-- dump date   	20140620_000439
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
59920000001	DNA polymerase III subunit beta; Validated; Region: PRK05643
59920000002	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
59920000003	putative DNA binding surface [nucleotide binding]; other site
59920000004	dimer interface [polypeptide binding]; other site
59920000005	beta-clamp/clamp loader binding surface; other site
59920000006	beta-clamp/translesion DNA polymerase binding surface; other site
59920000007	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
59920000008	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
59920000009	dimerization interface [polypeptide binding]; other site
59920000010	ATP binding site [chemical binding]; other site
59920000011	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
59920000012	dimerization interface [polypeptide binding]; other site
59920000013	ATP binding site [chemical binding]; other site
59920000014	amidophosphoribosyltransferase; Provisional; Region: PRK09246
59920000015	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
59920000016	active site
59920000017	tetramer interface [polypeptide binding]; other site
59920000018	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
59920000019	active site
59920000020	Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit [DNA replication, recombination, and repair]; Region: GyrA; COG0188
59920000021	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
59920000022	CAP-like domain; other site
59920000023	active site
59920000024	primary dimer interface [polypeptide binding]; other site
59920000025	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
59920000026	binding surface
59920000027	TPR motif; other site
59920000028	TPR repeat; Region: TPR_11; pfam13414
59920000029	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
59920000030	binding surface
59920000031	Tetratricopeptide repeat; Region: TPR_16; pfam13432
59920000032	TPR motif; other site
59920000033	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
59920000034	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
59920000035	Uncharacterized conserved protein [Function unknown]; Region: COG2928
59920000036	transcription antitermination protein NusB; Provisional; Region: nusB; PRK09634
59920000037	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
59920000038	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
59920000039	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
59920000040	P loop; other site
59920000041	GTP binding site [chemical binding]; other site
59920000042	GAF domain; Region: GAF; cl17456
59920000043	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
59920000044	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
59920000045	argininosuccinate lyase; Provisional; Region: PRK00855
59920000046	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
59920000047	active sites [active]
59920000048	tetramer interface [polypeptide binding]; other site
59920000049	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
59920000050	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
59920000051	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
59920000052	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
59920000053	FMN binding site [chemical binding]; other site
59920000054	active site
59920000055	catalytic residues [active]
59920000056	substrate binding site [chemical binding]; other site
59920000057	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841
59920000058	SelR domain; Region: SelR; pfam01641
59920000059	GrpE; Region: GrpE; pfam01025
59920000060	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
59920000061	dimer interface [polypeptide binding]; other site
59920000062	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
59920000063	chaperone protein DnaJ; Provisional; Region: PRK14293
59920000064	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
59920000065	HSP70 interaction site [polypeptide binding]; other site
59920000066	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
59920000067	substrate binding site [polypeptide binding]; other site
59920000068	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
59920000069	Zn binding sites [ion binding]; other site
59920000070	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
59920000071	dimer interface [polypeptide binding]; other site
59920000072	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
59920000073	CPxP  motif; other site
59920000074	Predicted GTPases [General function prediction only]; Region: COG1162
59920000075	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
59920000076	RNA binding site [nucleotide binding]; other site
59920000077	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
59920000078	GTPase/Zn-binding domain interface [polypeptide binding]; other site
59920000079	GTP/Mg2+ binding site [chemical binding]; other site
59920000080	G4 box; other site
59920000081	G5 box; other site
59920000082	G1 box; other site
59920000083	Switch I region; other site
59920000084	G2 box; other site
59920000085	G3 box; other site
59920000086	Switch II region; other site
59920000087	hypothetical protein; Validated; Region: PRK00153
59920000088	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
59920000089	FAD binding domain; Region: FAD_binding_4; pfam01565
59920000090	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
59920000091	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
59920000092	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
59920000093	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
59920000094	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
59920000095	glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK07403
59920000096	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
59920000097	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
59920000098	thiamine monophosphate kinase; Provisional; Region: PRK05731
59920000099	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
59920000100	ATP binding site [chemical binding]; other site
59920000101	dimerization interface [polypeptide binding]; other site
59920000102	cyclophilin_TLP40_like: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) similar ot the Spinach thylakoid lumen protein TLP40. Compared to the archetypal cyclophilin Human cyclophilin A, these proteins have similar peptidylprolyl...; Region: cyclophilin_TLP40_like; cd01924
59920000103	active site
59920000104	elongation factor P; Validated; Region: PRK00529
59920000105	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
59920000106	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
59920000107	RNA binding site [nucleotide binding]; other site
59920000108	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
59920000109	RNA binding site [nucleotide binding]; other site
59920000110	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
59920000111	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
59920000112	carboxyltransferase (CT) interaction site; other site
59920000113	biotinylation site [posttranslational modification]; other site
59920000114	4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK02746
59920000115	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
59920000116	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
59920000117	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
59920000118	putative NAD(P) binding site [chemical binding]; other site
59920000119	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
59920000120	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
59920000121	active site
59920000122	Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451
59920000123	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
59920000124	homodimer interface [polypeptide binding]; other site
59920000125	pyridoxal 5'-phosphate binding site [chemical binding]; other site
59920000126	catalytic residue [active]
59920000127	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
59920000128	GMP synthase; Reviewed; Region: guaA; PRK00074
59920000129	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
59920000130	AMP/PPi binding site [chemical binding]; other site
59920000131	candidate oxyanion hole; other site
59920000132	catalytic triad [active]
59920000133	potential glutamine specificity residues [chemical binding]; other site
59920000134	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
59920000135	ATP Binding subdomain [chemical binding]; other site
59920000136	Ligand Binding sites [chemical binding]; other site
59920000137	Dimerization subdomain; other site
59920000138	Methyltransferase domain; Region: Methyltransf_31; pfam13847
59920000139	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
59920000140	S-adenosylmethionine binding site [chemical binding]; other site
59920000141	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
59920000142	binding surface
59920000143	TPR repeat; Region: TPR_11; pfam13414
59920000144	TPR motif; other site
59920000145	TPR repeat; Region: TPR_11; pfam13414
59920000146	Methyltransferase domain; Region: Methyltransf_24; pfam13578
59920000147	Ion transport protein; Region: Ion_trans; pfam00520
59920000148	Ion channel; Region: Ion_trans_2; pfam07885
59920000149	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
59920000150	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
59920000151	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
59920000152	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
59920000153	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
59920000154	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
59920000155	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
59920000156	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
59920000157	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
59920000158	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
59920000159	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
59920000160	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
59920000161	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
59920000162	motif 1; other site
59920000163	active site
59920000164	motif 2; other site
59920000165	motif 3; other site
59920000166	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
59920000167	arginine decarboxylase; Provisional; Region: PRK05354
59920000168	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
59920000169	dimer interface [polypeptide binding]; other site
59920000170	active site
59920000171	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
59920000172	catalytic residues [active]
59920000173	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
59920000174	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
59920000175	active site
59920000176	multimer interface [polypeptide binding]; other site
59920000177	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
59920000178	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
59920000179	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
59920000180	GatB domain; Region: GatB_Yqey; smart00845
59920000181	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
59920000182	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
59920000183	CoA-binding site [chemical binding]; other site
59920000184	ATP-binding [chemical binding]; other site
59920000185	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
59920000186	heterotetramer interface [polypeptide binding]; other site
59920000187	active site pocket [active]
59920000188	cleavage site
59920000189	Domain of unknown function (DUF4214); Region: DUF4214; pfam13946
59920000190	Domain of unknown function (DUF4214); Region: DUF4214; pfam13946
59920000191	Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509
59920000192	Domain of unknown function (DUF4214); Region: DUF4214; pfam13946
59920000193	Domain of unknown function (DUF4214); Region: DUF4214; pfam13946
59920000194	Protein of unknown function (DUF861); Region: Cupin_3; pfam05899
59920000195	A bacterial subgroup of the C-type lectin-like (CTLD) domain; a subgroup of bacterial protein domains homologous to the carbohydrate-recognition domains (CRDs) of the C-type lectins; Region: CLECT_VCBS; cd03603
59920000196	ligand binding surface [chemical binding]; other site
59920000197	Domain of unknown function (DUF4214); Region: DUF4214; pfam13946
59920000198	Domain of unknown function (DUF4214); Region: DUF4214; pfam13946
59920000199	cyanate hydratase; Validated; Region: PRK02866
59920000200	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
59920000201	non-specific DNA binding site [nucleotide binding]; other site
59920000202	salt bridge; other site
59920000203	sequence-specific DNA binding site [nucleotide binding]; other site
59920000204	Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate.  It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559
59920000205	oligomer interface [polypeptide binding]; other site
59920000206	active site
59920000207	Domain of unknown function (DUF4214); Region: DUF4214; pfam13946
59920000208	Domain of unknown function (DUF4214); Region: DUF4214; pfam13946
59920000209	Domain of unknown function (DUF4214); Region: DUF4214; pfam13946
59920000210	Domain of unknown function (DUF4214); Region: DUF4214; pfam13946
59920000211	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
59920000212	Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996
59920000213	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197
59920000214	active site
59920000215	Domain of unknown function (DUF4214); Region: DUF4214; pfam13946
59920000216	Domain of unknown function (DUF4214); Region: DUF4214; pfam13946
59920000217	putative high light inducible protein; Region: PHA02337
59920000218	C factor cell-cell signaling protein; Provisional; Region: PRK09009
59920000219	carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325
59920000220	NADP binding site [chemical binding]; other site
59920000221	homodimer interface [polypeptide binding]; other site
59920000222	active site
59920000223	SAM (Sterile alpha motif ); Region: SAM_superfamily; cl15755
59920000224	ParA-like protein; Provisional; Region: PHA02518
59920000225	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
59920000226	P-loop; other site
59920000227	Magnesium ion binding site [ion binding]; other site
59920000228	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
59920000229	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
59920000230	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
59920000231	Walker A/P-loop; other site
59920000232	ATP binding site [chemical binding]; other site
59920000233	Q-loop/lid; other site
59920000234	ABC transporter signature motif; other site
59920000235	Walker B; other site
59920000236	D-loop; other site
59920000237	H-loop/switch region; other site
59920000238	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
59920000239	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
59920000240	Protein of unknown function (DUF3303); Region: DUF3303; pfam11746
59920000241	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
59920000242	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
59920000243	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
59920000244	Protein of unknown function (DUF1469); Region: DUF1469; pfam07332
59920000245	DNA polymerase Ligase (LigD); Region: LigD_N; pfam13298
59920000246	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
59920000247	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
59920000248	Walker A/P-loop; other site
59920000249	ATP binding site [chemical binding]; other site
59920000250	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
59920000251	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
59920000252	ABC transporter signature motif; other site
59920000253	Walker B; other site
59920000254	D-loop; other site
59920000255	H-loop/switch region; other site
59920000256	PRC-barrel domain; Region: PRC; pfam05239
59920000257	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
59920000258	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
59920000259	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
59920000260	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
59920000261	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
59920000262	YGGT family; Region: YGGT; pfam02325
59920000263	Ycf66 protein N-terminus; Region: Ycf66_N; pfam07444
59920000264	Protein of unknown function (DUF1509); Region: DUF1509; pfam07420
59920000265	Chlorophyll A-B binding protein; Region: Chloroa_b-bind; pfam00504
59920000266	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
59920000267	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
59920000268	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
59920000269	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
59920000270	nucleotide binding site/active site [active]
59920000271	HIT family signature motif; other site
59920000272	catalytic residue [active]
59920000273	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
59920000274	active site
59920000275	catalytic residues [active]
59920000276	metal binding site [ion binding]; metal-binding site
59920000277	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
59920000278	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
59920000279	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
59920000280	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
59920000281	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
59920000282	catalytic residue [active]
59920000283	FeS assembly protein SufD; Region: sufD; TIGR01981
59920000284	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
59920000285	sulfate ABC transporter protein; Validated; Region: ycf16; CHL00131
59920000286	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
59920000287	Walker A/P-loop; other site
59920000288	ATP binding site [chemical binding]; other site
59920000289	Q-loop/lid; other site
59920000290	ABC transporter signature motif; other site
59920000291	Walker B; other site
59920000292	D-loop; other site
59920000293	H-loop/switch region; other site
59920000294	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
59920000295	putative ABC transporter; Region: ycf24; CHL00085
59920000296	Rho termination factor, N-terminal domain; Region: Rho_N; cl06505
59920000297	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330
59920000298	phosphoglucomutase; Region: PLN02307
59920000299	The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757
59920000300	active site
59920000301	substrate binding site [chemical binding]; other site
59920000302	metal binding site [ion binding]; metal-binding site
59920000303	recombination factor protein RarA/unknown domain fusion protein; Reviewed; Region: PRK13341
59920000304	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
59920000305	Walker A motif; other site
59920000306	ATP binding site [chemical binding]; other site
59920000307	Walker B motif; other site
59920000308	arginine finger; other site
59920000309	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
59920000310	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
59920000311	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
59920000312	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
59920000313	catalytic triad [active]
59920000314	Type III pantothenate kinase; Region: Pan_kinase; cl17198
59920000315	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
59920000316	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
59920000317	Active Sites [active]
59920000318	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
59920000319	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
59920000320	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
59920000321	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
59920000322	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
59920000323	transmembrane helices; other site
59920000324	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
59920000325	TrkA-C domain; Region: TrkA_C; pfam02080
59920000326	TrkA-C domain; Region: TrkA_C; pfam02080
59920000327	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
59920000328	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
59920000329	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
59920000330	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
59920000331	TrkA-N domain; Region: TrkA_N; pfam02254
59920000332	TrkA-C domain; Region: TrkA_C; pfam02080
59920000333	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
59920000334	Protein of unknown function (DUF1662); Region: DUF1662; pfam07878
59920000335	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
59920000336	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
59920000337	Walker A/P-loop; other site
59920000338	ATP binding site [chemical binding]; other site
59920000339	Q-loop/lid; other site
59920000340	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
59920000341	ABC transporter; Region: ABC_tran_2; pfam12848
59920000342	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
59920000343	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
59920000344	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
59920000345	protein binding site [polypeptide binding]; other site
59920000346	Protein of unknown function (DUF2973); Region: DUF2973; pfam11189
59920000347	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
59920000348	generic binding surface II; other site
59920000349	generic binding surface I; other site
59920000350	Exonuclease VII, large subunit; Region: Exonuc_VII_L; pfam02601
59920000351	Exonuclease VII small subunit; Region: Exonuc_VII_S; pfam02609
59920000352	Domain found in IF2B/IF5; Region: eIF-5_eIF-2B; cl17014
59920000353	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
59920000354	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
59920000355	Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643
59920000356	active site
59920000357	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
59920000358	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cd00136
59920000359	putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279
59920000360	Protein of unknown function (DUF512); Region: DUF512; pfam04459
59920000361	Protein of unknown function (DUF3120); Region: DUF3120; pfam11318
59920000362	L-aspartate oxidase; Provisional; Region: PRK07395
59920000363	L-aspartate oxidase; Provisional; Region: PRK06175
59920000364	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
59920000365	Vitamin K epoxide reductase (VKOR) family; Region: VKOR; cl01729
59920000366	putative active site [active]
59920000367	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
59920000368	Domain of unknown function (DUF4346); Region: DUF4346; pfam14251
59920000369	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497
59920000370	Protein of unknown function, DUF482; Region: DUF482; pfam04339
59920000371	Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985
59920000372	RibD C-terminal domain; Region: RibD_C; cl17279
59920000373	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
59920000374	active site
59920000375	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
59920000376	active site
59920000377	shikimate kinase; Reviewed; Region: aroK; PRK00131
59920000378	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
59920000379	ADP binding site [chemical binding]; other site
59920000380	magnesium binding site [ion binding]; other site
59920000381	putative shikimate binding site; other site
59920000382	Protein of unknown function (DUF3571); Region: DUF3571; pfam12095
59920000383	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
59920000384	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
59920000385	C-terminal domain interface [polypeptide binding]; other site
59920000386	GSH binding site (G-site) [chemical binding]; other site
59920000387	dimer interface [polypeptide binding]; other site
59920000388	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
59920000389	N-terminal domain interface [polypeptide binding]; other site
59920000390	dimer interface [polypeptide binding]; other site
59920000391	substrate binding pocket (H-site) [chemical binding]; other site
59920000392	Protein of unknown function (DUF751); Region: DUF751; pfam05421
59920000393	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
59920000394	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
59920000395	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
59920000396	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
59920000397	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
59920000398	active site
59920000399	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817
59920000400	putative hydrophobic ligand binding site [chemical binding]; other site
59920000401	9,9'-di-cis-zeta-carotene desaturase; Region: zeta_caro_desat; TIGR02732
59920000402	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
59920000403	Iron-sulfur cluster assembly accessory protein; Region: TIGR00049
59920000404	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
59920000405	binding surface
59920000406	TPR motif; other site
59920000407	atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
59920000408	TIGR01777 family protein; Region: yfcH
59920000409	putative NAD(P) binding site [chemical binding]; other site
59920000410	putative active site [active]
59920000411	Cyanobacterial and plant NDH-1 subunit O; Region: NdhO; pfam11910
59920000412	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
59920000413	HSP70 interaction site [polypeptide binding]; other site
59920000414	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
59920000415	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
59920000416	dimer interface [polypeptide binding]; other site
59920000417	pyridoxal 5'-phosphate binding site [chemical binding]; other site
59920000418	catalytic residue [active]
59920000419	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
59920000420	hypothetical protein; Provisional; Region: PRK13683
59920000421	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
59920000422	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
59920000423	Walker A/P-loop; other site
59920000424	ATP binding site [chemical binding]; other site
59920000425	Q-loop/lid; other site
59920000426	ABC transporter signature motif; other site
59920000427	Walker B; other site
59920000428	D-loop; other site
59920000429	H-loop/switch region; other site
59920000430	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
59920000431	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
59920000432	active site
59920000433	phosphorylation site [posttranslational modification]
59920000434	intermolecular recognition site; other site
59920000435	dimerization interface [polypeptide binding]; other site
59920000436	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
59920000437	DNA binding site [nucleotide binding]
59920000438	DNA polymerase III subunit delta'; Validated; Region: PRK07399
59920000439	DNA polymerase III subunit delta'; Validated; Region: PRK08485
59920000440	thymidylate kinase; Validated; Region: tmk; PRK00698
59920000441	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
59920000442	TMP-binding site; other site
59920000443	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
59920000444	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
59920000445	metal-binding site [ion binding]
59920000446	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
59920000447	photosystem I assembly protein Ycf3; Provisional; Region: PRK02603
59920000448	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
59920000449	binding surface
59920000450	TPR motif; other site
59920000451	DNA repair protein RadA; Provisional; Region: PRK11823
59920000452	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
59920000453	Walker A motif; other site
59920000454	ATP binding site [chemical binding]; other site
59920000455	Walker B motif; other site
59920000456	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
59920000457	Ycf27; Reviewed; Region: orf27; CHL00148
59920000458	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
59920000459	active site
59920000460	phosphorylation site [posttranslational modification]
59920000461	intermolecular recognition site; other site
59920000462	dimerization interface [polypeptide binding]; other site
59920000463	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
59920000464	DNA binding site [nucleotide binding]
59920000465	putative glycerol-3-phosphate acyltransferase PlsX; Provisional; Region: PRK13845
59920000466	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
59920000467	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
59920000468	dimer interface [polypeptide binding]; other site
59920000469	active site
59920000470	CoA binding pocket [chemical binding]; other site
59920000471	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
59920000472	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
59920000473	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
59920000474	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
59920000475	putative acyl-acceptor binding pocket; other site
59920000476	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
59920000477	Hypothetical chloroplast protein Ycf34; Region: Ycf34; pfam10718
59920000478	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
59920000479	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
59920000480	active site
59920000481	NTP binding site [chemical binding]; other site
59920000482	metal binding triad [ion binding]; metal-binding site
59920000483	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
59920000484	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169
59920000485	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
59920000486	active site lid residues [active]
59920000487	substrate binding pocket [chemical binding]; other site
59920000488	catalytic residues [active]
59920000489	substrate-Mg2+ binding site; other site
59920000490	aspartate-rich region 1; other site
59920000491	aspartate-rich region 2; other site
59920000492	phytoene desaturase; Region: phytoene_desat; TIGR02731
59920000493	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
59920000494	Cyanobacterial and plastid NDH-1 subunit M; Region: NdhM; pfam10664
59920000495	Protein of unknown function (DUF3172); Region: DUF3172; pfam11371
59920000496	LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180
59920000497	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
59920000498	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
59920000499	putative dimerization interface [polypeptide binding]; other site
59920000500	Predicted membrane protein [Function unknown]; Region: COG4094
59920000501	NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07376
59920000502	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
59920000503	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
59920000504	NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010
59920000505	NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK02546
59920000506	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
59920000507	ScpA/B protein; Region: ScpA_ScpB; cl00598
59920000508	glucose-1-phosphate adenylyltransferase; Region: glgC; TIGR02091
59920000509	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
59920000510	active site
59920000511	Substrate binding site; other site
59920000512	Mg++ binding site; other site
59920000513	Left-handed parallel beta-Helix (LbH) domain of a group of proteins with similarity to glucose-1-phosphate adenylyltransferase: Included in this family are glucose-1-phosphate adenylyltransferase, mannose-1-phosphate guanylyltransferase, and the...; Region: LbH_G1P_AT_C_like; cd03356
59920000514	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
59920000515	FAD binding site [chemical binding]; other site
59920000516	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
59920000517	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
59920000518	DNA binding residues [nucleotide binding]
59920000519	dimerization interface [polypeptide binding]; other site
59920000520	CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891
59920000521	putative active site [active]
59920000522	putative metal binding residues [ion binding]; other site
59920000523	signature motif; other site
59920000524	putative dimer interface [polypeptide binding]; other site
59920000525	putative phosphate binding site [ion binding]; other site
59920000526	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02645
59920000527	ATP-NAD kinase; Region: NAD_kinase; pfam01513
59920000528	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
59920000529	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
59920000530	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
59920000531	NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213
59920000532	NADH-plastoquinone oxidoreductase subunit I protein; Region: ndhI; TIGR00403
59920000533	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
59920000534	NADH dehydrogenase; Region: NADHdh; cl00469
59920000535	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
59920000536	citrate synthase; Provisional; Region: PRK14036
59920000537	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
59920000538	oxalacetate binding site [chemical binding]; other site
59920000539	citrylCoA binding site [chemical binding]; other site
59920000540	coenzyme A binding site [chemical binding]; other site
59920000541	catalytic triad [active]
59920000542	Protein of unknown function (DUF3352); Region: DUF3352; pfam11832
59920000543	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
59920000544	active site residue [active]
59920000545	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
59920000546	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
59920000547	pyridoxal 5'-phosphate binding site [chemical binding]; other site
59920000548	catalytic residue [active]
59920000549	Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567
59920000550	putative rRNA binding site [nucleotide binding]; other site
59920000551	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
59920000552	ligand-binding site [chemical binding]; other site
59920000553	AIR carboxylase; Region: AIRC; pfam00731
59920000554	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
59920000555	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
59920000556	active site
59920000557	Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580
59920000558	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
59920000559	S-adenosylmethionine binding site [chemical binding]; other site
59920000560	Magnesium-protoporphyrin IX methyltransferase C-terminus; Region: Mg-por_mtran_C; pfam07109
59920000561	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
59920000562	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
59920000563	active site
59920000564	phosphorylation site [posttranslational modification]
59920000565	intermolecular recognition site; other site
59920000566	dimerization interface [polypeptide binding]; other site
59920000567	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
59920000568	DNA binding residues [nucleotide binding]
59920000569	dimerization interface [polypeptide binding]; other site
59920000570	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
59920000571	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
59920000572	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
59920000573	catalytic residue [active]
59920000574	MraW methylase family; Region: Methyltransf_5; cl17771
59920000575	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
59920000576	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
59920000577	NAD(P)H-quinone oxidoreductase subunit H; Validated; Region: PRK07415
59920000578	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
59920000579	active site
59920000580	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
59920000581	active site
59920000582	CoA binding site [chemical binding]; other site
59920000583	AMP binding site [chemical binding]; other site
59920000584	O-succinylbenzoate synthase; Provisional; Region: PRK02714
59920000585	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
59920000586	active site
59920000587	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK07419
59920000588	UbiA prenyltransferase family; Region: UbiA; pfam01040
59920000589	Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169
59920000590	chorismate binding enzyme; Region: Chorismate_bind; cl10555
59920000591	glutathione synthetase; Provisional; Region: PRK05246
59920000592	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
59920000593	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
59920000594	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
59920000595	GSH binding site [chemical binding]; other site
59920000596	catalytic residues [active]
59920000597	peptide chain release factor 2; Provisional; Region: PRK05589
59920000598	This domain is found in peptide chain release factors; Region: PCRF; smart00937
59920000599	RF-1 domain; Region: RF-1; pfam00472
59920000600	Protein of unknown function (DUF3285); Region: DUF3285; pfam11688
59920000601	Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130
59920000602	Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219
59920000603	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
59920000604	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
59920000605	glutamine binding [chemical binding]; other site
59920000606	catalytic triad [active]
59920000607	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
59920000608	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
59920000609	pyridoxal 5'-phosphate binding site [chemical binding]; other site
59920000610	homodimer interface [polypeptide binding]; other site
59920000611	catalytic residue [active]
59920000612	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
59920000613	arginine-tRNA ligase; Region: PLN02286
59920000614	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
59920000615	active site
59920000616	HIGH motif; other site
59920000617	KMSK motif region; other site
59920000618	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
59920000619	tRNA binding surface [nucleotide binding]; other site
59920000620	anticodon binding site; other site
59920000621	Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157
59920000622	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
59920000623	dimerization interface [polypeptide binding]; other site
59920000624	active site
59920000625	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
59920000626	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
59920000627	trmE is a tRNA modification GTPase; Region: trmE; cd04164
59920000628	G1 box; other site
59920000629	GTP/Mg2+ binding site [chemical binding]; other site
59920000630	Switch I region; other site
59920000631	G2 box; other site
59920000632	Switch II region; other site
