-- dump date 20140620_000548 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1171373000001 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 1171373000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1171373000003 Walker A motif; other site 1171373000004 ATP binding site [chemical binding]; other site 1171373000005 Walker B motif; other site 1171373000006 arginine finger; other site 1171373000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1171373000008 DnaA box-binding interface [nucleotide binding]; other site 1171373000009 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1171373000010 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1171373000011 Walker A/P-loop; other site 1171373000012 ATP binding site [chemical binding]; other site 1171373000013 Q-loop/lid; other site 1171373000014 ABC transporter signature motif; other site 1171373000015 Walker B; other site 1171373000016 D-loop; other site 1171373000017 H-loop/switch region; other site 1171373000018 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1171373000019 FtsX-like permease family; Region: FtsX; pfam02687 1171373000020 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1171373000021 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1171373000022 FtsX-like permease family; Region: FtsX; pfam02687 1171373000023 DNA polymerase III subunit beta; Validated; Region: PRK07761 1171373000024 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1171373000025 putative DNA binding surface [nucleotide binding]; other site 1171373000026 dimer interface [polypeptide binding]; other site 1171373000027 beta-clamp/clamp loader binding surface; other site 1171373000028 beta-clamp/translesion DNA polymerase binding surface; other site 1171373000029 recombination protein F; Reviewed; Region: recF; PRK00064 1171373000030 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1171373000031 Walker A/P-loop; other site 1171373000032 ATP binding site [chemical binding]; other site 1171373000033 Q-loop/lid; other site 1171373000034 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1171373000035 ABC transporter signature motif; other site 1171373000036 Walker B; other site 1171373000037 D-loop; other site 1171373000038 H-loop/switch region; other site 1171373000039 Protein of unknown function (DUF721); Region: DUF721; cl02324 1171373000040 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1171373000041 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1171373000042 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1171373000043 Mg2+ binding site [ion binding]; other site 1171373000044 G-X-G motif; other site 1171373000045 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1171373000046 anchoring element; other site 1171373000047 dimer interface [polypeptide binding]; other site 1171373000048 ATP binding site [chemical binding]; other site 1171373000049 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1171373000050 active site 1171373000051 putative metal-binding site [ion binding]; other site 1171373000052 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1171373000053 DNA gyrase subunit A; Validated; Region: PRK05560 1171373000054 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1171373000055 CAP-like domain; other site 1171373000056 active site 1171373000057 primary dimer interface [polypeptide binding]; other site 1171373000058 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1171373000059 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1171373000060 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1171373000061 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1171373000062 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1171373000063 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 1171373000064 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1171373000065 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1171373000066 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1171373000067 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1171373000068 DNA binding site [nucleotide binding] 1171373000069 domain linker motif; other site 1171373000070 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1171373000071 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1171373000072 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1171373000073 Walker A/P-loop; other site 1171373000074 ATP binding site [chemical binding]; other site 1171373000075 Q-loop/lid; other site 1171373000076 ABC transporter signature motif; other site 1171373000077 Walker B; other site 1171373000078 D-loop; other site 1171373000079 H-loop/switch region; other site 1171373000080 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1171373000081 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1171373000082 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1171373000083 TM-ABC transporter signature motif; other site 1171373000084 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 1171373000085 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 1171373000086 ligand binding site [chemical binding]; other site 1171373000087 dimerization interface [polypeptide binding]; other site 1171373000088 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1171373000089 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1171373000090 substrate binding site [chemical binding]; other site 1171373000091 dimer interface [polypeptide binding]; other site 1171373000092 ATP binding site [chemical binding]; other site 1171373000093 D-ribose pyranase; Provisional; Region: PRK11797 1171373000094 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1171373000095 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1171373000096 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 1171373000097 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1171373000098 Walker A/P-loop; other site 1171373000099 ATP binding site [chemical binding]; other site 1171373000100 Q-loop/lid; other site 1171373000101 ABC transporter signature motif; other site 1171373000102 Walker B; other site 1171373000103 D-loop; other site 1171373000104 H-loop/switch region; other site 1171373000105 Protein of unknown function (DUF1048); Region: DUF1048; cl01986 1171373000106 Predicted transcriptional regulators [Transcription]; Region: COG1695 1171373000107 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1171373000108 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12748 1171373000109 classical (c) SDRs; Region: SDR_c; cd05233 1171373000110 NAD(P) binding site [chemical binding]; other site 1171373000111 active site 1171373000112 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1171373000113 non-specific DNA binding site [nucleotide binding]; other site 1171373000114 salt bridge; other site 1171373000115 sequence-specific DNA binding site [nucleotide binding]; other site 1171373000116 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 1171373000117 putative active site [active] 1171373000118 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1171373000119 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1171373000120 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1171373000121 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 1171373000122 transmembrane helices; other site 1171373000123 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1171373000124 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1171373000125 putative substrate translocation pore; other site 1171373000126 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 1171373000127 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 1171373000128 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 1171373000129 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 1171373000130 NAD(P) binding site [chemical binding]; other site 1171373000131 LDH/MDH dimer interface [polypeptide binding]; other site 1171373000132 substrate binding site [chemical binding]; other site 1171373000133 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1171373000134 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 1171373000135 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1171373000136 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1171373000137 Beta galactosidase small chain; Region: Bgal_small_N; cl03787 1171373000138 acetolactate synthase; Reviewed; Region: PRK08322 1171373000139 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1171373000140 PYR/PP interface [polypeptide binding]; other site 1171373000141 dimer interface [polypeptide binding]; other site 1171373000142 TPP binding site [chemical binding]; other site 1171373000143 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1171373000144 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 1171373000145 TPP-binding site [chemical binding]; other site 1171373000146 dimer interface [polypeptide binding]; other site 1171373000147 malate dehydrogenase; Provisional; Region: PRK13529 1171373000148 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1171373000149 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1171373000150 NAD(P) binding site [chemical binding]; other site 1171373000151 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 1171373000152 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 1171373000153 LDH/MDH dimer interface [polypeptide binding]; other site 1171373000154 NAD(P) binding site [chemical binding]; other site 1171373000155 substrate binding site [chemical binding]; other site 1171373000156 pyruvate carboxylase; Reviewed; Region: PRK12999 1171373000157 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1171373000158 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1171373000159 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1171373000160 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1171373000161 active site 1171373000162 catalytic residues [active] 1171373000163 metal binding site [ion binding]; metal-binding site 1171373000164 homodimer binding site [polypeptide binding]; other site 1171373000165 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1171373000166 carboxyltransferase (CT) interaction site; other site 1171373000167 biotinylation site [posttranslational modification]; other site 1171373000168 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1171373000169 substrate binding site [chemical binding]; other site 1171373000170 THF binding site; other site 1171373000171 zinc-binding site [ion binding]; other site 1171373000172 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1171373000173 Coenzyme A binding pocket [chemical binding]; other site 1171373000174 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1171373000175 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1171373000176 active site 1171373000177 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK07111 1171373000178 ATP cone domain; Region: ATP-cone; pfam03477 1171373000179 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1171373000180 Class III ribonucleotide reductase; Region: RNR_III; cd01675 1171373000181 active site 1171373000182 Zn binding site [ion binding]; other site 1171373000183 glycine loop; other site 1171373000184 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 1171373000185 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 1171373000186 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1171373000187 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 1171373000188 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 1171373000189 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1171373000190 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1171373000191 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 1171373000192 Walker A/P-loop; other site 1171373000193 ATP binding site [chemical binding]; other site 1171373000194 Q-loop/lid; other site 1171373000195 ABC transporter signature motif; other site 1171373000196 Walker B; other site 1171373000197 D-loop; other site 1171373000198 H-loop/switch region; other site 1171373000199 MoxR-like ATPases [General function prediction only]; Region: COG0714 1171373000200 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1171373000201 Protein of unknown function DUF58; Region: DUF58; pfam01882 1171373000202 von Willebrand factor type A domain; Region: VWA_2; pfam13519 1171373000203 metal ion-dependent adhesion site (MIDAS); other site 1171373000204 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1171373000205 metal ion-dependent adhesion site (MIDAS); other site 1171373000206 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 1171373000207 DDE superfamily endonuclease; Region: DDE_4; cl17710 1171373000208 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 1171373000209 active site 1171373000210 catalytic triad [active] 1171373000211 oxyanion hole [active] 1171373000212 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 1171373000213 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1171373000214 MULE transposase domain; Region: MULE; pfam10551 1171373000215 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 1171373000216 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1171373000217 sequence-specific DNA binding site [nucleotide binding]; other site 1171373000218 salt bridge; other site 1171373000219 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 1171373000220 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 1171373000221 dimer interface [polypeptide binding]; other site 1171373000222 [2Fe-2S] cluster binding site [ion binding]; other site 1171373000223 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1171373000224 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1171373000225 Walker A/P-loop; other site 1171373000226 ATP binding site [chemical binding]; other site 1171373000227 Q-loop/lid; other site 1171373000228 ABC transporter signature motif; other site 1171373000229 Walker B; other site 1171373000230 D-loop; other site 1171373000231 H-loop/switch region; other site 1171373000232 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1171373000233 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1171373000234 ABC-ATPase subunit interface; other site 1171373000235 dimer interface [polypeptide binding]; other site 1171373000236 putative PBP binding regions; other site 1171373000237 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 1171373000238 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1171373000239 intersubunit interface [polypeptide binding]; other site 1171373000240 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 1171373000241 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1171373000242 Domain of unknown function (DUF305); Region: DUF305; cl17794 1171373000243 Domain of unknown function (DUF305); Region: DUF305; pfam03713 1171373000244 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1171373000245 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1171373000246 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 1171373000247 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1171373000248 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1171373000249 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases [Carbohydrate transport and metabolism]; Region: AraD; COG0235 1171373000250 intersubunit interface [polypeptide binding]; other site 1171373000251 active site 1171373000252 Zn2+ binding site [ion binding]; other site 1171373000253 putative frv operon regulatory protein; Provisional; Region: PRK09863 1171373000254 PRD domain; Region: PRD; pfam00874 1171373000255 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1171373000256 active site 1171373000257 P-loop; other site 1171373000258 phosphorylation site [posttranslational modification] 1171373000259 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1171373000260 active site 1171373000261 phosphorylation site [posttranslational modification] 1171373000262 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1171373000263 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1171373000264 NAD(P) binding site [chemical binding]; other site 1171373000265 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 1171373000266 active site 1171373000267 P-loop; other site 1171373000268 phosphorylation site [posttranslational modification] 1171373000269 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 1171373000270 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1171373000271 active site 1171373000272 phosphorylation site [posttranslational modification] 1171373000273 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 1171373000274 additional DNA contacts [nucleotide binding]; other site 1171373000275 mismatch recognition site; other site 1171373000276 active site 1171373000277 zinc binding site [ion binding]; other site 1171373000278 DNA intercalation site [nucleotide binding]; other site 1171373000279 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1171373000280 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 1171373000281 cofactor binding site; other site 1171373000282 DNA binding site [nucleotide binding] 1171373000283 substrate interaction site [chemical binding]; other site 1171373000284 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1171373000285 uncharacterized ygcE-like proteins; Region: FGGY_ygcE_like; cd07779 1171373000286 putative N- and C-terminal domain interface [polypeptide binding]; other site 1171373000287 putative active site [active] 1171373000288 MgATP binding site [chemical binding]; other site 1171373000289 catalytic site [active] 1171373000290 metal binding site [ion binding]; metal-binding site 1171373000291 putative carbohydrate binding site [chemical binding]; other site 1171373000292 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GpsA; COG0240 1171373000293 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1171373000294 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1171373000295 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 1171373000296 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1171373000297 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1171373000298 active site 1171373000299 motif I; other site 1171373000300 motif II; other site 1171373000301 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1171373000302 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1171373000303 Walker A/P-loop; other site 1171373000304 ATP binding site [chemical binding]; other site 1171373000305 Q-loop/lid; other site 1171373000306 ABC transporter signature motif; other site 1171373000307 Walker B; other site 1171373000308 D-loop; other site 1171373000309 H-loop/switch region; other site 1171373000310 Predicted transcriptional regulators [Transcription]; Region: COG1725 1171373000311 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1171373000312 DNA-binding site [nucleotide binding]; DNA binding site 1171373000313 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1171373000314 enolase; Provisional; Region: eno; PRK00077 1171373000315 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1171373000316 dimer interface [polypeptide binding]; other site 1171373000317 metal binding site [ion binding]; metal-binding site 1171373000318 substrate binding pocket [chemical binding]; other site 1171373000319 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1171373000320 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1171373000321 substrate binding pocket [chemical binding]; other site 1171373000322 membrane-bound complex binding site; other site 1171373000323 hinge residues; other site 1171373000324 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1171373000325 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1171373000326 substrate binding pocket [chemical binding]; other site 1171373000327 membrane-bound complex binding site; other site 1171373000328 hinge residues; other site 1171373000329 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1171373000330 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1171373000331 dimer interface [polypeptide binding]; other site 1171373000332 conserved gate region; other site 1171373000333 putative PBP binding loops; other site 1171373000334 ABC-ATPase subunit interface; other site 1171373000335 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1171373000336 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1171373000337 Walker A/P-loop; other site 1171373000338 ATP binding site [chemical binding]; other site 1171373000339 Q-loop/lid; other site 1171373000340 ABC transporter signature motif; other site 1171373000341 Walker B; other site 1171373000342 D-loop; other site 1171373000343 H-loop/switch region; other site 1171373000344 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 1171373000345 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1171373000346 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1171373000347 homodimer interface [polypeptide binding]; other site 1171373000348 catalytic residue [active] 1171373000349 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 1171373000350 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 1171373000351 active site 1171373000352 nucleophile elbow; other site 1171373000353 carbohydrate ABC transporter, N-acetylglucosamine/diacetylchitobiose-binding protein; Region: chitin_NgcE; TIGR03851 1171373000354 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1171373000355 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1171373000356 dimer interface [polypeptide binding]; other site 1171373000357 conserved gate region; other site 1171373000358 putative PBP binding loops; other site 1171373000359 ABC-ATPase subunit interface; other site 1171373000360 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1171373000361 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1171373000362 dimer interface [polypeptide binding]; other site 1171373000363 conserved gate region; other site 1171373000364 putative PBP binding loops; other site 1171373000365 ABC-ATPase subunit interface; other site 1171373000366 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1171373000367 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 1171373000368 phosphate binding site [ion binding]; other site 1171373000369 Protein of unknown function (DUF4127); Region: DUF4127; pfam13552 1171373000370 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 1171373000371 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1171373000372 putative active site [active] 1171373000373 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1171373000374 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1171373000375 Coenzyme A binding pocket [chemical binding]; other site 1171373000376 SAF domain; Region: SAF; pfam08666 1171373000377 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 1171373000378 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1171373000379 Walker A motif; other site 1171373000380 ATP binding site [chemical binding]; other site 1171373000381 Walker B motif; other site 1171373000382 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 1171373000383 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1171373000384 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1171373000385 Bacterial transcriptional activator domain; Region: BTAD; smart01043 1171373000386 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1171373000387 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1171373000388 NAD(P) binding site [chemical binding]; other site 1171373000389 catalytic residues [active] 1171373000390 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 1171373000391 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1171373000392 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1171373000393 H+ Antiporter protein; Region: 2A0121; TIGR00900 1171373000394 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1171373000395 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1171373000396 DNA binding residues [nucleotide binding] 1171373000397 dimerization interface [polypeptide binding]; other site 1171373000398 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1171373000399 active site 1171373000400 NTP binding site [chemical binding]; other site 1171373000401 metal binding triad [ion binding]; metal-binding site 1171373000402 antibiotic binding site [chemical binding]; other site 1171373000403 Protein of unknown function DUF86; Region: DUF86; cl01031 1171373000404 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 1171373000405 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 1171373000406 Potassium binding sites [ion binding]; other site 1171373000407 Cesium cation binding sites [ion binding]; other site 1171373000408 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 1171373000409 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1171373000410 FtsX-like permease family; Region: FtsX; pfam02687 1171373000411 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1171373000412 FtsX-like permease family; Region: FtsX; pfam02687 1171373000413 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1171373000414 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1171373000415 Walker A/P-loop; other site 1171373000416 ATP binding site [chemical binding]; other site 1171373000417 Q-loop/lid; other site 1171373000418 ABC transporter signature motif; other site 1171373000419 Walker B; other site 1171373000420 D-loop; other site 1171373000421 H-loop/switch region; other site 1171373000422 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1171373000423 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1171373000424 active site 1171373000425 phosphorylation site [posttranslational modification] 1171373000426 intermolecular recognition site; other site 1171373000427 dimerization interface [polypeptide binding]; other site 1171373000428 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1171373000429 DNA binding residues [nucleotide binding] 1171373000430 dimerization interface [polypeptide binding]; other site 1171373000431 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1171373000432 non-specific DNA binding site [nucleotide binding]; other site 1171373000433 salt bridge; other site 1171373000434 sequence-specific DNA binding site [nucleotide binding]; other site 1171373000435 Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681 1171373000436 putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683 1171373000437 hypothetical protein; Reviewed; Region: PRK09588 1171373000438 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 1171373000439 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1171373000440 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1171373000441 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1171373000442 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1171373000443 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1171373000444 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1171373000445 Walker A/P-loop; other site 1171373000446 ATP binding site [chemical binding]; other site 1171373000447 Q-loop/lid; other site 1171373000448 ABC transporter signature motif; other site 1171373000449 Walker B; other site 1171373000450 D-loop; other site 1171373000451 H-loop/switch region; other site 1171373000452 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1171373000453 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1171373000454 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1171373000455 dimerization interface [polypeptide binding]; other site 1171373000456 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1171373000457 dimer interface [polypeptide binding]; other site 1171373000458 phosphorylation site [posttranslational modification] 1171373000459 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1171373000460 ATP binding site [chemical binding]; other site 1171373000461 Mg2+ binding site [ion binding]; other site 1171373000462 G-X-G motif; other site 1171373000463 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1171373000464 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1171373000465 Domain of unknown function (DUF4153); Region: DUF4153; pfam13687 1171373000466 Histidine kinase; Region: HisKA_3; pfam07730 1171373000467 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1171373000468 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1171373000469 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1171373000470 dimerization interface [polypeptide binding]; other site 1171373000471 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1171373000472 dimer interface [polypeptide binding]; other site 1171373000473 phosphorylation site [posttranslational modification] 1171373000474 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1171373000475 ATP binding site [chemical binding]; other site 1171373000476 Mg2+ binding site [ion binding]; other site 1171373000477 G-X-G motif; other site 1171373000478 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 1171373000479 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1171373000480 active site 1171373000481 phosphorylation site [posttranslational modification] 1171373000482 intermolecular recognition site; other site 1171373000483 dimerization interface [polypeptide binding]; other site 1171373000484 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1171373000485 DNA binding site [nucleotide binding] 1171373000486 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1171373000487 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1171373000488 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1171373000489 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1171373000490 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1171373000491 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1171373000492 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1171373000493 catalytic residues [active] 1171373000494 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1171373000495 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1171373000496 NAD(P) binding site [chemical binding]; other site 1171373000497 active site 1171373000498 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1171373000499 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1171373000500 Active Sites [active] 1171373000501 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1171373000502 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1171373000503 Active Sites [active] 1171373000504 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 1171373000505 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1171373000506 putative GEF interaction site [polypeptide binding]; other site 1171373000507 G1 box; other site 1171373000508 GTP/Mg2+ binding site [chemical binding]; other site 1171373000509 Switch I region; other site 1171373000510 G2 box; other site 1171373000511 CysD dimerization site [polypeptide binding]; other site 1171373000512 G3 box; other site 1171373000513 Switch II region; other site 1171373000514 G4 box; other site 1171373000515 G5 box; other site 1171373000516 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1171373000517 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1171373000518 Predicted permeases [General function prediction only]; Region: COG0730 1171373000519 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1171373000520 AsnC family; Region: AsnC_trans_reg; pfam01037 1171373000521 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 1171373000522 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1171373000523 metal binding site [ion binding]; metal-binding site 1171373000524 Protein of unknown function (DUF3100); Region: DUF3100; pfam11299 1171373000525 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1171373000526 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1171373000527 active site 1171373000528 catalytic tetrad [active] 1171373000529 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1171373000530 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1171373000531 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1171373000532 non-specific DNA binding site [nucleotide binding]; other site 1171373000533 salt bridge; other site 1171373000534 sequence-specific DNA binding site [nucleotide binding]; other site 1171373000535 Bacterial SH3 domain; Region: SH3_3; pfam08239 1171373000536 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1171373000537 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1171373000538 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1171373000539 nucleophilic elbow; other site 1171373000540 catalytic triad; other site 1171373000541 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1171373000542 thiS-thiF/thiG interaction site; other site 1171373000543 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1171373000544 ThiS interaction site; other site 1171373000545 putative active site [active] 1171373000546 tetramer interface [polypeptide binding]; other site 1171373000547 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 1171373000548 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1171373000549 ATP binding site [chemical binding]; other site 1171373000550 substrate interface [chemical binding]; other site 1171373000551 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1171373000552 active site residue [active] 1171373000553 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1171373000554 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1171373000555 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1171373000556 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1171373000557 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1171373000558 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1171373000559 MMPL family; Region: MMPL; pfam03176 1171373000560 MMPL family; Region: MMPL; pfam03176 1171373000561 Predicted membrane protein [Function unknown]; Region: COG1511 1171373000562 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1171373000563 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1171373000564 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1171373000565 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1171373000566 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 1171373000567 putative ADP-binding pocket [chemical binding]; other site 1171373000568 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1171373000569 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1171373000570 C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor; Region: CtBP_dh; cd05299 1171373000571 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1171373000572 ligand binding site [chemical binding]; other site 1171373000573 NAD binding site [chemical binding]; other site 1171373000574 catalytic site [active] 1171373000575 Transglycosylase; Region: Transgly; pfam00912 1171373000576 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1171373000577 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1171373000578 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 1171373000579 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 1171373000580 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1171373000581 putative substrate translocation pore; other site 1171373000582 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1171373000583 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1171373000584 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1171373000585 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1171373000586 putative substrate translocation pore; other site 1171373000587 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1171373000588 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 1171373000589 manganese transport protein MntH; Reviewed; Region: PRK00701 1171373000590 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1171373000591 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1171373000592 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 1171373000593 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1171373000594 FeoA domain; Region: FeoA; pfam04023 1171373000595 malate dehydrogenase; Provisional; Region: PRK13529 1171373000596 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1171373000597 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 1171373000598 NAD(P) binding pocket [chemical binding]; other site 1171373000599 Acylphosphatase; Region: Acylphosphatase; pfam00708 1171373000600 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 1171373000601 CoA binding domain; Region: CoA_binding_2; pfam13380 1171373000602 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 1171373000603 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 1171373000604 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 1171373000605 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 1171373000606 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1171373000607 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1171373000608 Oxaloacetate decarboxylase, gamma chain; Region: OAD_gamma; cl01458 1171373000609 putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK05641 1171373000610 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1171373000611 carboxyltransferase (CT) interaction site; other site 1171373000612 biotinylation site [posttranslational modification]; other site 1171373000613 Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883 1171373000614 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1171373000615 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 1171373000616 active site 1171373000617 substrate binding site [chemical binding]; other site 1171373000618 metal binding site [ion binding]; metal-binding site 1171373000619 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1171373000620 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1171373000621 Walker A/P-loop; other site 1171373000622 ATP binding site [chemical binding]; other site 1171373000623 Q-loop/lid; other site 1171373000624 ABC transporter signature motif; other site 1171373000625 Walker B; other site 1171373000626 D-loop; other site 1171373000627 H-loop/switch region; other site 1171373000628 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1171373000629 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1171373000630 tetramerization interface [polypeptide binding]; other site 1171373000631 NAD(P) binding site [chemical binding]; other site 1171373000632 catalytic residues [active] 1171373000633 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339 1171373000634 Predicted transcriptional regulator [General function prediction only]; Region: COG2522 1171373000635 6-phosphofructokinase; Provisional; Region: PRK03202 1171373000636 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1171373000637 active site 1171373000638 ADP/pyrophosphate binding site [chemical binding]; other site 1171373000639 dimerization interface [polypeptide binding]; other site 1171373000640 allosteric effector site; other site 1171373000641 fructose-1,6-bisphosphate binding site; other site 1171373000642 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 1171373000643 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1171373000644 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1171373000645 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1171373000646 dimer interface [polypeptide binding]; other site 1171373000647 conserved gate region; other site 1171373000648 putative PBP binding loops; other site 1171373000649 ABC-ATPase subunit interface; other site 1171373000650 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1171373000651 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1171373000652 dimer interface [polypeptide binding]; other site 1171373000653 conserved gate region; other site 1171373000654 putative PBP binding loops; other site 1171373000655 ABC-ATPase subunit interface; other site 1171373000656 Predicted transcriptional regulator [Transcription]; Region: COG2345 1171373000657 Helix-turn-helix domain; Region: HTH_20; pfam12840 1171373000658 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 1171373000659 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 1171373000660 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1171373000661 Uncharacterized conserved protein [Function unknown]; Region: COG3189 1171373000662 Domain of unknown function (DUF309); Region: DUF309; pfam03745 1171373000663 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 1171373000664 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1171373000665 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1171373000666 metal-binding site [ion binding] 1171373000667 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1171373000668 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1171373000669 ligand binding site [chemical binding]; other site 1171373000670 flexible hinge region; other site 1171373000671 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1171373000672 putative switch regulator; other site 1171373000673 non-specific DNA interactions [nucleotide binding]; other site 1171373000674 DNA binding site [nucleotide binding] 1171373000675 sequence specific DNA binding site [nucleotide binding]; other site 1171373000676 putative cAMP binding site [chemical binding]; other site 1171373000677 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1171373000678 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1171373000679 dimerization interface [polypeptide binding]; other site 1171373000680 DPS ferroxidase diiron center [ion binding]; other site 1171373000681 ion pore; other site 1171373000682 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 1171373000683 Predicted DNA-binding protein with an HTH domain [General function prediction only]; Region: COG4710 1171373000684 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1171373000685 Coenzyme A binding pocket [chemical binding]; other site 1171373000686 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 1171373000687 AAA domain; Region: AAA_14; pfam13173 1171373000688 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1171373000689 N-terminal domain interface [polypeptide binding]; other site 1171373000690 dimer interface [polypeptide binding]; other site 1171373000691 substrate binding pocket (H-site) [chemical binding]; other site 1171373000692 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 1171373000693 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1171373000694 N-terminal domain interface [polypeptide binding]; other site 1171373000695 dimer interface [polypeptide binding]; other site 1171373000696 substrate binding pocket (H-site) [chemical binding]; other site 1171373000697 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 1171373000698 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1171373000699 N-terminal domain interface [polypeptide binding]; other site 1171373000700 dimer interface [polypeptide binding]; other site 1171373000701 substrate binding pocket (H-site) [chemical binding]; other site 1171373000702 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1171373000703 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 1171373000704 putative dimer interface [polypeptide binding]; other site 1171373000705 N-terminal domain interface [polypeptide binding]; other site 1171373000706 putative substrate binding pocket (H-site) [chemical binding]; other site 1171373000707 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1171373000708 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1171373000709 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1171373000710 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1171373000711 Walker A/P-loop; other site 1171373000712 ATP binding site [chemical binding]; other site 1171373000713 Q-loop/lid; other site 1171373000714 ABC transporter signature motif; other site 1171373000715 Walker B; other site 1171373000716 D-loop; other site 1171373000717 H-loop/switch region; other site 1171373000718 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1171373000719 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1171373000720 Walker A/P-loop; other site 1171373000721 ATP binding site [chemical binding]; other site 1171373000722 Q-loop/lid; other site 1171373000723 ABC transporter signature motif; other site 1171373000724 Walker B; other site 1171373000725 D-loop; other site 1171373000726 H-loop/switch region; other site 1171373000727 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1171373000728 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1171373000729 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1171373000730 dimer interface [polypeptide binding]; other site 1171373000731 conserved gate region; other site 1171373000732 putative PBP binding loops; other site 1171373000733 ABC-ATPase subunit interface; other site 1171373000734 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1171373000735 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1171373000736 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1171373000737 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1171373000738 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1171373000739 Walker A/P-loop; other site 1171373000740 ATP binding site [chemical binding]; other site 1171373000741 Q-loop/lid; other site 1171373000742 ABC transporter signature motif; other site 1171373000743 Walker B; other site 1171373000744 D-loop; other site 1171373000745 H-loop/switch region; other site 1171373000746 TOBE domain; Region: TOBE; pfam03459 1171373000747 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1171373000748 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1171373000749 