-- dump date 20140620_000512 -- class Genbank::misc_feature -- table misc_feature_note -- id note 59919000001 DNA polymerase III subunit beta; Validated; Region: PRK05643 59919000002 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 59919000003 putative DNA binding surface [nucleotide binding]; other site 59919000004 dimer interface [polypeptide binding]; other site 59919000005 beta-clamp/clamp loader binding surface; other site 59919000006 beta-clamp/translesion DNA polymerase binding surface; other site 59919000007 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 59919000008 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 59919000009 dimerization interface [polypeptide binding]; other site 59919000010 ATP binding site [chemical binding]; other site 59919000011 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 59919000012 dimerization interface [polypeptide binding]; other site 59919000013 ATP binding site [chemical binding]; other site 59919000014 amidophosphoribosyltransferase; Provisional; Region: PRK09246 59919000015 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 59919000016 active site 59919000017 tetramer interface [polypeptide binding]; other site 59919000018 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 59919000019 active site 59919000020 DNA Topoisomerase IV; Region: TOP4c; smart00434 59919000021 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 59919000022 CAP-like domain; other site 59919000023 active site 59919000024 primary dimer interface [polypeptide binding]; other site 59919000025 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59919000026 binding surface 59919000027 TPR motif; other site 59919000028 TPR repeat; Region: TPR_11; pfam13414 59919000029 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 59919000030 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 59919000031 Uncharacterized conserved protein [Function unknown]; Region: COG2928 59919000032 2 probable transmembrane helices predicted by TMHMM2.0 59919000033 transcription antitermination protein NusB; Provisional; Region: nusB; PRK09634 59919000034 putative RNA binding site [nucleotide binding]; other site 59919000035 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 59919000036 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 59919000037 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 59919000038 P loop; other site 59919000039 GTP binding site [chemical binding]; other site 59919000040 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 59919000041 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 59919000042 argininosuccinate lyase; Provisional; Region: PRK00855 59919000043 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 59919000044 active sites [active] 59919000045 tetramer interface [polypeptide binding]; other site 59919000046 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 59919000047 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 59919000048 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 59919000049 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 59919000050 FMN binding site [chemical binding]; other site 59919000051 active site 59919000052 catalytic residues [active] 59919000053 substrate binding site [chemical binding]; other site 59919000054 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 59919000055 SelR domain; Region: SelR; pfam01641 59919000056 GrpE; Region: GrpE; pfam01025 59919000057 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 59919000058 dimer interface [polypeptide binding]; other site 59919000059 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 59919000060 chaperone protein DnaJ; Provisional; Region: PRK14293 59919000061 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 59919000062 HSP70 interaction site [polypeptide binding]; other site 59919000063 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 59919000064 substrate binding site [polypeptide binding]; other site 59919000065 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 59919000066 Zn binding sites [ion binding]; other site 59919000067 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 59919000068 dimer interface [polypeptide binding]; other site 59919000069 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 59919000070 CPxP motif; other site 59919000071 GTPase RsgA; Reviewed; Region: PRK00098 59919000072 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 59919000073 RNA binding site [nucleotide binding]; other site 59919000074 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 59919000075 GTPase/Zn-binding domain interface [polypeptide binding]; other site 59919000076 GTP/Mg2+ binding site [chemical binding]; other site 59919000077 G4 box; other site 59919000078 G5 box; other site 59919000079 G1 box; other site 59919000080 Switch I region; other site 59919000081 G2 box; other site 59919000082 G3 box; other site 59919000083 Switch II region; other site 59919000084 hypothetical protein; Validated; Region: PRK00153 59919000085 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 59919000086 FAD binding domain; Region: FAD_binding_4; pfam01565 59919000087 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 59919000088 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 59919000089 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 59919000090 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 59919000091 1 probable transmembrane helix predicted by TMHMM2.0 59919000092 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK07403 59919000093 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 59919000094 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 59919000095 thiamine monophosphate kinase; Provisional; Region: PRK05731 59919000096 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 59919000097 ATP binding site [chemical binding]; other site 59919000098 dimerization interface [polypeptide binding]; other site 59919000099 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 59919000100 active site 59919000101 1 probable transmembrane helix predicted by TMHMM2.0 59919000102 elongation factor P; Validated; Region: PRK00529 59919000103 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 59919000104 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 59919000105 RNA binding site [nucleotide binding]; other site 59919000106 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 59919000107 RNA binding site [nucleotide binding]; other site 59919000108 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 59919000109 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 59919000110 carboxyltransferase (CT) interaction site; other site 59919000111 biotinylation site [posttranslational modification]; other site 59919000112 4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK02746 59919000113 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 59919000114 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 59919000115 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 59919000116 putative NAD(P) binding site [chemical binding]; other site 59919000117 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 59919000118 active site 59919000119 1 probable transmembrane helix predicted by TMHMM2.0 59919000120 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 59919000121 4 probable transmembrane helices predicted by TMHMM2.0 59919000122 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 59919000123 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 59919000124 catalytic residue [active] 59919000125 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 59919000126 GMP synthase; Reviewed; Region: guaA; PRK00074 59919000127 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 59919000128 AMP/PPi binding site [chemical binding]; other site 59919000129 candidate oxyanion hole; other site 59919000130 catalytic triad [active] 59919000131 potential glutamine specificity residues [chemical binding]; other site 59919000132 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 59919000133 ATP Binding subdomain [chemical binding]; other site 59919000134 Ligand Binding sites [chemical binding]; other site 59919000135 Dimerization subdomain; other site 59919000136 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 59919000137 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 59919000138 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 59919000139 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 59919000140 1 probable transmembrane helix predicted by TMHMM2.0 59919000141 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 59919000142 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 59919000143 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 59919000144 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 59919000145 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 59919000146 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 59919000147 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 59919000148 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 59919000149 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 59919000150 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 59919000151 motif 1; other site 59919000152 active site 59919000153 motif 2; other site 59919000154 motif 3; other site 59919000155 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 59919000156 DHHA1 domain; Region: DHHA1; pfam02272 59919000157 arginine decarboxylase; Provisional; Region: PRK05354 59919000158 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 59919000159 dimer interface [polypeptide binding]; other site 59919000160 active site 59919000161 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 59919000162 catalytic residues [active] 59919000163 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 59919000164 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 59919000165 active site 59919000166 multimer interface [polypeptide binding]; other site 59919000167 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 59919000168 1 probable transmembrane helix predicted by TMHMM2.0 59919000169 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 59919000170 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 59919000171 GatB domain; Region: GatB_Yqey; smart00845 59919000172 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 59919000173 dephospho-CoA kinase; Region: TIGR00152 59919000174 CoA-binding site [chemical binding]; other site 59919000175 ATP-binding [chemical binding]; other site 59919000176 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 59919000177 heterotetramer interface [polypeptide binding]; other site 59919000178 active site pocket [active] 59919000179 cleavage site 59919000180 ParA-like protein; Provisional; Region: PHA02518 59919000181 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 59919000182 P-loop; other site 59919000183 Magnesium ion binding site [ion binding]; other site 59919000184 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 59919000185 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 59919000186 active site 59919000187 catalytic tetrad [active] 59919000188 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 59919000189 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 59919000190 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 59919000191 2 probable transmembrane helices predicted by TMHMM2.0 59919000192 1 probable transmembrane helix predicted by TMHMM2.0 59919000193 DNA polymerase Ligase (LigD); Region: LigD_N; pfam13298 59919000194 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 59919000195 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 59919000196 Walker A/P-loop; other site 59919000197 ATP binding site [chemical binding]; other site 59919000198 Q-loop/lid; other site 59919000199 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 59919000200 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 59919000201 ABC transporter signature motif; other site 59919000202 Walker B; other site 59919000203 D-loop; other site 59919000204 H-loop/switch region; other site 59919000205 PRC-barrel domain; Region: PRC; pfam05239 59919000206 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 59919000207 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 59919000208 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 59919000209 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 59919000210 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 59919000211 YGGT family; Region: YGGT; pfam02325 59919000212 2 probable transmembrane helices predicted by TMHMM2.0 59919000213 Ycf66 protein N-terminus; Region: Ycf66_N; pfam07444 59919000214 3 probable transmembrane helices predicted by TMHMM2.0 59919000215 Chlorophyll A-B binding protein; Region: Chloroa_b-bind; pfam00504 59919000216 1 probable transmembrane helix predicted by TMHMM2.0 59919000217 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 59919000218 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 59919000219 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 59919000220 7 probable transmembrane helices predicted by TMHMM2.0 59919000221 1 probable transmembrane helix predicted by TMHMM2.0 59919000222 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 59919000223 nucleotide binding site/active site [active] 59919000224 HIT family signature motif; other site 59919000225 catalytic residue [active] 59919000226 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 59919000227 active site 59919000228 catalytic residues [active] 59919000229 metal binding site [ion binding]; metal-binding site 59919000230 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 59919000231 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 59919000232 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 59919000233 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 59919000234 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 59919000235 catalytic residue [active] 59919000236 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 59919000237 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 59919000238 sulfate ABC transporter protein; Validated; Region: ycf16; CHL00131 59919000239 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 59919000240 Walker A/P-loop; other site 59919000241 ATP binding site [chemical binding]; other site 59919000242 Q-loop/lid; other site 59919000243 ABC transporter signature motif; other site 59919000244 Walker B; other site 59919000245 D-loop; other site 59919000246 H-loop/switch region; other site 59919000247 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 59919000248 putative ABC transporter; Region: ycf24; CHL00085 59919000249 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 59919000250 phosphoglucomutase; Region: PLN02307 59919000251 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 59919000252 active site 59919000253 substrate binding site [chemical binding]; other site 59919000254 metal binding site [ion binding]; metal-binding site 59919000255 recombination factor protein RarA; Reviewed; Region: PRK13342 59919000256 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 59919000257 Walker A motif; other site 59919000258 ATP binding site [chemical binding]; other site 59919000259 Walker B motif; other site 59919000260 arginine finger; other site 59919000261 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 59919000262 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 59919000263 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 59919000264 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 59919000265 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 59919000266 catalytic triad [active] 59919000267 Type III pantothenate kinase; Region: Pan_kinase; cl17198 59919000268 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 59919000269 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 59919000270 Active Sites [active] 59919000271 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 59919000272 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 59919000273 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 59919000274 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 59919000275 transmembrane helices; other site 59919000276 TrkA-C domain; Region: TrkA_C; pfam02080 59919000277 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 59919000278 TrkA-C domain; Region: TrkA_C; pfam02080 59919000279 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 59919000280 11 probable transmembrane helices predicted by TMHMM2.0 59919000281 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 59919000282 Cation transport protein; Region: TrkH; pfam02386 59919000283 10 probable transmembrane helices predicted by TMHMM2.0 59919000284 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 59919000285 TrkA-N domain; Region: TrkA_N; pfam02254 59919000286 TrkA-C domain; Region: TrkA_C; pfam02080 59919000287 Protein of unknown function (DUF1662); Region: DUF1662; pfam07878 59919000288 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 59919000289 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 59919000290 Walker A/P-loop; other site 59919000291 ATP binding site [chemical binding]; other site 59919000292 Q-loop/lid; other site 59919000293 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 59919000294 ABC transporter signature motif; other site 59919000295 Walker B; other site 59919000296 D-loop; other site 59919000297 ABC transporter; Region: ABC_tran_2; pfam12848 59919000298 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 59919000299 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 59919000300 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 59919000301 protein binding site [polypeptide binding]; other site 59919000302 Protein of unknown function (DUF2973); Region: DUF2973; pfam11189 59919000303 1 probable transmembrane helix predicted by TMHMM2.0 59919000304 2 probable transmembrane helices predicted by TMHMM2.0 59919000305 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 59919000306 6 probable transmembrane helices predicted by TMHMM2.0 59919000307 Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643 59919000308 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 59919000309 active site 59919000310 Outer membrane efflux protein; Region: OEP; pfam02321 59919000311 Outer membrane efflux protein; Region: OEP; pfam02321 59919000312 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 59919000313 Protein of unknown function (DUF512); Region: DUF512; pfam04459 59919000314 Protein of unknown function (DUF3120); Region: DUF3120; pfam11318 59919000315 7 probable transmembrane helices predicted by TMHMM2.0 59919000316 L-aspartate oxidase; Provisional; Region: PRK07395 59919000317 L-aspartate oxidase; Provisional; Region: PRK06175 59919000318 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 59919000319 Vitamin K epoxide reductase family in bacteria and plants; Region: VKOR_1; cd12916 59919000320 substrate binding site [chemical binding]; other site 59919000321 putative active site [active] 59919000322 redox center [active] 59919000323 Protein Disulfide Isomerase (PDIa) family, redox active TRX domains; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family include PDI...; Region: PDI_a_family; cd02961 59919000324 catalytic residues [active] 59919000325 4 probable transmembrane helices predicted by TMHMM2.0 59919000326 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 59919000327 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 59919000328 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 59919000329 FeS/SAM binding site; other site 59919000330 TRAM domain; Region: TRAM; cl01282 59919000331 Domain of unknown function (DUF4346); Region: DUF4346; pfam14251 59919000332 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 59919000333 Protein of unknown function, DUF482; Region: DUF482; pfam04339 59919000334 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 59919000335 RibD C-terminal domain; Region: RibD_C; cl17279 59919000336 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 59919000337 active site 59919000338 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 59919000339 active site 59919000340 shikimate kinase; Reviewed; Region: aroK; PRK00131 59919000341 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 59919000342 ADP binding site [chemical binding]; other site 59919000343 magnesium binding site [ion binding]; other site 59919000344 putative shikimate binding site; other site 59919000345 Protein of unknown function (DUF3571); Region: DUF3571; pfam12095 59919000346 1 probable transmembrane helix predicted by TMHMM2.0 59919000347 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 59919000348 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 59919000349 C-terminal domain interface [polypeptide binding]; other site 59919000350 GSH binding site (G-site) [chemical binding]; other site 59919000351 dimer interface [polypeptide binding]; other site 59919000352 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 59919000353 N-terminal domain interface [polypeptide binding]; other site 59919000354 dimer interface [polypeptide binding]; other site 59919000355 substrate binding pocket (H-site) [chemical binding]; other site 59919000356 Protein of unknown function (DUF751); Region: DUF751; pfam05421 59919000357 2 probable transmembrane helices predicted by TMHMM2.0 59919000358 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 59919000359 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 59919000360 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 59919000361 active site 59919000362 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 59919000363 putative hydrophobic ligand binding site [chemical binding]; other site 59919000364 9,9'-di-cis-zeta-carotene desaturase; Region: zeta_caro_desat; TIGR02732 59919000365 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 59919000366 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 59919000367 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370 59919000368 conserved hypothetical protein; Region: TIGR03492 59919000369 2 probable transmembrane helices predicted by TMHMM2.0 59919000370 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 59919000371 TIGR01777 family protein; Region: yfcH 59919000372 NAD(P) binding site [chemical binding]; other site 59919000373 active site 59919000374 Cyanobacterial and plant NDH-1 subunit O; Region: NdhO; pfam11910 59919000375 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 59919000376 HSP70 interaction site [polypeptide binding]; other site 59919000377 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 59919000378 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 59919000379 dimer interface [polypeptide binding]; other site 59919000380 pyridoxal 5'-phosphate binding site [chemical binding]; other site 59919000381 catalytic residue [active] 59919000382 hypothetical protein; Provisional; Region: PRK13683 59919000383 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 59919000384 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 59919000385 Walker A/P-loop; other site 59919000386 ATP binding site [chemical binding]; other site 59919000387 Q-loop/lid; other site 59919000388 ABC transporter signature motif; other site 59919000389 Walker B; other site 59919000390 D-loop; other site 59919000391 H-loop/switch region; other site 59919000392 Polysaccharide lyase; Region: Polysacc_lyase; pfam14099 59919000393 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 59919000394 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 59919000395 active site 59919000396 phosphorylation site [posttranslational modification] 59919000397 intermolecular recognition site; other site 59919000398 dimerization interface [polypeptide binding]; other site 59919000399 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 59919000400 DNA binding site [nucleotide binding] 59919000401 DNA polymerase III subunit delta'; Validated; Region: PRK07399 59919000402 thymidylate kinase; Validated; Region: tmk; PRK00698 59919000403 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 59919000404 TMP-binding site; other site 59919000405 ATP-binding site [chemical binding]; other site 59919000406 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 59919000407 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 59919000408 metal-binding site [ion binding] 59919000409 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 59919000410 Soluble P-type ATPase [General function prediction only]; Region: COG4087 59919000411 8 probable transmembrane helices predicted by TMHMM2.0 59919000412 photosystem I assembly protein Ycf3; Provisional; Region: PRK02603 59919000413 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59919000414 binding surface 59919000415 TPR motif; other site 59919000416 DNA repair protein RadA; Provisional; Region: PRK11823 59919000417 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 59919000418 Walker A motif; other site 59919000419 ATP binding site [chemical binding]; other site 59919000420 Walker B motif; other site 59919000421 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 59919000422 Ycf27; Reviewed; Region: orf27; CHL00148 59919000423 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 59919000424 active site 59919000425 phosphorylation site [posttranslational modification] 59919000426 intermolecular recognition site; other site 59919000427 dimerization interface [polypeptide binding]; other site 59919000428 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 59919000429 DNA binding site [nucleotide binding] 59919000430 Fatty acid synthesis protein; Region: FA_synthesis; cl17261 59919000431 putative glycerol-3-phosphate acyltransferase PlsX; Provisional; Region: PRK13845 59919000432 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 59919000433 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 59919000434 dimer interface [polypeptide binding]; other site 59919000435 active site 59919000436 CoA binding pocket [chemical binding]; other site 59919000437 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 59919000438 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 59919000439 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 59919000440 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 59919000441 putative acyl-acceptor binding pocket; other site 59919000442 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 59919000443 Hypothetical chloroplast protein Ycf34; Region: Ycf34; pfam10718 59919000444 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 59919000445 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 59919000446 active site 59919000447 NTP binding site [chemical binding]; other site 59919000448 metal binding triad [ion binding]; metal-binding site 59919000449 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 59919000450 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 59919000451 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 59919000452 active site lid residues [active] 59919000453 substrate binding pocket [chemical binding]; other site 59919000454 catalytic residues [active] 59919000455 substrate-Mg2+ binding site; other site 59919000456 aspartate-rich region 1; other site 59919000457 aspartate-rich region 2; other site 59919000458 phytoene desaturase; Region: phytoene_desat; TIGR02731 59919000459 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 59919000460 Cyanobacterial and plastid NDH-1 subunit M; Region: NdhM; pfam10664 59919000461 Protein of unknown function (DUF3172); Region: DUF3172; pfam11371 59919000462 1 probable transmembrane helix predicted by TMHMM2.0 59919000463 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 59919000464 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 59919000465 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 59919000466 putative dimerization interface [polypeptide binding]; other site 59919000467 NnrU protein; Region: NnrU; cl17713 59919000468 5 probable transmembrane helices predicted by TMHMM2.0 59919000469 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07376 59919000470 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 59919000471 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 59919000472 NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010 59919000473 14 probable transmembrane helices predicted by TMHMM2.0 59919000474 NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK02546 59919000475 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 59919000476 14 probable transmembrane helices predicted by TMHMM2.0 59919000477 ScpA/B protein; Region: ScpA_ScpB; cl00598 59919000478 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 59919000479 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 59919000480 active site 59919000481 Substrate binding site; other site 59919000482 Mg++ binding site; other site 59919000483 Left-handed parallel beta-Helix (LbH) domain of a group of proteins with similarity to glucose-1-phosphate adenylyltransferase: Included in this family are glucose-1-phosphate adenylyltransferase, mannose-1-phosphate guanylyltransferase, and the...; Region: LbH_G1P_AT_C_like; cd03356 59919000484 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 59919000485 FAD binding site [chemical binding]; other site 59919000486 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 59919000487 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 59919000488 DNA binding residues [nucleotide binding] 59919000489 dimerization interface [polypeptide binding]; other site 59919000490 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 59919000491 putative active site [active] 59919000492 putative metal binding residues [ion binding]; other site 59919000493 signature motif; other site 59919000494 putative dimer interface [polypeptide binding]; other site 59919000495 putative phosphate binding site [ion binding]; other site 59919000496 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02645 59919000497 ATP-NAD kinase; Region: NAD_kinase; pfam01513 59919000498 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 59919000499 3 probable transmembrane helices predicted by TMHMM2.0 59919000500 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 59919000501 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 59919000502 5 probable transmembrane helices predicted by TMHMM2.0 59919000503 NADH-plastoquinone oxidoreductase subunit I protein; Region: ndhI; TIGR00403 59919000504 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 59919000505 NADH dehydrogenase; Region: NADHdh; cl00469 59919000506 6 probable transmembrane helices predicted by TMHMM2.0 59919000507 citrate synthase; Provisional; Region: PRK14036 59919000508 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 59919000509 oxalacetate binding site [chemical binding]; other site 59919000510 citrylCoA binding site [chemical binding]; other site 59919000511 coenzyme A binding site [chemical binding]; other site 59919000512 catalytic triad [active] 59919000513 Member of the Rhodanese Homology Domain superfamily, subgroup 2. Subgroup 2 includes uncharacterized putative rhodanese-related domains; Region: RHOD_2; cd01528 59919000514 active site residue [active] 59919000515 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 59919000516 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 59919000517 pyridoxal 5'-phosphate binding site [chemical binding]; other site 59919000518 catalytic residue [active] 59919000519 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 59919000520 putative rRNA binding site [nucleotide binding]; other site 59919000521 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 59919000522 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 59919000523 Walker A/P-loop; other site 59919000524 ligand-binding site [chemical binding]; other site 59919000525 ATP binding site [chemical binding]; other site 59919000526 AIR carboxylase; Region: AIRC; pfam00731 59919000527 Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580 59919000528 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 59919000529 S-adenosylmethionine binding site [chemical binding]; other site 59919000530 Magnesium-protoporphyrin IX methyltransferase C-terminus; Region: Mg-por_mtran_C; pfam07109 59919000531 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 59919000532 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 59919000533 active site 59919000534 phosphorylation site [posttranslational modification] 59919000535 intermolecular recognition site; other site 59919000536 dimerization interface [polypeptide binding]; other site 59919000537 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 59919000538 DNA binding residues [nucleotide binding] 59919000539 dimerization interface [polypeptide binding]; other site 59919000540 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 59919000541 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 59919000542 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 59919000543 catalytic residue [active] 59919000544 MraW methylase family; Region: Methyltransf_5; cl17771 59919000545 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 59919000546 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 59919000547 NAD(P)H-quinone oxidoreductase subunit H; Validated; Region: PRK07415 59919000548 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 59919000549 active site 59919000550 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 59919000551 acyl-activating enzyme (AAE) consensus motif; other site 59919000552 active site 59919000553 AMP binding site [chemical binding]; other site 59919000554 CoA binding site [chemical binding]; other site 59919000555 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 59919000556 active site 59919000557 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK07419 59919000558 UbiA prenyltransferase family; Region: UbiA; pfam01040 59919000559 8 probable transmembrane helices predicted by TMHMM2.0 59919000560 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 59919000561 glutathione synthetase; Provisional; Region: PRK05246 59919000562 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 59919000563 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 59919000564 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 59919000565 GSH binding site [chemical binding]; other site 59919000566 catalytic residues [active] 59919000567 peptide chain release factor 2; Validated; Region: prfB; PRK00578 59919000568 This domain is found in peptide chain release factors; Region: PCRF; smart00937 59919000569 RF-1 domain; Region: RF-1; pfam00472 59919000570 Protein of unknown function (DUF3285); Region: DUF3285; pfam11688 59919000571 1 probable transmembrane helix predicted by TMHMM2.0 59919000572 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 59919000573 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 59919000574 3 probable transmembrane helices predicted by TMHMM2.0 59919000575 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 59919000576 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 59919000577 glutamine binding [chemical binding]; other site 59919000578 catalytic triad [active] 59919000579 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 59919000580 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 59919000581 1 probable transmembrane helix predicted by TMHMM2.0 59919000582 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 59919000583 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 59919000584 pyridoxal 5'-phosphate binding site [chemical binding]; other site 59919000585 homodimer interface [polypeptide binding]; other site 59919000586 catalytic residue [active] 59919000587 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 59919000588 arginine-tRNA ligase; Region: PLN02286 59919000589 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 59919000590 active site 59919000591 HIGH motif; other site 59919000592 KMSK motif region; other site 59919000593 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 59919000594 tRNA binding surface [nucleotide binding]; other site 59919000595 anticodon binding site; other site 59919000596 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 59919000597 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 59919000598 dimerization interface [polypeptide binding]; other site 59919000599 active site 59919000600 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 59919000601 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 59919000602 trmE is a tRNA modification GTPase; Region: trmE; cd04164 59919000603 G1 box; other site 59919000604 GTP/Mg2+ binding site [chemical binding]; other site 59919000605 Switch I region; other site 59919000606 G2 box; other site 59919000607 Switch II region; other site 59919000608 G3 box; other site 59919000609 G4 box; other site 59919000610 G5 box; other site 59919000611 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 59919000612 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 59919000613 3 probable transmembrane helices predicted by TMHMM2.0 59919000614 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 59919000615 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 59919000616 Zn2+ binding site [ion binding]; other site 59919000617 Mg2+ binding site [ion binding]; other site 59919000618 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 59919000619 synthetase active site [active] 59919000620 NTP binding site [chemical binding]; other site 59919000621 metal binding site [ion binding]; metal-binding site 59919000622 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 59919000623 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 59919000624 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 59919000625 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 59919000626 Walker A/P-loop; other site 59919000627 ATP binding site [chemical binding]; other site 59919000628 Q-loop/lid; other site 59919000629 ABC transporter signature motif; other site 59919000630 Walker B; other site 59919000631 D-loop; other site 59919000632 H-loop/switch region; other site 59919000633 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 59919000634 Walker A/P-loop; other site 59919000635 ATP binding site [chemical binding]; other site 59919000636 Q-loop/lid; other site 59919000637 ABC transporter signature motif; other site 59919000638 Walker B; other site 59919000639 D-loop; other site 59919000640 H-loop/switch region; other site 59919000641 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 59919000642 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 59919000643 RNA binding surface [nucleotide binding]; other site 59919000644 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 59919000645 active site 59919000646 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 59919000647 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 59919000648 GTP/Mg2+ binding site [chemical binding]; other site 59919000649 G4 box; other site 59919000650 G5 box; other site 59919000651 G1 box; other site 59919000652 Switch I region; other site 59919000653 G2 box; other site 59919000654 G3 box; other site 59919000655 Switch II region; other site 59919000656 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 59919000657 Phosphoglycerate kinase; Region: PGK; pfam00162 59919000658 substrate binding site [chemical binding]; other site 59919000659 hinge regions; other site 59919000660 ADP binding site [chemical binding]; other site 59919000661 catalytic site [active] 59919000662 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 59919000663 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 59919000664 active site 59919000665 homodimer interface [polypeptide binding]; other site 59919000666 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 59919000667 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 59919000668 pyridoxal 5'-phosphate binding site [chemical binding]; other site 59919000669 homodimer interface [polypeptide binding]; other site 59919000670 catalytic residue [active] 59919000671 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 59919000672 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 59919000673 active site 59919000674 catalytic residues [active] 59919000675 FMN binding site [chemical binding]; other site 59919000676 quinone interaction