59920000633	G3 box; other site
59920000634	G4 box; other site
59920000635	G5 box; other site
59920000636	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
59920000637	Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835
59920000638	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
59920000639	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
59920000640	Zn2+ binding site [ion binding]; other site
59920000641	Mg2+ binding site [ion binding]; other site
59920000642	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
59920000643	synthetase active site [active]
59920000644	NTP binding site [chemical binding]; other site
59920000645	metal binding site [ion binding]; metal-binding site
59920000646	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
59920000647	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
59920000648	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
59920000649	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
59920000650	Walker A/P-loop; other site
59920000651	ATP binding site [chemical binding]; other site
59920000652	Q-loop/lid; other site
59920000653	ABC transporter signature motif; other site
59920000654	Walker B; other site
59920000655	D-loop; other site
59920000656	H-loop/switch region; other site
59920000657	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
59920000658	Walker A/P-loop; other site
59920000659	ATP binding site [chemical binding]; other site
59920000660	Q-loop/lid; other site
59920000661	ABC transporter signature motif; other site
59920000662	Walker B; other site
59920000663	D-loop; other site
59920000664	H-loop/switch region; other site
59920000665	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
59920000666	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
59920000667	RNA binding surface [nucleotide binding]; other site
59920000668	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
59920000669	active site
59920000670	GTPase YlqF; Reviewed; Region: rbgA; PRK09563
59920000671	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
59920000672	GTP/Mg2+ binding site [chemical binding]; other site
59920000673	G4 box; other site
59920000674	G5 box; other site
59920000675	G1 box; other site
59920000676	Switch I region; other site
59920000677	G2 box; other site
59920000678	G3 box; other site
59920000679	Switch II region; other site
59920000680	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
59920000681	Phosphoglycerate kinase; Region: PGK; pfam00162
59920000682	substrate binding site [chemical binding]; other site
59920000683	hinge regions; other site
59920000684	ADP binding site [chemical binding]; other site
59920000685	catalytic site [active]
59920000686	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
59920000687	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
59920000688	active site
59920000689	homodimer interface [polypeptide binding]; other site
59920000690	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
59920000691	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
59920000692	pyridoxal 5'-phosphate binding site [chemical binding]; other site
59920000693	homodimer interface [polypeptide binding]; other site
59920000694	catalytic residue [active]
59920000695	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
59920000696	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
59920000697	quinone interaction residues [chemical binding]; other site
59920000698	active site
59920000699	catalytic residues [active]
59920000700	FMN binding site [chemical binding]; other site
59920000701	substrate binding site [chemical binding]; other site
59920000702	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
59920000703	RNA/DNA hybrid binding site [nucleotide binding]; other site
59920000704	active site
59920000705	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
59920000706	L11 interface [polypeptide binding]; other site
59920000707	putative EF-Tu interaction site [polypeptide binding]; other site
59920000708	putative EF-G interaction site [polypeptide binding]; other site
59920000709	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
59920000710	23S rRNA interface [nucleotide binding]; other site
59920000711	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
59920000712	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
59920000713	mRNA/rRNA interface [nucleotide binding]; other site
59920000714	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
59920000715	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
59920000716	23S rRNA interface [nucleotide binding]; other site
59920000717	L7/L12 interface [polypeptide binding]; other site
59920000718	putative thiostrepton binding site; other site
59920000719	L25 interface [polypeptide binding]; other site
59920000720	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
59920000721	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
59920000722	putative homodimer interface [polypeptide binding]; other site
59920000723	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
59920000724	heterodimer interface [polypeptide binding]; other site
59920000725	homodimer interface [polypeptide binding]; other site
59920000726	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
59920000727	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
59920000728	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
59920000729	Walker A motif; other site
59920000730	ATP binding site [chemical binding]; other site
59920000731	Walker B motif; other site
59920000732	arginine finger; other site
59920000733	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
59920000734	Walker A motif; other site
59920000735	ATP binding site [chemical binding]; other site
59920000736	Walker B motif; other site
59920000737	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
59920000738	enolase; Provisional; Region: eno; PRK00077
59920000739	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
59920000740	dimer interface [polypeptide binding]; other site
59920000741	metal binding site [ion binding]; metal-binding site
59920000742	substrate binding pocket [chemical binding]; other site
59920000743	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
59920000744	ABC1 family; Region: ABC1; cl17513
59920000745	ABC1 family; Region: ABC1; cl17513
59920000746	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
59920000747	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
59920000748	Nitrogen regulatory protein P-II; Region: P-II; cl00412
59920000749	Domain of unknown function (DUF897); Region: DUF897; pfam05982
59920000750	high affinity sulphate transporter 1; Region: sulP; TIGR00815
59920000751	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
59920000752	Sulfate transporter family; Region: Sulfate_transp; pfam00916
59920000753	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
59920000754	chaperone protein DnaJ; Provisional; Region: PRK14299
59920000755	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
59920000756	HSP70 interaction site [polypeptide binding]; other site
59920000757	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
59920000758	substrate binding site [polypeptide binding]; other site
59920000759	dimer interface [polypeptide binding]; other site
59920000760	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
59920000761	dimer interface [polypeptide binding]; other site
59920000762	active site
59920000763	aspartate-rich active site metal binding site; other site
59920000764	allosteric magnesium binding site [ion binding]; other site
59920000765	Schiff base residues; other site
59920000766	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
59920000767	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
59920000768	active site
59920000769	metal binding site [ion binding]; metal-binding site
59920000770	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
59920000771	MutS domain III; Region: MutS_III; pfam05192
59920000772	ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280
59920000773	Walker A/P-loop; other site
59920000774	ATP binding site [chemical binding]; other site
59920000775	Q-loop/lid; other site
59920000776	ABC transporter signature motif; other site
59920000777	Walker B; other site
59920000778	D-loop; other site
59920000779	H-loop/switch region; other site
59920000780	Smr domain; Region: Smr; pfam01713
59920000781	GTPase CgtA; Reviewed; Region: obgE; PRK12299
59920000782	GTP1/OBG; Region: GTP1_OBG; pfam01018
59920000783	Obg GTPase; Region: Obg; cd01898
59920000784	G1 box; other site
59920000785	GTP/Mg2+ binding site [chemical binding]; other site
59920000786	Switch I region; other site
59920000787	G2 box; other site
59920000788	G3 box; other site
59920000789	Switch II region; other site
59920000790	G4 box; other site
59920000791	G5 box; other site
59920000792	CP12 domain; Region: CP12; pfam02672
59920000793	Uncharacterized integral membrane protein (DUF2301); Region: DUF2301; pfam10063
59920000794	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
59920000795	putative dimer interface [polypeptide binding]; other site
59920000796	N-terminal domain interface [polypeptide binding]; other site
59920000797	putative substrate binding pocket (H-site) [chemical binding]; other site
59920000798	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
59920000799	Peptidase M14 Aspartoacylase (ASPA) subfamily; Region: M14_ASPA; cd06909
59920000800	active site
59920000801	Zn binding site [ion binding]; other site
59920000802	D1 subunit  of photosystem II (PS II); Region: Photosystem-II_D1; cd09289
59920000803	protein I interface; other site
59920000804	D2 interface; other site
59920000805	protein T interface; other site
59920000806	chlorophyll binding site; other site
59920000807	beta carotene binding site; other site
59920000808	pheophytin binding site; other site
59920000809	manganese-stabilizing polypeptide interface; other site
59920000810	CP43 interface; other site
59920000811	protein L interface; other site
59920000812	oxygen evolving complex binding site; other site
59920000813	bromide binding site; other site
59920000814	quinone binding site; other site
59920000815	Fe binding site [ion binding]; other site
59920000816	core light harvesting interface; other site
59920000817	cytochrome b559 alpha subunit interface; other site
59920000818	cytochrome c-550 interface; other site
59920000819	protein J interface; other site
59920000820	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
59920000821	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
59920000822	Tetramer interface [polypeptide binding]; other site
59920000823	active site
59920000824	FMN-binding site [chemical binding]; other site
59920000825	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
59920000826	active site
59920000827	intersubunit interface [polypeptide binding]; other site
59920000828	catalytic residue [active]
59920000829	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
59920000830	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
59920000831	Walker A motif; other site
59920000832	ATP binding site [chemical binding]; other site
59920000833	Walker B motif; other site
59920000834	arginine finger; other site
59920000835	Peptidase family M41; Region: Peptidase_M41; pfam01434
59920000836	ATP sulphurylase; Region: sopT; TIGR00339
59920000837	ATP-sulfurylase; Region: ATPS; cd00517
59920000838	active site
59920000839	HXXH motif; other site
59920000840	flexible loop; other site
59920000841	Manganese-stabilising protein / photosystem II polypeptide; Region: MSP; cl03326
59920000842	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
59920000843	Flavoprotein; Region: Flavoprotein; pfam02441
59920000844	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
59920000845	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
59920000846	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
59920000847	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
59920000848	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
59920000849	active site
59920000850	DNA binding site [nucleotide binding]
59920000851	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
59920000852	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
59920000853	Beta-carotene hydroxylase (CrtR), the carotenoid zeaxanthin biosynthetic enzyme catalyzes the addition of hydroxyl groups to the beta-ionone rings of beta-carotene to form zeaxanthin and is found in bacteria and red algae. Carotenoids are important...; Region: CrtR_beta-carotene-hydroxylase; cd03514
59920000854	putative di-iron ligands [ion binding]; other site
59920000855	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
59920000856	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
59920000857	active site
59920000858	HIGH motif; other site
59920000859	nucleotide binding site [chemical binding]; other site
59920000860	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
59920000861	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
59920000862	active site
59920000863	KMSKS motif; other site
59920000864	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
59920000865	tRNA binding surface [nucleotide binding]; other site
59920000866	anticodon binding site; other site
59920000867	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
59920000868	Protein of unknown function (DUF3177); Region: DUF3177; pfam11375
59920000869	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
59920000870	S-adenosylmethionine binding site [chemical binding]; other site
59920000871	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
59920000872	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
59920000873	FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847
59920000874	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
59920000875	trimer interface [polypeptide binding]; other site
59920000876	active site
59920000877	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; cl17276
59920000878	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
59920000879	global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697
59920000880	ligand binding site [chemical binding]; other site
59920000881	flexible hinge region; other site
59920000882	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
59920000883	putative switch regulator; other site
59920000884	non-specific DNA interactions [nucleotide binding]; other site
59920000885	DNA binding site [nucleotide binding]
59920000886	sequence specific DNA binding site [nucleotide binding]; other site
59920000887	putative cAMP binding site [chemical binding]; other site
59920000888	Protein of unknown function (DUF3084); Region: DUF3084; pfam11283
59920000889	Uncharacterized protein family (UPF0081); Region: UPF0081; cl17278
59920000890	Protein of unknown function (DUF3146); Region: DUF3146; pfam11344
59920000891	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
59920000892	putative active site [active]
59920000893	catalytic residue [active]
59920000894	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
59920000895	photosystem II reaction center protein H; Provisional; Region: psbH; PRK02624
59920000896	photosystem II reaction center I protein I; Provisional; Region: psbI; PRK02655
59920000897	Protein of unknown function (DUF3769); Region: DUF3769; pfam12600
59920000898	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
59920000899	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
59920000900	substrate binding site [chemical binding]; other site
59920000901	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
59920000902	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
59920000903	substrate binding site [chemical binding]; other site
59920000904	ligand binding site [chemical binding]; other site
59920000905	competence damage-inducible protein A; Provisional; Region: PRK00549
59920000906	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
59920000907	putative MPT binding site; other site
59920000908	Competence-damaged protein; Region: CinA; pfam02464
59920000909	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
59920000910	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
59920000911	dimer interface [polypeptide binding]; other site
59920000912	active site
59920000913	glycine-pyridoxal phosphate binding site [chemical binding]; other site
59920000914	folate binding site [chemical binding]; other site
59920000915	Protein of unknown function (DUF3181); Region: DUF3181; pfam11378
59920000916	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
59920000917	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
59920000918	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
59920000919	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
59920000920	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Provisional; Region: PRK13371
59920000921	(E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216
59920000922	DoxX; Region: DoxX; pfam07681
59920000923	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
59920000924	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
59920000925	purine monophosphate binding site [chemical binding]; other site
59920000926	dimer interface [polypeptide binding]; other site
59920000927	putative catalytic residues [active]
59920000928	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
59920000929	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
59920000930	putative hydrolase; Provisional; Region: PRK11460
59920000931	Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230
59920000932	Protein of unknown function (DUF3155); Region: DUF3155; pfam11352
59920000933	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
59920000934	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
59920000935	dimer interface [polypeptide binding]; other site
59920000936	phosphorylation site [posttranslational modification]
59920000937	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
59920000938	ATP binding site [chemical binding]; other site
59920000939	Mg2+ binding site [ion binding]; other site
59920000940	G-X-G motif; other site
59920000941	cobalamin synthase; Reviewed; Region: cobS; PRK00235
59920000942	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
59920000943	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
59920000944	Photosystem II 4 kDa reaction centre component; Region: PsbK; cl03641
59920000945	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
59920000946	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
59920000947	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
59920000948	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
59920000949	Domain of unknown function DUF21; Region: DUF21; pfam01595
59920000950	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
59920000951	Transporter associated domain; Region: CorC_HlyC; smart01091
59920000952	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
59920000953	active site
59920000954	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
59920000955	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
59920000956	RecB family nuclease, putative, TM0106 family; Region: TIGR03491
59920000957	RNase_H superfamily; Region: RNase_H_2; pfam13482
59920000958	The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757
59920000959	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
59920000960	active site
59920000961	substrate binding site [chemical binding]; other site
59920000962	metal binding site [ion binding]; metal-binding site
59920000963	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
59920000964	active site
59920000965	dimerization interface [polypeptide binding]; other site
59920000966	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
59920000967	Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055
59920000968	imidazoleglycerol-phosphate dehydratase; Region: PLN02800
59920000969	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
59920000970	putative active site pocket [active]
59920000971	4-fold oligomerization interface [polypeptide binding]; other site
59920000972	metal binding residues [ion binding]; metal-binding site
59920000973	3-fold/trimer interface [polypeptide binding]; other site
59920000974	enoyl-(acyl carrier protein) reductase; Validated; Region: PRK07370
59920000975	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
59920000976	NAD binding site [chemical binding]; other site
59920000977	homotetramer interface [polypeptide binding]; other site
59920000978	homodimer interface [polypeptide binding]; other site
59920000979	substrate binding site [chemical binding]; other site
59920000980	active site
59920000981	Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969
59920000982	putative catalytic residue [active]
59920000983	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
59920000984	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
59920000985	inhibitor-cofactor binding pocket; inhibition site
59920000986	pyridoxal 5'-phosphate binding site [chemical binding]; other site
59920000987	catalytic residue [active]
59920000988	DNA photolyase; Region: DNA_photolyase; pfam00875
59920000989	deoxyribodipyrimidine photo-lyase, 8-HDF type; Region: photolyase_8HDF; TIGR03556
59920000990	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
59920000991	dimer interface [polypeptide binding]; other site
59920000992	ADP-ribose binding site [chemical binding]; other site
59920000993	active site
59920000994	nudix motif; other site
59920000995	metal binding site [ion binding]; metal-binding site
59920000996	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
59920000997	catalytic center binding site [active]
59920000998	ATP binding site [chemical binding]; other site
59920000999	magnesium chelatase ATPase subunit I; Region: BchI-ChlI; TIGR02030
59920001000	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
59920001001	Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451
59920001002	metal ion-dependent adhesion site (MIDAS); other site
59920001003	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
59920001004	mce related protein; Region: MCE; pfam02470
59920001005	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
59920001006	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
59920001007	Walker A/P-loop; other site
59920001008	ATP binding site [chemical binding]; other site
59920001009	Q-loop/lid; other site
59920001010	ABC transporter signature motif; other site
59920001011	Walker B; other site
59920001012	D-loop; other site
59920001013	H-loop/switch region; other site
59920001014	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
59920001015	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
59920001016	phosphate binding site [ion binding]; other site
59920001017	putative substrate binding pocket [chemical binding]; other site
59920001018	dimer interface [polypeptide binding]; other site
59920001019	NADH dehydrogenase subunit J; Provisional; Region: PRK12494
59920001020	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917
59920001021	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194
59920001022	NADH dehydrogenase subunit 3; Region: ndhC; CHL00022
59920001023	Rubredoxin [Energy production and conversion]; Region: COG1773
59920001024	Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202
59920001025	iron binding site [ion binding]; other site
59920001026	Ycf48-like protein; Provisional; Region: PRK13684
59920001027	cytochrome b559 subunit alpha; Provisional; Region: psbE; PRK02557
59920001028	Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits; Region: Cytochrom_B559; pfam00283
59920001029	Lumenal portion of Cytochrome b559, alpha (gene psbE) subunit; Region: Cytochrom_B559a; pfam00284
59920001030	photosystem II reaction center L; Provisional; Region: psbL; PRK00753
59920001031	photosystem II reaction center protein J; Provisional; Region: PRK02565
59920001032	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
59920001033	pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169
59920001034	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
59920001035	dimerization interface [polypeptide binding]; other site
59920001036	putative ATP binding site [chemical binding]; other site
59920001037	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
59920001038	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
59920001039	active site
59920001040	NTP binding site [chemical binding]; other site
59920001041	metal binding triad [ion binding]; metal-binding site
59920001042	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
59920001043	Part of AAA domain; Region: AAA_19; pfam13245
59920001044	Family description; Region: UvrD_C_2; pfam13538
59920001045	Phycobilisome protein; Region: Phycobilisome; cl08227
59920001046	Phycobilisome protein; Region: Phycobilisome; cl08227
59920001047	HEAT repeats; Region: HEAT_2; pfam13646
59920001048	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
59920001049	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
59920001050	CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206
59920001051	CpeS-like protein; Region: CpeS; pfam09367
59920001052	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
59920001053	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
59920001054	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
59920001055	UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230
59920001056	NAD binding site [chemical binding]; other site
59920001057	putative substrate binding site 2 [chemical binding]; other site
59920001058	putative substrate binding site 1 [chemical binding]; other site
59920001059	active site
59920001060	UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253
59920001061	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
59920001062	putative NAD(P) binding site [chemical binding]; other site
59920001063	active site
59920001064	putative substrate binding site [chemical binding]; other site
59920001065	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
59920001066	Tetratricopeptide repeat; Region: TPR_12; pfam13424
59920001067	binding surface
59920001068	TPR motif; other site
59920001069	TPR repeat; Region: TPR_11; pfam13414
59920001070	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
59920001071	binding surface
59920001072	TPR motif; other site
59920001073	TPR repeat; Region: TPR_11; pfam13414
59920001074	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
59920001075	binding surface
59920001076	TPR motif; other site
59920001077	TPR repeat; Region: TPR_11; pfam13414
59920001078	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
59920001079	Protein of unknown function (DUF2470); Region: DUF2470; pfam10615
59920001080	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
59920001081	D-xylulose kinase; Region: XylB; TIGR01312
59920001082	nucleotide binding site [chemical binding]; other site
59920001083	S-adenosylmethionine synthetase; Validated; Region: PRK05250
59920001084	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
59920001085	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
59920001086	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
59920001087	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
59920001088	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
59920001089	active site
59920001090	motif I; other site
59920001091	motif II; other site
59920001092	30S ribosomal protein S1; Reviewed; Region: PRK07400
59920001093	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
59920001094	RNA binding site [nucleotide binding]; other site
59920001095	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
59920001096	RNA binding site [nucleotide binding]; other site
59920001097	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
59920001098	RNA binding site [nucleotide binding]; other site
59920001099	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
59920001100	ATP cone domain; Region: ATP-cone; pfam03477
59920001101	photosystem II reaction center protein T; Reviewed; Region: psbT; PRK11875
59920001102	photosystem II chlorophyll-binding protein CP47; Region: PS_II_CP47; TIGR03039
59920001103	photosystem II reaction center protein M; Provisional; Region: psbM; PRK14094
59920001104	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
59920001105	active site
59920001106	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
59920001107	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
59920001108	S-adenosylmethionine binding site [chemical binding]; other site
59920001109	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
59920001110	cell division topological specificity factor MinE; Provisional; Region: PRK13988
59920001111	septum site-determining protein MinD; Region: minD_bact; TIGR01968
59920001112	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
59920001113	P-loop; other site
59920001114	ADP binding residues [chemical binding]; other site
59920001115	Switch I; other site
59920001116	Switch II; other site
59920001117	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
59920001118	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
59920001119	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471
59920001120	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
59920001121	C-terminal peptidase (prc); Region: prc; TIGR00225
59920001122	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
59920001123	protein binding site [polypeptide binding]; other site
59920001124	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
59920001125	Catalytic dyad [active]
59920001126	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
59920001127	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
59920001128	Qi binding site; other site
59920001129	intrachain domain interface; other site
59920001130	interchain domain interface [polypeptide binding]; other site
59920001131	heme bH binding site [chemical binding]; other site
59920001132	heme bL binding site [chemical binding]; other site
59920001133	Qo binding site; other site
59920001134	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
59920001135	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290
59920001136	interchain domain interface [polypeptide binding]; other site
59920001137	intrachain domain interface; other site
59920001138	Qi binding site; other site
59920001139	Qo binding site; other site
59920001140	Alkaline and neutral invertase; Region: Glyco_hydro_100; pfam12899
59920001141	formamidopyrimidine-DNA glycosylase; Provisional; Region: PRK13945
59920001142	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
59920001143	DNA binding site [nucleotide binding]
59920001144	catalytic residue [active]
59920001145	H2TH interface [polypeptide binding]; other site
59920001146	putative catalytic residues [active]
59920001147	turnover-facilitating residue; other site
59920001148	intercalation triad [nucleotide binding]; other site
59920001149	8OG recognition residue [nucleotide binding]; other site
59920001150	putative reading head residues; other site
59920001151	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
59920001152	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
59920001153	photosystem I reaction center subunit IV; Provisional; Region: PRK02749
59920001154	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
59920001155	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
59920001156	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
59920001157	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
59920001158	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
59920001159	ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087
59920001160	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
59920001161	NAD(P) binding site [chemical binding]; other site
59920001162	catalytic residues [active]
59920001163	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
59920001164	Protein of unknown function (DUF1651); Region: DUF1651; pfam07864
59920001165	Protein of unknown function (DUF3804); Region: DUF3804; pfam12707
59920001166	putative high light inducible protein; Region: PHA02337
59920001167	putative high light inducible protein; Region: PHA02337
59920001168	putative high light inducible protein; Region: PHA02337
59920001169	putative high light inducible protein; Region: PHA02337
59920001170	putative high light inducible protein; Region: PHA02337
59920001171	TPR repeat; Region: TPR_11; pfam13414
59920001172	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
59920001173	binding surface
59920001174	TPR motif; other site
59920001175	TPR repeat; Region: TPR_11; pfam13414
59920001176	TPR repeat; Region: TPR_11; pfam13414
59920001177	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
59920001178	binding surface
59920001179	TPR motif; other site
59920001180	TPR repeat; Region: TPR_11; pfam13414
59920001181	Tetratricopeptide repeat; Region: TPR_16; pfam13432
59920001182	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
59920001183	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
59920001184	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
59920001185	Dehydroquinase class II; Region: DHquinase_II; pfam01220
59920001186	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
59920001187	trimer interface [polypeptide binding]; other site
59920001188	active site
59920001189	dimer interface [polypeptide binding]; other site
59920001190	MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910
59920001191	active site
59920001192	dinuclear metal binding site [ion binding]; other site
59920001193	dimerization interface [polypeptide binding]; other site
59920001194	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
59920001195	active site
59920001196	SAM binding site [chemical binding]; other site
59920001197	homodimer interface [polypeptide binding]; other site
59920001198	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
59920001199	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
59920001200	FMN binding site [chemical binding]; other site
59920001201	active site
59920001202	catalytic residues [active]
59920001203	substrate binding site [chemical binding]; other site
59920001204	GTP-binding protein Der; Reviewed; Region: PRK00093
59920001205	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
59920001206	G1 box; other site
59920001207	GTP/Mg2+ binding site [chemical binding]; other site
59920001208	Switch I region; other site
59920001209	G2 box; other site
59920001210	Switch II region; other site
59920001211	G3 box; other site
59920001212	G4 box; other site
59920001213	G5 box; other site
59920001214	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
59920001215	G1 box; other site
59920001216	GTP/Mg2+ binding site [chemical binding]; other site
59920001217	Switch I region; other site
59920001218	G2 box; other site
59920001219	G3 box; other site
59920001220	Switch II region; other site
59920001221	G4 box; other site
59920001222	G5 box; other site
59920001223	Cobalt transport protein; Region: CbiQ; cl00463
59920001224	Protein of unknown function (DUF3539); Region: DUF3539; pfam12058
59920001225	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
59920001226	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
59920001227	catalytic residue [active]
59920001228	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799
59920001229	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
59920001230	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
59920001231	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
59920001232	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
59920001233	Recombination protein O N terminal; Region: RecO_N; pfam11967
59920001234	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
59920001235	Recombination protein O C terminal; Region: RecO_C; pfam02565
59920001236	Class I aldolases; Region: Aldolase_Class_I; cl17187
59920001237	catalytic residue [active]
59920001238	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
59920001239	30S subunit binding site; other site
59920001240	lipoate-protein ligase B; Provisional; Region: PRK14344
59920001241	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
59920001242	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
59920001243	acyl-activating enzyme (AAE) consensus motif; other site
59920001244	putative AMP binding site [chemical binding]; other site
59920001245	putative active site [active]
59920001246	putative CoA binding site [chemical binding]; other site
59920001247	Protein of unknown function (DUF2869); Region: DUF2869; pfam11068
59920001248	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
59920001249	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
59920001250	E3 interaction surface; other site
59920001251	lipoyl attachment site [posttranslational modification]; other site
59920001252	e3 binding domain; Region: E3_binding; pfam02817
59920001253	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
59920001254	Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547
59920001255	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
59920001256	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
59920001257	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
59920001258	dimer interface [polypeptide binding]; other site
59920001259	pyridoxal 5'-phosphate binding site [chemical binding]; other site
59920001260	catalytic residue [active]
59920001261	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
59920001262	Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626
59920001263	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
59920001264	catalytic residue [active]
59920001265	Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053
59920001266	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
59920001267	homodimer interface [polypeptide binding]; other site
59920001268	substrate-cofactor binding pocket; other site
59920001269	pyridoxal 5'-phosphate binding site [chemical binding]; other site
59920001270	catalytic residue [active]
59920001271	ribosomal protein S4; Reviewed; Region: rps4; CHL00113
59920001272	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
59920001273	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
59920001274	RNA binding surface [nucleotide binding]; other site
59920001275	Haemolytic domain; Region: Haemolytic; pfam01809
59920001276	Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
59920001277	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
59920001278	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
59920001279	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
59920001280	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
59920001281	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
59920001282	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
59920001283	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
59920001284	catalytic residue [active]
59920001285	Photosystem II reaction centre N protein (psbN); Region: PsbN; cl03605
59920001286	High-affinity nickel-transport protein; Region: NicO; cl00964
59920001287	NifU-like domain; Region: NifU; pfam01106
59920001288	malate:quinone oxidoreductase; Validated; Region: PRK05257