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 1171373000750 DNA binding residues [nucleotide binding] 1171373000751 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 1171373000752 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1171373000753 MPT binding site; other site 1171373000754 trimer interface [polypeptide binding]; other site 1171373000755 PemK-like protein; Region: PemK; pfam02452 1171373000756 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1171373000757 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1171373000758 active site 1171373000759 hybrid cluster protein; Provisional; Region: PRK05290 1171373000760 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1171373000761 ACS interaction site; other site 1171373000762 CODH interaction site; other site 1171373000763 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1171373000764 ACS interaction site; other site 1171373000765 CODH interaction site; other site 1171373000766 metal cluster binding site [ion binding]; other site 1171373000767 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1171373000768 FAD binding pocket [chemical binding]; other site 1171373000769 conserved FAD binding motif [chemical binding]; other site 1171373000770 phosphate binding motif [ion binding]; other site 1171373000771 beta-alpha-beta structure motif; other site 1171373000772 NAD binding pocket [chemical binding]; other site 1171373000773 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1171373000774 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1171373000775 Cytochrome P450; Region: p450; cl12078 1171373000776 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1171373000777 Integrase core domain; Region: rve; pfam00665 1171373000778 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1171373000779 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 1171373000780 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1171373000781 [4Fe-4S] binding site [ion binding]; other site 1171373000782 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1171373000783 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1171373000784 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1171373000785 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1171373000786 molybdopterin cofactor binding site; other site 1171373000787 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1171373000788 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 1171373000789 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 1171373000790 MarR family; Region: MarR_2; pfam12802 1171373000791 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1171373000792 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1171373000793 FeS/SAM binding site; other site 1171373000794 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1171373000795 Ubiquitin-like proteins; Region: UBQ; cl00155 1171373000796 charged pocket; other site 1171373000797 hydrophobic patch; other site 1171373000798 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1171373000799 MoaE homodimer interface [polypeptide binding]; other site 1171373000800 MoaD interaction [polypeptide binding]; other site 1171373000801 active site residues [active] 1171373000802 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1171373000803 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1171373000804 dimer interface [polypeptide binding]; other site 1171373000805 putative functional site; other site 1171373000806 putative MPT binding site; other site 1171373000807 MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor...; Region: MoaC; cl00242 1171373000808 trimer interface [polypeptide binding]; other site 1171373000809 dimer interface [polypeptide binding]; other site 1171373000810 putative active site [active] 1171373000811 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1171373000812 MPT binding site; other site 1171373000813 trimer interface [polypeptide binding]; other site 1171373000814 Predicted membrane protein [Function unknown]; Region: COG2364 1171373000815 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1171373000816 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1171373000817 dimer interface [polypeptide binding]; other site 1171373000818 substrate binding site [chemical binding]; other site 1171373000819 ATP binding site [chemical binding]; other site 1171373000820 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1171373000821 thiamine phosphate binding site [chemical binding]; other site 1171373000822 pyrophosphate binding site [ion binding]; other site 1171373000823 active site 1171373000824 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 1171373000825 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 1171373000826 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1171373000827 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1171373000828 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1171373000829 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1171373000830 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1171373000831 TM-ABC transporter signature motif; other site 1171373000832 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1171373000833 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1171373000834 TM-ABC transporter signature motif; other site 1171373000835 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1171373000836 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1171373000837 Walker A/P-loop; other site 1171373000838 ATP binding site [chemical binding]; other site 1171373000839 Q-loop/lid; other site 1171373000840 ABC transporter signature motif; other site 1171373000841 Walker B; other site 1171373000842 D-loop; other site 1171373000843 H-loop/switch region; other site 1171373000844 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1171373000845 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1171373000846 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1171373000847 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1171373000848 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1171373000849 DNA binding site [nucleotide binding] 1171373000850 domain linker motif; other site 1171373000851 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1171373000852 ligand binding site [chemical binding]; other site 1171373000853 dimerization interface [polypeptide binding]; other site 1171373000854 CHAP domain; Region: CHAP; pfam05257 1171373000855 Surface antigen [General function prediction only]; Region: COG3942 1171373000856 Peptidase family C69; Region: Peptidase_C69; pfam03577 1171373000857 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH6; cd08260 1171373000858 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1171373000859 putative NAD(P) binding site [chemical binding]; other site 1171373000860 catalytic Zn binding site [ion binding]; other site 1171373000861 structural Zn binding site [ion binding]; other site 1171373000862 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1171373000863 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1171373000864 NAD(P) binding site [chemical binding]; other site 1171373000865 catalytic residues [active] 1171373000866 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1171373000867 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1171373000868 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1171373000869 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1171373000870 DNA binding site [nucleotide binding] 1171373000871 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1171373000872 dimerization interface [polypeptide binding]; other site 1171373000873 ligand binding site [chemical binding]; other site 1171373000874 glucuronate isomerase; Reviewed; Region: PRK02925 1171373000875 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 1171373000876 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1171373000877 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1171373000878 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1171373000879 mannonate dehydratase; Provisional; Region: PRK03906 1171373000880 mannonate dehydratase; Region: uxuA; TIGR00695 1171373000881 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 1171373000882 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1171373000883 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1171373000884 active site 1171373000885 catalytic tetrad [active] 1171373000886 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1171373000887 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1171373000888 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1171373000889 catalytic residue [active] 1171373000890 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 1171373000891 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 1171373000892 metal binding site [ion binding]; metal-binding site 1171373000893 substrate binding pocket [chemical binding]; other site 1171373000894 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1171373000895 Uncharacterized conserved protein [Function unknown]; Region: COG3375 1171373000896 hypothetical protein; Provisional; Region: PRK07338 1171373000897 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 1171373000898 metal binding site [ion binding]; metal-binding site 1171373000899 dimer interface [polypeptide binding]; other site 1171373000900 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1171373000901 MgtC family; Region: MgtC; pfam02308 1171373000902 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1171373000903 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 1171373000904 Melibiase; Region: Melibiase; pfam02065 1171373000905 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1171373000906 DNA binding site [nucleotide binding] 1171373000907 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1171373000908 domain linker motif; other site 1171373000909 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1171373000910 dimerization interface [polypeptide binding]; other site 1171373000911 ligand binding site [chemical binding]; other site 1171373000912 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1171373000913 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 1171373000914 active site 1171373000915 catalytic site [active] 1171373000916 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1171373000917 Protein of unknown function (DUF1778); Region: DUF1778; pfam08681 1171373000918 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1171373000919 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1171373000920 Uncharacterized conserved protein [Function unknown]; Region: COG1479 1171373000921 Protein of unknown function DUF262; Region: DUF262; pfam03235 1171373000922 Uncharacterized conserved protein [Function unknown]; Region: COG3472 1171373000923 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1171373000924 ATP binding site [chemical binding]; other site 1171373000925 putative Mg++ binding site [ion binding]; other site 1171373000926 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1171373000927 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1171373000928 nucleotide binding region [chemical binding]; other site 1171373000929 ATP-binding site [chemical binding]; other site 1171373000930 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 1171373000931 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1171373000932 ATP binding site [chemical binding]; other site 1171373000933 putative Mg++ binding site [ion binding]; other site 1171373000934 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1171373000935 ATP-binding site [chemical binding]; other site 1171373000936 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1171373000937 Family description; Region: UvrD_C_2; pfam13538 1171373000938 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1171373000939 Part of AAA domain; Region: AAA_19; pfam13245 1171373000940 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1171373000941 Homeodomain-like domain; Region: HTH_23; cl17451 1171373000942 Winged helix-turn helix; Region: HTH_29; pfam13551 1171373000943 Integrase core domain; Region: rve; pfam00665 1171373000944 Integrase core domain; Region: rve_3; pfam13683 1171373000945 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1171373000946 MULE transposase domain; Region: MULE; pfam10551 1171373000947 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1171373000948 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1171373000949 AAA domain; Region: AAA_14; pfam13173 1171373000950 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 1171373000951 stage V sporulation protein K; Region: spore_V_K; TIGR02881 1171373000952 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1171373000953 Walker A motif; other site 1171373000954 ATP binding site [chemical binding]; other site 1171373000955 Walker B motif; other site 1171373000956 arginine finger; other site 1171373000957 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1171373000958 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1171373000959 Walker A motif; other site 1171373000960 ATP binding site [chemical binding]; other site 1171373000961 Walker B motif; other site 1171373000962 arginine finger; other site 1171373000963 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1171373000964 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1171373000965 catalytic triad [active] 1171373000966 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1171373000967 Homeodomain-like domain; Region: HTH_23; pfam13384 1171373000968 Winged helix-turn helix; Region: HTH_29; pfam13551 1171373000969 Homeodomain-like domain; Region: HTH_32; pfam13565 1171373000970 Winged helix-turn helix; Region: HTH_33; pfam13592 1171373000971 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1171373000972 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1171373000973 hypothetical protein; Provisional; Region: PRK07907 1171373000974 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1171373000975 metal binding site [ion binding]; metal-binding site 1171373000976 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 1171373000977 active site 1171373000978 Zn binding site [ion binding]; other site 1171373000979 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1171373000980 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1171373000981 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1171373000982 D-xylulose kinase; Region: XylB; TIGR01312 1171373000983 nucleotide binding site [chemical binding]; other site 1171373000984 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1171373000985 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1171373000986 putative substrate translocation pore; other site 1171373000987 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1171373000988 xylose isomerase; Provisional; Region: PRK05474 1171373000989 xylose isomerase; Region: xylose_isom_A; TIGR02630 1171373000990 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1171373000991 non-specific DNA interactions [nucleotide binding]; other site 1171373000992 DNA binding site [nucleotide binding] 1171373000993 sequence specific DNA binding site [nucleotide binding]; other site 1171373000994 putative cAMP binding site [chemical binding]; other site 1171373000995 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1171373000996 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1171373000997 Peptidase family M23; Region: Peptidase_M23; pfam01551 1171373000998 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1171373000999 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 1171373001000 putative active site [active] 1171373001001 catalytic triad [active] 1171373001002 putative dimer interface [polypeptide binding]; other site 1171373001003 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1171373001004 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1171373001005 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1171373001006 Walker A/P-loop; other site 1171373001007 ATP binding site [chemical binding]; other site 1171373001008 Q-loop/lid; other site 1171373001009 ABC transporter signature motif; other site 1171373001010 Walker B; other site 1171373001011 D-loop; other site 1171373001012 H-loop/switch region; other site 1171373001013 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1171373001014 FtsX-like permease family; Region: FtsX; pfam02687 1171373001015 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1171373001016 HlyD family secretion protein; Region: HlyD_3; pfam13437 1171373001017 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 1171373001018 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1171373001019 FeS/SAM binding site; other site 1171373001020 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1171373001021 Sulfatase; Region: Sulfatase; cl17466 1171373001022 choline-sulfatase; Region: chol_sulfatase; TIGR03417 1171373001023 Choline sulfatase enzyme C terminal; Region: Choline_sulf_C; pfam12411 1171373001024 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1171373001025 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1171373001026 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1171373001027 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 1171373001028 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1171373001029 inhibitor-cofactor binding pocket; inhibition site 1171373001030 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1171373001031 catalytic residue [active] 1171373001032 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 1171373001033 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1171373001034 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 1171373001035 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1171373001036 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1171373001037 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1171373001038 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1171373001039 substrate binding site [chemical binding]; other site 1171373001040 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1171373001041 catalytic residue [active] 1171373001042 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1171373001043 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1171373001044 Bacterial transcriptional regulator; Region: IclR; pfam01614 1171373001045 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1171373001046 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1171373001047 DNA binding site [nucleotide binding] 1171373001048 domain linker motif; other site 1171373001049 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1171373001050 ligand binding site [chemical binding]; other site 1171373001051 dimerization interface [polypeptide binding]; other site 1171373001052 altronate oxidoreductase; Provisional; Region: PRK03643 1171373001053 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1171373001054 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1171373001055 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1171373001056 galactarate dehydratase; Region: galactar-dH20; TIGR03248 1171373001057 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1171373001058 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 1171373001059 Glucuronate isomerase; Region: UxaC; pfam02614 1171373001060 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1171373001061 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1171373001062 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 1171373001063 Glucuronate isomerase; Region: UxaC; cl00829 1171373001064 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1171373001065 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1171373001066 Transposase; Region: HTH_Tnp_1; cl17663 1171373001067 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1171373001068 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 1171373001069 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1171373001070 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1171373001071 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1171373001072 Helix-turn-helix domain; Region: HTH_38; pfam13936 1171373001073 Integrase core domain; Region: rve; pfam00665 1171373001074 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1171373001075 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1171373001076 NAD(P) binding site [chemical binding]; other site 1171373001077 active site 1171373001078 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1171373001079 MFS/sugar transport protein; Region: MFS_2; pfam13347 1171373001080 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 1171373001081 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1171373001082 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1171373001083 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1171373001084 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 1171373001085 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1171373001086 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1171373001087 MULE transposase domain; Region: MULE; pfam10551 1171373001088 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1171373001089 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1171373001090 catalytic residue [active] 1171373001091 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 1171373001092 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 1171373001093 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1171373001094 dimer interface [polypeptide binding]; other site 1171373001095 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1171373001096 catalytic residue [active] 1171373001097 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1171373001098 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1171373001099 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 1171373001100 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1171373001101 Walker A motif; other site 1171373001102 ATP binding site [chemical binding]; other site 1171373001103 Walker B motif; other site 1171373001104 arsenical pump-driving ATPase; Region: arsen_driv_ArsA; TIGR04291 1171373001105 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1171373001106 DTAP/Switch II; other site 1171373001107 Switch I; other site 1171373001108 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1171373001109 DTAP/Switch II; other site 1171373001110 Switch I; other site 1171373001111 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 1171373001112 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1171373001113 dimerization interface [polypeptide binding]; other site 1171373001114 putative DNA binding site [nucleotide binding]; other site 1171373001115 putative Zn2+ binding site [ion binding]; other site 1171373001116 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 1171373001117 Integrase core domain; Region: rve; pfam00665 1171373001118 Integrase core domain; Region: rve_3; pfam13683 1171373001119 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1171373001120 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1171373001121 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1171373001122 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1171373001123 putative substrate translocation pore; other site 1171373001124 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1171373001125 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1171373001126 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1171373001127 non-specific DNA binding site [nucleotide binding]; other site 1171373001128 salt bridge; other site 1171373001129 sequence-specific DNA binding site [nucleotide binding]; other site 1171373001130 Domain of unknown function (DUF955); Region: DUF955; cl01076 1171373001131 TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; pfam09370 1171373001132 hypothetical protein; Provisional; Region: PRK02399 1171373001133 Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792 1171373001134 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1171373001135 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1171373001136 DNA-binding site [nucleotide binding]; DNA binding site 1171373001137 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1171373001138 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1171373001139 homodimer interface [polypeptide binding]; other site 1171373001140 catalytic residue [active] 1171373001141 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1171373001142 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1171373001143 NAD(P) binding site [chemical binding]; other site 1171373001144 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1171373001145 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1171373001146 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1171373001147 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1171373001148 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1171373001149 DNA binding site [nucleotide binding] 1171373001150 domain linker motif; other site 1171373001151 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1171373001152 dimerization interface [polypeptide binding]; other site 1171373001153 ligand binding site [chemical binding]; other site 1171373001154 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1171373001155 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1171373001156 recombination factor protein RarA; Reviewed; Region: PRK13342 1171373001157 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1171373001158 Walker A motif; other site 1171373001159 ATP binding site [chemical binding]; other site 1171373001160 Walker B motif; other site 1171373001161 arginine finger; other site 1171373001162 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1171373001163 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1171373001164 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 1171373001165 active site 1171373001166 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1171373001167 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1171373001168 active site 1171373001169 catalytic site [active] 1171373001170 substrate binding site [chemical binding]; other site 1171373001171 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1171373001172 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1171373001173 Walker A/P-loop; other site 1171373001174 ATP binding site [chemical binding]; other site 1171373001175 Q-loop/lid; other site 1171373001176 ABC transporter signature motif; other site 1171373001177 Walker B; other site 1171373001178 D-loop; other site 1171373001179 H-loop/switch region; other site 1171373001180 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 1171373001181 hypothetical protein; Provisional; Region: PRK07906 1171373001182 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 1171373001183 putative metal binding site [ion binding]; other site 1171373001184 Right handed beta helix region; Region: Beta_helix; pfam13229 1171373001185 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1171373001186 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1171373001187 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1171373001188 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 1171373001189 inhibitor binding site; inhibition site 1171373001190 catalytic Zn binding site [ion binding]; other site 1171373001191 structural Zn binding site [ion binding]; other site 1171373001192 NADP binding site [chemical binding]; other site 1171373001193 tetramer interface [polypeptide binding]; other site 1171373001194 thymidine phosphorylase; Provisional; Region: PRK04350 1171373001195 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 1171373001196 transketolase; Reviewed; Region: PRK05899 1171373001197 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1171373001198 TPP-binding site [chemical binding]; other site 1171373001199 dimer interface [polypeptide binding]; other site 1171373001200 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1171373001201 PYR/PP interface [polypeptide binding]; other site 1171373001202 dimer interface [polypeptide binding]; other site 1171373001203 TPP binding site [chemical binding]; other site 1171373001204 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1171373001205 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1171373001206 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1171373001207 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 1171373001208 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1171373001209 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1171373001210 Coenzyme A binding pocket [chemical binding]; other site 1171373001211 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1171373001212 Domain of unknown function DUF21; Region: DUF21; pfam01595 1171373001213 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1171373001214 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1171373001215 Domain of unknown function DUF21; Region: DUF21; pfam01595 1171373001216 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1171373001217 Transporter associated domain; Region: CorC_HlyC; smart01091 1171373001218 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1171373001219 MOSC domain; Region: MOSC; pfam03473 1171373001220 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1171373001221 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1171373001222 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1171373001223 active site 1171373001224 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1171373001225 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1171373001226 active site 1171373001227 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 1171373001228 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1171373001229 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1171373001230 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1171373001231 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1171373001232 active site 1171373001233 substrate binding site [chemical binding]; other site 1171373001234 ATP binding site [chemical binding]; other site 1171373001235 Phosphotransferase enzyme family; Region: APH; pfam01636 1171373001236 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1171373001237 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1171373001238 active site 1171373001239 Uncharacterized protein conserved in bacteria (DUF2255); Region: DUF2255; pfam10012 1171373001240 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1171373001241 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1171373001242 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1171373001243 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1171373001244 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1171373001245 EamA-like transporter family; Region: EamA; pfam00892 1171373001246 Transglycosylase; Region: Transgly; pfam00912 1171373001247 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1171373001248 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1171373001249 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1171373001250 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1171373001251 Ligand binding site; other site 1171373001252 Putative Catalytic site; other site 1171373001253 DXD motif; other site 1171373001254 Predicted integral membrane protein [Function unknown]; Region: COG5542 1171373001255 Predicted membrane protein [Function unknown]; Region: COG2246 1171373001256 GtrA-like protein; Region: GtrA; pfam04138 1171373001257 colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427 1171373001258 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1171373001259 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1171373001260 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1171373001261 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1171373001262 Chain length determinant protein; Region: Wzz; cl15801 1171373001263 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1171373001264 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1171373001265 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 1171373001266 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1171373001267 putative CoA binding site [chemical binding]; other site 1171373001268 putative trimer interface [polypeptide binding]; other site 1171373001269 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 1171373001270 putative trimer interface [polypeptide binding]; other site 1171373001271 putative active site [active] 1171373001272 putative substrate binding site [chemical binding]; other site 1171373001273 putative CoA binding site [chemical binding]; other site 1171373001274 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1171373001275 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1171373001276 inhibitor-cofactor binding pocket; inhibition site 1171373001277 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1171373001278 catalytic residue [active] 1171373001279 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1171373001280 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1171373001281 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1171373001282 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1171373001283 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1171373001284 dimerization domain swap beta strand [polypeptide binding]; other site 1171373001285 regulatory protein interface [polypeptide binding]; other site 1171373001286 active site 1171373001287 regulatory phosphorylation site [posttranslational modification]; other site 1171373001288 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 1171373001289 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1171373001290 active site 1171373001291 phosphorylation site [posttranslational modification] 1171373001292 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1171373001293 active site 1171373001294 P-loop; other site 1171373001295 phosphorylation site [posttranslational modification] 1171373001296 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1171373001297 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1171373001298 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1171373001299 putative substrate binding site [chemical binding]; other site 1171373001300 putative ATP binding site [chemical binding]; other site 1171373001301 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1171373001302 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1171373001303 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1171373001304 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1171373001305 dimer interface [polypeptide binding]; other site 1171373001306 conserved gate region; other site 1171373001307 putative PBP binding loops; other site 1171373001308 ABC-ATPase subunit interface; other site 1171373001309 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1171373001310 dimer interface [polypeptide binding]; other site 1171373001311 conserved gate region; other site 1171373001312 putative PBP binding loops; other site 1171373001313 ABC-ATPase subunit interface; other site 1171373001314 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1171373001315 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1171373001316 substrate binding pocket [chemical binding]; other site 1171373001317 membrane-bound complex binding site; other site 1171373001318 hinge residues; other site 1171373001319 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1171373001320 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1171373001321 Walker A/P-loop; other site 1171373001322 ATP binding site [chemical binding]; other site 1171373001323 Q-loop/lid; other site 1171373001324 ABC transporter signature motif; other site 1171373001325 Walker B; other site 1171373001326 D-loop; other site 1171373001327 H-loop/switch region; other site 1171373001328 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 1171373001329 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1171373001330 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1171373001331 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1171373001332 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1171373001333 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1171373001334 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1171373001335 active site 1171373001336 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 1171373001337 homodimer interface [polypeptide binding]; other site 1171373001338 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1171373001339 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1171373001340 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1171373001341 active site residue [active] 1171373001342 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1171373001343 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1171373001344 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1171373001345 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 1171373001346 nudix motif; other site 1171373001347 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 1171373001348 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1171373001349 ATP binding site [chemical binding]; other site 1171373001350 putative Mg++ binding site [ion binding]; other site 1171373001351 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1171373001352 nucleotide binding region [chemical binding]; other site 1171373001353 ATP-binding site [chemical binding]; other site 1171373001354 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 1171373001355 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 1171373001356 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 1171373001357 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1171373001358 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1171373001359 active site 1171373001360 DNA binding site [nucleotide binding] 1171373001361 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 1171373001362 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1171373001363 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1171373001364 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 1171373001365 NAD(P) binding site [chemical binding]; other site 1171373001366 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1171373001367 MarR family; Region: MarR; pfam01047 1171373001368 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1171373001369 catalytic residues [active] 1171373001370 dimer interface [polypeptide binding]; other site 1171373001371 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1171373001372 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1171373001373 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1171373001374 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1171373001375 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1171373001376 catalytic residues [active] 1171373001377 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 1171373001378 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1171373001379 replicative DNA helicase; Region: DnaB; TIGR00665 1171373001380 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1171373001381 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1171373001382 Walker A motif; other site 1171373001383 ATP binding site [chemical binding]; other site 1171373001384 Walker B motif; other site 1171373001385 DNA binding loops [nucleotide binding] 1171373001386 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 1171373001387 putative homodimer interface [polypeptide binding]; other site 1171373001388 putative homotetramer interface [polypeptide binding]; other site 1171373001389 putative allosteric switch controlling residues; other site 1171373001390 putative metal binding site [ion binding]; other site 1171373001391 putative homodimer-homodimer interface [polypeptide binding]; other site 1171373001392 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1171373001393 metal-binding site [ion binding] 1171373001394 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1171373001395 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1171373001396 metal-binding site [ion binding] 1171373001397 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1171373001398 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1171373001399 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1171373001400 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1171373001401 G5 domain; Region: G5; pfam07501 1171373001402 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1171373001403 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 1171373001404 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565 1171373001405 Dihydroorotate dehydrogenase (DHOD) like proteins. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_like; cd04739 1171373001406 putative active site [active] 1171373001407 putative FMN binding site [chemical binding]; other site 1171373001408 putative substrate binding site [chemical binding]; other site 1171373001409 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 1171373001410 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1171373001411 dimer interface [polypeptide binding]; other site 1171373001412 PYR/PP interface [polypeptide binding]; other site 1171373001413 TPP binding site [chemical binding]; other site 1171373001414 substrate binding site [chemical binding]; other site 1171373001415 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1171373001416 Domain of unknown function; Region: EKR; pfam10371 1171373001417 4Fe-4S binding domain; Region: Fer4_6; pfam12837 1171373001418 4Fe-4S binding domain; Region: Fer4; pfam00037 1171373001419 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 1171373001420 TPP-binding site [chemical binding]; other site 1171373001421 dimer interface [polypeptide binding]; other site 1171373001422 putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771 1171373001423 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1171373001424 4Fe-4S binding domain; Region: Fer4; pfam00037 1171373001425 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1171373001426 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1171373001427 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1171373001428 DNA-binding site [nucleotide binding]; DNA binding site 1171373001429 FCD domain; Region: FCD; pfam07729 1171373001430 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 1171373001431 L-lactate permease; Region: Lactate_perm; cl00701 1171373001432 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1171373001433 Cysteine-rich domain; Region: CCG; pfam02754 1171373001434 Cysteine-rich domain; Region: CCG; pfam02754 1171373001435 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 1171373001436 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1171373001437 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 1171373001438 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 1171373001439 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1171373001440 Walker A/P-loop; other site 1171373001441 ATP binding site [chemical binding]; other site 1171373001442 Q-loop/lid; other site 1171373001443 ABC transporter signature motif; other site 1171373001444 Walker B; other site 1171373001445 D-loop; other site 1171373001446 H-loop/switch region; other site 1171373001447 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 1171373001448 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1171373001449 Walker A/P-loop; other site 1171373001450 ATP binding site [chemical binding]; other site 1171373001451 Q-loop/lid; other site 1171373001452 ABC transporter signature motif; other site 1171373001453 Walker B; other site 1171373001454 D-loop; other site 1171373001455 H-loop/switch region; other site 1171373001456 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1171373001457 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1171373001458 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1171373001459 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1171373001460 Penicillinase repressor; Region: Pencillinase_R; pfam03965 1171373001461 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1171373001462 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1171373001463 DNA binding residues [nucleotide binding] 1171373001464 dimerization interface [polypeptide binding]; other site 1171373001465 Flavin Reductases; Region: FlaRed; cl00801 1171373001466 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1171373001467 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH2; cd08183 1171373001468 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1171373001469 putative active site [active] 1171373001470 metal binding site [ion binding]; metal-binding site 1171373001471 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 1171373001472 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1171373001473 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1171373001474 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1171373001475 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1171373001476 putative PBP binding loops; other site 1171373001477 ABC-ATPase subunit interface; other site 1171373001478 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1171373001479 dimer interface [polypeptide binding]; other site 1171373001480 conserved gate region; other site 1171373001481 ABC-ATPase subunit interface; other site 1171373001482 Integrase core domain; Region: rve; pfam00665 1171373001483 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1171373001484 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1171373001485 DNA binding site [nucleotide binding] 1171373001486 domain linker motif; other site 1171373001487 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 1171373001488 ligand binding site [chemical binding]; other site 1171373001489 dimerization interface (open form) [polypeptide binding]; other site 1171373001490 dimerization interface (closed form) [polypeptide binding]; other site 1171373001491 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1171373001492 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1171373001493 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1171373001494 Walker A/P-loop; other site 1171373001495 ATP binding site [chemical binding]; other site 1171373001496 Q-loop/lid; other site 1171373001497 ABC transporter signature motif; other site 1171373001498 Walker B; other site 1171373001499 D-loop; other site 1171373001500 H-loop/switch region; other site 1171373001501 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1171373001502 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1171373001503 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1171373001504 Walker A/P-loop; other site 1171373001505 ATP binding site [chemical binding]; other site 1171373001506 Q-loop/lid; other site 1171373001507 ABC transporter signature motif; other site 1171373001508 Walker B; other site 1171373001509 D-loop; other site 1171373001510 H-loop/switch region; other site 1171373001511 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1171373001512 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1171373001513 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 1171373001514 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1171373001515 motif I; other site 1171373001516 active site 1171373001517 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 1171373001518 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1171373001519 putative substrate binding site [chemical binding]; other site 1171373001520 nucleotide binding site [chemical binding]; other site 1171373001521 nucleotide binding site [chemical binding]; other site 1171373001522 homodimer interface [polypeptide binding]; other site 1171373001523 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 1171373001524 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 1171373001525 membrane protein FdrA; Validated; Region: PRK06091 1171373001526 CoA binding domain; Region: CoA_binding; cl17356 1171373001527 CoA-ligase; Region: Ligase_CoA; pfam00549 1171373001528 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1171373001529 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1171373001530 DNA-binding site [nucleotide binding]; DNA binding site 1171373001531 FCD domain; Region: FCD; pfam07729 1171373001532 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1171373001533 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1171373001534 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1171373001535 allantoate amidohydrolase; Reviewed; Region: PRK09290 1171373001536 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1171373001537 active site 1171373001538 metal binding site [ion binding]; metal-binding site 1171373001539 dimer interface [polypeptide binding]; other site 1171373001540 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 1171373001541 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1171373001542 catalytic residue [active] 1171373001543 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1171373001544 allantoinase; Region: allantoinase; TIGR03178 1171373001545 active site 1171373001546 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 1171373001547 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1171373001548 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 1171373001549 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1171373001550 Na binding site [ion binding]; other site 1171373001551 putative substrate binding site [chemical binding]; other site 1171373001552 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1171373001553 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 1171373001554 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1171373001555 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1171373001556 dimer interface [polypeptide binding]; other site 1171373001557 putative anticodon binding site; other site 1171373001558 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1171373001559 motif 1; other site 1171373001560 dimer interface [polypeptide binding]; other site 1171373001561 active site 1171373001562 motif 2; other site 1171373001563 motif 3; other site 1171373001564 Uncharacterized protein family (UPF0233); Region: UPF0233; cl11506 1171373001565 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 1171373001566 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1171373001567 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1171373001568 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1171373001569 glutamine binding [chemical binding]; other site 1171373001570 catalytic triad [active] 1171373001571 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1171373001572 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1171373001573 active site 1171373001574 ATP binding site [chemical binding]; other site 1171373001575 substrate binding site [chemical binding]; other site 1171373001576 activation loop (A-loop); other site 1171373001577 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1171373001578 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1171373001579 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1171373001580 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1171373001581 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1171373001582 active site 1171373001583 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1171373001584 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1171373001585 phosphopeptide binding site; other site 1171373001586 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 1171373001587 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1171373001588 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1171373001589 phosphopeptide binding site; other site 1171373001590 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 1171373001591 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 1171373001592 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1171373001593 NADP binding site [chemical binding]; other site 1171373001594 active site 1171373001595 putative substrate binding site [chemical binding]; other site 1171373001596 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1171373001597 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1171373001598 NAD binding site [chemical binding]; other site 1171373001599 substrate binding site [chemical binding]; other site 1171373001600 homodimer interface [polypeptide binding]; other site 1171373001601 active site 1171373001602 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1171373001603 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1171373001604 substrate binding site; other site 1171373001605 tetramer interface; other site 1171373001606 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1171373001607 Excalibur calcium-binding domain; Region: Excalibur; smart00894 1171373001608 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 1171373001609 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 1171373001610 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1171373001611 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1171373001612 putative NAD(P) binding site [chemical binding]; other site 1171373001613 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1171373001614 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1171373001615 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1171373001616 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1171373001617 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1171373001618 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 1171373001619 VanZ like family; Region: VanZ; cl01971 1171373001620 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 1171373001621 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 1171373001622 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 1171373001623 catalytic site [active] 1171373001624 active site 1171373001625 YcfA-like protein; Region: YcfA; pfam07927 1171373001626 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 1171373001627 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 1171373001628 active site 1171373001629 catalytic site [active] 1171373001630 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1171373001631 metabolite-proton symporter; Region: 2A0106; TIGR00883 1171373001632 putative substrate translocation pore; other site 1171373001633 Predicted transcriptional regulators [Transcription]; Region: COG1695 1171373001634 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1171373001635 putative DNA binding site [nucleotide binding]; other site 1171373001636 putative Zn2+ binding site [ion binding]; other site 1171373001637 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1171373001638 ABC1 family; Region: ABC1; cl17513 1171373001639 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1171373001640 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1171373001641 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1171373001642 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1171373001643 Walker A/P-loop; other site 1171373001644 ATP binding site [chemical binding]; other site 1171373001645 Q-loop/lid; other site 1171373001646 ABC transporter signature motif; other site 1171373001647 Walker B; other site 1171373001648 D-loop; other site 1171373001649 H-loop/switch region; other site 1171373001650 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 1171373001651 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1171373001652 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1171373001653 endonuclease III; Region: ENDO3c; smart00478 1171373001654 minor groove reading motif; other site 1171373001655 helix-hairpin-helix signature motif; other site 1171373001656 substrate binding pocket [chemical binding]; other site 1171373001657 active site 1171373001658 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1171373001659 RNA binding surface [nucleotide binding]; other site 1171373001660 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 1171373001661 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1171373001662 Walker A motif; other site 1171373001663 ATP binding site [chemical binding]; other site 1171373001664 Walker B motif; other site 1171373001665 arginine finger; other site 1171373001666 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1171373001667 hypothetical protein; Validated; Region: PRK00153 1171373001668 recombination protein RecR; Reviewed; Region: recR; PRK00076 1171373001669 RecR protein; Region: RecR; pfam02132 1171373001670 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1171373001671 putative active site [active] 1171373001672 putative metal-binding site [ion binding]; other site 1171373001673 tetramer interface [polypeptide binding]; other site 1171373001674 Domain of unknown function DUF77; Region: DUF77; pfam01910 1171373001675 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1171373001676 putative substrate translocation pore; other site 1171373001677 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1171373001678 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 1171373001679 Predicted transcriptional regulators [Transcription]; Region: COG1695 1171373001680 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1171373001681 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1171373001682 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1171373001683 Walker A/P-loop; other site 1171373001684 ATP binding site [chemical binding]; other site 1171373001685 Q-loop/lid; other site 1171373001686 ABC transporter signature motif; other site 1171373001687 Walker B; other site 1171373001688 D-loop; other site 1171373001689 H-loop/switch region; other site 1171373001690 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1171373001691 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1171373001692 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1171373001693 Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060 1171373001694 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1171373001695 active site 1171373001696 HIGH motif; other site 1171373001697 nucleotide binding site [chemical binding]; other site 1171373001698 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1171373001699 active site 1171373001700 KMSKS motif; other site 1171373001701 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 1171373001702 tRNA binding surface [nucleotide binding]; other site 1171373001703 anticodon binding site; other site 1171373001704 Predicted acetyltransferase [General function prediction only]; Region: COG2388 1171373001705 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1171373001706 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1171373001707 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1171373001708 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1171373001709 aspartate kinase; Reviewed; Region: PRK06635 1171373001710 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1171373001711 putative nucleotide binding site [chemical binding]; other site 1171373001712 putative catalytic residues [active] 1171373001713 putative Mg ion binding site [ion binding]; other site 1171373001714 putative aspartate binding site [chemical binding]; other site 1171373001715 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1171373001716 putative allosteric regulatory site; other site 1171373001717 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1171373001718 putative allosteric regulatory residue; other site 1171373001719 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1171373001720 Integrase core domain; Region: rve; pfam00665 1171373001721 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1171373001722 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1171373001723 Integral membrane protein TerC family; Region: TerC; cl10468 1171373001724 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1171373001725 putative substrate translocation pore; other site 1171373001726 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1171373001727 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1171373001728 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 1171373001729 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1171373001730 dimerization interface [polypeptide binding]; other site 1171373001731 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1171373001732 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1171373001733 transmembrane helices; other site 1171373001734 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1171373001735 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1171373001736 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1171373001737 Ligand Binding Site [chemical binding]; other site 1171373001738 CrcB-like protein; Region: CRCB; pfam02537 1171373001739 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 1171373001740 CHAP domain; Region: CHAP; pfam05257 1171373001741 Surface antigen [General function prediction only]; Region: COG3942 1171373001742 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1171373001743 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1171373001744 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1171373001745 active site 1171373001746 catalytic tetrad [active] 1171373001747 Cutinase; Region: Cutinase; pfam01083 1171373001748 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1171373001749 substrate binding site [chemical binding]; other site 1171373001750 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 1171373001751 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1171373001752 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1171373001753 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1171373001754 ATP binding site [chemical binding]; other site 1171373001755 putative Mg++ binding site [ion binding]; other site 1171373001756 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1171373001757 nucleotide binding region [chemical binding]; other site 1171373001758 ATP-binding site [chemical binding]; other site 1171373001759 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 1171373001760 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1171373001761 active site 1171373001762 intersubunit interface [polypeptide binding]; other site 1171373001763 catalytic residue [active] 1171373001764 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1171373001765 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1171373001766 active site 1171373001767 dimer interface [polypeptide binding]; other site 1171373001768 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1171373001769 dimer interface [polypeptide binding]; other site 1171373001770 active site 1171373001771 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1171373001772 putative active site [active] 1171373001773 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1171373001774 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1171373001775 polyol permease family; Region: 2A0118; TIGR00897 1171373001776 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1171373001777 putative substrate translocation pore; other site 1171373001778 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1171373001779 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1171373001780 active site 1171373001781 catalytic tetrad [active] 1171373001782 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1171373001783 arginine-tRNA ligase; Region: PLN02286 1171373001784 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1171373001785 active site 1171373001786 HIGH motif; other site 1171373001787 KMSK motif region; other site 1171373001788 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1171373001789 tRNA binding surface [nucleotide binding]; other site 1171373001790 anticodon binding site; other site 1171373001791 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1171373001792 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1171373001793 nucleotide binding site [chemical binding]; other site 1171373001794 Predicted membrane protein [Function unknown]; Region: COG3428 1171373001795 Bacterial PH domain; Region: DUF304; pfam03703 1171373001796 Bacterial PH domain; Region: DUF304; pfam03703 1171373001797 Bacterial PH domain; Region: DUF304; cl01348 1171373001798 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1171373001799 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1171373001800 putative substrate translocation pore; other site 1171373001801 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1171373001802 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1171373001803 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 1171373001804 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 1171373001805 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1171373001806 NAD binding site [chemical binding]; other site 1171373001807 catalytic residues [active] 1171373001808 substrate binding site [chemical binding]; other site 1171373001809 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 1171373001810 active site 1171373001811 Zn2+ binding site [ion binding]; other site 1171373001812 intersubunit interface [polypeptide binding]; other site 1171373001813 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 1171373001814 N- and C-terminal domain interface [polypeptide binding]; other site 1171373001815 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 1171373001816 active site 1171373001817 putative catalytic site [active] 1171373001818 metal binding site [ion binding]; metal-binding site 1171373001819 ATP binding site [chemical binding]; other site 1171373001820 carbohydrate binding site [chemical binding]; other site 1171373001821 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 1171373001822 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1171373001823 putative substrate translocation pore; other site 1171373001824 Domain of unknown function (DUF718); Region: DUF718; cl01281 1171373001825 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1171373001826 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1171373001827 DNA binding site [nucleotide binding] 1171373001828 domain linker motif; other site 1171373001829 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1171373001830 dimerization interface [polypeptide binding]; other site 1171373001831 ligand binding site [chemical binding]; other site 1171373001832 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 1171373001833 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1171373001834 putative NAD(P) binding site [chemical binding]; other site 1171373001835 homodimer interface [polypeptide binding]; other site 1171373001836 Predicted permeases [General function prediction only]; Region: COG0679 1171373001837 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1171373001838 putative substrate translocation pore; other site 1171373001839 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1171373001840 Predicted transcriptional regulators [Transcription]; Region: COG1725 1171373001841 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1171373001842 DNA-binding site [nucleotide binding]; DNA binding site 1171373001843 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1171373001844 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1171373001845 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1171373001846 DNA binding site [nucleotide binding] 1171373001847 domain linker motif; other site 1171373001848 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1171373001849 dimerization interface [polypeptide binding]; other site 1171373001850 ligand binding site [chemical binding]; other site 1171373001851 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1171373001852 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1171373001853 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1171373001854 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1171373001855 dimer interface [polypeptide binding]; other site 1171373001856 conserved gate region; other site 1171373001857 putative PBP binding loops; other site 1171373001858 ABC-ATPase subunit interface; other site 1171373001859 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1171373001860 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1171373001861 dimer interface [polypeptide binding]; other site 1171373001862 conserved gate region; other site 1171373001863 ABC-ATPase subunit interface; other site 1171373001864 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1171373001865 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1171373001866 Walker A/P-loop; other site 1171373001867 ATP binding site [chemical binding]; other site 1171373001868 Q-loop/lid; other site 1171373001869 ABC transporter signature motif; other site 1171373001870 Walker B; other site 1171373001871 D-loop; other site 1171373001872 H-loop/switch region; other site 1171373001873 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1171373001874 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1171373001875 Walker A/P-loop; other site 1171373001876 ATP binding site [chemical binding]; other site 1171373001877 Q-loop/lid; other site 1171373001878 ABC transporter signature motif; other site 1171373001879 Walker B; other site 1171373001880 D-loop; other site 1171373001881 H-loop/switch region; other site 1171373001882 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1171373001883 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1171373001884 Aspartase; Region: Aspartase; cd01357 1171373001885 active sites [active] 1171373001886 tetramer interface [polypeptide binding]; other site 1171373001887 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 1171373001888 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822 1171373001889 putative NAD(P) binding site [chemical binding]; other site 1171373001890 putative substrate binding site [chemical binding]; other site 1171373001891 catalytic Zn binding site [ion binding]; other site 1171373001892 structural Zn binding site [ion binding]; other site 1171373001893 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK06476 1171373001894 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1171373001895 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 1171373001896 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 1171373001897 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1171373001898 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1171373001899 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1171373001900 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1171373001901 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1171373001902 Amidase; Region: Amidase; cl11426 1171373001903 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1171373001904 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1171373001905 Walker A/P-loop; other site 1171373001906 ATP binding site [chemical binding]; other site 1171373001907 Q-loop/lid; other site 1171373001908 ABC transporter signature motif; other site 1171373001909 Walker B; other site 1171373001910 D-loop; other site 1171373001911 H-loop/switch region; other site 1171373001912 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1171373001913 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1171373001914 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1171373001915 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1171373001916 Walker A/P-loop; other site 1171373001917 ATP binding site [chemical binding]; other site 1171373001918 Q-loop/lid; other site 1171373001919 ABC transporter signature motif; other site 1171373001920 Walker B; other site 1171373001921 D-loop; other site 1171373001922 H-loop/switch region; other site 1171373001923 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1171373001924 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1171373001925 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1171373001926 putative DNA binding site [nucleotide binding]; other site 1171373001927 putative Zn2+ binding site [ion binding]; other site 1171373001928 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1171373001929 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1171373001930 nucleotide binding site [chemical binding]; other site 1171373001931 Melibiase; Region: Melibiase; pfam02065 1171373001932 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1171373001933 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1171373001934 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1171373001935 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1171373001936 dimer interface [polypeptide binding]; other site 1171373001937 conserved gate region; other site 1171373001938 putative PBP binding loops; other site 1171373001939 ABC-ATPase subunit interface; other site 1171373001940 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1171373001941 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1171373001942 dimer interface [polypeptide binding]; other site 1171373001943 conserved gate region; other site 1171373001944 putative PBP binding loops; other site 1171373001945 ABC-ATPase subunit interface; other site 1171373001946 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1171373001947 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1171373001948 motif II; other site 1171373001949 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 1171373001950 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 1171373001951 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1171373001952 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 1171373001953 active site 1171373001954 catalytic residues [active] 1171373001955 phosphoserine phosphatase SerB; Region: serB; TIGR00338 1171373001956 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1171373001957 motif II; other site 1171373001958 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 1171373001959 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1171373001960 S-adenosylmethionine binding site [chemical binding]; other site 1171373001961 PEP synthetase regulatory protein; Provisional; Region: PRK05339 1171373001962 pyruvate phosphate dikinase; Provisional; Region: PRK09279 1171373001963 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1171373001964 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1171373001965 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1171373001966 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1171373001967 phosphopeptide binding site; other site 1171373001968 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1171373001969 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1171373001970 intersubunit interface [polypeptide binding]; other site 1171373001971 active site 1171373001972 catalytic residue [active] 1171373001973 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1171373001974 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1171373001975 dimerization interface [polypeptide binding]; other site 1171373001976 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1171373001977 dimer interface [polypeptide binding]; other site 1171373001978 phosphorylation site [posttranslational modification] 1171373001979 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1171373001980 ATP binding site [chemical binding]; other site 1171373001981 Mg2+ binding site [ion binding]; other site 1171373001982 G-X-G motif; other site 1171373001983 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1171373001984 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1171373001985 active site 1171373001986 phosphorylation site [posttranslational modification] 1171373001987 intermolecular recognition site; other site 1171373001988 dimerization interface [polypeptide binding]; other site 1171373001989 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1171373001990 DNA binding site [nucleotide binding] 1171373001991 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1171373001992 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1171373001993 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1171373001994 nucleotide binding site [chemical binding]; other site 1171373001995 NEF interaction site [polypeptide binding]; other site 1171373001996 SBD interface [polypeptide binding]; other site 1171373001997 GrpE; Region: GrpE; pfam01025 1171373001998 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1171373001999 dimer interface [polypeptide binding]; other site 1171373002000 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1171373002001 chaperone protein DnaJ; Provisional; Region: PRK14295 1171373002002 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1171373002003 HSP70 interaction site [polypeptide binding]; other site 1171373002004 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1171373002005 Zn binding sites [ion binding]; other site 1171373002006 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1171373002007 dimer interface [polypeptide binding]; other site 1171373002008 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1171373002009 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1171373002010 DNA binding residues [nucleotide binding] 1171373002011 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1171373002012 6-hydroxycyclohex-1-ene-1-carboxyl-CoA dehydrogenase, N-benzyl-3-pyrrolidinol dehydrogenase, and other MDR family members; Region: hydroxyacyl_CoA_DH; cd08254 1171373002013 putative NAD(P) binding site [chemical binding]; other site 1171373002014 catalytic Zn binding site [ion binding]; other site 1171373002015 structural Zn binding site [ion binding]; other site 1171373002016 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 1171373002017 Predicted permease [General function prediction only]; Region: COG2985 1171373002018 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 1171373002019 TrkA-C domain; Region: TrkA_C; pfam02080 1171373002020 TrkA-C domain; Region: TrkA_C; pfam02080 1171373002021 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 1171373002022 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1171373002023 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 1171373002024 nudix motif; other site 1171373002025 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1171373002026 FtsX-like permease family; Region: FtsX; pfam02687 1171373002027 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1171373002028 FtsX-like permease family; Region: FtsX; pfam02687 1171373002029 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1171373002030 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1171373002031 Walker A/P-loop; other site 1171373002032 ATP binding site [chemical binding]; other site 1171373002033 Q-loop/lid; other site 1171373002034 ABC transporter signature motif; other site 1171373002035 Walker B; other site 1171373002036 D-loop; other site 1171373002037 H-loop/switch region; other site 1171373002038 VanZ like family; Region: VanZ; pfam04892 1171373002039 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1171373002040 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1171373002041 active site 1171373002042 phosphorylation site [posttranslational modification] 1171373002043 intermolecular recognition site; other site 1171373002044 dimerization interface [polypeptide binding]; other site 1171373002045 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1171373002046 DNA binding residues [nucleotide binding] 1171373002047 dimerization interface [polypeptide binding]; other site 1171373002048 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1171373002049 Histidine kinase; Region: HisKA_3; pfam07730 1171373002050 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1171373002051 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 1171373002052 fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377 1171373002053 catalytic residue [active] 1171373002054 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1171373002055 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1171373002056 DNA binding site [nucleotide binding] 1171373002057 domain linker motif; other site 1171373002058 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1171373002059 dimerization interface [polypeptide binding]; other site 1171373002060 ligand binding site [chemical binding]; other site 1171373002061 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 1171373002062 Melibiase; Region: Melibiase; pfam02065 1171373002063 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1171373002064 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1171373002065 Eukaryotic phosphomannomutase; Region: PMM; cl17107 1171373002066 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 1171373002067 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1171373002068 dimer interface [polypeptide binding]; other site 1171373002069 conserved gate region; other site 1171373002070 putative PBP binding loops; other site 1171373002071 ABC-ATPase subunit interface; other site 1171373002072 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1171373002073 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1171373002074 dimer interface [polypeptide binding]; other site 1171373002075 conserved gate region; other site 1171373002076 putative PBP binding loops; other site 1171373002077 ABC-ATPase subunit interface; other site 1171373002078 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1171373002079 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1171373002080 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1171373002081 Clp amino terminal domain; Region: Clp_N; pfam02861 1171373002082 Clp amino terminal domain; Region: Clp_N; pfam02861 1171373002083 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1171373002084 Walker A motif; other site 1171373002085 ATP binding site [chemical binding]; other site 1171373002086 Walker B motif; other site 1171373002087 arginine finger; other site 1171373002088 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1171373002089 Walker A motif; other site 1171373002090 ATP binding site [chemical binding]; other site 1171373002091 Walker B motif; other site 1171373002092 arginine finger; other site 1171373002093 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1171373002094 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1171373002095 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1171373002096 dimer interface [polypeptide binding]; other site 1171373002097 conserved gate region; other site 1171373002098 putative PBP binding loops; other site 1171373002099 ABC-ATPase subunit interface; other site 1171373002100 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1171373002101 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1171373002102 dimer interface [polypeptide binding]; other site 1171373002103 conserved gate region; other site 1171373002104 putative PBP binding loops; other site 1171373002105 ABC-ATPase subunit interface; other site 1171373002106 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1171373002107 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1171373002108 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1171373002109 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1171373002110 substrate binding site [chemical binding]; other site 1171373002111 ATP binding site [chemical binding]; other site 1171373002112 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1171373002113 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1171373002114 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1171373002115 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 1171373002116 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1171373002117 NAD binding site [chemical binding]; other site 1171373002118 sugar binding site [chemical binding]; other site 1171373002119 divalent metal binding site [ion binding]; other site 1171373002120 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1171373002121 dimer interface [polypeptide binding]; other site 1171373002122 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1171373002123 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1171373002124 putative active site [active] 1171373002125 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1171373002126 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1171373002127 putative dimer interface [polypeptide binding]; other site 1171373002128 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1171373002129 Predicted membrane protein [Function unknown]; Region: COG1511 1171373002130 Predicted membrane protein [Function unknown]; Region: COG1511 1171373002131 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1171373002132 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1171373002133 Walker A/P-loop; other site 1171373002134 ATP binding site [chemical binding]; other site 1171373002135 Q-loop/lid; other site 1171373002136 ABC transporter signature motif; other site 1171373002137 Walker B; other site 1171373002138 D-loop; other site 1171373002139 H-loop/switch region; other site 1171373002140 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1171373002141 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1171373002142 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1171373002143 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1171373002144 NAD(P) binding site [chemical binding]; other site 1171373002145 active site 1171373002146 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1171373002147 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1171373002148 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 1171373002149 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1171373002150 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1171373002151 ATP binding site [chemical binding]; other site 1171373002152 putative Mg++ binding site [ion binding]; other site 1171373002153 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 1171373002154 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1171373002155 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1171373002156 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1171373002157 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1171373002158 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1171373002159 S-adenosylmethionine binding site [chemical binding]; other site 1171373002160 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1171373002161 hypothetical protein; Provisional; Region: PRK01842 1171373002162 SEC-C motif; Region: SEC-C; pfam02810 1171373002163 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 1171373002164 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1171373002165 Walker A/P-loop; other site 1171373002166 ATP binding site [chemical binding]; other site 1171373002167 Q-loop/lid; other site 1171373002168 ABC transporter signature motif; other site 1171373002169 Walker B; other site 1171373002170 D-loop; other site 1171373002171 H-loop/switch region; other site 1171373002172 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1171373002173 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 1171373002174 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1171373002175 dimer interface [polypeptide binding]; other site 1171373002176 conserved gate region; other site 1171373002177 ABC-ATPase subunit interface; other site 1171373002178 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1171373002179 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1171373002180 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1171373002181 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1171373002182 Predicted transcriptional regulators [Transcription]; Region: COG1725 1171373002183 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1171373002184 DNA-binding site [nucleotide binding]; DNA binding site 1171373002185 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1171373002186 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1171373002187 Walker A/P-loop; other site 1171373002188 ATP binding site [chemical binding]; other site 1171373002189 Q-loop/lid; other site 1171373002190 ABC transporter signature motif; other site 1171373002191 Walker B; other site 1171373002192 D-loop; other site 1171373002193 H-loop/switch region; other site 1171373002194 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1171373002195 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 1171373002196 dimer interface [polypeptide binding]; other site 1171373002197 conserved gate region; other site 1171373002198 ABC-ATPase subunit interface; other site 1171373002199 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1171373002200 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1171373002201 Walker A/P-loop; other site 1171373002202 ATP binding site [chemical binding]; other site 1171373002203 Q-loop/lid; other site 1171373002204 ABC transporter signature motif; other site 1171373002205 Walker B; other site 1171373002206 D-loop; other site 1171373002207 H-loop/switch region; other site 1171373002208 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1171373002209 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1171373002210 dimer interface [polypeptide binding]; other site 1171373002211 conserved gate region; other site 1171373002212 putative PBP binding loops; other site 1171373002213 ABC-ATPase subunit interface; other site 1171373002214 choline dehydrogenase; Validated; Region: PRK02106 1171373002215 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1171373002216 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1171373002217 glycine betaine aldehyde dehydrogenase; Region: BADH; TIGR01804 1171373002218 NAD(P) binding site [chemical binding]; other site 1171373002219 catalytic residues [active] 1171373002220 aspartate aminotransferase; Provisional; Region: PRK06348 1171373002221 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1171373002222 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1171373002223 homodimer interface [polypeptide binding]; other site 1171373002224 catalytic residue [active] 1171373002225 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1171373002226 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 1171373002227 active site 1171373002228 catalytic site [active] 1171373002229 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 1171373002230 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 1171373002231 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1171373002232 active site 1171373002233 nucleotide binding site [chemical binding]; other site 1171373002234 HIGH motif; other site 1171373002235 KMSKS motif; other site 1171373002236 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1171373002237 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1171373002238 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955 1171373002239 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1171373002240 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1171373002241 active site 1171373002242 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1171373002243 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1171373002244 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1171373002245 