residues [chemical binding]; other site 59919000677 substrate binding site [chemical binding]; other site 59919000678 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 59919000679 RNA/DNA hybrid binding site [nucleotide binding]; other site 59919000680 active site 59919000681 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 59919000682 L11 interface [polypeptide binding]; other site 59919000683 putative EF-Tu interaction site [polypeptide binding]; other site 59919000684 putative EF-G interaction site [polypeptide binding]; other site 59919000685 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 59919000686 23S rRNA interface [nucleotide binding]; other site 59919000687 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 59919000688 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 59919000689 mRNA/rRNA interface [nucleotide binding]; other site 59919000690 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 59919000691 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 59919000692 23S rRNA interface [nucleotide binding]; other site 59919000693 L7/L12 interface [polypeptide binding]; other site 59919000694 putative thiostrepton binding site; other site 59919000695 L25 interface [polypeptide binding]; other site 59919000696 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 59919000697 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 59919000698 putative homodimer interface [polypeptide binding]; other site 59919000699 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 59919000700 heterodimer interface [polypeptide binding]; other site 59919000701 homodimer interface [polypeptide binding]; other site 59919000702 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 59919000703 1 probable transmembrane helix predicted by TMHMM2.0 59919000704 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 59919000705 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 59919000706 Walker A motif; other site 59919000707 ATP binding site [chemical binding]; other site 59919000708 Walker B motif; other site 59919000709 arginine finger; other site 59919000710 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 59919000711 Walker A motif; other site 59919000712 ATP binding site [chemical binding]; other site 59919000713 Walker B motif; other site 59919000714 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 59919000715 enolase; Provisional; Region: eno; PRK00077 59919000716 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 59919000717 dimer interface [polypeptide binding]; other site 59919000718 metal binding site [ion binding]; metal-binding site 59919000719 substrate binding pocket [chemical binding]; other site 59919000720 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 59919000721 ABC1 family; Region: ABC1; pfam03109 59919000722 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 59919000723 active site 59919000724 ATP binding site [chemical binding]; other site 59919000725 1 probable transmembrane helix predicted by TMHMM2.0 59919000726 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 59919000727 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 59919000728 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 59919000729 Nitrogen regulatory protein P-II; Region: P-II; cl00412 59919000730 Domain of unknown function (DUF897); Region: DUF897; pfam05982 59919000731 10 probable transmembrane helices predicted by TMHMM2.0 59919000732 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 59919000733 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 59919000734 Sulfate transporter family; Region: Sulfate_transp; pfam00916 59919000735 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 59919000736 12 probable transmembrane helices predicted by TMHMM2.0 59919000737 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 59919000738 dimer interface [polypeptide binding]; other site 59919000739 allosteric magnesium binding site [ion binding]; other site 59919000740 active site 59919000741 aspartate-rich active site metal binding site; other site 59919000742 Schiff base residues; other site 59919000743 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 59919000744 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 59919000745 active site 59919000746 metal binding site [ion binding]; metal-binding site 59919000747 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 59919000748 MutS domain III; Region: MutS_III; pfam05192 59919000749 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 59919000750 Walker A/P-loop; other site 59919000751 ATP binding site [chemical binding]; other site 59919000752 Q-loop/lid; other site 59919000753 ABC transporter signature motif; other site 59919000754 Walker B; other site 59919000755 D-loop; other site 59919000756 H-loop/switch region; other site 59919000757 Smr domain; Region: Smr; cl02619 59919000758 GTPase CgtA; Reviewed; Region: obgE; PRK12299 59919000759 GTP1/OBG; Region: GTP1_OBG; pfam01018 59919000760 Obg GTPase; Region: Obg; cd01898 59919000761 G1 box; other site 59919000762 GTP/Mg2+ binding site [chemical binding]; other site 59919000763 Switch I region; other site 59919000764 G2 box; other site 59919000765 G3 box; other site 59919000766 Switch II region; other site 59919000767 G4 box; other site 59919000768 G5 box; other site 59919000769 CP12 domain; Region: CP12; pfam02672 59919000770 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 59919000771 putative dimer interface [polypeptide binding]; other site 59919000772 N-terminal domain interface [polypeptide binding]; other site 59919000773 putative substrate binding pocket (H-site) [chemical binding]; other site 59919000774 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 59919000775 Peptidase M14 Aspartoacylase (ASPA) subfamily; Region: M14_ASPA; cd06909 59919000776 active site 59919000777 Zn binding site [ion binding]; other site 59919000778 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 59919000779 protein I interface; other site 59919000780 D2 interface; other site 59919000781 protein T interface; other site 59919000782 chlorophyll binding site; other site 59919000783 beta carotene binding site; other site 59919000784 pheophytin binding site; other site 59919000785 manganese-stabilizing polypeptide interface; other site 59919000786 CP43 interface; other site 59919000787 protein L interface; other site 59919000788 oxygen evolving complex binding site; other site 59919000789 bromide binding site; other site 59919000790 quinone binding site; other site 59919000791 Fe binding site [ion binding]; other site 59919000792 core light harvesting interface; other site 59919000793 cytochrome b559 alpha subunit interface; other site 59919000794 cytochrome c-550 interface; other site 59919000795 protein J interface; other site 59919000796 5 probable transmembrane helices predicted by TMHMM2.0 59919000797 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 59919000798 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 59919000799 Tetramer interface [polypeptide binding]; other site 59919000800 active site 59919000801 FMN-binding site [chemical binding]; other site 59919000802 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 59919000803 active site 59919000804 intersubunit interface [polypeptide binding]; other site 59919000805 catalytic residue [active] 59919000806 FtsH Extracellular; Region: FtsH_ext; pfam06480 59919000807 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 59919000808 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 59919000809 Walker A motif; other site 59919000810 ATP binding site [chemical binding]; other site 59919000811 Walker B motif; other site 59919000812 arginine finger; other site 59919000813 Peptidase family M41; Region: Peptidase_M41; pfam01434 59919000814 1 probable transmembrane helix predicted by TMHMM2.0 59919000815 ATP-sulfurylase; Region: ATPS; cd00517 59919000816 ATP sulphurylase; Region: sopT; TIGR00339 59919000817 active site 59919000818 HXXH motif; other site 59919000819 flexible loop; other site 59919000820 Manganese-stabilising protein / photosystem II polypeptide; Region: MSP; cl03326 59919000821 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 59919000822 Flavoprotein; Region: Flavoprotein; pfam02441 59919000823 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 59919000824 Protein of unknown function (DUF2555); Region: DUF2555; pfam10742 59919000825 3 probable transmembrane helices predicted by TMHMM2.0 59919000826 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 59919000827 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 59919000828 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 59919000829 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 59919000830 active site 59919000831 DNA binding site [nucleotide binding] 59919000832 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 59919000834 3 probable transmembrane helices predicted by TMHMM2.0 59919000835 1 probable transmembrane helix predicted by TMHMM2.0 59919000836 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 59919000837 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 59919000838 active site 59919000839 HIGH motif; other site 59919000840 nucleotide binding site [chemical binding]; other site 59919000841 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 59919000842 active site 59919000843 KMSKS motif; other site 59919000844 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 59919000845 tRNA binding surface [nucleotide binding]; other site 59919000846 anticodon binding site; other site 59919000847 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 59919000848 Protein of unknown function (DUF3177); Region: DUF3177; pfam11375 59919000849 5 probable transmembrane helices predicted by TMHMM2.0 59919000850 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 59919000851 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14317 59919000852 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 59919000853 active site 59919000854 substrate binding site [chemical binding]; other site 59919000855 metal binding site [ion binding]; metal-binding site 59919000856 TRX-like protein A (TxlA) family; TxlA was originally isolated from the cyanobacterium Synechococcus. It is found only in oxygenic photosynthetic organisms. TRX is a small enzyme that participate in redox reactions, via the reversible oxidation of an...; Region: TxlA; cd02950 59919000857 catalytic residues [active] 59919000858 1 probable transmembrane helix predicted by TMHMM2.0 59919000859 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 59919000860 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 59919000861 trimer interface [polypeptide binding]; other site 59919000862 active site 59919000863 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; cl17276 59919000864 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 59919000865 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 59919000866 ligand binding site [chemical binding]; other site 59919000867 flexible hinge region; other site 59919000868 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 59919000869 putative switch regulator; other site 59919000870 non-specific DNA interactions [nucleotide binding]; other site 59919000871 DNA binding site [nucleotide binding] 59919000872 sequence specific DNA binding site [nucleotide binding]; other site 59919000873 putative cAMP binding site [chemical binding]; other site 59919000874 Protein of unknown function (DUF3084); Region: DUF3084; pfam11283 59919000875 2 probable transmembrane helices predicted by TMHMM2.0 59919000876 Protein of unknown function (DUF3146); Region: DUF3146; pfam11344 59919000877 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 59919000878 putative active site [active] 59919000879 catalytic residue [active] 59919000880 photosystem II reaction center protein H; Provisional; Region: psbH; PRK02624 59919000881 1 probable transmembrane helix predicted by TMHMM2.0 59919000882 photosystem II reaction center protein N; Provisional; Region: psbN; PRK13183 59919000883 1 probable transmembrane helix predicted by TMHMM2.0 59919000884 photosystem II reaction center I protein I; Provisional; Region: psbI; PRK02655 59919000885 1 probable transmembrane helix predicted by TMHMM2.0 59919000886 Protein of unknown function (DUF3769); Region: DUF3769; pfam12600 59919000887 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 59919000888 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 59919000889 substrate binding site [chemical binding]; other site 59919000890 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 59919000891 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 59919000892 substrate binding site [chemical binding]; other site 59919000893 ligand binding site [chemical binding]; other site 59919000894 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 59919000895 competence damage-inducible protein A; Provisional; Region: PRK00549 59919000896 putative MPT binding site; other site 59919000897 Competence-damaged protein; Region: CinA; pfam02464 59919000898 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 59919000899 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 59919000900 dimer interface [polypeptide binding]; other site 59919000901 active site 59919000902 glycine-pyridoxal phosphate binding site [chemical binding]; other site 59919000903 folate binding site [chemical binding]; other site 59919000904 2 probable transmembrane helices predicted by TMHMM2.0 59919000905 Protein of unknown function (DUF3181); Region: DUF3181; pfam11378 59919000906 integral membrane protein MviN; Region: mviN; TIGR01695 59919000907 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 59919000908 14 probable transmembrane helices predicted by TMHMM2.0 59919000909 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 59919000910 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 59919000911 12 probable transmembrane helices predicted by TMHMM2.0 59919000912 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Provisional; Region: PRK13371 59919000913 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 59919000914 DoxX; Region: DoxX; pfam07681 59919000915 4 probable transmembrane helices predicted by TMHMM2.0 59919000916 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 59919000917 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 59919000918 purine monophosphate binding site [chemical binding]; other site 59919000919 dimer interface [polypeptide binding]; other site 59919000920 putative catalytic residues [active] 59919000921 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 59919000922 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 59919000923 Predicted esterase [General function prediction only]; Region: COG0400 59919000924 putative hydrolase; Provisional; Region: PRK11460 59919000925 Protein of unknown function (DUF3155); Region: DUF3155; pfam11352 59919000926 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 59919000927 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 59919000928 phosphorylation site [posttranslational modification] 59919000929 dimer interface [polypeptide binding]; other site 59919000930 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 59919000931 ATP binding site [chemical binding]; other site 59919000932 Mg2+ binding site [ion binding]; other site 59919000933 G-X-G motif; other site 59919000934 cobalamin synthase; Reviewed; Region: cobS; PRK00235 59919000935 7 probable transmembrane helices predicted by TMHMM2.0 59919000936 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 59919000937 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 59919000938 Photosystem II 4 kDa reaction centre component; Region: PsbK; cl03641 59919000939 1 probable transmembrane helix predicted by TMHMM2.0 59919000940 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 59919000941 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 59919000942 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 59919000943 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 59919000944 Domain of unknown function DUF21; Region: DUF21; pfam01595 59919000945 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 59919000946 Transporter associated domain; Region: CorC_HlyC; smart01091 59919000947 3 probable transmembrane helices predicted by TMHMM2.0 59919000948 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 59919000949 active site 59919000950 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 59919000951 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 59919000952 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 59919000953 CRISPR-associated protein Cas4 (RecB family exonuclease) [Defense mechanisms]; Region: COG1468 59919000954 RecB family nuclease, putative, TM0106 family; Region: TIGR03491 59919000955 RNase_H superfamily; Region: RNase_H_2; pfam13482 59919000956 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 59919000957 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 59919000958 active site 59919000959 substrate binding site [chemical binding]; other site 59919000960 metal binding site [ion binding]; metal-binding site 59919000961 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 59919000962 active site 59919000963 dimerization interface [polypeptide binding]; other site 59919000964 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 59919000965 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 59919000966 imidazoleglycerol-phosphate dehydratase; Region: PLN02800 59919000967 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 59919000968 putative active site pocket [active] 59919000969 4-fold oligomerization interface [polypeptide binding]; other site 59919000970 metal binding residues [ion binding]; metal-binding site 59919000971 3-fold/trimer interface [polypeptide binding]; other site 59919000972 enoyl-(acyl carrier protein) reductase; Validated; Region: PRK07370 59919000973 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 59919000974 NAD binding site [chemical binding]; other site 59919000975 homotetramer interface [polypeptide binding]; other site 59919000976 homodimer interface [polypeptide binding]; other site 59919000977 substrate binding site [chemical binding]; other site 59919000978 active site 59919000979 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 59919000980 putative catalytic residue [active] 59919000981 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 59919000982 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 59919000983 inhibitor-cofactor binding pocket; inhibition site 59919000984 pyridoxal 5'-phosphate binding site [chemical binding]; other site 59919000985 catalytic residue [active] 59919000986 deoxyribodipyrimidine photo-lyase, 8-HDF type; Region: photolyase_8HDF; TIGR03556 59919000987 DNA photolyase; Region: DNA_photolyase; pfam00875 59919000988 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 59919000989 dimer interface [polypeptide binding]; other site 59919000990 ADP-ribose binding site [chemical binding]; other site 59919000991 active site 59919000992 nudix motif; other site 59919000993 metal binding site [ion binding]; metal-binding site 59919000994 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 59919000995 catalytic center binding site [active] 59919000996 ATP binding site [chemical binding]; other site 59919000997 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 59919000998 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 59919000999 metal ion-dependent adhesion site (MIDAS); other site 59919001000 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 59919001001 mce related protein; Region: MCE; pfam02470 59919001002 1 probable transmembrane helix predicted by TMHMM2.0 59919001003 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 59919001004 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 59919001005 Walker A/P-loop; other site 59919001006 ATP binding site [chemical binding]; other site 59919001007 Q-loop/lid; other site 59919001008 ABC transporter signature motif; other site 59919001009 Walker B; other site 59919001010 D-loop; other site 59919001011 H-loop/switch region; other site 59919001012 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 59919001013 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 59919001014 phosphate binding site [ion binding]; other site 59919001015 putative substrate binding pocket [chemical binding]; other site 59919001016 dimer interface [polypeptide binding]; other site 59919001017 2 probable transmembrane helices predicted by TMHMM2.0 59919001018 NADH dehydrogenase subunit J; Provisional; Region: PRK12494 59919001019 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 59919001020 NADH dehydrogenase subunit K; Region: ndhK; CHL00023 59919001021 NADH dehydrogenase subunit 3; Region: ndhC; CHL00022 59919001022 3 probable transmembrane helices predicted by TMHMM2.0 59919001023 Rubredoxin [Energy production and conversion]; Region: COG1773 59919001024 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 59919001025 iron binding site [ion binding]; other site 59919001026 1 probable transmembrane helix predicted by TMHMM2.0 59919001027 Ycf48-like protein; Provisional; Region: PRK13684 59919001028 cytochrome b559 subunit alpha; Provisional; Region: psbE; PRK02557 59919001029 Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits; Region: Cytochrom_B559; pfam00283 59919001030 Lumenal portion of Cytochrome b559, alpha (gene psbE) subunit; Region: Cytochrom_B559a; pfam00284 59919001031 1 probable transmembrane helix predicted by TMHMM2.0 59919001032 cytochrome b559 subunit beta; Provisional; Region: psbF; PRK02561 59919001033 1 probable transmembrane helix predicted by TMHMM2.0 59919001034 PsbL protein; Region: PsbL; cl03581 59919001035 1 probable transmembrane helix predicted by TMHMM2.0 59919001036 photosystem II reaction center protein J; Provisional; Region: PRK02565 59919001037 1 probable transmembrane helix predicted by TMHMM2.0 59919001038 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 59919001039 pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169 59919001040 selenophosphate synthetase; Provisional; Region: PRK14105 59919001041 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 59919001042 dimerization interface [polypeptide binding]; other site 59919001043 putative ATP binding site [chemical binding]; other site 59919001044 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 59919001045 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 59919001046 active site 59919001047 NTP binding site [chemical binding]; other site 59919001048 metal binding triad [ion binding]; metal-binding site 59919001049 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 59919001050 Part of AAA domain; Region: AAA_19; pfam13245 59919001051 Family description; Region: UvrD_C_2; pfam13538 59919001052 Phycobilisome protein; Region: Phycobilisome; cl08227 59919001053 CpeS-like protein; Region: CpeS; pfam09367 59919001054 5 probable transmembrane helices predicted by TMHMM2.0 59919001055 1 probable transmembrane helix predicted by TMHMM2.0 59919001056 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 59919001057 nucleotide binding site [chemical binding]; other site 59919001058 S-adenosylmethionine synthetase; Validated; Region: PRK05250 59919001059 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 59919001060 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 59919001061 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 59919001062 30S ribosomal protein S1; Reviewed; Region: PRK07400 59919001063 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 59919001064 RNA binding site [nucleotide binding]; other site 59919001065 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 59919001066 RNA binding site [nucleotide binding]; other site 59919001067 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 59919001068 RNA binding site [nucleotide binding]; other site 59919001069 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 59919001070 Transcription factor S-II (TFIIS); Region: TFIIS_C; cl02609 59919001071 ATP cone domain; Region: ATP-cone; pfam03477 59919001072 photosystem II reaction center protein T; Reviewed; Region: psbT; PRK11875 59919001073 1 probable transmembrane helix predicted by TMHMM2.0 59919001074 photosystem II chlorophyll-binding protein CP47; Region: PS_II_CP47; TIGR03039 59919001075 6 probable transmembrane helices predicted by TMHMM2.0 59919001076 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 59919001077 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 59919001078 catalytic loop [active] 59919001079 iron binding site [ion binding]; other site 59919001080 photosystem II reaction center protein M; Provisional; Region: psbM; PRK14094 59919001081 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 59919001082 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 59919001083 S-adenosylmethionine binding site [chemical binding]; other site 59919001084 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 59919001085 cell division topological specificity factor MinE; Provisional; Region: PRK13988 59919001086 septum site-determining protein MinD; Region: minD_bact; TIGR01968 59919001087 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 59919001088 P-loop; other site 59919001089 ADP binding residues [chemical binding]; other site 59919001090 Switch I; other site 59919001091 Switch II; other site 59919001092 Septum formation inhibitor [Cell division and chromosome partitioning]; Region: MinC; COG0850 59919001093 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 59919001094 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 59919001095 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 59919001096 Zn2+ binding site [ion binding]; other site 59919001097 Mg2+ binding site [ion binding]; other site 59919001098 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 59919001099 C-terminal peptidase (prc); Region: prc; TIGR00225 59919001100 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 59919001101 protein binding site [polypeptide binding]; other site 59919001102 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 59919001103 Catalytic dyad [active] 59919001104 1 probable transmembrane helix predicted by TMHMM2.0 59919001105 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 59919001106 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 59919001107 Qi binding site; other site 59919001108 intrachain domain interface; other site 59919001109 interchain domain interface [polypeptide binding]; other site 59919001110 heme bH binding site [chemical binding]; other site 59919001111 heme bL binding site [chemical binding]; other site 59919001112 Qo binding site; other site 59919001113 5 probable transmembrane helices predicted by TMHMM2.0 59919001114 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 59919001115 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 59919001116 interchain domain interface [polypeptide binding]; other site 59919001117 intrachain domain interface; other site 59919001118 Qi binding site; other site 59919001119 Qo binding site; other site 59919001120 3 probable transmembrane helices predicted by TMHMM2.0 59919001121 Alkaline and neutral invertase; Region: Glyco_hydro_100; pfam12899 59919001122 formamidopyrimidine-DNA glycosylase; Provisional; Region: PRK13945 59919001123 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 59919001124 DNA binding site [nucleotide binding] 59919001125 catalytic residue [active] 59919001126 H2TH interface [polypeptide binding]; other site 59919001127 putative catalytic residues [active] 59919001128 turnover-facilitating residue; other site 59919001129 intercalation triad [nucleotide binding]; other site 59919001130 8OG recognition residue [nucleotide binding]; other site 59919001131 putative reading head residues; other site 59919001132 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 59919001133 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 59919001134 photosystem I reaction center subunit IV; Provisional; Region: PRK02749 59919001135 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 59919001136 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 59919001137 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 59919001138 NAD(P) binding site [chemical binding]; other site 59919001139 catalytic residues [active] 59919001140 5 probable transmembrane helices predicted by TMHMM2.0 59919001141 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 59919001142 Coenzyme A binding pocket [chemical binding]; other site 59919001143 Protein of unknown function (DUF3104); Region: DUF3104; pfam11302 59919001144 4 probable transmembrane helices predicted by TMHMM2.0 59919001145 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 59919001146 dinuclear metal binding motif [ion binding]; other site 59919001147 1 probable transmembrane helix predicted by TMHMM2.0 59919001148 conserved hypothetical protein, TIGR03894 family; Region: chp_P_marinus_1 59919001149 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 59919001150 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 59919001151 1 probable transmembrane helix predicted by TMHMM2.0 59919001152 Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862 59919001153 2 probable transmembrane helices predicted by TMHMM2.0 59919001154 twin arginine translocase protein A; Provisional; Region: tatA; PRK14857 59919001155 1 probable transmembrane helix predicted by TMHMM2.0 59919001156 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 59919001157 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 59919001158 catalytic triad [active] 59919001159 Protein of unknown function (DUF4090); Region: DUF4090; pfam13319 59919001160 3 probable transmembrane helices predicted by TMHMM2.0 59919001161 hypothetical protein; Provisional; Region: PRK09256 59919001162 Protein of unknown function (DUF1651); Region: DUF1651; pfam07864 59919001163 CAAX protease self-immunity; Region: Abi; pfam02517 59919001164 8 probable transmembrane helices predicted by TMHMM2.0 59919001165 GDP-fucose protein O-fucosyltransferase and related proteins; Region: O-FucT_like; cl16914 59919001166 GDP-Fucose binding site [chemical binding]; other site 59919001167 Protein of unknown function (DUF1330); Region: DUF1330; pfam07045 59919001168 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 59919001169 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 59919001170 TAP-like protein; Region: Abhydrolase_4; pfam08386 59919001171 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 59919001172 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 59919001173 substrate binding site [chemical binding]; other site 59919001174 dimer interface [polypeptide binding]; other site 59919001175 ATP binding site [chemical binding]; other site 59919001176 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 59919001177 1 probable transmembrane helix predicted by TMHMM2.0 59919001178 MarR family; Region: MarR_2; pfam12802 59919001179 Protein of unknown function (DUF3303); Region: DUF3303; pfam11746 59919001180 DsrE/DsrF-like family; Region: DrsE; pfam02635 59919001181 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 59919001182 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 59919001183 Protein of unknown function (DUF3303); Region: DUF3303; pfam11746 59919001184 NMT1-like family; Region: NMT1_2; pfam13379 59919001185 NMT1/THI5 like; Region: NMT1; pfam09084 59919001186 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 59919001187 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 59919001188 dimer interface [polypeptide binding]; other site 59919001189 conserved gate region; other site 59919001190 putative PBP binding loops; other site 59919001191 ABC-ATPase subunit interface; other site 59919001192 5 probable transmembrane helices predicted by TMHMM2.0 59919001193 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 59919001194 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 59919001195 Walker A/P-loop; other site 59919001196 ATP binding site [chemical binding]; other site 59919001197 Q-loop/lid; other site 59919001198 ABC transporter signature motif; other site 59919001199 Walker B; other site 59919001200 D-loop; other site 59919001201 H-loop/switch region; other site 59919001202 cyanate hydratase; Validated; Region: PRK02866 59919001203 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 59919001204 oligomer interface [polypeptide binding]; other site 59919001205 active site 59919001206 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 59919001207 1 probable transmembrane helix predicted by TMHMM2.0 59919001208 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 59919001209 Protein of unknown function (DUF3303); Region: DUF3303; pfam11746 59919001210 Protein of unknown function (DUF3303); Region: DUF3303; pfam11746 59919001211 Protein of unknown function (DUF1348); Region: DUF1348; pfam07080 59919001212 SnoaL-like domain; Region: SnoaL_2; pfam12680 59919001213 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 59919001214 1 probable transmembrane helix predicted by TMHMM2.0 59919001215 This entry represents the putative helicase A859L; Region: T5orf172; smart00974 59919001217 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 59919001218 Dehydroquinase class II; Region: DHquinase_II; pfam01220 59919001219 active site 59919001220 trimer interface [polypeptide binding]; other site 59919001221 dimer interface [polypeptide binding]; other site 59919001222 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 59919001223 active site 59919001224 dinuclear metal binding site [ion binding]; other site 59919001225 dimerization interface [polypeptide binding]; other site 59919001226 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 59919001227 active site 59919001228 SAM binding site [chemical binding]; other site 59919001229 homodimer interface [polypeptide binding]; other site 59919001230 Domain of unknown function (DUF1823); Region: DUF1823; pfam08853 59919001231 GTP-binding protein Der; Reviewed; Region: PRK00093 59919001232 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 59919001233 G1 box; other site 59919001234 GTP/Mg2+ binding site [chemical binding]; other site 59919001235 Switch I region; other site 59919001236 G2 box; other site 59919001237 Switch II region; other site 59919001238 G3 box; other site 59919001239 G4 box; other site 59919001240 G5 box; other site 59919001241 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 59919001242 G1 box; other site 59919001243 GTP/Mg2+ binding site [chemical binding]; other site 59919001244 Switch I region; other site 59919001245 G2 box; other site 59919001246 G3 box; other site 59919001247 Switch II region; other site 59919001248 G4 box; other site 59919001249 G5 box; other site 59919001250 Cobalt transport protein; Region: CbiQ; cl00463 59919001251 5 probable transmembrane helices predicted by TMHMM2.0 59919001252 Protein of unknown function (DUF3539); Region: DUF3539; pfam12058 59919001253 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 59919001254 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 59919001255 catalytic residue [active] 59919001256 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 59919001257 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 59919001258 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 59919001259 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 59919001260 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 59919001261 Recombination protein O N terminal; Region: RecO_N; pfam11967 59919001262 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 59919001263 Recombination protein O C terminal; Region: RecO_C; pfam02565 59919001264 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 59919001265 intersubunit interface [polypeptide binding]; other site 59919001266 active site 59919001267 catalytic residue [active] 59919001268 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 59919001269 30S subunit binding site; other site 59919001270 lipoate-protein ligase B; Provisional; Region: PRK14344 59919001271 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 59919001272 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 59919001273 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 59919001274 acyl-activating enzyme (AAE) consensus motif; other site 59919001275 acyl-activating enzyme (AAE) consensus motif; other site 59919001276 putative AMP binding site [chemical binding]; other site 59919001277 putative active site [active] 59919001278 putative CoA binding site [chemical binding]; other site 59919001279 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 59919001280 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 59919001281 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 59919001282 E3 interaction surface; other site 59919001283 lipoyl attachment site [posttranslational modification]; other site 59919001284 e3 binding domain; Region: E3_binding; pfam02817 59919001285 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 59919001286 Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547 59919001287 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 59919001288 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 59919001289 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 59919001290 dimer interface [polypeptide binding]; other site 59919001291 pyridoxal 5'-phosphate binding site [chemical binding]; other site 59919001292 catalytic residue [active] 59919001293 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 59919001294 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 59919001295 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 59919001296 catalytic residue [active] 59919001297 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 59919001298 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 59919001299 homodimer interface [polypeptide binding]; other site 59919001300 substrate-cofactor binding pocket; other site 59919001301 pyridoxal 5'-phosphate binding site [chemical binding]; other site 59919001302 catalytic residue [active] 59919001303 ribosomal protein S4; Reviewed; Region: rps4; CHL00113 59919001304 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 59919001305 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 59919001306 RNA binding surface [nucleotide binding]; other site 59919001307 hypothetical protein; Provisional; Region: PRK14390 59919001308 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 59919001309 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 59919001310 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 59919001311 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 59919001312 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 59919001313 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 59919001314 NAD(P) binding site [chemical binding]; other site 59919001315 active site 59919001316 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 59919001317 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 59919001318 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 59919001319 catalytic residue [active] 59919001320 Methyltransferase domain; Region: Methyltransf_31; pfam13847 59919001321 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 59919001322 S-adenosylmethionine binding site [chemical binding]; other site 59919001323 2 probable transmembrane helices predicted by TMHMM2.0 59919001324 NifU-like domain; Region: NifU; pfam01106 59919001325 malate:quinone oxidoreductase; Validated; Region: PRK05257 59919001326 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 59919001327 GTP-binding protein LepA; Provisional; Region: PRK05433 59919001328 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 59919001329 G1 box; other site 59919001330 putative GEF interaction site [polypeptide binding]; other site 59919001331 GTP/Mg2+ binding site [chemical binding]; other site 59919001332 Switch I region; other site 59919001333 G2 box; other site 59919001334 G3 box; other site 59919001335 Switch II region; other site 59919001336 G4 box; other site 59919001337 G5 box; other site 59919001338 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 59919001339 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 59919001340 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 