59920001289	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
59920001290	GTP-binding protein LepA; Provisional; Region: PRK05433
59920001291	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
59920001292	G1 box; other site
59920001293	putative GEF interaction site [polypeptide binding]; other site
59920001294	GTP/Mg2+ binding site [chemical binding]; other site
59920001295	Switch I region; other site
59920001296	G2 box; other site
59920001297	G3 box; other site
59920001298	Switch II region; other site
59920001299	G4 box; other site
59920001300	G5 box; other site
59920001301	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
59920001302	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
59920001303	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
59920001304	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
59920001305	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
59920001306	dimer interface [polypeptide binding]; other site
59920001307	conserved gate region; other site
59920001308	ABC-ATPase subunit interface; other site
59920001309	tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081
59920001310	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
59920001311	SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105
59920001312	16S rRNA methyltransferase B; Provisional; Region: PRK14901
59920001313	putative RNA binding site [nucleotide binding]; other site
59920001314	NusB family; Region: NusB; pfam01029
59920001315	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
59920001316	S-adenosylmethionine binding site [chemical binding]; other site
59920001317	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
59920001318	UbiA prenyltransferase family; Region: UbiA; pfam01040
59920001319	Protein of unknown function (DUF2862); Region: DUF2862; pfam11061
59920001320	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
59920001321	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
59920001322	substrate binding site [chemical binding]; other site
59920001323	glutamase interaction surface [polypeptide binding]; other site
59920001324	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
59920001325	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
59920001326	S-adenosylmethionine binding site [chemical binding]; other site
59920001327	Protein of unknown function (DUF721); Region: DUF721; pfam05258
59920001328	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
59920001329	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
59920001330	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
59920001331	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
59920001332	Walker A/P-loop; other site
59920001333	ATP binding site [chemical binding]; other site
59920001334	Q-loop/lid; other site
59920001335	ABC transporter signature motif; other site
59920001336	Walker B; other site
59920001337	D-loop; other site
59920001338	H-loop/switch region; other site
59920001339	NAD(P)H-quinone oxidoreductase subunit 2; Provisional; Region: PRK02504
59920001340	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
59920001341	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
59920001342	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
59920001343	active site
59920001344	interdomain interaction site; other site
59920001345	putative metal-binding site [ion binding]; other site
59920001346	nucleotide binding site [chemical binding]; other site
59920001347	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
59920001348	domain I; other site
59920001349	DNA binding groove [nucleotide binding]
59920001350	phosphate binding site [ion binding]; other site
59920001351	domain II; other site
59920001352	domain III; other site
59920001353	nucleotide binding site [chemical binding]; other site
59920001354	catalytic site [active]
59920001355	domain IV; other site
59920001356	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
59920001357	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
59920001358	Predicted membrane protein (DUF2232); Region: DUF2232; cl01728
59920001359	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
59920001360	putative dimer interface [polypeptide binding]; other site
59920001361	active site pocket [active]
59920001362	putative cataytic base [active]
59920001363	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
59920001364	Lumazine binding domain; Region: Lum_binding; pfam00677
59920001365	Lumazine binding domain; Region: Lum_binding; pfam00677
59920001366	AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250
59920001367	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386
59920001368	Subunit I/III interface [polypeptide binding]; other site
59920001369	cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891
59920001370	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
59920001371	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
59920001372	cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866
59920001373	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
59920001374	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
59920001375	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
59920001376	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
59920001377	UbiA prenyltransferase family; Region: UbiA; pfam01040
59920001378	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
59920001379	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
59920001380	Walker A/P-loop; other site
59920001381	ATP binding site [chemical binding]; other site
59920001382	Q-loop/lid; other site
59920001383	ABC transporter signature motif; other site
59920001384	Walker B; other site
59920001385	D-loop; other site
59920001386	H-loop/switch region; other site
59920001387	ABC-2 type transporter; Region: ABC2_membrane; cl17235
59920001388	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
59920001389	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
59920001390	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
59920001391	ring oligomerisation interface [polypeptide binding]; other site
59920001392	ATP/Mg binding site [chemical binding]; other site
59920001393	stacking interactions; other site
59920001394	hinge regions; other site
59920001395	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
59920001396	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
59920001397	NAD(P) binding site [chemical binding]; other site
59920001398	homotetramer interface [polypeptide binding]; other site
59920001399	homodimer interface [polypeptide binding]; other site
59920001400	active site
59920001401	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
59920001402	substrate binding site; other site
59920001403	dimer interface; other site
59920001404	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
59920001405	dimer interface [polypeptide binding]; other site
59920001406	catalytic triad [active]
59920001407	prenyltransferase; Reviewed; Region: ubiA; PRK12873
59920001408	UbiA prenyltransferase family; Region: UbiA; pfam01040
59920001409	exopolyphosphatase; Region: exo_poly_only; TIGR03706
59920001410	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
59920001411	Helix-turn-helix domain; Region: HTH_25; pfam13413
59920001412	non-specific DNA binding site [nucleotide binding]; other site
59920001413	salt bridge; other site
59920001414	sequence-specific DNA binding site [nucleotide binding]; other site
59920001415	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
59920001416	active site
59920001417	SAM binding site [chemical binding]; other site
59920001418	homodimer interface [polypeptide binding]; other site
59920001419	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
59920001420	cytochrome f; Region: petA; CHL00037
59920001421	apocytochrome f; Reviewed; Region: PRK02693
59920001422	cytochrome b6-f complex iron-sulfur subunit; Provisional; Region: PRK13474
59920001423	Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802
59920001424	Iron-sulfur protein (ISP) component of the b6f complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The cytochrome b6f complex from Mastigocladus laminosus, a thermophilic cyanobacterium; Region: Rieske_cytochrome_b6f; cd03471
59920001425	cytochrome b subunit interaction site [polypeptide binding]; other site
59920001426	[2Fe-2S] cluster binding site [ion binding]; other site
59920001427	Protein of unknown function (DUF3067); Region: DUF3067; pfam11267
59920001428	Sec-independent translocase component C; Provisional; Region: tatC; CHL00182
59920001429	Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833
59920001430	Domain of unknown function (DUF814); Region: DUF814; pfam05670
59920001431	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
59920001432	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
59920001433	catalytic site [active]
59920001434	G-X2-G-X-G-K; other site
59920001435	photosystem I reaction center subunit IX; Provisional; Region: PRK02733
59920001436	Photosystem I reaction centre subunit III; Region: PSI_PsaF; cl03627
59920001437	tRNA threonylcarbamoyl adenosine modification protein YgjD; Region: T6A_YgjD; TIGR03723
59920001438	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
59920001439	Protein of unknown function (DUF1643); Region: DUF1643; pfam07799
59920001440	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
59920001441	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
59920001442	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
59920001443	HIGH motif; other site
59920001444	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
59920001445	active site
59920001446	KMSKS motif; other site
59920001447	Src Homology 3 domain superfamily; Region: SH3; cl17036
59920001448	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
59920001449	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
59920001450	active site
59920001451	short chain dehydrogenase; Provisional; Region: PRK12367
59920001452	NAD(P) binding site [chemical binding]; other site
59920001453	BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857
59920001454	DRTGG domain; Region: DRTGG; pfam07085
59920001455	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
59920001456	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
59920001457	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
59920001458	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
59920001459	SPFH domain / Band 7 family; Region: Band_7; pfam01145
59920001460	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
59920001461	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
59920001462	inhibitor-cofactor binding pocket; inhibition site
59920001463	pyridoxal 5'-phosphate binding site [chemical binding]; other site
59920001464	catalytic residue [active]
59920001465	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
59920001466	putative catalytic site [active]
59920001467	putative phosphate binding site [ion binding]; other site
59920001468	active site
59920001469	metal binding site A [ion binding]; metal-binding site
59920001470	DNA binding site [nucleotide binding]
59920001471	putative AP binding site [nucleotide binding]; other site
59920001472	putative metal binding site B [ion binding]; other site
59920001473	hypothetical protein; Provisional; Region: PRK04194
59920001474	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
59920001475	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
59920001476	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
59920001477	dimer interface [polypeptide binding]; other site
59920001478	conserved gate region; other site
59920001479	putative PBP binding loops; other site
59920001480	ABC-ATPase subunit interface; other site
59920001481	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
59920001482	dimer interface [polypeptide binding]; other site
59920001483	conserved gate region; other site
59920001484	putative PBP binding loops; other site
59920001485	ABC-ATPase subunit interface; other site
59920001486	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
59920001487	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
59920001488	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
59920001489	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914
59920001490	aromatic arch; other site
59920001491	DCoH dimer interaction site [polypeptide binding]; other site
59920001492	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
59920001493	DCoH tetramer interaction site [polypeptide binding]; other site
59920001494	substrate binding site [chemical binding]; other site
59920001495	Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894
59920001496	Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317
59920001497	Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460
59920001498	active site
59920001499	Zn binding site [ion binding]; other site
59920001500	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
59920001501	dimer interface [polypeptide binding]; other site
59920001502	substrate binding site [chemical binding]; other site
59920001503	metal binding sites [ion binding]; metal-binding site
59920001504	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
59920001505	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
59920001506	domain interfaces; other site
59920001507	active site
59920001508	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
59920001509	RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997
59920001510	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
59920001511	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
59920001512	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
59920001513	DNA binding residues [nucleotide binding]
59920001514	primosome assembly protein PriA; Validated; Region: PRK05580
59920001515	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
59920001516	ATP binding site [chemical binding]; other site
59920001517	putative Mg++ binding site [ion binding]; other site
59920001518	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
59920001519	ATP-binding site [chemical binding]; other site
59920001520	Protein of unknown function (DUF3153); Region: DUF3153; pfam11353
59920001521	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
59920001522	feedback inhibition sensing region; other site
59920001523	homohexameric interface [polypeptide binding]; other site
59920001524	nucleotide binding site [chemical binding]; other site
59920001525	N-acetyl-L-glutamate binding site [chemical binding]; other site
59920001526	Protein of unknown function (DUF2854); Region: DUF2854; pfam11016
59920001527	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
59920001528	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
59920001529	ssDNA binding site [nucleotide binding]; other site
59920001530	dimer interface [polypeptide binding]; other site
59920001531	tetramer (dimer of dimers) interface [polypeptide binding]; other site
59920001532	Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571
59920001533	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
59920001534	Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324
59920001535	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
59920001536	Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168
59920001537	substrate binding site [chemical binding]; other site
59920001538	ATP binding site [chemical binding]; other site
59920001539	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
59920001540	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
59920001541	GDP-binding site [chemical binding]; other site
59920001542	ACT binding site; other site
59920001543	IMP binding site; other site
59920001544	photosystem II protein Psb27; Region: PS_II_psb27; TIGR03044
59920001545	prolyl-tRNA synthetase; Provisional; Region: PRK09194
59920001546	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
59920001547	motif 1; other site
59920001548	dimer interface [polypeptide binding]; other site
59920001549	active site
59920001550	motif 2; other site
59920001551	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
59920001552	putative deacylase active site [active]
59920001553	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
59920001554	active site
59920001555	motif 3; other site
59920001556	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
59920001557	anticodon binding site; other site
59920001558	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
59920001559	dimer interface [polypeptide binding]; other site
59920001560	substrate binding site [chemical binding]; other site
59920001561	metal binding sites [ion binding]; metal-binding site
59920001562	Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036
59920001563	ArsC family; Region: ArsC; pfam03960
59920001564	putative ArsC-like catalytic residues; other site
59920001565	putative TRX-like catalytic residues [active]
59920001566	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
59920001567	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
59920001568	Catalytic site [active]
59920001569	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
59920001570	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
59920001571	catalytic core [active]
59920001572	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
59920001573	catalytic core [active]
59920001574	CAAX protease self-immunity; Region: Abi; pfam02517
59920001575	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
59920001576	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
59920001577	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
59920001578	transaldolase-like protein; Provisional; Region: PTZ00411
59920001579	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
59920001580	active site
59920001581	dimer interface [polypeptide binding]; other site
59920001582	catalytic residue [active]
59920001583	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
59920001584	ribosome recycling factor; Reviewed; Region: frr; PRK00083
59920001585	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
59920001586	hinge region; other site
59920001587	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
59920001588	putative nucleotide binding site [chemical binding]; other site
59920001589	uridine monophosphate binding site [chemical binding]; other site
59920001590	homohexameric interface [polypeptide binding]; other site
59920001591	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; cl17276
59920001592	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
59920001593	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
59920001594	homodimer interface [polypeptide binding]; other site
59920001595	Walker A motif; other site
59920001596	ATP binding site [chemical binding]; other site
59920001597	hydroxycobalamin binding site [chemical binding]; other site
59920001598	Walker B motif; other site
59920001599	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
59920001600	active site
59920001601	catalytic residues [active]
59920001602	DNA binding site [nucleotide binding]
59920001603	Int/Topo IB signature motif; other site
59920001604	ferrochelatase; Reviewed; Region: hemH; PRK00035
59920001605	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
59920001606	C-terminal domain interface [polypeptide binding]; other site
59920001607	active site
59920001608	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
59920001609	active site
59920001610	N-terminal domain interface [polypeptide binding]; other site
59920001611	acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK07418
59920001612	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
59920001613	PYR/PP interface [polypeptide binding]; other site
59920001614	dimer interface [polypeptide binding]; other site
59920001615	TPP binding site [chemical binding]; other site
59920001616	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
59920001617	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
59920001618	TPP-binding site [chemical binding]; other site
59920001619	dimer interface [polypeptide binding]; other site
59920001620	Protein of unknown function (DUF1092); Region: DUF1092; pfam06485
59920001621	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
59920001622	RNA binding site [nucleotide binding]; other site
59920001623	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
59920001624	RNA binding site [nucleotide binding]; other site
59920001625	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
59920001626	RNA binding site [nucleotide binding]; other site
59920001627	Creatinine amidohydrolase; Region: Creatininase; pfam02633
59920001628	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
59920001629	dinuclear metal binding motif [ion binding]; other site
59920001630	acyl-ACP reductase; Provisional; Region: PRK14982
59920001631	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
59920001632	NAD(P) binding pocket [chemical binding]; other site
59920001633	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
59920001634	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
59920001635	short chain dehydrogenase; Provisional; Region: PRK07454
59920001636	classical (c) SDRs; Region: SDR_c; cd05233
59920001637	NAD(P) binding site [chemical binding]; other site
59920001638	active site
59920001639	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
59920001640	active site
59920001641	SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164
59920001642	active site
59920001643	Peptidase family M50; Region: Peptidase_M50; pfam02163
59920001644	putative substrate binding region [chemical binding]; other site
59920001645	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
59920001646	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
59920001647	protochlorophyllide oxidoreductase; Validated; Region: PRK07453
59920001648	light-dependent protochlorophyllide reductase; Region: LPOR; TIGR01289
59920001649	NAD(P) binding site [chemical binding]; other site
59920001650	active site
59920001651	protochlorophyllide reductase iron-sulfur ATP-binding protein; Provisional; Region: chlL; PRK13185
59920001652	This family of proteins contains bchL and chlL. Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. Three genes, bchL, bchN and bchB, are...; Region: Bchl_like; cd02032
59920001653	P-loop; other site
59920001654	light-independent protochlorophyllide reductase subunit N; Provisional; Region: PRK02842
59920001655	light-independent protochlorophyllide reductase, N subunit; Region: DPOR_bchN; TIGR01279
59920001656	light-independent protochlorophyllide reductase subunit B; Provisional; Region: PRK02910
59920001657	Pchlide_reductase_B: B protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_B; cd01981
59920001658	Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369
59920001659	Bacterial Micro-Compartment (BMC)-like domain 1 repeat 1; Region: BMC_like_1_repeat1; cd07051
59920001660	putative hexamer interface [polypeptide binding]; other site
59920001661	putative hexagonal pore; other site
59920001662	Bacterial Micro-Compartment (BMC)-like domain 1 repeat 2; Region: BMC_like_1_repeat2; cd07052
59920001663	putative hexamer interface [polypeptide binding]; other site
59920001664	putative hexagonal pore; other site
59920001665	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
59920001666	active site
59920001667	dimerization interface [polypeptide binding]; other site
59920001668	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
59920001669	Carboxysome Shell 1 (CsoS1); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CsoS1; cd07058
59920001670	Hexamer interface [polypeptide binding]; other site
59920001671	Hexagonal pore residue; other site
59920001672	Hexagonal pore; other site
59920001673	ribulose bisophosphate carboxylase; Reviewed; Region: rbcL; PRK04208
59920001674	Ribulose bisphosphate carboxylase large chain; Region: RuBisCO_large; cl08232
59920001675	dimer interface [polypeptide binding]; other site
59920001676	catalytic residue [active]
59920001677	metal binding site [ion binding]; metal-binding site
59920001678	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527
59920001679	multimerization interface [polypeptide binding]; other site
59920001680	Carboxysome shell peptide mid-region; Region: CsoS2_M; pfam12288
59920001681	Carboxysome shell peptide mid-region; Region: CsoS2_M; pfam12288
59920001682	Carboxysome Shell Carbonic Anhydrase; Region: CsoSCA; pfam08936
59920001683	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
59920001684	Hexamer/Pentamer interface [polypeptide binding]; other site
59920001685	central pore; other site
59920001686	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
59920001687	Hexamer/Pentamer interface [polypeptide binding]; other site
59920001688	central pore; other site
59920001689	Carboxysome Shell 1 (CsoS1); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CsoS1; cd07058
59920001690	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
59920001691	Hexamer interface [polypeptide binding]; other site
59920001692	Hexagonal pore residue; other site
59920001693	Hexagonal pore; other site
59920001694	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cl00942
59920001695	DCoH dimer interaction site [polypeptide binding]; other site
59920001696	aromatic arch; other site
59920001697	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
59920001698	DCoH tetramer interaction site [polypeptide binding]; other site
59920001699	substrate binding site [chemical binding]; other site
59920001700	Protein of unknown function (DUF3136); Region: DUF3136; pfam11334
59920001701	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
59920001702	homotrimer interaction site [polypeptide binding]; other site
59920001703	putative active site [active]
59920001704	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
59920001705	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
59920001706	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
59920001707	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
59920001708	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
59920001709	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
59920001710	Walker A/P-loop; other site
59920001711	ATP binding site [chemical binding]; other site
59920001712	Q-loop/lid; other site
59920001713	ABC transporter signature motif; other site
59920001714	Walker B; other site
59920001715	D-loop; other site
59920001716	H-loop/switch region; other site
59920001717	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
59920001718	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
59920001719	Coenzyme A binding pocket [chemical binding]; other site
59920001720	GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522
59920001721	transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283
59920001722	Probable Catalytic site; other site
59920001723	transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282
59920001724	DnaA N-terminal domain; Region: DnaA_N; pfam11638
59920001725	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
59920001726	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
59920001727	Walker A motif; other site
59920001728	ATP binding site [chemical binding]; other site
59920001729	Walker B motif; other site
59920001730	arginine finger; other site
59920001731	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
59920001732	DnaA box-binding interface [nucleotide binding]; other site
59920001733	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
59920001734	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
59920001735	C-terminal domain interface [polypeptide binding]; other site
59920001736	GSH binding site (G-site) [chemical binding]; other site
59920001737	dimer interface [polypeptide binding]; other site
59920001738	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
59920001739	N-terminal domain interface [polypeptide binding]; other site
59920001740	dimer interface [polypeptide binding]; other site
59920001741	substrate binding pocket (H-site) [chemical binding]; other site
59920001742	glutathione reductase; Validated; Region: PRK06116
59920001743	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
59920001744	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
59920001745	K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367
59920001746	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
59920001747	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
59920001748	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
59920001749	active site
59920001750	substrate binding pocket [chemical binding]; other site
59920001751	dimer interface [polypeptide binding]; other site
59920001752	S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304
59920001753	NADH dehydrogenase transmembrane subunit; Region: NdhL; pfam10716
59920001754	Protein of unknown function (DUF3007); Region: DUF3007; pfam11460
59920001755	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
59920001756	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
59920001757	substrate binding site [chemical binding]; other site
59920001758	active site
59920001759	catalytic residues [active]
59920001760	heterodimer interface [polypeptide binding]; other site
59920001761	YciI-like protein; Reviewed; Region: PRK12864
59920001762	Cytochrome c; Region: Cytochrom_C; cl11414
59920001763	Uncharacterized conserved protein [Function unknown]; Region: COG3339
59920001764	RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997
59920001765	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
59920001766	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
59920001767	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
59920001768	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
59920001769	DNA binding residues [nucleotide binding]
59920001770	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
59920001771	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
59920001772	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
59920001773	metal binding site [ion binding]; metal-binding site
59920001774	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
59920001775	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
59920001776	Clp amino terminal domain; Region: Clp_N; pfam02861
59920001777	Clp amino terminal domain; Region: Clp_N; pfam02861
59920001778	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
59920001779	Walker A motif; other site
59920001780	ATP binding site [chemical binding]; other site
59920001781	Walker B motif; other site
59920001782	arginine finger; other site
59920001783	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
59920001784	Walker A motif; other site
59920001785	ATP binding site [chemical binding]; other site
59920001786	Walker B motif; other site
59920001787	arginine finger; other site
59920001788	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
59920001789	plastocyanin; Provisional; Region: PRK02710
59920001790	Plastocyanin [Energy production and conversion]; Region: PetE; COG3794
59920001791	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
59920001792	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
59920001793	NAD(P) binding site [chemical binding]; other site
59920001794	active site
59920001795	methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252
59920001796	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
59920001797	substrate binding site [chemical binding]; other site
59920001798	active site
59920001799	glycogen branching enzyme; Provisional; Region: PRK05402
59920001800	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
59920001801	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
59920001802	active site
59920001803	catalytic site [active]
59920001804	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
59920001805	Predicted acyl esterases [General function prediction only]; Region: COG2936
59920001806	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
59920001807	Domain of unknown function (DUF4332); Region: DUF4332; pfam14229
59920001808	Protein of function (DUF2518); Region: DUF2518; pfam10726
59920001809	Family of unknown function (DUF490); Region: DUF490; pfam04357
59920001810	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
59920001811	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
59920001812	putative catalytic cysteine [active]
59920001813	Dihydroneopterin aldolase; Region: FolB; smart00905
59920001814	active site
59920001815	Lipase (class 2); Region: Lipase_2; pfam01674
59920001816	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
59920001817	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
59920001818	active site
59920001819	Zn binding site [ion binding]; other site
59920001820	NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK12561
59920001821	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
59920001822	homoserine kinase; Provisional; Region: PRK01212
59920001823	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
59920001824	Glucokinase; Region: Glucokinase; pfam02685
59920001825	glucokinase, proteobacterial type; Region: glk; TIGR00749
59920001826	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
59920001827	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
59920001828	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
59920001829	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
59920001830	active site
59920001831	dimer interface [polypeptide binding]; other site
59920001832	motif 1; other site
59920001833	motif 2; other site
59920001834	motif 3; other site
59920001835	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
59920001836	anticodon binding site; other site
59920001837	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
59920001838	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
59920001839	active site
59920001840	HIGH motif; other site
59920001841	dimer interface [polypeptide binding]; other site
59920001842	KMSKS motif; other site
59920001843	Domain of unknown function (DUF697); Region: DUF697; pfam05128
59920001844	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
59920001845	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
59920001846	metal binding site [ion binding]; metal-binding site
59920001847	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
59920001848	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
59920001849	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
59920001850	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
59920001851	ABC-ATPase subunit  interface; other site
59920001852	dimer interface [polypeptide binding]; other site
59920001853	putative PBP binding regions; other site
59920001854	Domain of unknown function (DUF4336); Region: DUF4336; pfam14234
59920001855	Protein of unknown function (DUF760); Region: DUF760; pfam05542
59920001856	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
59920001857	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
59920001858	Catalytic site [active]
59920001859	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase; Region: menD; TIGR00173
59920001860	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
59920001861	dimer interface [polypeptide binding]; other site
59920001862	tetramer interface [polypeptide binding]; other site
59920001863	PYR/PP interface [polypeptide binding]; other site
59920001864	TPP binding site [chemical binding]; other site
59920001865	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
59920001866	TPP-binding site; other site
59920001867	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
59920001868	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
59920001869	substrate binding site [chemical binding]; other site
59920001870	oxyanion hole (OAH) forming residues; other site
59920001871	trimer interface [polypeptide binding]; other site
59920001872	glycogen synthase; Provisional; Region: glgA; PRK00654
59920001873	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
59920001874	ADP-binding pocket [chemical binding]; other site
59920001875	homodimer interface [polypeptide binding]; other site
59920001876	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
59920001877	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143
59920001878	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
59920001879	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14360
59920001880	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
59920001881	Substrate binding site; other site
59920001882	Mg++ binding site; other site
59920001883	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
59920001884	active site
59920001885	substrate binding site [chemical binding]; other site
59920001886	CoA binding site [chemical binding]; other site
59920001887	S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; cl17711
59920001888	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
59920001889	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
59920001890	hinge; other site
59920001891	active site
59920001892	3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043
59920001893	2-phosphosulfolactate phosphatase; Provisional; Region: PRK00886
59920001894	Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045
59920001895	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
59920001896	nitrilase; Region: PLN02798
59920001897	putative active site [active]
59920001898	catalytic triad [active]
59920001899	dimer interface [polypeptide binding]; other site
59920001900	AMIN domain; Region: AMIN; pfam11741
59920001901	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
59920001902	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
59920001903	active site
59920001904	metal binding site [ion binding]; metal-binding site
59920001905	glutamate racemase; Provisional; Region: PRK00865
59920001906	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
59920001907	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
59920001908	substrate binding pocket [chemical binding]; other site
59920001909	chain length determination region; other site
59920001910	substrate-Mg2+ binding site; other site
59920001911	catalytic residues [active]
59920001912	aspartate-rich region 1; other site
59920001913	active site lid residues [active]
59920001914	aspartate-rich region 2; other site
59920001915	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
59920001916	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
59920001917	active site
59920001918	motif I; other site
59920001919	motif II; other site
59920001920	acetyl-CoA synthetase; Provisional; Region: PRK00174
59920001921	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
59920001922	active site
59920001923	CoA binding site [chemical binding]; other site
59920001924	acyl-activating enzyme (AAE) consensus motif; other site
59920001925	AMP binding site [chemical binding]; other site
59920001926	acetate binding site [chemical binding]; other site
59920001927	Protein of unknown function (DUF1350); Region: DUF1350; pfam07082
59920001928	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
59920001929	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