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1171373002246 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1171373002247 Right handed beta helix region; Region: Beta_helix; pfam13229 1171373002248 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 1171373002249 Chain length determinant protein; Region: Wzz; cl15801 1171373002250 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 1171373002251 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1171373002252 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1171373002253 PQQ-like domain; Region: PQQ_2; pfam13360 1171373002254 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1171373002255 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 1171373002256 FOG: PKD repeat [General function prediction only]; Region: COG3291 1171373002257 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 1171373002258 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 1171373002259 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 1171373002260 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1171373002261 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1171373002262 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1171373002263 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1171373002264 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 1171373002265 active site 1171373002266 intersubunit interface [polypeptide binding]; other site 1171373002267 zinc binding site [ion binding]; other site 1171373002268 Na+ binding site [ion binding]; other site 1171373002269 oxaloacetate decarboxylase; Provisional; Region: PRK12330 1171373002270 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1171373002271 active site 1171373002272 catalytic residues [active] 1171373002273 metal binding site [ion binding]; metal-binding site 1171373002274 homodimer binding site [polypeptide binding]; other site 1171373002275 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 1171373002276 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1171373002277 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1171373002278 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1171373002279 carboxyltransferase (CT) interaction site; other site 1171373002280 biotinylation site [posttranslational modification]; other site 1171373002281 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1171373002282 malonic semialdehyde reductase; Provisional; Region: PRK10538 1171373002283 NAD(P) binding site [chemical binding]; other site 1171373002284 active site 1171373002285 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1171373002286 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1171373002287 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1171373002288 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1171373002289 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1171373002290 dimerization domain swap beta strand [polypeptide binding]; other site 1171373002291 regulatory protein interface [polypeptide binding]; other site 1171373002292 active site 1171373002293 regulatory phosphorylation site [posttranslational modification]; other site 1171373002294 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1171373002295 catalytic core [active] 1171373002296 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 1171373002297 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1171373002298 PhoU domain; Region: PhoU; pfam01895 1171373002299 PhoU domain; Region: PhoU; pfam01895 1171373002300 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1171373002301 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1171373002302 dimer interface [polypeptide binding]; other site 1171373002303 phosphorylation site [posttranslational modification] 1171373002304 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1171373002305 ATP binding site [chemical binding]; other site 1171373002306 Mg2+ binding site [ion binding]; other site 1171373002307 G-X-G motif; other site 1171373002308 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1171373002309 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1171373002310 active site 1171373002311 phosphorylation site [posttranslational modification] 1171373002312 intermolecular recognition site; other site 1171373002313 dimerization interface [polypeptide binding]; other site 1171373002314 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1171373002315 DNA binding site [nucleotide binding] 1171373002316 Integrase core domain; Region: rve; pfam00665 1171373002317 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 1171373002318 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1171373002319 active site 1171373002320 phosphorylation site [posttranslational modification] 1171373002321 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 1171373002322 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 1171373002323 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 1171373002324 active site 1171373002325 P-loop; other site 1171373002326 phosphorylation site [posttranslational modification] 1171373002327 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GpsA; COG0240 1171373002328 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1171373002329 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1171373002330 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1171373002331 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 1171373002332 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1171373002333 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; cl01515 1171373002334 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 1171373002335 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 1171373002336 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 1171373002337 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; cl01516 1171373002338 Glucitol operon activator protein (GutM); Region: GutM; cl01890 1171373002339 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 1171373002340 SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616 1171373002341 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1171373002342 L-iditol 2-dehydrogenase; Region: iditol_2_DH_like; cd08235 1171373002343 putative NAD(P) binding site [chemical binding]; other site 1171373002344 catalytic Zn binding site [ion binding]; other site 1171373002345 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_10; cd12171 1171373002346 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1171373002347 putative ligand binding site [chemical binding]; other site 1171373002348 putative NAD binding site [chemical binding]; other site 1171373002349 catalytic site [active] 1171373002350 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1171373002351 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1171373002352 DNA binding residues [nucleotide binding] 1171373002353 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1171373002354 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1171373002355 intersubunit interface [polypeptide binding]; other site 1171373002356 active site 1171373002357 zinc binding site [ion binding]; other site 1171373002358 Na+ binding site [ion binding]; other site 1171373002359 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 1171373002360 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1171373002361 substrate binding site [chemical binding]; other site 1171373002362 dimer interface [polypeptide binding]; other site 1171373002363 catalytic triad [active] 1171373002364 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1171373002365 substrate binding site; other site 1171373002366 dimer interface; other site 1171373002367 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1171373002368 homotrimer interaction site [polypeptide binding]; other site 1171373002369 zinc binding site [ion binding]; other site 1171373002370 CDP-binding sites; other site 1171373002371 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1171373002372 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 1171373002373 serine hydroxymethyltransferase; Provisional; Region: PRK13580 1171373002374 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1171373002375 dimer interface [polypeptide binding]; other site 1171373002376 active site 1171373002377 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1171373002378 folate binding site [chemical binding]; other site 1171373002379 magnesium chelatase subunit H; Provisional; Region: bchH; PRK13405 1171373002380 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1171373002381 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1171373002382 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1171373002383 S-adenosylmethionine binding site [chemical binding]; other site 1171373002384 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1171373002385 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1171373002386 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1171373002387 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1171373002388 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1171373002389 active site 1171373002390 HIGH motif; other site 1171373002391 nucleotide binding site [chemical binding]; other site 1171373002392 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1171373002393 KMSKS motif; other site 1171373002394 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1171373002395 tRNA binding surface [nucleotide binding]; other site 1171373002396 anticodon binding site; other site 1171373002397 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 1171373002398 O-succinylhomoserine (thiol)-lyase; Region: O_succ_thio_ly; TIGR02080 1171373002399 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1171373002400 homodimer interface [polypeptide binding]; other site 1171373002401 substrate-cofactor binding pocket; other site 1171373002402 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1171373002403 catalytic residue [active] 1171373002404 Asp23 family; Region: Asp23; pfam03780 1171373002405 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1171373002406 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1171373002407 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1171373002408 Walker A/P-loop; other site 1171373002409 ATP binding site [chemical binding]; other site 1171373002410 Q-loop/lid; other site 1171373002411 ABC transporter signature motif; other site 1171373002412 Walker B; other site 1171373002413 D-loop; other site 1171373002414 H-loop/switch region; other site 1171373002415 TOBE domain; Region: TOBE_2; pfam08402 1171373002416 magnesium chelatase subunit H; Provisional; Region: bchH; PRK13405 1171373002417 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1171373002418 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1171373002419 putative substrate translocation pore; other site 1171373002420 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1171373002421 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 1171373002422 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1171373002423 motif II; other site 1171373002424 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1171373002425 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1171373002426 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1171373002427 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1171373002428 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1171373002429 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1171373002430 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1171373002431 nucleotide binding site [chemical binding]; other site 1171373002432 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1171373002433 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1171373002434 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1171373002435 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1171373002436 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1171373002437 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1171373002438 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1171373002439 dimer interface [polypeptide binding]; other site 1171373002440 conserved gate region; other site 1171373002441 putative PBP binding loops; other site 1171373002442 ABC-ATPase subunit interface; other site 1171373002443 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1171373002444 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1171373002445 dimer interface [polypeptide binding]; other site 1171373002446 conserved gate region; other site 1171373002447 ABC-ATPase subunit interface; other site 1171373002448 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 1171373002449 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1171373002450 NAD(P) binding site [chemical binding]; other site 1171373002451 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1171373002452 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1171373002453 substrate-cofactor binding pocket; other site 1171373002454 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1171373002455 catalytic residue [active] 1171373002456 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1171373002457 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1171373002458 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 1171373002459 ADP-ribose binding site [chemical binding]; other site 1171373002460 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1171373002461 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 1171373002462 Walker A/P-loop; other site 1171373002463 ATP binding site [chemical binding]; other site 1171373002464 Q-loop/lid; other site 1171373002465 ABC transporter signature motif; other site 1171373002466 Walker B; other site 1171373002467 D-loop; other site 1171373002468 H-loop/switch region; other site 1171373002469 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1171373002470 Histidine kinase; Region: HisKA_3; pfam07730 1171373002471 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 1171373002472 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1171373002473 active site 1171373002474 phosphorylation site [posttranslational modification] 1171373002475 intermolecular recognition site; other site 1171373002476 dimerization interface [polypeptide binding]; other site 1171373002477 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1171373002478 DNA binding residues [nucleotide binding] 1171373002479 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1171373002480 dihydropteroate synthase; Region: DHPS; TIGR01496 1171373002481 substrate binding pocket [chemical binding]; other site 1171373002482 dimer interface [polypeptide binding]; other site 1171373002483 inhibitor binding site; inhibition site 1171373002484 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1171373002485 catalytic core [active] 1171373002486 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1171373002487 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 1171373002488 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 1171373002489 Walker A/P-loop; other site 1171373002490 ATP binding site [chemical binding]; other site 1171373002491 Q-loop/lid; other site 1171373002492 ABC transporter signature motif; other site 1171373002493 Walker B; other site 1171373002494 D-loop; other site 1171373002495 H-loop/switch region; other site 1171373002496 Histidine kinase; Region: HisKA_3; pfam07730 1171373002497 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1171373002498 ATP binding site [chemical binding]; other site 1171373002499 Mg2+ binding site [ion binding]; other site 1171373002500 G-X-G motif; other site 1171373002501 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1171373002502 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1171373002503 active site 1171373002504 phosphorylation site [posttranslational modification] 1171373002505 intermolecular recognition site; other site 1171373002506 dimerization interface [polypeptide binding]; other site 1171373002507 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1171373002508 DNA binding residues [nucleotide binding] 1171373002509 dimerization interface [polypeptide binding]; other site 1171373002510 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 1171373002511 cobyric acid synthase; Provisional; Region: PRK00784 1171373002512 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1171373002513 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1171373002514 catalytic triad [active] 1171373002515 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 1171373002516 active site 1171373002517 SAM binding site [chemical binding]; other site 1171373002518 homodimer interface [polypeptide binding]; other site 1171373002519 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 1171373002520 active site 1171373002521 SAM binding site [chemical binding]; other site 1171373002522 homodimer interface [polypeptide binding]; other site 1171373002523 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 1171373002524 active site 1171373002525 SAM binding site [chemical binding]; other site 1171373002526 putative homodimer interface [polypeptide binding]; other site 1171373002527 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 1171373002528 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 1171373002529 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 1171373002530 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 1171373002531 active site 1171373002532 SAM binding site [chemical binding]; other site 1171373002533 homodimer interface [polypeptide binding]; other site 1171373002534 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1171373002535 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1171373002536 putative active site [active] 1171373002537 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 1171373002538 putative active site [active] 1171373002539 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 1171373002540 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1171373002541 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 1171373002542 Precorrin-8X methylmutase; Region: CbiC; pfam02570 1171373002543 cobalt transport protein CbiM; Validated; Region: PRK08319 1171373002544 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 1171373002545 cobalt transport protein CbiN; Provisional; Region: PRK02898 1171373002546 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 1171373002547 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1171373002548 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 1171373002549 Walker A/P-loop; other site 1171373002550 ATP binding site [chemical binding]; other site 1171373002551 Q-loop/lid; other site 1171373002552 ABC transporter signature motif; other site 1171373002553 Walker B; other site 1171373002554 D-loop; other site 1171373002555 H-loop/switch region; other site 1171373002556 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 1171373002557 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1171373002558 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 1171373002559 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 1171373002560 homodimer interface [polypeptide binding]; other site 1171373002561 Walker A motif; other site 1171373002562 ATP binding site [chemical binding]; other site 1171373002563 hydroxycobalamin binding site [chemical binding]; other site 1171373002564 Walker B motif; other site 1171373002565 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 1171373002566 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1171373002567 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 1171373002568 catalytic triad [active] 1171373002569 hypothetical protein; Provisional; Region: PRK07908 1171373002570 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1171373002571 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1171373002572 homodimer interface [polypeptide binding]; other site 1171373002573 catalytic residue [active] 1171373002574 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1171373002575 homodimer interface [polypeptide binding]; other site 1171373002576 active site 1171373002577 SAM binding site [chemical binding]; other site 1171373002578 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 1171373002579 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 1171373002580 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 1171373002581 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1171373002582 putative dimer interface [polypeptide binding]; other site 1171373002583 active site pocket [active] 1171373002584 putative cataytic base [active] 1171373002585 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 1171373002586 homotrimer interface [polypeptide binding]; other site 1171373002587 Walker A motif; other site 1171373002588 GTP binding site [chemical binding]; other site 1171373002589 Walker B motif; other site 1171373002590 cobalamin synthase; Reviewed; Region: cobS; PRK00235 1171373002591 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1171373002592 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1171373002593 intersubunit interface [polypeptide binding]; other site 1171373002594 S-ribosylhomocysteinase; Provisional; Region: PRK02260 1171373002595 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 1171373002596 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1171373002597 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1171373002598 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 1171373002599 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1171373002600 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1171373002601 ring oligomerisation interface [polypeptide binding]; other site 1171373002602 ATP/Mg binding site [chemical binding]; other site 1171373002603 stacking interactions; other site 1171373002604 hinge regions; other site 1171373002605 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1171373002606 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1171373002607 ligand binding site [chemical binding]; other site 1171373002608 CAAX protease self-immunity; Region: Abi; pfam02517 1171373002609 CutC family; Region: CutC; cl01218 1171373002610 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1171373002611 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1171373002612 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1171373002613 ATP binding site [chemical binding]; other site 1171373002614 putative Mg++ binding site [ion binding]; other site 1171373002615 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1171373002616 nucleotide binding region [chemical binding]; other site 1171373002617 ATP-binding site [chemical binding]; other site 1171373002618 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1171373002619 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1171373002620 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1171373002621 active site 1171373002622 trimer interface [polypeptide binding]; other site 1171373002623 allosteric site; other site 1171373002624 active site lid [active] 1171373002625 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1171373002626 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1171373002627 DNA-binding site [nucleotide binding]; DNA binding site 1171373002628 RNA-binding motif; other site 1171373002629 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 1171373002630 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1171373002631 phosphoserine aminotransferase; Provisional; Region: PRK03080 1171373002632 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1171373002633 catalytic residue [active] 1171373002634 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1171373002635 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1171373002636 active site 1171373002637 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1171373002638 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 1171373002639 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1171373002640 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1171373002641 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1171373002642 catalytic residues [active] 1171373002643 Transaldolase; Region: Transaldolase; pfam00923 1171373002644 transaldolase-like protein; Provisional; Region: PTZ00411 1171373002645 catalytic residue [active] 1171373002646 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1171373002647 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1171373002648 substrate binding site [chemical binding]; other site 1171373002649 ATP binding site [chemical binding]; other site 1171373002650 KduI/IolB family; Region: KduI; pfam04962 1171373002651 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 1171373002652 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1171373002653 PYR/PP interface [polypeptide binding]; other site 1171373002654 dimer interface [polypeptide binding]; other site 1171373002655 TPP binding site [chemical binding]; other site 1171373002656 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1171373002657 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 1171373002658 TPP-binding site; other site 1171373002659 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1171373002660 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1171373002661 DNA binding site [nucleotide binding] 1171373002662 domain linker motif; other site 1171373002663 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1171373002664 ligand binding site [chemical binding]; other site 1171373002665 dimerization interface [polypeptide binding]; other site 1171373002666 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1171373002667 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1171373002668 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1171373002669 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1171373002670 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1171373002671 putative substrate translocation pore; other site 1171373002672 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1171373002673 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1171373002674 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1171373002675 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1171373002676 Eukaryotic UGPase catalyses the synthesis of UDP-Glucose; Region: UGPase_euk; cd00897 1171373002677 active site 1171373002678 substrate binding site; other site 1171373002679 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1171373002680 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 1171373002681 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1171373002682 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 1171373002683 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 1171373002684 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1171373002685 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1171373002686 dimer interface [polypeptide binding]; other site 1171373002687 putative functional site; other site 1171373002688 putative MPT binding site; other site 1171373002689 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1171373002690 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1171373002691 RibD C-terminal domain; Region: RibD_C; cl17279 1171373002692 DJ-1 family protein; Region: not_thiJ; TIGR01383 1171373002693 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 1171373002694 conserved cys residue [active] 1171373002695 DinB superfamily; Region: DinB_2; pfam12867 1171373002696 aminotransferase; Validated; Region: PRK07337 1171373002697 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1171373002698 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1171373002699 homodimer interface [polypeptide binding]; other site 1171373002700 catalytic residue [active] 1171373002701 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 1171373002702 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 1171373002703 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1171373002704 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1171373002705 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1171373002706 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1171373002707 ATP binding site [chemical binding]; other site 1171373002708 putative Mg++ binding site [ion binding]; other site 1171373002709 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1171373002710 nucleotide binding region [chemical binding]; other site 1171373002711 ATP-binding site [chemical binding]; other site 1171373002712 TM1410 hypothetical-related protein; Region: DUF297; pfam03537 1171373002713 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1171373002714 dimerization interface [polypeptide binding]; other site 1171373002715 putative DNA binding site [nucleotide binding]; other site 1171373002716 putative Zn2+ binding site [ion binding]; other site 1171373002717 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1171373002718 putative hydrophobic ligand binding site [chemical binding]; other site 1171373002719 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1171373002720 hydrophobic ligand binding site; other site 1171373002721 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 1171373002722 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1171373002723 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1171373002724 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1171373002725 Protein of unknown function (DUF1684); Region: DUF1684; pfam07920 1171373002726 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1171373002727 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1171373002728 dimer interface [polypeptide binding]; other site 1171373002729 active site 1171373002730 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1171373002731 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1171373002732 HEAT repeats; Region: HEAT_2; pfam13646 1171373002733 Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788 1171373002734 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1171373002735 DNA binding residues [nucleotide binding] 1171373002736 putative dimer interface [polypeptide binding]; other site 1171373002737 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1171373002738 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1171373002739 proposed catalytic triad [active] 1171373002740 conserved cys residue [active] 1171373002741 Protein of unknown function (DUF1211); Region: DUF1211; pfam06736 1171373002742 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1171373002743 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1171373002744 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1171373002745 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 1171373002746 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1171373002747 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1171373002748 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1171373002749 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1171373002750 active site 1171373002751 phosphorylation site [posttranslational modification] 1171373002752 intermolecular recognition site; other site 1171373002753 dimerization interface [polypeptide binding]; other site 1171373002754 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1171373002755 DNA binding residues [nucleotide binding] 1171373002756 dimerization interface [polypeptide binding]; other site 1171373002757 Putative sensor; Region: Sensor; pfam13796 1171373002758 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1171373002759 Histidine kinase; Region: HisKA_3; pfam07730 1171373002760 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1171373002761 ATP binding site [chemical binding]; other site 1171373002762 Mg2+ binding site [ion binding]; other site 1171373002763 G-X-G motif; other site 1171373002764 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1171373002765 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1171373002766 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 1171373002767 Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818 1171373002768 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 1171373002769 putative active site [active] 1171373002770 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 1171373002771 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 1171373002772 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 1171373002773 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1171373002774 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1171373002775 active site 1171373002776 ATP binding site [chemical binding]; other site 1171373002777 substrate binding site [chemical binding]; other site 1171373002778 activation loop (A-loop); other site 1171373002779 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 1171373002780 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1171373002781 Predicted methyltransferases [General function prediction only]; Region: COG0313 1171373002782 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1171373002783 putative SAM binding site [chemical binding]; other site 1171373002784 putative homodimer interface [polypeptide binding]; other site 1171373002785 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1171373002786 active site 1171373002787 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1171373002788 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 1171373002789 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 1171373002790 MarR family; Region: MarR_2; cl17246 1171373002791 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1171373002792 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1171373002793 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 1171373002794 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1171373002795 Substrate binding site; other site 1171373002796 Mg++ binding site; other site 1171373002797 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1171373002798 active site 1171373002799 substrate binding site [chemical binding]; other site 1171373002800 CoA binding site [chemical binding]; other site 1171373002801 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1171373002802 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 1171373002803 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1171373002804 active site 1171373002805 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1171373002806 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1171373002807 5S rRNA interface [nucleotide binding]; other site 1171373002808 CTC domain interface [polypeptide binding]; other site 1171373002809 L16 interface [polypeptide binding]; other site 1171373002810 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1171373002811 putative active site [active] 1171373002812 catalytic residue [active] 1171373002813 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1171373002814 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1171373002815 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1171373002816 ATP binding site [chemical binding]; other site 1171373002817 putative Mg++ binding site [ion binding]; other site 1171373002818 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1171373002819 nucleotide binding region [chemical binding]; other site 1171373002820 ATP-binding site [chemical binding]; other site 1171373002821 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1171373002822 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12333 1171373002823 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1171373002824 homodimer interface [polypeptide binding]; other site 1171373002825 metal binding site [ion binding]; metal-binding site 1171373002826 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 1171373002827 enolase; Provisional; Region: eno; PRK00077 1171373002828 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1171373002829 dimer interface [polypeptide binding]; other site 1171373002830 metal binding site [ion binding]; metal-binding site 1171373002831 substrate binding pocket [chemical binding]; other site 1171373002832 Septum formation initiator; Region: DivIC; pfam04977 1171373002833 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1171373002834 Protein of unknown function (DUF501); Region: DUF501; pfam04417 1171373002835 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1171373002836 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1171373002837 Encapsulating protein for peroxidase; Region: Linocin_M18; pfam04454 1171373002838 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 1171373002839 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1171373002840 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1171373002841 Bax inhibitor 1 like; Region: BaxI_1; cl17691 1171373002842 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 1171373002843 nudix motif; other site 1171373002844 translation initiation factor IF-3; Region: infC; TIGR00168 1171373002845 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1171373002846 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1171373002847 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1171373002848 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1171373002849 23S rRNA binding site [nucleotide binding]; other site 1171373002850 L21 binding site [polypeptide binding]; other site 1171373002851 L13 binding site [polypeptide binding]; other site 1171373002852 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1171373002853 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1171373002854 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1171373002855 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 1171373002856 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1171373002857 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1171373002858 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1171373002859 dimer interface [polypeptide binding]; other site 1171373002860 motif 1; other site 1171373002861 active site 1171373002862 motif 2; other site 1171373002863 motif 3; other site 1171373002864 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1171373002865 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1171373002866 putative tRNA-binding site [nucleotide binding]; other site 1171373002867 B3/4 domain; Region: B3_4; pfam03483 1171373002868 tRNA synthetase B5 domain; Region: B5; pfam03484 1171373002869 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1171373002870 dimer interface [polypeptide binding]; other site 1171373002871 motif 1; other site 1171373002872 motif 3; other site 1171373002873 motif 2; other site 1171373002874 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1171373002875 biotin synthase; Validated; Region: PRK06256 1171373002876 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1171373002877 FeS/SAM binding site; other site 1171373002878 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1171373002879 tetracycline repressor protein TetR; Provisional; Region: PRK13756 1171373002880 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1171373002881 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1171373002882 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1171373002883 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1171373002884 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1171373002885 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1171373002886 active site 1171373002887 HIGH motif; other site 1171373002888 dimer interface [polypeptide binding]; other site 1171373002889 KMSKS motif; other site 1171373002890 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 1171373002891 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1171373002892 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 1171373002893 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1171373002894 ligand binding site [chemical binding]; other site 1171373002895 active site 1171373002896 UGI interface [polypeptide binding]; other site 1171373002897 catalytic site [active] 1171373002898 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1171373002899 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1171373002900 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1171373002901 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1171373002902 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1171373002903 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 1171373002904 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 1171373002905 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 1171373002906 catalytic residues [active] 1171373002907 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 1171373002908 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 1171373002909 catalytic residue [active] 1171373002910 putative FPP diphosphate binding site; other site 1171373002911 putative FPP binding hydrophobic cleft; other site 1171373002912 dimer interface [polypeptide binding]; other site 1171373002913 putative IPP diphosphate binding site; other site 1171373002914 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1171373002915 Haemolysin-III related; Region: HlyIII; pfam03006 1171373002916 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 1171373002917 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 1171373002918 putative active site [active] 1171373002919 PhoH-like protein; Region: PhoH; pfam02562 1171373002920 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 1171373002921 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1171373002922 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1171373002923 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1171373002924 generic binding surface II; other site 1171373002925 generic binding surface I; other site 1171373002926 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 1171373002927 RmuC family; Region: RmuC; pfam02646 1171373002928 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 1171373002929 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 1171373002930 active site 1171373002931 metal binding site [ion binding]; metal-binding site 1171373002932 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1171373002933 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1171373002934 Walker A/P-loop; other site 1171373002935 ATP binding site [chemical binding]; other site 1171373002936 Q-loop/lid; other site 1171373002937 ABC transporter signature motif; other site 1171373002938 Walker B; other site 1171373002939 D-loop; other site 1171373002940 H-loop/switch region; other site 1171373002941 FtsX-like permease family; Region: FtsX; pfam02687 1171373002942 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1171373002943 dimer interface [polypeptide binding]; other site 1171373002944 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1171373002945 dimer interface [polypeptide binding]; other site 1171373002946 GTP-binding protein YchF; Reviewed; Region: PRK09601 1171373002947 YchF GTPase; Region: YchF; cd01900 1171373002948 G1 box; other site 1171373002949 GTP/Mg2+ binding site [chemical binding]; other site 1171373002950 Switch I region; other site 1171373002951 G2 box; other site 1171373002952 Switch II region; other site 1171373002953 G3 box; other site 1171373002954 G4 box; other site 1171373002955 G5 box; other site 1171373002956 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1171373002957 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1171373002958 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1171373002959 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1171373002960 S-adenosylmethionine binding site [chemical binding]; other site 1171373002961 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1171373002962 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 1171373002963 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1171373002964 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1171373002965 ATP binding site [chemical binding]; other site 1171373002966 putative Mg++ binding site [ion binding]; other site 1171373002967 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 1171373002968 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1171373002969 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1171373002970 catalytic residues [active] 1171373002971 catalytic nucleophile [active] 1171373002972 Recombinase; Region: Recombinase; pfam07508 1171373002973 Antirestriction protein (ArdA); Region: ArdA; cl01953 1171373002974 hypothetical protein; Provisional; Region: PRK11281 1171373002975 Protein of unknown function (DUF3223); Region: DUF3223; pfam11523 1171373002976 Helix-turn-helix domain; Region: HTH_17; pfam12728 1171373002977 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 1171373002978 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 1171373002979 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1171373002980 non-specific DNA binding site [nucleotide binding]; other site 1171373002981 salt bridge; other site 1171373002982 sequence-specific DNA binding site [nucleotide binding]; other site 1171373002983 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1171373002984 Coenzyme A binding pocket [chemical binding]; other site 1171373002985 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1171373002986 Homeodomain-like domain; Region: HTH_23; pfam13384 1171373002987 Winged helix-turn helix; Region: HTH_29; pfam13551 1171373002988 Homeodomain-like domain; Region: HTH_32; pfam13565 1171373002989 Winged helix-turn helix; Region: HTH_33; pfam13592 1171373002990 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1171373002991 