59919001341 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 59919001342 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 59919001343 dimer interface [polypeptide binding]; other site 59919001344 conserved gate region; other site 59919001345 putative PBP binding loops; other site 59919001346 ABC-ATPase subunit interface; other site 59919001347 6 probable transmembrane helices predicted by TMHMM2.0 59919001348 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 59919001349 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 59919001350 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 59919001351 Protein of unknown function, DUF393; Region: DUF393; pfam04134 59919001352 TIGR03643 family protein; Region: TIGR03643 59919001353 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 59919001354 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 59919001355 16S rRNA methyltransferase B; Provisional; Region: PRK14901 59919001356 NusB family; Region: NusB; pfam01029 59919001357 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 59919001358 S-adenosylmethionine binding site [chemical binding]; other site 59919001359 Transglycosylase; Region: Transgly; pfam00912 59919001360 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 59919001361 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 59919001362 1 probable transmembrane helix predicted by TMHMM2.0 59919001363 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 59919001364 UbiA prenyltransferase family; Region: UbiA; pfam01040 59919001365 8 probable transmembrane helices predicted by TMHMM2.0 59919001366 Protein of unknown function (DUF2862); Region: DUF2862; pfam11061 59919001367 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 59919001368 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 59919001369 substrate binding site [chemical binding]; other site 59919001370 glutamase interaction surface [polypeptide binding]; other site 59919001371 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 59919001372 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 59919001373 S-adenosylmethionine binding site [chemical binding]; other site 59919001374 Protein of unknown function (DUF721); Region: DUF721; pfam05258 59919001375 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 59919001376 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 59919001377 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 59919001378 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 59919001379 Walker A/P-loop; other site 59919001380 ATP binding site [chemical binding]; other site 59919001381 Q-loop/lid; other site 59919001382 ABC transporter signature motif; other site 59919001383 Walker B; other site 59919001384 D-loop; other site 59919001385 H-loop/switch region; other site 59919001386 NAD(P)H-quinone oxidoreductase subunit 2; Provisional; Region: PRK02504 59919001387 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 59919001388 13 probable transmembrane helices predicted by TMHMM2.0 59919001389 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 59919001390 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 59919001391 active site 59919001392 interdomain interaction site; other site 59919001393 putative metal-binding site [ion binding]; other site 59919001394 nucleotide binding site [chemical binding]; other site 59919001395 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 59919001396 domain I; other site 59919001397 phosphate binding site [ion binding]; other site 59919001398 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 59919001399 domain II; other site 59919001400 domain III; other site 59919001401 nucleotide binding site [chemical binding]; other site 59919001402 DNA binding groove [nucleotide binding] 59919001403 catalytic site [active] 59919001404 domain IV; other site 59919001405 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 59919001406 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 59919001407 4 probable transmembrane helices predicted by TMHMM2.0 59919001408 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 59919001409 putative dimer interface [polypeptide binding]; other site 59919001410 active site pocket [active] 59919001411 putative cataytic base [active] 59919001412 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 59919001413 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 59919001414 active site 59919001415 catalytic tetrad [active] 59919001416 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 59919001417 Lumazine binding domain; Region: Lum_binding; pfam00677 59919001418 Lumazine binding domain; Region: Lum_binding; pfam00677 59919001419 AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250 59919001420 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 59919001421 Subunit I/III interface [polypeptide binding]; other site 59919001422 5 probable transmembrane helices predicted by TMHMM2.0 59919001423 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 59919001424 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 59919001425 12 probable transmembrane helices predicted by TMHMM2.0 59919001426 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 59919001427 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 59919001428 3 probable transmembrane helices predicted by TMHMM2.0 59919001429 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 59919001430 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 59919001431 8 probable transmembrane helices predicted by TMHMM2.0 59919001432 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 59919001433 UbiA prenyltransferase family; Region: UbiA; pfam01040 59919001434 7 probable transmembrane helices predicted by TMHMM2.0 59919001435 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 59919001436 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 59919001437 Walker A/P-loop; other site 59919001438 ATP binding site [chemical binding]; other site 59919001439 Q-loop/lid; other site 59919001440 ABC transporter signature motif; other site 59919001441 Walker B; other site 59919001442 D-loop; other site 59919001443 H-loop/switch region; other site 59919001444 ABC-2 type transporter; Region: ABC2_membrane; cl17235 59919001445 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 59919001446 6 probable transmembrane helices predicted by TMHMM2.0 59919001447 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 59919001448 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 59919001449 ring oligomerisation interface [polypeptide binding]; other site 59919001450 ATP/Mg binding site [chemical binding]; other site 59919001451 stacking interactions; other site 59919001452 hinge regions; other site 59919001453 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 59919001454 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 59919001455 NAD(P) binding site [chemical binding]; other site 59919001456 homotetramer interface [polypeptide binding]; other site 59919001457 homodimer interface [polypeptide binding]; other site 59919001458 active site 59919001459 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 59919001460 substrate binding site; other site 59919001461 dimer interface; other site 59919001462 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 59919001463 dimer interface [polypeptide binding]; other site 59919001464 catalytic triad [active] 59919001465 prenyltransferase; Reviewed; Region: ubiA; PRK12873 59919001466 UbiA prenyltransferase family; Region: UbiA; pfam01040 59919001467 7 probable transmembrane helices predicted by TMHMM2.0 59919001468 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 59919001469 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 59919001470 Helix-turn-helix domain; Region: HTH_25; pfam13413 59919001471 non-specific DNA binding site [nucleotide binding]; other site 59919001472 salt bridge; other site 59919001473 sequence-specific DNA binding site [nucleotide binding]; other site 59919001474 1 probable transmembrane helix predicted by TMHMM2.0 59919001475 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 59919001476 active site 59919001477 SAM binding site [chemical binding]; other site 59919001478 homodimer interface [polypeptide binding]; other site 59919001479 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 59919001480 7 probable transmembrane helices predicted by TMHMM2.0 59919001481 apocytochrome f; Reviewed; Region: PRK02693 59919001482 cytochrome f; Region: petA; CHL00037 59919001483 2 probable transmembrane helices predicted by TMHMM2.0 59919001484 cytochrome b6-f complex iron-sulfur subunit; Provisional; Region: PRK13474 59919001485 Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802 59919001486 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 59919001487 iron-sulfur cluster [ion binding]; other site 59919001488 [2Fe-2S] cluster binding site [ion binding]; other site 59919001489 1 probable transmembrane helix predicted by TMHMM2.0 59919001490 Protein of unknown function (DUF3067); Region: DUF3067; pfam11267 59919001491 Sec-independent translocase component C; Provisional; Region: tatC; CHL00182 59919001492 6 probable transmembrane helices predicted by TMHMM2.0 59919001493 1 probable transmembrane helix predicted by TMHMM2.0 59919001494 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 59919001495 Domain of unknown function (DUF814); Region: DUF814; pfam05670 59919001496 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 59919001497 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 59919001498 catalytic site [active] 59919001499 G-X2-G-X-G-K; other site 59919001500 photosystem I reaction center subunit IX; Provisional; Region: PRK02733 59919001501 1 probable transmembrane helix predicted by TMHMM2.0 59919001502 Photosystem I reaction centre subunit III; Region: PSI_PsaF; cl03627 59919001503 2 probable transmembrane helices predicted by TMHMM2.0 59919001504 tRNA threonylcarbamoyl adenosine modification protein YgjD; Region: T6A_YgjD; TIGR03723 59919001505 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 59919001506 1 probable transmembrane helix predicted by TMHMM2.0 59919001507 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 59919001508 10 probable transmembrane helices predicted by TMHMM2.0 59919001509 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 59919001510 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 59919001511 active site 59919001512 HIGH motif; other site 59919001513 nucleotide binding site [chemical binding]; other site 59919001514 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 59919001515 active site 59919001516 KMSKS motif; other site 59919001517 Src Homology 3 domain superfamily; Region: SH3; cl17036 59919001518 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 59919001519 2 probable transmembrane helices predicted by TMHMM2.0 59919001520 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 59919001521 active site 59919001522 short chain dehydrogenase; Provisional; Region: PRK12367 59919001523 NAD(P) binding site [chemical binding]; other site 59919001524 BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857 59919001525 DRTGG domain; Region: DRTGG; pfam07085 59919001526 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 59919001527 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 59919001528 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 59919001529 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 59919001530 SPFH domain / Band 7 family; Region: Band_7; pfam01145 59919001531 1 probable transmembrane helix predicted by TMHMM2.0 59919001532 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 59919001533 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 59919001534 inhibitor-cofactor binding pocket; inhibition site 59919001535 pyridoxal 5'-phosphate binding site [chemical binding]; other site 59919001536 catalytic residue [active] 59919001537 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 59919001538 putative catalytic site [active] 59919001539 putative phosphate binding site [ion binding]; other site 59919001540 active site 59919001541 metal binding site A [ion binding]; metal-binding site 59919001542 DNA binding site [nucleotide binding] 59919001543 putative AP binding site [nucleotide binding]; other site 59919001544 putative metal binding site B [ion binding]; other site 59919001545 hypothetical protein; Provisional; Region: PRK04194 59919001546 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 59919001547 7 probable transmembrane helices predicted by TMHMM2.0 59919001548 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 59919001549 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 59919001550 dimer interface [polypeptide binding]; other site 59919001551 conserved gate region; other site 59919001552 putative PBP binding loops; other site 59919001553 ABC-ATPase subunit interface; other site 59919001554 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 59919001555 dimer interface [polypeptide binding]; other site 59919001556 conserved gate region; other site 59919001557 putative PBP binding loops; other site 59919001558 ABC-ATPase subunit interface; other site 59919001559 11 probable transmembrane helices predicted by TMHMM2.0 59919001560 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 59919001561 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 59919001562 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 59919001563 pterin-4-alpha-carbinolamine dehydratase; Validated; Region: phhB; PRK00823 59919001564 aromatic arch; other site 59919001565 DCoH dimer interaction site [polypeptide binding]; other site 59919001566 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 59919001567 DCoH tetramer interaction site [polypeptide binding]; other site 59919001568 substrate binding site [chemical binding]; other site 59919001569 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 59919001570 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 59919001571 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 59919001572 active site 59919001573 Zn binding site [ion binding]; other site 59919001574 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 59919001575 dimer interface [polypeptide binding]; other site 59919001576 substrate binding site [chemical binding]; other site 59919001577 metal binding sites [ion binding]; metal-binding site 59919001578 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 59919001579 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 59919001580 domain interfaces; other site 59919001581 active site 59919001582 RNA polymerase sigma factor RpoD; Validated; Region: PRK07406 59919001583 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 59919001584 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 59919001585 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 59919001586 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 59919001587 DNA binding residues [nucleotide binding] 59919001588 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 59919001589 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 59919001590 ATP binding site [chemical binding]; other site 59919001591 putative Mg++ binding site [ion binding]; other site 59919001592 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 59919001593 ATP-binding site [chemical binding]; other site 59919001594 Protein of unknown function (DUF3153); Region: DUF3153; pfam11353 59919001595 2 probable transmembrane helices predicted by TMHMM2.0 59919001596 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 59919001597 feedback inhibition sensing region; other site 59919001598 homohexameric interface [polypeptide binding]; other site 59919001599 nucleotide binding site [chemical binding]; other site 59919001600 N-acetyl-L-glutamate binding site [chemical binding]; other site 59919001601 Protein of unknown function (DUF2854); Region: DUF2854; pfam11016 59919001602 2 probable transmembrane helices predicted by TMHMM2.0 59919001603 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 59919001604 ssDNA binding site [nucleotide binding]; other site 59919001605 dimer interface [polypeptide binding]; other site 59919001606 tetramer (dimer of dimers) interface [polypeptide binding]; other site 59919001607 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 59919001608 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 59919001609 CutA1 divalent ion tolerance protein; Region: CutA1; cl00584 59919001610 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 59919001611 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 59919001612 substrate binding site [chemical binding]; other site 59919001613 ATP binding site [chemical binding]; other site 59919001614 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 59919001615 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 59919001616 GDP-binding site [chemical binding]; other site 59919001617 ACT binding site; other site 59919001618 IMP binding site; other site 59919001619 photosystem II protein Psb27; Region: PS_II_psb27; TIGR03044 59919001620 1 probable transmembrane helix predicted by TMHMM2.0 59919001621 prolyl-tRNA synthetase; Provisional; Region: PRK09194 59919001622 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 59919001623 motif 1; other site 59919001624 dimer interface [polypeptide binding]; other site 59919001625 active site 59919001626 motif 2; other site 59919001627 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 59919001628 putative deacylase active site [active] 59919001629 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 59919001630 active site 59919001631 motif 3; other site 59919001632 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 59919001633 anticodon binding site; other site 59919001634 1 probable transmembrane helix predicted by TMHMM2.0 59919001635 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 59919001636 dimer interface [polypeptide binding]; other site 59919001637 substrate binding site [chemical binding]; other site 59919001638 metal binding sites [ion binding]; metal-binding site 59919001639 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 59919001640 ArsC family; Region: ArsC; pfam03960 59919001641 putative ArsC-like catalytic residues; other site 59919001642 putative TRX-like catalytic residues [active] 59919001643 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 59919001644 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 59919001645 Catalytic site [active] 59919001646 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 59919001647 dihydroorotase; Provisional; Region: PRK07369 59919001648 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 59919001649 active site 59919001650 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 59919001651 catalytic core [active] 59919001652 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 59919001653 catalytic core [active] 59919001654 CAAX protease self-immunity; Region: Abi; pfam02517 59919001655 8 probable transmembrane helices predicted by TMHMM2.0 59919001656 1 probable transmembrane helix predicted by TMHMM2.0 59919001657 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 59919001658 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 59919001659 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 59919001660 1 probable transmembrane helix predicted by TMHMM2.0 59919001661 transaldolase-like protein; Provisional; Region: PTZ00411 59919001662 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 59919001663 active site 59919001664 dimer interface [polypeptide binding]; other site 59919001665 catalytic residue [active] 59919001666 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 59919001667 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 59919001668 ribosome recycling factor; Reviewed; Region: frr; PRK00083 59919001669 hinge region; other site 59919001670 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 59919001671 putative nucleotide binding site [chemical binding]; other site 59919001672 uridine monophosphate binding site [chemical binding]; other site 59919001673 homohexameric interface [polypeptide binding]; other site 59919001674 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 59919001675 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 59919001676 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 59919001677 homodimer interface [polypeptide binding]; other site 59919001678 Walker A motif; other site 59919001679 ATP binding site [chemical binding]; other site 59919001680 hydroxycobalamin binding site [chemical binding]; other site 59919001681 Walker B motif; other site 59919001682 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 59919001683 active site 59919001684 catalytic residues [active] 59919001685 DNA binding site [nucleotide binding] 59919001686 Int/Topo IB signature motif; other site 59919001687 ferrochelatase; Reviewed; Region: hemH; PRK00035 59919001688 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 59919001689 C-terminal domain interface [polypeptide binding]; other site 59919001690 active site 59919001691 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 59919001692 active site 59919001693 N-terminal domain interface [polypeptide binding]; other site 59919001694 acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK07418 59919001695 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 59919001696 PYR/PP interface [polypeptide binding]; other site 59919001697 dimer interface [polypeptide binding]; other site 59919001698 TPP binding site [chemical binding]; other site 59919001699 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 59919001700 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 59919001701 TPP-binding site [chemical binding]; other site 59919001702 dimer interface [polypeptide binding]; other site 59919001703 1 probable transmembrane helix predicted by TMHMM2.0 59919001704 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 59919001705 Protein of unknown function (DUF1092); Region: DUF1092; pfam06485 59919001706 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 59919001707 RNA binding site [nucleotide binding]; other site 59919001708 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 59919001709 RNA binding site [nucleotide binding]; other site 59919001710 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 59919001711 RNA binding site [nucleotide binding]; other site 59919001712 Creatinine amidohydrolase; Region: Creatininase; pfam02633 59919001713 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 59919001714 dinuclear metal binding motif [ion binding]; other site 59919001715 acyl-ACP reductase; Provisional; Region: PRK14982 59919001716 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 59919001717 NAD(P) binding pocket [chemical binding]; other site 59919001718 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 59919001719 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 59919001720 short chain dehydrogenase; Provisional; Region: PRK07454 59919001721 classical (c) SDRs; Region: SDR_c; cd05233 59919001722 NAD(P) binding site [chemical binding]; other site 59919001723 active site 59919001724 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 59919001725 GTP cyclohydrolase I; Provisional; Region: PLN03044 59919001726 active site 59919001727 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 59919001728 active site 59919001729 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 59919001730 active site 59919001731 putative substrate binding region [chemical binding]; other site 59919001732 5 probable transmembrane helices predicted by TMHMM2.0 59919001733 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 59919001734 photosystem I reaction center subunit XII; Reviewed; Region: psaM; PRK11878 59919001735 1 probable transmembrane helix predicted by TMHMM2.0 59919001736 protochlorophyllide oxidoreductase; Validated; Region: PRK07453 59919001737 light-dependent protochlorophyllide reductase; Region: LPOR; TIGR01289 59919001738 NAD(P) binding site [chemical binding]; other site 59919001739 active site 59919001740 protochlorophyllide reductase iron-sulfur ATP-binding protein; Provisional; Region: chlL; PRK13185 59919001741 This family of proteins contains bchL and chlL. Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. Three genes, bchL, bchN and bchB, are...; Region: Bchl_like; cd02032 59919001742 P-loop; other site 59919001743 light-independent protochlorophyllide reductase subunit B; Provisional; Region: PRK02910 59919001744 Pchlide_reductase_B: B protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_B; cd01981 59919001745 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 59919001746 light-independent protochlorophyllide reductase subunit N; Provisional; Region: PRK02842 59919001747 light-independent protochlorophyllide reductase, N subunit; Region: DPOR_bchN; TIGR01279 59919001748 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 1; Region: BMC_like_1_repeat1; cd07051 59919001749 putative hexamer interface [polypeptide binding]; other site 59919001750 putative hexagonal pore; other site 59919001751 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 2; Region: BMC_like_1_repeat2; cd07052 59919001752 putative hexamer interface [polypeptide binding]; other site 59919001753 putative hexagonal pore; other site 59919001754 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 59919001755 active site 59919001756 dimerization interface [polypeptide binding]; other site 59919001757 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 59919001758 Carboxysome Shell 1 (CsoS1); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CsoS1; cd07058 59919001759 Hexamer interface [polypeptide binding]; other site 59919001760 Hexagonal pore residue; other site 59919001761 Hexagonal pore; other site 59919001762 ribulose bisophosphate carboxylase; Reviewed; Region: rbcL; PRK04208 59919001763 Ribulose bisphosphate carboxylase large chain; Region: RuBisCO_large; cl08232 59919001764 dimer interface [polypeptide binding]; other site 59919001765 catalytic residue [active] 59919001766 metal binding site [ion binding]; metal-binding site 59919001767 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527 59919001768 multimerization interface [polypeptide binding]; other site 59919001769 Carboxysome shell peptide mid-region; Region: CsoS2_M; pfam12288 59919001770 Carboxysome Shell Carbonic Anhydrase; Region: CsoSCA; pfam08936 59919001771 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 59919001772 Hexamer/Pentamer interface [polypeptide binding]; other site 59919001773 central pore; other site 59919001774 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 59919001775 Hexamer/Pentamer interface [polypeptide binding]; other site 59919001776 central pore; other site 59919001777 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cl00942 59919001778 DCoH dimer interaction site [polypeptide binding]; other site 59919001779 aromatic arch; other site 59919001780 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 59919001781 DCoH tetramer interaction site [polypeptide binding]; other site 59919001782 substrate binding site [chemical binding]; other site 59919001783 Protein of unknown function (DUF3136); Region: DUF3136; pfam11334 59919001784 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 59919001785 homotrimer interaction site [polypeptide binding]; other site 59919001786 putative active site [active] 59919001787 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 59919001788 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 59919001789 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 59919001790 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 59919001791 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 59919001792 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 59919001793 Walker A/P-loop; other site 59919001794 ATP binding site [chemical binding]; other site 59919001795 Q-loop/lid; other site 59919001796 ABC transporter signature motif; other site 59919001797 Walker B; other site 59919001798 D-loop; other site 59919001799 H-loop/switch region; other site 59919001800 5 probable transmembrane helices predicted by TMHMM2.0 59919001801 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 59919001802 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 59919001803 Coenzyme A binding pocket [chemical binding]; other site 59919001804 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 59919001805 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 59919001806 Probable Catalytic site; other site 59919001807 Uncharacterized protein conserved in bacteria (DUF2064); Region: DUF2064; cl17492 59919001808 DnaA N-terminal domain; Region: DnaA_N; pfam11638 59919001809 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 59919001810 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 59919001811 Walker A motif; other site 59919001812 ATP binding site [chemical binding]; other site 59919001813 Walker B motif; other site 59919001814 arginine finger; other site 59919001815 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 59919001816 DnaA box-binding interface [nucleotide binding]; other site 59919001817 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 59919001818 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 59919001819 C-terminal domain interface [polypeptide binding]; other site 59919001820 GSH binding site (G-site) [chemical binding]; other site 59919001821 dimer interface [polypeptide binding]; other site 59919001822 glutathione reductase; Validated; Region: PRK06116 59919001823 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 59919001824 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 59919001825 K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367 59919001826 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 59919001827 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 59919001828 11 probable transmembrane helices predicted by TMHMM2.0 59919001829 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 59919001830 active site 59919001831 substrate binding pocket [chemical binding]; other site 59919001832 dimer interface [polypeptide binding]; other site 59919001833 NADH dehydrogenase transmembrane subunit; Region: NdhL; pfam10716 59919001834 2 probable transmembrane helices predicted by TMHMM2.0 59919001835 Protein of unknown function (DUF3007); Region: DUF3007; pfam11460 59919001836 2 probable transmembrane helices predicted by TMHMM2.0 59919001837 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 59919001838 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 59919001839 substrate binding site [chemical binding]; other site 59919001840 active site 59919001841 catalytic residues [active] 59919001842 heterodimer interface [polypeptide binding]; other site 59919001843 AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250 59919001844 YciI-like protein; Reviewed; Region: PRK12864 59919001845 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 59919001846 Uncharacterized conserved protein [Function unknown]; Region: COG3339 59919001847 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 59919001848 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 59919001849 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 59919001850 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 59919001851 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 59919001852 DNA binding residues [nucleotide binding] 59919001853 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 59919001854 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 59919001855 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 59919001856 metal binding site [ion binding]; metal-binding site 59919001857 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 59919001858 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 59919001859 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 59919001860 Walker A motif; other site 59919001861 ATP binding site [chemical binding]; other site 59919001862 Walker B motif; other site 59919001863 arginine finger; other site 59919001864 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 59919001865 Walker A motif; other site 59919001866 ATP binding site [chemical binding]; other site 59919001867 Walker B motif; other site 59919001868 arginine finger; other site 59919001869 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 59919001870 plastocyanin; Provisional; Region: PRK02710 59919001871 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 59919001872 1 probable transmembrane helix predicted by TMHMM2.0 59919001873 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 59919001874 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 59919001875 NAD(P) binding site [chemical binding]; other site 59919001876 active site 59919001877 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 59919001878 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 59919001879 substrate binding site [chemical binding]; other site 59919001880 active site 59919001881 glycogen branching enzyme; Provisional; Region: PRK05402 59919001882 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 59919001883 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 59919001884 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 59919001885 active site 59919001886 catalytic site [active] 59919001887 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 59919001888 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 59919001889 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 59919001890 Domain of unknown function (DUF4332); Region: DUF4332; pfam14229 59919001891 Protein of function (DUF2518); Region: DUF2518; pfam10726 59919001892 2 probable transmembrane helices predicted by TMHMM2.0 59919001893 Family of unknown function (DUF490); Region: DUF490; pfam04357 59919001894 1 probable transmembrane helix predicted by TMHMM2.0 59919001895 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 59919001896 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 59919001897 putative catalytic cysteine [active] 59919001898 Dihydroneopterin aldolase; Region: FolB; smart00905 59919001899 active site 59919001900 Lipase (class 2); Region: Lipase_2; pfam01674 59919001901 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 59919001902 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 59919001903 active site 59919001904 Zn binding site [ion binding]; other site 59919001905 NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK12561 59919001906 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 59919001907 13 probable transmembrane helices predicted by TMHMM2.0 59919001908 homoserine kinase; Provisional; Region: PRK01212 59919001909 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 59919001910 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 59919001911 glucokinase, proteobacterial type; Region: glk; TIGR00749 59919001912 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 59919001913 nucleotide binding site [chemical binding]; other site 59919001914 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 59919001915 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 59919001916 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 59919001917 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 59919001918 active site 59919001919 dimer interface [polypeptide binding]; other site 59919001920 motif 1; other site 59919001921 motif 2; other site 59919001922 motif 3; other site 59919001923 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 59919001924 anticodon binding site; other site 59919001925 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 59919001926 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 59919001927 active site 59919001928 HIGH motif; other site 59919001929 dimer interface [polypeptide binding]; other site 59919001930 KMSKS motif; other site 59919001931 Domain of unknown function (DUF697); Region: DUF697; pfam05128 59919001932 1 probable transmembrane helix predicted by TMHMM2.0 59919001933 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 59919001934 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 59919001935 metal binding site [ion binding]; metal-binding site 59919001936 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 59919001937 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 59919001938 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 59919001939 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 59919001940 ABC-ATPase subunit interface; other site 59919001941 dimer interface [polypeptide binding]; other site 59919001942 putative PBP binding regions; other site 59919001943 7 probable transmembrane helices predicted by TMHMM2.0 59919001944 Domain of unknown function (DUF4336); Region: DUF4336; pfam14234 59919001945 Protein of unknown function (DUF760); Region: DUF760; pfam05542 59919001946 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 59919001947 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 59919001948 Catalytic site [active] 59919001949 1 probable transmembrane helix predicted by TMHMM2.0 59919001950 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase; Region: menD; TIGR00173 59919001951 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 59919001952 dimer interface [polypeptide binding]; other site 59919001953 tetramer interface [polypeptide binding]; other site 59919001954 PYR/PP interface [polypeptide binding]; other site 59919001955 TPP binding site [chemical binding]; other site 59919001956 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 59919001957 TPP-binding site; other site 59919001958 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 59919001959 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 59919001960 substrate binding site [chemical binding]; other site 59919001961 oxyanion hole (OAH) forming residues; other site 59919001962 trimer interface [polypeptide binding]; other site 59919001963 glycogen synthase; Provisional; Region: glgA; PRK00654 59919001964 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 59919001965 ADP-binding pocket [chemical binding]; other site 59919001966 homodimer interface [polypeptide binding]; other site 59919001967 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 59919001968 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 59919001969 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 59919001970 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14360 59919001971 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 59919001972 Substrate binding site; other site 59919001973 Mg++ binding site; other site 59919001974 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 59919001975 active site 59919001976 substrate binding site [chemical binding]; other site 59919001977 CoA binding site [chemical binding]; other site 59919001978 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 59919001979 S-adenosylmethionine binding site [chemical binding]; other site 59919001980 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 59919001981 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 59919001982 hinge; other site 59919001983 active site 59919001984 2-phosphosulfolactate phosphatase; Provisional; Region: PRK00886 59919001985 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 59919001986 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 59919001987 nitrilase; Region: PLN02798 59919001988 putative active site [active] 59919001989 catalytic triad [active] 59919001990 dimer interface [polypeptide binding]; other site 59919001991 AMIN domain; Region: AMIN; pfam11741 59919001992 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 59919001993 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 59919001994 active site 59919001995 metal binding site [ion binding]; metal-binding site 59919001996 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 59919001997 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 59919001998 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 59919001999 substrate binding pocket [chemical binding]; other site 59919002000 chain length determination region; other site 59919002001 substrate-Mg2+ binding site; other site 59919002002 catalytic residues [active] 59919002003 aspartate-rich region 1; other site 59919002004 active site lid residues [active] 59919002005 aspartate-rich region 2; other site 59919002006 