59920001930	active site
59920001931	catalytic site [active]
59920001932	substrate binding site [chemical binding]; other site
59920001933	histidyl-tRNA synthetase; Region: hisS; TIGR00442
59920001934	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
59920001935	dimer interface [polypeptide binding]; other site
59920001936	motif 1; other site
59920001937	active site
59920001938	motif 2; other site
59920001939	motif 3; other site
59920001940	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
59920001941	anticodon binding site; other site
59920001942	probable UDP-glucose 6-dehydrogenase; Region: PLN02353
59920001943	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
59920001944	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
59920001945	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
59920001946	Tryptophan-rich protein (DUF2389); Region: DUF2389; pfam09493
59920001947	Helix-turn-helix domain; Region: HTH_17; cl17695
59920001948	chlorophyll a/b binding light-harvesting protein; Region: PS_antenn_a_b; TIGR03041
59920001949	Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786
59920001950	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
59920001951	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
59920001952	C-terminal, alpha helical domain of an unknown subfamily 5 of Glutathione S-transferases; Region: GST_C_5; cd03196
59920001953	putative N-terminal domain interface [polypeptide binding]; other site
59920001954	putative dimer interface [polypeptide binding]; other site
59920001955	putative substrate binding pocket (H-site) [chemical binding]; other site
59920001956	This entry represents the putative helicase A859L; Region: T5orf172; smart00974
59920001957	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
59920001958	short chain dehydrogenase; Provisional; Region: PRK07326
59920001959	NAD(P) binding site [chemical binding]; other site
59920001960	active site
59920001961	lycopene cyclase family protein; Region: carotene-cycl; TIGR01790
59920001962	lycopene cyclase; Region: lycopene_cycl; TIGR01789
59920001963	light-dependent protochlorophyllide reductase; Region: LPOR; TIGR01289
59920001964	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
59920001965	NAD(P) binding site [chemical binding]; other site
59920001966	active site
59920001967	Mechanosensitive ion channel; Region: MS_channel; pfam00924
59920001968	Isochorismatase family; Region: Isochorismatase; pfam00857
59920001969	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
59920001970	catalytic triad [active]
59920001971	dimer interface [polypeptide binding]; other site
59920001972	conserved cis-peptide bond; other site
59920001973	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
59920001974	metal binding site 2 [ion binding]; metal-binding site
59920001975	putative DNA binding helix; other site
59920001976	metal binding site 1 [ion binding]; metal-binding site
59920001977	dimer interface [polypeptide binding]; other site
59920001978	structural Zn2+ binding site [ion binding]; other site
59920001979	radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167
59920001980	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
59920001981	FeS/SAM binding site; other site
59920001982	Protein of unknown function (DUF3641); Region: DUF3641; pfam12345
59920001983	glucosylglycerol 3-phosphatase; Region: salt_tol_Pase; TIGR02399
59920001984	Glucosylglycerol-phosphate phosphatase (Salt_tol_Pase); Region: Salt_tol_Pase; pfam09506
59920001985	Phosphotransferase enzyme family; Region: APH; pfam01636
59920001986	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
59920001987	substrate binding site [chemical binding]; other site
59920001988	OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326
59920001989	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
59920001990	homodimer interface [polypeptide binding]; other site
59920001991	substrate-cofactor binding pocket; other site
59920001992	pyridoxal 5'-phosphate binding site [chemical binding]; other site
59920001993	catalytic residue [active]
59920001994	Homoserine O-succinyltransferase; Region: HTS; pfam04204
59920001995	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
59920001996	proposed active site lysine [active]
59920001997	conserved cys residue [active]
59920001998	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
59920001999	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
59920002000	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
59920002001	putative active site [active]
59920002002	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
59920002003	putative active site [active]
59920002004	Protein of unknown function (DUF2811); Region: DUF2811; pfam10929
59920002005	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
59920002006	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
59920002007	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
59920002008	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
59920002009	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
59920002010	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
59920002011	Protein of unknown function (DUF1662); Region: DUF1662; pfam07878
59920002012	ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent; Region: RTPR; TIGR02505
59920002013	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
59920002014	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
59920002015	S-adenosylmethionine binding site [chemical binding]; other site
59920002016	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
59920002017	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
59920002018	G1 box; other site
59920002019	putative GEF interaction site [polypeptide binding]; other site
59920002020	GTP/Mg2+ binding site [chemical binding]; other site
59920002021	Switch I region; other site
59920002022	G2 box; other site
59920002023	G3 box; other site
59920002024	Switch II region; other site
59920002025	G4 box; other site
59920002026	G5 box; other site
59920002027	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
59920002028	Protein of unknown function (DUF3353); Region: DUF3353; pfam11833
59920002029	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
59920002030	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
59920002031	dimerization interface [polypeptide binding]; other site
59920002032	domain crossover interface; other site
59920002033	redox-dependent activation switch; other site
59920002034	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
59920002035	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
59920002036	Walker A/P-loop; other site
59920002037	ATP binding site [chemical binding]; other site
59920002038	Q-loop/lid; other site
59920002039	ABC transporter signature motif; other site
59920002040	Walker B; other site
59920002041	D-loop; other site
59920002042	H-loop/switch region; other site
59920002043	Protein of unknown function (DUF3531); Region: DUF3531; pfam12049
59920002044	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
59920002045	Integral membrane protein DUF92; Region: DUF92; pfam01940
59920002046	SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_3; cd01835
59920002047	active site
59920002048	catalytic triad [active]
59920002049	oxyanion hole [active]
59920002050	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
59920002051	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
59920002052	ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638
59920002053	Walker A/P-loop; other site
59920002054	ATP binding site [chemical binding]; other site
59920002055	Q-loop/lid; other site
59920002056	ABC transporter signature motif; other site
59920002057	Walker B; other site
59920002058	D-loop; other site
59920002059	H-loop/switch region; other site
59920002060	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
59920002061	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
59920002062	aspartate aminotransferase; Provisional; Region: PRK05764
59920002063	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
59920002064	pyridoxal 5'-phosphate binding site [chemical binding]; other site
59920002065	homodimer interface [polypeptide binding]; other site
59920002066	catalytic residue [active]
59920002067	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
59920002068	Fe-S cluster binding site [ion binding]; other site
59920002069	active site
59920002070	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
59920002071	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
59920002072	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
59920002073	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
59920002074	C-terminal peptidase (prc); Region: prc; TIGR00225
59920002075	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
59920002076	protein binding site [polypeptide binding]; other site
59920002077	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
59920002078	Catalytic dyad [active]
59920002079	Domain of Unknown Function (DUF1543); Region: DUF1543; pfam07566
59920002080	quinolinate synthetase; Provisional; Region: PRK09375
59920002081	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
59920002082	TIGR04168 family protein; Region: TIGR04168
59920002083	Repair protein; Region: Repair_PSII; pfam04536
59920002084	Uncharacterized conserved protein [Function unknown]; Region: COG1565
59920002085	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
59920002086	active site
59920002087	dimer interface [polypeptide binding]; other site
59920002088	metal binding site [ion binding]; metal-binding site
59920002089	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
59920002090	ATP-grasp domain; Region: ATP-grasp; pfam02222
59920002091	Domain of unknown function (DUF1824); Region: DUF1824; pfam08854
59920002092	Protein of unknown function (DUF1651); Region: DUF1651; pfam07864
59920002093	Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014
59920002094	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246
59920002095	Spondin_N; Region: Spond_N; pfam06468
59920002096	flavoprotein, HI0933 family; Region: TIGR00275
59920002097	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
59920002098	Predicted membrane protein [Function unknown]; Region: COG2259
59920002099	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
59920002100	Domain of unknown function DUF20; Region: UPF0118; pfam01594
59920002101	photosystem II reaction center protein Psb28; Provisional; Region: PRK13610
59920002102	tRNA 2-selenouridine synthase; Provisional; Region: PRK11784
59920002103	Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520
59920002104	active site residue [active]
59920002105	GUN4-like; Region: GUN4; pfam05419
59920002106	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
59920002107	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
59920002108	Methyltransferase domain; Region: Methyltransf_23; pfam13489
59920002109	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
59920002110	S-adenosylmethionine binding site [chemical binding]; other site
59920002111	glutamine synthetase, type I; Region: GlnA; TIGR00653
59920002112	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
59920002113	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
59920002114	Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451
59920002115	homodimer interface [polypeptide binding]; other site
59920002116	pyridoxal 5'-phosphate binding site [chemical binding]; other site
59920002117	catalytic residue [active]
59920002118	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
59920002119	nucleoside/Zn binding site; other site
59920002120	dimer interface [polypeptide binding]; other site
59920002121	catalytic motif [active]
59920002122	Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076
59920002123	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
59920002124	catalytic residue [active]
59920002125	GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100
59920002126	E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880
59920002127	G1 box; other site
59920002128	GTP/Mg2+ binding site [chemical binding]; other site
59920002129	Switch I region; other site
59920002130	G2 box; other site
59920002131	Switch II region; other site
59920002132	G3 box; other site
59920002133	G4 box; other site
59920002134	G5 box; other site
59920002135	Domain of unknown function (DUF697); Region: DUF697; pfam05128
59920002136	lipoprotein signal peptidase; Provisional; Region: PRK14792
59920002137	Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268
59920002138	Protein of unknown function (DUF3148); Region: DUF3148; pfam11347
59920002139	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
59920002140	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
59920002141	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
59920002142	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
59920002143	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
59920002144	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
59920002145	phycocyanobilin:ferredoxin oxidoreductase; Validated; Region: PRK02816
59920002146	ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971
59920002147	HlyD family secretion protein; Region: HlyD_3; pfam13437
59920002148	DevC protein; Region: devC; TIGR01185
59920002149	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
59920002150	FtsX-like permease family; Region: FtsX; pfam02687
59920002151	ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982
59920002152	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
59920002153	Walker A/P-loop; other site
59920002154	ATP binding site [chemical binding]; other site
59920002155	Q-loop/lid; other site
59920002156	ABC transporter signature motif; other site
59920002157	Walker B; other site
59920002158	D-loop; other site
59920002159	H-loop/switch region; other site
59920002160	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
59920002161	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
59920002162	Probable Catalytic site; other site
59920002163	metal-binding site
59920002164	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
59920002165	rRNA interaction site [nucleotide binding]; other site
59920002166	S8 interaction site; other site
59920002167	putative laminin-1 binding site; other site
59920002168	elongation factor Ts; Reviewed; Region: tsf; PRK12332
59920002169	UBA/TS-N domain; Region: UBA; pfam00627
59920002170	Elongation factor TS; Region: EF_TS; pfam00889
59920002171	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
59920002172	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
59920002173	generic binding surface II; other site
59920002174	ssDNA binding site; other site
59920002175	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
59920002176	ATP binding site [chemical binding]; other site
59920002177	putative Mg++ binding site [ion binding]; other site
59920002178	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
59920002179	nucleotide binding region [chemical binding]; other site
59920002180	ATP-binding site [chemical binding]; other site
59920002181	D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813
59920002182	sulfite reductase subunit beta; Provisional; Region: PRK13504
59920002183	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
59920002184	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
59920002185	Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092
59920002186	geranylgeranyl reductase; Region: ChlP; TIGR02028
59920002187	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
59920002188	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
59920002189	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
59920002190	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
59920002191	G1 box; other site
59920002192	putative GEF interaction site [polypeptide binding]; other site
59920002193	GTP/Mg2+ binding site [chemical binding]; other site
59920002194	Switch I region; other site
59920002195	G2 box; other site
59920002196	G3 box; other site
59920002197	Switch II region; other site
59920002198	G4 box; other site
59920002199	G5 box; other site
59920002200	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
59920002201	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
59920002202	Domain of unknown function (DUF309); Region: DUF309; pfam03745
59920002203	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
59920002204	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
59920002205	Walker A/P-loop; other site
59920002206	ATP binding site [chemical binding]; other site
59920002207	Q-loop/lid; other site
59920002208	ABC transporter signature motif; other site
59920002209	Walker B; other site
59920002210	D-loop; other site
59920002211	H-loop/switch region; other site
59920002212	Predicted permeases [General function prediction only]; Region: COG0795
59920002213	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
59920002214	cytochrome c biogenesis protein; Region: ccsA; CHL00045
59920002215	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
59920002216	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
59920002217	substrate binding site [chemical binding]; other site
59920002218	hexamer interface [polypeptide binding]; other site
59920002219	metal binding site [ion binding]; metal-binding site
59920002220	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
59920002221	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
59920002222	putative active site [active]
59920002223	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
59920002224	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
59920002225	tRNA; other site
59920002226	putative tRNA binding site [nucleotide binding]; other site
59920002227	putative NADP binding site [chemical binding]; other site
59920002228	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
59920002229	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862
59920002230	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
59920002231	ligand binding site; other site
59920002232	oligomer interface; other site
59920002233	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
59920002234	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
59920002235	dimer interface [polypeptide binding]; other site
59920002236	N-terminal domain interface [polypeptide binding]; other site
59920002237	sulfate 1 binding site; other site
59920002238	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
59920002239	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
59920002240	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
59920002241	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
59920002242	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
59920002243	putative active site [active]
59920002244	Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547
59920002245	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
59920002246	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309
59920002247	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
59920002248	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
59920002249	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
59920002250	cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475
59920002251	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
59920002252	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
59920002253	excinuclease ABC, A subunit; Region: uvra; TIGR00630
59920002254	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700
59920002255	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
59920002256	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
59920002257	putative active site [active]
59920002258	catalytic triad [active]
59920002259	Fructose-1,6-bisphosphate aldolase; Region: FBP_aldolase_I_a; cd00948
59920002260	active site
59920002261	intersubunit interface [polypeptide binding]; other site
59920002262	catalytic residue [active]
59920002263	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
59920002264	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
59920002265	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
59920002266	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
59920002267	RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717
59920002268	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
59920002269	Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029
59920002270	active site
59920002271	tartrate dehydrogenase; Region: TTC; TIGR02089
59920002272	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
59920002273	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
59920002274	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
59920002275	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
59920002276	trimer interface [polypeptide binding]; other site
59920002277	active site
59920002278	UDP-GlcNAc binding site [chemical binding]; other site
59920002279	lipid binding site [chemical binding]; lipid-binding site
59920002280	gamma-glutamyl kinase; Provisional; Region: PRK05429
59920002281	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
59920002282	nucleotide binding site [chemical binding]; other site
59920002283	homotetrameric interface [polypeptide binding]; other site
59920002284	putative phosphate binding site [ion binding]; other site
59920002285	putative allosteric binding site; other site
59920002286	PUA domain; Region: PUA; pfam01472
59920002287	Protein of unknown function (DUF3727); Region: DUF3727; pfam12527
59920002288	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
59920002289	F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996
59920002290	Protein of unknown function (DUF3685); Region: DUF3685; pfam12452
59920002291	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
59920002292	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
59920002293	catalytic residues [active]
59920002294	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
59920002295	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
59920002296	NAD(P) binding site [chemical binding]; other site
59920002297	active site
59920002298	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
59920002299	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
59920002300	Coenzyme A binding pocket [chemical binding]; other site
59920002301	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
59920002302	NADH(P)-binding; Region: NAD_binding_10; pfam13460
59920002303	NAD(P) binding site [chemical binding]; other site
59920002304	putative active site [active]
59920002305	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
59920002306	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
59920002307	minor groove reading motif; other site
59920002308	helix-hairpin-helix signature motif; other site
59920002309	substrate binding pocket [chemical binding]; other site
59920002310	active site
59920002311	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
59920002312	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
59920002313	Walker A/P-loop; other site
59920002314	ATP binding site [chemical binding]; other site
59920002315	Q-loop/lid; other site
59920002316	ABC transporter signature motif; other site
59920002317	Walker B; other site
59920002318	D-loop; other site
59920002319	H-loop/switch region; other site
59920002320	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
59920002321	Ferritin-like domain; Region: Ferritin; pfam00210
59920002322	ferroxidase diiron center [ion binding]; other site
59920002323	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
59920002324	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
59920002325	putative switch regulator; other site
59920002326	non-specific DNA interactions [nucleotide binding]; other site
59920002327	DNA binding site [nucleotide binding]
59920002328	sequence specific DNA binding site [nucleotide binding]; other site
59920002329	putative cAMP binding site [chemical binding]; other site
59920002330	chlorophyll a/b binding light-harvesting protein; Region: PS_antenn_a_b; TIGR03041
59920002331	AhpC/TSA antioxidant enzyme; Region: AhpC-TSA_2; pfam13911
59920002332	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
59920002333	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
59920002334	Walker A/P-loop; other site
59920002335	ATP binding site [chemical binding]; other site
59920002336	Q-loop/lid; other site
59920002337	ABC transporter signature motif; other site
59920002338	Walker B; other site
59920002339	D-loop; other site
59920002340	H-loop/switch region; other site
59920002341	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
59920002342	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
59920002343	[2Fe-2S] cluster binding site [ion binding]; other site
59920002344	UDP-glucose 4-epimerase; Region: PLN02240
59920002345	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
59920002346	NAD binding site [chemical binding]; other site
59920002347	homodimer interface [polypeptide binding]; other site
59920002348	active site
59920002349	substrate binding site [chemical binding]; other site
59920002350	L-asparaginase II; Region: Asparaginase_II; pfam06089
59920002351	Protein of unknown function (DUF1230); Region: DUF1230; pfam06799
59920002352	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
59920002353	Protein of unknown function (DUF3318); Region: DUF3318; pfam11780
59920002354	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
59920002355	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
59920002356	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
59920002357	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
59920002358	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
59920002359	ATP-grasp domain; Region: ATP-grasp_4; cl17255
59920002360	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
59920002361	IMP binding site; other site
59920002362	dimer interface [polypeptide binding]; other site
59920002363	interdomain contacts; other site
59920002364	partial ornithine binding site; other site
59920002365	magnesium-protoporphyrin IX monomethyl ester cyclase; Provisional; Region: PRK13654
59920002366	dinuclear metal binding motif [ion binding]; other site
59920002367	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
59920002368	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
59920002369	catalytic loop [active]
59920002370	iron binding site [ion binding]; other site
59920002371	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
59920002372	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
59920002373	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586
59920002374	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
59920002375	Walker A/P-loop; other site
59920002376	ATP binding site [chemical binding]; other site
59920002377	Q-loop/lid; other site
59920002378	ABC transporter signature motif; other site
59920002379	Walker B; other site
59920002380	D-loop; other site
59920002381	H-loop/switch region; other site
59920002382	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
59920002383	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
59920002384	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
59920002385	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
59920002386	Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236
59920002387	Protein of unknown function (DUF2862); Region: DUF2862; pfam11061
59920002388	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
59920002389	hypothetical protein; Provisional; Region: PRK10621
59920002390	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
59920002391	putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915
59920002392	Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356
59920002393	sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852
59920002394	active site
59920002395	homodimer interface [polypeptide binding]; other site
59920002396	catalytic site [active]
59920002397	mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK00192
59920002398	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
59920002399	active site
59920002400	motif I; other site
59920002401	motif II; other site
59920002402	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
59920002403	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
59920002404	active site
59920002405	T5orf172 domain; Region: T5orf172; cl17462
59920002406	Bacitracin resistance protein BacA; Region: BacA; pfam02673
59920002407	Peptide methionine sulfoxide reductase; Region: PMSR; cl00366
59920002408	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
59920002409	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
59920002410	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
59920002411	Walker A/P-loop; other site
59920002412	ATP binding site [chemical binding]; other site
59920002413	Q-loop/lid; other site
59920002414	ABC transporter signature motif; other site
59920002415	Walker B; other site
59920002416	D-loop; other site
59920002417	H-loop/switch region; other site
59920002418	Protein of unknown function (DUF3288); Region: DUF3288; pfam11691
59920002419	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
59920002420	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
59920002421	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
59920002422	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
59920002423	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988
59920002424	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
59920002425	catalytic site [active]
59920002426	subunit interface [polypeptide binding]; other site
59920002427	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
59920002428	anti sigma factor interaction site; other site
59920002429	regulatory phosphorylation site [posttranslational modification]; other site
59920002430	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cl00258
59920002431	active site
59920002432	metal binding site [ion binding]; metal-binding site
59920002433	dimerization interface [polypeptide binding]; other site
59920002434	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
59920002435	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
59920002436	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
59920002437	Domain of unknown function (DUF1816); Region: DUF1816; pfam08846
59920002438	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
59920002439	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
59920002440	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK07374
59920002441	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
59920002442	active site
59920002443	PHP Thumb interface [polypeptide binding]; other site
59920002444	metal binding site [ion binding]; metal-binding site
59920002445	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
59920002446	generic binding surface I; other site
59920002447	generic binding surface II; other site
59920002448	Protein of unknown function (DUF3464); Region: DUF3464; pfam11947
59920002449	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
59920002450	16S/18S rRNA binding site [nucleotide binding]; other site
59920002451	S13e-L30e interaction site [polypeptide binding]; other site
59920002452	25S rRNA binding site [nucleotide binding]; other site
59920002453	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
59920002454	RuvA N terminal domain; Region: RuvA_N; pfam01330
59920002455	Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470
59920002456	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
59920002457	EamA-like transporter family; Region: EamA; pfam00892
59920002458	DNA primase; Validated; Region: dnaG; PRK05667
59920002459	CHC2 zinc finger; Region: zf-CHC2; pfam01807
59920002460	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
59920002461	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
59920002462	active site
59920002463	metal binding site [ion binding]; metal-binding site
59920002464	interdomain interaction site; other site
59920002465	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
59920002466	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
59920002467	DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609
59920002468	active site
59920002469	DNA binding site [nucleotide binding]
59920002470	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
59920002471	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
59920002472	Catalytic site [active]
59920002473	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
59920002474	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
59920002475	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
59920002476	S-adenosylmethionine binding site [chemical binding]; other site
59920002477	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK02534
59920002478	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
59920002479	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
59920002480	Protein of unknown function (DUF3082); Region: DUF3082; pfam11282
59920002481	pyruvate dehydrogenase E1 component beta subunit; Validated; Region: odpB; CHL00144
59920002482	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
59920002483	alpha subunit interface [polypeptide binding]; other site
59920002484	TPP binding site [chemical binding]; other site
59920002485	heterodimer interface [polypeptide binding]; other site
59920002486	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
59920002487	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
59920002488	protein-export membrane protein SecD; Region: secD; TIGR01129
59920002489	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
59920002490	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
59920002491	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
59920002492	Protein export membrane protein; Region: SecD_SecF; cl14618
59920002493	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
59920002494	Predicted metal-binding protein (DUF2103); Region: DUF2103; pfam09876
59920002495	cytochrome b6-f complex subunit PetN; Provisional; Region: petN; PRK02529
59920002496	photosystem II biogenesis protein Psp29; Region: PS_II_psb29; TIGR03060
59920002497	Thf1-like protein; Reviewed; Region: PRK13266
59920002498	Clp protease; Region: CLP_protease; pfam00574
59920002499	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
59920002500	oligomer interface [polypeptide binding]; other site
59920002501	active site residues [active]
59920002502	cell division protein; Validated; Region: ftsH; CHL00176
59920002503	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
59920002504	Walker A motif; other site
59920002505	ATP binding site [chemical binding]; other site
59920002506	Walker B motif; other site
59920002507	arginine finger; other site
59920002508	Peptidase family M41; Region: Peptidase_M41; pfam01434
59920002509	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
59920002510	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
59920002511	FtsX-like permease family; Region: FtsX; pfam02687
59920002512	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
59920002513	Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469
59920002514	domain interfaces; other site
59920002515	active site
59920002516	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541
59920002517	putative metal binding site [ion binding]; other site
59920002518	YGGT family; Region: YGGT; pfam02325
59920002519	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
59920002520	threonine dehydratase; Reviewed; Region: PRK09224
59920002521	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
59920002522	tetramer interface [polypeptide binding]; other site
59920002523	pyridoxal 5'-phosphate binding site [chemical binding]; other site
59920002524	catalytic residue [active]
59920002525	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
59920002526	putative Ile/Val binding site [chemical binding]; other site
59920002527	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
59920002528	putative Ile/Val binding site [chemical binding]; other site
59920002529	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
59920002530	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
59920002531	TPP-binding site; other site
59920002532	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
59920002533	PYR/PP interface [polypeptide binding]; other site
59920002534	dimer interface [polypeptide binding]; other site
59920002535	TPP binding site [chemical binding]; other site
59920002536	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
59920002537	photosystem I reaction center subunit PsaK; Region: PS_I_psaK; TIGR03049
59920002538	Protein of unknown function (DUF3593); Region: DUF3593; pfam12159
59920002539	Protein of unknown function (DUF2499); Region: DUF2499; pfam10693
59920002540	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
59920002541	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
59920002542	catalytic triad [active]
59920002543	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
59920002544	heat shock protein 90; Provisional; Region: PRK05218
59920002545	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
59920002546	ATP binding site [chemical binding]; other site
59920002547	Mg2+ binding site [ion binding]; other site
59920002548	G-X-G motif; other site
59920002549	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292
59920002550	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
59920002551	dimer interface [polypeptide binding]; other site
59920002552	motif 1; other site
59920002553	active site
59920002554	motif 2; other site
59920002555	motif 3; other site
59920002556	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
59920002557	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
59920002558	active site
59920002559	dimerization interface [polypeptide binding]; other site
59920002560	phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14259
59920002561	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
59920002562	Walker A/P-loop; other site
59920002563	ATP binding site [chemical binding]; other site
59920002564	Q-loop/lid; other site
59920002565	ABC transporter signature motif; other site
59920002566	Walker B; other site
59920002567	D-loop; other site
59920002568	H-loop/switch region; other site
59920002569	phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
59920002570	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
59920002571	dimer interface [polypeptide binding]; other site
59920002572	conserved gate region; other site
59920002573	putative PBP binding loops; other site
59920002574	ABC-ATPase subunit interface; other site
59920002575	phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138
59920002576	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
59920002577	dimer interface [polypeptide binding]; other site
59920002578	conserved gate region; other site
59920002579	putative PBP binding loops; other site
59920002580	ABC-ATPase subunit interface; other site
59920002581	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