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1171373002992 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 1171373002993 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1171373002994 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1171373002995 Walker A/P-loop; other site 1171373002996 ATP binding site [chemical binding]; other site 1171373002997 Q-loop/lid; other site 1171373002998 ABC transporter signature motif; other site 1171373002999 Walker B; other site 1171373003000 D-loop; other site 1171373003001 H-loop/switch region; other site 1171373003002 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 1171373003003 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 1171373003004 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1171373003005 non-specific DNA binding site [nucleotide binding]; other site 1171373003006 salt bridge; other site 1171373003007 sequence-specific DNA binding site [nucleotide binding]; other site 1171373003008 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 1171373003009 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1171373003010 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1171373003011 Moco binding site; other site 1171373003012 metal coordination site [ion binding]; other site 1171373003013 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1171373003014 active site 1171373003015 NTP binding site [chemical binding]; other site 1171373003016 metal binding triad [ion binding]; metal-binding site 1171373003017 antibiotic binding site [chemical binding]; other site 1171373003018 Protein of unknown function DUF86; Region: DUF86; cl01031 1171373003019 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1171373003020 Coenzyme A binding pocket [chemical binding]; other site 1171373003021 Tetratrico peptide repeat; Region: TPR_5; pfam12688 1171373003022 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1171373003023 MULE transposase domain; Region: MULE; pfam10551 1171373003024 RibD C-terminal domain; Region: RibD_C; cl17279 1171373003025 RibD C-terminal domain; Region: RibD_C; cl17279 1171373003026 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 1171373003027 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 1171373003028 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 1171373003029 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1171373003030 Phosphotransferase enzyme family; Region: APH; pfam01636 1171373003031 active site 1171373003032 ATP binding site [chemical binding]; other site 1171373003033 substrate binding site [chemical binding]; other site 1171373003034 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1171373003035 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1171373003036 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1171373003037 Walker A/P-loop; other site 1171373003038 ATP binding site [chemical binding]; other site 1171373003039 Q-loop/lid; other site 1171373003040 ABC transporter signature motif; other site 1171373003041 Walker B; other site 1171373003042 D-loop; other site 1171373003043 H-loop/switch region; other site 1171373003044 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1171373003045 catalytic core [active] 1171373003046 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1171373003047 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1171373003048 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1171373003049 DNA binding residues [nucleotide binding] 1171373003050 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1171373003051 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1171373003052 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1171373003053 DNA binding site [nucleotide binding] 1171373003054 active site 1171373003055 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1171373003056 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1171373003057 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1171373003058 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1171373003059 ATP binding site [chemical binding]; other site 1171373003060 Mg2+ binding site [ion binding]; other site 1171373003061 G-X-G motif; other site 1171373003062 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1171373003063 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1171373003064 active site 1171373003065 phosphorylation site [posttranslational modification] 1171373003066 intermolecular recognition site; other site 1171373003067 dimerization interface [polypeptide binding]; other site 1171373003068 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1171373003069 DNA binding residues [nucleotide binding] 1171373003070 dimerization interface [polypeptide binding]; other site 1171373003071 Enoylreductase; Region: PKS_ER; smart00829 1171373003072 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1171373003073 NAD(P) binding site [chemical binding]; other site 1171373003074 proline/glycine betaine transporter; Provisional; Region: PRK10642 1171373003075 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1171373003076 putative substrate translocation pore; other site 1171373003077 proline/glycine betaine transporter; Provisional; Region: PRK10642 1171373003078 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1171373003079 putative substrate translocation pore; other site 1171373003080 CHAD domain; Region: CHAD; pfam05235 1171373003081 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1171373003082 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1171373003083 active site 1171373003084 motif I; other site 1171373003085 motif II; other site 1171373003086 ACT domain; Region: ACT_6; pfam13740 1171373003087 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 1171373003088 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869 1171373003089 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1171373003090 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1171373003091 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1171373003092 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1171373003093 active site 1171373003094 catalytic tetrad [active] 1171373003095 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1171373003096 dimer interface [polypeptide binding]; other site 1171373003097 catalytic triad [active] 1171373003098 peroxidatic and resolving cysteines [active] 1171373003099 lysine transporter; Provisional; Region: PRK10836 1171373003100 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like; cd11354 1171373003101 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1171373003102 active site 1171373003103 catalytic site [active] 1171373003104 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 1171373003105 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1171373003106 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1171373003107 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1171373003108 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1171373003109 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1171373003110 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 1171373003111 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 1171373003112 heterodimer interface [polypeptide binding]; other site 1171373003113 substrate interaction site [chemical binding]; other site 1171373003114 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1171373003115 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 1171373003116 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 1171373003117 active site 1171373003118 substrate binding site [chemical binding]; other site 1171373003119 coenzyme B12 binding site [chemical binding]; other site 1171373003120 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 1171373003121 B12 binding site [chemical binding]; other site 1171373003122 cobalt ligand [ion binding]; other site 1171373003123 membrane ATPase/protein kinase; Provisional; Region: PRK09435 1171373003124 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 1171373003125 Walker A; other site 1171373003126 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1171373003127 RNA binding surface [nucleotide binding]; other site 1171373003128 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1171373003129 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1171373003130 Walker A/P-loop; other site 1171373003131 ATP binding site [chemical binding]; other site 1171373003132 Q-loop/lid; other site 1171373003133 ABC transporter signature motif; other site 1171373003134 Walker B; other site 1171373003135 D-loop; other site 1171373003136 H-loop/switch region; other site 1171373003137 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1171373003138 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1171373003139 dimer interface [polypeptide binding]; other site 1171373003140 conserved gate region; other site 1171373003141 putative PBP binding loops; other site 1171373003142 ABC-ATPase subunit interface; other site 1171373003143 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1171373003144 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1171373003145 substrate binding pocket [chemical binding]; other site 1171373003146 membrane-bound complex binding site; other site 1171373003147 hinge residues; other site 1171373003148 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1171373003149 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1171373003150 substrate binding pocket [chemical binding]; other site 1171373003151 membrane-bound complex binding site; other site 1171373003152 hinge residues; other site 1171373003153 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1171373003154 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1171373003155 substrate binding pocket [chemical binding]; other site 1171373003156 membrane-bound complex binding site; other site 1171373003157 hinge residues; other site 1171373003158 Predicted transcriptional regulators [Transcription]; Region: COG1695 1171373003159 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1171373003160 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1171373003161 dimer interface [polypeptide binding]; other site 1171373003162 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1171373003163 putative PBP binding regions; other site 1171373003164 ABC-ATPase subunit interface; other site 1171373003165 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1171373003166 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1171373003167 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1171373003168 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1171373003169 intersubunit interface [polypeptide binding]; other site 1171373003170 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1171373003171 catalytic triad [active] 1171373003172 conserved cis-peptide bond; other site 1171373003173 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1171373003174 Na binding site [ion binding]; other site 1171373003175 Proline dehydrogenase; Region: Pro_dh; cl03282 1171373003176 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1171373003177 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1171373003178 NAD(P) binding site [chemical binding]; other site 1171373003179 catalytic residues [active] 1171373003180 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1171373003181 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1171373003182 NAD(P) binding site [chemical binding]; other site 1171373003183 dihydroxyacetone kinase; Provisional; Region: PRK14479 1171373003184 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 1171373003185 DAK2 domain; Region: Dak2; pfam02734 1171373003186 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 1171373003187 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1171373003188 active site 1171373003189 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1171373003190 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1171373003191 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1171373003192 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 1171373003193 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1171373003194 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1171373003195 active site 1171373003196 motif I; other site 1171373003197 motif II; other site 1171373003198 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1171373003199 Carbohydrate kinase and ribulose-phosphate 3-epimerase fusion proteins-like; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CarbK-RPE_like; cd07783 1171373003200 Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069 1171373003201 N- and C-terminal domain interface [polypeptide binding]; other site 1171373003202 active site 1171373003203 MgATP binding site [chemical binding]; other site 1171373003204 catalytic site [active] 1171373003205 metal binding site [ion binding]; metal-binding site 1171373003206 putative carbohydrate binding site [chemical binding]; other site 1171373003207 putative homodimer interface [polypeptide binding]; other site 1171373003208 Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175 1171373003209 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 1171373003210 active site 1171373003211 metal binding site [ion binding]; metal-binding site 1171373003212 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1171373003213 ribulokinase; Provisional; Region: PRK04123 1171373003214 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1171373003215 nucleotide binding site [chemical binding]; other site 1171373003216 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1171373003217 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1171373003218 TPP-binding site [chemical binding]; other site 1171373003219 dimer interface [polypeptide binding]; other site 1171373003220 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1171373003221 PYR/PP interface [polypeptide binding]; other site 1171373003222 dimer interface [polypeptide binding]; other site 1171373003223 TPP binding site [chemical binding]; other site 1171373003224 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1171373003225 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1171373003226 MarR family; Region: MarR; pfam01047 1171373003227 H+ Antiporter protein; Region: 2A0121; TIGR00900 1171373003228 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1171373003229 putative substrate translocation pore; other site 1171373003230 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 1171373003231 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 1171373003232 ligand binding site [chemical binding]; other site 1171373003233 homodimer interface [polypeptide binding]; other site 1171373003234 NAD(P) binding site [chemical binding]; other site 1171373003235 trimer interface B [polypeptide binding]; other site 1171373003236 trimer interface A [polypeptide binding]; other site 1171373003237 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 1171373003238 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 1171373003239 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 1171373003240 Beta-lactamase; Region: Beta-lactamase; cl17358 1171373003241 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1171373003242 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 1171373003243 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 1171373003244 VanW like protein; Region: VanW; pfam04294 1171373003245 Ferredoxin [Energy production and conversion]; Region: COG1146 1171373003246 4Fe-4S binding domain; Region: Fer4; pfam00037 1171373003247 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 1171373003248 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1171373003249 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1171373003250 homodimer interface [polypeptide binding]; other site 1171373003251 catalytic residue [active] 1171373003252 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1171373003253 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 1171373003254 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 1171373003255 putative trimer interface [polypeptide binding]; other site 1171373003256 putative CoA binding site [chemical binding]; other site 1171373003257 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 1171373003258 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 1171373003259 metal binding site [ion binding]; metal-binding site 1171373003260 putative dimer interface [polypeptide binding]; other site 1171373003261 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1171373003262 DivIVA domain; Region: DivI1A_domain; TIGR03544 1171373003263 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 1171373003264 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 1171373003265 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1171373003266 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 1171373003267 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1171373003268 ligand binding site; other site 1171373003269 oligomer interface; other site 1171373003270 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1171373003271 dimer interface [polypeptide binding]; other site 1171373003272 N-terminal domain interface [polypeptide binding]; other site 1171373003273 sulfate 1 binding site; other site 1171373003274 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 1171373003275 CGNR zinc finger; Region: zf-CGNR; pfam11706 1171373003276 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 1171373003277 putative active site [active] 1171373003278 redox center [active] 1171373003279 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1171373003280 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1171373003281 S-adenosylmethionine binding site [chemical binding]; other site 1171373003282 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1171373003283 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1171373003284 dimer interface [polypeptide binding]; other site 1171373003285 active site 1171373003286 catalytic residue [active] 1171373003287 sec-independent translocase; Provisional; Region: PRK01371 1171373003288 Domain of unknown function DUF59; Region: DUF59; cl00941 1171373003289 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1171373003290 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 1171373003291 Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286 1171373003292 MgtE intracellular N domain; Region: MgtE_N; pfam03448 1171373003293 FOG: CBS domain [General function prediction only]; Region: COG0517 1171373003294 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1171373003295 Methyltransferase domain; Region: Methyltransf_18; pfam12847 1171373003296 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1171373003297 proline aminopeptidase P II; Provisional; Region: PRK10879 1171373003298 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 1171373003299 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1171373003300 active site 1171373003301 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1171373003302 active site 1171373003303 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 1171373003304 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1171373003305 inhibitor-cofactor binding pocket; inhibition site 1171373003306 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1171373003307 catalytic residue [active] 1171373003308 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1171373003309 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 1171373003310 active site 1171373003311 catalytic triad [active] 1171373003312 dimer interface [polypeptide binding]; other site 1171373003313 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1171373003314 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 1171373003315 Putative zinc ribbon domain; Region: DUF164; pfam02591 1171373003316 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 1171373003317 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 1171373003318 oligomer interface [polypeptide binding]; other site 1171373003319 metal binding site [ion binding]; metal-binding site 1171373003320 metal binding site [ion binding]; metal-binding site 1171373003321 putative Cl binding site [ion binding]; other site 1171373003322 basic sphincter; other site 1171373003323 hydrophobic gate; other site 1171373003324 periplasmic entrance; other site 1171373003325 methionine aminopeptidase; Provisional; Region: PRK12318 1171373003326 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1171373003327 active site 1171373003328 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 1171373003329 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1171373003330 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1171373003331 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1171373003332 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 1171373003333 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1171373003334 metal binding triad; other site 1171373003335 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1171373003336 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1171373003337 metal binding triad; other site 1171373003338 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1171373003339 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1171373003340 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 1171373003341 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1171373003342 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1171373003343 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1171373003344 putative active site [active] 1171373003345 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 1171373003346 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1171373003347 sequence-specific DNA binding site [nucleotide binding]; other site 1171373003348 salt bridge; other site 1171373003349 glutamine synthetase, type I; Region: GlnA; TIGR00653 1171373003350 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1171373003351 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1171373003352 RDD family; Region: RDD; pfam06271 1171373003353 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 1171373003354 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1171373003355 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1171373003356 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1171373003357 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 1171373003358 FOG: CBS domain [General function prediction only]; Region: COG0517 1171373003359 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1171373003360 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1171373003361 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1171373003362 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1171373003363 Autophagy protein 16 (ATG16); Region: ATG16; pfam08614 1171373003364 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 1171373003365 Domain of unknown function (DUF4149); Region: DUF4149; pfam13664 1171373003366 lipoyl synthase; Provisional; Region: PRK05481 1171373003367 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1171373003368 FeS/SAM binding site; other site 1171373003369 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1171373003370 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1171373003371 metal-binding site [ion binding] 1171373003372 Protein of unknown function (DUF3754); Region: DUF3754; pfam12576 1171373003373 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1171373003374 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1171373003375 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 1171373003376 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1171373003377 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1171373003378 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1171373003379 E3 interaction surface; other site 1171373003380 lipoyl attachment site [posttranslational modification]; other site 1171373003381 e3 binding domain; Region: E3_binding; pfam02817 1171373003382 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1171373003383 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 1171373003384 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1171373003385 Glycerate kinase family; Region: Gly_kinase; cl00841 1171373003386 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 1171373003387 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 1171373003388 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1171373003389 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 1171373003390 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 1171373003391 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1171373003392 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1171373003393 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1171373003394 active site 1171373003395 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1171373003396 active site 1171373003397 DNA binding site [nucleotide binding] 1171373003398 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1171373003399 heme bH binding site [chemical binding]; other site 1171373003400 intrachain domain interface; other site 1171373003401 heme bL binding site [chemical binding]; other site 1171373003402 interchain domain interface [polypeptide binding]; other site 1171373003403 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 1171373003404 Qo binding site; other site 1171373003405 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1171373003406 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1171373003407 iron-sulfur cluster [ion binding]; other site 1171373003408 [2Fe-2S] cluster binding site [ion binding]; other site 1171373003409 Cytochrome c; Region: Cytochrom_C; pfam00034 1171373003410 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1171373003411 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 1171373003412 Subunit I/III interface [polypeptide binding]; other site 1171373003413 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1171373003414 active site 1171373003415 phosphorylation site [posttranslational modification] 1171373003416 intermolecular recognition site; other site 1171373003417 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1171373003418 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1171373003419 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1171373003420 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 1171373003421 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1171373003422 active site 1171373003423 Rhomboid family; Region: Rhomboid; cl11446 1171373003424 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1171373003425 AsnC family; Region: AsnC_trans_reg; pfam01037 1171373003426 hypothetical protein; Validated; Region: PRK07883 1171373003427 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1171373003428 active site 1171373003429 catalytic site [active] 1171373003430 substrate binding site [chemical binding]; other site 1171373003431 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1171373003432 GIY-YIG motif/motif A; other site 1171373003433 active site 1171373003434 catalytic site [active] 1171373003435 putative DNA binding site [nucleotide binding]; other site 1171373003436 metal binding site [ion binding]; metal-binding site 1171373003437 Integrase core domain; Region: rve; pfam00665 1171373003438 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1171373003439 NlpC/P60 family; Region: NLPC_P60; pfam00877 1171373003440 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 1171373003441 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1171373003442 nucleotide binding site [chemical binding]; other site 1171373003443 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1171373003444 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1171373003445 putative acyl-acceptor binding pocket; other site 1171373003446 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 1171373003447 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1171373003448 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1171373003449 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1171373003450 G-X-G motif; other site 1171373003451 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1171373003452 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1171373003453 active site 1171373003454 phosphorylation site [posttranslational modification] 1171373003455 intermolecular recognition site; other site 1171373003456 dimerization interface [polypeptide binding]; other site 1171373003457 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1171373003458 DNA binding residues [nucleotide binding] 1171373003459 dimerization interface [polypeptide binding]; other site 1171373003460 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 1171373003461 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1171373003462 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1171373003463 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1171373003464 EamA-like transporter family; Region: EamA; pfam00892 1171373003465 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1171373003466 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1171373003467 active site 1171373003468 ATP binding site [chemical binding]; other site 1171373003469 substrate binding site [chemical binding]; other site 1171373003470 activation loop (A-loop); other site 1171373003471 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1171373003472 thiamine phosphate binding site [chemical binding]; other site 1171373003473 active site 1171373003474 pyrophosphate binding site [ion binding]; other site 1171373003475 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1171373003476 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1171373003477 substrate binding pocket [chemical binding]; other site 1171373003478 chain length determination region; other site 1171373003479 substrate-Mg2+ binding site; other site 1171373003480 catalytic residues [active] 1171373003481 aspartate-rich region 1; other site 1171373003482 active site lid residues [active] 1171373003483 aspartate-rich region 2; other site 1171373003484 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1171373003485 FAD binding site [chemical binding]; other site 1171373003486 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1171373003487 Part of AAA domain; Region: AAA_19; pfam13245 1171373003488 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1171373003489 NMT1-like family; Region: NMT1_2; pfam13379 1171373003490 substrate binding pocket [chemical binding]; other site 1171373003491 membrane-bound complex binding site; other site 1171373003492 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1171373003493 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1171373003494 dimer interface [polypeptide binding]; other site 1171373003495 conserved gate region; other site 1171373003496 putative PBP binding loops; other site 1171373003497 ABC-ATPase subunit interface; other site 1171373003498 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1171373003499 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1171373003500 Walker A/P-loop; other site 1171373003501 ATP binding site [chemical binding]; other site 1171373003502 Q-loop/lid; other site 1171373003503 ABC transporter signature motif; other site 1171373003504 Walker B; other site 1171373003505 D-loop; other site 1171373003506 H-loop/switch region; other site 1171373003507 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1171373003508 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1171373003509 nucleophilic elbow; other site 1171373003510 catalytic triad; other site 1171373003511 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1171373003512 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1171373003513 putative dimer interface [polypeptide binding]; other site 1171373003514 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1171373003515 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490 1171373003516 GntP family permease; Region: GntP_permease; pfam02447 1171373003517 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1171373003518 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1171373003519 AAA domain; Region: AAA_33; pfam13671 1171373003520 ATP-binding site [chemical binding]; other site 1171373003521 Gluconate-6-phosphate binding site [chemical binding]; other site 1171373003522 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1171373003523 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1171373003524 DNA-binding site [nucleotide binding]; DNA binding site 1171373003525 FCD domain; Region: FCD; pfam07729 1171373003526 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1171373003527 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1171373003528 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1171373003529 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1171373003530 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1171373003531 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1171373003532 Walker A/P-loop; other site 1171373003533 ATP binding site [chemical binding]; other site 1171373003534 Q-loop/lid; other site 1171373003535 ABC transporter signature motif; other site 1171373003536 Walker B; other site 1171373003537 D-loop; other site 1171373003538 H-loop/switch region; other site 1171373003539 glycine dehydrogenase; Provisional; Region: PRK05367 1171373003540 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1171373003541 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1171373003542 catalytic residue [active] 1171373003543 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1171373003544 tetramer interface [polypeptide binding]; other site 1171373003545 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1171373003546 catalytic residue [active] 1171373003547 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1171373003548 lipoyl attachment site [posttranslational modification]; other site 1171373003549 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1171373003550 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1171373003551 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1171373003552 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 1171373003553 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1171373003554 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1171373003555 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1171373003556 Protein of unknown function DUF58; Region: DUF58; pfam01882 1171373003557 MoxR-like ATPases [General function prediction only]; Region: COG0714 1171373003558 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1171373003559 ATP binding site [chemical binding]; other site 1171373003560 Walker A motif; other site 1171373003561 Walker B motif; other site 1171373003562 arginine finger; other site 1171373003563 cell division protein MraZ; Reviewed; Region: PRK00326 1171373003564 MraZ protein; Region: MraZ; pfam02381 1171373003565 MraZ protein; Region: MraZ; pfam02381 1171373003566 MraW methylase family; Region: Methyltransf_5; cl17771 1171373003567 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1171373003568 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1171373003569 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1171373003570 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1171373003571 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1171373003572 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1171373003573 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1171373003574 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1171373003575 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1171373003576 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1171373003577 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1171373003578 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1171373003579 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1171373003580 Mg++ binding site [ion binding]; other site 1171373003581 putative catalytic motif [active] 1171373003582 putative substrate binding site [chemical binding]; other site 1171373003583 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438 1171373003584 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1171373003585 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 1171373003586 cell division protein FtsW; Region: ftsW; TIGR02614 1171373003587 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1171373003588 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1171373003589 active site 1171373003590 homodimer interface [polypeptide binding]; other site 1171373003591 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1171373003592 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1171373003593 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1171373003594 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1171373003595 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1171373003596 Cell division protein FtsQ; Region: FtsQ; pfam03799 1171373003597 cell division protein FtsZ; Validated; Region: PRK09330 1171373003598 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1171373003599 nucleotide binding site [chemical binding]; other site 1171373003600 SulA interaction site; other site 1171373003601 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1171373003602 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 1171373003603 Protein of unknown function (DUF552); Region: DUF552; pfam04472 1171373003604 YGGT family; Region: YGGT; cl00508 1171373003605 DivIVA domain; Region: DivI1A_domain; TIGR03544 1171373003606 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 1171373003607 Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252 1171373003608 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 1171373003609 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1171373003610 RNA binding surface [nucleotide binding]; other site 1171373003611 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1171373003612 active site 1171373003613 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1171373003614 pyruvate kinase; Provisional; Region: PRK06247 1171373003615 domain interfaces; other site 1171373003616 active site 1171373003617 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 1171373003618 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1171373003619 active site 1171373003620 phosphorylation site [posttranslational modification] 1171373003621 intermolecular recognition site; other site 1171373003622 dimerization interface [polypeptide binding]; other site 1171373003623 ANTAR domain; Region: ANTAR; pfam03861 1171373003624 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1171373003625 CoenzymeA binding site [chemical binding]; other site 1171373003626 subunit interaction site [polypeptide binding]; other site 1171373003627 PHB binding site; other site 1171373003628 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 1171373003629 active site 1171373003630 SAM binding site [chemical binding]; other site 1171373003631 homodimer interface [polypeptide binding]; other site 1171373003632 DNA polymerase I; Provisional; Region: PRK05755 1171373003633 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1171373003634 active site 1171373003635 metal binding site 1 [ion binding]; metal-binding site 1171373003636 putative 5' ssDNA interaction site; other site 1171373003637 metal binding site 3; metal-binding site 1171373003638 metal binding site 2 [ion binding]; metal-binding site 1171373003639 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1171373003640 putative DNA binding site [nucleotide binding]; other site 1171373003641 putative metal binding site [ion binding]; other site 1171373003642 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1171373003643 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1171373003644 active site 1171373003645 DNA binding site [nucleotide binding] 1171373003646 catalytic site [active] 1171373003647 FAD binding domain; Region: FAD_binding_4; pfam01565 1171373003648 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 1171373003649 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1171373003650 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1171373003651 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 1171373003652 active site 1171373003653 putative catalytic site [active] 1171373003654 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 1171373003655 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1171373003656 RNA binding site [nucleotide binding]; other site 1171373003657 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1171373003658 RNA binding site [nucleotide binding]; other site 1171373003659 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1171373003660 RNA binding site [nucleotide binding]; other site 1171373003661 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1171373003662 RNA binding site [nucleotide binding]; other site 1171373003663 domain interface; other site 1171373003664 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1171373003665 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1171373003666 CoA-binding site [chemical binding]; other site 1171373003667 ATP-binding [chemical binding]; other site 1171373003668 Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cl00425 1171373003669 excinuclease ABC subunit B; Provisional; Region: PRK05298 1171373003670 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1171373003671 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1171373003672 nucleotide binding region [chemical binding]; other site 1171373003673 ATP-binding site [chemical binding]; other site 1171373003674 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1171373003675 UvrB/uvrC motif; Region: UVR; pfam02151 1171373003676 Integral membrane protein TerC family; Region: TerC; cl10468 1171373003677 mycothiol-dependent maleylpyruvate isomerase; Reviewed; Region: PRK09583 1171373003678 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1171373003679 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1171373003680 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1171373003681 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1171373003682 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1171373003683 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1171373003684 iron-sulfur cluster [ion binding]; other site 1171373003685 [2Fe-2S] cluster binding site [ion binding]; other site 1171373003686 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1171373003687 catalytic core [active] 1171373003688 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1171373003689 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1171373003690 GIY-YIG motif/motif A; other site 1171373003691 active site 1171373003692 catalytic site [active] 1171373003693 putative DNA binding site [nucleotide binding]; other site 1171373003694 metal binding site [ion binding]; metal-binding site 1171373003695 UvrB/uvrC motif; Region: UVR; pfam02151 1171373003696 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1171373003697 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1171373003698 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1171373003699 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 1171373003700 phosphate binding site [ion binding]; other site 1171373003701 putative substrate binding pocket [chemical binding]; other site 1171373003702 dimer interface [polypeptide binding]; other site 1171373003703 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1171373003704 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1171373003705 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1171373003706 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1171373003707 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1171373003708 Phosphoglycerate kinase; Region: PGK; pfam00162 1171373003709 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1171373003710 substrate binding site [chemical binding]; other site 1171373003711 hinge regions; other site 1171373003712 ADP binding site [chemical binding]; other site 1171373003713 catalytic site [active] 1171373003714 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1171373003715 triosephosphate isomerase; Provisional; Region: PRK14567 1171373003716 substrate binding site [chemical binding]; other site 1171373003717 dimer interface [polypeptide binding]; other site 1171373003718 catalytic triad [active] 1171373003719 Preprotein translocase SecG subunit; Region: SecG; cl09123 1171373003720 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 1171373003721 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1171373003722 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1171373003723 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1171373003724 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 1171373003725 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1171373003726 active site 1171373003727 multimer interface [polypeptide binding]; other site 1171373003728 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 1171373003729 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1171373003730 B12 binding site [chemical binding]; other site 1171373003731 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1171373003732 FeS/SAM binding site; other site 1171373003733 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1171373003734 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1171373003735 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 1171373003736 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105 