: PRK00784 167555003537 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 167555003538 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 167555003539 catalytic triad [active] 167555003540 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 167555003541 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 167555003542 catalytic loop [active] 167555003543 iron binding site [ion binding]; other site 167555003544 Interferon-induced transmembrane protein; Region: CD225; pfam04505 167555003545 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 167555003546 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 167555003547 S-adenosylmethionine binding site [chemical binding]; other site 167555003548 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 167555003549 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 167555003550 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 167555003551 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 167555003552 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 167555003553 dimer interface [polypeptide binding]; other site 167555003554 motif 1; other site 167555003555 active site 167555003556 motif 2; other site 167555003557 motif 3; other site 167555003558 Putative 2OG-Fe(II) oxygenase; Region: 2OG-FeII_Oxy_5; cl17879 167555003559 Putative 2OG-Fe(II) oxygenase; Region: 2OG-FeII_Oxy_5; cl17879 167555003560 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 167555003561 MAEBL; Provisional; Region: PTZ00121 167555003562 SnoaL-like domain; Region: SnoaL_2; pfam12680 167555003563 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 167555003564 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 167555003565 catalytic triad [active] 167555003566 Tetratricopeptide repeat; Region: TPR_16; pfam13432 167555003567 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 167555003568 binding surface 167555003569 TPR motif; other site 167555003570 TPR repeat; Region: TPR_11; pfam13414 167555003571 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 167555003572 TPR motif; other site 167555003573 binding surface 167555003574 TPR repeat; Region: TPR_11; pfam13414 167555003575 Methyltransferase domain; Region: Methyltransf_31; pfam13847 167555003576 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 167555003577 S-adenosylmethionine binding site [chemical binding]; other site 167555003578 Uncharacterized conserved protein [Function unknown]; Region: COG4095 167555003579 cytochrome b559 subunit beta; Provisional; Region: psbF; PRK02561 167555003580 flavodoxin FldA; Validated; Region: PRK09267 167555003581 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 167555003582 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 167555003583 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 167555003584 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 167555003585 putative ADP-binding pocket [chemical binding]; other site 167555003586 EamA-like transporter family; Region: EamA; pfam00892 167555003587 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 167555003588 EamA-like transporter family; Region: EamA; pfam00892 167555003589 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 167555003590 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 167555003591 tandem repeat interface [polypeptide binding]; other site 167555003592 oligomer interface [polypeptide binding]; other site 167555003593 active site residues [active] 167555003594 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 167555003595 homotrimer interaction site [polypeptide binding]; other site 167555003596 active site 167555003597 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 167555003598 Ribonuclease P; Region: Ribonuclease_P; pfam00825 167555003599 Bacterial PH domain; Region: DUF304; pfam03703 167555003600 putative inner membrane protein translocase component YidC; Provisional; Region: PRK02654 167555003601 60Kd inner membrane protein; Region: 60KD_IMP; pfam02096 167555003602 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 167555003603 Ycf46; Provisional; Region: ycf46; CHL00195 167555003604 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167555003605 ATP binding site [chemical binding]; other site 167555003606 Walker A motif; other site 167555003607 Walker B motif; other site 167555003608 arginine finger; other site 167555003609 seryl-tRNA synthetase; Provisional; Region: PRK05431 167555003610 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 167555003611 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 167555003612 dimer interface [polypeptide binding]; other site 167555003613 active site 167555003614 motif 1; other site 167555003615 motif 2; other site 167555003616 motif 3; other site 167555003617 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 167555003618 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 167555003619 active site 167555003620 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 167555003621 protein binding site [polypeptide binding]; other site 167555003622 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 167555003623 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 167555003624 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 167555003625 RNase E interface [polypeptide binding]; other site 167555003626 trimer interface [polypeptide binding]; other site 167555003627 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 167555003628 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 167555003629 RNase E interface [polypeptide binding]; other site 167555003630 trimer interface [polypeptide binding]; other site 167555003631 active site 167555003632 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 167555003633 putative nucleic acid binding region [nucleotide binding]; other site 167555003634 G-X-X-G motif; other site 167555003635 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 167555003636 RNA binding site [nucleotide binding]; other site 167555003637 domain interface; other site 167555003638 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 167555003639 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 167555003640 active site 167555003641 Predicted methyltransferases [General function prediction only]; Region: COG0313 167555003642 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 167555003643 putative SAM binding site [chemical binding]; other site 167555003644 putative homodimer interface [polypeptide binding]; other site 167555003645 acetylglucosaminyltransferase family protein; Provisional; Region: PLN03183 167555003646 Predicted membrane protein (DUF2214); Region: DUF2214; pfam09980 167555003647 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 167555003648 TPR repeat; Region: TPR_11; pfam13414 167555003649 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 167555003650 binding surface 167555003651 TPR motif; other site 167555003652 TPR repeat; Region: TPR_11; pfam13414 167555003653 Putative 2OG-Fe(II) oxygenase; Region: 2OG-FeII_Oxy_5; pfam13759 167555003654 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 167555003655 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 167555003656 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 167555003657 Catalytic site [active] 167555003658 ornithine carbamoyltransferase; Provisional; Region: PRK00779 167555003659 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 167555003660 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 167555003661 FtsH Extracellular; Region: FtsH_ext; pfam06480 167555003662 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 167555003663 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167555003664 Walker A motif; other site 167555003665 ATP binding site [chemical binding]; other site 167555003666 Walker B motif; other site 167555003667 arginine finger; other site 167555003668 Peptidase family M41; Region: Peptidase_M41; pfam01434 167555003669 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 167555003670 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 167555003671 catalytic motif [active] 167555003672 Zn binding site [ion binding]; other site 167555003673 RibD C-terminal domain; Region: RibD_C; cl17279 167555003674 Protein of unknown function (DUF3122); Region: DUF3122; pfam11320 167555003675 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 167555003676 active site 167555003677 putative homodimer interface [polypeptide binding]; other site 167555003678 SAM binding site [chemical binding]; other site 167555003679 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 167555003680 precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; Region: CbiT; TIGR02469 167555003681 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02649 167555003682 ATP-NAD kinase; Region: NAD_kinase; pfam01513 167555003683 phenylalanyl-tRNA synthetase, alpha subunit; Region: pheS; TIGR00468 167555003684 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 167555003685 dimer interface [polypeptide binding]; other site 167555003686 motif 1; other site 167555003687 active site 167555003688 motif 2; other site 167555003689 motif 3; other site 167555003690 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 167555003691 Protein of unknown function (DUF3611); Region: DUF3611; pfam12263 167555003692 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 167555003693 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 167555003694 active site 167555003695 Riboflavin kinase; Region: Flavokinase; smart00904 167555003696 thiamine-phosphate pyrophosphorylase; Provisional; Region: PRK02615 167555003697 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 167555003698 thiamine phosphate binding site [chemical binding]; other site 167555003699 active site 167555003700 pyrophosphate binding site [ion binding]; other site 167555003701 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 167555003702 thiS-thiF/thiG interaction site; other site 167555003703 Protein of unknown function (DUF1517); Region: DUF1517; cl01807 167555003704 Protein of unknown function (DUF1517); Region: DUF1517; pfam07466 167555003705 AIR carboxylase; Region: AIRC; smart01001 167555003706 uncharacterized cyanobacterial protein, TIGR03792 family; Region: TIGR03792 167555003707 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 167555003708 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 167555003709 homotrimer interaction site [polypeptide binding]; other site 167555003710 zinc binding site [ion binding]; other site 167555003711 CDP-binding sites; other site 167555003712 GTPase Era; Reviewed; Region: era; PRK00089 167555003713 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 167555003714 G1 box; other site 167555003715 GTP/Mg2+ binding site [chemical binding]; other site 167555003716 Switch I region; other site 167555003717 G2 box; other site 167555003718 Switch II region; other site 167555003719 G3 box; other site 167555003720 G4 box; other site 167555003721 G5 box; other site 167555003722 KH domain; Region: KH_2; pfam07650 167555003723 BAX inhibitor (BI)-1/YccA-like protein family; Region: BI-1-like; cl00473 167555003724 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 167555003725 PhoH-like protein; Region: PhoH; pfam02562 167555003726 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 167555003727 signal recognition particle protein; Provisional; Region: PRK10867 167555003728 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 167555003729 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 167555003730 Signal peptide binding domain; Region: SRP_SPB; pfam02978 167555003731 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 167555003732 Protein of unknown function (DUF4101); Region: DUF4101; pfam13355 167555003733 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 167555003734 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 167555003735 tetramer interface [polypeptide binding]; other site 167555003736 TPP-binding site [chemical binding]; other site 167555003737 heterodimer interface [polypeptide binding]; other site 167555003738 phosphorylation loop region [posttranslational modification] 167555003739 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 167555003740 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 167555003741 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 167555003742 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 167555003743 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 167555003744 