59920002582	molecular chaperone DnaK; Provisional; Region: PRK13410
59920002583	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
59920002584	nucleotide binding site [chemical binding]; other site
59920002585	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
59920002586	HSP70 interaction site [polypeptide binding]; other site
59920002587	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
59920002588	substrate binding site [polypeptide binding]; other site
59920002589	dimer interface [polypeptide binding]; other site
59920002590	Protein of unknown function (DUF3110); Region: DUF3110; pfam11360
59920002591	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
59920002592	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
59920002593	putative active site [active]
59920002594	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
59920002595	active site
59920002596	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II/unknown domain fusion protein; Provisional; Region: PRK09319
59920002597	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
59920002598	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
59920002599	dimerization interface [polypeptide binding]; other site
59920002600	active site
59920002601	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
59920002602	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
59920002603	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
59920002604	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
59920002605	active site
59920002606	substrate binding site [chemical binding]; other site
59920002607	cosubstrate binding site; other site
59920002608	catalytic site [active]
59920002609	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14096
59920002610	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
59920002611	active site
59920002612	dimer interface [polypeptide binding]; other site
59920002613	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
59920002614	dimer interface [polypeptide binding]; other site
59920002615	active site
59920002616	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
59920002617	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
59920002618	HIGH motif; other site
59920002619	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
59920002620	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
59920002621	active site
59920002622	KMSKS motif; other site
59920002623	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
59920002624	tRNA binding surface [nucleotide binding]; other site
59920002625	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
59920002626	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
59920002627	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
59920002628	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
59920002629	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
59920002630	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
59920002631	catalytic residue [active]
59920002632	Domain of unknown function (DUF1995); Region: DUF1995; pfam09353
59920002633	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
59920002634	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
59920002635	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
59920002636	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
59920002637	active site
59920002638	(T/H)XGH motif; other site
59920002639	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
59920002640	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
59920002641	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
59920002642	GIY-YIG motif/motif A; other site
59920002643	active site
59920002644	catalytic site [active]
59920002645	putative DNA binding site [nucleotide binding]; other site
59920002646	metal binding site [ion binding]; metal-binding site
59920002647	SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cl00137
59920002648	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
59920002649	Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653
59920002650	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
59920002651	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
59920002652	active site
59920002653	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
59920002654	CobN/Magnesium Chelatase; Region: CobN-Mg_chel; pfam02514
59920002655	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
59920002656	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
59920002657	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
59920002658	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
59920002659	homodimer interface [polypeptide binding]; other site
59920002660	substrate-cofactor binding pocket; other site
59920002661	catalytic residue [active]
59920002662	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
59920002663	5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082
59920002664	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
59920002665	substrate binding pocket [chemical binding]; other site
59920002666	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
59920002667	B12 binding site [chemical binding]; other site
59920002668	cobalt ligand [ion binding]; other site
59920002669	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
59920002670	ATP adenylyltransferase (5',5'''-P-1,P-4-tetraphosphate phosphorylase II) [Nucleotide transport and metabolism]; Region: APA2; COG4360
59920002671	ATP adenylyltransferase; Region: ATP_transf; pfam09830
59920002672	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
59920002673	HSP70 interaction site [polypeptide binding]; other site
59920002674	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
59920002675	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
59920002676	putative tRNA-binding site [nucleotide binding]; other site
59920002677	B3/4 domain; Region: B3_4; pfam03483
59920002678	tRNA synthetase B5 domain; Region: B5; smart00874
59920002679	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
59920002680	dimer interface [polypeptide binding]; other site
59920002681	motif 1; other site
59920002682	motif 3; other site
59920002683	motif 2; other site
59920002684	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896
59920002685	ribosomal protein L33; Region: rpl33; CHL00104
59920002686	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
59920002687	This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955
59920002688	RNB domain; Region: RNB; pfam00773
59920002689	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
59920002690	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
59920002691	active site
59920002692	HIGH motif; other site
59920002693	KMSKS motif; other site
59920002694	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
59920002695	tRNA binding surface [nucleotide binding]; other site
59920002696	anticodon binding site; other site
59920002697	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
59920002698	Protein of unknown function (DUF2930); Region: DUF2930; pfam11152
59920002699	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
59920002700	homotrimer interface [polypeptide binding]; other site
59920002701	Walker A motif; other site
59920002702	GTP binding site [chemical binding]; other site
59920002703	Walker B motif; other site
59920002704	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
59920002705	PPOX class probable FMN-dependent enzyme, alr4036 family; Region: PPOX_FMN_cyano; TIGR04026
59920002706	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxase_2; pfam12766
59920002707	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
59920002708	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
59920002709	dimer interface [polypeptide binding]; other site
59920002710	decamer (pentamer of dimers) interface [polypeptide binding]; other site
59920002711	catalytic triad [active]
59920002712	peroxidatic and resolving cysteines [active]
59920002713	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
59920002714	Protein of unknown function (DUF3529); Region: DUF3529; pfam12046
59920002715	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
59920002716	Walker A motif; other site
59920002717	ATP binding site [chemical binding]; other site
59920002718	Walker B motif; other site
59920002719	arginine finger; other site
59920002720	Peptidase family M41; Region: Peptidase_M41; pfam01434
59920002721	ribosomal protein L32; Validated; Region: rpl32; CHL00152
59920002722	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
59920002723	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
59920002724	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
59920002725	motif II; other site
59920002726	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
59920002727	DHH family; Region: DHH; pfam01368
59920002728	similar to hypothetical protein
59920002729	Predicted membrane protein [Function unknown]; Region: COG2119
59920002730	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
59920002731	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
59920002732	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
59920002733	This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955
59920002734	RNB domain; Region: RNB; pfam00773
59920002735	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
59920002736	RNA binding site [nucleotide binding]; other site
59920002737	aromatic acid decarboxylase; Validated; Region: PRK05920
59920002738	Flavoprotein; Region: Flavoprotein; pfam02441
59920002739	Protein of unknown function (DUF2996); Region: DUF2996; pfam11210
59920002740	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
59920002741	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
59920002742	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
59920002743	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
59920002744	putative active site [active]
59920002745	substrate binding site [chemical binding]; other site
59920002746	putative cosubstrate binding site; other site
59920002747	catalytic site [active]
59920002748	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
59920002749	substrate binding site [chemical binding]; other site
59920002750	Integral membrane protein TerC family; Region: TerC; cl10468
59920002751	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
59920002752	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559
59920002753	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
59920002754	ATP binding site [chemical binding]; other site
59920002755	putative Mg++ binding site [ion binding]; other site
59920002756	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
59920002757	nucleotide binding region [chemical binding]; other site
59920002758	ATP-binding site [chemical binding]; other site
59920002759	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
59920002760	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
59920002761	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
59920002762	Domain of unknown function (DUF4335); Region: DUF4335; pfam14233
59920002763	Protein of unknown function (DUF3038); Region: DUF3038; pfam11237
59920002764	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
59920002765	active site
59920002766	Protein of unknown function (DUF2949); Region: DUF2949; pfam11165
59920002767	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
59920002768	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
59920002769	dihydrodipicolinate reductase; Provisional; Region: PRK00048
59920002770	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
59920002771	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
59920002772	magnesium chelatase subunit H; Provisional; Region: PRK12493
59920002773	Domain of unknown function (DUF3479); Region: DUF3479; pfam11965
59920002774	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
59920002775	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
59920002776	dihydropteroate synthase; Region: DHPS; TIGR01496
59920002777	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
59920002778	substrate binding pocket [chemical binding]; other site
59920002779	dimer interface [polypeptide binding]; other site
59920002780	inhibitor binding site; inhibition site
59920002781	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
59920002782	triosephosphate isomerase; Provisional; Region: PRK14565
59920002783	substrate binding site [chemical binding]; other site
59920002784	dimer interface [polypeptide binding]; other site
59920002785	catalytic triad [active]
59920002786	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
59920002787	RNA binding surface [nucleotide binding]; other site
59920002788	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
59920002789	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
59920002790	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
59920002791	Walker A/P-loop; other site
59920002792	ATP binding site [chemical binding]; other site
59920002793	Q-loop/lid; other site
59920002794	ABC transporter signature motif; other site
59920002795	Walker B; other site
59920002796	D-loop; other site
59920002797	H-loop/switch region; other site
59920002798	Protein of unknown function (DUF1330); Region: DUF1330; cl02288
59920002799	Protein of unknown function (DUF2862); Region: DUF2862; pfam11061
59920002800	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
59920002801	active site
59920002802	NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251
59920002803	NmrA-like family; Region: NmrA; pfam05368
59920002804	NADP binding site [chemical binding]; other site
59920002805	active site
59920002806	regulatory binding site [polypeptide binding]; other site
59920002807	Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862
59920002808	Domain of unknown function (DUF3474); Region: DUF3474; pfam11960
59920002809	The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507
59920002810	Fatty acid desaturase; Region: FA_desaturase; pfam00487
59920002811	putative di-iron ligands [ion binding]; other site
59920002812	Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146
59920002813	active site pocket [active]
59920002814	oxyanion hole [active]
59920002815	catalytic triad [active]
59920002816	active site nucleophile [active]
59920002817	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
59920002818	NAD(P) binding site [chemical binding]; other site
59920002819	active site
59920002820	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
59920002821	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
59920002822	Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862
59920002823	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
59920002824	Ion channel; Region: Ion_trans_2; pfam07885
59920002825	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
59920002826	TrkA-N domain; Region: TrkA_N; pfam02254
59920002827	T5orf172 domain; Region: T5orf172; pfam10544
59920002828	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487
59920002829	Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903
59920002830	Protein of unknown function, DUF393; Region: DUF393; pfam04134
59920002831	AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250
59920002832	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295
59920002833	nucleotide binding pocket [chemical binding]; other site
59920002834	K-X-D-G motif; other site
59920002835	catalytic site [active]
59920002836	putative high light inducible protein; Region: PHA02337
59920002837	putative high light inducible protein; Region: PHA02337
59920002838	putative high light inducible protein; Region: PHA02337
59920002839	putative high light inducible protein; Region: PHA02337
59920002840	putative high light inducible protein; Region: PHA02337
59920002841	Protein of unknown function (DUF4090); Region: DUF4090; pfam13319
59920002842	Protein of unknown function (DUF938); Region: DUF938; pfam06080
59920002843	Transcription elongation factor Elf1 like; Region: Elf1; cl02038
59920002844	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295
59920002845	nucleotide binding pocket [chemical binding]; other site
59920002846	Domain of unknown function DUF77; Region: DUF77; pfam01910
59920002847	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
59920002848	dinuclear metal binding motif [ion binding]; other site
59920002849	putative high light inducible protein; Region: PHA02337
59920002850	putative high light inducible protein; Region: PHA02337
59920002851	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
59920002852	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
59920002853	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
59920002854	ligand binding site [chemical binding]; other site
59920002855	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
59920002856	putative switch regulator; other site
59920002857	non-specific DNA interactions [nucleotide binding]; other site
59920002858	DNA binding site [nucleotide binding]
59920002859	sequence specific DNA binding site [nucleotide binding]; other site
59920002860	putative cAMP binding site [chemical binding]; other site
59920002861	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
59920002862	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
59920002863	active site
59920002864	phosphorylation site [posttranslational modification]
59920002865	intermolecular recognition site; other site
59920002866	dimerization interface [polypeptide binding]; other site
59920002867	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
59920002868	DNA binding site [nucleotide binding]
59920002869	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
59920002870	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
59920002871	dimer interface [polypeptide binding]; other site
59920002872	phosphorylation site [posttranslational modification]
59920002873	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
59920002874	ATP binding site [chemical binding]; other site
59920002875	Mg2+ binding site [ion binding]; other site
59920002876	G-X-G motif; other site
59920002877	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
59920002878	PBP superfamily domain; Region: PBP_like_2; cl17296
59920002879	Chromate transporter; Region: Chromate_transp; pfam02417
59920002880	Chromate transporter; Region: Chromate_transp; pfam02417
59920002881	glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK08955
59920002882	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
59920002883	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
59920002884	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
59920002885	dimerization interface [polypeptide binding]; other site
59920002886	putative DNA binding site [nucleotide binding]; other site
59920002887	putative Zn2+ binding site [ion binding]; other site
59920002888	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
59920002889	Sodium Bile acid symporter family; Region: SBF; cl17470
59920002890	Protein of unknown function (DUF3804); Region: DUF3804; pfam12707
59920002891	Protein of unknown function (DUF3804); Region: DUF3804; pfam12707
59920002892	Protein of unknown function (DUF1651); Region: DUF1651; pfam07864
59920002893	Protein of unknown function, DUF; Region: DUF411; cl01142
59920002894	Protein of unknown function; Region: DUF3721; pfam12518
59920002895	Tryptophan-rich protein (DUF2389); Region: DUF2389; pfam09493
59920002896	Protein of unknown function (DUF1330); Region: DUF1330; pfam07045
59920002897	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
59920002898	MAPEG family; Region: MAPEG; pfam01124
59920002899	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
59920002900	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
59920002901	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
59920002902	Protein of unknown function (DUF3764); Region: DUF3764; pfam12594
59920002903	Predicted permeases [General function prediction only]; Region: COG0679
59920002904	Rhomboid family; Region: Rhomboid; cl11446
59920002905	carotene isomerase; Region: carot_isom; TIGR02730
59920002906	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
59920002907	Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547
59920002908	Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191
59920002909	Protein of unknown function (DUF3764); Region: DUF3764; pfam12594
59920002910	Protein of unknown function (DUF1499); Region: DUF1499; pfam07386
59920002911	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
59920002912	putative FMN binding site [chemical binding]; other site
59920002913	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
59920002914	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
59920002915	NAD binding site [chemical binding]; other site
59920002916	ATP-grasp domain; Region: ATP-grasp; pfam02222
59920002917	Protein of unknown function (DUF3804); Region: DUF3804; pfam12707
59920002918	putative high light inducible protein; Region: PHA02337
59920002919	putative high light inducible protein; Region: PHA02337
59920002920	putative high light inducible protein; Region: PHA02337
59920002921	putative high light inducible protein; Region: PHA02337
59920002922	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
59920002923	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
59920002924	catalytic triad [active]
59920002925	Protein of unknown function (DUF1499); Region: DUF1499; pfam07386
59920002926	Protein of unknown function (DUF1651); Region: DUF1651; pfam07864
59920002927	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
59920002928	TAP-like protein; Region: Abhydrolase_4; pfam08386
59920002929	haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549
59920002930	haloacid dehalogenase superfamily, subfamily IA hydrolase, TIGR01548; Region: HAD-SF-IA-hyp1
59920002931	Uncharacterized conserved protein [Function unknown]; Region: COG0397
59920002932	hypothetical protein; Validated; Region: PRK00029
59920002933	Protein of unknown function (DUF3303); Region: DUF3303; pfam11746
59920002934	Photosystem I reaction centre subunit IX / PsaJ; Region: PSI_PsaJ; cl03320
59920002935	putative high light inducible protein; Region: PHA02337
59920002936	putative high light inducible protein; Region: PHA02337
59920002937	putative high light inducible protein; Region: PHA02337
59920002938	putative high light inducible protein; Region: PHA02337
59920002939	putative high light inducible protein; Region: PHA02337
59920002940	AMP phosphorylase; Region: AMP_phos; TIGR03327
59920002941	Protein of unknown function (DUF2839); Region: DUF2839; pfam10999
59920002942	hypothetical protein; Provisional; Region: PRK09256
59920002943	D1 subunit  of photosystem II (PS II); Region: Photosystem-II_D1; cd09289
59920002944	protein I interface; other site
59920002945	D2 interface; other site
59920002946	protein T interface; other site
59920002947	chlorophyll binding site; other site
59920002948	beta carotene binding site; other site
59920002949	pheophytin binding site; other site
59920002950	manganese-stabilizing polypeptide interface; other site
59920002951	CP43 interface; other site
59920002952	protein L interface; other site
59920002953	oxygen evolving complex binding site; other site
59920002954	bromide binding site; other site
59920002955	quinone binding site; other site
59920002956	Fe binding site [ion binding]; other site
59920002957	core light harvesting interface; other site
59920002958	cytochrome b559 alpha subunit interface; other site
59920002959	cytochrome c-550 interface; other site
59920002960	protein J interface; other site
59920002961	endonuclease VIII; Provisional; Region: PRK10445
59920002962	N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965
59920002963	DNA binding site [nucleotide binding]
59920002964	catalytic residue [active]
59920002965	putative catalytic residues [active]
59920002966	H2TH interface [polypeptide binding]; other site
59920002967	intercalation triad [nucleotide binding]; other site
59920002968	substrate specificity determining residue; other site
59920002969	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
59920002970	PAP_fibrillin; Region: PAP_fibrillin; pfam04755
59920002971	Protein of unknown function (DUF2839); Region: DUF2839; pfam10999
59920002972	Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862
59920002973	putative high light inducible protein; Region: PHA02337
59920002974	putative high light inducible protein; Region: PHA02337
59920002975	putative high light inducible protein; Region: PHA02337
59920002976	putative high light inducible protein; Region: PHA02337
59920002977	Protein of unknown function (DUF2811); Region: DUF2811; pfam10929
59920002978	Protein of unknown function (DUF2811); Region: DUF2811; pfam10929
59920002979	Protein of unknown function (DUF3764); Region: DUF3764; pfam12594
59920002980	Protein of unknown function (DUF3104); Region: DUF3104; pfam11302
59920002981	Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378
59920002982	trimer interface [polypeptide binding]; other site
59920002983	putative Zn binding site [ion binding]; other site
59920002984	Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066
59920002985	GSH binding site [chemical binding]; other site
59920002986	catalytic residues [active]
59920002987	Protein of unknown function (DUF3104); Region: DUF3104; pfam11302
59920002988	Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982
59920002989	Cupin domain; Region: Cupin_2; pfam07883
59920002990	ATP-dependent Clp protease adaptor; Reviewed; Region: clpS; PRK13019
59920002991	Cupin domain; Region: Cupin_2; pfam07883
59920002992	Protein of unknown function (DUF2997); Region: DUF2997; pfam11211
59920002993	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
59920002994	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
59920002995	catalytic loop [active]
59920002996	iron binding site [ion binding]; other site
59920002997	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
59920002998	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
59920002999	RNA binding surface [nucleotide binding]; other site
59920003000	Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554
59920003001	probable active site [active]
59920003002	putative high light inducible protein; Region: PHA02337
59920003003	putative high light inducible protein; Region: PHA02337
59920003004	putative high light inducible protein; Region: PHA02337
59920003005	putative high light inducible protein; Region: PHA02337
59920003006	Protein of unknown function (DUF3104); Region: DUF3104; pfam11302
59920003007	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
59920003008	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
59920003009	Walker A/P-loop; other site
59920003010	ATP binding site [chemical binding]; other site
59920003011	Q-loop/lid; other site
59920003012	ABC transporter signature motif; other site
59920003013	Walker B; other site
59920003014	D-loop; other site
59920003015	H-loop/switch region; other site
59920003016	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
59920003017	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
59920003018	dimer interface [polypeptide binding]; other site
59920003019	conserved gate region; other site
59920003020	putative PBP binding loops; other site
59920003021	ABC-ATPase subunit interface; other site
59920003022	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
59920003023	dimer interface [polypeptide binding]; other site
59920003024	conserved gate region; other site
59920003025	ABC-ATPase subunit interface; other site
59920003026	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
59920003027	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
59920003028	substrate binding pocket [chemical binding]; other site
59920003029	membrane-bound complex binding site; other site
59920003030	hinge residues; other site
59920003031	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
59920003032	HupE / UreJ protein; Region: HupE_UreJ; cl01011
59920003033	Domain of unknown function (DUF4214); Region: DUF4214; pfam13946
59920003034	Domain of unknown function (DUF4214); Region: DUF4214; pfam13946
59920003035	menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012
59920003036	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
59920003037	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
59920003038	Sulfate transporter family; Region: Sulfate_transp; pfam00916
59920003039	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
59920003040	Protein of unknown function (DUF3303); Region: DUF3303; pfam11746
59920003041	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
59920003042	Glucose inhibited division protein A; Region: GIDA; pfam01134
59920003043	carotene isomerase; Region: carot_isom; TIGR02730
59920003044	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
59920003045	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
59920003046	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
59920003047	active site
59920003048	phosphorylation site [posttranslational modification]
59920003049	intermolecular recognition site; other site
59920003050	dimerization interface [polypeptide binding]; other site
59920003051	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
59920003052	DNA binding site [nucleotide binding]
59920003053	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
59920003054	putative GSH binding site [chemical binding]; other site
59920003055	catalytic residues [active]
59920003056	BolA-like protein; Region: BolA; pfam01722
59920003057	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
59920003058	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
59920003059	putative acyl-acceptor binding pocket; other site
59920003060	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
59920003061	active site
59920003062	hydrophilic channel; other site
59920003063	dimerization interface [polypeptide binding]; other site
59920003064	catalytic residues [active]
59920003065	active site lid [active]
59920003066	Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257
59920003067	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
59920003068	Phospholipid methyltransferase; Region: PEMT; cl17370
59920003069	ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074
59920003070	Part of AAA domain; Region: AAA_19; pfam13245
59920003071	exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447
59920003072	AAA domain; Region: AAA_30; pfam13604
59920003073	Family description; Region: UvrD_C_2; pfam13538
59920003074	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
59920003075	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
59920003076	ATP binding site [chemical binding]; other site
59920003077	Mg++ binding site [ion binding]; other site
59920003078	motif III; other site
59920003079	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
59920003080	nucleotide binding region [chemical binding]; other site
59920003081	ATP-binding site [chemical binding]; other site
59920003082	RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499
59920003083	putative RNA binding site [nucleotide binding]; other site
59920003084	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
59920003085	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
59920003086	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
59920003087	Walker A/P-loop; other site
59920003088	ATP binding site [chemical binding]; other site
59920003089	Q-loop/lid; other site
59920003090	ABC transporter signature motif; other site
59920003091	Walker B; other site
59920003092	D-loop; other site
59920003093	H-loop/switch region; other site
59920003094	PsbP; Region: PsbP; pfam01789
59920003095	recombination protein RecR; Reviewed; Region: recR; PRK00076
59920003096	RecR protein; Region: RecR; pfam02132
59920003097	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
59920003098	putative active site [active]
59920003099	putative metal-binding site [ion binding]; other site
59920003100	tetramer interface [polypeptide binding]; other site
59920003101	lipoyl synthase; Provisional; Region: PRK12928
59920003102	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
59920003103	FeS/SAM binding site; other site
59920003104	Predicted sulfurtransferase [General function prediction only]; Region: COG1054
59920003105	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
59920003106	active site residue [active]
59920003107	biotin synthase; Region: bioB; TIGR00433
59920003108	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
59920003109	FeS/SAM binding site; other site
59920003110	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
59920003111	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
59920003112	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
59920003113	catalytic residue [active]
59920003114	putative FPP diphosphate  binding site; other site
59920003115	putative FPP binding hydrophobic cleft; other site
59920003116	dimer interface [polypeptide binding]; other site
59920003117	putative IPP diphosphate binding site; other site
59920003118	Uncharacterized conserved protein [Function unknown]; Region: COG1624
59920003119	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
59920003120	diaminopimelate decarboxylase; Region: lysA; TIGR01048
59920003121	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
59920003122	active site
59920003123	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
59920003124	substrate binding site [chemical binding]; other site
59920003125	catalytic residues [active]
59920003126	dimer interface [polypeptide binding]; other site
59920003127	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
59920003128	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
59920003129	Coenzyme A binding pocket [chemical binding]; other site
59920003130	Clp protease ATP binding subunit; Region: clpC; CHL00095
59920003131	Clp amino terminal domain; Region: Clp_N; pfam02861
59920003132	Clp amino terminal domain; Region: Clp_N; pfam02861
59920003133	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
59920003134	Walker A motif; other site
59920003135	ATP binding site [chemical binding]; other site
59920003136	Walker B motif; other site
59920003137	arginine finger; other site
59920003138	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
59920003139	Walker A motif; other site
59920003140	ATP binding site [chemical binding]; other site
59920003141	Walker B motif; other site
59920003142	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
59920003143	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
59920003144	Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172
59920003145	putative active site [active]
59920003146	metal binding site [ion binding]; metal-binding site
59920003147	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
59920003148	PGAP1-like protein; Region: PGAP1; pfam07819
59920003149	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
59920003150	phosphatidate cytidylyltransferase; Region: PLN02953
59920003151	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
59920003152	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
59920003153	catalytic residue [active]
59920003154	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
59920003155	ABC1 family; Region: ABC1; cl17513
59920003156	Helix-turn-helix domain; Region: HTH_25; pfam13413
59920003157	non-specific DNA binding site [nucleotide binding]; other site
59920003158	salt bridge; other site
59920003159	sequence-specific DNA binding site [nucleotide binding]; other site
59920003160	4-alpha-glucanotransferase; Provisional; Region: PRK14508
59920003161	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02812
59920003162	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
59920003163	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
59920003164	active site
59920003165	aminopeptidase N; Provisional; Region: pepN; PRK14015
59920003166	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
59920003167	Zn binding site [ion binding]; other site
59920003168	adaptive-response sensory kinase; Validated; Region: PRK09303
59920003169	KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978
59920003170	tetramer interface [polypeptide binding]; other site
59920003171	dimer interface [polypeptide binding]; other site
59920003172	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
59920003173	dimer interface [polypeptide binding]; other site
59920003174	phosphorylation site [posttranslational modification]
59920003175	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
59920003176	ATP binding site [chemical binding]; other site
59920003177	Mg2+ binding site [ion binding]; other site
59920003178	G-X-G motif; other site
59920003179	ferredoxin--NADP+ reductase; Provisional; Region: PLN03116
59920003180	These ferredoxin reductases are related to the NADPH cytochrome p450 reductases (CYPOR), but lack the FAD-binding region connecting sub-domain. Ferredoxin-NADP+ reductase (FNR) is an FAD-containing enzyme that catalyzes the reversible electron transfer...; Region: CYPOR_like_FNR; cd06208
59920003181	dimerization interface [polypeptide binding]; other site
59920003182	FAD binding pocket [chemical binding]; other site
59920003183	FAD binding motif [chemical binding]; other site
59920003184	catalytic residues [active]
59920003185	NAD binding pocket [chemical binding]; other site
59920003186	phosphate binding motif [ion binding]; other site
59920003187	beta-alpha-beta structure motif; other site
59920003188	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
59920003189	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
59920003190	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
59920003191	Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128
59920003192	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
59920003193	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
59920003194	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
59920003195	catalytic triad [active]
59920003196	AAA domain; Region: AAA_30; pfam13604
59920003197	Family description; Region: UvrD_C_2; pfam13538
59920003198	Divergent PAP2 family; Region: DUF212; pfam02681
59920003199	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
59920003200	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
59920003201	substrate binding pocket [chemical binding]; other site
59920003202	chain length determination region; other site
59920003203	substrate-Mg2+ binding site; other site
59920003204	catalytic residues [active]
59920003205	aspartate-rich region 1; other site
59920003206	active site lid residues [active]
59920003207	aspartate-rich region 2; other site
59920003208	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14186
59920003209	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
59920003210	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
59920003211	homodimer interface [polypeptide binding]; other site
59920003212	NADP binding site [chemical binding]; other site
59920003213	substrate binding site [chemical binding]; other site
59920003214	Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480
59920003215	7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698