1171373003737 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 1171373003738 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1171373003739 homodimer interface [polypeptide binding]; other site 1171373003740 oligonucleotide binding site [chemical binding]; other site 1171373003741 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1171373003742 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1171373003743 GTPase CgtA; Reviewed; Region: obgE; PRK12296 1171373003744 GTP1/OBG; Region: GTP1_OBG; pfam01018 1171373003745 Obg GTPase; Region: Obg; cd01898 1171373003746 G1 box; other site 1171373003747 GTP/Mg2+ binding site [chemical binding]; other site 1171373003748 Switch I region; other site 1171373003749 G2 box; other site 1171373003750 G3 box; other site 1171373003751 Switch II region; other site 1171373003752 G4 box; other site 1171373003753 G5 box; other site 1171373003754 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1171373003755 gamma-glutamyl kinase; Provisional; Region: PRK05429 1171373003756 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1171373003757 nucleotide binding site [chemical binding]; other site 1171373003758 homotetrameric interface [polypeptide binding]; other site 1171373003759 putative phosphate binding site [ion binding]; other site 1171373003760 putative allosteric binding site; other site 1171373003761 PUA domain; Region: PUA; pfam01472 1171373003762 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1171373003763 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1171373003764 putative catalytic cysteine [active] 1171373003765 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1171373003766 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1171373003767 active site 1171373003768 (T/H)XGH motif; other site 1171373003769 Oligomerisation domain; Region: Oligomerisation; pfam02410 1171373003770 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1171373003771 catalytic core [active] 1171373003772 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1171373003773 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1171373003774 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1171373003775 putative DNA binding site [nucleotide binding]; other site 1171373003776 putative Zn2+ binding site [ion binding]; other site 1171373003777 AsnC family; Region: AsnC_trans_reg; pfam01037 1171373003778 TfoX N-terminal domain; Region: TfoX_N; cl17592 1171373003779 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1171373003780 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966 1171373003781 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1171373003782 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1171373003783 Walker A/P-loop; other site 1171373003784 ATP binding site [chemical binding]; other site 1171373003785 Q-loop/lid; other site 1171373003786 ABC transporter signature motif; other site 1171373003787 Walker B; other site 1171373003788 D-loop; other site 1171373003789 H-loop/switch region; other site 1171373003790 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1171373003791 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 1171373003792 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1171373003793 PemK-like protein; Region: PemK; pfam02452 1171373003794 PAS domain; Region: PAS_9; pfam13426 1171373003795 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1171373003796 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1171373003797 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1171373003798 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1171373003799 adenylosuccinate synthase; Region: purA; TIGR00184 1171373003800 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 1171373003801 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1171373003802 nucleoside/Zn binding site; other site 1171373003803 dimer interface [polypeptide binding]; other site 1171373003804 catalytic motif [active] 1171373003805 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1171373003806 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 1171373003807 catalytic residues [active] 1171373003808 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 1171373003809 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1171373003810 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1171373003811 HIGH motif; other site 1171373003812 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1171373003813 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1171373003814 active site 1171373003815 KMSKS motif; other site 1171373003816 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1171373003817 tRNA binding surface [nucleotide binding]; other site 1171373003818 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 1171373003819 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1171373003820 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1171373003821 Competence protein; Region: Competence; pfam03772 1171373003822 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 1171373003823 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1171373003824 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1171373003825 ATP binding site [chemical binding]; other site 1171373003826 putative Mg++ binding site [ion binding]; other site 1171373003827 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1171373003828 ATP-binding site [chemical binding]; other site 1171373003829 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1171373003830 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1171373003831 Alpha amylase catalytic domain found in Amylosucrase; Region: AmyAc_Amylosucrase; cd11324 1171373003832 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1171373003833 active site 1171373003834 catalytic site [active] 1171373003835 GTP-binding protein LepA; Provisional; Region: PRK05433 1171373003836 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1171373003837 G1 box; other site 1171373003838 putative GEF interaction site [polypeptide binding]; other site 1171373003839 GTP/Mg2+ binding site [chemical binding]; other site 1171373003840 Switch I region; other site 1171373003841 G2 box; other site 1171373003842 G3 box; other site 1171373003843 Switch II region; other site 1171373003844 G4 box; other site 1171373003845 G5 box; other site 1171373003846 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 1171373003847 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1171373003848 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1171373003849 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 1171373003850 DinB superfamily; Region: DinB_2; pfam12867 1171373003851 O-succinylbenzoate synthase; Provisional; Region: PRK02901 1171373003852 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 1171373003853 active site 1171373003854 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1171373003855 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 1171373003856 dimer interface [polypeptide binding]; other site 1171373003857 tetramer interface [polypeptide binding]; other site 1171373003858 PYR/PP interface [polypeptide binding]; other site 1171373003859 TPP binding site [chemical binding]; other site 1171373003860 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1171373003861 TPP-binding site [chemical binding]; other site 1171373003862 isochorismate synthase EntC; Provisional; Region: PRK15016 1171373003863 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1171373003864 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1171373003865 AMP binding site [chemical binding]; other site 1171373003866 active site 1171373003867 acyl-activating enzyme (AAE) consensus motif; other site 1171373003868 CoA binding site [chemical binding]; other site 1171373003869 naphthoate synthase; Region: PLN02921 1171373003870 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1171373003871 substrate binding site [chemical binding]; other site 1171373003872 oxyanion hole (OAH) forming residues; other site 1171373003873 trimer interface [polypeptide binding]; other site 1171373003874 Rhomboid family; Region: Rhomboid; pfam01694 1171373003875 acetyl-CoA synthetase; Provisional; Region: PRK00174 1171373003876 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1171373003877 active site 1171373003878 CoA binding site [chemical binding]; other site 1171373003879 acyl-activating enzyme (AAE) consensus motif; other site 1171373003880 AMP binding site [chemical binding]; other site 1171373003881 acetate binding site [chemical binding]; other site 1171373003882 acetyl-CoA synthetase; Provisional; Region: PRK00174 1171373003883 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1171373003884 active site 1171373003885 CoA binding site [chemical binding]; other site 1171373003886 acyl-activating enzyme (AAE) consensus motif; other site 1171373003887 AMP binding site [chemical binding]; other site 1171373003888 acetate binding site [chemical binding]; other site 1171373003889 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 1171373003890 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1171373003891 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1171373003892 Walker A/P-loop; other site 1171373003893 ATP binding site [chemical binding]; other site 1171373003894 Q-loop/lid; other site 1171373003895 ABC transporter signature motif; other site 1171373003896 Walker B; other site 1171373003897 D-loop; other site 1171373003898 H-loop/switch region; other site 1171373003899 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1171373003900 metabolite-proton symporter; Region: 2A0106; TIGR00883 1171373003901 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1171373003902 putative substrate translocation pore; other site 1171373003903 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1171373003904 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1171373003905 phosphate binding site [ion binding]; other site 1171373003906 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1171373003907 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1171373003908 dimer interface [polypeptide binding]; other site 1171373003909 conserved gate region; other site 1171373003910 putative PBP binding loops; other site 1171373003911 ABC-ATPase subunit interface; other site 1171373003912 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1171373003913 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1171373003914 ABC-ATPase subunit interface; other site 1171373003915 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1171373003916 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1171373003917 coproporphyrinogen III oxidase; Validated; Region: PRK05628 1171373003918 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1171373003919 FeS/SAM binding site; other site 1171373003920 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 1171373003921 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1171373003922 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1171373003923 active site 1171373003924 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1171373003925 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1171373003926 chaperone protein DnaJ; Provisional; Region: PRK14278 1171373003927 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1171373003928 HSP70 interaction site [polypeptide binding]; other site 1171373003929 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1171373003930 Zn binding sites [ion binding]; other site 1171373003931 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1171373003932 dimer interface [polypeptide binding]; other site 1171373003933 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 1171373003934 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1171373003935 L-iditol 2-dehydrogenase; Region: iditol_2_DH_like; cd08235 1171373003936 putative NAD(P) binding site [chemical binding]; other site 1171373003937 catalytic Zn binding site [ion binding]; other site 1171373003938 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 1171373003939 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 1171373003940 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 1171373003941 active site 1171373003942 P-loop; other site 1171373003943 phosphorylation site [posttranslational modification] 1171373003944 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1171373003945 active site 1171373003946 phosphorylation site [posttranslational modification] 1171373003947 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1171373003948 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1171373003949 ATP binding site [chemical binding]; other site 1171373003950 putative Mg++ binding site [ion binding]; other site 1171373003951 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1171373003952 nucleotide binding region [chemical binding]; other site 1171373003953 ATP-binding site [chemical binding]; other site 1171373003954 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1171373003955 putative trimer interface [polypeptide binding]; other site 1171373003956 putative CoA binding site [chemical binding]; other site 1171373003957 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 1171373003958 EamA-like transporter family; Region: EamA; pfam00892 1171373003959 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 1171373003960 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1171373003961 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1171373003962 Histidine kinase; Region: HisKA_3; pfam07730 1171373003963 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1171373003964 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1171373003965 active site 1171373003966 phosphorylation site [posttranslational modification] 1171373003967 intermolecular recognition site; other site 1171373003968 dimerization interface [polypeptide binding]; other site 1171373003969 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1171373003970 DNA binding residues [nucleotide binding] 1171373003971 dimerization interface [polypeptide binding]; other site 1171373003972 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 1171373003973 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1171373003974 Walker A/P-loop; other site 1171373003975 ATP binding site [chemical binding]; other site 1171373003976 Q-loop/lid; other site 1171373003977 ABC transporter signature motif; other site 1171373003978 Walker B; other site 1171373003979 D-loop; other site 1171373003980 H-loop/switch region; other site 1171373003981 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1171373003982 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1171373003983 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 1171373003984 putative active site [active] 1171373003985 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1171373003986 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1171373003987 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 1171373003988 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 1171373003989 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1171373003990 dimerization interface [polypeptide binding]; other site 1171373003991 putative DNA binding site [nucleotide binding]; other site 1171373003992 putative Zn2+ binding site [ion binding]; other site 1171373003993 H+ Antiporter protein; Region: 2A0121; TIGR00900 1171373003994 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1171373003995 putative substrate translocation pore; other site 1171373003996 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1171373003997 S-adenosylmethionine binding site [chemical binding]; other site 1171373003998 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1171373003999 PhoH-like protein; Region: PhoH; pfam02562 1171373004000 metal-binding heat shock protein; Provisional; Region: PRK00016 1171373004001 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1171373004002 Domain of unknown function DUF21; Region: DUF21; pfam01595 1171373004003 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1171373004004 Transporter associated domain; Region: CorC_HlyC; smart01091 1171373004005 GTPase Era; Reviewed; Region: era; PRK00089 1171373004006 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1171373004007 G1 box; other site 1171373004008 GTP/Mg2+ binding site [chemical binding]; other site 1171373004009 Switch I region; other site 1171373004010 G2 box; other site 1171373004011 Switch II region; other site 1171373004012 G3 box; other site 1171373004013 G4 box; other site 1171373004014 G5 box; other site 1171373004015 KH domain; Region: KH_2; pfam07650 1171373004016 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1171373004017 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1171373004018 active site 1171373004019 2-isopropylmalate synthase; Validated; Region: PRK03739 1171373004020 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 1171373004021 active site 1171373004022 catalytic residues [active] 1171373004023 metal binding site [ion binding]; metal-binding site 1171373004024 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1171373004025 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1171373004026 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1171373004027 substrate binding pocket [chemical binding]; other site 1171373004028 membrane-bound complex binding site; other site 1171373004029 hinge residues; other site 1171373004030 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1171373004031 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1171373004032 dimer interface [polypeptide binding]; other site 1171373004033 conserved gate region; other site 1171373004034 putative PBP binding loops; other site 1171373004035 ABC-ATPase subunit interface; other site 1171373004036 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1171373004037 dimer interface [polypeptide binding]; other site 1171373004038 conserved gate region; other site 1171373004039 putative PBP binding loops; other site 1171373004040 ABC-ATPase subunit interface; other site 1171373004041 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1171373004042 putative active site [active] 1171373004043 putative dimer interface [polypeptide binding]; other site 1171373004044 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 1171373004045 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1171373004046 catalytic residue [active] 1171373004047 putative FPP diphosphate binding site; other site 1171373004048 putative FPP binding hydrophobic cleft; other site 1171373004049 dimer interface [polypeptide binding]; other site 1171373004050 putative IPP diphosphate binding site; other site 1171373004051 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1171373004052 Coenzyme A binding pocket [chemical binding]; other site 1171373004053 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 1171373004054 catalytic triad [active] 1171373004055 putative active site [active] 1171373004056 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1171373004057 Recombination protein O N terminal; Region: RecO_N; pfam11967 1171373004058 Recombination protein O C terminal; Region: RecO_C; pfam02565 1171373004059 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1171373004060 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 1171373004061 putative NAD(P) binding site [chemical binding]; other site 1171373004062 myosin-cross-reactive antigen; Provisional; Region: PRK13977 1171373004063 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 1171373004064 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 1171373004065 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1171373004066 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1171373004067 catalytic residues [active] 1171373004068 catalytic nucleophile [active] 1171373004069 Presynaptic Site I dimer interface [polypeptide binding]; other site 1171373004070 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1171373004071 Synaptic Flat tetramer interface [polypeptide binding]; other site 1171373004072 Synaptic Site I dimer interface [polypeptide binding]; other site 1171373004073 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1171373004074 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 1171373004075 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 1171373004076 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1171373004077 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 1171373004078 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1171373004079 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 1171373004080 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 1171373004081 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 1171373004082 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 1171373004083 AAA-like domain; Region: AAA_10; pfam12846 1171373004084 Helix-turn-helix domain; Region: HTH_17; pfam12728 1171373004085 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1171373004086 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1171373004087 catalytic residue [active] 1171373004088 Surface antigen [General function prediction only]; Region: COG3942 1171373004089 CHAP domain; Region: CHAP; cl17642 1171373004090 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1171373004091 Helix-turn-helix domain; Region: HTH_36; pfam13730 1171373004092 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1171373004093 DNA binding residues [nucleotide binding] 1171373004094 Helix-turn-helix domain; Region: HTH_17; pfam12728 1171373004095 Integrase core domain; Region: rve; pfam00665 1171373004096 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1171373004097 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1171373004098 active site 1171373004099 motif I; other site 1171373004100 motif II; other site 1171373004101 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1171373004102 MoxR-like ATPases [General function prediction only]; Region: COG0714 1171373004103 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1171373004104 Walker A motif; other site 1171373004105 ATP binding site [chemical binding]; other site 1171373004106 Walker B motif; other site 1171373004107 arginine finger; other site 1171373004108 Protein of unknown function DUF58; Region: DUF58; pfam01882 1171373004109 von Willebrand factor type A domain; Region: VWA_2; pfam13519 1171373004110 metal ion-dependent adhesion site (MIDAS); other site 1171373004111 von Willebrand factor type A domain; Region: VWA_2; pfam13519 1171373004112 metal ion-dependent adhesion site (MIDAS); other site 1171373004113 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1171373004114 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1171373004115 catalytic residue [active] 1171373004116 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 1171373004117 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1171373004118 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1171373004119 dimer interface [polypeptide binding]; other site 1171373004120 active site 1171373004121 acyl carrier protein; Provisional; Region: acpP; PRK00982 1171373004122 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1171373004123 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1171373004124 dimer interface [polypeptide binding]; other site 1171373004125 active site 1171373004126 CoA binding pocket [chemical binding]; other site 1171373004127 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1171373004128 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1171373004129 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1171373004130 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1171373004131 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1171373004132 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cl00252 1171373004133 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1171373004134 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1171373004135 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1171373004136 dimer interface [polypeptide binding]; other site 1171373004137 TPP-binding site [chemical binding]; other site 1171373004138 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 1171373004139 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1171373004140 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1171373004141 active site 1171373004142 catalytic tetrad [active] 1171373004143 Yqey-like protein; Region: YqeY; pfam09424 1171373004144 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1171373004145 active site 1171373004146 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1171373004147 dihydroorotase; Validated; Region: pyrC; PRK09357 1171373004148 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1171373004149 active site 1171373004150 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1171373004151 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 1171373004152 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1171373004153 catalytic site [active] 1171373004154 subunit interface [polypeptide binding]; other site 1171373004155 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1171373004156 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1171373004157 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1171373004158 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1171373004159 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1171373004160 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1171373004161 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1171373004162 IMP binding site; other site 1171373004163 dimer interface [polypeptide binding]; other site 1171373004164 interdomain contacts; other site 1171373004165 partial ornithine binding site; other site 1171373004166 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 1171373004167 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 1171373004168 FAD binding pocket [chemical binding]; other site 1171373004169 FAD binding motif [chemical binding]; other site 1171373004170 phosphate binding motif [ion binding]; other site 1171373004171 beta-alpha-beta structure motif; other site 1171373004172 NAD binding pocket [chemical binding]; other site 1171373004173 Iron coordination center [ion binding]; other site 1171373004174 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 1171373004175 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 1171373004176 heterodimer interface [polypeptide binding]; other site 1171373004177 active site 1171373004178 FMN binding site [chemical binding]; other site 1171373004179 homodimer interface [polypeptide binding]; other site 1171373004180 substrate binding site [chemical binding]; other site 1171373004181 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1171373004182 active site 1171373004183 dimer interface [polypeptide binding]; other site 1171373004184 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1171373004185 active site 1171373004186 Uncharacterized protein family (UPF0158); Region: UPF0158; pfam03682 1171373004187 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 1171373004188 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 1171373004189 nucleotide binding site/active site [active] 1171373004190 HIT family signature motif; other site 1171373004191 catalytic residue [active] 1171373004192 Fructosamine kinase; Region: Fructosamin_kin; cl17579 1171373004193 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 1171373004194 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1171373004195 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1171373004196 FeS/SAM binding site; other site 1171373004197 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1171373004198 Competence-damaged protein; Region: CinA; pfam02464 1171373004199 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1171373004200 non-specific DNA binding site [nucleotide binding]; other site 1171373004201 salt bridge; other site 1171373004202 sequence-specific DNA binding site [nucleotide binding]; other site 1171373004203 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1171373004204 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1171373004205 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1171373004206 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 1171373004207 recombinase A; Provisional; Region: recA; PRK09354 1171373004208 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1171373004209 hexamer interface [polypeptide binding]; other site 1171373004210 Walker A motif; other site 1171373004211 ATP binding site [chemical binding]; other site 1171373004212 Walker B motif; other site 1171373004213 Domain of unknown function (DUF3552); Region: DUF3552; pfam12072 1171373004214 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1171373004215 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1171373004216 Zn2+ binding site [ion binding]; other site 1171373004217 Mg2+ binding site [ion binding]; other site 1171373004218 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 1171373004219 active site 1171373004220 catalytic residues [active] 1171373004221 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 1171373004222 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1171373004223 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1171373004224 FeS/SAM binding site; other site 1171373004225 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 1171373004226 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 1171373004227 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 1171373004228 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1171373004229 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1171373004230 catalytic residue [active] 1171373004231 chromosome segregation protein; Provisional; Region: PRK03918 1171373004232 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 1171373004233 Phage-related protein [Function unknown]; Region: COG4695; cl01923 1171373004234 Phage portal protein; Region: Phage_portal; pfam04860 1171373004235 Terminase-like family; Region: Terminase_6; pfam03237 1171373004236 HNH endonuclease; Region: HNH_3; pfam13392 1171373004237 AP2 domain; Region: AP2; pfam00847 1171373004238 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 1171373004239 Helix-turn-helix domain; Region: HTH_17; pfam12728 1171373004240 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1171373004241 MULE transposase domain; Region: MULE; pfam10551 1171373004242 Prophage antirepressor [Transcription]; Region: COG3617 1171373004243 BRO family, N-terminal domain; Region: Bro-N; smart01040 1171373004244 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 1171373004245 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1171373004246 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1171373004247 non-specific DNA binding site [nucleotide binding]; other site 1171373004248 salt bridge; other site 1171373004249 sequence-specific DNA binding site [nucleotide binding]; other site 1171373004250 Domain of unknown function DUF1828; Region: DUF1828; pfam08861 1171373004251 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1171373004252 non-specific DNA binding site [nucleotide binding]; other site 1171373004253 salt bridge; other site 1171373004254 sequence-specific DNA binding site [nucleotide binding]; other site 1171373004255 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1171373004256 active site 1171373004257 DNA binding site [nucleotide binding] 1171373004258 Int/Topo IB signature motif; other site 1171373004259 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 1171373004260 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1171373004261 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1171373004262 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1171373004263 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1171373004264 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1171373004265 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1171373004266 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1171373004267 HflX GTPase family; Region: HflX; cd01878 1171373004268 G1 box; other site 1171373004269 GTP/Mg2+ binding site [chemical binding]; other site 1171373004270 Switch I region; other site 1171373004271 G2 box; other site 1171373004272 G3 box; other site 1171373004273 Switch II region; other site 1171373004274 G4 box; other site 1171373004275 G5 box; other site 1171373004276 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1171373004277 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1171373004278 putative Mg++ binding site [ion binding]; other site 1171373004279 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1171373004280 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1171373004281 ATP cone domain; Region: ATP-cone; pfam03477 1171373004282 vitamin B12-dependent ribonucleotide reductase; Validated; Region: PRK06556 1171373004283 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 1171373004284 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 1171373004285 active site 1171373004286 dimer interface [polypeptide binding]; other site 1171373004287 effector binding site; other site 1171373004288 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1171373004289 TSCPD domain; Region: TSCPD; pfam12637 1171373004290 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1171373004291 trimer interface [polypeptide binding]; other site 1171373004292 active site 1171373004293 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1171373004294 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1171373004295 Ligand Binding Site [chemical binding]; other site 1171373004296 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1171373004297 Ligand Binding Site [chemical binding]; other site 1171373004298 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1171373004299 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 1171373004300 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 1171373004301 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1171373004302 ATP binding site [chemical binding]; other site 1171373004303 putative Mg++ binding site [ion binding]; other site 1171373004304 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1171373004305 nucleotide binding region [chemical binding]; other site 1171373004306 ATP-binding site [chemical binding]; other site 1171373004307 Helicase associated domain (HA2); Region: HA2; pfam04408 1171373004308 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 1171373004309 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 1171373004310 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 1171373004311 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1171373004312 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1171373004313 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1171373004314 Sigma-70, region 4; Region: Sigma70_r4; pfam04545 1171373004315 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 1171373004316 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1171373004317 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1171373004318 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1171373004319 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1171373004320 DNA binding residues [nucleotide binding] 1171373004321 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1171373004322 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1171373004323 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 1171373004324 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1171373004325 ATP binding site [chemical binding]; other site 1171373004326 Mg2+ binding site [ion binding]; other site 1171373004327 G-X-G motif; other site 1171373004328 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1171373004329 anchoring element; other site 1171373004330 dimer interface [polypeptide binding]; other site 1171373004331 ATP binding site [chemical binding]; other site 1171373004332 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1171373004333 active site 1171373004334 metal binding site [ion binding]; metal-binding site 1171373004335 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1171373004336 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 1171373004337 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1171373004338 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 1171373004339 active site clefts [active] 1171373004340 zinc binding site [ion binding]; other site 1171373004341 dimer interface [polypeptide binding]; other site 1171373004342 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 1171373004343 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1171373004344 CAP-like domain; other site 1171373004345 active site 1171373004346 primary dimer interface [polypeptide binding]; other site 1171373004347 Uncharacterized conserved protein [Function unknown]; Region: COG4850 1171373004348 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 1171373004349 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1171373004350 Predicted membrane protein [Function unknown]; Region: COG1297 1171373004351 putative oligopeptide transporter, OPT family; Region: TIGR00733 1171373004352 Uncharacterized conserved protein [Function unknown]; Region: COG3379 1171373004353 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 1171373004354 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 1171373004355 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 1171373004356 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 1171373004357 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 1171373004358 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1171373004359 trimer interface [polypeptide binding]; other site 1171373004360 active site 1171373004361 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 1171373004362 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1171373004363 ssDNA binding site; other site 1171373004364 generic binding surface II; other site 1171373004365 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1171373004366 TrkA-N domain; Region: TrkA_N; pfam02254 1171373004367 TrkA-C domain; Region: TrkA_C; pfam02080 1171373004368 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1171373004369 TrkA-N domain; Region: TrkA_N; pfam02254 1171373004370 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1171373004371 TRAM domain; Region: TRAM; cl01282 1171373004372 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1171373004373 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1171373004374 S-adenosylmethionine binding site [chemical binding]; other site 1171373004375 aconitate hydratase; Validated; Region: PRK09277 1171373004376 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1171373004377 substrate binding site [chemical binding]; other site 1171373004378 ligand binding site [chemical binding]; other site 1171373004379 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1171373004380 substrate binding site [chemical binding]; other site 1171373004381 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1171373004382 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1171373004383 TPP-binding site; other site 1171373004384 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1171373004385 PYR/PP interface [polypeptide binding]; other site 1171373004386 dimer interface [polypeptide binding]; other site 1171373004387 TPP binding site [chemical binding]; other site 1171373004388 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1171373004389 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 1171373004390 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1171373004391 catalytic site [active] 1171373004392 putative active site [active] 1171373004393 putative substrate binding site [chemical binding]; other site 1171373004394 HRDC domain; Region: HRDC; cl02578 1171373004395 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 1171373004396 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 1171373004397 SelR domain; Region: SelR; pfam01641 1171373004398 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 1171373004399 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1171373004400 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1171373004401 NodB motif; other site 1171373004402 active site 1171373004403 catalytic site [active] 1171373004404 metal binding site [ion binding]; metal-binding site 1171373004405 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1171373004406 Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506 1171373004407 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1171373004408 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1171373004409 putative NAD(P) binding site [chemical binding]; other site 1171373004410 putative substrate binding site [chemical binding]; other site 1171373004411 catalytic Zn binding site [ion binding]; other site 1171373004412 structural Zn binding site [ion binding]; other site 1171373004413 dimer interface [polypeptide binding]; other site 1171373004414 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 1171373004415 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1171373004416 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1171373004417 active site 1171373004418 dimer interface [polypeptide binding]; other site 1171373004419 motif 1; other site 1171373004420 motif 2; other site 1171373004421 motif 3; other site 1171373004422 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 1171373004423 anticodon binding site; other site 1171373004424 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 1171373004425 nucleotide binding site/active site [active] 1171373004426 HIT family signature motif; other site 1171373004427 catalytic residue [active] 1171373004428 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1171373004429 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1171373004430 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1171373004431 putative acyl-acceptor binding pocket; other site 1171373004432 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1171373004433 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1171373004434 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1171373004435 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1171373004436 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 1171373004437 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1171373004438 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1171373004439 lipoyl attachment site [posttranslational modification]; other site 1171373004440 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1171373004441 Double zinc ribbon; Region: DZR; pfam12773 1171373004442 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1171373004443 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1171373004444 phosphopeptide binding site; other site 1171373004445 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1171373004446 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1171373004447 DNA binding residues [nucleotide binding] 1171373004448 Bifunctional nuclease; Region: DNase-RNase; cl00553 1171373004449 helix_turn_helix, mercury resistance; Region: HTH_MERR; smart00422 1171373004450 DNA binding residues [nucleotide binding] 1171373004451 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1171373004452 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 1171373004453 pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated; Region: PRK06555 1171373004454 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 1171373004455 active site 1171373004456 ADP/pyrophosphate binding site [chemical binding]; other site 1171373004457 allosteric effector site; other site 1171373004458 dimerization interface [polypeptide binding]; other site 1171373004459 fructose-1,6-bisphosphate binding site; other site 1171373004460 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 1171373004461 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1171373004462 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1171373004463 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1171373004464 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1171373004465 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 1171373004466 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1171373004467 Beta-Casp domain; Region: Beta-Casp; smart01027 1171373004468 Actin-like ATPase involved in cell morphogenesis [Cell division and chromosome partitioning]; Region: MreB; COG1077 1171373004469 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 1171373004470 nucleotide binding site [chemical binding]; other site 1171373004471 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1171373004472 SBD interface [polypeptide binding]; other site 1171373004473 PAC2 family; Region: PAC2; pfam09754 1171373004474 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 1171373004475 Fe-S cluster binding site [ion binding]; other site 1171373004476 DNA binding site [nucleotide binding] 1171373004477 active site 1171373004478 hypothetical protein; Provisional; Region: PRK09256 1171373004479 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1171373004480 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 1171373004481 DXD motif; other site 1171373004482 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1171373004483 HlyD family secretion protein; Region: HlyD_3; pfam13437 1171373004484 Glycosyl hydrolase family 81; Region: Glyco_hydro_81; cl02310 1171373004485 amino acid transporter; Region: 2A0306; TIGR00909 1171373004486 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1171373004487 The HIRAN protein (HIP116, Rad5p