DNA binding residues [nucleotide binding] 167555003745 Uncharacterized conserved protein [Function unknown]; Region: COG0062 167555003746 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 167555003747 putative substrate binding site [chemical binding]; other site 167555003748 putative ATP binding site [chemical binding]; other site 167555003749 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 167555003750 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 167555003751 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 167555003752 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 167555003753 putative active site [active] 167555003754 catalytic triad [active] 167555003755 putative dimer interface [polypeptide binding]; other site 167555003756 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 167555003757 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 167555003758 superoxide dismutase, Ni; Region: sodN; TIGR02753 167555003759 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 167555003760 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 167555003761 Catalytic site [active] 167555003762 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 167555003763 active site 167555003764 ribulose/triose binding site [chemical binding]; other site 167555003765 phosphate binding site [ion binding]; other site 167555003766 substrate (anthranilate) binding pocket [chemical binding]; other site 167555003767 product (indole) binding pocket [chemical binding]; other site 167555003768 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 167555003769 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 167555003770 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 167555003771 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 167555003772 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 167555003773 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 167555003774 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 167555003775 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 167555003776 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 167555003777 hinge; other site 167555003778 active site 167555003779 acetylornithine aminotransferase; Provisional; Region: PRK02627 167555003780 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 167555003781 inhibitor-cofactor binding pocket; inhibition site 167555003782 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167555003783 catalytic residue [active] 167555003784 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 167555003785 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 167555003786 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 167555003787 FAD binding domain; Region: FAD_binding_4; pfam01565 167555003788 cytosine deaminase-like protein; Validated; Region: PRK07583 167555003789 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 167555003790 active site 167555003791 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14333 167555003792 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 167555003793 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 167555003794 FeS/SAM binding site; other site 167555003795 TRAM domain; Region: TRAM; pfam01938 167555003796 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 167555003797 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 167555003798 ATP-grasp domain; Region: ATP-grasp_4; cl17255 167555003799 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 167555003800 cell division protein FtsZ; Validated; Region: PRK09330 167555003801 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 167555003802 nucleotide binding site [chemical binding]; other site 167555003803 SulA interaction site; other site 167555003804 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 167555003805 oligomerization interface [polypeptide binding]; other site 167555003806 active site 167555003807 metal binding site [ion binding]; metal-binding site 167555003808 coproporphyrinogen III oxidase; Provisional; Region: PRK07379 167555003809 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 167555003810 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 167555003811 putative active site [active] 167555003812 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 167555003813 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 167555003814 oligomer interface [polypeptide binding]; other site 167555003815 active site residues [active] 167555003816 Clp protease; Region: CLP_protease; pfam00574 167555003817 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 167555003818 oligomer interface [polypeptide binding]; other site 167555003819 active site residues [active] 167555003820 ketol-acid reductoisomerase; Provisional; Region: PRK05479 167555003821 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 167555003822 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 167555003823 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 167555003824 Bacterial sugar transferase; Region: Bac_transf; pfam02397 167555003825 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 167555003826 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 167555003827 putative ADP-binding pocket [chemical binding]; other site 167555003828 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07376 167555003829 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 167555003830 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 167555003831 IHF dimer interface [polypeptide binding]; other site 167555003832 IHF - DNA interface [nucleotide binding]; other site 167555003833 Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523 167555003834 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 167555003835 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 167555003836 active site 167555003837 catalytic site [active] 167555003838 MFS/sugar transport protein; Region: MFS_2; pfam13347 167555003839 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 167555003840 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 167555003841 Permease; Region: Permease; pfam02405 167555003842 Protein of unknown function (DUF3119); Region: DUF3119; pfam11317 167555003843 Protein of unknown function (DUF3086); Region: DUF3086; pfam11285 167555003844 membrane protein; Provisional; Region: PRK14419 167555003845 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 167555003846 active site 167555003847 dimer interface [polypeptide binding]; other site 167555003848 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 167555003849 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 167555003850 active site 167555003851 HIGH motif; other site 167555003852 dimer interface [polypeptide binding]; other site 167555003853 KMSKS motif; other site 167555003854 S4 domain; Region: S4; pfam01479 167555003855 RNA binding surface [nucleotide binding]; other site 167555003856 Domain of unknown function (DUF1825); Region: DUF1825; pfam08855 167555003857 multifunctional aminopeptidase A; Provisional; Region: PRK00913 167555003858 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 167555003859 interface (dimer of trimers) [polypeptide binding]; other site 167555003860 Substrate-binding/catalytic site; other site 167555003861 Zn-binding sites [ion binding]; other site 167555003862 Peptide methionine sulfoxide reductase; Region: PMSR; pfam01625 167555003863 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 167555003864 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 167555003865 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 167555003866 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 167555003867 active site 167555003868 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 167555003869 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 167555003870 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 167555003871 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 167555003872 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 167555003873 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 167555003874 Surface antigen; Region: Bac_surface_Ag; pfam01103 167555003875 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 167555003876 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 167555003877 ATP binding site [chemical binding]; other site 167555003878 active site 167555003879 substrate binding site [chemical binding]; other site 167555003880 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 167555003881 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 167555003882 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 167555003883 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 167555003884 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 167555003885 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 167555003886 dimerization interface [polypeptide binding]; other site 167555003887 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 167555003888 putative active site [active] 167555003889 heme pocket [chemical binding]; other site 167555003890 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 167555003891 dimer interface [polypeptide binding]; other site 167555003892 phosphorylation site [posttranslational modification] 167555003893 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 167555003894 ATP binding site [chemical binding]; other site 167555003895 Mg2+ binding site [ion binding]; other site 167555003896 G-X-G motif; other site 167555003897 circadian clock protein KaiC; Reviewed; Region: PRK09302 167555003898 KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124 167555003899 Walker A motif; other site 167555003900 ATP binding site [chemical binding]; other site 167555003901 Walker B motif; other site 167555003902 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 167555003903 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 167555003904 Walker A motif; other site 167555003905 Walker A motif; other site 167555003906 ATP binding site [chemical binding]; other site 167555003907 Walker B motif; other site 167555003908 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 167555003909 tetramer interface [polypeptide binding]; other site 167555003910 dimer interface [polypeptide binding]; other site 167555003911 ribosomal protein L21; Region: rpl21; CHL00075 167555003912 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 167555003913 Methyltransferase domain; Region: Methyltransf_23; pfam13489 167555003914 Methyltransferase domain; Region: Methyltransf_12; pfam08242 167555003915 S-adenosylmethionine binding site [chemical binding]; other site 167555003916 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02755 167555003917 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 167555003918 RNA binding site [nucleotide binding]; other site 167555003919 active site 167555003920 Stage II sporulation protein; Region: SpoIID; pfam08486 167555003921 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 167555003922 ribonuclease Z; Region: RNase_Z; TIGR02651 167555003923 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 167555003924 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 167555003925 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 167555003926 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 167555003927 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 167555003928 catalytic loop [active] 167555003929 iron binding site [ion binding]; other site 167555003930 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 167555003931 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 167555003932 S-adenosylmethionine binding site [chemical binding]; other site 167555003933 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 167555003934 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 167555003935 ligand binding site [chemical binding]; other site 167555003936 NAD binding site [chemical binding]; other site 167555003937 dimerization interface [polypeptide binding]; other site 167555003938 catalytic site [active] 167555003939 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 167555003940 putative L-serine binding site [chemical binding]; other site 167555003941 photosystem II S4 domain protein; Region: PS_II_S4; TIGR03069 167555003942 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 167555003943 RNA binding surface [nucleotide binding]; other site 167555003944 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02705 167555003945 