59920003216	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
59920003217	Zn2+ binding site [ion binding]; other site
59920003218	Mg2+ binding site [ion binding]; other site
59920003219	2-isopropylmalate synthase; Validated; Region: PRK00915
59920003220	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
59920003221	active site
59920003222	catalytic residues [active]
59920003223	metal binding site [ion binding]; metal-binding site
59920003224	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
59920003225	Uncharacterized conserved protein [Function unknown]; Region: COG1543
59920003226	N-terminal catalytic domain of  alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792
59920003227	active site
59920003228	substrate binding site [chemical binding]; other site
59920003229	catalytic site [active]
59920003230	Domain of unknown function (DUF1957); Region: DUF1957; pfam09210
59920003231	lycopene cyclase family protein; Region: carotene-cycl; TIGR01790
59920003232	lycopene cyclase; Region: lycopene_cycl; TIGR01789
59920003233	DNA gyrase subunit A; Validated; Region: PRK05560
59920003234	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
59920003235	CAP-like domain; other site
59920003236	active site
59920003237	primary dimer interface [polypeptide binding]; other site
59920003238	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
59920003239	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
59920003240	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
59920003241	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
59920003242	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
59920003243	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649
59920003244	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
59920003245	active site
59920003246	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
59920003247	catalytic residues [active]
59920003248	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
59920003249	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
59920003250	putative active site [active]
59920003251	oxyanion strand; other site
59920003252	catalytic triad [active]
59920003253	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
59920003254	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
59920003255	S-adenosylmethionine binding site [chemical binding]; other site
59920003256	Cytochrome B6-F complex subunit 5; Region: PetG; pfam02529
59920003257	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
59920003258	Cytochrome c; Region: Cytochrom_C; pfam00034
59920003259	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
59920003260	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
59920003261	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
59920003262	Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081
59920003263	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
59920003264	Walker A motif; other site
59920003265	ATP binding site [chemical binding]; other site
59920003266	Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039
59920003267	active site
59920003268	putative DNA-binding cleft [nucleotide binding]; other site
59920003269	dimer interface [polypeptide binding]; other site
59920003270	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
59920003271	Fe-S metabolism associated domain; Region: SufE; cl00951
59920003272	homoserine dehydrogenase; Provisional; Region: PRK06349
59920003273	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
59920003274	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
59920003275	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
59920003276	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
59920003277	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
59920003278	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
59920003279	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
59920003280	Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176
59920003281	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
59920003282	Protein of unknown function (DUF2834); Region: DUF2834; pfam11196
59920003283	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
59920003284	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
59920003285	substrate binding site [chemical binding]; other site
59920003286	ATP binding site [chemical binding]; other site
59920003287	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
59920003288	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
59920003289	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
59920003290	macrophage migration inhibition factor-like protein; Provisional; Region: PTZ00397
59920003291	Protein of unknown function, DUF393; Region: DUF393; pfam04134
59920003292	chlorophyll a/b binding light-harvesting protein; Region: PS_antenn_a_b; TIGR03041
59920003293	chlorophyll a/b binding light-harvesting protein; Region: PS_antenn_a_b; TIGR03041
59920003294	chlorophyll a/b binding light-harvesting protein; Region: PS_antenn_a_b; TIGR03041
59920003295	chlorophyll a/b binding light-harvesting protein; Region: PS_antenn_a_b; TIGR03041
59920003296	chlorophyll a/b binding light-harvesting protein; Region: PS_antenn_a_b; TIGR03041
59920003297	Protein of unknown function (DUF2805); Region: DUF2805; pfam10985
59920003298	Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013
59920003299	Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046
59920003300	Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244
59920003301	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
59920003302	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
59920003303	catalytic triad [active]
59920003304	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
59920003305	short chain dehydrogenase; Provisional; Region: PRK06197
59920003306	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
59920003307	putative NAD(P) binding site [chemical binding]; other site
59920003308	active site
59920003309	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
59920003310	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
59920003311	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
59920003312	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
59920003313	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
59920003314	Uncharacterized conserved protein [Function unknown]; Region: COG2308
59920003315	Domain of unknown function (DUF4214); Region: DUF4214; pfam13946
59920003316	D1 subunit  of photosystem II (PS II); Region: Photosystem-II_D1; cd09289
59920003317	protein I interface; other site
59920003318	D2 interface; other site
59920003319	protein T interface; other site
59920003320	chlorophyll binding site; other site
59920003321	beta carotene binding site; other site
59920003322	pheophytin binding site; other site
59920003323	manganese-stabilizing polypeptide interface; other site
59920003324	CP43 interface; other site
59920003325	protein L interface; other site
59920003326	oxygen evolving complex binding site; other site
59920003327	bromide binding site; other site
59920003328	quinone binding site; other site
59920003329	Fe binding site [ion binding]; other site
59920003330	core light harvesting interface; other site
59920003331	cytochrome b559 alpha subunit interface; other site
59920003332	cytochrome c-550 interface; other site
59920003333	protein J interface; other site
59920003334	Domain of unknown function (DUF4214); Region: DUF4214; pfam13946
59920003335	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
59920003336	TPR motif; other site
59920003337	TPR repeat; Region: TPR_11; pfam13414
59920003338	binding surface
59920003339	TPR repeat; Region: TPR_11; pfam13414
59920003340	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
59920003341	binding surface
59920003342	TPR motif; other site
59920003343	TPR repeat; Region: TPR_11; pfam13414
59920003344	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
59920003345	binding surface
59920003346	TPR motif; other site
59920003347	Tetratricopeptide repeat; Region: TPR_12; pfam13424
59920003348	Domain of unknown function (DUF4214); Region: DUF4214; pfam13946
59920003349	Domain of unknown function (DUF4214); Region: DUF4214; pfam13946
59920003350	Domain of unknown function (DUF4214); Region: DUF4214; pfam13946
59920003351	Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277
59920003352	active site
59920003353	Domain of unknown function (DUF4214); Region: DUF4214; pfam13946
59920003354	Domain of unknown function (DUF4214); Region: DUF4214; pfam13946
59920003355	Domain of unknown function (DUF4214); Region: DUF4214; pfam13946
59920003356	Domain of unknown function (DUF4214); Region: DUF4214; pfam13946
59920003357	Domain of unknown function (DUF4214); Region: DUF4214; pfam13946
59920003358	Domain of unknown function (DUF4214); Region: DUF4214; pfam13946
59920003359	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
59920003360	Domain of unknown function (DUF4214); Region: DUF4214; pfam13946
59920003361	Domain of unknown function (DUF4214); Region: DUF4214; pfam13946
59920003362	GTP-binding protein YchF; Reviewed; Region: PRK09601
59920003363	YchF GTPase; Region: YchF; cd01900
59920003364	G1 box; other site
59920003365	GTP/Mg2+ binding site [chemical binding]; other site
59920003366	Switch I region; other site
59920003367	G2 box; other site
59920003368	Switch II region; other site
59920003369	G3 box; other site
59920003370	G4 box; other site
59920003371	G5 box; other site
59920003372	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
59920003373	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
59920003374	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
59920003375	HlyD family secretion protein; Region: HlyD_3; pfam13437
59920003376	DNA polymerase I; Provisional; Region: PRK05755
59920003377	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
59920003378	active site
59920003379	metal binding site 1 [ion binding]; metal-binding site
59920003380	putative 5' ssDNA interaction site; other site
59920003381	metal binding site 3; metal-binding site
59920003382	metal binding site 2 [ion binding]; metal-binding site
59920003383	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
59920003384	putative DNA binding site [nucleotide binding]; other site
59920003385	putative metal binding site [ion binding]; other site
59920003386	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
59920003387	active site
59920003388	catalytic site [active]
59920003389	substrate binding site [chemical binding]; other site
59920003390	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
59920003391	active site
59920003392	DNA binding site [nucleotide binding]
59920003393	catalytic site [active]
59920003394	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
59920003395	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
59920003396	active site
59920003397	HIGH motif; other site
59920003398	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
59920003399	KMSKS motif; other site
59920003400	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
59920003401	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
59920003402	Na2 binding site [ion binding]; other site
59920003403	putative substrate binding site 1 [chemical binding]; other site
59920003404	Na binding site 1 [ion binding]; other site
59920003405	putative substrate binding site 2 [chemical binding]; other site
59920003406	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
59920003407	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
59920003408	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
59920003409	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
59920003410	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429
59920003411	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
59920003412	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
59920003413	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
59920003414	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
59920003415	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
59920003416	ligand binding site [chemical binding]; other site
59920003417	homodimer interface [polypeptide binding]; other site
59920003418	NAD(P) binding site [chemical binding]; other site
59920003419	trimer interface B [polypeptide binding]; other site
59920003420	trimer interface A [polypeptide binding]; other site
59920003421	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
59920003422	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
59920003423	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
59920003424	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
59920003425	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
59920003426	rRNA binding site [nucleotide binding]; other site
59920003427	predicted 30S ribosome binding site; other site
59920003428	Ycf39; Provisional; Region: ycf39; CHL00194
59920003429	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
59920003430	NAD(P) binding site [chemical binding]; other site
59920003431	putative active site [active]
59920003432	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
59920003433	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
59920003434	acetohydroxyacid synthase small subunit; Region: ilvH; CHL00100
59920003435	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
59920003436	putative valine binding site [chemical binding]; other site
59920003437	dimer interface [polypeptide binding]; other site
59920003438	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
59920003439	Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD; Region: Pro_isomerase; pfam00160
59920003440	active site
59920003441	photosystem I assembly protein Ycf4; Provisional; Region: PRK02542
59920003442	photosystem II protein D2; Region: psbD; CHL00004
59920003443	pheophytin binding site; other site
59920003444	chlorophyll binding site; other site
59920003445	quinone binding site; other site
59920003446	Fe binding site [ion binding]; other site
59920003447	Photosystem II protein; Region: PSII; cl08223
59920003448	photosystem II 44 kDa subunit reaction center protein (also called P6 protein, CP43), bacterial and chloroplast; Region: psbC; TIGR01153
59920003449	Maf-like protein; Region: Maf; pfam02545
59920003450	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
59920003451	active site
59920003452	dimer interface [polypeptide binding]; other site
59920003453	cobyric acid synthase; Provisional; Region: PRK00784
59920003454	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
59920003455	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
59920003456	catalytic triad [active]
59920003457	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
59920003458	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
59920003459	catalytic loop [active]
59920003460	iron binding site [ion binding]; other site
59920003461	Interferon-induced transmembrane protein; Region: CD225; pfam04505
59920003462	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
59920003463	Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467
59920003464	Carbohydrate-selective porin, OprB family; Region: OprB; cl17816
59920003465	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
59920003466	dimer interface [polypeptide binding]; other site
59920003467	motif 1; other site
59920003468	active site
59920003469	motif 2; other site
59920003470	motif 3; other site
59920003471	Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626
59920003472	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974
59920003473	Uncharacterized conserved protein (DUF2358); Region: DUF2358; pfam10184
59920003474	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
59920003475	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
59920003476	catalytic triad [active]
59920003477	Tetratricopeptide repeat; Region: TPR_16; pfam13432
59920003478	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
59920003479	binding surface
59920003480	TPR motif; other site
59920003481	TPR repeat; Region: TPR_11; pfam13414
59920003482	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
59920003483	TPR motif; other site
59920003484	binding surface
59920003485	TPR repeat; Region: TPR_11; pfam13414
59920003486	Methyltransferase domain; Region: Methyltransf_31; pfam13847
59920003487	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
59920003488	S-adenosylmethionine binding site [chemical binding]; other site
59920003489	Uncharacterized conserved protein [Function unknown]; Region: COG4095
59920003490	cytochrome b559 subunit beta; Provisional; Region: psbF; PRK02561
59920003491	flavodoxin FldA; Validated; Region: PRK09267
59920003492	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
59920003493	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
59920003494	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
59920003495	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
59920003496	putative ADP-binding pocket [chemical binding]; other site
59920003497	EamA-like transporter family; Region: EamA; pfam00892
59920003498	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
59920003499	EamA-like transporter family; Region: EamA; pfam00892
59920003500	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
59920003501	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
59920003502	tandem repeat interface [polypeptide binding]; other site
59920003503	oligomer interface [polypeptide binding]; other site
59920003504	active site residues [active]
59920003505	Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185
59920003506	homotrimer interaction site [polypeptide binding]; other site
59920003507	active site
59920003508	Protein of unknown function (DUF2808); Region: DUF2808; pfam10989
59920003509	Ribonuclease P; Region: Ribonuclease_P; pfam00825
59920003510	Bacterial PH domain; Region: DUF304; pfam03703
59920003511	putative inner membrane protein translocase component YidC; Provisional; Region: PRK02654
59920003512	60Kd inner membrane protein; Region: 60KD_IMP; pfam02096
59920003513	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
59920003514	Ycf46; Provisional; Region: ycf46; CHL00195
59920003515	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
59920003516	ATP binding site [chemical binding]; other site
59920003517	Walker A motif; other site
59920003518	Walker B motif; other site
59920003519	arginine finger; other site
59920003520	seryl-tRNA synthetase; Provisional; Region: PRK05431
59920003521	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
59920003522	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
59920003523	dimer interface [polypeptide binding]; other site
59920003524	active site
59920003525	motif 1; other site
59920003526	motif 2; other site
59920003527	motif 3; other site
59920003528	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
59920003529	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
59920003530	active site
59920003531	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
59920003532	protein binding site [polypeptide binding]; other site
59920003533	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
59920003534	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
59920003535	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
59920003536	RNase E interface [polypeptide binding]; other site
59920003537	trimer interface [polypeptide binding]; other site
59920003538	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
59920003539	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
59920003540	RNase E interface [polypeptide binding]; other site
59920003541	trimer interface [polypeptide binding]; other site
59920003542	active site
59920003543	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
59920003544	putative nucleic acid binding region [nucleotide binding]; other site
59920003545	G-X-X-G motif; other site
59920003546	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
59920003547	RNA binding site [nucleotide binding]; other site
59920003548	domain interface; other site
59920003549	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
59920003550	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
59920003551	active site
59920003552	Predicted methyltransferases [General function prediction only]; Region: COG0313
59920003553	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
59920003554	putative SAM binding site [chemical binding]; other site
59920003555	putative homodimer interface [polypeptide binding]; other site
59920003556	acetylglucosaminyltransferase  family protein; Provisional; Region: PLN03183
59920003557	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
59920003558	binding surface
59920003559	TPR motif; other site
59920003560	TPR repeat; Region: TPR_11; pfam13414
59920003561	TPR repeat; Region: TPR_11; pfam13414
59920003562	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
59920003563	binding surface
59920003564	TPR motif; other site
59920003565	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304
59920003566	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
59920003567	binding surface
59920003568	TPR motif; other site
59920003569	TPR repeat; Region: TPR_11; pfam13414
59920003570	Methyltransferase domain; Region: Methyltransf_31; pfam13847
59920003571	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
59920003572	S-adenosylmethionine binding site [chemical binding]; other site
59920003573	Predicted membrane protein (DUF2214); Region: DUF2214; pfam09980
59920003574	Formyltransferase, catalytic core domain; Region: FMT_core; cl00395
59920003575	active site
59920003576	cosubstrate binding site; other site
59920003577	substrate binding site [chemical binding]; other site
59920003578	catalytic site [active]
59920003579	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
59920003580	Coenzyme A binding pocket [chemical binding]; other site
59920003581	WbqC-like protein family; Region: WbqC; pfam08889
59920003582	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
59920003583	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156
59920003584	TPR repeat; Region: TPR_11; pfam13414
59920003585	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
59920003586	binding surface
59920003587	TPR motif; other site
59920003588	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
59920003589	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
59920003590	binding surface
59920003591	TPR motif; other site
59920003592	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
59920003593	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
59920003594	inhibitor-cofactor binding pocket; inhibition site
59920003595	pyridoxal 5'-phosphate binding site [chemical binding]; other site
59920003596	catalytic residue [active]
59920003597	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
59920003598	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
59920003599	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
59920003600	Catalytic site [active]
59920003601	ornithine carbamoyltransferase; Provisional; Region: PRK00779
59920003602	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
59920003603	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
59920003604	FtsH Extracellular; Region: FtsH_ext; pfam06480
59920003605	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
59920003606	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
59920003607	Walker A motif; other site
59920003608	ATP binding site [chemical binding]; other site
59920003609	Walker B motif; other site
59920003610	arginine finger; other site
59920003611	Peptidase family M41; Region: Peptidase_M41; pfam01434
59920003612	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
59920003613	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
59920003614	catalytic motif [active]
59920003615	Zn binding site [ion binding]; other site
59920003616	RibD C-terminal domain; Region: RibD_C; cl17279
59920003617	Protein of unknown function (DUF3122); Region: DUF3122; pfam11320
59920003618	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
59920003619	active site
59920003620	putative homodimer interface [polypeptide binding]; other site
59920003621	SAM binding site [chemical binding]; other site
59920003622	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
59920003623	precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; Region: CbiT; TIGR02469
59920003624	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02649
59920003625	ATP-NAD kinase; Region: NAD_kinase; pfam01513
59920003626	phenylalanyl-tRNA synthetase, alpha subunit; Region: pheS; TIGR00468
59920003627	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
59920003628	dimer interface [polypeptide binding]; other site
59920003629	motif 1; other site
59920003630	active site
59920003631	motif 2; other site
59920003632	motif 3; other site
59920003633	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
59920003634	Protein of unknown function (DUF3611); Region: DUF3611; pfam12263
59920003635	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
59920003636	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
59920003637	active site
59920003638	Riboflavin kinase; Region: Flavokinase; smart00904
59920003639	thiamine-phosphate pyrophosphorylase; Provisional; Region: PRK02615
59920003640	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
59920003641	thiamine phosphate binding site [chemical binding]; other site
59920003642	active site
59920003643	pyrophosphate binding site [ion binding]; other site
59920003644	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
59920003645	thiS-thiF/thiG interaction site; other site
59920003646	Protein of unknown function (DUF1517); Region: DUF1517; pfam07466
59920003647	AIR carboxylase; Region: AIRC; smart01001
59920003648	uncharacterized cyanobacterial protein, TIGR03792 family; Region: TIGR03792
59920003649	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
59920003650	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
59920003651	homotrimer interaction site [polypeptide binding]; other site
59920003652	zinc binding site [ion binding]; other site
59920003653	CDP-binding sites; other site
59920003654	GTPase Era; Reviewed; Region: era; PRK00089
59920003655	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
59920003656	G1 box; other site
59920003657	GTP/Mg2+ binding site [chemical binding]; other site
59920003658	Switch I region; other site
59920003659	G2 box; other site
59920003660	Switch II region; other site
59920003661	G3 box; other site
59920003662	G4 box; other site
59920003663	G5 box; other site
59920003664	KH domain; Region: KH_2; pfam07650
59920003665	BAX inhibitor (BI)-1/YccA-like protein family; Region: BI-1-like; cl00473
59920003666	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
59920003667	PhoH-like protein; Region: PhoH; pfam02562
59920003668	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
59920003669	signal recognition particle protein; Provisional; Region: PRK10867
59920003670	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
59920003671	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
59920003672	GTP binding site [chemical binding]; other site
59920003673	Signal peptide binding domain; Region: SRP_SPB; pfam02978
59920003674	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
59920003675	Protein of unknown function (DUF4101); Region: DUF4101; pfam13355
59920003676	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
59920003677	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
59920003678	tetramer interface [polypeptide binding]; other site
59920003679	TPP-binding site [chemical binding]; other site
59920003680	heterodimer interface [polypeptide binding]; other site
59920003681	phosphorylation loop region [posttranslational modification]
59920003682	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
59920003683	RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997
59920003684	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
59920003685	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
59920003686	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
59920003687	DNA binding residues [nucleotide binding]
59920003688	Uncharacterized conserved protein [Function unknown]; Region: COG0062
59920003689	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
59920003690	putative substrate binding site [chemical binding]; other site
59920003691	putative ATP binding site [chemical binding]; other site
59920003692	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
59920003693	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
59920003694	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
59920003695	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
59920003696	putative active site [active]
59920003697	catalytic triad [active]
59920003698	putative dimer interface [polypeptide binding]; other site
59920003699	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
59920003700	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
59920003701	superoxide dismutase, Ni; Region: sodN; TIGR02753
59920003702	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
59920003703	Catalytic site [active]
59920003704	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
59920003705	active site
59920003706	ribulose/triose binding site [chemical binding]; other site
59920003707	phosphate binding site [ion binding]; other site
59920003708	substrate (anthranilate) binding pocket [chemical binding]; other site
59920003709	product (indole) binding pocket [chemical binding]; other site
59920003710	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
59920003711	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
59920003712	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
59920003713	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
59920003714	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
59920003715	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
59920003716	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
59920003717	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
59920003718	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
59920003719	hinge; other site
59920003720	active site
59920003721	acetylornithine aminotransferase; Provisional; Region: PRK02627
59920003722	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
59920003723	inhibitor-cofactor binding pocket; inhibition site
59920003724	pyridoxal 5'-phosphate binding site [chemical binding]; other site
59920003725	catalytic residue [active]
59920003726	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
59920003727	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
59920003728	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
59920003729	FAD binding domain; Region: FAD_binding_4; pfam01565
59920003730	cytosine deaminase-like protein; Validated; Region: PRK07583
59920003731	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
59920003732	active site
59920003733	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14333
59920003734	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
59920003735	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
59920003736	FeS/SAM binding site; other site
59920003737	TRAM domain; Region: TRAM; pfam01938
59920003738	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
59920003739	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
59920003740	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
59920003741	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
59920003742	cell division protein FtsZ; Validated; Region: PRK09330
59920003743	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
59920003744	nucleotide binding site [chemical binding]; other site
59920003745	SulA interaction site; other site
59920003746	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
59920003747	oligomerization interface [polypeptide binding]; other site
59920003748	active site
59920003749	metal binding site [ion binding]; metal-binding site
59920003750	coproporphyrinogen III oxidase; Provisional; Region: PRK07379
59920003751	Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956
59920003752	PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877
59920003753	putative active site [active]
59920003754	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
59920003755	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
59920003756	oligomer interface [polypeptide binding]; other site
59920003757	active site residues [active]
59920003758	Clp protease; Region: CLP_protease; pfam00574
59920003759	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
59920003760	oligomer interface [polypeptide binding]; other site
59920003761	active site residues [active]
59920003762	ketol-acid reductoisomerase; Provisional; Region: PRK05479
59920003763	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
59920003764	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
59920003765	CobD/Cbib protein; Region: CobD_Cbib; pfam03186
59920003766	Bacterial sugar transferase; Region: Bac_transf; pfam02397
59920003767	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
59920003768	This family is most closely related to the GT1 family of glycosyltransferases.  wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804
59920003769	putative ADP-binding pocket [chemical binding]; other site
59920003770	NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07376
59920003771	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
59920003772	IHF dimer interface [polypeptide binding]; other site
59920003773	IHF - DNA interface [nucleotide binding]; other site
59920003774	Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523
59920003775	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
59920003776	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
59920003777	active site
59920003778	catalytic site [active]
59920003779	MFS/sugar transport protein; Region: MFS_2; pfam13347
59920003780	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
59920003781	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
59920003782	Permease; Region: Permease; pfam02405
59920003783	Protein of unknown function (DUF3119); Region: DUF3119; pfam11317
59920003784	Protein of unknown function (DUF3086); Region: DUF3086; pfam11285
59920003785	membrane protein; Provisional; Region: PRK14419
59920003786	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
59920003787	active site
59920003788	dimer interface [polypeptide binding]; other site
59920003789	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
59920003790	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
59920003791	active site
59920003792	HIGH motif; other site
59920003793	dimer interface [polypeptide binding]; other site
59920003794	KMSKS motif; other site
59920003795	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
59920003796	RNA binding surface [nucleotide binding]; other site
59920003797	Domain of unknown function (DUF1825); Region: DUF1825; pfam08855
59920003798	multifunctional aminopeptidase A; Provisional; Region: PRK00913
59920003799	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
59920003800	interface (dimer of trimers) [polypeptide binding]; other site
59920003801	Substrate-binding/catalytic site; other site
59920003802	Zn-binding sites [ion binding]; other site
59920003803	Peptide methionine sulfoxide reductase; Region: PMSR; pfam01625
59920003804	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
59920003805	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
59920003806	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
59920003807	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
59920003808	active site
59920003809	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
59920003810	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
59920003811	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
59920003812	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
59920003813	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
59920003814	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
59920003815	Surface antigen; Region: Bac_surface_Ag; pfam01103
59920003816	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
59920003817	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
59920003818	ATP binding site [chemical binding]; other site
59920003819	active site
59920003820	substrate binding site [chemical binding]; other site
59920003821	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
59920003822	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
59920003823	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
59920003824	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
59920003825	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
59920003826	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
59920003827	dimerization interface [polypeptide binding]; other site
59920003828	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
59920003829	putative active site [active]
59920003830	heme pocket [chemical binding]; other site
59920003831	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
59920003832	dimer interface [polypeptide binding]; other site
59920003833	phosphorylation site [posttranslational modification]
59920003834	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
59920003835	ATP binding site [chemical binding]; other site
59920003836	Mg2+ binding site [ion binding]; other site
59920003837	G-X-G motif; other site
59920003838	circadian clock protein KaiC; Reviewed; Region: PRK09302
59920003839	KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124
59920003840	Walker A motif; other site
59920003841	ATP binding site [chemical binding]; other site
59920003842	Walker B motif; other site
59920003843	recA bacterial DNA recombination protein; Region: RecA; cl17211
59920003844	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
59920003845	Walker A motif; other site
59920003846	ATP binding site [chemical binding]; other site
59920003847	Walker B motif; other site
59920003848	KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978
59920003849	tetramer interface [polypeptide binding]; other site
59920003850	dimer interface [polypeptide binding]; other site
59920003851	ribosomal protein L21; Region: rpl21; CHL00075
59920003852	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
59920003853	Methyltransferase domain; Region: Methyltransf_23; pfam13489
59920003854	Methyltransferase domain; Region: Methyltransf_12; pfam08242
59920003855	S-adenosylmethionine binding site [chemical binding]; other site
59920003856	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02755
59920003857	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
59920003858	RNA binding site [nucleotide binding]; other site
59920003859	active site
59920003860	Stage II sporulation protein; Region: SpoIID; pfam08486
59920003861	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
59920003862	ribonuclease Z; Region: RNase_Z; TIGR02651
59920003863	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