N-terminal) is found in the N-terminal regions of the SWI2/SNF2 proteins typified by HIP116 and Rad5p; Region: HIRAN; smart00910 1171373004488 Protein of unknown function (DUF466); Region: DUF466; cl01082 1171373004489 carbon starvation protein A; Provisional; Region: PRK15015 1171373004490 Carbon starvation protein CstA; Region: CstA; pfam02554 1171373004491 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1171373004492 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 1171373004493 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1171373004494 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1171373004495 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1171373004496 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1171373004497 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1171373004498 non-specific DNA binding site [nucleotide binding]; other site 1171373004499 salt bridge; other site 1171373004500 sequence-specific DNA binding site [nucleotide binding]; other site 1171373004501 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1171373004502 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 1171373004503 putative active site [active] 1171373004504 pyridoxamine kinase; Validated; Region: PRK05756 1171373004505 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 1171373004506 pyridoxal binding site [chemical binding]; other site 1171373004507 dimer interface [polypeptide binding]; other site 1171373004508 ATP binding site [chemical binding]; other site 1171373004509 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 1171373004510 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 1171373004511 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 1171373004512 Ligand binding site; other site 1171373004513 Putative Catalytic site; other site 1171373004514 DXD motif; other site 1171373004515 apolipoprotein N-acyltransferase; Region: lnt; TIGR00546 1171373004516 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1171373004517 putative active site [active] 1171373004518 catalytic triad [active] 1171373004519 putative dimer interface [polypeptide binding]; other site 1171373004520 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1171373004521 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1171373004522 putative DNA binding site [nucleotide binding]; other site 1171373004523 putative Zn2+ binding site [ion binding]; other site 1171373004524 AsnC family; Region: AsnC_trans_reg; pfam01037 1171373004525 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1171373004526 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 1171373004527 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 1171373004528 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 1171373004529 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1171373004530 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1171373004531 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1171373004532 active site 1171373004533 catalytic tetrad [active] 1171373004534 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1171373004535 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1171373004536 active site 1171373004537 motif I; other site 1171373004538 motif II; other site 1171373004539 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1171373004540 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1171373004541 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1171373004542 active site 1171373004543 Integrase core domain; Region: rve; pfam00665 1171373004544 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1171373004545 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1171373004546 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1171373004547 non-specific DNA binding site [nucleotide binding]; other site 1171373004548 salt bridge; other site 1171373004549 sequence-specific DNA binding site [nucleotide binding]; other site 1171373004550 HipA N-terminal domain; Region: Couple_hipA; pfam13657 1171373004551 HipA-like N-terminal domain; Region: HipA_N; pfam07805 1171373004552 HipA-like C-terminal domain; Region: HipA_C; pfam07804 1171373004553 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 1171373004554 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1171373004555 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1171373004556 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 1171373004557 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 1171373004558 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 1171373004559 tetramer interface [polypeptide binding]; other site 1171373004560 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1171373004561 catalytic residue [active] 1171373004562 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 1171373004563 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1171373004564 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1171373004565 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1171373004566 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 1171373004567 homotrimer interaction site [polypeptide binding]; other site 1171373004568 putative active site [active] 1171373004569 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1171373004570 Coenzyme A binding pocket [chemical binding]; other site 1171373004571 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1171373004572 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1171373004573 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1171373004574 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1171373004575 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 1171373004576 inhibitor-cofactor binding pocket; inhibition site 1171373004577 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1171373004578 catalytic residue [active] 1171373004579 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1171373004580 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1171373004581 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 1171373004582 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1171373004583 RibD C-terminal domain; Region: RibD_C; cl17279 1171373004584 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1171373004585 DNA-binding site [nucleotide binding]; DNA binding site 1171373004586 polynucleotide kinase-phosphatase; Region: bacter_Pnkp; TIGR04075 1171373004587 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1171373004588 active site 1171373004589 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1171373004590 active site 1171373004591 metal binding site [ion binding]; metal-binding site 1171373004592 RNA repair, ligase-Pnkp-associating, region of Hen1; Region: Hen1_L; pfam12623 1171373004593 3' terminal RNA ribose 2'-O-methyltransferase Hen1; Region: bacter_Hen1; TIGR04074 1171373004594 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1171373004595 S-adenosylmethionine binding site [chemical binding]; other site 1171373004596 Protein of unknown function DUF45; Region: DUF45; pfam01863 1171373004597 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 1171373004598 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1171373004599 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1171373004600 ATP binding site [chemical binding]; other site 1171373004601 putative Mg++ binding site [ion binding]; other site 1171373004602 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1171373004603 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1171373004604 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1171373004605 MULE transposase domain; Region: MULE; pfam10551 1171373004606 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 1171373004607 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1171373004608 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1171373004609 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1171373004610 nudix motif; other site 1171373004611 OsmC-like protein; Region: OsmC; cl00767 1171373004612 Part of AAA domain; Region: AAA_19; pfam13245 1171373004613 Family description; Region: UvrD_C_2; pfam13538 1171373004614 GTP-binding protein Der; Reviewed; Region: PRK03003 1171373004615 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1171373004616 G1 box; other site 1171373004617 GTP/Mg2+ binding site [chemical binding]; other site 1171373004618 Switch I region; other site 1171373004619 G2 box; other site 1171373004620 Switch II region; other site 1171373004621 G3 box; other site 1171373004622 G4 box; other site 1171373004623 G5 box; other site 1171373004624 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1171373004625 G1 box; other site 1171373004626 GTP/Mg2+ binding site [chemical binding]; other site 1171373004627 Switch I region; other site 1171373004628 G2 box; other site 1171373004629 G3 box; other site 1171373004630 Switch II region; other site 1171373004631 G4 box; other site 1171373004632 G5 box; other site 1171373004633 cytidylate kinase; Provisional; Region: cmk; PRK00023 1171373004634 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1171373004635 CMP-binding site; other site 1171373004636 The sites determining sugar specificity; other site 1171373004637 prephenate dehydrogenase; Validated; Region: PRK06545 1171373004638 prephenate dehydrogenase; Validated; Region: PRK08507 1171373004639 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1171373004640 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 1171373004641 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 1171373004642 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 1171373004643 active site 1171373004644 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 1171373004645 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1171373004646 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1171373004647 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1171373004648 motif II; other site 1171373004649 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 1171373004650 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1171373004651 S-adenosylmethionine binding site [chemical binding]; other site 1171373004652 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1171373004653 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 1171373004654 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 1171373004655 substrate binding pocket [chemical binding]; other site 1171373004656 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1171373004657 B12 binding site [chemical binding]; other site 1171373004658 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1171373004659 PAC2 family; Region: PAC2; pfam09754 1171373004660 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1171373004661 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1171373004662 substrate binding site [chemical binding]; other site 1171373004663 hexamer interface [polypeptide binding]; other site 1171373004664 metal binding site [ion binding]; metal-binding site 1171373004665 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1171373004666 NusB family; Region: NusB; pfam01029 1171373004667 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1171373004668 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 1171373004669 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1171373004670 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1171373004671 putative active site [active] 1171373004672 substrate binding site [chemical binding]; other site 1171373004673 putative cosubstrate binding site; other site 1171373004674 catalytic site [active] 1171373004675 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1171373004676 substrate binding site [chemical binding]; other site 1171373004677 primosome assembly protein PriA; Provisional; Region: PRK14873 1171373004678 PemK-like protein; Region: PemK; pfam02452 1171373004679 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1171373004680 oligomeric interface; other site 1171373004681 putative active site [active] 1171373004682 homodimer interface [polypeptide binding]; other site 1171373004683 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 1171373004684 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1171373004685 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 1171373004686 putative DNA binding site [nucleotide binding]; other site 1171373004687 catalytic residue [active] 1171373004688 putative H2TH interface [polypeptide binding]; other site 1171373004689 putative catalytic residues [active] 1171373004690 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1171373004691 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1171373004692 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 1171373004693 ATP binding site [chemical binding]; other site 1171373004694 putative Mg++ binding site [ion binding]; other site 1171373004695 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1171373004696 nucleotide binding region [chemical binding]; other site 1171373004697 ATP-binding site [chemical binding]; other site 1171373004698 DEAD/H associated; Region: DEAD_assoc; pfam08494 1171373004699 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1171373004700 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1171373004701 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1171373004702 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1171373004703 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1171373004704 Flavoprotein; Region: Flavoprotein; pfam02441 1171373004705 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1171373004706 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 1171373004707 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1171373004708 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1171373004709 catalytic site [active] 1171373004710 G-X2-G-X-G-K; other site 1171373004711 transcription antitermination factor NusB; Region: nusB; TIGR01951 1171373004712 putative RNA binding site [nucleotide binding]; other site 1171373004713 elongation factor P; Validated; Region: PRK00529 1171373004714 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1171373004715 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1171373004716 RNA binding site [nucleotide binding]; other site 1171373004717 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1171373004718 RNA binding site [nucleotide binding]; other site 1171373004719 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1171373004720 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1171373004721 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1171373004722 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1171373004723 active site 1171373004724 dimer interface [polypeptide binding]; other site 1171373004725 metal binding site [ion binding]; metal-binding site 1171373004726 shikimate kinase; Reviewed; Region: aroK; PRK00131 1171373004727 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1171373004728 ADP binding site [chemical binding]; other site 1171373004729 magnesium binding site [ion binding]; other site 1171373004730 putative shikimate binding site; other site 1171373004731 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1171373004732 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1171373004733 Tetramer interface [polypeptide binding]; other site 1171373004734 active site 1171373004735 FMN-binding site [chemical binding]; other site 1171373004736 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1171373004737 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1171373004738 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1171373004739 shikimate binding site; other site 1171373004740 NAD(P) binding site [chemical binding]; other site 1171373004741 YceG-like family; Region: YceG; pfam02618 1171373004742 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1171373004743 dimerization interface [polypeptide binding]; other site 1171373004744 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 1171373004745 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1171373004746 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1171373004747 motif 1; other site 1171373004748 active site 1171373004749 motif 2; other site 1171373004750 motif 3; other site 1171373004751 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1171373004752 recombination factor protein RarA; Reviewed; Region: PRK13342 1171373004753 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1171373004754 Walker A motif; other site 1171373004755 ATP binding site [chemical binding]; other site 1171373004756 Walker B motif; other site 1171373004757 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1171373004758 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 1171373004759 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 1171373004760 active site 1171373004761 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 1171373004762 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 1171373004763 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1171373004764 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1171373004765 dimer interface [polypeptide binding]; other site 1171373004766 anticodon binding site; other site 1171373004767 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1171373004768 homodimer interface [polypeptide binding]; other site 1171373004769 motif 1; other site 1171373004770 active site 1171373004771 motif 2; other site 1171373004772 GAD domain; Region: GAD; pfam02938 1171373004773 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1171373004774 active site 1171373004775 motif 3; other site 1171373004776 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1171373004777 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1171373004778 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1171373004779 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1171373004780 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 1171373004781 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1171373004782 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 1171373004783 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 1171373004784 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 1171373004785 histidyl-tRNA synthetase; Region: hisS; TIGR00442 1171373004786 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1171373004787 dimer interface [polypeptide binding]; other site 1171373004788 motif 1; other site 1171373004789 active site 1171373004790 motif 2; other site 1171373004791 motif 3; other site 1171373004792 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1171373004793 anticodon binding site; other site 1171373004794 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1171373004795 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1171373004796 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1171373004797 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1171373004798 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1171373004799 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 1171373004800 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1171373004801 catalytic residue [active] 1171373004802 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1171373004803 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1171373004804 Zn2+ binding site [ion binding]; other site 1171373004805 Mg2+ binding site [ion binding]; other site 1171373004806 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1171373004807 synthetase active site [active] 1171373004808 NTP binding site [chemical binding]; other site 1171373004809 metal binding site [ion binding]; metal-binding site 1171373004810 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1171373004811 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1171373004812 Ion channel; Region: Ion_trans_2; pfam07885 1171373004813 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1171373004814 TrkA-N domain; Region: TrkA_N; pfam02254 1171373004815 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1171373004816 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1171373004817 Protein export membrane protein; Region: SecD_SecF; pfam02355 1171373004818 Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342 1171373004819 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1171373004820 Preprotein translocase subunit; Region: YajC; pfam02699 1171373004821 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1171373004822 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1171373004823 Walker A motif; other site 1171373004824 ATP binding site [chemical binding]; other site 1171373004825 Walker B motif; other site 1171373004826 arginine finger; other site 1171373004827 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1171373004828 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1171373004829 RuvA N terminal domain; Region: RuvA_N; pfam01330 1171373004830 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1171373004831 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 1171373004832 active site 1171373004833 putative DNA-binding cleft [nucleotide binding]; other site 1171373004834 dimer interface [polypeptide binding]; other site 1171373004835 hypothetical protein; Validated; Region: PRK00110 1171373004836 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1171373004837 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 1171373004838 catalytic residues [active] 1171373004839 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 1171373004840 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1171373004841 putative active site [active] 1171373004842 oxyanion strand; other site 1171373004843 catalytic triad [active] 1171373004844 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1171373004845 putative active site pocket [active] 1171373004846 4-fold oligomerization interface [polypeptide binding]; other site 1171373004847 metal binding residues [ion binding]; metal-binding site 1171373004848 3-fold/trimer interface [polypeptide binding]; other site 1171373004849 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 1171373004850 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1171373004851 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1171373004852 homodimer interface [polypeptide binding]; other site 1171373004853 catalytic residue [active] 1171373004854 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1171373004855 histidinol dehydrogenase; Region: hisD; TIGR00069 1171373004856 NAD binding site [chemical binding]; other site 1171373004857 dimerization interface [polypeptide binding]; other site 1171373004858 product binding site; other site 1171373004859 substrate binding site [chemical binding]; other site 1171373004860 zinc binding site [ion binding]; other site 1171373004861 catalytic residues [active] 1171373004862 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1171373004863 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 1171373004864 active site 1171373004865 PHP Thumb interface [polypeptide binding]; other site 1171373004866 metal binding site [ion binding]; metal-binding site 1171373004867 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1171373004868 generic binding surface II; other site 1171373004869 generic binding surface I; other site 1171373004870 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 1171373004871 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1171373004872 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1171373004873 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1171373004874 ABC-ATPase subunit interface; other site 1171373004875 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1171373004876 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1171373004877 dimer interface [polypeptide binding]; other site 1171373004878 conserved gate region; other site 1171373004879 putative PBP binding loops; other site 1171373004880 ABC-ATPase subunit interface; other site 1171373004881 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1171373004882 beta-galactosidase; Region: BGL; TIGR03356 1171373004883 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1171373004884 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1171373004885 DNA binding site [nucleotide binding] 1171373004886 domain linker motif; other site 1171373004887 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1171373004888 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 1171373004889 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1171373004890 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1171373004891 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1171373004892 active site 1171373004893 dimer interface [polypeptide binding]; other site 1171373004894 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1171373004895 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1171373004896 active site 1171373004897 FMN binding site [chemical binding]; other site 1171373004898 substrate binding site [chemical binding]; other site 1171373004899 3Fe-4S cluster binding site [ion binding]; other site 1171373004900 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1171373004901 domain interface; other site 1171373004902 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1171373004903 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1171373004904 substrate binding site [chemical binding]; other site 1171373004905 active site 1171373004906 catalytic residues [active] 1171373004907 heterodimer interface [polypeptide binding]; other site 1171373004908 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1171373004909 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1171373004910 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1171373004911 catalytic residue [active] 1171373004912 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1171373004913 active site 1171373004914 ribulose/triose binding site [chemical binding]; other site 1171373004915 phosphate binding site [ion binding]; other site 1171373004916 substrate (anthranilate) binding pocket [chemical binding]; other site 1171373004917 product (indole) binding pocket [chemical binding]; other site 1171373004918 anthranilate synthase component I; Provisional; Region: PRK13571 1171373004919 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1171373004920 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1171373004921 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1171373004922 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1171373004923 active site 1171373004924 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1171373004925 metal binding site 2 [ion binding]; metal-binding site 1171373004926 putative DNA binding helix; other site 1171373004927 metal binding site 1 [ion binding]; metal-binding site 1171373004928 dimer interface [polypeptide binding]; other site 1171373004929 structural Zn2+ binding site [ion binding]; other site 1171373004930 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 1171373004931 glycyl-tRNA synthetase; Provisional; Region: PRK04173 1171373004932 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1171373004933 motif 1; other site 1171373004934 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 1171373004935 active site 1171373004936 motif 2; other site 1171373004937 motif 3; other site 1171373004938 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 1171373004939 anticodon binding site; other site 1171373004940 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 1171373004941 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1171373004942 dimerization interface [polypeptide binding]; other site 1171373004943 active site 1171373004944 L-aspartate oxidase; Provisional; Region: PRK07804 1171373004945 L-aspartate oxidase; Provisional; Region: PRK06175 1171373004946 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1171373004947 quinolinate synthetase; Provisional; Region: PRK09375 1171373004948 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1171373004949 nudix motif; other site 1171373004950 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 1171373004951 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 1171373004952 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1171373004953 catalytic residue [active] 1171373004954 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 1171373004955 putative Iron-sulfur protein interface [polypeptide binding]; other site 1171373004956 proximal heme binding site [chemical binding]; other site 1171373004957 distal heme binding site [chemical binding]; other site 1171373004958 putative dimer interface [polypeptide binding]; other site 1171373004959 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 1171373004960 L-aspartate oxidase; Provisional; Region: PRK06175 1171373004961 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1171373004962 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 1171373004963 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1171373004964 4Fe-4S binding domain; Region: Fer4; pfam00037 1171373004965 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1171373004966 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1171373004967 active site 1171373004968 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 1171373004969 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1171373004970 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1171373004971 FMN binding site [chemical binding]; other site 1171373004972 active site 1171373004973 catalytic residues [active] 1171373004974 substrate binding site [chemical binding]; other site 1171373004975 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 1171373004976 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1171373004977 Zn2+ binding site [ion binding]; other site 1171373004978 Mg2+ binding site [ion binding]; other site 1171373004979 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1171373004980 DNA primase; Validated; Region: dnaG; PRK05667 1171373004981 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1171373004982 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1171373004983 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1171373004984 active site 1171373004985 metal binding site [ion binding]; metal-binding site 1171373004986 interdomain interaction site; other site 1171373004987 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 1171373004988 DNA-directed RNA polymerase specialized sigma subunit [Transcription]; Region: FliA; COG1191 1171373004989 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1171373004990 Sigma-70, region 4; Region: Sigma70_r4; pfam04545 1171373004991 DNA binding residues [nucleotide binding] 1171373004992 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1171373004993 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1171373004994 Walker A/P-loop; other site 1171373004995 ATP binding site [chemical binding]; other site 1171373004996 Q-loop/lid; other site 1171373004997 ABC transporter signature motif; other site 1171373004998 Walker B; other site 1171373004999 D-loop; other site 1171373005000 H-loop/switch region; other site 1171373005001 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1171373005002 heme ABC exporter, ATP-binding protein CcmA; Region: ccmA; TIGR01189 1171373005003 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 1171373005004 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 1171373005005 active site 1171373005006 homotetramer interface [polypeptide binding]; other site 1171373005007 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 1171373005008 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 1171373005009 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1171373005010 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1171373005011 dimer interface [polypeptide binding]; other site 1171373005012 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1171373005013 catalytic residue [active] 1171373005014 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 1171373005015 Tic20-like protein; Region: Tic20; pfam09685 1171373005016 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1171373005017 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1171373005018 DNA-binding site [nucleotide binding]; DNA binding site 1171373005019 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1171373005020 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1171373005021 homodimer interface [polypeptide binding]; other site 1171373005022 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1171373005023 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1171373005024 active site 1171373005025 multimer interface [polypeptide binding]; other site 1171373005026 imidazole glycerol phosphate synthase subunit hisH; Provisional; Region: hisH; CHL00188 1171373005027 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1171373005028 predicted active site [active] 1171373005029 catalytic triad [active] 1171373005030 Lysine efflux permease [General function prediction only]; Region: COG1279 1171373005031 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1171373005032 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 1171373005033 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1171373005034 dimerization interface [polypeptide binding]; other site 1171373005035 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1171373005036 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1171373005037 active site 1171373005038 ATP binding site [chemical binding]; other site 1171373005039 substrate binding site [chemical binding]; other site 1171373005040 activation loop (A-loop); other site 1171373005041 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1171373005042 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1171373005043 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1171373005044 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1171373005045 putative substrate translocation pore; other site 1171373005046 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1171373005047 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1171373005048 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1171373005049 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1171373005050 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1171373005051 Coenzyme A binding pocket [chemical binding]; other site 1171373005052 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1171373005053 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1171373005054 active site 1171373005055 catalytic residues [active] 1171373005056 DNA binding site [nucleotide binding] 1171373005057 Int/Topo IB signature motif; other site 1171373005058 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1171373005059 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1171373005060 Magnesium ion binding site [ion binding]; other site 1171373005061 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1171373005062 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 1171373005063 active site 1171373005064 NTP binding site [chemical binding]; other site 1171373005065 metal binding triad [ion binding]; metal-binding site 1171373005066 ThiF family; Region: ThiF; pfam00899 1171373005067 ATP binding site [chemical binding]; other site 1171373005068 substrate interface [chemical binding]; other site 1171373005069 TIR domain; Region: TIR_2; pfam13676 1171373005070 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1171373005071 multiple promoter invertase; Provisional; Region: mpi; PRK13413 1171373005072 catalytic residues [active] 1171373005073 catalytic nucleophile [active] 1171373005074 Presynaptic Site I dimer interface [polypeptide binding]; other site 1171373005075 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1171373005076 Synaptic Flat tetramer interface [polypeptide binding]; other site 1171373005077 Synaptic Site I dimer interface [polypeptide binding]; other site 1171373005078 DNA binding site [nucleotide binding] 1171373005079 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1171373005080 DNA-binding interface [nucleotide binding]; DNA binding site 1171373005081 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 1171373005082 Cadmium resistance transporter; Region: Cad; pfam03596 1171373005083 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1171373005084 dimerization interface [polypeptide binding]; other site 1171373005085 putative DNA binding site [nucleotide binding]; other site 1171373005086 putative Zn2+ binding site [ion binding]; other site 1171373005087 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1171373005088 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1171373005089 catalytic residues [active] 1171373005090 catalytic nucleophile [active] 1171373005091 Presynaptic Site I dimer interface [polypeptide binding]; other site 1171373005092 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1171373005093 Synaptic Flat tetramer interface [polypeptide binding]; other site 1171373005094 Synaptic Site I dimer interface [polypeptide binding]; other site 1171373005095 DNA binding site [nucleotide binding] 1171373005096 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1171373005097 DNA-binding interface [nucleotide binding]; DNA binding site 1171373005098 Integrase core domain; Region: rve; pfam00665 1171373005099 Integrase core domain; Region: rve_3; cl15866 1171373005100 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 1171373005101 Uncharacterized ATPase, putative transposase [General function prediction only]; Region: COG2842 1171373005102 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1171373005103 TIGR03085 family protein; Region: TIGR03085 1171373005104 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1171373005105 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1171373005106 GatB domain; Region: GatB_Yqey; smart00845 1171373005107 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1171373005108 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1171373005109 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1171373005110 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 1171373005111 NMT1/THI5 like; Region: NMT1; pfam09084 1171373005112 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1171373005113 membrane-bound complex binding site; other site 1171373005114 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1171373005115 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1171373005116 dimer interface [polypeptide binding]; other site 1171373005117 conserved gate region; other site 1171373005118 putative PBP binding loops; other site 1171373005119 ABC-ATPase subunit interface; other site 1171373005120 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1171373005121 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1171373005122 Walker A/P-loop; other site 1171373005123 ATP binding site [chemical binding]; other site 1171373005124 Q-loop/lid; other site 1171373005125 ABC transporter signature motif; other site 1171373005126 Walker B; other site 1171373005127 D-loop; other site 1171373005128 H-loop/switch region; other site 1171373005129 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 1171373005130 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 1171373005131 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1171373005132 Ligand Binding Site [chemical binding]; other site 1171373005133 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1171373005134 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 1171373005135 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1171373005136 catalytic residue [active] 1171373005137 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1171373005138 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1171373005139 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1171373005140 active site 1171373005141 catalytic site [active] 1171373005142 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 1171373005143 putative homodimer interface [polypeptide binding]; other site 1171373005144 putative active site pocket [active] 1171373005145 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 1171373005146 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 1171373005147 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 1171373005148 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1171373005149 active site 1171373005150 homodimer interface [polypeptide binding]; other site 1171373005151 catalytic site [active] 1171373005152 acceptor binding site [chemical binding]; other site 1171373005153 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 1171373005154 glycogen branching enzyme; Provisional; Region: PRK12313 1171373005155 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1171373005156 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1171373005157 active site 1171373005158 catalytic site [active] 1171373005159 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1171373005160 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1171373005161 active site turn [active] 1171373005162 phosphorylation site [posttranslational modification] 1171373005163 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1171373005164 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 1171373005165 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1171373005166 HPr interaction site; other site 1171373005167 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1171373005168 active site 1171373005169 phosphorylation site [posttranslational modification] 1171373005170 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 1171373005171 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1171373005172 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1171373005173 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1171373005174 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 1171373005175 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 1171373005176 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1171373005177 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1171373005178 phosphoglucomutase; Validated; Region: PRK07564 1171373005179 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 1171373005180 active site 1171373005181 substrate binding site [chemical binding]; other site 1171373005182 metal binding site [ion binding]; metal-binding site 1171373005183 Bacterial PH domain; Region: DUF304; pfam03703 1171373005184 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 1171373005185 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1171373005186 dimer interface [polypeptide binding]; other site 1171373005187 substrate binding site [chemical binding]; other site 1171373005188 metal binding site [ion binding]; metal-binding site 1171373005189 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 1171373005190 phosphodiesterase; Provisional; Region: PRK12704 1171373005191 hypothetical protein; Provisional; Region: PRK03298 1171373005192 acyl-CoA esterase; Provisional; Region: PRK10673 1171373005193 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1171373005194 catalytic site [active] 1171373005195 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1171373005196 active site 1171373005197 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 1171373005198 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 1171373005199 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1171373005200 gamma subunit interface [polypeptide binding]; other site 1171373005201 epsilon subunit interface [polypeptide binding]; other site 1171373005202 LBP interface [polypeptide binding]; other site 1171373005203 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1171373005204 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1171373005205 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1171373005206 alpha subunit interaction interface [polypeptide binding]; other site 1171373005207 Walker A motif; other site 1171373005208 ATP binding site [chemical binding]; other site 1171373005209 Walker B motif; other site 1171373005210 inhibitor binding site; inhibition site 1171373005211 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1171373005212 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1171373005213 core domain interface [polypeptide binding]; other site 1171373005214 delta subunit interface [polypeptide binding]; other site 1171373005215 epsilon subunit interface [polypeptide binding]; other site 1171373005216 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1171373005217 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1171373005218 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1171373005219 beta subunit interaction interface [polypeptide binding]; other site 1171373005220 Walker A motif; other site 1171373005221 ATP binding site [chemical binding]; other site 1171373005222 Walker B motif; other site 1171373005223 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1171373005224 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210 1171373005225 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1171373005226 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1171373005227 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1171373005228 ATP synthase subunit C; Region: ATP-synt_C; cl00466 1171373005229 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1171373005230 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1171373005231 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 1171373005232 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1171373005233 active site 1171373005234 substrate binding site [chemical binding]; other site 1171373005235 trimer interface [polypeptide binding]; other site 