acetyl-CoA synthetase; Provisional; Region: PRK00174 59919002007 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 59919002008 active site 59919002009 CoA binding site [chemical binding]; other site 59919002010 acyl-activating enzyme (AAE) consensus motif; other site 59919002011 AMP binding site [chemical binding]; other site 59919002012 acetate binding site [chemical binding]; other site 59919002013 Protein of unknown function (DUF1350); Region: DUF1350; pfam07082 59919002014 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 59919002015 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 59919002016 active site 59919002017 catalytic site [active] 59919002018 substrate binding site [chemical binding]; other site 59919002019 GLTT repeat (6 copies); Region: GLTT; pfam01744 59919002020 GLTT repeat (6 copies); Region: GLTT; pfam01744 59919002021 Protein of unknown function; Region: DUF3721; pfam12518 59919002022 2 probable transmembrane helices predicted by TMHMM2.0 59919002023 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 59919002024 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 59919002025 dimer interface [polypeptide binding]; other site 59919002026 motif 1; other site 59919002027 active site 59919002028 motif 2; other site 59919002029 motif 3; other site 59919002030 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 59919002031 anticodon binding site; other site 59919002032 1 probable transmembrane helix predicted by TMHMM2.0 59919002033 tryptophan-rich conserved hypothetical protein; Region: TIGR02450 59919002034 chlorophyll a/b binding light-harvesting protein; Region: PS_antenn_a_b; TIGR03041 59919002035 6 probable transmembrane helices predicted by TMHMM2.0 59919002036 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 59919002037 12 probable transmembrane helices predicted by TMHMM2.0 59919002038 GST_N family, Omega-like subfamily; composed of uncharacterized proteins with similarity to class Omega GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_Omega_like; cd03060 59919002039 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 59919002040 putative GSH binding site (G-site) [chemical binding]; other site 59919002041 active site cysteine [active] 59919002042 putative C-terminal domain interface [polypeptide binding]; other site 59919002043 putative dimer interface [polypeptide binding]; other site 59919002044 C-terminal, alpha helical domain of an unknown subfamily 5 of Glutathione S-transferases; Region: GST_C_5; cd03196 59919002045 putative N-terminal domain interface [polypeptide binding]; other site 59919002046 putative dimer interface [polypeptide binding]; other site 59919002047 putative substrate binding pocket (H-site) [chemical binding]; other site 59919002048 T5orf172 domain; Region: T5orf172; pfam10544 59919002049 3 probable transmembrane helices predicted by TMHMM2.0 59919002050 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 59919002051 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666 59919002052 NAD(P) binding site [chemical binding]; other site 59919002053 active site 59919002054 lycopene cyclase family protein; Region: carotene-cycl; TIGR01790 59919002055 lycopene cyclase; Region: lycopene_cycl; TIGR01789 59919002056 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 59919002057 NAD(P) binding site [chemical binding]; other site 59919002058 active site 59919002059 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 59919002060 Mechanosensitive ion channel; Region: MS_channel; pfam00924 59919002061 5 probable transmembrane helices predicted by TMHMM2.0 59919002062 Isochorismatase family; Region: Isochorismatase; pfam00857 59919002063 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 59919002064 catalytic triad [active] 59919002065 dimer interface [polypeptide binding]; other site 59919002066 conserved cis-peptide bond; other site 59919002067 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 59919002068 metal binding site 2 [ion binding]; metal-binding site 59919002069 putative DNA binding helix; other site 59919002070 metal binding site 1 [ion binding]; metal-binding site 59919002071 dimer interface [polypeptide binding]; other site 59919002072 structural Zn2+ binding site [ion binding]; other site 59919002073 radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167 59919002074 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 59919002075 FeS/SAM binding site; other site 59919002076 Protein of unknown function (DUF3641); Region: DUF3641; pfam12345 59919002077 glucosylglycerol 3-phosphatase; Region: salt_tol_Pase; TIGR02399 59919002078 Glucosylglycerol-phosphate phosphatase (Salt_tol_Pase); Region: Salt_tol_Pase; pfam09506 59919002079 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 59919002080 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 59919002081 homodimer interface [polypeptide binding]; other site 59919002082 substrate-cofactor binding pocket; other site 59919002083 pyridoxal 5'-phosphate binding site [chemical binding]; other site 59919002084 catalytic residue [active] 59919002085 Homoserine O-succinyltransferase; Region: HTS; pfam04204 59919002086 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 59919002087 conserved cys residue [active] 59919002088 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 59919002089 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 59919002090 Sulfate transporter family; Region: Sulfate_transp; pfam00916 59919002091 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 59919002092 12 probable transmembrane helices predicted by TMHMM2.0 59919002093 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 59919002094 FAD binding domain; Region: FAD_binding_4; pfam01565 59919002095 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 59919002096 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 59919002097 putative active site [active] 59919002098 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 59919002099 putative active site [active] 59919002100 1 probable transmembrane helix predicted by TMHMM2.0 59919002101 Protein of unknown function (DUF2811); Region: DUF2811; pfam10929 59919002102 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 59919002103 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 59919002104 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 59919002105 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 59919002106 1 probable transmembrane helix predicted by TMHMM2.0 59919002107 Protein of unknown function (DUF3775); Region: DUF3775; pfam12616 59919002108 1 probable transmembrane helix predicted by TMHMM2.0 59919002109 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 59919002110 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 59919002111 dimer interface [polypeptide binding]; other site 59919002112 active site 59919002113 metal binding site [ion binding]; metal-binding site 59919002114 glutathione binding site [chemical binding]; other site 59919002115 4 probable transmembrane helices predicted by TMHMM2.0 59919002116 cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125 59919002117 5 probable transmembrane helices predicted by TMHMM2.0 59919002118 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 59919002119 S4 RNA-binding domain; Region: S4; smart00363 59919002120 RNA binding surface [nucleotide binding]; other site 59919002121 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 59919002122 probable active site [active] 59919002123 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 59919002124 nucleotide binding pocket [chemical binding]; other site 59919002125 K-X-D-G motif; other site 59919002126 catalytic site [active] 59919002127 Protein of unknown function (DUF1662); Region: DUF1662; pfam07878 59919002128 ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent; Region: RTPR; TIGR02505 59919002129 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 59919002130 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 59919002131 S-adenosylmethionine binding site [chemical binding]; other site 59919002132 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 59919002133 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 59919002134 G1 box; other site 59919002135 putative GEF interaction site [polypeptide binding]; other site 59919002136 GTP/Mg2+ binding site [chemical binding]; other site 59919002137 Switch I region; other site 59919002138 G2 box; other site 59919002139 G3 box; other site 59919002140 Switch II region; other site 59919002141 G4 box; other site 59919002142 G5 box; other site 59919002143 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 59919002144 Protein of unknown function (DUF3353); Region: DUF3353; pfam11833 59919002145 2 probable transmembrane helices predicted by TMHMM2.0 59919002146 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 59919002147 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 59919002148 dimerization interface [polypeptide binding]; other site 59919002149 domain crossover interface; other site 59919002150 redox-dependent activation switch; other site 59919002151 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 59919002152 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 59919002153 Walker A/P-loop; other site 59919002154 ATP binding site [chemical binding]; other site 59919002155 Q-loop/lid; other site 59919002156 ABC transporter signature motif; other site 59919002157 Walker B; other site 59919002158 D-loop; other site 59919002159 H-loop/switch region; other site 59919002160 Protein of unknown function (DUF3531); Region: DUF3531; pfam12049 59919002161 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 59919002162 Integral membrane protein DUF92; Region: DUF92; pfam01940 59919002163 6 probable transmembrane helices predicted by TMHMM2.0 59919002164 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_3; cd01835 59919002165 active site 59919002166 catalytic triad [active] 59919002167 oxyanion hole [active] 59919002168 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 59919002169 12 probable transmembrane helices predicted by TMHMM2.0 59919002170 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 59919002171 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 59919002172 Walker A/P-loop; other site 59919002173 ATP binding site [chemical binding]; other site 59919002174 Q-loop/lid; other site 59919002175 ABC transporter signature motif; other site 59919002176 Walker B; other site 59919002177 D-loop; other site 59919002178 H-loop/switch region; other site 59919002179 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 59919002180 aspartate aminotransferase; Provisional; Region: PRK05764 59919002181 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 59919002182 pyridoxal 5'-phosphate binding site [chemical binding]; other site 59919002183 homodimer interface [polypeptide binding]; other site 59919002184 catalytic residue [active] 59919002185 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 59919002186 active site 59919002187 Fe-S cluster binding site [ion binding]; other site 59919002188 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 59919002189 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 59919002190 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 59919002191 C-terminal peptidase (prc); Region: prc; TIGR00225 59919002192 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 59919002193 protein binding site [polypeptide binding]; other site 59919002194 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 59919002195 Catalytic dyad [active] 59919002196 quinolinate synthetase; Provisional; Region: PRK09375 59919002197 Myxococcus xanthus DevT and related proteins, metallophosphatase domain; Region: MPP_DevT; cd07397 59919002198 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 59919002199 putative active site [active] 59919002200 putative metal binding site [ion binding]; other site 59919002201 Repair protein; Region: Repair_PSII; pfam04536 59919002202 4 probable transmembrane helices predicted by TMHMM2.0 59919002203 Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636 59919002204 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 59919002205 active site 59919002206 dimer interface [polypeptide binding]; other site 59919002207 metal binding site [ion binding]; metal-binding site 59919002208 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 59919002209 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 59919002210 ATP-grasp domain; Region: ATP-grasp; pfam02222 59919002211 Protein of unknown function (DUF1651); Region: DUF1651; pfam07864 59919002212 1 probable transmembrane helix predicted by TMHMM2.0 59919002213 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 59919002214 Protein of unknown function (DUF3804); Region: DUF3804; pfam12707 59919002215 Chlorophyll A-B binding protein; Region: Chloroa_b-bind; pfam00504 59919002216 2 probable transmembrane helices predicted by TMHMM2.0 59919002217 putative high light inducible protein; Region: PHA02337 59919002218 Tryptophan-rich protein (DUF2389); Region: DUF2389; pfam09493 59919002219 Bunyavirus glycoprotein G1; Region: Bunya_G1; pfam03557 59919002220 C factor cell-cell signaling protein; Provisional; Region: PRK09009 59919002221 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 59919002222 NADP binding site [chemical binding]; other site 59919002223 homodimer interface [polypeptide binding]; other site 59919002224 active site 59919002225 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 59919002226 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 59919002227 catalytic triad [active] 59919002228 2 probable transmembrane helices predicted by TMHMM2.0 59919002229 1 probable transmembrane helix predicted by TMHMM2.0 59919002230 Protein of unknown function (DUF3303); Region: DUF3303; pfam11746 59919002231 2 probable transmembrane helices predicted by TMHMM2.0 59919002232 Protein of unknown function (DUF1499); Region: DUF1499; pfam07386 59919002233 Ion channel; Region: Ion_trans_2; pfam07885 59919002234 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 59919002235 TrkA-N domain; Region: TrkA_N; pfam02254 59919002236 TrkA-C domain; Region: TrkA_C; pfam02080 59919002237 3 probable transmembrane helices predicted by TMHMM2.0 59919002238 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 59919002239 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 59919002240 active site 59919002241 phosphorylation site [posttranslational modification] 59919002242 intermolecular recognition site; other site 59919002243 dimerization interface [polypeptide binding]; other site 59919002244 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 59919002245 DNA binding site [nucleotide binding] 59919002246 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 59919002247 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 59919002248 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 59919002249 dimer interface [polypeptide binding]; other site 59919002250 phosphorylation site [posttranslational modification] 59919002251 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 59919002252 ATP binding site [chemical binding]; other site 59919002253 Mg2+ binding site [ion binding]; other site 59919002254 G-X-G motif; other site 59919002255 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 59919002256 1 probable transmembrane helix predicted by TMHMM2.0 59919002257 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 59919002258 PBP superfamily domain; Region: PBP_like_2; cl17296 59919002259 Chromate transporter; Region: Chromate_transp; pfam02417 59919002260 Chromate transporter; Region: Chromate_transp; pfam02417 59919002261 11 probable transmembrane helices predicted by TMHMM2.0 59919002262 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 59919002263 putative substrate translocation pore; other site 59919002264 Major Facilitator Superfamily; Region: MFS_1; pfam07690 59919002265 11 probable transmembrane helices predicted by TMHMM2.0 59919002266 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK08955 59919002267 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 59919002268 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 59919002269 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 59919002270 dimerization interface [polypeptide binding]; other site 59919002271 putative DNA binding site [nucleotide binding]; other site 59919002272 putative Zn2+ binding site [ion binding]; other site 59919002273 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 59919002274 Sodium Bile acid symporter family; Region: SBF; cl17470 59919002275 9 probable transmembrane helices predicted by TMHMM2.0 59919002276 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 59919002277 1 probable transmembrane helix predicted by TMHMM2.0 59919002278 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 59919002279 Protein of unknown function (DUF3764); Region: DUF3764; pfam12594 59919002280 1 probable transmembrane helix predicted by TMHMM2.0 59919002281 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 59919002282 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 59919002283 dimer interface [polypeptide binding]; other site 59919002284 conserved gate region; other site 59919002285 putative PBP binding loops; other site 59919002286 ABC-ATPase subunit interface; other site 59919002287 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 59919002288 8 probable transmembrane helices predicted by TMHMM2.0 59919002289 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 59919002290 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 59919002291 dimer interface [polypeptide binding]; other site 59919002292 conserved gate region; other site 59919002293 putative PBP binding loops; other site 59919002294 ABC-ATPase subunit interface; other site 59919002295 6 probable transmembrane helices predicted by TMHMM2.0 59919002296 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14259 59919002297 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 59919002298 Walker A/P-loop; other site 59919002299 ATP binding site [chemical binding]; other site 59919002300 Q-loop/lid; other site 59919002301 ABC transporter signature motif; other site 59919002302 Walker B; other site 59919002303 D-loop; other site 59919002304 H-loop/switch region; other site 59919002305 Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391 59919002306 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 59919002307 putative active site [active] 59919002308 putative metal binding site [ion binding]; other site 59919002309 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 59919002310 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 59919002311 ATP binding site [chemical binding]; other site 59919002312 putative Mg++ binding site [ion binding]; other site 59919002313 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 59919002314 nucleotide binding region [chemical binding]; other site 59919002315 ATP-binding site [chemical binding]; other site 59919002316 DEAD/H associated; Region: DEAD_assoc; pfam08494 59919002317 ATP-dependent DNA ligase; Validated; Region: PRK09247 59919002318 Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897 59919002319 active site 59919002320 DNA binding site [nucleotide binding] 59919002321 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 59919002322 DNA binding site [nucleotide binding] 59919002323 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 59919002324 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 59919002325 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 59919002326 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 59919002327 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 59919002328 1 probable transmembrane helix predicted by TMHMM2.0 59919002329 Predicted metal-binding protein (DUF2103); Region: DUF2103; cl01651 59919002330 cytochrome b6-f complex subunit PetN; Provisional; Region: petN; PRK02529 59919002331 1 probable transmembrane helix predicted by TMHMM2.0 59919002332 Thf1-like protein; Reviewed; Region: PRK13266 59919002333 photosystem II biogenesis protein Psp29; Region: PS_II_psb29; TIGR03060 59919002334 Clp protease; Region: CLP_protease; pfam00574 59919002335 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 59919002336 oligomer interface [polypeptide binding]; other site 59919002337 active site residues [active] 59919002338 cell division protein; Validated; Region: ftsH; CHL00176 59919002339 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 59919002340 Walker A motif; other site 59919002341 ATP binding site [chemical binding]; other site 59919002342 Walker B motif; other site 59919002343 arginine finger; other site 59919002344 Peptidase family M41; Region: Peptidase_M41; pfam01434 59919002345 1 probable transmembrane helix predicted by TMHMM2.0 59919002346 Protein of unknown function (DUF3148); Region: DUF3148; pfam11347 59919002347 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 59919002348 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 59919002349 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 59919002350 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 59919002351 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 59919002352 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 59919002353 phycocyanobilin:ferredoxin oxidoreductase; Validated; Region: PRK02816 59919002354 Peptidase family M23; Region: Peptidase_M23; pfam01551 59919002355 HlyD family secretion protein; Region: HlyD_3; pfam13437 59919002356 1 probable transmembrane helix predicted by TMHMM2.0 59919002357 DevC protein; Region: devC; TIGR01185 59919002358 FtsX-like permease family; Region: FtsX; pfam02687 59919002359 4 probable transmembrane helices predicted by TMHMM2.0 59919002360 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 59919002361 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 59919002362 Walker A/P-loop; other site 59919002363 ATP binding site [chemical binding]; other site 59919002364 Q-loop/lid; other site 59919002365 ABC transporter signature motif; other site 59919002366 Walker B; other site 59919002367 D-loop; other site 59919002368 H-loop/switch region; other site 59919002369 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 59919002370 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 59919002371 active site 59919002372 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 59919002373 rRNA interaction site [nucleotide binding]; other site 59919002374 S8 interaction site; other site 59919002375 putative laminin-1 binding site; other site 59919002376 elongation factor Ts; Reviewed; Region: tsf; PRK12332 59919002377 UBA/TS-N domain; Region: UBA; pfam00627 59919002378 Elongation factor TS; Region: EF_TS; pfam00889 59919002379 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 59919002380 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 59919002381 ssDNA binding site; other site 59919002382 generic binding surface II; other site 59919002383 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 59919002384 ATP binding site [chemical binding]; other site 59919002385 putative Mg++ binding site [ion binding]; other site 59919002386 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 59919002387 nucleotide binding region [chemical binding]; other site 59919002388 ATP-binding site [chemical binding]; other site 59919002389 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 59919002390 sulfite reductase subunit beta; Provisional; Region: PRK13504 59919002391 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 59919002392 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 59919002393 Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092 59919002394 geranylgeranyl reductase; Region: ChlP; TIGR02028 59919002395 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 59919002396 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 59919002397 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 59919002398 1 probable transmembrane helix predicted by TMHMM2.0 59919002399 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 59919002400 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 59919002401 G1 box; other site 59919002402 putative GEF interaction site [polypeptide binding]; other site 59919002403 GTP/Mg2+ binding site [chemical binding]; other site 59919002404 Switch I region; other site 59919002405 G2 box; other site 59919002406 G3 box; other site 59919002407 Switch II region; other site 59919002408 G4 box; other site 59919002409 G5 box; other site 59919002410 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 59919002411 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 59919002412 Domain of unknown function (DUF309); Region: DUF309; pfam03745 59919002413 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 59919002414 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 59919002415 Walker A/P-loop; other site 59919002416 ATP binding site [chemical binding]; other site 59919002417 Q-loop/lid; other site 59919002418 ABC transporter signature motif; other site 59919002419 Walker B; other site 59919002420 D-loop; other site 59919002421 H-loop/switch region; other site 59919002422 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 59919002423 8 probable transmembrane helices predicted by TMHMM2.0 59919002424 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 59919002425 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 59919002426 substrate binding site [chemical binding]; other site 59919002427 hexamer interface [polypeptide binding]; other site 59919002428 metal binding site [ion binding]; metal-binding site 59919002429 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 59919002430 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 59919002431 putative active site [active] 59919002432 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 59919002433 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 59919002434 tRNA; other site 59919002435 putative tRNA binding site [nucleotide binding]; other site 59919002436 putative NADP binding site [chemical binding]; other site 59919002437 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 59919002438 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862 59919002439 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 59919002440 ligand binding site; other site 59919002441 oligomer interface; other site 59919002442 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 59919002443 dimer interface [polypeptide binding]; other site 59919002444 N-terminal domain interface [polypeptide binding]; other site 59919002445 sulfate 1 binding site; other site 59919002446 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 59919002447 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 59919002448 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 59919002449 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 59919002450 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 59919002451 putative active site [active] 59919002452 Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547 59919002453 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 59919002454 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 59919002455 1 probable transmembrane helix predicted by TMHMM2.0 59919002456 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 59919002457 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 59919002458 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 59919002459 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 59919002460 1 probable transmembrane helix predicted by TMHMM2.0 59919002461 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 59919002462 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 59919002463 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 59919002464 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 59919002465 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 59919002466 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 59919002467 putative active site [active] 59919002468 catalytic triad [active] 59919002469 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 59919002470 intersubunit interface [polypeptide binding]; other site 59919002471 active site 59919002472 zinc binding site [ion binding]; other site 59919002473 Na+ binding site [ion binding]; other site 59919002474 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 59919002475 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 59919002476 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 59919002477 1 probable transmembrane helix predicted by TMHMM2.0 59919002478 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 59919002479 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 59919002480 Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029 59919002481 active site 59919002482 tartrate dehydrogenase; Region: TTC; TIGR02089 59919002483 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 59919002484 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 59919002485 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 59919002486 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 59919002487 trimer interface [polypeptide binding]; other site 59919002488 active site 59919002489 UDP-GlcNAc binding site [chemical binding]; other site 59919002490 lipid binding site [chemical binding]; lipid-binding site 59919002491 gamma-glutamyl kinase; Provisional; Region: PRK05429 59919002492 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 59919002493 nucleotide binding site [chemical binding]; other site 59919002494 homotetrameric interface [polypeptide binding]; other site 59919002495 putative phosphate binding site [ion binding]; other site 59919002496 putative allosteric binding site; other site 59919002497 PUA domain; Region: PUA; pfam01472 59919002498 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 59919002499 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 59919002500 active site 59919002501 motif I; other site 59919002502 motif II; other site 59919002503 Protein of unknown function (DUF1292); Region: DUF1292; pfam06949 59919002504 Protein of unknown function (DUF3727); Region: DUF3727; pfam12527 59919002505 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 59919002506 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996 59919002507 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 59919002508 Protein of unknown function (DUF3685); Region: DUF3685; pfam12452 59919002509 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 59919002510 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 59919002511 catalytic residues [active] 59919002512 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 59919002513 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 59919002514 NAD(P) binding site [chemical binding]; other site 59919002515 active site 59919002516 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 59919002517 5 probable transmembrane helices predicted by TMHMM2.0 59919002518 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 59919002519 trimer interface [polypeptide binding]; other site 59919002520 putative Zn binding site [ion binding]; other site 59919002521 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 59919002522 GSH binding site [chemical binding]; other site 59919002523 catalytic residues [active] 59919002524 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 59919002525 NADH(P)-binding; Region: NAD_binding_10; pfam13460 59919002526 NAD(P) binding site [chemical binding]; other site 59919002527 putative active site [active] 59919002528 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 59919002529 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 59919002530 minor groove reading motif; other site 59919002531 helix-hairpin-helix signature motif; other site 59919002532 substrate binding pocket [chemical binding]; other site 59919002533 active site 59919002534 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 59919002535 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 59919002536 Walker A/P-loop; other site 59919002537 ATP binding site [chemical binding]; other site 59919002538 Q-loop/lid; other site 59919002539 ABC transporter signature motif; other site 59919002540 Walker B; other site 59919002541 D-loop; other site 59919002542 H-loop/switch region; other site 59919002543 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 59919002544 Ferritin-like domain; Region: Ferritin; pfam00210 59919002545 ferroxidase diiron center [ion binding]; other site 59919002546 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 59919002547 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 59919002548 putative switch regulator; other site 59919002549 non-specific DNA interactions [nucleotide binding]; other site 59919002550 DNA binding site [nucleotide binding] 59919002551 sequence specific DNA binding site [nucleotide binding]; other site 59919002552 putative cAMP binding site [chemical binding]; other site 59919002553 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 59919002554 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 59919002555 Walker A/P-loop; other site 59919002556 ATP binding site [chemical binding]; other site 59919002557 Q-loop/lid; other site 59919002558 ABC transporter signature motif; other site 59919002559 Walker B; other site 59919002560 D-loop; other site 59919002561 H-loop/switch region; other site 59919002562 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 59919002563 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 59919002564 [2Fe-2S] cluster binding site [ion binding]; other site 59919002565 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 59919002566 1 probable transmembrane helix predicted by TMHMM2.0 59919002567 putative high light inducible protein; Region: PHA02337 59919002568 putative high light inducible protein; Region: PHA02337 59919002569 2 probable transmembrane helices predicted by TMHMM2.0 59919002570 putative high light inducible protein; Region: PHA02337 59919002571 1 probable transmembrane helix predicted by TMHMM2.0 59919002572 putative high light inducible protein; Region: PHA02337 59919002573 1 probable transmembrane helix predicted by TMHMM2.0 59919002574 Protein of unknown function (DUF1651); Region: DUF1651; pfam07864 59919002575 L-asparaginase II; Region: Asparaginase_II; pfam06089 59919002576 Protein of unknown function (DUF1230); Region: DUF1230; pfam06799 59919002577 3 probable transmembrane helices predicted by TMHMM2.0 59919002578 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 59919002579 Protein of unknown function (DUF3318); Region: DUF3318; pfam11780 59919002580 1 probable transmembrane helix predicted by TMHMM2.0 59919002581 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 59919002582 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 59919002583 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 59919002584 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 59919002585 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 59919002586 ATP-grasp domain; Region: ATP-grasp_4; cl17255 59919002587 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 59919002588 IMP binding site; other site 59919002589 dimer interface [polypeptide binding]; other site 59919002590 interdomain contacts; other site 59919002591 partial ornithine binding site; other site 59919002592 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 59919002593 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 59919002594 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 59919002595 Walker A/P-loop; other site 59919002596 ATP binding site [chemical binding]; other site 59919002597 Q-loop/lid; other site 59919002598 ABC transporter signature motif; other site 59919002599 Walker B; other site 59919002600 D-loop; other site 59919002601 H-loop/switch region; other site 59919002602 5 probable transmembrane helices predicted by TMHMM2.0 59919002603 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 59919002604 RNA binding surface [nucleotide binding]; other site 59919002605 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 59919002606 triosephosphate isomerase; Provisional; Region: PRK14565 59919002607 substrate binding site [chemical binding]; other site 59919002608 dimer interface [polypeptide binding]; other site 59919002609 catalytic triad [active] 59919002610 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 59919002611 dihydropteroate synthase; Region: DHPS; TIGR01496 59919002612 substrate binding pocket [chemical binding]; other site 59919002613 dimer interface [polypeptide binding]; other site 59919002614 inhibitor binding site; inhibition site 59919002615 magnesium chelatase subunit H; Provisional; Region: PRK12493 59919002616 Domain of unknown function (DUF3479); Region: DUF3479; pfam11965 59919002617 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 59919002618 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 59919002619 dihydrodipicolinate reductase; Provisional; Region: PRK00048 59919002620 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 59919002621 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 59919002622 2 probable transmembrane helices predicted by TMHMM2.0 59919002623 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 59919002624 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 59919002625 Protein of unknown function (DUF2949); Region: DUF2949; pfam11165 59919002626 Protein of unknown function (DUF3038); Region: DUF3038; pfam11237 59919002627 Domain of unknown function (DUF4335); Region: DUF4335; pfam14233 59919002628 1 probable transmembrane helix predicted by TMHMM2.0 59919002629 2 probable transmembrane helices predicted by TMHMM2.0 59919002630 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 59919002631 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 59919002632 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 59919002633 ATP binding site [chemical binding]; other site 59919002634 putative Mg++ binding site [ion binding]; other site 59919002635 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 59919002636 nucleotide binding region [chemical binding]; other site 59919002637 ATP-binding site [chemical binding]; other site 59919002638 TRCF domain; Region: TRCF; pfam03461 59919002639 Integral membrane protein TerC family; Region: TerC; cl10468 59919002640 7 probable transmembrane helices predicted by TMHMM2.0 59919002641 Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223 59919002642 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 59919002643 putative active site [active] 59919002644 substrate binding site [chemical binding]; other site 59919002645 putative cosubstrate binding site; other site 59919002646 catalytic site [active] 59919002647 Carboxy-terminal domain of Formyltransferase and similar domains; Region: FMT_C_like; cl14785 59919002648 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 59919002649 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 59919002650 Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047 59919002651 diiron binding motif [ion binding]; other site 59919002652 Protein of unknown function (DUF2996); Region: DUF2996; pfam11210 59919002653 2 probable transmembrane helices predicted by TMHMM2.0 59919002654 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 59919002655 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 59919002656 RNB domain; Region: RNB; pfam00773 59919002657 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 59919002658 RNA binding site [nucleotide binding]; other site 59919002659 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 59919002660 3 probable transmembrane helices predicted by TMHMM2.0 59919002661 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 59919002662 3 probable transmembrane helices predicted by TMHMM2.0 59919002663 Flagellin N-methylase; Region: FliB; pfam03692 59919002664 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 59919002665 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 59919002666 motif II; other site 59919002667 2 probable transmembrane helices predicted by TMHMM2.0 59919002668 ribosomal protein L32; Validated; Region: rpl32; CHL00152 59919002669 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 59919002670 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 59919002671 Walker A motif; other site 59919002672 