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 167555003946 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 167555003947 GAF domain; Region: GAF; pfam01590 167555003948 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 167555003949 DoxX; Region: DoxX; pfam07681 167555003950 OsmC-like protein; Region: OsmC; pfam02566 167555003951 putative high light inducible protein; Region: PHA02337 167555003952 putative high light inducible protein; Region: PHA02337 167555003953 putative high light inducible protein; Region: PHA02337 167555003954 Protein of unknown function (DUF3386); Region: DUF3386; pfam11866 167555003955 putative high light inducible protein; Region: PHA02337 167555003956 putative high light inducible protein; Region: PHA02337 167555003957 Protein of unknown function (DUF3007); Region: DUF3007; pfam11460 167555003958 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 167555003959 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 167555003960 Walker A/P-loop; other site 167555003961 ATP binding site [chemical binding]; other site 167555003962 ABC transporter signature motif; other site 167555003963 Walker B; other site 167555003964 D-loop; other site 167555003965 H-loop/switch region; other site 167555003966 ABC transporter; Region: ABC_tran_2; pfam12848 167555003967 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 167555003968 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 167555003969 Protein of unknown function (DUF805); Region: DUF805; cl01224 167555003970 TPR repeat; Region: TPR_11; pfam13414 167555003971 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 167555003972 binding surface 167555003973 TPR repeat; Region: TPR_11; pfam13414 167555003974 TPR motif; other site 167555003975 TPR repeat; Region: TPR_11; pfam13414 167555003976 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 167555003977 binding surface 167555003978 TPR motif; other site 167555003979 Tetratricopeptide repeat; Region: TPR_12; pfam13424 167555003980 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 167555003981 Methyltransferase FkbM domain; Region: Methyltransf_21; pfam05050 167555003982 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 167555003983 binding surface 167555003984 TPR motif; other site 167555003985 TPR repeat; Region: TPR_11; pfam13414 167555003986 TPR repeat; Region: TPR_11; pfam13414 167555003987 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 167555003988 binding surface 167555003989 TPR motif; other site 167555003990 TPR repeat; Region: TPR_11; pfam13414 167555003991 TPR repeat; Region: TPR_11; pfam13414 167555003992 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 167555003993 binding surface 167555003994 TPR motif; other site 167555003995 TPR repeat; Region: TPR_11; pfam13414 167555003996 Tetratricopeptide repeat; Region: TPR_16; pfam13432 167555003997 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 167555003998 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 167555003999 Protein of unknown function (DUF4254); Region: DUF4254; pfam14063 167555004000 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 167555004001 DNA binding site [nucleotide binding] 167555004002 active site 167555004003 Int/Topo IB signature motif; other site 167555004004 Putative 2OG-Fe(II) oxygenase; Region: 2OG-FeII_Oxy_5; pfam13759 167555004005 Protein of unknown function (DUF1651); Region: DUF1651; pfam07864 167555004006 EVE domain; Region: EVE; cl00728 167555004007 Protein of unknown function (DUF2811); Region: DUF2811; pfam10929 167555004008 Domain of unknown function (DUF1818); Region: DUF1818; pfam08848 167555004009 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 167555004010 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 167555004011 nucleotide binding site [chemical binding]; other site 167555004012 putative NEF/HSP70 interaction site [polypeptide binding]; other site 167555004013 SBD interface [polypeptide binding]; other site 167555004014 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 167555004015 phosphoglyceromutase; Provisional; Region: PRK05434 167555004016 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 167555004017 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 167555004018 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 167555004019 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 167555004020 ring oligomerisation interface [polypeptide binding]; other site 167555004021 ATP/Mg binding site [chemical binding]; other site 167555004022 stacking interactions; other site 167555004023 hinge regions; other site 167555004024 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 167555004025 oligomerisation interface [polypeptide binding]; other site 167555004026 mobile loop; other site 167555004027 roof hairpin; other site 167555004028 ATP synthase CF1 beta subunit; Region: atpB; CHL00060 167555004029 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 167555004030 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 167555004031 alpha subunit interaction interface [polypeptide binding]; other site 167555004032 Walker A motif; other site 167555004033 ATP binding site [chemical binding]; other site 167555004034 Walker B motif; other site 167555004035 inhibitor binding site; inhibition site 167555004036 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 167555004037 ATP synthase CF1 epsilon subunit; Region: atpE; CHL00063 167555004038 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 167555004039 gamma subunit interface [polypeptide binding]; other site 167555004040 epsilon subunit interface [polypeptide binding]; other site 167555004041 LBP interface [polypeptide binding]; other site 167555004042 hypothetical protein; Provisional; Region: PRK02724 167555004043 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 167555004044 proline aminopeptidase P II; Provisional; Region: PRK10879 167555004045 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 167555004046 active site 167555004047 Domain of unknown function DUF21; Region: DUF21; pfam01595 167555004048 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 167555004049 Dynamin family; Region: Dynamin_N; pfam00350 167555004050 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 167555004051 G1 box; other site 167555004052 GTP/Mg2+ binding site [chemical binding]; other site 167555004053 Switch I region; other site 167555004054 G2 box; other site 167555004055 Switch II region; other site 167555004056 G3 box; other site 167555004057 G4 box; other site 167555004058 G5 box; other site 167555004059 Domain of unknown function (DUF697); Region: DUF697; pfam05128 167555004060 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 167555004061 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 167555004062 active site 167555004063 (T/H)XGH motif; other site 167555004064 NAD synthetase; Provisional; Region: PRK13981 167555004065 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 167555004066 multimer interface [polypeptide binding]; other site 167555004067 active site 167555004068 catalytic triad [active] 167555004069 protein interface 1 [polypeptide binding]; other site 167555004070 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 167555004071 homodimer interface [polypeptide binding]; other site 167555004072 NAD binding pocket [chemical binding]; other site 167555004073 ATP binding pocket [chemical binding]; other site 167555004074 Mg binding site [ion binding]; other site 167555004075 active-site loop [active] 167555004076 Protein of unknown function (DUF3326); Region: DUF3326; pfam11805 167555004077 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 167555004078 core domain interface [polypeptide binding]; other site 167555004079 delta subunit interface [polypeptide binding]; other site 167555004080 epsilon subunit interface [polypeptide binding]; other site 167555004081 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 167555004082 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 167555004083 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 167555004084 beta subunit interaction interface [polypeptide binding]; other site 167555004085 Walker A motif; other site 167555004086 ATP binding site [chemical binding]; other site 167555004087 Walker B motif; other site 167555004088 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 167555004089 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 167555004090 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13429 167555004091 F0F1 ATP synthase subunit B; Validated; Region: PRK07352 167555004092 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 167555004093 F0F1 ATP synthase subunit B'; Validated; Region: PRK07353 167555004094 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 167555004095 ATP synthase CF0 C subunit; Region: atpH; CHL00061 167555004096 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 167555004097 ATP synthase CF0 A subunit; Region: atpI; CHL00046 167555004098 Bacterial ATP synthase I; Region: Bac_ATP_syn_I; pfam05468 167555004099 Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098 167555004100 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 167555004101 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 167555004102 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 167555004103 ResB-like family; Region: ResB; pfam05140 167555004104 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 167555004105 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 167555004106 Nitrogen regulatory protein P-II; Region: P-II; smart00938 167555004107 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 167555004108 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 167555004109 RNA binding surface [nucleotide binding]; other site 167555004110 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 167555004111 adenylosuccinate lyase; Provisional; Region: PRK07380 167555004112 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 167555004113 tetramer interface [polypeptide binding]; other site 167555004114 active site 167555004115 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 167555004116 fumarate hydratase; Reviewed; Region: fumC; PRK00485 167555004117 Class II fumarases; Region: Fumarase_classII; cd01362 167555004118 active site 167555004119 tetramer interface [polypeptide binding]; other site 167555004120 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 167555004121 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 167555004122 ATP binding site [chemical binding]; other site 167555004123 putative Mg++ binding site [ion binding]; other site 167555004124 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 167555004125 nucleotide binding region [chemical binding]; other site 167555004126 ATP-binding site [chemical binding]; other site 167555004127 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 167555004128 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 167555004129 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 167555004130 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 167555004131 catalytic residue [active] 167555004132 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 167555004133 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 167555004134 S-adenosylmethionine binding site [chemical binding]; other site 167555004135 AAA domain; Region: AAA_26; pfam13500 167555004136 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 167555004137 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 167555004138 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 167555004139 inhibitor-cofactor binding pocket; inhibition site 167555004140 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167555004141 catalytic residue [active] 167555004142 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 167555004143 HSP70 interaction site [polypeptide binding]; other site 167555004144 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 167555004145 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 167555004146 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 167555004147 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 167555004148 active site 167555004149 catalytic tetrad [active] 167555004150 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 167555004151 Protein of unknown function (DUF1257); Region: DUF1257; pfam06868 167555004152 Protein of unknown function (DUF2997); Region: DUF2997; pfam11211 167555004153 HEAT repeats; Region: HEAT_2; pfam13646 167555004154 HEAT repeats; Region: HEAT_2; pfam13646 167555004155 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477 167555004156 Na binding site [ion binding]; other site 167555004157 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14457 167555004158 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 167555004159 FeS/SAM binding site; other site 167555004160 DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597 167555004161 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 167555004162 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 167555004163 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 167555004164 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 167555004165 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 167555004166 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 167555004167 DNA binding site [nucleotide binding] 167555004168 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 167555004169 DNA-directed RNA polymerase subunit gamma; Provisional; Region: rpoC1; PRK02625 167555004170 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 167555004171 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 167555004172 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 167555004173 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 167555004174 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 167555004175 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 167555004176 RPB1 interaction site [polypeptide binding]; other site 167555004177 RPB10 interaction site [polypeptide binding]; other site 167555004178 RPB11 interaction site [polypeptide binding]; other site 167555004179 RPB3 interaction site [polypeptide binding]; other site 167555004180 RPB12 interaction site [polypeptide binding]; other site 167555004181 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 167555004182 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 167555004183 active site 167555004184 ribosomal protein S20; Region: rps20; CHL00102 167555004185 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 167555004186 histidinol dehydrogenase; Region: hisD; TIGR00069 167555004187 NAD binding site [chemical binding]; other site 167555004188 dimerization interface [polypeptide binding]; other site 167555004189 product binding site; other site 167555004190 substrate binding site [chemical binding]; other site 167555004191 zinc binding site [ion binding]; other site 167555004192 catalytic residues [active] 167555004193 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 167555004194 tetramer (dimer of dimers) interface [polypeptide binding]; other site 167555004195 active site 167555004196 dimer interface [polypeptide binding]; other site 167555004197 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 167555004198 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 167555004199 protein binding site [polypeptide binding]; other site 167555004200 Sm and related proteins; Region: Sm_like; cl00259 167555004201 ribosome maturation protein RimP; Reviewed; Region: PRK00092 167555004202 heptamer interface [polypeptide binding]; other site 167555004203 Sm1 motif; other site 167555004204 hexamer interface [polypeptide binding]; other site 167555004205 RNA binding site [nucleotide binding]; other site 167555004206 Sm2 motif; other site 167555004207 transcription elongation factor NusA; Provisional; Region: nusA; PRK12329 167555004208 NusA N-terminal domain; Region: NusA_N; pfam08529 167555004209 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 167555004210 RNA binding site [nucleotide binding]; other site 167555004211 homodimer interface [polypeptide binding]; other site 167555004212 NusA-like KH domain; Region: KH_5; pfam13184 167555004213 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 167555004214 G-X-X-G motif; other site 167555004215 Protein of unknown function (DUF448); Region: DUF448; pfam04296 167555004216 putative RNA binding cleft [nucleotide binding]; other site 167555004217 translation initiation factor IF-2; Validated; Region: infB; PRK05306 167555004218 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 167555004219 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 167555004220 G1 box; other site 167555004221 putative GEF interaction site [polypeptide binding]; other site 167555004222 GTP/Mg2+ binding site [chemical binding]; other site 167555004223 Switch I region; other site 167555004224 G2 box; other site 167555004225 G3 box; other site 167555004226 Switch II region; other site 167555004227 G4 box; other site 167555004228 G5 box; other site 167555004229 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 167555004230 Translation-initiation factor 2; Region: IF-2; pfam11987 167555004231 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 167555004232 Protein of unknown function (DUF3493); Region: DUF3493; pfam11998 167555004233 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 167555004234 GTP cyclohydrolase I; Provisional; Region: PLN03044 167555004235 active site 167555004236 Protein of unknown function; Region: DUF3721; pfam12518 167555004237 GLTT repeat (6 copies); Region: GLTT; pfam01744 167555004238 GLTT repeat (6 copies); Region: GLTT; pfam01744 167555004239 Protein of unknown function; Region: DUF3721; pfam12518 167555004240 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 167555004241 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 167555004242 ABC-ATPase subunit interface; other site 167555004243 dimer interface [polypeptide binding]; other site 167555004244 putative PBP binding regions; other site 167555004245 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 167555004246 metal binding site 2 [ion binding]; metal-binding site 167555004247 putative DNA binding helix; other site 167555004248 metal binding site 1 [ion binding]; metal-binding site 167555004249 dimer interface [polypeptide binding]; other site 167555004250 structural Zn2+ binding site [ion binding]; other site 167555004251 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 167555004252 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 167555004253 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 167555004254 intersubunit interface [polypeptide binding]; other site 167555004255 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 167555004256 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 167555004257 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 167555004258 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 167555004259 P-loop, Walker A motif; other site 167555004260 Base recognition motif; other site 167555004261 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 167555004262 FOG: WD40 repeat [General function prediction only]; Region: COG2319 167555004263 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 167555004264 structural tetrad; other site 167555004265 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304 167555004266 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 167555004267 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 167555004268 Walker A/P-loop; other site 167555004269 ATP binding site [chemical binding]; other site 167555004270 Q-loop/lid; other site 167555004271 ABC transporter signature motif; other site 167555004272 Walker B; other site 167555004273 D-loop; other site 167555004274 H-loop/switch region; other site 167555004275 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 167555004276 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 167555004277 Walker A/P-loop; other site 167555004278 ATP binding site [chemical binding]; other site 167555004279 Q-loop/lid; other site 167555004280 ABC transporter signature motif; other site 167555004281 Walker B; other site 167555004282 D-loop; other site 167555004283 H-loop/switch region; other site 167555004284 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 167555004285 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 167555004286 TM-ABC transporter signature motif; other site 167555004287 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 167555004288 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 167555004289 TM-ABC transporter signature motif; other site 167555004290 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 167555004291 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 167555004292 putative ligand binding site [chemical binding]; other site 167555004293 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 167555004294 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 167555004295 UreF; Region: UreF; pfam01730 167555004296 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 167555004297 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 167555004298 dimer interface [polypeptide binding]; other site 167555004299 catalytic residues [active] 167555004300 UreD urease accessory protein; Region: UreD; pfam01774 167555004301 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 167555004302 alpha-gamma subunit interface [polypeptide binding]; other site 167555004303 beta-gamma subunit interface [polypeptide binding]; other site 167555004304 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 167555004305 gamma-beta subunit interface [polypeptide binding]; other site 167555004306 alpha-beta subunit interface [polypeptide binding]; other site 167555004307 urease subunit alpha; Reviewed; Region: ureC; PRK13207 167555004308 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 167555004309 subunit interactions [polypeptide binding]; other site 167555004310 active site 167555004311 flap region; other site 167555004312 Domain of unknown function (DUF1830); Region: DUF1830; pfam08865 167555004313 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 167555004314 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 167555004315 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 167555004316 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 167555004317 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 167555004318 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 167555004319 Radical SAM superfamily; Region: Radical_SAM; pfam04055 167555004320 FeS/SAM binding site; other site 167555004321 CAAX protease self-immunity; Region: Abi; pfam02517 167555004322 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 167555004323 L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590 167555004324 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 167555004325 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167555004326 homodimer interface [polypeptide binding]; other site 167555004327 catalytic residue [active] 167555004328 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 167555004329 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 167555004330 homodimer interface [polypeptide binding]; other site 167555004331 oligonucleotide binding site [chemical binding]; other site 167555004332 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 167555004333 RNA/DNA hybrid binding site [nucleotide binding]; other site 167555004334 active site 167555004335 Protein of unknown function (DUF1997); Region: DUF1997; pfam09366 167555004336 prephenate dehydratase; Provisional; Region: PRK11898 167555004337 Prephenate dehydratase; Region: PDT; pfam00800 167555004338 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 167555004339 putative L-Phe binding site [chemical binding]; other site 167555004340 tocopherol O-methyltransferase; Region: PLN02244 167555004341 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 167555004342 S-adenosylmethionine binding site [chemical binding]; other site 167555004343 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 167555004344 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 167555004345 elongation factor Tu; Reviewed; Region: PRK00049 167555004346 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 167555004347 G1 box; other site 167555004348 GEF interaction site [polypeptide binding]; other site 167555004349 GTP/Mg2+ binding site [chemical binding]; other site 167555004350 Switch I region; other site 167555004351 G2 box; other site 167555004352 G3 box; other site 167555004353 Switch II region; other site 167555004354 G4 box; other site 167555004355 G5 box; other site 167555004356 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 167555004357 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 167555004358 Antibiotic Binding Site [chemical binding]; other