59920003864	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
59920003865	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
59920003866	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
59920003867	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
59920003868	catalytic loop [active]
59920003869	iron binding site [ion binding]; other site
59920003870	ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517
59920003871	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
59920003872	S-adenosylmethionine binding site [chemical binding]; other site
59920003873	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
59920003874	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
59920003875	ligand binding site [chemical binding]; other site
59920003876	NAD binding site [chemical binding]; other site
59920003877	dimerization interface [polypeptide binding]; other site
59920003878	catalytic site [active]
59920003879	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
59920003880	putative L-serine binding site [chemical binding]; other site
59920003881	photosystem II S4 domain protein; Region: PS_II_S4; TIGR03069
59920003882	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
59920003883	RNA binding surface [nucleotide binding]; other site
59920003884	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02705
59920003885	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
59920003886	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
59920003887	GAF domain; Region: GAF; pfam01590
59920003888	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
59920003889	DoxX; Region: DoxX; pfam07681
59920003890	OsmC-like protein; Region: OsmC; pfam02566
59920003891	putative high light inducible protein; Region: PHA02337
59920003892	putative high light inducible protein; Region: PHA02337
59920003893	putative high light inducible protein; Region: PHA02337
59920003894	Protein of unknown function (DUF3386); Region: DUF3386; pfam11866
59920003895	putative high light inducible protein; Region: PHA02337
59920003896	putative high light inducible protein; Region: PHA02337
59920003897	Protein of unknown function (DUF3007); Region: DUF3007; pfam11460
59920003898	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
59920003899	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
59920003900	Walker A/P-loop; other site
59920003901	ATP binding site [chemical binding]; other site
59920003902	ABC transporter signature motif; other site
59920003903	Walker B; other site
59920003904	D-loop; other site
59920003905	H-loop/switch region; other site
59920003906	ABC transporter; Region: ABC_tran_2; pfam12848
59920003907	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
59920003908	Walker A/P-loop; other site
59920003909	ATP binding site [chemical binding]; other site
59920003910	Q-loop/lid; other site
59920003911	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
59920003912	ABC transporter signature motif; other site
59920003913	Walker B; other site
59920003914	D-loop; other site
59920003915	Protein of unknown function (DUF805); Region: DUF805; cl01224
59920003916	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627
59920003917	TPR repeat; Region: TPR_11; pfam13414
59920003918	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
59920003919	binding surface
59920003920	TPR repeat; Region: TPR_11; pfam13414
59920003921	TPR motif; other site
59920003922	TPR repeat; Region: TPR_11; pfam13414
59920003923	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
59920003924	binding surface
59920003925	TPR motif; other site
59920003926	TPR repeat; Region: TPR_11; pfam13414
59920003927	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
59920003928	TPR motif; other site
59920003929	TPR repeat; Region: TPR_11; pfam13414
59920003930	binding surface
59920003931	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
59920003932	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
59920003933	Protein of unknown function (DUF861); Region: Cupin_3; pfam05899
59920003934	EVE domain; Region: EVE; cl00728
59920003935	Protein of unknown function (DUF2811); Region: DUF2811; pfam10929
59920003936	Domain of unknown function (DUF1818); Region: DUF1818; pfam08848
59920003937	RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651
59920003938	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
59920003939	nucleotide binding site [chemical binding]; other site
59920003940	putative NEF/HSP70 interaction site [polypeptide binding]; other site
59920003941	SBD interface [polypeptide binding]; other site
59920003942	phosphoglyceromutase; Provisional; Region: PRK05434
59920003943	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
59920003944	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
59920003945	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
59920003946	ring oligomerisation interface [polypeptide binding]; other site
59920003947	ATP/Mg binding site [chemical binding]; other site
59920003948	stacking interactions; other site
59920003949	hinge regions; other site
59920003950	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
59920003951	oligomerisation interface [polypeptide binding]; other site
59920003952	mobile loop; other site
59920003953	roof hairpin; other site
59920003954	ATP synthase CF1 beta subunit; Region: atpB; CHL00060
59920003955	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
59920003956	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
59920003957	alpha subunit interaction interface [polypeptide binding]; other site
59920003958	Walker A motif; other site
59920003959	ATP binding site [chemical binding]; other site
59920003960	Walker B motif; other site
59920003961	inhibitor binding site; inhibition site
59920003962	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
59920003963	ATP synthase CF1 epsilon subunit; Region: atpE; CHL00063
59920003964	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
59920003965	gamma subunit interface [polypeptide binding]; other site
59920003966	epsilon subunit interface [polypeptide binding]; other site
59920003967	LBP interface [polypeptide binding]; other site
59920003968	hypothetical protein; Provisional; Region: PRK02724
59920003969	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
59920003970	proline aminopeptidase P II; Provisional; Region: PRK10879
59920003971	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
59920003972	active site
59920003973	Domain of unknown function DUF21; Region: DUF21; pfam01595
59920003974	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
59920003975	Dynamin family; Region: Dynamin_N; pfam00350
59920003976	E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880
59920003977	G1 box; other site
59920003978	GTP/Mg2+ binding site [chemical binding]; other site
59920003979	Switch I region; other site
59920003980	G2 box; other site
59920003981	Switch II region; other site
59920003982	G3 box; other site
59920003983	G4 box; other site
59920003984	G5 box; other site
59920003985	Domain of unknown function (DUF697); Region: DUF697; pfam05128
59920003986	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
59920003987	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
59920003988	active site
59920003989	(T/H)XGH motif; other site
59920003990	NAD synthetase; Provisional; Region: PRK13981
59920003991	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
59920003992	multimer interface [polypeptide binding]; other site
59920003993	active site
59920003994	catalytic triad [active]
59920003995	protein interface 1 [polypeptide binding]; other site
59920003996	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
59920003997	homodimer interface [polypeptide binding]; other site
59920003998	NAD binding pocket [chemical binding]; other site
59920003999	ATP binding pocket [chemical binding]; other site
59920004000	Mg binding site [ion binding]; other site
59920004001	active-site loop [active]
59920004002	Protein of unknown function (DUF3326); Region: DUF3326; pfam11805
59920004003	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
59920004004	core domain interface [polypeptide binding]; other site
59920004005	delta subunit interface [polypeptide binding]; other site
59920004006	epsilon subunit interface [polypeptide binding]; other site
59920004007	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
59920004008	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
59920004009	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
59920004010	beta subunit interaction interface [polypeptide binding]; other site
59920004011	Walker A motif; other site
59920004012	ATP binding site [chemical binding]; other site
59920004013	Walker B motif; other site
59920004014	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
59920004015	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
59920004016	F0F1 ATP synthase subunit delta; Provisional; Region: PRK13429
59920004017	F0F1 ATP synthase subunit B; Validated; Region: PRK07352
59920004018	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
59920004019	F0F1 ATP synthase subunit B'; Validated; Region: PRK07353
59920004020	ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430
59920004021	ATP synthase CF0 C subunit; Region: atpH; CHL00061
59920004022	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
59920004023	ATP synthase CF0 A subunit; Region: atpI; CHL00046
59920004024	Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098
59920004025	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
59920004026	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
59920004027	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
59920004028	ResB-like family; Region: ResB; pfam05140
59920004029	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
59920004030	Nitrogen regulatory protein P-II; Region: P-II; pfam00543
59920004031	Nitrogen regulatory protein P-II; Region: P-II; smart00938
59920004032	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
59920004033	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
59920004034	RNA binding surface [nucleotide binding]; other site
59920004035	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
59920004036	adenylosuccinate lyase; Provisional; Region: PRK07380
59920004037	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
59920004038	tetramer interface [polypeptide binding]; other site
59920004039	active site
59920004040	Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998
59920004041	fumarate hydratase; Reviewed; Region: fumC; PRK00485
59920004042	Class II fumarases; Region: Fumarase_classII; cd01362
59920004043	active site
59920004044	tetramer interface [polypeptide binding]; other site
59920004045	Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581
59920004046	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
59920004047	ATP binding site [chemical binding]; other site
59920004048	putative Mg++ binding site [ion binding]; other site
59920004049	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
59920004050	nucleotide binding region [chemical binding]; other site
59920004051	ATP-binding site [chemical binding]; other site
59920004052	DSHCT (NUC185) domain; Region: DSHCT; pfam08148
59920004053	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
59920004054	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
59920004055	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
59920004056	catalytic residue [active]
59920004057	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
59920004058	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
59920004059	S-adenosylmethionine binding site [chemical binding]; other site
59920004060	AAA domain; Region: AAA_26; pfam13500
59920004061	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
59920004062	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
59920004063	adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508
59920004064	inhibitor-cofactor binding pocket; inhibition site
59920004065	pyridoxal 5'-phosphate binding site [chemical binding]; other site
59920004066	catalytic residue [active]
59920004067	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
59920004068	HSP70 interaction site [polypeptide binding]; other site
59920004069	rRNA small subunit methyltransferase G; Region: GidB; pfam02527
59920004070	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
59920004071	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
59920004072	Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453
59920004073	active site
59920004074	catalytic tetrad [active]
59920004075	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
59920004076	Protein of unknown function (DUF1257); Region: DUF1257; pfam06868
59920004077	Protein of unknown function (DUF2997); Region: DUF2997; pfam11211
59920004078	HEAT repeats; Region: HEAT_2; pfam13646
59920004079	HEAT repeats; Region: HEAT_2; pfam13646
59920004080	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477
59920004081	Na binding site [ion binding]; other site
59920004082	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14457
59920004083	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
59920004084	FeS/SAM binding site; other site
59920004085	DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597
59920004086	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
59920004087	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
59920004088	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
59920004089	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
59920004090	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
59920004091	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
59920004092	DNA binding site [nucleotide binding]
59920004093	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
59920004094	DNA-directed RNA polymerase subunit gamma; Provisional; Region: rpoC1; PRK02625
59920004095	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
59920004096	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
59920004097	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
59920004098	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
59920004099	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
59920004100	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
59920004101	RPB1 interaction site [polypeptide binding]; other site
59920004102	RPB10 interaction site [polypeptide binding]; other site
59920004103	RPB11 interaction site [polypeptide binding]; other site
59920004104	RPB3 interaction site [polypeptide binding]; other site
59920004105	RPB12 interaction site [polypeptide binding]; other site
59920004106	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
59920004107	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
59920004108	active site
59920004109	ribosomal protein S20; Region: rps20; CHL00102
59920004110	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
59920004111	histidinol dehydrogenase; Region: hisD; TIGR00069
59920004112	NAD binding site [chemical binding]; other site
59920004113	dimerization interface [polypeptide binding]; other site
59920004114	product binding site; other site
59920004115	substrate binding site [chemical binding]; other site
59920004116	zinc binding site [ion binding]; other site
59920004117	catalytic residues [active]
59920004118	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
59920004119	tetramer (dimer of dimers) interface [polypeptide binding]; other site
59920004120	active site
59920004121	dimer interface [polypeptide binding]; other site
59920004122	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
59920004123	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
59920004124	protein binding site [polypeptide binding]; other site
59920004125	Sm and related proteins; Region: Sm_like; cl00259
59920004126	ribosome maturation protein RimP; Reviewed; Region: PRK00092
59920004127	heptamer interface [polypeptide binding]; other site
59920004128	Sm1 motif; other site
59920004129	hexamer interface [polypeptide binding]; other site
59920004130	RNA binding site [nucleotide binding]; other site
59920004131	Sm2 motif; other site
59920004132	transcription elongation factor NusA; Provisional; Region: nusA; PRK12329
59920004133	NusA N-terminal domain; Region: NusA_N; pfam08529
59920004134	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
59920004135	RNA binding site [nucleotide binding]; other site
59920004136	homodimer interface [polypeptide binding]; other site
59920004137	NusA-like KH domain; Region: KH_5; pfam13184
59920004138	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
59920004139	G-X-X-G motif; other site
59920004140	Protein of unknown function (DUF448); Region: DUF448; pfam04296
59920004141	putative RNA binding cleft [nucleotide binding]; other site
59920004142	AF-4 proto-oncoprotein; Region: AF-4; pfam05110
59920004143	translation initiation factor IF-2; Validated; Region: infB; PRK05306
59920004144	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
59920004145	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
59920004146	G1 box; other site
59920004147	putative GEF interaction site [polypeptide binding]; other site
59920004148	GTP/Mg2+ binding site [chemical binding]; other site
59920004149	Switch I region; other site
59920004150	G2 box; other site
59920004151	G3 box; other site
59920004152	Switch II region; other site
59920004153	G4 box; other site
59920004154	G5 box; other site
59920004155	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
59920004156	Translation-initiation factor 2; Region: IF-2; pfam11987
59920004157	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
59920004158	Protein of unknown function (DUF3493); Region: DUF3493; pfam11998
59920004159	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
59920004160	GTP cyclohydrolase I; Provisional; Region: PLN03044
59920004161	active site
59920004162	Protein of unknown function; Region: DUF3721; pfam12518
59920004163	GLTT repeat (6 copies); Region: GLTT; pfam01744
59920004164	GLTT repeat (6 copies); Region: GLTT; pfam01744
59920004165	Protein of unknown function; Region: DUF3721; pfam12518
59920004166	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
59920004167	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
59920004168	ABC-ATPase subunit  interface; other site
59920004169	dimer interface [polypeptide binding]; other site
59920004170	putative PBP binding regions; other site
59920004171	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
59920004172	metal binding site 2 [ion binding]; metal-binding site
59920004173	putative DNA binding helix; other site
59920004174	metal binding site 1 [ion binding]; metal-binding site
59920004175	dimer interface [polypeptide binding]; other site
59920004176	structural Zn2+ binding site [ion binding]; other site
59920004177	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
59920004178	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
59920004179	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
59920004180	intersubunit interface [polypeptide binding]; other site
59920004181	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
59920004182	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
59920004183	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
59920004184	The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112
59920004185	P-loop, Walker A motif; other site
59920004186	Base recognition motif; other site
59920004187	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
59920004188	FOG: WD40 repeat [General function prediction only]; Region: COG2319
59920004189	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
59920004190	structural tetrad; other site
59920004191	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304
59920004192	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
59920004193	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
59920004194	Walker A/P-loop; other site
59920004195	ATP binding site [chemical binding]; other site
59920004196	Q-loop/lid; other site
59920004197	ABC transporter signature motif; other site
59920004198	Walker B; other site
59920004199	D-loop; other site
59920004200	H-loop/switch region; other site
59920004201	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
59920004202	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
59920004203	Walker A/P-loop; other site
59920004204	ATP binding site [chemical binding]; other site
59920004205	Q-loop/lid; other site
59920004206	ABC transporter signature motif; other site
59920004207	Walker B; other site
59920004208	D-loop; other site
59920004209	H-loop/switch region; other site
59920004210	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
59920004211	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
59920004212	TM-ABC transporter signature motif; other site
59920004213	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
59920004214	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
59920004215	TM-ABC transporter signature motif; other site
59920004216	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
59920004217	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
59920004218	putative ligand binding site [chemical binding]; other site
59920004219	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
59920004220	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
59920004221	UreF; Region: UreF; pfam01730
59920004222	urease accessory protein UreE; Provisional; Region: ureE; PRK13261
59920004223	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
59920004224	dimer interface [polypeptide binding]; other site
59920004225	catalytic residues [active]
59920004226	UreD urease accessory protein; Region: UreD; pfam01774
59920004227	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
59920004228	alpha-gamma subunit interface [polypeptide binding]; other site
59920004229	beta-gamma subunit interface [polypeptide binding]; other site
59920004230	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
59920004231	gamma-beta subunit interface [polypeptide binding]; other site
59920004232	alpha-beta subunit interface [polypeptide binding]; other site
59920004233	urease subunit alpha; Reviewed; Region: ureC; PRK13207
59920004234	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
59920004235	subunit interactions [polypeptide binding]; other site
59920004236	active site
59920004237	flap region; other site
59920004238	Domain of unknown function (DUF1830); Region: DUF1830; pfam08865
59920004239	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
59920004240	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
59920004241	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
59920004242	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
59920004243	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
59920004244	Radical SAM superfamily; Region: Radical_SAM; pfam04055
59920004245	FeS/SAM binding site; other site
59920004246	CAAX protease self-immunity; Region: Abi; pfam02517
59920004247	ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033
59920004248	L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590
59920004249	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
59920004250	pyridoxal 5'-phosphate binding site [chemical binding]; other site
59920004251	homodimer interface [polypeptide binding]; other site
59920004252	catalytic residue [active]
59920004253	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
59920004254	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
59920004255	homodimer interface [polypeptide binding]; other site
59920004256	oligonucleotide binding site [chemical binding]; other site
59920004257	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
59920004258	RNA/DNA hybrid binding site [nucleotide binding]; other site
59920004259	active site
59920004260	Protein of unknown function (DUF1997); Region: DUF1997; pfam09366
59920004261	prephenate dehydratase; Provisional; Region: PRK11898
59920004262	Prephenate dehydratase; Region: PDT; pfam00800
59920004263	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
59920004264	putative L-Phe binding site [chemical binding]; other site
59920004265	tocopherol O-methyltransferase; Region: PLN02244
59920004266	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
59920004267	S-adenosylmethionine binding site [chemical binding]; other site
59920004268	ATP-dependent protease La (LON) domain; Region: LON; pfam02190
59920004269	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
59920004270	elongation factor Tu; Reviewed; Region: PRK00049
59920004271	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
59920004272	G1 box; other site
59920004273	GEF interaction site [polypeptide binding]; other site
59920004274	GTP/Mg2+ binding site [chemical binding]; other site
59920004275	Switch I region; other site
59920004276	G2 box; other site
59920004277	G3 box; other site
59920004278	Switch II region; other site
59920004279	G4 box; other site
59920004280	G5 box; other site
59920004281	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
59920004282	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
59920004283	Antibiotic Binding Site [chemical binding]; other site
59920004284	elongation factor G; Reviewed; Region: PRK00007
59920004285	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
59920004286	G1 box; other site
59920004287	putative GEF interaction site [polypeptide binding]; other site
59920004288	GTP/Mg2+ binding site [chemical binding]; other site
59920004289	Switch I region; other site
59920004290	G2 box; other site
59920004291	G3 box; other site
59920004292	Switch II region; other site
59920004293	G4 box; other site
59920004294	G5 box; other site
59920004295	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
59920004296	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
59920004297	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
59920004298	30S ribosomal protein S7; Validated; Region: PRK05302
59920004299	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
59920004300	S17 interaction site [polypeptide binding]; other site
59920004301	S8 interaction site; other site
59920004302	16S rRNA interaction site [nucleotide binding]; other site
59920004303	streptomycin interaction site [chemical binding]; other site
59920004304	23S rRNA interaction site [nucleotide binding]; other site
59920004305	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
59920004306	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
59920004307	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
59920004308	active site
59920004309	dimer interface [polypeptide binding]; other site
59920004310	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
59920004311	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
59920004312	active site
59920004313	FMN binding site [chemical binding]; other site
59920004314	substrate binding site [chemical binding]; other site
59920004315	3Fe-4S cluster binding site [ion binding]; other site
59920004316	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
59920004317	domain interface; other site
59920004318	lipoyl synthase; Provisional; Region: PRK05481
59920004319	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
59920004320	FeS/SAM binding site; other site
59920004321	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
59920004322	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
59920004323	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
59920004324	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
59920004325	active site
59920004326	SAM binding site [chemical binding]; other site
59920004327	homodimer interface [polypeptide binding]; other site
59920004328	photosystem I P700 chlorophyll a apoprotein A1; Provisional; Region: psaA; PRK13200
59920004329	photosystem I P700 chlorophyll a apoprotein A2; Provisional; Region: psaB; PRK13199
59920004330	photosystem I reaction center protein subunit XI; Provisional; Region: PRK00704
59920004331	photosystem I reaction center subunit VIII; Reviewed; Region: psaI; PRK11877
59920004332	HEAT repeats; Region: HEAT_2; pfam13646
59920004333	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
59920004334	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
59920004335	Ligand binding site; other site
59920004336	Putative Catalytic site; other site
59920004337	DXD motif; other site
59920004338	NlpC/P60 family; Region: NLPC_P60; pfam00877
59920004339	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
59920004340	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
59920004341	TPR repeat; Region: TPR_11; pfam13414
59920004342	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
59920004343	binding surface
59920004344	TPR motif; other site
59920004345	TPR repeat; Region: TPR_11; pfam13414
59920004346	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
59920004347	TPR motif; other site
59920004348	TPR repeat; Region: TPR_11; pfam13414
59920004349	binding surface
59920004350	TPR repeat; Region: TPR_11; pfam13414
59920004351	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
59920004352	binding surface
59920004353	TPR motif; other site
59920004354	TPR repeat; Region: TPR_11; pfam13414
59920004355	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
59920004356	binding surface
59920004357	TPR motif; other site
59920004358	Putative 2OG-Fe(II) oxygenase; Region: 2OG-FeII_Oxy_5; pfam13759
59920004359	TPR repeat; Region: TPR_11; pfam13414
59920004360	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
59920004361	binding surface
59920004362	TPR motif; other site
59920004363	TPR repeat; Region: TPR_11; pfam13414
59920004364	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
59920004365	TPR motif; other site
59920004366	TPR repeat; Region: TPR_11; pfam13414
59920004367	binding surface
59920004368	TPR repeat; Region: TPR_11; pfam13414
59920004369	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
59920004370	binding surface
59920004371	TPR motif; other site
59920004372	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
59920004373	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
59920004374	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
59920004375	binding surface
59920004376	TPR motif; other site
59920004377	TPR repeat; Region: TPR_11; pfam13414
59920004378	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
59920004379	binding surface
59920004380	TPR motif; other site
59920004381	TPR repeat; Region: TPR_11; pfam13414
59920004382	TPR repeat; Region: TPR_11; pfam13414
59920004383	Tetratricopeptide repeat; Region: TPR_16; pfam13432
59920004384	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
59920004385	binding surface
59920004386	TPR motif; other site
59920004387	TPR repeat; Region: TPR_11; pfam13414
59920004388	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
59920004389	binding surface
59920004390	TPR motif; other site
59920004391	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
59920004392	Sulfotransferase family; Region: Sulfotransfer_3; pfam13469
59920004393	alanine racemase; Reviewed; Region: alr; PRK00053
59920004394	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
59920004395	active site
59920004396	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
59920004397	dimer interface [polypeptide binding]; other site
59920004398	substrate binding site [chemical binding]; other site
59920004399	catalytic residues [active]
59920004400	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
59920004401	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
59920004402	active site
59920004403	peptide chain release factor 1; Validated; Region: prfA; PRK00591
59920004404	This domain is found in peptide chain release factors; Region: PCRF; smart00937
59920004405	RF-1 domain; Region: RF-1; pfam00472
59920004406	ribosomal protein L31; Validated; Region: rpl31; CHL00136
59920004407	ribosomal protein S9; Region: rps9; CHL00079
59920004408	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
59920004409	23S rRNA interface [nucleotide binding]; other site
59920004410	L3 interface [polypeptide binding]; other site
59920004411	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
59920004412	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
59920004413	dimerization interface 3.5A [polypeptide binding]; other site
59920004414	active site
59920004415	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
59920004416	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
59920004417	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
59920004418	alphaNTD homodimer interface [polypeptide binding]; other site
59920004419	alphaNTD - beta interaction site [polypeptide binding]; other site
59920004420	alphaNTD - beta' interaction site [polypeptide binding]; other site
59920004421	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
59920004422	30S ribosomal protein S11; Validated; Region: PRK05309
59920004423	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
59920004424	30S ribosomal protein S13; Region: bact_S13; TIGR03631
59920004425	Ribosomal protein L36; Region: Ribosomal_L36; pfam00444
59920004426	adenylate kinase; Provisional; Region: PRK14531
59920004427	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
59920004428	AMP-binding site [chemical binding]; other site
59920004429	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
59920004430	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
59920004431	SecY translocase; Region: SecY; pfam00344
59920004432	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
59920004433	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
59920004434	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
59920004435	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
59920004436	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
59920004437	5S rRNA interface [nucleotide binding]; other site
59920004438	L27 interface [polypeptide binding]; other site
59920004439	23S rRNA interface [nucleotide binding]; other site
59920004440	L5 interface [polypeptide binding]; other site
59920004441	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
59920004442	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
59920004443	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
59920004444	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
59920004445	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
59920004446	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
59920004447	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
59920004448	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
59920004449	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
59920004450	RNA binding site [nucleotide binding]; other site
59920004451	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
59920004452	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
59920004453	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
59920004454	23S rRNA interface [nucleotide binding]; other site
59920004455	putative translocon interaction site; other site
59920004456	signal recognition particle (SRP54) interaction site; other site
59920004457	L23 interface [polypeptide binding]; other site
59920004458	trigger factor interaction site; other site
59920004459	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
59920004460	23S rRNA interface [nucleotide binding]; other site
59920004461	5S rRNA interface [nucleotide binding]; other site
59920004462	putative antibiotic binding site [chemical binding]; other site
59920004463	L25 interface [polypeptide binding]; other site
59920004464	L27 interface [polypeptide binding]; other site
59920004465	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
59920004466	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
59920004467	G-X-X-G motif; other site
59920004468	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
59920004469	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
59920004470	putative translocon binding site; other site
59920004471	protein-rRNA interface [nucleotide binding]; other site
59920004472	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
59920004473	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
59920004474	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
59920004475	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
59920004476	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
59920004477	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
59920004478	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
59920004479	NADH-quinone oxidoreductase cyanobacterial subunit N; Region: NdhN; pfam11909
59920004480	Ferredoxin [Energy production and conversion]; Region: COG1146
59920004481	Iron-Sulfur binding protein C terminal; Region: LdpA_C; pfam12617
59920004482	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
59920004483	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
59920004484	RecA/RadA recombinase [DNA replication, recombination, and repair]; Region: RecA; COG0468
59920004485	hexamer interface [polypeptide binding]; other site
59920004486	Walker A motif; other site
59920004487	ATP binding site [chemical binding]; other site
59920004488	Walker B motif; other site
59920004489	Protein of unknown function (DUF2839); Region: DUF2839; pfam10999
59920004490	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
59920004491	arogenate dehydrogenase; Reviewed; Region: PRK07417
59920004492	prephenate dehydrogenase; Validated; Region: PRK08507
59920004493	C-3',4' desaturase CrtD; Region: desat_CrtD; TIGR02733
59920004494	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
59920004495	Fructosamine kinase; Region: Fructosamin_kin; cl17579
59920004496	Domain of unknown function (DUF4308); Region: DUF4308; pfam14159
59920004497	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070
59920004498	MPN+ (JAMM) motif; other site
59920004499	Zinc-binding site [ion binding]; other site
59920004500	hypothetical protein; Validated; Region: PRK07411
59920004501	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
59920004502	ATP binding site [chemical binding]; other site
59920004503	substrate interface [chemical binding]; other site
59920004504	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
59920004505	active site residue [active]
59920004506	hypothetical protein; Validated; Region: PRK07413
59920004507	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
59920004508	homodimer interface [polypeptide binding]; other site
59920004509	Walker A motif; other site
59920004510	ATP binding site [chemical binding]; other site
59920004511	hydroxycobalamin binding site [chemical binding]; other site
59920004512	Walker B motif; other site
59920004513	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; pfam02572
59920004514	ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606
59920004515	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_I; cd01990
59920004516	Ligand Binding Site [chemical binding]; other site
59920004517	S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK02770
59920004518	recombination protein F; Reviewed; Region: recF; PRK00064
59920004519	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