ATP binding site [chemical binding]; other site 59919002673 Walker B motif; other site 59919002674 arginine finger; other site 59919002675 Peptidase family M41; Region: Peptidase_M41; pfam01434 59919002676 1 probable transmembrane helix predicted by TMHMM2.0 59919002677 6 probable transmembrane helices predicted by TMHMM2.0 59919002678 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 59919002679 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 59919002680 dimer interface [polypeptide binding]; other site 59919002681 decamer (pentamer of dimers) interface [polypeptide binding]; other site 59919002682 catalytic triad [active] 59919002683 peroxidatic and resolving cysteines [active] 59919002684 Protein of unknown function (DUF1651); Region: DUF1651; pfam07864 59919002685 Protein of unknown function (DUF1651); Region: DUF1651; pfam07864 59919002686 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 59919002687 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 59919002688 homotrimer interface [polypeptide binding]; other site 59919002689 Walker A motif; other site 59919002690 GTP binding site [chemical binding]; other site 59919002691 Walker B motif; other site 59919002692 2 probable transmembrane helices predicted by TMHMM2.0 59919002693 Protein of unknown function (DUF2930); Region: DUF2930; pfam11152 59919002694 2 probable transmembrane helices predicted by TMHMM2.0 59919002695 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 59919002696 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 59919002697 active site 59919002698 HIGH motif; other site 59919002699 KMSKS motif; other site 59919002700 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 59919002701 tRNA binding surface [nucleotide binding]; other site 59919002702 anticodon binding site; other site 59919002703 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 59919002704 RNB domain; Region: RNB; pfam00773 59919002705 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 59919002706 ribosomal protein L33; Region: rpl33; CHL00104 59919002707 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 59919002708 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 59919002709 putative tRNA-binding site [nucleotide binding]; other site 59919002710 B3/4 domain; Region: B3_4; pfam03483 59919002711 tRNA synthetase B5 domain; Region: B5; smart00874 59919002712 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 59919002713 dimer interface [polypeptide binding]; other site 59919002714 motif 1; other site 59919002715 motif 3; other site 59919002716 motif 2; other site 59919002717 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 59919002718 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 59919002719 HSP70 interaction site [polypeptide binding]; other site 59919002720 ATP adenylyltransferase (5',5'''-P-1,P-4-tetraphosphate phosphorylase II) [Nucleotide transport and metabolism]; Region: APA2; COG4360 59919002721 ATP adenylyltransferase; Region: ATP_transf; pfam09830 59919002722 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996 59919002723 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 59919002724 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 59919002725 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 59919002726 substrate binding pocket [chemical binding]; other site 59919002727 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 59919002728 B12 binding site [chemical binding]; other site 59919002729 cobalt ligand [ion binding]; other site 59919002730 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 59919002731 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 59919002732 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 59919002733 homodimer interface [polypeptide binding]; other site 59919002734 substrate-cofactor binding pocket; other site 59919002735 catalytic residue [active] 59919002736 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 59919002737 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 59919002738 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 59919002739 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 59919002740 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 59919002741 active site 59919002742 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 59919002743 5 probable transmembrane helices predicted by TMHMM2.0 59919002744 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 59919002745 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 59919002746 GIY-YIG motif/motif A; other site 59919002747 active site 59919002748 catalytic site [active] 59919002749 putative DNA binding site [nucleotide binding]; other site 59919002750 metal binding site [ion binding]; metal-binding site 59919002751 UvrB/uvrC motif; Region: UVR; pfam02151 59919002752 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 59919002753 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 59919002754 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 59919002755 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 59919002756 active site 59919002757 (T/H)XGH motif; other site 59919002758 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 59919002759 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 59919002760 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 59919002761 Domain of unknown function (DUF1995); Region: DUF1995; pfam09353 59919002762 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 59919002763 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 59919002764 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 59919002765 catalytic residue [active] 59919002766 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 59919002767 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 59919002768 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 59919002769 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 59919002770 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 59919002771 HIGH motif; other site 59919002772 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 59919002773 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 59919002774 active site 59919002775 KMSKS motif; other site 59919002776 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 59919002777 tRNA binding surface [nucleotide binding]; other site 59919002778 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14096 59919002779 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 59919002780 active site 59919002781 dimer interface [polypeptide binding]; other site 59919002782 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 59919002783 dimer interface [polypeptide binding]; other site 59919002784 active site 59919002785 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 59919002786 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 59919002787 active site 59919002788 substrate binding site [chemical binding]; other site 59919002789 cosubstrate binding site; other site 59919002790 catalytic site [active] 59919002791 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 59919002792 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 59919002793 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II/unknown domain fusion protein; Provisional; Region: PRK09319 59919002794 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 59919002795 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 59919002796 dimerization interface [polypeptide binding]; other site 59919002797 active site 59919002798 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 59919002799 active site 59919002800 Protein of unknown function (DUF3110); Region: DUF3110; pfam11360 59919002801 chaperone protein DnaJ; Provisional; Region: PRK14299 59919002802 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 59919002803 HSP70 interaction site [polypeptide binding]; other site 59919002804 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 59919002805 substrate binding site [polypeptide binding]; other site 59919002806 dimer interface [polypeptide binding]; other site 59919002807 molecular chaperone DnaK; Provisional; Region: PRK13410 59919002808 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 59919002809 nucleotide binding site [chemical binding]; other site 59919002810 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 59919002811 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 59919002812 catalytic loop [active] 59919002813 iron binding site [ion binding]; other site 59919002814 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 59919002815 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 59919002816 active site 59919002817 dimerization interface [polypeptide binding]; other site 59919002818 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 59919002819 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 59919002820 motif 1; other site 59919002821 dimer interface [polypeptide binding]; other site 59919002822 active site 59919002823 motif 2; other site 59919002824 motif 3; other site 59919002825 heat shock protein 90; Provisional; Region: PRK05218 59919002826 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 59919002827 ATP binding site [chemical binding]; other site 59919002828 Mg2+ binding site [ion binding]; other site 59919002829 G-X-G motif; other site 59919002830 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 59919002831 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 59919002832 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 59919002833 catalytic triad [active] 59919002834 1 probable transmembrane helix predicted by TMHMM2.0 59919002835 Protein of unknown function (DUF2499); Region: DUF2499; pfam10693 59919002836 3 probable transmembrane helices predicted by TMHMM2.0 59919002837 Protein of unknown function (DUF3593); Region: DUF3593; pfam12159 59919002838 3 probable transmembrane helices predicted by TMHMM2.0 59919002839 photosystem I reaction center subunit PsaK; Region: PS_I_psaK; TIGR03049 59919002840 2 probable transmembrane helices predicted by TMHMM2.0 59919002841 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 59919002842 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 59919002843 TPP-binding site; other site 59919002844 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 59919002845 PYR/PP interface [polypeptide binding]; other site 59919002846 dimer interface [polypeptide binding]; other site 59919002847 TPP binding site [chemical binding]; other site 59919002848 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 59919002849 threonine dehydratase; Reviewed; Region: PRK09224 59919002850 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 59919002851 tetramer interface [polypeptide binding]; other site 59919002852 pyridoxal 5'-phosphate binding site [chemical binding]; other site 59919002853 catalytic residue [active] 59919002854 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 59919002855 putative Ile/Val binding site [chemical binding]; other site 59919002856 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 59919002857 putative Ile/Val binding site [chemical binding]; other site 59919002858 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 59919002859 YGGT family; Region: YGGT; pfam02325 59919002860 2 probable transmembrane helices predicted by TMHMM2.0 59919002861 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 59919002862 putative metal binding site [ion binding]; other site 59919002863 pyruvate kinase; Provisional; Region: PRK06354 59919002864 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 59919002865 domain interfaces; other site 59919002866 active site 59919002867 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700 59919002868 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 59919002869 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 59919002870 FtsX-like permease family; Region: FtsX; pfam02687 59919002871 4 probable transmembrane helices predicted by TMHMM2.0 59919002872 BioY family; Region: BioY; pfam02632 59919002873 5 probable transmembrane helices predicted by TMHMM2.0 59919002874 lipoprotein signal peptidase; Provisional; Region: PRK14792 59919002875 4 probable transmembrane helices predicted by TMHMM2.0 59919002876 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 59919002877 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 59919002878 G1 box; other site 59919002879 GTP/Mg2+ binding site [chemical binding]; other site 59919002880 Switch I region; other site 59919002881 G2 box; other site 59919002882 Switch II region; other site 59919002883 G3 box; other site 59919002884 G4 box; other site 59919002885 G5 box; other site 59919002886 Domain of unknown function (DUF697); Region: DUF697; pfam05128 59919002887 1 probable transmembrane helix predicted by TMHMM2.0 59919002888 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 59919002889 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 59919002890 catalytic residue [active] 59919002891 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 59919002892 nucleoside/Zn binding site; other site 59919002893 dimer interface [polypeptide binding]; other site 59919002894 catalytic motif [active] 59919002895 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 59919002896 homodimer interface [polypeptide binding]; other site 59919002897 pyridoxal 5'-phosphate binding site [chemical binding]; other site 59919002898 catalytic residue [active] 59919002899 glutamine synthetase, type I; Region: GlnA; TIGR00653 59919002900 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 59919002901 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 59919002902 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 59919002903 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 59919002904 S-adenosylmethionine binding site [chemical binding]; other site 59919002905 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 59919002906 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 59919002907 GUN4-like; Region: GUN4; pfam05419 59919002908 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 59919002909 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 59919002910 active site residue [active] 59919002911 photosystem II reaction center protein Psb28; Provisional; Region: PRK13612 59919002912 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 59919002913 Domain of unknown function DUF20; Region: UPF0118; pfam01594 59919002914 8 probable transmembrane helices predicted by TMHMM2.0 59919002915 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 59919002916 Protein export membrane protein; Region: SecD_SecF; cl14618 59919002917 5 probable transmembrane helices predicted by TMHMM2.0 59919002918 protein-export membrane protein SecD; Region: secD; TIGR01129 59919002919 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 59919002920 6 probable transmembrane helices predicted by TMHMM2.0 59919002921 pyruvate dehydrogenase E1 component beta subunit; Validated; Region: odpB; CHL00144 59919002922 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 59919002923 alpha subunit interface [polypeptide binding]; other site 59919002924 TPP binding site [chemical binding]; other site 59919002925 heterodimer interface [polypeptide binding]; other site 59919002926 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 59919002927 Protein of unknown function (DUF3082); Region: DUF3082; pfam11282 59919002928 2 probable transmembrane helices predicted by TMHMM2.0 59919002929 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK02534 59919002930 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 59919002931 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 59919002932 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 59919002933 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 59919002934 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 59919002935 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 59919002936 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 59919002937 Catalytic site [active] 59919002938 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 59919002939 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 59919002940 active site 59919002941 DNA binding site [nucleotide binding] 59919002942 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 59919002943 DNA primase; Validated; Region: dnaG; PRK05667 59919002944 CHC2 zinc finger; Region: zf-CHC2; pfam01807 59919002945 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 59919002946 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 59919002947 active site 59919002948 metal binding site [ion binding]; metal-binding site 59919002949 interdomain interaction site; other site 59919002950 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 59919002951 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 59919002952 9 probable transmembrane helices predicted by TMHMM2.0 59919002953 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 59919002954 RuvA N terminal domain; Region: RuvA_N; pfam01330 59919002955 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 59919002956 16S/18S rRNA binding site [nucleotide binding]; other site 59919002957 S13e-L30e interaction site [polypeptide binding]; other site 59919002958 25S rRNA binding site [nucleotide binding]; other site 59919002959 Protein of unknown function (DUF3464); Region: DUF3464; pfam11947 59919002960 2 probable transmembrane helices predicted by TMHMM2.0 59919002961 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK07374 59919002962 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 59919002963 active site 59919002964 PHP Thumb interface [polypeptide binding]; other site 59919002965 metal binding site [ion binding]; metal-binding site 59919002966 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 59919002967 generic binding surface I; other site 59919002968 generic binding surface II; other site 59919002969 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 59919002970 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 59919002971 Domain of unknown function (DUF1816); Region: DUF1816; pfam08846 59919002972 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 59919002973 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 59919002974 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 59919002975 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cl00258 59919002976 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 59919002977 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 59919002978 anti sigma factor interaction site; other site 59919002979 regulatory phosphorylation site [posttranslational modification]; other site 59919002980 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 59919002981 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 59919002982 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 59919002983 catalytic site [active] 59919002984 subunit interface [polypeptide binding]; other site 59919002985 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 59919002986 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 59919002987 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 59919002988 Protein of unknown function (DUF3288); Region: DUF3288; pfam11691 59919002989 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 59919002990 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 59919002991 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 59919002992 Walker A/P-loop; other site 59919002993 ATP binding site [chemical binding]; other site 59919002994 Q-loop/lid; other site 59919002995 ABC transporter signature motif; other site 59919002996 Walker B; other site 59919002997 D-loop; other site 59919002998 H-loop/switch region; other site 59919002999 6 probable transmembrane helices predicted by TMHMM2.0 59919003000 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 59919003001 Bacitracin resistance protein BacA; Region: BacA; pfam02673 59919003002 6 probable transmembrane helices predicted by TMHMM2.0 59919003003 Domain of unknown function (DUF1830); Region: DUF1830; pfam08865 59919003004 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 59919003005 active site 59919003006 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK00192 59919003007 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 59919003008 active site 59919003009 motif I; other site 59919003010 motif II; other site 59919003011 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 59919003012 active site 59919003013 homodimer interface [polypeptide binding]; other site 59919003014 catalytic site [active] 59919003015 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 59919003016 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 59919003017 urease subunit alpha; Reviewed; Region: ureC; PRK13207 59919003018 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 59919003019 subunit interactions [polypeptide binding]; other site 59919003020 active site 59919003021 flap region; other site 59919003022 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 59919003023 gamma-beta subunit interface [polypeptide binding]; other site 59919003024 alpha-beta subunit interface [polypeptide binding]; other site 59919003025 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 59919003026 alpha-gamma subunit interface [polypeptide binding]; other site 59919003027 beta-gamma subunit interface [polypeptide binding]; other site 59919003028 UreD urease accessory protein; Region: UreD; pfam01774 59919003029 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 59919003030 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 59919003031 dimer interface [polypeptide binding]; other site 59919003032 catalytic residues [active] 59919003033 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 59919003034 UreF; Region: UreF; pfam01730 59919003035 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 59919003036 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 59919003037 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 59919003038 putative ligand binding site [chemical binding]; other site 59919003039 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 59919003040 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 59919003041 TM-ABC transporter signature motif; other site 59919003042 8 probable transmembrane helices predicted by TMHMM2.0 59919003043 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 59919003044 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 59919003045 TM-ABC transporter signature motif; other site 59919003046 9 probable transmembrane helices predicted by TMHMM2.0 59919003047 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 59919003048 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 59919003049 Walker A/P-loop; other site 59919003050 ATP binding site [chemical binding]; other site 59919003051 Q-loop/lid; other site 59919003052 ABC transporter signature motif; other site 59919003053 Walker B; other site 59919003054 D-loop; other site 59919003055 H-loop/switch region; other site 59919003056 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 59919003057 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 59919003058 Walker A/P-loop; other site 59919003059 ATP binding site [chemical binding]; other site 59919003060 Q-loop/lid; other site 59919003061 ABC transporter signature motif; other site 59919003062 Walker B; other site 59919003063 D-loop; other site 59919003064 H-loop/switch region; other site 59919003065 Protein of unknown function (DUF2862); Region: DUF2862; pfam11061 59919003066 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 59919003067 ATP-binding cassette domain of an uncharacterized transporter similar in sequence to NatA; Region: ABC_NatA_like; cd03267 59919003068 Walker A/P-loop; other site 59919003069 ATP binding site [chemical binding]; other site 59919003070 Q-loop/lid; other site 59919003071 ABC transporter signature motif; other site 59919003072 Walker B; other site 59919003073 D-loop; other site 59919003074 H-loop/switch region; other site 59919003075 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 59919003076 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 59919003077 6 probable transmembrane helices predicted by TMHMM2.0 59919003078 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 59919003079 6 probable transmembrane helices predicted by TMHMM2.0 59919003080 1 probable transmembrane helix predicted by TMHMM2.0 59919003081 hypothetical protein; Provisional; Region: PRK10621 59919003082 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 59919003083 7 probable transmembrane helices predicted by TMHMM2.0 59919003084 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 59919003085 active site 59919003086 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 59919003087 active site 59919003088 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 59919003089 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 59919003090 ski2-like helicase; Provisional; Region: PRK00254 59919003091 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 59919003092 AAA domain; Region: AAA_18; pfam13238 59919003093 active site 59919003094 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 59919003095 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 59919003096 active site pocket [active] 59919003097 oxyanion hole [active] 59919003098 catalytic triad [active] 59919003099 active site nucleophile [active] 59919003100 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 59919003101 3 probable transmembrane helices predicted by TMHMM2.0 59919003102 Protein of unknown function (DUF3303); Region: DUF3303; pfam11746 59919003103 2 probable transmembrane helices predicted by TMHMM2.0 59919003104 Protein of unknown function, DUF393; Region: DUF393; pfam04134 59919003105 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 59919003106 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 59919003107 aminopeptidase N; Provisional; Region: pepN; PRK14015 59919003108 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 59919003109 Zn binding site [ion binding]; other site 59919003110 1 probable transmembrane helix predicted by TMHMM2.0 59919003111 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 59919003112 ATP-grasp domain; Region: ATP-grasp; pfam02222 59919003113 1 probable transmembrane helix predicted by TMHMM2.0 59919003114 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 59919003115 catalytic residues [active] 59919003116 dimer interface [polypeptide binding]; other site 59919003117 1 probable transmembrane helix predicted by TMHMM2.0 59919003118 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 59919003119 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 59919003120 FMN binding site [chemical binding]; other site 59919003121 active site 59919003122 catalytic residues [active] 59919003123 substrate binding site [chemical binding]; other site 59919003124 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 59919003125 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 59919003126 active site 59919003127 Restriction endonuclease; Region: Mrr_cat; pfam04471 59919003128 1 probable transmembrane helix predicted by TMHMM2.0 59919003129 MAPEG family; Region: MAPEG; pfam01124 59919003130 2 probable transmembrane helices predicted by TMHMM2.0 59919003131 1 probable transmembrane helix predicted by TMHMM2.0 59919003132 PAP_fibrillin; Region: PAP_fibrillin; pfam04755 59919003133 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 59919003134 1 probable transmembrane helix predicted by TMHMM2.0 59919003135 Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862 59919003136 1 probable transmembrane helix predicted by TMHMM2.0 59919003137 3 probable transmembrane helices predicted by TMHMM2.0 59919003138 1 probable transmembrane helix predicted by TMHMM2.0 59919003139 OsmC-like protein; Region: OsmC; pfam02566 59919003140 Protein of unknown function (DUF1499); Region: DUF1499; pfam07386 59919003141 1 probable transmembrane helix predicted by TMHMM2.0 59919003142 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 59919003143 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 59919003144 ABC-ATPase subunit interface; other site 59919003145 dimer interface [polypeptide binding]; other site 59919003146 putative PBP binding regions; other site 59919003147 7 probable transmembrane helices predicted by TMHMM2.0 59919003148 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 59919003149 putative DNA binding helix; other site 59919003150 metal binding site 2 [ion binding]; metal-binding site 59919003151 metal binding site 1 [ion binding]; metal-binding site 59919003152 dimer interface [polypeptide binding]; other site 59919003153 structural Zn2+ binding site [ion binding]; other site 59919003154 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 59919003155 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 59919003156 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 59919003157 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 59919003158 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 59919003159 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 59919003160 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 59919003161 P-loop, Walker A motif; other site 59919003162 Base recognition motif; other site 59919003163 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 59919003164 PQQ-like domain; Region: PQQ_2; pfam13360 59919003165 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 59919003166 structural tetrad; other site 59919003167 1 probable transmembrane helix predicted by TMHMM2.0 59919003168 2 probable transmembrane helices predicted by TMHMM2.0 59919003169 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 59919003170 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 59919003171 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 59919003172 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 59919003173 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 59919003174 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 59919003175 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 59919003176 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 59919003177 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 59919003178 1 probable transmembrane helix predicted by TMHMM2.0 59919003179 1 probable transmembrane helix predicted by TMHMM2.0 59919003180 Guanosine kinase-like sugar kinases. Found in bacteria and archaea, the guanosine kinase-like group is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: Guanosine_kinase_like; cd01947 59919003181 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 59919003182 substrate binding site [chemical binding]; other site 59919003183 ATP binding site [chemical binding]; other site 59919003184 1 probable transmembrane helix predicted by TMHMM2.0 59919003185 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 59919003186 1 probable transmembrane helix predicted by TMHMM2.0 59919003187 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 59919003188 11 probable transmembrane helices predicted by TMHMM2.0 59919003189 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 59919003190 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 59919003191 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 59919003192 ABC-ATPase subunit interface; other site 59919003193 6 probable transmembrane helices predicted by TMHMM2.0 59919003194 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_20; cd08519 59919003195 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 59919003196 homoserine dehydrogenase; Provisional; Region: PRK06349 59919003197 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 59919003198 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 59919003199 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 59919003200 Fe-S metabolism associated domain; Region: SufE; cl00951 59919003201 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 59919003202 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 59919003203 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 59919003204 active site 59919003205 putative DNA-binding cleft [nucleotide binding]; other site 59919003206 dimer interface [polypeptide binding]; other site 59919003207 Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081 59919003208 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 59919003209 Walker A motif; other site 59919003210 ATP binding site [chemical binding]; other site 59919003211 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 59919003212 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 59919003213 Cytochrome c; Region: Cytochrom_C; pfam00034 59919003214 1 probable transmembrane helix predicted by TMHMM2.0 59919003215 cytochrome b6-f complex subunit PetG; Reviewed; Region: petG; PRK00665 59919003216 1 probable transmembrane helix predicted by TMHMM2.0 59919003217 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 59919003218 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 59919003219 S-adenosylmethionine binding site [chemical binding]; other site 59919003220 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 59919003221 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 59919003222 putative active site [active] 59919003223 oxyanion strand; other site 59919003224 catalytic triad [active] 59919003225 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 59919003226 catalytic residues [active] 59919003227 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 59919003228 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 59919003229 active site 59919003230 DNA gyrase subunit A; Validated; Region: PRK05560 59919003231 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 59919003232 CAP-like domain; other site 59919003233 active site 59919003234 primary dimer interface [polypeptide binding]; other site 59919003235 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 59919003236 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 59919003237 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 59919003238 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 59919003239 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 59919003240 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 59919003241 lycopene cyclase family protein; Region: carotene-cycl; TIGR01790 59919003242 lycopene cyclase; Region: lycopene_cycl; TIGR01789 59919003243 Uncharacterized conserved protein [Function unknown]; Region: COG1543 59919003244 N-terminal catalytic domain of alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792 59919003245 active site 59919003246 substrate binding site [chemical binding]; other site 59919003247 catalytic site [active] 59919003248 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 59919003249 2-isopropylmalate synthase; Validated; Region: PRK00915 59919003250 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 59919003251 active site 59919003252 catalytic residues [active] 59919003253 metal binding site [ion binding]; metal-binding site 59919003254 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 59919003255 4 probable transmembrane helices predicted by TMHMM2.0 59919003256 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 59919003257 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 59919003258 Zn2+ binding site [ion binding]; other site 59919003259 Mg2+ binding site [ion binding]; other site 59919003260 7 probable transmembrane helices predicted by TMHMM2.0 59919003261 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14186 59919003262 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 59919003263 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 59919003264 homodimer interface [polypeptide binding]; other site 59919003265 NADP binding site [chemical binding]; other site 59919003266 substrate binding site [chemical binding]; other site 59919003267 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 59919003268 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 59919003269 substrate binding pocket [chemical binding]; other site 59919003270 chain length determination region; other site 59919003271 substrate-Mg2+ binding site; other site 59919003272 catalytic residues [active] 59919003273 aspartate-rich region 1; other site 59919003274 active site lid residues [active] 59919003275 aspartate-rich region 2; other site 59919003276 Divergent PAP2 family; Region: DUF212; pfam02681 59919003277 3 probable transmembrane helices predicted by TMHMM2.0 59919003278 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 59919003279 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 59919003280 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 59919003281 catalytic triad [active] 59919003282 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 59919003283 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 59919003284 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 59919003285 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 59919003286 ferredoxin--NADP+ reductase; Provisional; Region: PLN03116 59919003287 These ferredoxin reductases are related to the NADPH cytochrome p450 reductases (CYPOR), but lack the FAD-binding region connecting sub-domain. Ferredoxin-NADP+ reductase (FNR) is an FAD-containing enzyme that catalyzes the reversible electron transfer...; Region: CYPOR_like_FNR; cd06208 59919003288 dimerization interface [polypeptide binding]; other site 59919003289 FAD binding pocket [chemical binding]; other site 59919003290 FAD binding motif [chemical binding]; other site 59919003291 catalytic residues [active] 59919003292 NAD binding pocket [chemical binding]; other site 59919003293 phosphate binding motif [ion binding]; other site 59919003294 beta-alpha-beta structure motif; other site 59919003295 1 probable transmembrane helix predicted by TMHMM2.0 59919003296 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 59919003297 hydrophobic ligand binding site; other site 59919003298 adaptive-response sensory kinase; Validated; Region: PRK09303 59919003299 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 59919003300 tetramer interface [polypeptide binding]; other site 59919003301 dimer interface [polypeptide binding]; other site 59919003302 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 59919003303 dimer interface [polypeptide binding]; other site 59919003304 phosphorylation site [posttranslational modification] 59919003305 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 59919003306 ATP binding site [chemical binding]; other site 59919003307 Mg2+ binding site [ion binding]; other site 59919003308 G-X-G motif; other site 59919003309 1 probable transmembrane helix predicted by TMHMM2.0 59919003310 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02812 59919003311 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 59919003312 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 59919003313 active site 59919003314 4-alpha-glucanotransferase; Provisional; Region: PRK14508 59919003315 1 probable transmembrane helix predicted by TMHMM2.0 59919003316 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 59919003317 ABC1 family; Region: ABC1; cl17513 59919003318 2 probable transmembrane helices predicted by TMHMM2.0 59919003319 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 59919003320 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 59919003321 catalytic residue [active] 59919003322 Regulator of G protein signaling (RGS) domain superfamily; Region: RGS; cl02565 59919003323 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 59919003324 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 59919003325 phosphatidate cytidylyltransferase; Region: PLN02953 59919003326 8 probable transmembrane helices predicted by TMHMM2.0 59919003327 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 59919003328 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 59919003329 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 59919003330 putative active site [active] 59919003331 metal binding site [ion binding]; metal-binding site 59919003332 Clp protease ATP binding subunit; Region: clpC; CHL00095 59919003333 Clp amino terminal domain; Region: Clp_N; pfam02861 59919003334 Clp amino terminal domain; Region: Clp_N; pfam02861 59919003335 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 59919003336 Walker A motif; other site 59919003337 ATP binding site [chemical binding]; other site 59919003338 