site 167555004359 elongation factor G; Reviewed; Region: PRK00007 167555004360 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 167555004361 G1 box; other site 167555004362 putative GEF interaction site [polypeptide binding]; other site 167555004363 GTP/Mg2+ binding site [chemical binding]; other site 167555004364 Switch I region; other site 167555004365 G2 box; other site 167555004366 G3 box; other site 167555004367 Switch II region; other site 167555004368 G4 box; other site 167555004369 G5 box; other site 167555004370 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 167555004371 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 167555004372 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 167555004373 30S ribosomal protein S7; Validated; Region: PRK05302 167555004374 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 167555004375 S17 interaction site [polypeptide binding]; other site 167555004376 S8 interaction site; other site 167555004377 16S rRNA interaction site [nucleotide binding]; other site 167555004378 streptomycin interaction site [chemical binding]; other site 167555004379 23S rRNA interaction site [nucleotide binding]; other site 167555004380 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 167555004381 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 167555004382 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 167555004383 active site 167555004384 dimer interface [polypeptide binding]; other site 167555004385 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 167555004386 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 167555004387 active site 167555004388 FMN binding site [chemical binding]; other site 167555004389 substrate binding site [chemical binding]; other site 167555004390 3Fe-4S cluster binding site [ion binding]; other site 167555004391 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 167555004392 domain interface; other site 167555004393 lipoyl synthase; Provisional; Region: PRK05481 167555004394 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 167555004395 FeS/SAM binding site; other site 167555004396 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 167555004397 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 167555004398 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 167555004399 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 167555004400 active site 167555004401 SAM binding site [chemical binding]; other site 167555004402 homodimer interface [polypeptide binding]; other site 167555004403 photosystem I P700 chlorophyll a apoprotein A1; Provisional; Region: psaA; PRK13200 167555004404 photosystem I P700 chlorophyll a apoprotein A2; Provisional; Region: psaB; PRK13199 167555004405 photosystem I reaction center protein subunit XI; Provisional; Region: PRK00704 167555004406 photosystem I reaction center subunit VIII; Reviewed; Region: psaI; PRK11877 167555004407 HEAT repeats; Region: HEAT_2; pfam13646 167555004408 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 167555004409 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 167555004410 Ligand binding site; other site 167555004411 Putative Catalytic site; other site 167555004412 DXD motif; other site 167555004413 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 167555004414 NlpC/P60 family; Region: NLPC_P60; pfam00877 167555004415 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 167555004416 Tetratricopeptide repeat; Region: TPR_16; pfam13432 167555004417 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 167555004418 binding surface 167555004419 TPR motif; other site 167555004420 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 167555004421 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 167555004422 binding surface 167555004423 TPR motif; other site 167555004424 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 167555004425 binding surface 167555004426 TPR motif; other site 167555004427 Methyltransferase domain; Region: Methyltransf_31; pfam13847 167555004428 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 167555004429 S-adenosylmethionine binding site [chemical binding]; other site 167555004430 alanine racemase; Reviewed; Region: alr; PRK00053 167555004431 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 167555004432 active site 167555004433 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 167555004434 dimer interface [polypeptide binding]; other site 167555004435 substrate binding site [chemical binding]; other site 167555004436 catalytic residues [active] 167555004437 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 167555004438 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 167555004439 active site 167555004440 peptide chain release factor 1; Validated; Region: prfA; PRK00591 167555004441 This domain is found in peptide chain release factors; Region: PCRF; smart00937 167555004442 RF-1 domain; Region: RF-1; pfam00472 167555004443 ribosomal protein L31; Validated; Region: rpl31; CHL00136 167555004444 ribosomal protein S9; Region: rps9; CHL00079 167555004445 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 167555004446 23S rRNA interface [nucleotide binding]; other site 167555004447 L3 interface [polypeptide binding]; other site 167555004448 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 167555004449 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 167555004450 dimerization interface 3.5A [polypeptide binding]; other site 167555004451 active site 167555004452 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 167555004453 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 167555004454 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 167555004455 alphaNTD homodimer interface [polypeptide binding]; other site 167555004456 alphaNTD - beta interaction site [polypeptide binding]; other site 167555004457 alphaNTD - beta' interaction site [polypeptide binding]; other site 167555004458 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 167555004459 30S ribosomal protein S11; Validated; Region: PRK05309 167555004460 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 167555004461 30S ribosomal protein S13; Region: bact_S13; TIGR03631 167555004462 adenylate kinase; Provisional; Region: PRK14531 167555004463 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 167555004464 AMP-binding site [chemical binding]; other site 167555004465 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 167555004466 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 167555004467 SecY translocase; Region: SecY; pfam00344 167555004468 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 167555004469 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 167555004470 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 167555004471 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 167555004472 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 167555004473 5S rRNA interface [nucleotide binding]; other site 167555004474 L27 interface [polypeptide binding]; other site 167555004475 23S rRNA interface [nucleotide binding]; other site 167555004476 L5 interface [polypeptide binding]; other site 167555004477 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 167555004478 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 167555004479 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 167555004480 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 167555004481 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 167555004482 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 167555004483 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 167555004484 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 167555004485 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 167555004486 RNA binding site [nucleotide binding]; other site 167555004487 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 167555004488 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 167555004489 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 167555004490 23S rRNA interface [nucleotide binding]; other site 167555004491 putative translocon interaction site; other site 167555004492 signal recognition particle (SRP54) interaction site; other site 167555004493 L23 interface [polypeptide binding]; other site 167555004494 trigger factor interaction site; other site 167555004495 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 167555004496 23S rRNA interface [nucleotide binding]; other site 167555004497 5S rRNA interface [nucleotide binding]; other site 167555004498 putative antibiotic binding site [chemical binding]; other site 167555004499 L25 interface [polypeptide binding]; other site 167555004500 L27 interface [polypeptide binding]; other site 167555004501 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 167555004502 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 167555004503 G-X-X-G motif; other site 167555004504 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 167555004505 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 167555004506 putative translocon binding site; other site 167555004507 protein-rRNA interface [nucleotide binding]; other site 167555004508 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 167555004509 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 167555004510 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 167555004511 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 167555004512 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 167555004513 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 167555004514 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 167555004515 NADH-quinone oxidoreductase cyanobacterial subunit N; Region: NdhN; pfam11909 167555004516 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 167555004517 Iron-Sulfur binding protein C terminal; Region: LdpA_C; pfam12617 167555004518 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 167555004519 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 167555004520 RecA/RadA recombinase [DNA replication, recombination, and repair]; Region: RecA; COG0468 167555004521 hexamer interface [polypeptide binding]; other site 167555004522 Walker A motif; other site 167555004523 ATP binding site [chemical binding]; other site 167555004524 Walker B motif; other site 167555004525 Protein of unknown function (DUF2839); Region: DUF2839; pfam10999 167555004526 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 167555004527 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 167555004528 arogenate dehydrogenase; Reviewed; Region: PRK07417 167555004529 prephenate dehydrogenase; Validated; Region: PRK08507 167555004530 C-3',4' desaturase CrtD; Region: desat_CrtD; TIGR02733 167555004531 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 167555004532 Fructosamine kinase; Region: Fructosamin_kin; cl17579 167555004533 Domain of unknown function (DUF4308); Region: DUF4308; pfam14159 167555004534 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 167555004535 MPN+ (JAMM) motif; other site 167555004536 Zinc-binding site [ion binding]; other site 167555004537 hypothetical protein; Validated; Region: PRK07411 167555004538 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 167555004539 ATP binding site [chemical binding]; other site 167555004540 substrate interface [chemical binding]; other site 167555004541 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 167555004542 active site residue [active] 167555004543 hypothetical protein; Validated; Region: PRK07413 167555004544 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 167555004545 homodimer interface [polypeptide binding]; other site 167555004546 Walker A motif; other site 167555004547 ATP binding site [chemical binding]; other site 167555004548 hydroxycobalamin binding site [chemical binding]; other site 167555004549 Walker B motif; other site 167555004550 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; pfam02572 167555004551 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 167555004552 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 167555004553 Ligand Binding Site [chemical binding]; other site 167555004554 S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK02770 167555004555 recombination protein F; Reviewed; Region: recF; PRK00064 167555004556 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 167555004557 Walker A/P-loop; other site 167555004558 ATP binding site [chemical binding]; other site 167555004559 