59920004520	Walker A/P-loop; other site
59920004521	ATP binding site [chemical binding]; other site
59920004522	Q-loop/lid; other site
59920004523	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
59920004524	ABC transporter signature motif; other site
59920004525	Walker B; other site
59920004526	D-loop; other site
59920004527	H-loop/switch region; other site
59920004528	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
59920004529	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
59920004530	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
59920004531	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
59920004532	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
59920004533	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
59920004534	PsaD; Region: PsaD; pfam02531
59920004535	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
59920004536	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
59920004537	dimer interface [polypeptide binding]; other site
59920004538	phosphorylation site [posttranslational modification]
59920004539	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
59920004540	Domain of unknown function DUF59; Region: DUF59; pfam01883
59920004541	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
59920004542	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
59920004543	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
59920004544	Protein of unknown function (DUF3529); Region: DUF3529; pfam12046
59920004545	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
59920004546	catalytic site [active]
59920004547	putative active site [active]
59920004548	putative substrate binding site [chemical binding]; other site
59920004549	conserved hypothetical protein; Region: TIGR03492
59920004550	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370
59920004551	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
59920004552	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
59920004553	active site
59920004554	catalytic tetrad [active]
59920004555	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
59920004556	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
59920004557	dimerization interface [polypeptide binding]; other site
59920004558	putative ATP binding site [chemical binding]; other site
59920004559	bifunctional pantoate ligase/cytidylate kinase; Provisional; Region: PRK13477
59920004560	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
59920004561	active site
59920004562	nucleotide binding site [chemical binding]; other site
59920004563	HIGH motif; other site
59920004564	KMSKS motif; other site
59920004565	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
59920004566	CMP-binding site; other site
59920004567	The sites determining sugar specificity; other site
59920004568	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
59920004569	Low molecular weight phosphatase family; Region: LMWPc; cd00115
59920004570	active site
59920004571	phycoerythrobilin:ferredoxin oxidoreductase; Provisional; Region: PRK13249
59920004572	dihydrobiliverdin:ferredoxin oxidoreductase; Provisional; Region: PRK13247
59920004573	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
59920004574	heme binding pocket [chemical binding]; other site
59920004575	heme ligand [chemical binding]; other site
59920004576	isocitrate dehydrogenase; Validated; Region: PRK07362
59920004577	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
59920004578	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
59920004579	Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304
59920004580	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
59920004581	phosphate binding site [ion binding]; other site
59920004582	Aldose 1-epimerase, similar to Synechocystis Slr1438; Region: Aldose_epim_Slr1438; cd09025
59920004583	active site
59920004584	catalytic residues [active]
59920004585	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
59920004586	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
59920004587	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
59920004588	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
59920004589	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
59920004590	homodimer interface [polypeptide binding]; other site
59920004591	active site pocket [active]
59920004592	ribonuclease III, bacterial; Region: RNaseIII; TIGR02191
59920004593	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
59920004594	dimerization interface [polypeptide binding]; other site
59920004595	active site
59920004596	metal binding site [ion binding]; metal-binding site
59920004597	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
59920004598	dsRNA binding site [nucleotide binding]; other site
59920004599	Protein of unknown function (DUF3252); Region: DUF3252; pfam11623
59920004600	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
59920004601	RimM N-terminal domain; Region: RimM; pfam01782
59920004602	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
59920004603	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
59920004604	Substrate binding site; other site
59920004605	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
59920004606	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
59920004607	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
59920004608	glutaminase active site [active]
59920004609	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
59920004610	dimer interface [polypeptide binding]; other site
59920004611	active site
59920004612	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
59920004613	dimer interface [polypeptide binding]; other site
59920004614	active site
59920004615	photosystem I subunit VII; Region: psaC; CHL00065
59920004616	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
59920004617	acyl carrier protein; Provisional; Region: acpP; PRK00982
59920004618	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
59920004619	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
59920004620	dimer interface [polypeptide binding]; other site
59920004621	active site
59920004622	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
59920004623	transketolase; Region: PLN02790
59920004624	TPP-binding site [chemical binding]; other site
59920004625	dimer interface [polypeptide binding]; other site
59920004626	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
59920004627	PYR/PP interface [polypeptide binding]; other site
59920004628	dimer interface [polypeptide binding]; other site
59920004629	TPP binding site [chemical binding]; other site
59920004630	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
59920004631	thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352
59920004632	thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190
59920004633	Protein of unknown function (DUF3188); Region: DUF3188; pfam11384
59920004634	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
59920004635	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
59920004636	metal binding site [ion binding]; metal-binding site
59920004637	dimer interface [polypeptide binding]; other site
59920004638	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
59920004639	binding surface
59920004640	TPR motif; other site
59920004641	TPR repeat; Region: TPR_11; pfam13414
59920004642	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
59920004643	binding surface
59920004644	TPR motif; other site
59920004645	TPR repeat; Region: TPR_11; pfam13414
59920004646	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
59920004647	binding surface
59920004648	TPR motif; other site
59920004649	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
59920004650	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
59920004651	Walker A motif; other site
59920004652	ATP binding site [chemical binding]; other site
59920004653	Walker B motif; other site
59920004654	arginine finger; other site
59920004655	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
59920004656	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
59920004657	SmpB-tmRNA interface; other site
59920004658	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
59920004659	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
59920004660	dimer interface [polypeptide binding]; other site
59920004661	putative anticodon binding site; other site
59920004662	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
59920004663	motif 1; other site
59920004664	active site
59920004665	motif 2; other site
59920004666	motif 3; other site
59920004667	Ycf27; Reviewed; Region: orf27; CHL00148
59920004668	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
59920004669	active site
59920004670	phosphorylation site [posttranslational modification]
59920004671	intermolecular recognition site; other site
59920004672	dimerization interface [polypeptide binding]; other site
59920004673	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
59920004674	DNA binding site [nucleotide binding]
59920004675	rod shape-determining protein MreC; Provisional; Region: PRK13922
59920004676	rod shape-determining protein MreC; Region: MreC; pfam04085
59920004677	rod shape-determining protein MreB; Provisional; Region: PRK13927
59920004678	MreB and similar proteins; Region: MreB_like; cd10225
59920004679	nucleotide binding site [chemical binding]; other site
59920004680	Mg binding site [ion binding]; other site
59920004681	putative protofilament interaction site [polypeptide binding]; other site
59920004682	RodZ interaction site [polypeptide binding]; other site
59920004683	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
59920004684	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
59920004685	dimer interface [polypeptide binding]; other site
59920004686	ssDNA binding site [nucleotide binding]; other site
59920004687	tetramer (dimer of dimers) interface [polypeptide binding]; other site
59920004688	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
59920004689	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
59920004690	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
59920004691	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
59920004692	homotetramer interface [polypeptide binding]; other site
59920004693	ligand binding site [chemical binding]; other site
59920004694	catalytic site [active]
59920004695	NAD binding site [chemical binding]; other site
59920004696	Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; pfam02367
59920004697	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
59920004698	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
59920004699	putative substrate binding site [chemical binding]; other site
59920004700	putative ATP binding site [chemical binding]; other site
59920004701	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
59920004702	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
59920004703	minor groove reading motif; other site
59920004704	helix-hairpin-helix signature motif; other site
59920004705	substrate binding pocket [chemical binding]; other site
59920004706	active site
59920004707	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
59920004708	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
59920004709	active site
59920004710	8-oxo-dGMP binding site [chemical binding]; other site
59920004711	nudix motif; other site
59920004712	metal binding site [ion binding]; metal-binding site
59920004713	hydrolase, alpha/beta fold family protein; Region: PLN02824
59920004714	putative hydrolase; Provisional; Region: PRK11460
59920004715	RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997
59920004716	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
59920004717	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
59920004718	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
59920004719	Sigma-70, region 4; Region: Sigma70_r4; pfam04545
59920004720	Mg2+ transporter (mgtE); Region: mgtE; TIGR00400
59920004721	MgtE intracellular N domain; Region: MgtE_N; smart00924
59920004722	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
59920004723	Divalent cation transporter; Region: MgtE; pfam01769
59920004724	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
59920004725	catalytic residues [active]
59920004726	dimer interface [polypeptide binding]; other site
59920004727	CrcB-like protein; Region: CRCB; pfam02537
59920004728	CrcB-like protein; Region: CRCB; pfam02537
59920004729	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
59920004730	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
59920004731	ATP binding site [chemical binding]; other site
59920004732	Mg2+ binding site [ion binding]; other site
59920004733	G-X-G motif; other site
59920004734	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
59920004735	anchoring element; other site
59920004736	dimer interface [polypeptide binding]; other site
59920004737	ATP binding site [chemical binding]; other site
59920004738	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
59920004739	active site
59920004740	putative metal-binding site [ion binding]; other site
59920004741	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
59920004742	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
59920004743	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
59920004744	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
59920004745	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
59920004746	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
59920004747	Predicted transcriptional regulators [Transcription]; Region: COG1725
59920004748	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
59920004749	DNA-binding site [nucleotide binding]; DNA binding site
59920004750	serine O-acetyltransferase; Region: cysE; TIGR01172
59920004751	Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762
59920004752	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
59920004753	trimer interface [polypeptide binding]; other site
59920004754	active site
59920004755	substrate binding site [chemical binding]; other site
59920004756	CoA binding site [chemical binding]; other site
59920004757	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
59920004758	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
59920004759	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
59920004760	Walker A/P-loop; other site
59920004761	ATP binding site [chemical binding]; other site
59920004762	Q-loop/lid; other site
59920004763	ABC transporter signature motif; other site
59920004764	Walker B; other site
59920004765	D-loop; other site
59920004766	H-loop/switch region; other site
59920004767	preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12902
59920004768	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
59920004769	ATP binding site [chemical binding]; other site
59920004770	putative Mg++ binding site [ion binding]; other site
59920004771	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
59920004772	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
59920004773	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
59920004774	NADP-binding site; other site
59920004775	homotetramer interface [polypeptide binding]; other site
59920004776	substrate binding site [chemical binding]; other site
59920004777	homodimer interface [polypeptide binding]; other site
59920004778	active site
59920004779	Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277
59920004780	active site
59920004781	Domain of unknown function (DUF4214); Region: DUF4214; pfam13946
59920004782	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
59920004783	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
59920004784	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
59920004785	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259
59920004786	putative active site [active]
59920004787	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
59920004788	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
59920004789	Walker A/P-loop; other site
59920004790	ATP binding site [chemical binding]; other site
59920004791	Q-loop/lid; other site
59920004792	ABC transporter signature motif; other site
59920004793	Walker B; other site
59920004794	D-loop; other site
59920004795	H-loop/switch region; other site
59920004796	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
59920004797	HlyD family secretion protein; Region: HlyD_3; pfam13437
59920004798	Domain of unknown function (DUF4214); Region: DUF4214; pfam13946
59920004799	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
59920004800	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
59920004801	NADP-binding site; other site
59920004802	homotetramer interface [polypeptide binding]; other site
59920004803	substrate binding site [chemical binding]; other site
59920004804	homodimer interface [polypeptide binding]; other site
59920004805	active site
59920004806	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
59920004807	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
59920004808	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
59920004809	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
59920004810	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
59920004811	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
59920004812	Methyltransferase domain; Region: Methyltransf_23; pfam13489
59920004813	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
59920004814	S-adenosylmethionine binding site [chemical binding]; other site
59920004815	type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521
59920004816	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
59920004817	binding surface
59920004818	TPR motif; other site
59920004819	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
59920004820	binding surface
59920004821	TPR motif; other site
59920004822	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
59920004823	binding surface
59920004824	TPR motif; other site
59920004825	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
59920004826	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
59920004827	binding surface
59920004828	TPR motif; other site
59920004829	TPR repeat; Region: TPR_11; pfam13414
59920004830	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
59920004831	binding surface
59920004832	TPR motif; other site
59920004833	TPR repeat; Region: TPR_11; pfam13414
59920004834	TPR repeat; Region: TPR_11; pfam13414
59920004835	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
59920004836	binding surface
59920004837	TPR motif; other site
59920004838	TPR repeat; Region: TPR_11; pfam13414
59920004839	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
59920004840	binding surface
59920004841	TPR motif; other site
59920004842	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
59920004843	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
59920004844	binding surface
59920004845	TPR motif; other site
59920004846	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
59920004847	NAD(P) binding site [chemical binding]; other site
59920004848	active site
59920004849	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
59920004850	UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589
59920004851	NAD(P) binding site [chemical binding]; other site
59920004852	homodimer interface [polypeptide binding]; other site
59920004853	substrate binding site [chemical binding]; other site
59920004854	active site
59920004855	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
59920004856	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
59920004857	NAD binding site [chemical binding]; other site
59920004858	substrate binding site [chemical binding]; other site
59920004859	homodimer interface [polypeptide binding]; other site
59920004860	active site
59920004861	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
59920004862	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
59920004863	active site
59920004864	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
59920004865	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
59920004866	NADP binding site [chemical binding]; other site
59920004867	active site
59920004868	putative substrate binding site [chemical binding]; other site
59920004869	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
59920004870	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
59920004871	homopentamer interface [polypeptide binding]; other site
59920004872	active site
59920004873	photosystem II core protein PsbZ; Region: PS_II_psbZ; TIGR03043
59920004874	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
59920004875	MutS domain I; Region: MutS_I; pfam01624
59920004876	MutS domain II; Region: MutS_II; pfam05188
59920004877	MutS domain III; Region: MutS_III; pfam05192
59920004878	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
59920004879	Walker A/P-loop; other site
59920004880	ATP binding site [chemical binding]; other site
59920004881	Q-loop/lid; other site
59920004882	ABC transporter signature motif; other site
59920004883	Walker B; other site
59920004884	D-loop; other site
59920004885	H-loop/switch region; other site
59920004886	cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913
59920004887	Precorrin-8X methylmutase; Region: CbiC; pfam02570
59920004888	DNA polymerase III subunit delta; Validated; Region: PRK07452
59920004889	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
59920004890	aspartate kinase; Provisional; Region: PRK07431
59920004891	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
59920004892	putative nucleotide binding site [chemical binding]; other site
59920004893	putative catalytic residues [active]
59920004894	putative Mg ion binding site [ion binding]; other site
59920004895	putative aspartate binding site [chemical binding]; other site
59920004896	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
59920004897	putative allosteric regulatory site; other site
59920004898	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
59920004899	putative allosteric regulatory residue; other site
59920004900	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
59920004901	putative allosteric regulatory site; other site
59920004902	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
59920004903	excinuclease ABC subunit B; Provisional; Region: PRK05298
59920004904	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
59920004905	ATP binding site [chemical binding]; other site
59920004906	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
59920004907	nucleotide binding region [chemical binding]; other site
59920004908	ATP-binding site [chemical binding]; other site
59920004909	Ultra-violet resistance protein B; Region: UvrB; pfam12344
59920004910	UvrB/uvrC motif; Region: UVR; pfam02151
59920004911	Protein of unknown function (DUF561); Region: DUF561; pfam04481
59920004912	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
59920004913	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
59920004914	Ligand Binding Site [chemical binding]; other site
59920004915	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
59920004916	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
59920004917	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
59920004918	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
59920004919	dihydrodipicolinate synthase; Region: dapA; TIGR00674
59920004920	dimer interface [polypeptide binding]; other site
59920004921	active site
59920004922	catalytic residue [active]
59920004923	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
59920004924	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
59920004925	trigger factor; Provisional; Region: tig; PRK01490
59920004926	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
59920004927	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
59920004928	Clp protease; Region: CLP_protease; pfam00574
59920004929	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
59920004930	oligomer interface [polypeptide binding]; other site
59920004931	active site residues [active]
59920004932	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
59920004933	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
59920004934	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
59920004935	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
59920004936	Walker A motif; other site
59920004937	ATP binding site [chemical binding]; other site
59920004938	Walker B motif; other site
59920004939	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
59920004940	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14948
59920004941	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
59920004942	Walker A motif; other site
59920004943	ATP binding site [chemical binding]; other site
59920004944	Walker B motif; other site
59920004945	arginine finger; other site
59920004946	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
59920004947	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
59920004948	DXD motif; other site
59920004949	Sporulation related domain; Region: SPOR; cl10051
59920004950	Stage II sporulation protein; Region: SpoIID; pfam08486
59920004951	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
59920004952	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
59920004953	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
59920004954	23S rRNA binding site [nucleotide binding]; other site
59920004955	L21 binding site [polypeptide binding]; other site
59920004956	L13 binding site [polypeptide binding]; other site
59920004957	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
59920004958	binding surface
59920004959	TPR motif; other site
59920004960	TPR repeat; Region: TPR_11; pfam13414
59920004961	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
59920004962	ThiS interaction site; other site
59920004963	putative active site [active]
59920004964	tetramer interface [polypeptide binding]; other site
59920004965	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
59920004966	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
59920004967	NAD(P) binding site [chemical binding]; other site
59920004968	active site
59920004969	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
59920004970	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
59920004971	glycine dehydrogenase; Provisional; Region: PRK05367
59920004972	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
59920004973	tetramer interface [polypeptide binding]; other site
59920004974	pyridoxal 5'-phosphate binding site [chemical binding]; other site
59920004975	catalytic residue [active]
59920004976	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
59920004977	tetramer interface [polypeptide binding]; other site
59920004978	pyridoxal 5'-phosphate binding site [chemical binding]; other site
59920004979	catalytic residue [active]
59920004980	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
59920004981	lipoyl attachment site [posttranslational modification]; other site
59920004982	Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100
59920004983	Aluminium resistance protein; Region: Alum_res; pfam06838
59920004984	Fatty acid desaturase; Region: FA_desaturase; pfam00487
59920004985	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
59920004986	Di-iron ligands [ion binding]; other site
59920004987	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
59920004988	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
59920004989	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
59920004990	replicative DNA helicase; Region: DnaB; TIGR00665
59920004991	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
59920004992	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
59920004993	Walker A motif; other site
59920004994	ATP binding site [chemical binding]; other site
59920004995	Walker B motif; other site
59920004996	DNA binding loops [nucleotide binding]
59920004997	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
59920004998	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
59920004999	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
59920005000	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
59920005001	Protein of unknown function (DUF98); Region: DUF98; pfam01947
59920005002	SprT-like family; Region: SprT-like; pfam10263
59920005003	SprT homologues; Region: SprT; cl01182
59920005004	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
59920005005	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
59920005006	nucleotide binding pocket [chemical binding]; other site
59920005007	K-X-D-G motif; other site
59920005008	catalytic site [active]
59920005009	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
59920005010	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
59920005011	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
59920005012	Dimer interface [polypeptide binding]; other site
59920005013	BRCT sequence motif; other site
59920005014	Uncharacterized conserved protein [Function unknown]; Region: COG0398
59920005015	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
59920005016	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
59920005017	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
59920005018	active site
59920005019	HIGH motif; other site
59920005020	nucleotide binding site [chemical binding]; other site
59920005021	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
59920005022	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
59920005023	active site
59920005024	KMSKS motif; other site
59920005025	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
59920005026	tRNA binding surface [nucleotide binding]; other site
59920005027	anticodon binding site; other site
59920005028	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
59920005029	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
59920005030	homodimer interface [polypeptide binding]; other site
59920005031	MazG family protein; Region: mazG; TIGR00444
59920005032	metal binding site [ion binding]; metal-binding site
59920005033	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
59920005034	homodimer interface [polypeptide binding]; other site
59920005035	active site
59920005036	putative chemical substrate binding site [chemical binding]; other site
59920005037	metal binding site [ion binding]; metal-binding site
59920005038	spermidine synthase; Provisional; Region: PRK00811
59920005039	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
59920005040	S-adenosylmethionine binding site [chemical binding]; other site
59920005041	agmatinase; Region: agmatinase; TIGR01230
59920005042	Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593
59920005043	putative active site [active]
59920005044	Mn binding site [ion binding]; other site
59920005045	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
59920005046	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
59920005047	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
59920005048	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
59920005049	dimer interface [polypeptide binding]; other site
59920005050	anticodon binding site; other site
59920005051	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
59920005052	homodimer interface [polypeptide binding]; other site
59920005053	motif 1; other site
59920005054	active site
59920005055	motif 2; other site
59920005056	GAD domain; Region: GAD; pfam02938
59920005057	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
59920005058	active site
59920005059	motif 3; other site
59920005060	CTP synthetase; Validated; Region: pyrG; PRK05380
59920005061	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
59920005062	Catalytic site [active]
59920005063	active site
59920005064	UTP binding site [chemical binding]; other site
59920005065	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
59920005066	active site
59920005067	putative oxyanion hole; other site
59920005068	catalytic triad [active]
59920005069	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
59920005070	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322
59920005071	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
59920005072	Ligand Binding Site [chemical binding]; other site
59920005073	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
59920005074	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
59920005075	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
59920005076	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
59920005077	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449
59920005078	homodimer interface [polypeptide binding]; other site
59920005079	substrate-cofactor binding pocket; other site
59920005080	pyridoxal 5'-phosphate binding site [chemical binding]; other site
59920005081	catalytic residue [active]
59920005082	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
59920005083	active site
59920005084	SAM binding site [chemical binding]; other site
59920005085	homodimer interface [polypeptide binding]; other site
59920005086	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
59920005087	putative active site [active]
59920005088	ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566
59920005089	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
59920005090	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
59920005091	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
59920005092	hypothetical protein; Provisional; Region: PRK07394
59920005093	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
59920005094	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
59920005095	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
59920005096	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
59920005097	Major Facilitator Superfamily; Region: MFS_1; pfam07690
59920005098	putative substrate translocation pore; other site
59920005099	polyphosphate kinase; Provisional; Region: PRK05443
59920005100	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
59920005101	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
59920005102	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
59920005103	putative domain interface [polypeptide binding]; other site
59920005104	putative active site [active]
59920005105	catalytic site [active]
59920005106	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
59920005107	putative domain interface [polypeptide binding]; other site
59920005108	putative active site [active]
59920005109	catalytic site [active]
59920005110	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
59920005111	RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997
59920005112	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
59920005113	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
59920005114	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
59920005115	DNA binding residues [nucleotide binding]
59920005116	Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170
59920005117	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
59920005118	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
59920005119	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
59920005120	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
59920005121	substrate binding site [chemical binding]; other site
59920005122	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
59920005123	substrate binding site [chemical binding]; other site
59920005124	ligand binding site [chemical binding]; other site
59920005125	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915
59920005126	dimer interface [polypeptide binding]; other site
59920005127	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
59920005128	O-Antigen ligase; Region: Wzy_C; pfam04932
59920005129	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
59920005130	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
59920005131	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
59920005132	putative active site [active]
59920005133	putative substrate binding site [chemical binding]; other site
59920005134	putative cosubstrate binding site; other site
59920005135	catalytic site [active]
59920005136	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
59920005137	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
59920005138	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
59920005139	nucleotide binding site [chemical binding]; other site
59920005140	NEF interaction site [polypeptide binding]; other site
59920005141	SBD interface [polypeptide binding]; other site
59920005142	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
59920005143	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
59920005144	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
59920005145	shikimate binding site; other site
59920005146	NAD(P) binding site [chemical binding]; other site
59920005147	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
59920005148	argininosuccinate synthase; Provisional; Region: PRK13820
59920005149	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
59920005150	ANP binding site [chemical binding]; other site
59920005151	Substrate Binding Site II [chemical binding]; other site
59920005152	Substrate Binding Site I [chemical binding]; other site
59920005153	Protein of unknown function (DUF3134); Region: DUF3134; pfam11332
59920005154	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
59920005155	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
59920005156	Mg++ binding site [ion binding]; other site
59920005157	putative catalytic motif [active]
59920005158	putative substrate binding site [chemical binding]; other site
59920005159	sucrose-phosphate synthase, putative, glycosyltransferase domain; Region: sucr_P_syn_N; TIGR02472
59920005160	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
59920005161	putative ADP-binding pocket [chemical binding]; other site
59920005162	sucrose phosphate synthase, sucrose phosphatase-like domain, bacterial; Region: sucr_syn_bact_C; TIGR02471
59920005163	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
59920005164	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
59920005165	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
59920005166	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
59920005167	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
59920005168	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
59920005169	Walker A/P-loop; other site
59920005170	ATP binding site [chemical binding]; other site
59920005171	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
59920005172	ABC transporter signature motif; other site
59920005173	Walker B; other site
59920005174	D-loop; other site
59920005175	H-loop/switch region; other site
59920005176	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
59920005177	ABC1 family; Region: ABC1; cl17513
59920005178	Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176
59920005179	threonine synthase; Reviewed; Region: PRK06721
59920005180	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
59920005181	homodimer interface [polypeptide binding]; other site
59920005182	pyridoxal 5'-phosphate binding site [chemical binding]; other site
59920005183	catalytic residue [active]