Walker B motif; other site 59919003339 arginine finger; other site 59919003340 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 59919003341 Walker A motif; other site 59919003342 ATP binding site [chemical binding]; other site 59919003343 Walker B motif; other site 59919003344 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 59919003345 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 59919003346 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 59919003347 Coenzyme A binding pocket [chemical binding]; other site 59919003348 diaminopimelate decarboxylase; Region: lysA; TIGR01048 59919003349 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 59919003350 active site 59919003351 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 59919003352 substrate binding site [chemical binding]; other site 59919003353 catalytic residues [active] 59919003354 dimer interface [polypeptide binding]; other site 59919003355 TIGR00159 family protein; Region: TIGR00159 59919003356 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 59919003357 2 probable transmembrane helices predicted by TMHMM2.0 59919003358 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 59919003359 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 59919003360 catalytic residue [active] 59919003361 putative FPP diphosphate binding site; other site 59919003362 putative FPP binding hydrophobic cleft; other site 59919003363 dimer interface [polypeptide binding]; other site 59919003364 putative IPP diphosphate binding site; other site 59919003365 biotin synthase; Region: bioB; TIGR00433 59919003366 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 59919003367 FeS/SAM binding site; other site 59919003368 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 59919003369 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 59919003370 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 59919003371 active site residue [active] 59919003372 lipoyl synthase; Provisional; Region: PRK12928 59919003373 recombination protein RecR; Reviewed; Region: recR; PRK00076 59919003374 RecR protein; Region: RecR; pfam02132 59919003375 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 59919003376 putative active site [active] 59919003377 putative metal-binding site [ion binding]; other site 59919003378 tetramer interface [polypeptide binding]; other site 59919003379 PsbP; Region: PsbP; pfam01789 59919003380 1 probable transmembrane helix predicted by TMHMM2.0 59919003381 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 59919003382 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 59919003383 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 59919003384 Walker A/P-loop; other site 59919003385 ATP binding site [chemical binding]; other site 59919003386 Q-loop/lid; other site 59919003387 ABC transporter signature motif; other site 59919003388 Walker B; other site 59919003389 D-loop; other site 59919003390 H-loop/switch region; other site 59919003391 3 probable transmembrane helices predicted by TMHMM2.0 59919003392 helicase 45; Provisional; Region: PTZ00424 59919003393 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 59919003394 ATP binding site [chemical binding]; other site 59919003395 Mg++ binding site [ion binding]; other site 59919003396 motif III; other site 59919003397 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 59919003398 nucleotide binding region [chemical binding]; other site 59919003399 ATP-binding site [chemical binding]; other site 59919003400 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 59919003401 AAA domain; Region: AAA_30; pfam13604 59919003402 Family description; Region: UvrD_C_2; pfam13538 59919003403 UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361 59919003404 Phospholipid methyltransferase; Region: PEMT; cl17370 59919003405 3 probable transmembrane helices predicted by TMHMM2.0 59919003406 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 59919003407 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 59919003408 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 59919003409 Protein of unknown function (DUF2488); Region: Ycf54; pfam10674 59919003410 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 59919003411 active site 59919003412 hydrophilic channel; other site 59919003413 dimerization interface [polypeptide binding]; other site 59919003414 catalytic residues [active] 59919003415 active site lid [active] 59919003416 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 59919003417 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 59919003418 putative acyl-acceptor binding pocket; other site 59919003419 BolA-like protein; Region: BolA; pfam01722 59919003420 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 59919003421 putative GSH binding site [chemical binding]; other site 59919003422 catalytic residues [active] 59919003423 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 59919003424 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 59919003425 active site 59919003426 phosphorylation site [posttranslational modification] 59919003427 dimerization interface [polypeptide binding]; other site 59919003428 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 59919003429 DNA binding site [nucleotide binding] 59919003430 3 probable transmembrane helices predicted by TMHMM2.0 59919003431 carotene isomerase; Region: carot_isom; TIGR02730 59919003432 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 59919003433 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 59919003434 Glucose inhibited division protein A; Region: GIDA; pfam01134 59919003435 photosystem II protein Y; Reviewed; Region: pbsY; PRK13240 59919003436 putative high light inducible protein; Region: PHA02337 59919003437 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 59919003438 1 probable transmembrane helix predicted by TMHMM2.0 59919003439 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59919003440 binding surface 59919003441 TPR motif; other site 59919003442 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59919003443 TPR motif; other site 59919003444 binding surface 59919003445 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 59919003446 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 59919003447 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 59919003448 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 59919003449 active site 59919003450 HupE / UreJ protein; Region: HupE_UreJ; pfam04955 59919003451 7 probable transmembrane helices predicted by TMHMM2.0 59919003452 Autotransporter beta-domain; Region: Autotransporter; pfam03797 59919003453 1 probable transmembrane helix predicted by TMHMM2.0 59919003454 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 59919003455 10 probable transmembrane helices predicted by TMHMM2.0 59919003456 Chlorophyll A-B binding protein; Region: Chloroa_b-bind; cl02879 59919003457 1 probable transmembrane helix predicted by TMHMM2.0 59919003458 methionine S-methyltransferase; Region: PLN02672 59919003459 1 probable transmembrane helix predicted by TMHMM2.0 59919003460 1 probable transmembrane helix predicted by TMHMM2.0 59919003461 Uncharacterized conserved protein [Function unknown]; Region: COG0397 59919003462 hypothetical protein; Validated; Region: PRK00029 59919003463 Cupin domain; Region: Cupin_2; cl17218 59919003464 Protein of unknown function (DUF1651); Region: DUF1651; pfam07864 59919003465 putative high light inducible protein; Region: PHA02337 59919003466 1 probable transmembrane helix predicted by TMHMM2.0 59919003467 2 probable transmembrane helices predicted by TMHMM2.0 59919003468 1 probable transmembrane helix predicted by TMHMM2.0 59919003469 GTP-binding protein YchF; Reviewed; Region: PRK09601 59919003470 YchF GTPase; Region: YchF; cd01900 59919003471 G1 box; other site 59919003472 GTP/Mg2+ binding site [chemical binding]; other site 59919003473 Switch I region; other site 59919003474 G2 box; other site 59919003475 Switch II region; other site 59919003476 G3 box; other site 59919003477 G4 box; other site 59919003478 G5 box; other site 59919003479 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 59919003480 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 59919003481 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 59919003482 HlyD family secretion protein; Region: HlyD_3; pfam13437 59919003483 1 probable transmembrane helix predicted by TMHMM2.0 59919003484 DNA polymerase I; Provisional; Region: PRK05755 59919003485 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 59919003486 active site 59919003487 metal binding site 1 [ion binding]; metal-binding site 59919003488 putative 5' ssDNA interaction site; other site 59919003489 metal binding site 3; metal-binding site 59919003490 metal binding site 2 [ion binding]; metal-binding site 59919003491 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 59919003492 putative DNA binding site [nucleotide binding]; other site 59919003493 putative metal binding site [ion binding]; other site 59919003494 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 59919003495 active site 59919003496 catalytic site [active] 59919003497 substrate binding site [chemical binding]; other site 59919003498 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 59919003499 active site 59919003500 DNA binding site [nucleotide binding] 59919003501 catalytic site [active] 59919003502 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 59919003503 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 59919003504 active site 59919003505 HIGH motif; other site 59919003506 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 59919003507 KMSKS motif; other site 59919003508 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 59919003509 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 59919003510 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 59919003511 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 59919003512 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 59919003513 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 59919003514 dimer interface [polypeptide binding]; other site 59919003515 [2Fe-2S] cluster binding site [ion binding]; other site 59919003516 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 59919003517 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 59919003518 TAP-like protein; Region: Abhydrolase_4; pfam08386 59919003519 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 59919003520 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 59919003521 9 probable transmembrane helices predicted by TMHMM2.0 59919003522 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 59919003523 3 probable transmembrane helices predicted by TMHMM2.0 59919003524 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 59919003525 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 59919003526 ligand binding site [chemical binding]; other site 59919003527 homodimer interface [polypeptide binding]; other site 59919003528 NAD(P) binding site [chemical binding]; other site 59919003529 trimer interface B [polypeptide binding]; other site 59919003530 trimer interface A [polypeptide binding]; other site 59919003531 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 59919003532 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 59919003533 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 59919003534 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 59919003535 TRX domain, novel NADPH thioredoxin reductase (NTR) family; composed of fusion proteins found only in oxygenic photosynthetic organisms containing both TRX and NTR domains. The TRX domain functions as a protein disulfide reductase via the reversible...; Region: TRX_NTR; cd02949 59919003536 catalytic residues [active] 59919003537 1 probable transmembrane helix predicted by TMHMM2.0 59919003538 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 59919003539 rRNA binding site [nucleotide binding]; other site 59919003540 predicted 30S ribosome binding site; other site 59919003541 Ycf39; Provisional; Region: ycf39; CHL00194 59919003542 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 59919003543 NAD(P) binding site [chemical binding]; other site 59919003544 putative active site [active] 59919003545 cytochrome b6-f complex subunit PetM; Reviewed; Region: petM; PRK11876 59919003546 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 59919003547 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 59919003548 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 59919003549 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 59919003550 putative valine binding site [chemical binding]; other site 59919003551 dimer interface [polypeptide binding]; other site 59919003552 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 59919003553 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 59919003554 active site 59919003555 photosystem I assembly protein Ycf4; Provisional; Region: PRK02542 59919003556 2 probable transmembrane helices predicted by TMHMM2.0 59919003557 photosystem II protein D2; Region: psbD; CHL00004 59919003558 pheophytin binding site; other site 59919003559 chlorophyll binding site; other site 59919003560 quinone binding site; other site 59919003561 Fe binding site [ion binding]; other site 59919003562 6 probable transmembrane helices predicted by TMHMM2.0 59919003563 Photosystem II protein; Region: PSII; cl08223 59919003564 photosystem II 44 kDa subunit reaction center protein (also called P6 protein, CP43), bacterial and chloroplast; Region: psbC; TIGR01153 59919003565 5 probable transmembrane helices predicted by TMHMM2.0 59919003566 Maf-like protein; Region: Maf; pfam02545 59919003567 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 59919003568 active site 59919003569 dimer interface [polypeptide binding]; other site 59919003570 cobyric acid synthase; Provisional; Region: PRK00784 59919003571 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 59919003572 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 59919003573 catalytic triad [active] 59919003574 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 59919003575 catalytic loop [active] 59919003576 iron binding site [ion binding]; other site 59919003577 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 59919003578 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 59919003579 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 59919003580 dimer interface [polypeptide binding]; other site 59919003581 motif 1; other site 59919003582 active site 59919003583 motif 2; other site 59919003584 motif 3; other site 59919003585 Domain of unknown function (DUF1824); Region: DUF1824; pfam08854 59919003586 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 59919003587 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 59919003588 Protein of unknown function (DUF3386); Region: DUF3386; pfam11866 59919003589 flavodoxin FldA; Validated; Region: PRK09267 59919003590 AhpC/TSA antioxidant enzyme; Region: AhpC-TSA_2; pfam13911 59919003591 Uncharacterized conserved protein [Function unknown]; Region: COG4095 59919003592 3 probable transmembrane helices predicted by TMHMM2.0 59919003593 Membrane transport protein; Region: Mem_trans; cl09117 59919003594 7 probable transmembrane helices predicted by TMHMM2.0 59919003595 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 59919003596 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 59919003597 11 probable transmembrane helices predicted by TMHMM2.0 59919003598 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 59919003599 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 59919003600 putative ADP-binding pocket [chemical binding]; other site 59919003601 EamA-like transporter family; Region: EamA; pfam00892 59919003602 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 59919003603 EamA-like transporter family; Region: EamA; pfam00892 59919003604 8 probable transmembrane helices predicted by TMHMM2.0 59919003605 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 59919003606 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 59919003607 tandem repeat interface [polypeptide binding]; other site 59919003608 oligomer interface [polypeptide binding]; other site 59919003609 active site residues [active] 59919003610 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 59919003611 active site 59919003612 homotrimer interaction site [polypeptide binding]; other site 59919003613 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 59919003614 1 probable transmembrane helix predicted by TMHMM2.0 59919003615 Bacterial PH domain; Region: DUF304; pfam03703 59919003616 1 probable transmembrane helix predicted by TMHMM2.0 59919003617 putative inner membrane protein translocase component YidC; Provisional; Region: PRK02654 59919003618 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 59919003619 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 59919003620 3 probable transmembrane helices predicted by TMHMM2.0 59919003621 Ycf46; Provisional; Region: ycf46; CHL00195 59919003622 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 59919003623 Walker A motif; other site 59919003624 ATP binding site [chemical binding]; other site 59919003625 Walker B motif; other site 59919003626 arginine finger; other site 59919003627 seryl-tRNA synthetase; Provisional; Region: PRK05431 59919003628 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 59919003629 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 59919003630 dimer interface [polypeptide binding]; other site 59919003631 active site 59919003632 motif 1; other site 59919003633 motif 2; other site 59919003634 motif 3; other site 59919003635 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 59919003636 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 59919003637 active site 59919003638 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cd00136 59919003639 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 59919003640 putative substrate binding region [chemical binding]; other site 59919003641 4 probable transmembrane helices predicted by TMHMM2.0 59919003642 ribosomal protein S14; Region: rps14; CHL00074 59919003643 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 59919003644 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 59919003645 RNase E interface [polypeptide binding]; other site 59919003646 trimer interface [polypeptide binding]; other site 59919003647 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 59919003648 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 59919003649 RNase E interface [polypeptide binding]; other site 59919003650 trimer interface [polypeptide binding]; other site 59919003651 active site 59919003652 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 59919003653 putative nucleic acid binding region [nucleotide binding]; other site 59919003654 G-X-X-G motif; other site 59919003655 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 59919003656 RNA binding site [nucleotide binding]; other site 59919003657 domain interface; other site 59919003658 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 59919003659 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 59919003660 active site 59919003661 Predicted methyltransferases [General function prediction only]; Region: COG0313 59919003662 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 59919003663 putative SAM binding site [chemical binding]; other site 59919003664 putative homodimer interface [polypeptide binding]; other site 59919003665 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 59919003666 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 59919003667 Substrate binding site; other site 59919003668 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 59919003669 O-Antigen ligase; Region: Wzy_C; pfam04932 59919003670 4 probable transmembrane helices predicted by TMHMM2.0 59919003671 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 59919003672 12 probable transmembrane helices predicted by TMHMM2.0 59919003673 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 59919003674 GtrA-like protein; Region: GtrA; pfam04138 59919003675 6 probable transmembrane helices predicted by TMHMM2.0 59919003676 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 59919003677 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 59919003678 Ligand binding site; other site 59919003679 Putative Catalytic site; other site 59919003680 DXD motif; other site 59919003681 2 probable transmembrane helices predicted by TMHMM2.0 59919003682 CDP-tyvelose 2-epimerase, extended (e) SDRs; Region: CDP_TE_SDR_e; cd05258 59919003683 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 59919003684 NAD binding site [chemical binding]; other site 59919003685 homotetramer interface [polypeptide binding]; other site 59919003686 homodimer interface [polypeptide binding]; other site 59919003687 active site 59919003688 substrate binding site [chemical binding]; other site 59919003689 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 59919003690 extended (e) SDRs; Region: SDR_e; cd08946 59919003691 NAD(P) binding site [chemical binding]; other site 59919003692 active site 59919003693 substrate binding site [chemical binding]; other site 59919003694 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 59919003695 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 59919003696 NAD(P) binding site [chemical binding]; other site 59919003697 active site 59919003698 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 59919003699 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 59919003700 substrate binding site; other site 59919003701 lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407 59919003702 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 59919003703 inhibitor-cofactor binding pocket; inhibition site 59919003704 pyridoxal 5'-phosphate binding site [chemical binding]; other site 59919003705 catalytic residue [active] 59919003706 11 probable transmembrane helices predicted by TMHMM2.0 59919003707 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 59919003708 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 59919003709 NADP binding site [chemical binding]; other site 59919003710 active site 59919003711 putative substrate binding site [chemical binding]; other site 59919003712 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 59919003713 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 59919003714 NADP-binding site; other site 59919003715 homotetramer interface [polypeptide binding]; other site 59919003716 substrate binding site [chemical binding]; other site 59919003717 homodimer interface [polypeptide binding]; other site 59919003718 active site 59919003719 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 59919003720 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 59919003721 NAD binding site [chemical binding]; other site 59919003722 homodimer interface [polypeptide binding]; other site 59919003723 active site 59919003724 substrate binding site [chemical binding]; other site 59919003725 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 59919003726 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 59919003727 NAD(P) binding site [chemical binding]; other site 59919003728 active site 59919003729 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 59919003730 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 59919003731 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 59919003732 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 59919003733 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 59919003734 1 probable transmembrane helix predicted by TMHMM2.0 59919003735 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 59919003736 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 59919003737 active site 59919003738 motif I; other site 59919003739 motif II; other site 59919003740 hydroxyglutarate oxidase; Provisional; Region: PRK11728 59919003741 1 probable transmembrane helix predicted by TMHMM2.0 59919003742 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 59919003743 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 59919003744 active site 59919003745 Substrate binding site; other site 59919003746 Mg++ binding site; other site 59919003747 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 59919003748 dimer interface [polypeptide binding]; other site 59919003749 active site 59919003750 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 59919003751 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 59919003752 active site 59919003753 nucleotide binding site [chemical binding]; other site 59919003754 HIGH motif; other site 59919003755 KMSKS motif; other site 59919003756 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 59919003757 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 59919003758 putative ribose interaction site [chemical binding]; other site 59919003759 putative ADP binding site [chemical binding]; other site 59919003760 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 59919003761 extended (e) SDRs; Region: SDR_e; cd08946 59919003762 NAD(P) binding site [chemical binding]; other site 59919003763 active site 59919003764 substrate binding site [chemical binding]; other site 59919003765 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 59919003766 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 59919003767 active site 59919003768 1 probable transmembrane helix predicted by TMHMM2.0 59919003769 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 59919003770 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 59919003771 putative ADP-binding pocket [chemical binding]; other site 59919003772 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 59919003773 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 59919003774 active site 59919003775 Glycosyltransferase like family 2; Region: Glyco_tranf_2_2; pfam10111 59919003776 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 59919003777 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 59919003778 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 59919003779 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 59919003780 MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451 59919003781 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 59919003782 1 probable transmembrane helix predicted by TMHMM2.0 59919003783 7 probable transmembrane helices predicted by TMHMM2.0 59919003784 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 59919003785 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 59919003786 Mg++ binding site [ion binding]; other site 59919003787 putative catalytic motif [active] 59919003788 substrate binding site [chemical binding]; other site 59919003789 10 probable transmembrane helices predicted by TMHMM2.0 59919003790 1 probable transmembrane helix predicted by TMHMM2.0 59919003791 pyruvate dehydrogenase E1 component alpha subunit; Reviewed; Region: odpA; CHL00149 59919003792 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 59919003793 tetramer interface [polypeptide binding]; other site 59919003794 TPP-binding site [chemical binding]; other site 59919003795 heterodimer interface [polypeptide binding]; other site 59919003796 phosphorylation loop region [posttranslational modification] 59919003797 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 59919003798 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 59919003799 PYR/PP interface [polypeptide binding]; other site 59919003800 dimer interface [polypeptide binding]; other site 59919003801 TPP binding site [chemical binding]; other site 59919003802 cupin fold metalloprotein, WbuC family; Region: cupin_WbuC; TIGR04366 59919003803 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 59919003804 Methyltransferase domain; Region: Methyltransf_23; pfam13489 59919003805 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 59919003806 S-adenosylmethionine binding site [chemical binding]; other site 59919003807 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 59919003808 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 59919003809 NAD(P) binding site [chemical binding]; other site 59919003810 active site 59919003811 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 59919003812 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 59919003813 NAD binding site [chemical binding]; other site 59919003814 catalytic Zn binding site [ion binding]; other site 59919003815 substrate binding site [chemical binding]; other site 59919003816 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 59919003817 transketolase; Reviewed; Region: PRK05899 59919003818 TPP-binding site [chemical binding]; other site 59919003819 dimer interface [polypeptide binding]; other site 59919003820 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 59919003821 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 59919003822 PYR/PP interface [polypeptide binding]; other site 59919003823 dimer interface [polypeptide binding]; other site 59919003824 TPP binding site [chemical binding]; other site 59919003825 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 59919003826 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 59919003827 active site 59919003828 ATP binding site [chemical binding]; other site 59919003829 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 59919003830 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 59919003831 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 59919003832 Walker A/P-loop; other site 59919003833 ATP binding site [chemical binding]; other site 59919003834 Q-loop/lid; other site 59919003835 ABC transporter signature motif; other site 59919003836 Walker B; other site 59919003837 D-loop; other site 59919003838 H-loop/switch region; other site 59919003839 5 probable transmembrane helices predicted by TMHMM2.0 59919003840 Methyltransferase domain; Region: Methyltransf_31; pfam13847 59919003841 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 59919003842 S-adenosylmethionine binding site [chemical binding]; other site 59919003843 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 59919003844 S-adenosylmethionine binding site [chemical binding]; other site 59919003845 9 probable transmembrane helices predicted by TMHMM2.0 59919003846 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 59919003847 Methyltransferase domain; Region: Methyltransf_31; pfam13847 59919003848 S-adenosylmethionine binding site [chemical binding]; other site 59919003849 1 probable transmembrane helix predicted by TMHMM2.0 59919003850 3 probable transmembrane helices predicted by TMHMM2.0 59919003851 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 59919003852 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 59919003853 1 probable transmembrane helix predicted by TMHMM2.0 59919003854 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 59919003855 1 probable transmembrane helix predicted by TMHMM2.0 59919003856 3 probable transmembrane helices predicted by TMHMM2.0 59919003857 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 59919003858 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 59919003859 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 59919003860 active site 59919003861 trimer interface [polypeptide binding]; other site 59919003862 substrate binding site [chemical binding]; other site 59919003863 CoA binding site [chemical binding]; other site 59919003864 1 probable transmembrane helix predicted by TMHMM2.0 59919003865 Methyltransferase domain; Region: Methyltransf_23; pfam13489 59919003866 Methyltransferase domain; Region: Methyltransf_11; pfam08241 59919003867 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 59919003868 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 59919003869 Ligand binding site; other site 59919003870 Putative Catalytic site; other site 59919003871 DXD motif; other site 59919003872 2 probable transmembrane helices predicted by TMHMM2.0 59919003873 8 probable transmembrane helices predicted by TMHMM2.0 59919003874 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 59919003875 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 59919003876 active site 59919003877 1 probable transmembrane helix predicted by TMHMM2.0 59919003878 dTDP-glucose 4,6-dehydratase; Region: dTDP_gluc_dehyt; TIGR01181 59919003879 extended (e) SDRs; Region: SDR_e; cd08946 59919003880 NAD(P) binding site [chemical binding]; other site 59919003881 active site 59919003882 substrate binding site [chemical binding]; other site 59919003883 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 59919003884 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 59919003885 inhibitor-cofactor binding pocket; inhibition site 59919003886 pyridoxal 5'-phosphate binding site [chemical binding]; other site 59919003887 catalytic residue [active] 59919003888 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 59919003889 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 59919003890 inhibitor-cofactor binding pocket; inhibition site 59919003891 pyridoxal 5'-phosphate binding site [chemical binding]; other site 59919003892 catalytic residue [active] 59919003893 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 59919003894 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 59919003895 NAD binding site [chemical binding]; other site 59919003896 putative substrate binding site 2 [chemical binding]; other site 59919003897 putative substrate binding site 1 [chemical binding]; other site 59919003898 active site 59919003899 probable UDP-glucose 6-dehydrogenase; Region: PLN02353 59919003900 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 59919003901 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 59919003902 SOS regulatory protein LexA; Region: lexA; TIGR00498 59919003903 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 59919003904 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 59919003905 Catalytic site [active] 59919003906 ornithine carbamoyltransferase; Provisional; Region: PRK00779 59919003907 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 59919003908 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 59919003909 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 59919003910 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 59919003911 Walker A motif; other site 59919003912 ATP binding site [chemical binding]; other site 59919003913 Walker B motif; other site 59919003914 arginine finger; other site 59919003915 Peptidase family M41; Region: Peptidase_M41; pfam01434 59919003916 2 probable transmembrane helices predicted by TMHMM2.0 59919003917 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 59919003918 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 59919003919 catalytic motif [active] 59919003920 Zn binding site [ion binding]; other site 59919003921 RibD C-terminal domain; Region: RibD_C; cl17279 59919003922 Protein of unknown function (DUF3122); Region: DUF3122; pfam11320 59919003923 1 probable transmembrane helix predicted by TMHMM2.0 59919003924 1 probable transmembrane helix predicted by TMHMM2.0 59919003925 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 59919003926 active site 59919003927 SAM binding site [chemical binding]; other site 59919003928 putative homodimer interface [polypeptide binding]; other site 59919003929 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 59919003930 precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; Region: CbiT; TIGR02469 59919003931 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02649 59919003932 ATP-NAD kinase; Region: NAD_kinase; pfam01513 59919003933 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 59919003934 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 59919003935 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 59919003936 dimer interface [polypeptide binding]; other site 59919003937 motif 1; other site 59919003938 active site 59919003939 motif 2; other site 59919003940 motif 3; other site 59919003941 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 59919003942 Protein of unknown function (DUF3611); Region: DUF3611; pfam12263 59919003943 4 probable transmembrane helices predicted by TMHMM2.0 59919003944 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 59919003945 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 59919003946 active site 59919003947 Riboflavin kinase; Region: Flavokinase; smart00904 59919003948 thiamine-phosphate pyrophosphorylase; Provisional; Region: PRK02615 59919003949 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 59919003950 thiamine phosphate binding site [chemical binding]; other site 59919003951 active site 59919003952 pyrophosphate binding site [ion binding]; other site 59919003953 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 59919003954 thiS-thiF/thiG interaction site; other site 59919003955 AIR carboxylase; Region: AIRC; smart01001 59919003956 uncharacterized cyanobacterial protein, TIGR03792 family; Region: TIGR03792 59919003957 1 probable transmembrane helix predicted by TMHMM2.0 59919003958 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 59919003959 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 59919003960 homotrimer interaction site [polypeptide binding]; other site 59919003961 zinc binding site [ion binding]; other site 59919003962 CDP-binding sites; other site 59919003963 GTPase Era; Reviewed; Region: era; PRK00089 59919003964 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 59919003965 G1 box; other site 59919003966 GTP/Mg2+ binding site [chemical binding]; other site 59919003967 Switch I region; other site 59919003968 G2 box; other site 59919003969 Switch II region; other site 59919003970 G3 box; other site 59919003971 G4 box; other site 59919003972 G5 box; other site 59919003973 KH domain; Region: KH_2; pfam07650 59919003974 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 59919003975 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 59919003976 7 probable transmembrane helices predicted by TMHMM2.0 59919003977 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 59919003978 PhoH-like protein; Region: PhoH; pfam02562 59919003979 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 59919003980 signal recognition particle protein; Provisional; Region: PRK10867 59919003981 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 59919003982 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 59919003983 GTP binding site [chemical binding]; other site 59919003984 Signal peptide binding domain; Region: SRP_SPB; pfam02978 59919003985 Protein of unknown function (DUF4101); Region: DUF4101; pfam13355 59919003986 1 probable transmembrane helix predicted by TMHMM2.0 59919003987 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 59919003988 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 59919003989 tetramer interface [polypeptide binding]; other site 59919003990 TPP-binding site [chemical binding]; other site 59919003991 heterodimer interface [polypeptide binding]; other site 59919003992 phosphorylation loop region [posttranslational modification] 59919003993 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 59919003994 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 59919003995 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 59919003996 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 59919003997 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 59919003998 DNA binding residues [nucleotide binding] 59919003999 Uncharacterized conserved protein [Function unknown]; Region: COG0062 59919004000 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 59919004001 putative substrate binding site [chemical binding]; other site 59919004002 putative ATP binding site [chemical binding]; other site 59919004003 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 59919004004 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 59919004005 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 59919004006 putative active site [active] 59919004007 catalytic triad [active] 59919004008 putative dimer interface [polypeptide binding]; other site 59919004009 6 probable transmembrane helices predicted by TMHMM2.0 59919004010 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 59919004011 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 59919004012 superoxide dismutase, Ni; Region: sodN; TIGR02753 59919004013 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 