Q-loop/lid; other site 167555004560 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 167555004561 ABC transporter signature motif; other site 167555004562 Walker B; other site 167555004563 D-loop; other site 167555004564 H-loop/switch region; other site 167555004565 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 167555004566 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 167555004567 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 167555004568 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 167555004569 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 167555004570 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 167555004571 PsaD; Region: PsaD; pfam02531 167555004572 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 167555004573 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 167555004574 dimer interface [polypeptide binding]; other site 167555004575 phosphorylation site [posttranslational modification] 167555004576 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 167555004577 Domain of unknown function DUF59; Region: DUF59; pfam01883 167555004578 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 167555004579 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 167555004580 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 167555004581 Protein of unknown function (DUF3529); Region: DUF3529; pfam12046 167555004582 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 167555004583 catalytic site [active] 167555004584 putative active site [active] 167555004585 putative substrate binding site [chemical binding]; other site 167555004586 conserved hypothetical protein; Region: TIGR03492 167555004587 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370 167555004588 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 167555004589 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 167555004590 active site 167555004591 catalytic tetrad [active] 167555004592 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 167555004593 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 167555004594 dimerization interface [polypeptide binding]; other site 167555004595 putative ATP binding site [chemical binding]; other site 167555004596 bifunctional pantoate ligase/cytidylate kinase; Provisional; Region: PRK13477 167555004597 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 167555004598 active site 167555004599 nucleotide binding site [chemical binding]; other site 167555004600 HIGH motif; other site 167555004601 KMSKS motif; other site 167555004602 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 167555004603 CMP-binding site; other site 167555004604 The sites determining sugar specificity; other site 167555004605 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 167555004606 Low molecular weight phosphatase family; Region: LMWPc; cd00115 167555004607 active site 167555004608 phycoerythrobilin:ferredoxin oxidoreductase; Provisional; Region: PRK13249 167555004609 dihydrobiliverdin:ferredoxin oxidoreductase; Provisional; Region: PRK13247 167555004610 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 167555004611 heme binding pocket [chemical binding]; other site 167555004612 heme ligand [chemical binding]; other site 167555004613 isocitrate dehydrogenase; Validated; Region: PRK07362 167555004614 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 167555004615 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 167555004616 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 167555004617 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 167555004618 phosphate binding site [ion binding]; other site 167555004619 Aldose 1-epimerase, similar to Synechocystis Slr1438; Region: Aldose_epim_Slr1438; cd09025 167555004620 active site 167555004621 catalytic residues [active] 167555004622 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 167555004623 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 167555004624 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 167555004625 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 167555004626 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 167555004627 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 167555004628 homodimer interface [polypeptide binding]; other site 167555004629 active site pocket [active] 167555004630 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 167555004631 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 167555004632 dimerization interface [polypeptide binding]; other site 167555004633 active site 167555004634 metal binding site [ion binding]; metal-binding site 167555004635 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 167555004636 dsRNA binding site [nucleotide binding]; other site 167555004637 Protein of unknown function (DUF3252); Region: DUF3252; pfam11623 167555004638 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 167555004639 RimM N-terminal domain; Region: RimM; pfam01782 167555004640 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 167555004641 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 167555004642 Substrate binding site; other site 167555004643 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 167555004644 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 167555004645 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 167555004646 glutaminase active site [active] 167555004647 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 167555004648 dimer interface [polypeptide binding]; other site 167555004649 active site 167555004650 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 167555004651 dimer interface [polypeptide binding]; other site 167555004652 active site 167555004653 photosystem I subunit VII; Region: psaC; CHL00065 167555004654 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 167555004655 acyl carrier protein; Provisional; Region: acpP; PRK00982 167555004656 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 167555004657 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 167555004658 dimer interface [polypeptide binding]; other site 167555004659 active site 167555004660 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 167555004661 transketolase; Region: PLN02790 167555004662 TPP-binding site [chemical binding]; other site 167555004663 dimer interface [polypeptide binding]; other site 167555004664 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 167555004665 PYR/PP interface [polypeptide binding]; other site 167555004666 dimer interface [polypeptide binding]; other site 167555004667 TPP binding site [chemical binding]; other site 167555004668 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 167555004669 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 167555004670 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 167555004671 Protein of unknown function (DUF3188); Region: DUF3188; pfam11384 167555004672 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 167555004673 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 167555004674 metal binding site [ion binding]; metal-binding site 167555004675 dimer interface [polypeptide binding]; other site 167555004676 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 167555004677 binding surface 167555004678 TPR motif; other site 167555004679 TPR repeat; Region: TPR_11; pfam13414 167555004680 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 167555004681 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167555004682 Walker A motif; other site 167555004683 ATP binding site [chemical binding]; other site 167555004684 Walker B motif; other site 167555004685 arginine finger; other site 167555004686 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 167555004687 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 167555004688 SmpB-tmRNA interface; other site 167555004689 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 167555004690 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 167555004691 dimer interface [polypeptide binding]; other site 167555004692 putative anticodon binding site; other site 167555004693 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 167555004694 motif 1; other site 167555004695 active site 167555004696 motif 2; other site 167555004697 motif 3; other site 167555004698 Ycf27; Reviewed; Region: orf27; CHL00148 167555004699 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 167555004700 active site 167555004701 phosphorylation site [posttranslational modification] 167555004702 intermolecular recognition site; other site 167555004703 dimerization interface [polypeptide binding]; other site 167555004704 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 167555004705 DNA binding site [nucleotide binding] 167555004706 rod shape-determining protein MreC; Provisional; Region: PRK13922 167555004707 rod shape-determining protein MreC; Region: MreC; pfam04085 167555004708 rod shape-determining protein MreB; Provisional; Region: PRK13927 167555004709 MreB and similar proteins; Region: MreB_like; cd10225 167555004710 nucleotide binding site [chemical binding]; other site 167555004711 Mg binding site [ion binding]; other site 167555004712 putative protofilament interaction site [polypeptide binding]; other site 167555004713 RodZ interaction site [polypeptide binding]; other site 167555004714 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 167555004715 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 167555004716 dimer interface [polypeptide binding]; other site 167555004717 ssDNA binding site [nucleotide binding]; other site 167555004718 tetramer (dimer of dimers) interface [polypeptide binding]; other site 167555004719 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 167555004720 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 167555004721 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 167555004722 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 167555004723 homotetramer interface [polypeptide binding]; other site 167555004724 ligand binding site [chemical binding]; other site 167555004725 catalytic site [active] 167555004726 NAD binding site [chemical binding]; other site 167555004727 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; pfam02367 167555004728 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 167555004729 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 167555004730 putative substrate binding site [chemical binding]; other site 167555004731 putative ATP binding site [chemical binding]; other site 167555004732 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 167555004733 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 167555004734 minor groove reading motif; other site 167555004735 helix-hairpin-helix signature motif; other site 167555004736 substrate binding pocket [chemical binding]; other site 167555004737 active site 167555004738 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 167555004739 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 167555004740 active site 167555004741 8-oxo-dGMP binding site [chemical binding]; other site 167555004742 nudix motif; other site 167555004743 metal binding site [ion binding]; metal-binding site 167555004744 hydrolase, alpha/beta fold family protein; Region: PLN02824 167555004745 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 167555004746 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 167555004747 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 167555004748 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 167555004749 Sigma-70, region 4; Region: Sigma70_r4; pfam04545 167555004750 Mg2+ transporter (mgtE); Region: mgtE; TIGR00400 167555004751 MgtE intracellular N domain; Region: MgtE_N; smart00924 167555004752 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 167555004753 Divalent cation transporter; Region: MgtE; pfam01769 167555004754 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 167555004755 catalytic residues [active] 167555004756 dimer interface [polypeptide binding]; other site 167555004757 CrcB-like protein; Region: CRCB; pfam02537 167555004758 CrcB-like protein; Region: CRCB; pfam02537 167555004759 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 167555004760 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 167555004761 ATP binding site [chemical binding]; other site 167555004762 Mg2+ binding site [ion binding]; other site 167555004763 G-X-G motif; other site 167555004764 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 167555004765 anchoring element; other site 167555004766 dimer interface [polypeptide binding]; other site 167555004767 ATP binding site [chemical binding]; other site 167555004768 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 167555004769 active site 167555004770 putative metal-binding site [ion binding]; other site 167555004771 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 167555004772 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 167555004773 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 167555004774 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 167555004775 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 167555004776 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 167555004777 Predicted transcriptional regulators [Transcription]; Region: COG1725 167555004778 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 167555004779 DNA-binding site [nucleotide binding]; DNA binding site 167555004780 serine O-acetyltransferase; Region: cysE; TIGR01172 167555004781 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 167555004782 trimer interface [polypeptide binding]; other site 167555004783 active site 167555004784 substrate binding site [chemical binding]; other site 167555004785 CoA binding site [chemical binding]; other site 167555004786 Dam-replacing family; Region: DRP; pfam06044 167555004787 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 167555004788 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 167555004789 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 167555004790 Walker A/P-loop; other site 167555004791 ATP binding site [chemical binding]; other site 167555004792 Q-loop/lid; other site 167555004793 ABC transporter signature motif; other site 167555004794 Walker B; other site 167555004795 D-loop; other site 167555004796 H-loop/switch region; other site 167555004797 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12902 167555004798 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 167555004799 ATP binding site [chemical binding]; other site 167555004800 putative Mg++ binding site [ion binding]; other site 167555004801 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 167555004802 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 167555004803 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 167555004804 NADP-binding site; other site 167555004805 homotetramer interface [polypeptide binding]; other site 167555004806 substrate binding site [chemical binding]; other site 167555004807 homodimer interface [polypeptide binding]; other site 167555004808 active site 167555004809 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 167555004810 active site 167555004811 Domain of unknown function (DUF4214); Region: DUF4214; pfam13946 167555004812 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 167555004813 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 167555004814 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 167555004815 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 167555004816 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259 167555004817 putative active site [active] 167555004818 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 167555004819 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 167555004820 Walker A/P-loop; other site 167555004821 ATP binding site [chemical binding]; other site 167555004822 Q-loop/lid; other site 167555004823 ABC transporter signature motif; other site 167555004824 Walker B; other site 167555004825 D-loop; other site 167555004826 H-loop/switch region; other site 167555004827 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 167555004828 HlyD family secretion protein; Region: HlyD_3; pfam13437 167555004829 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 167555004830 This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818 167555004831 putative ADP-binding pocket [chemical binding]; other site 167555004832 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 167555004833 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 167555004834 Domain of unknown function (DUF4214); Region: DUF4214; pfam13946 167555004835 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 167555004836 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 167555004837 NADP-binding site; other site 167555004838 homotetramer interface [polypeptide binding]; other site 167555004839 substrate binding site [chemical binding]; other site 167555004840 homodimer interface [polypeptide binding]; other site 167555004841 active site 167555004842 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 167555004843 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 167555004844 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 167555004845 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 167555004846 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 167555004847 Methyltransferase domain; Region: Methyltransf_23; pfam13489 167555004848 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 167555004849 S-adenosylmethionine binding site [chemical binding]; other site 167555004850 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 167555004851 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 167555004852 substrate binding site; other site 167555004853 tetramer interface; other site 167555004854 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 167555004855 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 167555004856 homopentamer interface [polypeptide binding]; other site 167555004857 active site 167555004858 photosystem II core protein PsbZ; Region: PS_II_psbZ; TIGR03043 167555004859 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 167555004860 MutS domain I; Region: MutS_I; pfam01624 167555004861 MutS domain II; Region: MutS_II; pfam05188 167555004862 MutS domain III; Region: MutS_III; pfam05192 167555004863 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 167555004864 Walker A/P-loop; other site 167555004865 ATP binding site [chemical binding]; other site 167555004866 Q-loop/lid; other site 167555004867 ABC transporter signature motif; other site 167555004868 Walker B; other site 167555004869 D-loop; other site 167555004870 H-loop/switch region; other site 167555004871 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 167555004872 Precorrin-8X methylmutase; Region: CbiC; pfam02570 167555004873 DNA polymerase III subunit delta; Validated; Region: PRK07452 167555004874 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 167555004875 aspartate kinase; Provisional; Region: PRK07431 167555004876 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 167555004877 putative nucleotide binding site [chemical binding]; other site 167555004878 putative catalytic residues [active] 167555004879 putative Mg ion binding site [ion binding]; other site 167555004880 putative aspartate binding site [chemical binding]; other site 167555004881 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 167555004882 putative allosteric regulatory site; other site 167555004883 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 167555004884 putative allosteric regulatory residue; other site 167555004885 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 167555004886 putative allosteric regulatory site; other site 167555004887 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 167555004888 excinuclease ABC subunit B; Provisional; Region: PRK05298 167555004889 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 167555004890 ATP binding site [chemical binding]; other site 167555004891 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 167555004892 nucleotide binding region [chemical binding]; other site 167555004893 ATP-binding site [chemical binding]; other site 167555004894 Ultra-violet resistance protein B; Region: UvrB; pfam12344 167555004895 UvrB/uvrC motif; Region: UVR; pfam02151 167555004896 Protein of unknown function (DUF561); Region: DUF561; pfam04481 167555004897 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 167555004898 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 167555004899 Ligand Binding Site [chemical binding]; other site 167555004900 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 167555004901 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 167555004902 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 167555004903 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 167555004904 dihydrodipicolinate synthase; Region: dapA; TIGR00674 167555004905 dimer interface [polypeptide binding]; other site 167555004906 active site 167555004907 catalytic residue [active] 167555004908 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 167555004909 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 167555004910 trigger factor; Provisional; Region: tig; PRK01490 167555004911 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 167555004912 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 167555004913 Clp protease; Region: CLP_protease; pfam00574 167555004914 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 167555004915 oligomer interface [polypeptide binding]; other site 167555004916 active site residues [active] 167555004917 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 167555004918 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 167555004919 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 167555004920 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167555004921 Walker A motif; other site 167555004922 ATP binding site [chemical binding]; other site 167555004923 Walker B motif; other site 167555004924 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 167555004925 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14948 167555004926 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 167555004927 Walker A motif; other site 167555004928 ATP binding site [chemical binding]; other site 167555004929 Walker B motif; other site 167555004930 arginine finger; other site 167555004931 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 167555004932 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 167555004933 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 167555004934 DXD motif; other site 167555004935 Sporulation related domain; Region: SPOR; cl10051 167555004936 Stage II sporulation protein; Region: SpoIID; pfam08486 167555004937 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 167555004938 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 167555004939 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 167555004940 23S rRNA binding site [nucleotide binding]; other site 167555004941 L21 binding site [polypeptide binding]; other site 167555004942 L13 binding site [polypeptide binding]; other site 167555004943 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 167555004944 binding surface 167555004945 TPR motif; other site 167555004946 TPR repeat; Region: TPR_11; pfam13414 167555004947 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 167555004948 ThiS interaction site; other site 167555004949 putative active site [active] 167555004950 tetramer interface [polypeptide binding]; other site 167555004951 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 167555004952 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 167555004953 NAD(P) binding site [chemical binding]; other site 167555004954 active site 167555004955 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 167555004956 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 167555004957 glycine dehydrogenase; Provisional; Region: PRK05367 167555004958 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 167555004959 tetramer interface [polypeptide binding]; other site 167555004960 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167555004961 catalytic residue [active] 167555004962 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 167555004963 tetramer interface [polypeptide binding]; other site 167555004964 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167555004965 catalytic residue [active] 167555004966 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 167555004967 lipoyl attachment site [posttranslational modification]; other site 167555004968 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 167555004969 Aluminium resistance protein; Region: Alum_res; pfam06838 167555004970 Fatty acid desaturase; Region: FA_desaturase; pfam00487 167555004971 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 