59919004014 Catalytic site [active] 59919004015 6 probable transmembrane helices predicted by TMHMM2.0 59919004016 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 59919004017 active site 59919004018 ribulose/triose binding site [chemical binding]; other site 59919004019 phosphate binding site [ion binding]; other site 59919004020 substrate (anthranilate) binding pocket [chemical binding]; other site 59919004021 product (indole) binding pocket [chemical binding]; other site 59919004022 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 59919004023 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 59919004024 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 59919004025 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 59919004026 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 59919004027 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 59919004028 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 59919004029 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 59919004030 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 59919004031 hinge; other site 59919004032 active site 59919004033 acetylornithine aminotransferase; Provisional; Region: PRK02627 59919004034 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 59919004035 inhibitor-cofactor binding pocket; inhibition site 59919004036 pyridoxal 5'-phosphate binding site [chemical binding]; other site 59919004037 catalytic residue [active] 59919004038 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 59919004039 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 59919004040 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 59919004041 FAD binding domain; Region: FAD_binding_4; pfam01565 59919004042 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 59919004043 Amidohydrolase; Region: Amidohydro_4; pfam13147 59919004044 active site 59919004045 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14333 59919004046 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 59919004047 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 59919004048 FeS/SAM binding site; other site 59919004049 TRAM domain; Region: TRAM; pfam01938 59919004050 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 59919004051 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 59919004052 ATP-grasp domain; Region: ATP-grasp_4; cl17255 59919004053 1 probable transmembrane helix predicted by TMHMM2.0 59919004054 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 59919004055 1 probable transmembrane helix predicted by TMHMM2.0 59919004056 cell division protein FtsZ; Validated; Region: PRK09330 59919004057 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 59919004058 nucleotide binding site [chemical binding]; other site 59919004059 SulA interaction site; other site 59919004060 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 59919004061 oligomerization interface [polypeptide binding]; other site 59919004062 active site 59919004063 metal binding site [ion binding]; metal-binding site 59919004064 coproporphyrinogen III oxidase; Provisional; Region: PRK07379 59919004065 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 59919004066 FeS/SAM binding site; other site 59919004067 HemN C-terminal domain; Region: HemN_C; pfam06969 59919004068 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 59919004069 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 59919004070 putative active site [active] 59919004071 3 probable transmembrane helices predicted by TMHMM2.0 59919004072 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 59919004073 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 59919004074 oligomer interface [polypeptide binding]; other site 59919004075 active site residues [active] 59919004076 Clp protease; Region: CLP_protease; pfam00574 59919004077 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 59919004078 oligomer interface [polypeptide binding]; other site 59919004079 active site residues [active] 59919004080 ketol-acid reductoisomerase; Provisional; Region: PRK05479 59919004081 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 59919004082 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 59919004083 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 59919004084 4 probable transmembrane helices predicted by TMHMM2.0 59919004085 light-harvesting-like protein 3; Provisional; Region: PLN00014 59919004086 1 probable transmembrane helix predicted by TMHMM2.0 59919004087 1 probable transmembrane helix predicted by TMHMM2.0 59919004088 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 59919004089 IHF dimer interface [polypeptide binding]; other site 59919004090 IHF - DNA interface [nucleotide binding]; other site 59919004091 Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523 59919004092 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 59919004093 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 59919004094 active site 59919004095 catalytic site [active] 59919004096 MFS/sugar transport protein; Region: MFS_2; pfam13347 59919004097 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 59919004098 11 probable transmembrane helices predicted 1668 by TMHMM2.0 59919004099 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 59919004100 Permease; Region: Permease; pfam02405 59919004101 5 probable transmembrane helices predicted by TMHMM2.0 59919004102 Protein of unknown function (DUF3119); Region: DUF3119; pfam11317 59919004103 1 probable transmembrane helix predicted by TMHMM2.0 59919004104 Protein of unknown function (DUF3086); Region: DUF3086; pfam11285 59919004105 membrane protein; Provisional; Region: PRK14419 59919004106 5 probable transmembrane helices predicted by TMHMM2.0 59919004107 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 59919004108 active site 59919004109 dimer interface [polypeptide binding]; other site 59919004110 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 59919004111 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 59919004112 active site 59919004113 HIGH motif; other site 59919004114 dimer interface [polypeptide binding]; other site 59919004115 KMSKS motif; other site 59919004116 Domain of unknown function (DUF1825); Region: DUF1825; pfam08855 59919004117 multifunctional aminopeptidase A; Provisional; Region: PRK00913 59919004118 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 59919004119 interface (dimer of trimers) [polypeptide binding]; other site 59919004120 Substrate-binding/catalytic site; other site 59919004121 Zn-binding sites [ion binding]; other site 59919004122 Peptide methionine sulfoxide reductase; Region: PMSR; pfam01625 59919004123 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 59919004124 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 59919004125 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 59919004126 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 59919004127 active site 59919004128 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 59919004129 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 59919004130 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 59919004131 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 59919004132 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 59919004133 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 59919004134 Surface antigen; Region: Bac_surface_Ag; pfam01103 59919004135 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 59919004136 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 59919004137 ATP binding site [chemical binding]; other site 59919004138 active site 59919004139 substrate binding site [chemical binding]; other site 59919004140 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 59919004141 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 59919004142 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 59919004143 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 59919004144 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 59919004145 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 59919004146 dimerization interface [polypeptide binding]; other site 59919004147 PAS domain; Region: PAS; smart00091 59919004148 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 59919004149 dimer interface [polypeptide binding]; other site 59919004150 phosphorylation site [posttranslational modification] 59919004151 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 59919004152 ATP binding site [chemical binding]; other site 59919004153 Mg2+ binding site [ion binding]; other site 59919004154 G-X-G motif; other site 59919004155 2 probable transmembrane helices predicted by TMHMM2.0 59919004156 circadian clock protein KaiC; Region: circ_KaiC; TIGR02655 59919004157 KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124 59919004158 Walker A motif; other site 59919004159 ATP binding site [chemical binding]; other site 59919004160 Walker B motif; other site 59919004161 recA bacterial DNA recombination protein; Region: RecA; cl17211 59919004162 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 59919004163 Walker A motif; other site 59919004164 ATP binding site [chemical binding]; other site 59919004165 Walker B motif; other site 59919004166 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 59919004167 tetramer interface [polypeptide binding]; other site 59919004168 dimer interface [polypeptide binding]; other site 59919004169 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 59919004170 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 59919004171 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 59919004172 S-adenosylmethionine binding site [chemical binding]; other site 59919004173 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02755 59919004174 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 59919004175 RNA binding site [nucleotide binding]; other site 59919004176 active site 59919004177 Stage II sporulation protein; Region: SpoIID; pfam08486 59919004178 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 59919004179 ribonuclease Z; Region: RNase_Z; TIGR02651 59919004180 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 59919004181 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 59919004182 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 59919004183 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 59919004184 catalytic loop [active] 59919004185 iron binding site [ion binding]; other site 59919004186 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 59919004187 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 59919004188 S-adenosylmethionine binding site [chemical binding]; other site 59919004189 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 59919004190 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 59919004191 ligand binding site [chemical binding]; other site 59919004192 NAD binding site [chemical binding]; other site 59919004193 dimerization interface [polypeptide binding]; other site 59919004194 catalytic site [active] 59919004195 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 59919004196 putative L-serine binding site [chemical binding]; other site 59919004197 2 probable transmembrane helices predicted by TMHMM2.0 59919004198 photosystem II S4 domain protein; Region: PS_II_S4; TIGR03069 59919004199 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 59919004200 RNA binding surface [nucleotide binding]; other site 59919004201 4 probable transmembrane helices predicted by TMHMM2.0 59919004202 PPOX class probable FMN-dependent enzyme, alr4036 family; Region: PPOX_FMN_cyano; TIGR04026 59919004203 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxase_2; pfam12766 59919004204 Predicted membrane protein [Function unknown]; Region: COG2259 59919004205 2 probable transmembrane helices predicted by TMHMM2.0 59919004206 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 59919004207 short chain dehydrogenase; Provisional; Region: PRK06197 59919004208 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 59919004209 putative NAD(P) binding site [chemical binding]; other site 59919004210 active site 59919004211 Protein of unknown function; Region: DUF3721; pfam12518 59919004212 1 probable transmembrane helix predicted by TMHMM2.0 59919004213 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02705 59919004214 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 59919004215 Pirin-related protein [General function prediction only]; Region: COG1741 59919004216 Pirin; Region: Pirin; pfam02678 59919004217 Protein of unknown function (DUF1643); Region: DUF1643; pfam07799 59919004218 Predicted membrane protein (DUF2214); Region: DUF2214; pfam09980 59919004219 4 probable transmembrane helices predicted by TMHMM2.0 59919004220 GAF domain; Region: GAF; pfam01590 59919004221 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 59919004222 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 59919004223 flavoprotein, HI0933 family; Region: TIGR00275 59919004224 9 probable transmembrane helices predicted by TMHMM2.0 59919004225 Protein of unknown function (DUF861); Region: Cupin_3; pfam05899 59919004226 Protein of unknown function (DUF805); Region: DUF805; pfam05656 59919004227 2 probable transmembrane helices predicted by TMHMM2.0 59919004228 1 probable transmembrane helix predicted by TMHMM2.0 59919004229 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 59919004230 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 59919004231 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227 59919004232 NADP binding site [chemical binding]; other site 59919004233 putative substrate binding site [chemical binding]; other site 59919004234 active site 59919004235 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 59919004236 Fatty acid desaturase; Region: FA_desaturase; pfam00487 59919004237 putative di-iron ligands [ion binding]; other site 59919004238 4 probable transmembrane helices predicted by TMHMM2.0 59919004239 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 59919004240 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 59919004241 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 59919004242 active site 59919004243 motif I; other site 59919004244 motif II; other site 59919004245 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 59919004246 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 59919004247 Fatty acid desaturase; Region: FA_desaturase; pfam00487 59919004248 putative di-iron ligands [ion binding]; other site 59919004249 6 probable transmembrane helices predicted by TMHMM2.0 59919004250 Protein of unknown function (DUF938); Region: DUF938; pfam06080 59919004251 putative high light inducible protein; Region: PHA02337 59919004252 1 probable transmembrane helix predicted by TMHMM2.0 59919004253 putative high light inducible protein; Region: PHA02337 59919004254 1 probable transmembrane helix predicted by TMHMM2.0 59919004255 Predicted permeases [General function prediction only]; Region: COG0795 59919004256 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 59919004257 5 probable transmembrane helices predicted by TMHMM2.0 59919004258 Protein of unknown function (DUF2839); Region: DUF2839; pfam10999 59919004259 1 probable transmembrane helix predicted by TMHMM2.0 59919004260 Domain of Unknown Function (DUF1543); Region: DUF1543; pfam07566 59919004261 Domain of Unknown Function (DUF1543); Region: DUF1543; pfam07566 59919004262 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304 59919004263 putative high light inducible protein; Region: PHA02337 59919004264 1 probable transmembrane helix predicted by TMHMM2.0 59919004265 Protein of unknown function (DUF1651); Region: DUF1651; pfam07864 59919004266 3 probable transmembrane helices predicted by TMHMM2.0 59919004267 putative high light inducible protein; Region: PHA02337 59919004268 putative high light inducible protein; Region: PHA02337 59919004269 2 probable transmembrane helices predicted by TMHMM2.0 59919004270 putative high light inducible protein; Region: PHA02337 59919004271 1 probable transmembrane helix predicted by TMHMM2.0 59919004272 putative high light inducible protein; Region: PHA02337 59919004273 1 probable transmembrane helix predicted by TMHMM2.0 59919004274 Protein of unknown function (DUF3764); Region: DUF3764; pfam12594 59919004275 1 probable transmembrane helix predicted by TMHMM2.0 59919004276 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 59919004277 active site 59919004278 1 probable transmembrane helix predicted by TMHMM2.0 59919004279 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1934 59919004280 1 probable transmembrane helix predicted by TMHMM2.0 59919004281 Protein of unknown function (DUF3303); Region: DUF3303; pfam11746 59919004282 1 probable transmembrane helix predicted by TMHMM2.0 59919004283 Cupin domain; Region: Cupin_2; pfam07883 59919004284 1 probable transmembrane helix predicted by TMHMM2.0 59919004285 Protein of unknown function (DUF3303); Region: DUF3303; pfam11746 59919004286 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 59919004287 Catalytic site; other site 59919004288 Staphylococcal nuclease homologue; Region: SNase; pfam00565 59919004289 1 probable transmembrane helix predicted by TMHMM2.0 59919004290 1 probable transmembrane helix predicted by TMHMM2.0 59919004291 2 probable transmembrane helices predicted by TMHMM2.0 59919004292 Protein of unknown function; Region: DUF3721; pfam12518 59919004293 2 probable transmembrane helices predicted by TMHMM2.0 59919004294 Protein of unknown function, DUF; Region: DUF411; cl01142 59919004295 5 probable transmembrane helices predicted by TMHMM2.0 59919004296 1 probable transmembrane helix predicted by TMHMM2.0 59919004297 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 59919004298 EVE domain; Region: EVE; cl00728 59919004299 Protein of unknown function (DUF2811); Region: DUF2811; pfam10929 59919004300 Domain of unknown function (DUF1818); Region: DUF1818; pfam08848 59919004301 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 59919004302 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 59919004303 nucleotide binding site [chemical binding]; other site 59919004304 putative NEF/HSP70 interaction site [polypeptide binding]; other site 59919004305 SBD interface [polypeptide binding]; other site 59919004306 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 59919004307 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 59919004308 active site 59919004309 phosphoglyceromutase; Provisional; Region: PRK05434 59919004310 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307 59919004311 2 probable transmembrane helices predicted by TMHMM2.0 59919004312 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 59919004313 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 59919004314 ring oligomerisation interface [polypeptide binding]; other site 59919004315 ATP/Mg binding site [chemical binding]; other site 59919004316 stacking interactions; other site 59919004317 hinge regions; other site 59919004318 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 59919004319 oligomerisation interface [polypeptide binding]; other site 59919004320 mobile loop; other site 59919004321 roof hairpin; other site 59919004322 ATP synthase CF1 beta subunit; Region: atpB; CHL00060 59919004323 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 59919004324 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 59919004325 alpha subunit interaction interface [polypeptide binding]; other site 59919004326 Walker A motif; other site 59919004327 ATP binding site [chemical binding]; other site 59919004328 Walker B motif; other site 59919004329 inhibitor binding site; inhibition site 59919004330 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 59919004331 ATP synthase CF1 epsilon subunit; Region: atpE; CHL00063 59919004332 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 59919004333 gamma subunit interface [polypeptide binding]; other site 59919004334 epsilon subunit interface [polypeptide binding]; other site 59919004335 LBP interface [polypeptide binding]; other site 59919004336 hypothetical protein; Provisional; Region: PRK02724 59919004337 proline aminopeptidase P II; Provisional; Region: PRK10879 59919004338 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 59919004339 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 59919004340 active site 59919004341 Domain of unknown function DUF21; Region: DUF21; pfam01595 59919004342 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 59919004343 3 probable transmembrane helices predicted by TMHMM2.0 59919004344 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 59919004345 G1 box; other site 59919004346 GTP/Mg2+ binding site [chemical binding]; other site 59919004347 Switch I region; other site 59919004348 G2 box; other site 59919004349 Switch II region; other site 59919004350 G3 box; other site 59919004351 G4 box; other site 59919004352 Domain of unknown function (DUF697); Region: DUF697; pfam05128 59919004353 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 59919004354 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 59919004355 active site 59919004356 (T/H)XGH motif; other site 59919004357 NAD synthetase; Provisional; Region: PRK13981 59919004358 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 59919004359 multimer interface [polypeptide binding]; other site 59919004360 active site 59919004361 catalytic triad [active] 59919004362 protein interface 1 [polypeptide binding]; other site 59919004363 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 59919004364 homodimer interface [polypeptide binding]; other site 59919004365 NAD binding pocket [chemical binding]; other site 59919004366 ATP binding pocket [chemical binding]; other site 59919004367 Mg binding site [ion binding]; other site 59919004368 active-site loop [active] 59919004369 Protein of unknown function (DUF3326); Region: DUF3326; pfam11805 59919004370 Pleckstrin homology-like domain; Region: PH-like; cl17171 59919004371 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 59919004372 catalytic loop [active] 59919004373 iron binding site [ion binding]; other site 59919004374 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 59919004375 core domain interface [polypeptide binding]; other site 59919004376 delta subunit interface [polypeptide binding]; other site 59919004377 epsilon subunit interface [polypeptide binding]; other site 59919004378 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 59919004379 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 59919004380 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 59919004381 beta subunit interaction interface [polypeptide binding]; other site 59919004382 Walker A motif; other site 59919004383 ATP binding site [chemical binding]; other site 59919004384 Walker B motif; other site 59919004385 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 59919004386 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13429 59919004387 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 59919004388 F0F1 ATP synthase subunit B; Validated; Region: PRK07352 59919004389 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 59919004390 1 probable transmembrane helix predicted by TMHMM2.0 59919004391 F0F1 ATP synthase subunit B'; Validated; Region: PRK07353 59919004392 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 59919004393 1 probable transmembrane helix predicted by TMHMM2.0 59919004394 ATP synthase CF0 C subunit; Region: atpH; CHL00061 59919004395 2 probable transmembrane helices predicted by TMHMM2.0 59919004396 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 59919004397 ATP synthase CF0 A subunit; Region: atpI; CHL00046 59919004398 5 probable transmembrane helices predicted by TMHMM2.0 59919004399 3 probable transmembrane helices predicted by TMHMM2.0 59919004400 Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098 59919004401 9 probable transmembrane helices predicted by TMHMM2.0 59919004402 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 59919004403 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 59919004404 6 probable transmembrane helices predicted by TMHMM2.0 59919004405 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 59919004406 ResB-like family; Region: ResB; pfam05140 59919004407 4 probable transmembrane helices predicted by TMHMM2.0 59919004408 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 59919004409 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 59919004410 Nitrogen regulatory protein P-II; Region: P-II; smart00938 59919004411 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 59919004412 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 59919004413 RNA binding surface [nucleotide binding]; other site 59919004414 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 59919004415 adenylosuccinate lyase; Provisional; Region: PRK07380 59919004416 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 59919004417 tetramer interface [polypeptide binding]; other site 59919004418 active site 59919004419 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 59919004420 fumarate hydratase; Reviewed; Region: fumC; PRK00485 59919004421 Class II fumarases; Region: Fumarase_classII; cd01362 59919004422 active site 59919004423 tetramer interface [polypeptide binding]; other site 59919004424 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 59919004425 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 59919004426 ATP binding site [chemical binding]; other site 59919004427 putative Mg++ binding site [ion binding]; other site 59919004428 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 59919004429 nucleotide binding region [chemical binding]; other site 59919004430 ATP-binding site [chemical binding]; other site 59919004431 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 59919004432 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 59919004433 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 59919004434 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 59919004435 catalytic residue [active] 59919004436 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 59919004437 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 59919004438 S-adenosylmethionine binding site [chemical binding]; other site 59919004439 AAA domain; Region: AAA_26; pfam13500 59919004440 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 59919004441 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 59919004442 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 59919004443 inhibitor-cofactor binding pocket; inhibition site 59919004444 pyridoxal 5'-phosphate binding site [chemical binding]; other site 59919004445 catalytic residue [active] 59919004446 Protein of unknown function (DUF3143); Region: DUF3143; pfam11341 59919004447 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 59919004448 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 59919004449 HSP70 interaction site [polypeptide binding]; other site 59919004450 1 probable transmembrane helix predicted by TMHMM2.0 59919004451 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 59919004452 Methyltransferase domain; Region: Methyltransf_31; pfam13847 59919004453 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 59919004454 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 59919004455 active site 59919004456 catalytic tetrad [active] 59919004457 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 59919004458 Protein of unknown function (DUF1257); Region: DUF1257; pfam06868 59919004459 Protein of unknown function (DUF2997); Region: DUF2997; pfam11211 59919004460 HEAT repeats; Region: HEAT_2; pfam13646 59919004461 HEAT repeats; Region: HEAT_2; pfam13646 59919004462 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14457 59919004463 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 59919004464 FeS/SAM binding site; other site 59919004465 1 probable transmembrane helix predicted by TMHMM2.0 59919004466 DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597 59919004467 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 59919004468 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 59919004469 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 59919004470 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 59919004471 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 59919004472 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 59919004473 DNA binding site [nucleotide binding] 59919004474 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 59919004475 DNA-directed RNA polymerase subunit gamma; Provisional; Region: rpoC1; PRK02625 59919004476 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 59919004477 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 59919004478 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 59919004479 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 59919004480 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 59919004481 RPB1 interaction site [polypeptide binding]; other site 59919004482 RPB10 interaction site [polypeptide binding]; other site 59919004483 RPB11 interaction site [polypeptide binding]; other site 59919004484 RPB3 interaction site [polypeptide binding]; other site 59919004485 RPB12 interaction site [polypeptide binding]; other site 59919004486 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 59919004487 active site 59919004488 ribosomal protein S20; Region: rps20; CHL00102 59919004489 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 59919004490 histidinol dehydrogenase; Region: hisD; TIGR00069 59919004491 NAD binding site [chemical binding]; other site 59919004492 dimerization interface [polypeptide binding]; other site 59919004493 product binding site; other site 59919004494 substrate binding site [chemical binding]; other site 59919004495 zinc binding site [ion binding]; other site 59919004496 catalytic residues [active] 59919004497 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 59919004498 tetramer (dimer of dimers) interface [polypeptide binding]; other site 59919004499 active site 59919004500 dimer interface [polypeptide binding]; other site 59919004501 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 59919004502 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 59919004503 protein binding site [polypeptide binding]; other site 59919004504 1 probable transmembrane helix predicted by TMHMM2.0 59919004505 hypothetical protein; Provisional; Region: PRK14646 59919004506 ribosome maturation protein RimP; Reviewed; Region: PRK00092 59919004507 heptamer interface [polypeptide binding]; other site 59919004508 Sm1 motif; other site 59919004509 hexamer interface [polypeptide binding]; other site 59919004510 RNA binding site [nucleotide binding]; other site 59919004511 Sm2 motif; other site 59919004512 NusA N-terminal domain; Region: NusA_N; pfam08529 59919004513 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 59919004514 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 59919004515 RNA binding site [nucleotide binding]; other site 59919004516 homodimer interface [polypeptide binding]; other site 59919004517 NusA-like KH domain; Region: KH_5; pfam13184 59919004518 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 59919004519 G-X-X-G motif; other site 59919004520 Protein of unknown function (DUF448); Region: DUF448; pfam04296 59919004521 putative RNA binding cleft [nucleotide binding]; other site 59919004522 translation initiation factor IF-2; Region: IF-2; TIGR00487 59919004523 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 59919004524 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 59919004525 G1 box; other site 59919004526 putative GEF interaction site [polypeptide binding]; other site 59919004527 GTP/Mg2+ binding site [chemical binding]; other site 59919004528 Switch I region; other site 59919004529 G2 box; other site 59919004530 G3 box; other site 59919004531 Switch II region; other site 59919004532 G4 box; other site 59919004533 G5 box; other site 59919004534 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 59919004535 Translation-initiation factor 2; Region: IF-2; pfam11987 59919004536 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 59919004537 Protein of unknown function (DUF3493); Region: DUF3493; pfam11998 59919004538 2 probable transmembrane helices predicted by TMHMM2.0 59919004539 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 59919004540 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 59919004541 11 probable transmembrane helices predicted 1789 by TMHMM2.0 59919004542 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 59919004543 Ligand binding site; other site 59919004544 Putative Catalytic site; other site 59919004545 DXD motif; other site 59919004546 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 59919004547 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 59919004548 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 59919004549 FeS/SAM binding site; other site 59919004550 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 59919004551 L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590 59919004552 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 59919004553 pyridoxal 5'-phosphate binding site [chemical binding]; other site 59919004554 homodimer interface [polypeptide binding]; other site 59919004555 catalytic residue [active] 59919004556 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 59919004557 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 59919004558 homodimer interface [polypeptide binding]; other site 59919004559 oligonucleotide binding site [chemical binding]; other site 59919004560 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 59919004561 RNA/DNA hybrid binding site [nucleotide binding]; other site 59919004562 active site 59919004563 Protein of unknown function (DUF1997); Region: DUF1997; pfam09366 59919004564 prephenate dehydratase; Provisional; Region: PRK11898 59919004565 Prephenate dehydratase; Region: PDT; pfam00800 59919004566 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 59919004567 putative L-Phe binding site [chemical binding]; other site 59919004568 Methyltransferase domain; Region: Methyltransf_31; pfam13847 59919004569 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 59919004570 S-adenosylmethionine binding site [chemical binding]; other site 59919004571 1 probable transmembrane helix predicted by TMHMM2.0 59919004572 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 59919004573 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 59919004574 elongation factor Tu; Reviewed; Region: PRK00049 59919004575 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 59919004576 G1 box; other site 59919004577 GEF interaction site [polypeptide binding]; other site 59919004578 GTP/Mg2+ binding site [chemical binding]; other site 59919004579 Switch I region; other site 59919004580 G2 box; other site 59919004581 G3 box; other site 59919004582 Switch II region; other site 59919004583 G4 box; other site 59919004584 G5 box; other site 59919004585 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 59919004586 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 59919004587 Antibiotic Binding Site [chemical binding]; other site 59919004588 elongation factor G; Reviewed; Region: PRK00007 59919004589 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 59919004590 G1 box; other site 59919004591 putative GEF interaction site [polypeptide binding]; other site 59919004592 GTP/Mg2+ binding site [chemical binding]; other site 59919004593 Switch I region; other site 59919004594 G2 box; other site 59919004595 G3 box; other site 59919004596 Switch II region; other site 59919004597 G4 box; other site 59919004598 G5 box; other site 59919004599 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 59919004600 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 59919004601 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 59919004602 30S ribosomal protein S7; Validated; Region: PRK05302 59919004603 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 59919004604 S17 interaction site [polypeptide binding]; other site 59919004605 S8 interaction site; other site 59919004606 16S rRNA interaction site [nucleotide binding]; other site 59919004607 streptomycin interaction site [chemical binding]; other site 59919004608 23S rRNA interaction site [nucleotide binding]; other site 59919004609 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 59919004610 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 59919004611 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 59919004612 active site 59919004613 dimer interface [polypeptide binding]; other site 59919004614 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 59919004615 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 59919004616 active site 59919004617 FMN binding site [chemical binding]; other site 59919004618 substrate binding site [chemical binding]; other site 59919004619 3Fe-4S cluster binding site [ion binding]; other site 59919004620 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239 59919004621 domain_subunit interface; other site 59919004622 YCII-related domain; Region: YCII; cl00999 59919004623 lipoyl synthase; Provisional; Region: PRK05481 59919004624 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 59919004625 FeS/SAM binding site; other site 59919004626 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 59919004627 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 59919004628 catalytic residues [active] 59919004629 catalytic nucleophile [active] 59919004630 Presynaptic Site I dimer interface [polypeptide binding]; other site 59919004631 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 59919004632 Synaptic Flat tetramer interface [polypeptide binding]; other site 59919004633 Synaptic Site I dimer interface [polypeptide binding]; other site 59919004634 DNA binding site [nucleotide binding] 59919004635 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 59919004636 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 59919004637 NlpC/P60 family; Region: NLPC_P60; pfam00877 59919004638 photosystem I reaction center protein subunit XI; Provisional; Region: PRK00704 59919004639 2 probable transmembrane helices predicted by TMHMM2.0 59919004640 photosystem I reaction center subunit VIII; Reviewed; Region: psaI; PRK11877 59919004641 1 probable transmembrane helix predicted by TMHMM2.0 59919004642 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 59919004643 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 59919004644 Ligand binding site; other site 59919004645 Putative Catalytic site; other site 59919004646 DXD motif; other site 59919004647 2 probable transmembrane helices predicted by TMHMM2.0 59919004648 photosystem I P700 chlorophyll a apoprotein A2; Provisional; Region: psaB; PRK13199 59919004649 12 probable transmembrane helices predicted by TMHMM2.0 59919004650 photosystem I P700 chlorophyll a apoprotein A1; Provisional; Region: psaA; PRK13200 59919004651 11 probable transmembrane helices predicted by TMHMM2.0 59919004652 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 59919004653 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 59919004654 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 59919004655 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 59919004656 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 59919004657 active site 59919004658 SAM binding site [chemical binding]; other site 59919004659 homodimer interface [polypeptide binding]; other site 59919004660 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 59919004661 haloacid dehalogenase superfamily, subfamily IA hydrolase, TIGR01548; Region: HAD-SF-IA-hyp1 59919004662 alanine racemase; Reviewed; Region: alr; PRK00053 59919004663 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 59919004664 active site 59919004665 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 59919004666 dimer interface [polypeptide binding]; other site 59919004667 substrate binding site [chemical binding]; other site 59919004668 catalytic residues [active] 59919004669 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 59919004670 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 59919004671 active site 59919004672 peptide chain release factor 1; Validated; Region: prfA; PRK00591 59919004673 