167555004972 Di-iron ligands [ion binding]; other site 167555004973 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 167555004974 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 167555004975 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 167555004976 replicative DNA helicase; Region: DnaB; TIGR00665 167555004977 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 167555004978 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 167555004979 Walker A motif; other site 167555004980 ATP binding site [chemical binding]; other site 167555004981 Walker B motif; other site 167555004982 DNA binding loops [nucleotide binding] 167555004983 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 167555004984 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 167555004985 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 167555004986 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 167555004987 Protein of unknown function (DUF98); Region: DUF98; pfam01947 167555004988 SprT-like family; Region: SprT-like; pfam10263 167555004989 SprT homologues; Region: SprT; cl01182 167555004990 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 167555004991 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 167555004992 nucleotide binding pocket [chemical binding]; other site 167555004993 K-X-D-G motif; other site 167555004994 catalytic site [active] 167555004995 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 167555004996 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 167555004997 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 167555004998 Dimer interface [polypeptide binding]; other site 167555004999 BRCT sequence motif; other site 167555005000 Uncharacterized conserved protein [Function unknown]; Region: COG0398 167555005001 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 167555005002 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 167555005003 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 167555005004 active site 167555005005 HIGH motif; other site 167555005006 nucleotide binding site [chemical binding]; other site 167555005007 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 167555005008 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 167555005009 active site 167555005010 KMSKS motif; other site 167555005011 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 167555005012 tRNA binding surface [nucleotide binding]; other site 167555005013 anticodon binding site; other site 167555005014 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 167555005015 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 167555005016 homodimer interface [polypeptide binding]; other site 167555005017 MazG family protein; Region: mazG; TIGR00444 167555005018 metal binding site [ion binding]; metal-binding site 167555005019 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 167555005020 homodimer interface [polypeptide binding]; other site 167555005021 active site 167555005022 putative chemical substrate binding site [chemical binding]; other site 167555005023 metal binding site [ion binding]; metal-binding site 167555005024 spermidine synthase; Provisional; Region: PRK00811 167555005025 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 167555005026 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 167555005027 agmatinase; Region: agmatinase; TIGR01230 167555005028 putative active site [active] 167555005029 Mn binding site [ion binding]; other site 167555005030 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 167555005031 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 167555005032 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 167555005033 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 167555005034 dimer interface [polypeptide binding]; other site 167555005035 anticodon binding site; other site 167555005036 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 167555005037 homodimer interface [polypeptide binding]; other site 167555005038 motif 1; other site 167555005039 active site 167555005040 motif 2; other site 167555005041 GAD domain; Region: GAD; pfam02938 167555005042 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 167555005043 active site 167555005044 motif 3; other site 167555005045 CTP synthetase; Validated; Region: pyrG; PRK05380 167555005046 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 167555005047 Catalytic site [active] 167555005048 active site 167555005049 UTP binding site [chemical binding]; other site 167555005050 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 167555005051 active site 167555005052 putative oxyanion hole; other site 167555005053 catalytic triad [active] 167555005054 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 167555005055 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 167555005056 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 167555005057 Ligand Binding Site [chemical binding]; other site 167555005058 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 167555005059 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 167555005060 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 167555005061 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 167555005062 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 167555005063 homodimer interface [polypeptide binding]; other site 167555005064 substrate-cofactor binding pocket; other site 167555005065 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167555005066 catalytic residue [active] 167555005067 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 167555005068 active site 167555005069 SAM binding site [chemical binding]; other site 167555005070 homodimer interface [polypeptide binding]; other site 167555005071 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 167555005072 putative active site [active] 167555005073 ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566 167555005074 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 167555005075 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 167555005076 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 167555005077 hypothetical protein; Provisional; Region: PRK07394 167555005078 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 167555005079 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 167555005080 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 167555005081 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 167555005082 Major Facilitator Superfamily; Region: MFS_1; pfam07690 167555005083 putative substrate translocation pore; other site 167555005084 polyphosphate kinase; Provisional; Region: PRK05443 167555005085 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 167555005086 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 167555005087 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 167555005088 putative domain interface [polypeptide binding]; other site 167555005089 putative active site [active] 167555005090 catalytic site [active] 167555005091 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 167555005092 putative domain interface [polypeptide binding]; other site 167555005093 putative active site [active] 167555005094 catalytic site [active] 167555005095 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 167555005096 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 167555005097 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 167555005098 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 167555005099 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 167555005100 DNA binding residues [nucleotide binding] 167555005101 Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170 167555005102 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 167555005103 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 167555005104 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 167555005105 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 167555005106 substrate binding site [chemical binding]; other site 167555005107 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 167555005108 substrate binding site [chemical binding]; other site 167555005109 ligand binding site [chemical binding]; other site 167555005110 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 167555005111 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 167555005112 Cl- selectivity filter; other site 167555005113 Cl- binding residues [ion binding]; other site 167555005114 pore gating glutamate residue; other site 167555005115 dimer interface [polypeptide binding]; other site 167555005116 H+/Cl- coupling transport residue; other site 167555005117 O-Antigen ligase; Region: Wzy_C; pfam04932 167555005118 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 167555005119 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 167555005120 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 167555005121 putative active site [active] 167555005122 putative substrate binding site [chemical binding]; other site 167555005123 putative cosubstrate binding site; other site 167555005124 catalytic site [active] 167555005125 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 167555005126 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 167555005127 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 167555005128 nucleotide binding site [chemical binding]; other site 167555005129 NEF interaction site [polypeptide binding]; other site 167555005130 SBD interface [polypeptide binding]; other site 167555005131 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 167555005132 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 167555005133 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 167555005134 shikimate binding site; other site 167555005135 NAD(P) binding site [chemical binding]; other site 167555005136 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 167555005137 argininosuccinate synthase; Provisional; Region: PRK13820 167555005138 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 167555005139 ANP binding site [chemical binding]; other site 167555005140 Substrate Binding Site II [chemical binding]; other site 167555005141 Substrate Binding Site I [chemical binding]; other site 167555005142 Protein of unknown function (DUF3134); Region: DUF3134; pfam11332 167555005143 phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445 167555005144 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 167555005145 Mg++ binding site [ion binding]; other site 167555005146 putative catalytic motif [active] 167555005147 putative substrate binding site [chemical binding]; other site 167555005148 sucrose-phosphate synthase, putative, glycosyltransferase domain; Region: sucr_P_syn_N; TIGR02472 167555005149 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 167555005150 putative ADP-binding pocket [chemical binding]; other site 167555005151 sucrose phosphate synthase, sucrose phosphatase-like domain, bacterial; Region: sucr_syn_bact_C; TIGR02471 167555005152 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 167555005153 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 167555005154 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 167555005155 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 167555005156 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 167555005157 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 167555005158 Walker A/P-loop; other site 167555005159 ATP binding site [chemical binding]; other site 167555005160 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 167555005161 ABC transporter signature motif; other site 167555005162 Walker B; other site 167555005163 D-loop; other site 167555005164 H-loop/switch region; other site 167555005165 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 167555005166 ABC1 family; Region: ABC1; cl17513 167555005167 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 167555005168 active site 167555005169 ATP binding site [chemical binding]; other site 167555005170 substrate binding site [chemical binding]; other site 167555005171 activation loop (A-loop); other site 167555005172 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 167555005173 threonine synthase; Reviewed; Region: PRK06721 167555005174 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 167555005175 homodimer interface [polypeptide binding]; other site 167555005176 pyridoxal 5'-phosphate binding site [chemical binding]; other site 167555005177 catalytic residue [active]