This domain is found in peptide chain release factors; Region: PCRF; smart00937 59919004674 RF-1 domain; Region: RF-1; pfam00472 59919004675 ribosomal protein L31; Validated; Region: rpl31; CHL00136 59919004676 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 59919004677 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 59919004678 23S rRNA interface [nucleotide binding]; other site 59919004679 L3 interface [polypeptide binding]; other site 59919004680 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 59919004681 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 59919004682 dimerization interface 3.5A [polypeptide binding]; other site 59919004683 active site 59919004684 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 59919004685 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 59919004686 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 59919004687 alphaNTD homodimer interface [polypeptide binding]; other site 59919004688 alphaNTD - beta interaction site [polypeptide binding]; other site 59919004689 alphaNTD - beta' interaction site [polypeptide binding]; other site 59919004690 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 59919004691 30S ribosomal protein S11; Validated; Region: PRK05309 59919004692 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 59919004693 30S ribosomal protein S13; Region: bact_S13; TIGR03631 59919004694 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 59919004695 adenylate kinase; Provisional; Region: PRK14531 59919004696 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 59919004697 AMP-binding site [chemical binding]; other site 59919004698 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 59919004699 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 59919004700 SecY translocase; Region: SecY; pfam00344 59919004701 10 probable transmembrane helices predicted by TMHMM2.0 59919004702 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 59919004703 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 59919004704 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 59919004705 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 59919004706 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 59919004707 5S rRNA interface [nucleotide binding]; other site 59919004708 L27 interface [polypeptide binding]; other site 59919004709 23S rRNA interface [nucleotide binding]; other site 59919004710 L5 interface [polypeptide binding]; other site 59919004711 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 59919004712 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 59919004713 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 59919004714 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 59919004715 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 59919004716 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 59919004717 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 59919004718 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 59919004719 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 59919004720 RNA binding site [nucleotide binding]; other site 59919004721 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 59919004722 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 59919004723 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 59919004724 23S rRNA interface [nucleotide binding]; other site 59919004725 putative translocon interaction site; other site 59919004726 signal recognition particle (SRP54) interaction site; other site 59919004727 L23 interface [polypeptide binding]; other site 59919004728 trigger factor interaction site; other site 59919004729 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 59919004730 23S rRNA interface [nucleotide binding]; other site 59919004731 5S rRNA interface [nucleotide binding]; other site 59919004732 putative antibiotic binding site [chemical binding]; other site 59919004733 L25 interface [polypeptide binding]; other site 59919004734 L27 interface [polypeptide binding]; other site 59919004735 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 59919004736 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 59919004737 G-X-X-G motif; other site 59919004738 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 59919004739 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 59919004740 putative translocon binding site; other site 59919004741 protein-rRNA interface [nucleotide binding]; other site 59919004742 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 59919004743 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 59919004744 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 59919004745 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 59919004746 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 59919004747 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 59919004748 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 59919004749 NADH-quinone oxidoreductase cyanobacterial subunit N; Region: NdhN; pfam11909 59919004750 Protein of unknown function (DUF561); Region: DUF561; pfam04481 59919004751 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 59919004752 Iron-Sulfur binding protein C terminal; Region: LdpA_C; pfam12617 59919004753 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 59919004754 recombinase A; Provisional; Region: recA; PRK09354 59919004755 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 59919004756 hexamer interface [polypeptide binding]; other site 59919004757 Walker A motif; other site 59919004758 ATP binding site [chemical binding]; other site 59919004759 Walker B motif; other site 59919004760 Protein of unknown function (DUF2839); Region: DUF2839; pfam10999 59919004761 1 probable transmembrane helix predicted by TMHMM2.0 59919004762 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 59919004763 arogenate dehydrogenase; Reviewed; Region: PRK07417 59919004764 prephenate dehydrogenase; Validated; Region: PRK08507 59919004765 C-3',4' desaturase CrtD; Region: desat_CrtD; TIGR02733 59919004766 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 59919004767 1 probable transmembrane helix predicted by TMHMM2.0 59919004768 Fructosamine kinase; Region: Fructosamin_kin; cl17579 59919004769 Domain of unknown function (DUF4308); Region: DUF4308; pfam14159 59919004770 2 probable transmembrane helices predicted by TMHMM2.0 59919004771 hypothetical protein; Validated; Region: PRK07411 59919004772 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 59919004773 ATP binding site [chemical binding]; other site 59919004774 substrate interface [chemical binding]; other site 59919004775 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 59919004776 active site residue [active] 59919004777 1 probable transmembrane helix predicted by TMHMM2.0 59919004778 hypothetical protein; Validated; Region: PRK07413 59919004779 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; pfam02572 59919004780 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 59919004781 Walker A motif; other site 59919004782 homodimer interface [polypeptide binding]; other site 59919004783 ATP binding site [chemical binding]; other site 59919004784 hydroxycobalamin binding site [chemical binding]; other site 59919004785 Walker B motif; other site 59919004786 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 59919004787 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 59919004788 Ligand Binding Site [chemical binding]; other site 59919004789 S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK02770 59919004790 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 59919004791 Q-loop/lid; other site 59919004792 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 59919004793 ABC transporter signature motif; other site 59919004794 Walker B; other site 59919004795 D-loop; other site 59919004796 H-loop/switch region; other site 59919004797 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 59919004798 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 59919004799 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 59919004800 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 59919004801 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 59919004802 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 59919004803 PsaD; Region: PsaD; pfam02531 59919004804 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 59919004805 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 59919004806 dimer interface [polypeptide binding]; other site 59919004807 phosphorylation site [posttranslational modification] 59919004808 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 59919004809 10 probable transmembrane helices predicted by TMHMM2.0 59919004810 Domain of unknown function DUF59; Region: DUF59; pfam01883 59919004811 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 59919004812 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 59919004813 Walker A motif; other site 59919004814 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 59919004815 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 59919004816 Protein of unknown function (DUF3529); Region: DUF3529; pfam12046 59919004817 3 probable transmembrane helices predicted by TMHMM2.0 59919004818 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 59919004819 catalytic site [active] 59919004820 putative active site [active] 59919004821 putative substrate binding site [chemical binding]; other site 59919004822 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370 59919004823 conserved hypothetical protein; Region: TIGR03492 59919004824 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 59919004825 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 59919004826 dimerization interface [polypeptide binding]; other site 59919004827 putative ATP binding site [chemical binding]; other site 59919004828 bifunctional pantoate ligase/cytidylate kinase; Provisional; Region: PRK13477 59919004829 Pantoate-beta-alanine ligase; Region: PanC; cd00560 59919004830 active site 59919004831 ATP-binding site [chemical binding]; other site 59919004832 pantoate-binding site; other site 59919004833 HXXH motif; other site 59919004834 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 59919004835 CMP-binding site; other site 59919004836 The sites determining sugar specificity; other site 59919004837 Low molecular weight phosphatase family; Region: LMWPc; cd00115 59919004838 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 59919004839 active site 59919004840 phycoerythrobilin:ferredoxin oxidoreductase; Provisional; Region: PRK13248 59919004841 dihydrobiliverdin:ferredoxin oxidoreductase; Provisional; Region: PRK13246 59919004842 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 59919004843 heme binding pocket [chemical binding]; other site 59919004844 heme ligand [chemical binding]; other site 59919004845 isocitrate dehydrogenase; Validated; Region: PRK07362 59919004846 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 59919004847 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 59919004848 Aldose 1-epimerase, similar to Synechocystis Slr1438; Region: Aldose_epim_Slr1438; cd09025 59919004849 active site 59919004850 catalytic residues [active] 59919004851 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 59919004852 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 59919004853 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 59919004854 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 59919004855 11 probable transmembrane helices predicted by TMHMM2.0 59919004856 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 59919004857 homodimer interface [polypeptide binding]; other site 59919004858 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 59919004859 active site pocket [active] 59919004860 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 59919004861 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 59919004862 dimerization interface [polypeptide binding]; other site 59919004863 active site 59919004864 metal binding site [ion binding]; metal-binding site 59919004865 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 59919004866 dsRNA binding site [nucleotide binding]; other site 59919004867 Protein of unknown function (DUF3252); Region: DUF3252; pfam11623 59919004868 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 59919004869 RimM N-terminal domain; Region: RimM; pfam01782 59919004870 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 59919004871 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 59919004872 glutaminase active site [active] 59919004873 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 59919004874 dimer interface [polypeptide binding]; other site 59919004875 active site 59919004876 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 59919004877 dimer interface [polypeptide binding]; other site 59919004878 active site 59919004879 photosystem I subunit VII; Region: psaC; CHL00065 59919004880 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 59919004881 acyl carrier protein; Provisional; Region: acpP; PRK00982 59919004882 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 59919004883 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 59919004884 dimer interface [polypeptide binding]; other site 59919004885 active site 59919004886 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 59919004887 transketolase; Region: PLN02790 59919004888 TPP-binding site [chemical binding]; other site 59919004889 dimer interface [polypeptide binding]; other site 59919004890 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 59919004891 PYR/PP interface [polypeptide binding]; other site 59919004892 dimer interface [polypeptide binding]; other site 59919004893 TPP binding site [chemical binding]; other site 59919004894 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 59919004895 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 59919004896 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 59919004897 Protein of unknown function (DUF3188); Region: DUF3188; pfam11384 59919004898 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 59919004899 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 59919004900 metal binding site [ion binding]; metal-binding site 59919004901 dimer interface [polypeptide binding]; other site 59919004902 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59919004903 binding surface 59919004904 TPR motif; other site 59919004905 TPR repeat; Region: TPR_11; pfam13414 59919004906 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59919004907 binding surface 59919004908 TPR motif; other site 59919004909 1 probable transmembrane helix predicted by TMHMM2.0 59919004910 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 59919004911 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 59919004912 Walker A motif; other site 59919004913 ATP binding site [chemical binding]; other site 59919004914 Walker B motif; other site 59919004915 arginine finger; other site 59919004916 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 59919004917 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 59919004918 SmpB-tmRNA interface; other site 59919004919 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 59919004920 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 59919004921 dimer interface [polypeptide binding]; other site 59919004922 putative anticodon binding site; other site 59919004923 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 59919004924 motif 1; other site 59919004925 active site 59919004926 motif 2; other site 59919004927 motif 3; other site 59919004928 Ycf27; Reviewed; Region: orf27; CHL00148 59919004929 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 59919004930 active site 59919004931 phosphorylation site [posttranslational modification] 59919004932 intermolecular recognition site; other site 59919004933 dimerization interface [polypeptide binding]; other site 59919004934 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 59919004935 DNA binding site [nucleotide binding] 59919004936 4 probable transmembrane helices predicted by TMHMM2.0 59919004937 rod shape-determining protein MreC; Provisional; Region: PRK13922 59919004938 rod shape-determining protein MreC; Region: MreC; pfam04085 59919004939 1 probable transmembrane helix predicted by TMHMM2.0 59919004940 rod shape-determining protein MreB; Provisional; Region: PRK13927 59919004941 MreB and similar proteins; Region: MreB_like; cd10225 59919004942 nucleotide binding site [chemical binding]; other site 59919004943 Mg binding site [ion binding]; other site 59919004944 putative protofilament interaction site [polypeptide binding]; other site 59919004945 RodZ interaction site [polypeptide binding]; other site 59919004946 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 59919004947 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 59919004948 dimer interface [polypeptide binding]; other site 59919004949 ssDNA binding site [nucleotide binding]; other site 59919004950 tetramer (dimer of dimers) interface [polypeptide binding]; other site 59919004951 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 59919004952 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 59919004953 4 probable transmembrane helices predicted by TMHMM2.0 59919004954 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 59919004955 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 59919004956 homotetramer interface [polypeptide binding]; other site 59919004957 ligand binding site [chemical binding]; other site 59919004958 catalytic site [active] 59919004959 NAD binding site [chemical binding]; other site 59919004960 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 59919004961 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 59919004962 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 59919004963 putative substrate binding site [chemical binding]; other site 59919004964 putative ATP binding site [chemical binding]; other site 59919004965 hydrolase, alpha/beta fold family protein; Region: PLN02824 59919004966 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 59919004967 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 59919004968 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 59919004969 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 59919004970 Sigma-70, region 4; Region: Sigma70_r4; pfam04545 59919004971 DNA binding residues [nucleotide binding] 59919004972 Mg2+ transporter (mgtE); Region: mgtE; TIGR00400 59919004973 MgtE intracellular N domain; Region: MgtE_N; smart00924 59919004974 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 59919004975 Divalent cation transporter; Region: MgtE; pfam01769 59919004976 5 probable transmembrane helices predicted by TMHMM2.0 59919004977 4 probable transmembrane helices predicted by TMHMM2.0 59919004978 CrcB-like protein; Region: CRCB; pfam02537 59919004979 4 probable transmembrane helices predicted by TMHMM2.0 59919004980 1 probable transmembrane helix predicted by TMHMM2.0 59919004981 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 59919004982 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 59919004983 ATP binding site [chemical binding]; other site 59919004984 Mg2+ binding site [ion binding]; other site 59919004985 G-X-G motif; other site 59919004986 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 59919004987 anchoring element; other site 59919004988 dimer interface [polypeptide binding]; other site 59919004989 ATP binding site [chemical binding]; other site 59919004990 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 59919004991 active site 59919004992 putative metal-binding site [ion binding]; other site 59919004993 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 59919004994 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 59919004995 tRNA dimethylallyltransferase; Region: miaA; TIGR00174 59919004996 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 59919004997 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 59919004998 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 59919004999 Predicted transcriptional regulators [Transcription]; Region: COG1725 59919005000 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 59919005001 DNA-binding site [nucleotide binding]; DNA binding site 59919005002 serine O-acetyltransferase; Region: cysE; TIGR01172 59919005003 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 59919005004 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 59919005005 trimer interface [polypeptide binding]; other site 59919005006 active site 59919005007 substrate binding site [chemical binding]; other site 59919005008 CoA binding site [chemical binding]; other site 59919005009 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12902 59919005010 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 59919005011 ATP binding site [chemical binding]; other site 59919005012 putative Mg++ binding site [ion binding]; other site 59919005013 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 59919005014 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 59919005015 Coenzyme A binding pocket [chemical binding]; other site 59919005016 GtrA-like protein; Region: GtrA; pfam04138 59919005017 4 probable transmembrane helices predicted by TMHMM2.0 59919005018 SnoaL-like domain; Region: SnoaL_2; pfam12680 59919005019 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 59919005020 homopentamer interface [polypeptide binding]; other site 59919005021 active site 59919005022 photosystem II core protein PsbZ; Region: PS_II_psbZ; TIGR03043 59919005023 2 probable transmembrane helices predicted by TMHMM2.0 59919005024 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 59919005025 MutS domain I; Region: MutS_I; pfam01624 59919005026 MutS domain II; Region: MutS_II; pfam05188 59919005027 MutS domain III; Region: MutS_III; pfam05192 59919005028 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 59919005029 Walker A/P-loop; other site 59919005030 ATP binding site [chemical binding]; other site 59919005031 Q-loop/lid; other site 59919005032 ABC transporter signature motif; other site 59919005033 Walker B; other site 59919005034 D-loop; other site 59919005035 H-loop/switch region; other site 59919005036 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 59919005037 Precorrin-8X methylmutase; Region: CbiC; pfam02570 59919005038 DNA polymerase III subunit delta; Validated; Region: PRK07452 59919005039 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 59919005040 aspartate kinase; Provisional; Region: PRK07431 59919005041 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 59919005042 putative nucleotide binding site [chemical binding]; other site 59919005043 putative catalytic residues [active] 59919005044 putative Mg ion binding site [ion binding]; other site 59919005045 putative aspartate binding site [chemical binding]; other site 59919005046 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 59919005047 putative allosteric regulatory site; other site 59919005048 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 59919005049 putative allosteric regulatory residue; other site 59919005050 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 59919005051 putative allosteric regulatory site; other site 59919005052 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 59919005053 putative allosteric regulatory residue; other site 59919005054 excinuclease ABC subunit B; Provisional; Region: PRK05298 59919005055 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 59919005056 ATP binding site [chemical binding]; other site 59919005057 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 59919005058 putative Mg++ binding site [ion binding]; other site 59919005059 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 59919005060 nucleotide binding region [chemical binding]; other site 59919005061 ATP-binding site [chemical binding]; other site 59919005062 Ultra-violet resistance protein B; Region: UvrB; pfam12344 59919005063 UvrB/uvrC motif; Region: UVR; pfam02151 59919005064 Protein of unknown function (DUF561); Region: DUF561; pfam04481 59919005065 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 59919005066 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 59919005067 Ligand Binding Site [chemical binding]; other site 59919005068 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 59919005069 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 59919005070 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 59919005071 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 59919005072 dihydrodipicolinate synthase; Region: dapA; TIGR00674 59919005073 dimer interface [polypeptide binding]; other site 59919005074 active site 59919005075 catalytic residue [active] 59919005076 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 59919005077 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 59919005078 trigger factor; Provisional; Region: tig; PRK01490 59919005079 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 59919005080 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 59919005081 Clp protease; Region: CLP_protease; pfam00574 59919005082 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 59919005083 oligomer interface [polypeptide binding]; other site 59919005084 active site residues [active] 59919005085 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 59919005086 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 59919005087 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 59919005088 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 59919005089 Walker A motif; other site 59919005090 ATP binding site [chemical binding]; other site 59919005091 Walker B motif; other site 59919005092 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 59919005093 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14948 59919005094 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 59919005095 Walker A motif; other site 59919005096 ATP binding site [chemical binding]; other site 59919005097 Walker B motif; other site 59919005098 arginine finger; other site 59919005099 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 59919005100 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 59919005101 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 59919005102 DXD motif; other site 59919005103 5 probable transmembrane helices predicted by TMHMM2.0 59919005104 Sporulation related domain; Region: SPOR; cl10051 59919005105 Stage II sporulation protein; Region: SpoIID; pfam08486 59919005106 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 59919005107 1 probable transmembrane helix predicted by TMHMM2.0 59919005108 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 59919005109 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 59919005110 23S rRNA binding site [nucleotide binding]; other site 59919005111 L21 binding site [polypeptide binding]; other site 59919005112 L13 binding site [polypeptide binding]; other site 59919005113 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 59919005114 binding surface 59919005115 TPR motif; other site 59919005116 TPR repeat; Region: TPR_11; pfam13414 59919005117 1 probable transmembrane helix predicted by TMHMM2.0 59919005118 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 59919005119 ThiS interaction site; other site 59919005120 putative active site [active] 59919005121 tetramer interface [polypeptide binding]; other site 59919005122 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 59919005123 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 59919005124 NAD(P) binding site [chemical binding]; other site 59919005125 active site 59919005126 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 59919005127 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 59919005128 glycine dehydrogenase; Provisional; Region: PRK05367 59919005129 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 59919005130 tetramer interface [polypeptide binding]; other site 59919005131 pyridoxal 5'-phosphate binding site [chemical binding]; other site 59919005132 catalytic residue [active] 59919005133 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 59919005134 tetramer interface [polypeptide binding]; other site 59919005135 pyridoxal 5'-phosphate binding site [chemical binding]; other site 59919005136 catalytic residue [active] 59919005137 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 59919005138 lipoyl attachment site [posttranslational modification]; other site 59919005139 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 59919005140 Aluminium resistance protein; Region: Alum_res; pfam06838 59919005141 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 59919005142 Fatty acid desaturase; Region: FA_desaturase; pfam00487 59919005143 Di-iron ligands [ion binding]; other site 59919005144 4 probable transmembrane helices predicted by TMHMM2.0 59919005145 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 59919005146 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 59919005147 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 59919005148 replicative DNA helicase; Region: DnaB; TIGR00665 59919005149 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 59919005150 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 59919005151 Walker A motif; other site 59919005152 ATP binding site [chemical binding]; other site 59919005153 Walker B motif; other site 59919005154 DNA binding loops [nucleotide binding] 59919005155 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 59919005156 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 59919005157 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 59919005158 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 59919005159 Protein of unknown function (DUF98); Region: DUF98; pfam01947 59919005160 SprT-like family; Region: SprT-like; pfam10263 59919005161 SprT homologues; Region: SprT; cl01182 59919005162 1 probable transmembrane helix predicted by TMHMM2.0 59919005163 DNA ligase; Provisional; Region: 30; PHA02587 59919005164 Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015 59919005165 active site 59919005166 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of kDNA ligase-like ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_kDNA_ligase_like; cd08041 59919005167 DNA binding site [nucleotide binding] 59919005168 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 59919005169 4 probable transmembrane helices predicted by TMHMM2.0 59919005170 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 59919005171 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 59919005172 active site 59919005173 HIGH motif; other site 59919005174 nucleotide binding site [chemical binding]; other site 59919005175 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 59919005176 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 59919005177 active site 59919005178 KMSKS motif; other site 59919005179 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 59919005180 tRNA binding surface [nucleotide binding]; other site 59919005181 anticodon binding site; other site 59919005182 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 59919005183 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 59919005184 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 59919005185 homodimer interface [polypeptide binding]; other site 59919005186 metal binding site [ion binding]; metal-binding site 59919005187 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 59919005188 homodimer interface [polypeptide binding]; other site 59919005189 active site 59919005190 putative chemical substrate binding site [chemical binding]; other site 59919005191 metal binding site [ion binding]; metal-binding site 59919005192 spermidine synthase; Provisional; Region: PRK00811 59919005193 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 59919005194 S-adenosylmethionine binding site [chemical binding]; other site 59919005195 agmatinase; Region: agmatinase; TIGR01230 59919005196 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 59919005197 putative active site [active] 59919005198 Mn binding site [ion binding]; other site 59919005199 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 59919005200 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 59919005201 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 59919005202 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 59919005203 dimer interface [polypeptide binding]; other site 59919005204 anticodon binding site; other site 59919005205 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 59919005206 homodimer interface [polypeptide binding]; other site 59919005207 motif 1; other site 59919005208 active site 59919005209 motif 2; other site 59919005210 GAD domain; Region: GAD; pfam02938 59919005211 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 59919005212 active site 59919005213 motif 3; other site 59919005214 CTP synthetase; Validated; Region: pyrG; PRK05380 59919005215 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 59919005216 Catalytic site [active] 59919005217 active site 59919005218 UTP binding site [chemical binding]; other site 59919005219 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 59919005220 active site 59919005221 putative oxyanion hole; other site 59919005222 catalytic triad [active] 59919005223 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 59919005224 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 59919005225 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 59919005226 Ligand Binding Site [chemical binding]; other site 59919005227 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 59919005228 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 59919005229 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 59919005230 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 59919005231 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 59919005232 homodimer interface [polypeptide binding]; other site 59919005233 substrate-cofactor binding pocket; other site 59919005234 pyridoxal 5'-phosphate binding site [chemical binding]; other site 59919005235 catalytic residue [active] 59919005236 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 59919005237 active site 59919005238 SAM binding site [chemical binding]; other site 59919005239 homodimer interface [polypeptide binding]; other site 59919005240 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 59919005241 Major Facilitator Superfamily; Region: MFS_1; pfam07690 59919005242 putative substrate translocation pore; other site 59919005243 8 probable transmembrane helices predicted by TMHMM2.0 59919005244 polyphosphate kinase; Provisional; Region: PRK05443 59919005245 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 59919005246 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 59919005247 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 59919005248 putative domain interface [polypeptide binding]; other site 59919005249 putative active site [active] 59919005250 catalytic site [active] 59919005251 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 59919005252 putative domain interface [polypeptide binding]; other site 59919005253 putative active site [active] 59919005254 catalytic site [active] 59919005255 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 59919005256 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 59919005257 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 59919005258 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 59919005259 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 59919005260 DNA binding residues [nucleotide binding] 59919005261 Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170 59919005262 4 probable transmembrane helices predicted by TMHMM2.0 59919005263 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 59919005264 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 59919005265 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 59919005266 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 59919005267 substrate binding site [chemical binding]; other site 59919005268 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 59919005269 substrate binding site [chemical binding]; other site 59919005270 ligand binding site [chemical binding]; other site 59919005271 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 59919005272 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 59919005273 Cl- selectivity filter; other site 59919005274 Cl- binding residues [ion binding]; other site 59919005275 pore gating glutamate residue; other site 59919005276 dimer interface [polypeptide binding]; other site 59919005277 H+/Cl- coupling transport residue; other site 59919005278 10 probable transmembrane helices predicted by TMHMM2.0 59919005279 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 59919005280 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 59919005281 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 59919005282 putative active site [active] 59919005283 putative substrate binding site [chemical binding]; other site 59919005284 putative cosubstrate binding site; other site 59919005285 catalytic site [active] 59919005286 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 59919005287 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 59919005288 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 59919005289 nucleotide binding site [chemical binding]; other site 59919005290 NEF interaction site [polypeptide binding]; other site 59919005291 SBD interface [polypeptide binding]; other site 59919005292 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 59919005293 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 59919005294 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 59919005295 NAD(P) binding site [chemical binding]; other site 59919005296 shikimate binding site; other site 59919005297 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 59919005298 argininosuccinate synthase; Provisional; Region: PRK13820 59919005299 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 59919005300 ANP binding site [chemical binding]; other site 59919005301 Substrate Binding Site II [chemical binding]; other site 59919005302 Substrate Binding Site I [chemical binding]; other site 59919005303 Protein of unknown function (DUF3134); Region: DUF3134; pfam11332 59919005304 phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445 59919005305 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 59919005306 Mg++ binding site [ion binding]; other site 59919005307 putative catalytic motif [active] 59919005308 putative substrate binding site [chemical binding]; other site 59919005309 8 probable transmembrane helices predicted by TMHMM2.0 59919005310 sucrose-phosphate synthase, putative, glycosyltransferase domain; Region: sucr_P_syn_N; TIGR02472 59919005311 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 59919005312 putative ADP-binding pocket [chemical binding]; other site 59919005313 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 59919005314 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 59919005315 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 59919005316 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 59919005317 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 59919005318 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 59919005319 Walker A/P-loop; other site 59919005320 ATP binding site [chemical binding]; other site 59919005321 Q-loop/lid; other site 59919005322 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 59919005323 ABC transporter signature motif; other site 59919005324 Walker B; other site 59919005325 D-loop; other site 59919005326 H-loop/switch region; other site 59919005327 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 59919005328 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 59919005329 active site 59919005330 substrate binding site [chemical binding]; other site 59919005331 ATP binding site [chemical binding]; other site 59919005332 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 59919005333 threonine synthase; Reviewed; Region: PRK06721 59919005334 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 59919005335 homodimer interface [polypeptide binding]; other site 59919005336 pyridoxal 5'-phosphate binding site [chemical binding]; other site 59919005337 catalytic residue [active]