1171373005236 CoA binding site [chemical binding]; other site 1171373005237 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 1171373005238 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1171373005239 active site 1171373005240 dimer interface [polypeptide binding]; other site 1171373005241 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1171373005242 Ligand Binding Site [chemical binding]; other site 1171373005243 Molecular Tunnel; other site 1171373005244 NAD synthetase; Reviewed; Region: nadE; PRK00876 1171373005245 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1171373005246 homodimer interface [polypeptide binding]; other site 1171373005247 NAD binding pocket [chemical binding]; other site 1171373005248 ATP binding pocket [chemical binding]; other site 1171373005249 Mg binding site [ion binding]; other site 1171373005250 active-site loop [active] 1171373005251 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1171373005252 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1171373005253 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1171373005254 acyl-activating enzyme (AAE) consensus motif; other site 1171373005255 acyl-activating enzyme (AAE) consensus motif; other site 1171373005256 AMP binding site [chemical binding]; other site 1171373005257 active site 1171373005258 CoA binding site [chemical binding]; other site 1171373005259 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 1171373005260 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1171373005261 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1171373005262 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 1171373005263 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1171373005264 active site 1171373005265 dimer interface [polypeptide binding]; other site 1171373005266 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1171373005267 Ligand Binding Site [chemical binding]; other site 1171373005268 Molecular Tunnel; other site 1171373005269 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 1171373005270 putative homodimer interface [polypeptide binding]; other site 1171373005271 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 1171373005272 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1171373005273 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1171373005274 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1171373005275 active site 1171373005276 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1171373005277 Putative rhamnosyl transferase; Region: Rhamno_transf; pfam11316 1171373005278 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 1171373005279 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 1171373005280 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1171373005281 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 1171373005282 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1171373005283 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1171373005284 Mg++ binding site [ion binding]; other site 1171373005285 putative catalytic motif [active] 1171373005286 substrate binding site [chemical binding]; other site 1171373005287 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1171373005288 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1171373005289 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1171373005290 S-adenosylmethionine binding site [chemical binding]; other site 1171373005291 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1171373005292 PCRF domain; Region: PCRF; pfam03462 1171373005293 RF-1 domain; Region: RF-1; pfam00472 1171373005294 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1171373005295 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1171373005296 transcription termination factor Rho; Provisional; Region: PRK12608 1171373005297 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1171373005298 RNA binding site [nucleotide binding]; other site 1171373005299 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1171373005300 Walker A motif; other site 1171373005301 ATP binding site [chemical binding]; other site 1171373005302 Walker B motif; other site 1171373005303 homoserine kinase; Provisional; Region: PRK01212 1171373005304 homoserine dehydrogenase; Provisional; Region: PRK06349 1171373005305 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1171373005306 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1171373005307 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1171373005308 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1171373005309 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1171373005310 active site 1171373005311 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1171373005312 substrate binding site [chemical binding]; other site 1171373005313 catalytic residues [active] 1171373005314 dimer interface [polypeptide binding]; other site 1171373005315 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1171373005316 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 1171373005317 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1171373005318 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1171373005319 TPP-binding site [chemical binding]; other site 1171373005320 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1171373005321 Transcription factor WhiB; Region: Whib; pfam02467 1171373005322 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 1171373005323 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1171373005324 Histidine kinase; Region: HisKA_2; pfam07568 1171373005325 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1171373005326 ATP binding site [chemical binding]; other site 1171373005327 Mg2+ binding site [ion binding]; other site 1171373005328 G-X-G motif; other site 1171373005329 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 1171373005330 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 1171373005331 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1171373005332 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1171373005333 DNA binding residues [nucleotide binding] 1171373005334 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1171373005335 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1171373005336 hinge; other site 1171373005337 active site 1171373005338 Predicted GTPases [General function prediction only]; Region: COG1162 1171373005339 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1171373005340 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1171373005341 GTP/Mg2+ binding site [chemical binding]; other site 1171373005342 G4 box; other site 1171373005343 G5 box; other site 1171373005344 G1 box; other site 1171373005345 Switch I region; other site 1171373005346 G2 box; other site 1171373005347 G3 box; other site 1171373005348 Switch II region; other site 1171373005349 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 1171373005350 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 1171373005351 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1171373005352 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 1171373005353 active site 1171373005354 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 1171373005355 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 1171373005356 ligand binding site [chemical binding]; other site 1171373005357 NAD binding site [chemical binding]; other site 1171373005358 tetramer interface [polypeptide binding]; other site 1171373005359 catalytic site [active] 1171373005360 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 1171373005361 L-serine binding site [chemical binding]; other site 1171373005362 ACT domain interface; other site 1171373005363 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1171373005364 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1171373005365 putative PBP binding loops; other site 1171373005366 dimer interface [polypeptide binding]; other site 1171373005367 ABC-ATPase subunit interface; other site 1171373005368 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1171373005369 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1171373005370 dimer interface [polypeptide binding]; other site 1171373005371 conserved gate region; other site 1171373005372 putative PBP binding loops; other site 1171373005373 ABC-ATPase subunit interface; other site 1171373005374 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 1171373005375 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1171373005376 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 1171373005377 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1171373005378 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1171373005379 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1171373005380 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1171373005381 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 1171373005382 Uncharacterized conserved protein [Function unknown]; Region: COG1615 1171373005383 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1171373005384 Ligand Binding Site [chemical binding]; other site 1171373005385 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1171373005386 protein binding site [polypeptide binding]; other site 1171373005387 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1171373005388 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 1171373005389 Protein of unknown function DUF45; Region: DUF45; cl00636 1171373005390 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1171373005391 Part of AAA domain; Region: AAA_19; pfam13245 1171373005392 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1171373005393 Family description; Region: UvrD_C_2; pfam13538 1171373005394 HRDC domain; Region: HRDC; pfam00570 1171373005395 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 1171373005396 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 1171373005397 Part of AAA domain; Region: AAA_19; pfam13245 1171373005398 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 1171373005399 Family description; Region: UvrD_C_2; pfam13538 1171373005400 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1171373005401 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 1171373005402 AAA domain; Region: AAA_30; pfam13604 1171373005403 Family description; Region: UvrD_C_2; pfam13538 1171373005404 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1171373005405 Part of AAA domain; Region: AAA_19; pfam13245 1171373005406 Family description; Region: UvrD_C_2; pfam13538 1171373005407 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1171373005408 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1171373005409 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1171373005410 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1171373005411 DNA-binding site [nucleotide binding]; DNA binding site 1171373005412 RNA-binding motif; other site 1171373005413 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 1171373005414 active site 1171373005415 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 1171373005416 tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like; Region: MiaE_2; pfam13794 1171373005417 helicase 45; Provisional; Region: PTZ00424 1171373005418 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1171373005419 ATP binding site [chemical binding]; other site 1171373005420 Mg++ binding site [ion binding]; other site 1171373005421 motif III; other site 1171373005422 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1171373005423 nucleotide binding region [chemical binding]; other site 1171373005424 ATP-binding site [chemical binding]; other site 1171373005425 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1171373005426 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1171373005427 active site 1171373005428 HIGH motif; other site 1171373005429 dimer interface [polypeptide binding]; other site 1171373005430 KMSKS motif; other site 1171373005431 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1171373005432 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 1171373005433 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1171373005434 active site 1171373005435 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1171373005436 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 1171373005437 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1171373005438 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1171373005439 SEC-C motif; Region: SEC-C; pfam02810 1171373005440 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 1171373005441 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1171373005442 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1171373005443 30S subunit binding site; other site 1171373005444 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1171373005445 active site 1171373005446 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 1171373005447 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1171373005448 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1171373005449 dimerization interface [polypeptide binding]; other site 1171373005450 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1171373005451 dimer interface [polypeptide binding]; other site 1171373005452 phosphorylation site [posttranslational modification] 1171373005453 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1171373005454 ATP binding site [chemical binding]; other site 1171373005455 Mg2+ binding site [ion binding]; other site 1171373005456 G-X-G motif; other site 1171373005457 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1171373005458 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1171373005459 active site 1171373005460 phosphorylation site [posttranslational modification] 1171373005461 intermolecular recognition site; other site 1171373005462 dimerization interface [polypeptide binding]; other site 1171373005463 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1171373005464 DNA binding site [nucleotide binding] 1171373005465 hypothetical protein; Validated; Region: PRK00228 1171373005466 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1171373005467 Tic20-like protein; Region: Tic20; pfam09685 1171373005468 argininosuccinate lyase; Provisional; Region: PRK00855 1171373005469 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1171373005470 active sites [active] 1171373005471 tetramer interface [polypeptide binding]; other site 1171373005472 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1171373005473 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1171373005474 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1171373005475 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 1171373005476 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1171373005477 inhibitor-cofactor binding pocket; inhibition site 1171373005478 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1171373005479 catalytic residue [active] 1171373005480 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 1171373005481 feedback inhibition sensing region; other site 1171373005482 homohexameric interface [polypeptide binding]; other site 1171373005483 nucleotide binding site [chemical binding]; other site 1171373005484 N-acetyl-L-glutamate binding site [chemical binding]; other site 1171373005485 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1171373005486 heterotetramer interface [polypeptide binding]; other site 1171373005487 active site pocket [active] 1171373005488 cleavage site 1171373005489 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1171373005490 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1171373005491 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1171373005492 SmpB-tmRNA interface; other site 1171373005493 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1171373005494 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1171373005495 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1171373005496 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1171373005497 Walker A/P-loop; other site 1171373005498 ATP binding site [chemical binding]; other site 1171373005499 Q-loop/lid; other site 1171373005500 ABC transporter signature motif; other site 1171373005501 Walker B; other site 1171373005502 D-loop; other site 1171373005503 H-loop/switch region; other site 1171373005504 peptide chain release factor 2; Validated; Region: prfB; PRK00578 1171373005505 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1171373005506 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1171373005507 RF-1 domain; Region: RF-1; pfam00472 1171373005508 Protein of unknown function (DUF805); Region: DUF805; pfam05656 1171373005509 Protein of unknown function (DUF805); Region: DUF805; pfam05656 1171373005510 Protein of unknown function (DUF805); Region: DUF805; pfam05656 1171373005511 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1171373005512 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1171373005513 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1171373005514 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1171373005515 thiamine monophosphate kinase; Provisional; Region: PRK05731 1171373005516 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1171373005517 ATP binding site [chemical binding]; other site 1171373005518 dimerization interface [polypeptide binding]; other site 1171373005519 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1171373005520 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1171373005521 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1171373005522 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1171373005523 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1171373005524 putative acyl-acceptor binding pocket; other site 1171373005525 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1171373005526 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1171373005527 substrate binding site [chemical binding]; other site 1171373005528 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1171373005529 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1171373005530 substrate binding site [chemical binding]; other site 1171373005531 ligand binding site [chemical binding]; other site 1171373005532 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1171373005533 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 1171373005534 Bacterial transcriptional regulator; Region: IclR; pfam01614 1171373005535 CAAX protease self-immunity; Region: Abi; pfam02517 1171373005536 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 1171373005537 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1171373005538 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1171373005539 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 1171373005540 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1171373005541 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1171373005542 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 1171373005543 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 1171373005544 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 1171373005545 active site 1171373005546 catalytic residues [active] 1171373005547 metal binding site [ion binding]; metal-binding site 1171373005548 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 1171373005549 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1171373005550 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1171373005551 homodimer interface [polypeptide binding]; other site 1171373005552 substrate-cofactor binding pocket; other site 1171373005553 catalytic residue [active] 1171373005554 tartrate dehydrogenase; Region: TTC; TIGR02089 1171373005555 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 1171373005556 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 1171373005557 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1171373005558 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1171373005559 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1171373005560 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1171373005561 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1171373005562 putative valine binding site [chemical binding]; other site 1171373005563 dimer interface [polypeptide binding]; other site 1171373005564 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1171373005565 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 1171373005566 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1171373005567 PYR/PP interface [polypeptide binding]; other site 1171373005568 dimer interface [polypeptide binding]; other site 1171373005569 TPP binding site [chemical binding]; other site 1171373005570 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1171373005571 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1171373005572 TPP-binding site [chemical binding]; other site 1171373005573 dimer interface [polypeptide binding]; other site 1171373005574 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1171373005575 HIT family signature motif; other site 1171373005576 catalytic residue [active] 1171373005577 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1171373005578 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1171373005579 substrate binding site [chemical binding]; other site 1171373005580 glutamase interaction surface [polypeptide binding]; other site 1171373005581 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1171373005582 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1171373005583 ATP binding site [chemical binding]; other site 1171373005584 putative Mg++ binding site [ion binding]; other site 1171373005585 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1171373005586 nucleotide binding region [chemical binding]; other site 1171373005587 ATP-binding site [chemical binding]; other site 1171373005588 rRNA-processing arch domain; Region: rRNA_proc-arch; pfam13234 1171373005589 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 1171373005590 putative lipid kinase; Reviewed; Region: PRK13057 1171373005591 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1171373005592 Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902 1171373005593 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 1171373005594 Predicted transcriptional regulator [Transcription]; Region: COG2378 1171373005595 WYL domain; Region: WYL; pfam13280 1171373005596 Predicted transcriptional regulator [Transcription]; Region: COG2378 1171373005597 WYL domain; Region: WYL; pfam13280 1171373005598 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 1171373005599 active site 1171373005600 HIGH motif; other site 1171373005601 nucleotide binding site [chemical binding]; other site 1171373005602 active site 1171373005603 KMSKS motif; other site 1171373005604 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1171373005605 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1171373005606 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1171373005607 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1171373005608 RNA binding surface [nucleotide binding]; other site 1171373005609 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1171373005610 active site 1171373005611 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1171373005612 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1171373005613 P-loop; other site 1171373005614 Magnesium ion binding site [ion binding]; other site 1171373005615 transport-energizing ATPase, TRC40/GET3/ArsA family; Region: GET3_arsA_TRC40; TIGR00345 1171373005616 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1171373005617 Magnesium ion binding site [ion binding]; other site 1171373005618 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1171373005619 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1171373005620 active site 1171373005621 DNA binding site [nucleotide binding] 1171373005622 Int/Topo IB signature motif; other site 1171373005623 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1171373005624 dimer interface [polypeptide binding]; other site 1171373005625 ADP-ribose binding site [chemical binding]; other site 1171373005626 active site 1171373005627 nudix motif; other site 1171373005628 metal binding site [ion binding]; metal-binding site 1171373005629 CTP synthetase; Validated; Region: pyrG; PRK05380 1171373005630 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1171373005631 Catalytic site [active] 1171373005632 active site 1171373005633 UTP binding site [chemical binding]; other site 1171373005634 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1171373005635 active site 1171373005636 putative oxyanion hole; other site 1171373005637 catalytic triad [active] 1171373005638 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1171373005639 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1171373005640 Walker A/P-loop; other site 1171373005641 ATP binding site [chemical binding]; other site 1171373005642 Q-loop/lid; other site 1171373005643 ABC transporter signature motif; other site 1171373005644 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1171373005645 ABC transporter signature motif; other site 1171373005646 Walker B; other site 1171373005647 D-loop; other site 1171373005648 H-loop/switch region; other site 1171373005649 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 1171373005650 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1171373005651 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1171373005652 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1171373005653 RNA binding surface [nucleotide binding]; other site 1171373005654 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1171373005655 S-adenosylmethionine binding site [chemical binding]; other site 1171373005656 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1171373005657 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1171373005658 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1171373005659 Walker A/P-loop; other site 1171373005660 ATP binding site [chemical binding]; other site 1171373005661 Q-loop/lid; other site 1171373005662 ABC transporter signature motif; other site 1171373005663 Walker B; other site 1171373005664 D-loop; other site 1171373005665 H-loop/switch region; other site 1171373005666 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1171373005667 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1171373005668 active site 1171373005669 motif I; other site 1171373005670 motif II; other site 1171373005671 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1171373005672 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 1171373005673 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 1171373005674 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 1171373005675 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 1171373005676 homodimer interface [polypeptide binding]; other site 1171373005677 putative metal binding site [ion binding]; other site 1171373005678 Nicotinamide mononucleotide transporter [Coenzyme metabolism]; Region: PnuC; COG3201 1171373005679 Protein of unknown function (DUF3090); Region: DUF3090; cl12832 1171373005680 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1171373005681 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1171373005682 active site 1171373005683 catalytic tetrad [active] 1171373005684 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1171373005685 dimer interface [polypeptide binding]; other site 1171373005686 Citrate synthase; Region: Citrate_synt; pfam00285 1171373005687 active site 1171373005688 citrylCoA binding site [chemical binding]; other site 1171373005689 NADH binding [chemical binding]; other site 1171373005690 cationic pore residues; other site 1171373005691 oxalacetate/citrate binding site [chemical binding]; other site 1171373005692 coenzyme A binding site [chemical binding]; other site 1171373005693 catalytic triad [active] 1171373005694 hypothetical protein; Provisional; Region: PRK07906 1171373005695 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 1171373005696 putative metal binding site [ion binding]; other site 1171373005697 Integrase core domain; Region: rve; pfam00665 1171373005698 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1171373005699 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1171373005700 Winged helix-turn helix; Region: HTH_29; pfam13551 1171373005701 Homeodomain-like domain; Region: HTH_32; pfam13565 1171373005702 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1171373005703 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1171373005704 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1171373005705 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1171373005706 DNA binding site [nucleotide binding] 1171373005707 domain linker motif; other site 1171373005708 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 1171373005709 ligand binding site [chemical binding]; other site 1171373005710 dimerization interface (open form) [polypeptide binding]; other site 1171373005711 dimerization interface (closed form) [polypeptide binding]; other site 1171373005712 L-arabinose isomerase; Provisional; Region: PRK02929 1171373005713 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 1171373005714 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1171373005715 trimer interface [polypeptide binding]; other site 1171373005716 substrate binding site [chemical binding]; other site 1171373005717 Mn binding site [ion binding]; other site 1171373005718 L-ribulose-5-phosphate 4-epimerase; Validated; Region: PRK06557 1171373005719 intersubunit interface [polypeptide binding]; other site 1171373005720 active site 1171373005721 Zn2+ binding site [ion binding]; other site 1171373005722 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1171373005723 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1171373005724 putative substrate translocation pore; other site 1171373005725 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1171373005726 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1171373005727 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1171373005728 DNA binding site [nucleotide binding] 1171373005729 domain linker motif; other site 1171373005730 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1171373005731 dimerization interface [polypeptide binding]; other site 1171373005732 ligand binding site [chemical binding]; other site 1171373005733 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1171373005734 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1171373005735 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 1171373005736 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 1171373005737 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1171373005738 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1171373005739 DNA binding site [nucleotide binding] 1171373005740 domain linker motif; other site 1171373005741 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1171373005742 dimerization interface [polypeptide binding]; other site 1171373005743 ligand binding site [chemical binding]; other site 1171373005744 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1171373005745 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1171373005746 dimer interface [polypeptide binding]; other site 1171373005747 conserved gate region; other site 1171373005748 putative PBP binding loops; other site 1171373005749 ABC-ATPase subunit interface; other site 1171373005750 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1171373005751 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1171373005752 dimer interface [polypeptide binding]; other site 1171373005753 conserved gate region; other site 1171373005754 putative PBP binding loops; other site 1171373005755 ABC-ATPase subunit interface; other site 1171373005756 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1171373005757 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 1171373005758 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 1171373005759 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1171373005760 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1171373005761 nucleotide binding site [chemical binding]; other site 1171373005762 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1171373005763 DNA protecting protein DprA; Region: dprA; TIGR00732 1171373005764 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1171373005765 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1171373005766 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1171373005767 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1171373005768 hypothetical protein; Reviewed; Region: PRK12497 1171373005769 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 1171373005770 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1171373005771 RNA/DNA hybrid binding site [nucleotide binding]; other site 1171373005772 active site 1171373005773 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1171373005774 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1171373005775 Catalytic site [active] 1171373005776 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1171373005777 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 1171373005778 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1171373005779 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1171373005780 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 1171373005781 L-aspartate oxidase; Provisional; Region: PRK06175 1171373005782 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1171373005783 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 1171373005784 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 1171373005785 putative Iron-sulfur protein interface [polypeptide binding]; other site 1171373005786 proximal heme binding site [chemical binding]; other site 1171373005787 distal heme binding site [chemical binding]; other site 1171373005788 putative dimer interface [polypeptide binding]; other site 1171373005789 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1171373005790 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1171373005791 RimM N-terminal domain; Region: RimM; pfam01782 1171373005792 PRC-barrel domain; Region: PRC; pfam05239 1171373005793 hypothetical protein; Provisional; Region: PRK02821 1171373005794 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1171373005795 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 1171373005796 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1171373005797 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1171373005798 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1171373005799 active site 1171373005800 signal recognition particle protein; Provisional; Region: PRK10867 1171373005801 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1171373005802 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1171373005803 P loop; other site 1171373005804 GTP binding site [chemical binding]; other site 1171373005805 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1171373005806 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 1171373005807 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1171373005808 EamA-like transporter family; Region: EamA; cl17759 1171373005809 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 1171373005810 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1171373005811 Ligand binding site; other site 1171373005812 Putative Catalytic site; other site 1171373005813 DXD motif; other site 1171373005814 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1171373005815 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1171373005816 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1171373005817 P loop; other site 1171373005818 GTP binding site [chemical binding]; other site 1171373005819 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1171373005820 Predicted membrane protein [Function unknown]; Region: COG2246 1171373005821 GtrA-like protein; Region: GtrA; pfam04138 1171373005822 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1171373005823 salt bridge; other site 1171373005824 non-specific DNA binding site [nucleotide binding]; other site 1171373005825 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1171373005826 sequence-specific DNA binding site [nucleotide binding]; other site 1171373005827 Uncharacterized protein conserved in bacteria (DUF2255); Region: DUF2255; pfam10012 1171373005828 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 1171373005829 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1171373005830 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1171373005831 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1171373005832 active site 1171373005833 catalytic tetrad [active] 1171373005834 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1171373005835 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1171373005836 DNA binding site [nucleotide binding] 1171373005837 catalytic residue [active] 1171373005838 H2TH interface [polypeptide binding]; other site 1171373005839 putative catalytic residues [active] 1171373005840 turnover-facilitating residue; other site 1171373005841 intercalation triad [nucleotide binding]; other site 1171373005842 8OG recognition residue [nucleotide binding]; other site 1171373005843 putative reading head residues; other site 1171373005844 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1171373005845 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1171373005846 ribonuclease III; Reviewed; Region: rnc; PRK00102 1171373005847 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1171373005848 dimerization interface [polypeptide binding]; other site 1171373005849 active site 1171373005850 metal binding site [ion binding]; metal-binding site 1171373005851 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1171373005852 dsRNA binding site [nucleotide binding]; other site 1171373005853 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 1171373005854 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 1171373005855 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1171373005856 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1171373005857 active site 1171373005858 (T/H)XGH motif; other site 1171373005859 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1171373005860 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1171373005861 S-adenosylmethionine binding site [chemical binding]; other site 1171373005862 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 1171373005863 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1171373005864 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1171373005865 ssDNA binding site; other site 1171373005866 generic binding surface II; other site 1171373005867 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1171373005868 ATP binding site [chemical binding]; other site 1171373005869 putative Mg++ binding site [ion binding]; other site 1171373005870 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1171373005871 nucleotide binding region [chemical binding]; other site 1171373005872 ATP-binding site [chemical binding]; other site 1171373005873 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 1171373005874 putative deacylase active site [active] 1171373005875 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1171373005876 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1171373005877 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1171373005878 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1171373005879 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1171373005880 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1171373005881 Coenzyme A binding pocket [chemical binding]; other site 1171373005882 pyruvate dehydrogenase; Provisional; Region: PRK06546 1171373005883 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1171373005884 PYR/PP interface [polypeptide binding]; other site 1171373005885 dimer interface [polypeptide binding]; other site 1171373005886 tetramer interface [polypeptide binding]; other site 1171373005887 TPP binding site [chemical binding]; other site 1171373005888 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1171373005889 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1171373005890 TPP-binding site [chemical binding]; other site 1171373005891 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1171373005892 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1171373005893 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1171373005894 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1171373005895 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 1171373005896 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 1171373005897 oligomer interface [polypeptide binding]; other site 1171373005898 RNA binding site [nucleotide binding]; other site 1171373005899 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1171373005900 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1171373005901 RNase E interface [polypeptide binding]; other site 1171373005902 trimer interface [polypeptide binding]; other site 1171373005903 active site 1171373005904 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1171373005905 putative nucleic acid binding region [nucleotide binding]; other site 1171373005906 G-X-X-G motif; other site 1171373005907 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1171373005908 RNA binding site [nucleotide binding]; other site 1171373005909 domain interface; other site 1171373005910 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1171373005911 16S/18S rRNA binding site [nucleotide binding]; other site 1171373005912 S13e-L30e interaction site [polypeptide binding]; other site 1171373005913 25S rRNA binding site [nucleotide binding]; other site 1171373005914 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1171373005915 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1171373005916 active site 1171373005917 Riboflavin kinase; Region: Flavokinase; smart00904 1171373005918 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1171373005919 active site 1171373005920 NTP binding site [chemical binding]; other site 1171373005921 metal binding triad [ion binding]; metal-binding site 1171373005922 antibiotic binding site [chemical binding]; other site 1171373005923 Protein of unknown function DUF86; Region: DUF86; cl01031 1171373005924 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 1171373005925 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1171373005926 RNA binding site [nucleotide binding]; other site 1171373005927 active site 1171373005928 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 1171373005929 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 1171373005930 PRD domain; Region: PRD; pfam00874 1171373005931 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359 1171373005932 active site 1171373005933 phosphorylation site [posttranslational modification] 1171373005934 Glucitol operon activator protein (GutM); Region: GutM; pfam06923 1171373005935 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; pfam03608 1171373005936 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 1171373005937 PTS system, glucitol/sorbitol-specific, IIBC component; Region: EIIBC-GUT; TIGR00825 1171373005938 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 1171373005939 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829 1171373005940 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1171373005941 dimerization domain swap beta strand [polypeptide binding]; other site 1171373005942 regulatory protein interface [polypeptide binding]; other site 1171373005943 active site 1171373005944 regulatory phosphorylation site [posttranslational modification]; other site 1171373005945 Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175 1171373005946 active site 1171373005947 metal binding site [ion binding]; metal-binding site 1171373005948 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1171373005949 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1171373005950 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1171373005951 ABC1 family; Region: ABC1; cl17513 1171373005952 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1171373005953 active site 1171373005954 ATP binding site [chemical binding]; other site 1171373005955 substrate binding site [chemical binding]; other site 1171373005956 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1171373005957 translation initiation factor IF-2; Region: IF-2; TIGR00487 1171373005958 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1171373005959 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1171373005960 G1 box; other site 1171373005961 putative GEF interaction site [polypeptide binding]; other site 1171373005962 GTP/Mg2+ binding site [chemical binding]; other site 1171373005963 Switch I region; other site 1171373005964 G2 box; other site 1171373005965 G3 box; other site 1171373005966 Switch II region; other site 1171373005967 G4 box; other site 1171373005968 G5 box; other site 1171373005969 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1171373005970 Translation-initiation factor 2; Region: IF-2; pfam11987 1171373005971 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1171373005972 Protein of unknown function (DUF448); Region: DUF448; pfam04296 1171373005973 putative RNA binding cleft [nucleotide binding]; other site 1171373005974 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1171373005975 NusA N-terminal domain; Region: NusA_N; pfam08529 1171373005976 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1171373005977 RNA binding site [nucleotide binding]; other site 1171373005978 homodimer interface [polypeptide binding]; other site 1171373005979 NusA-like KH domain; Region: KH_5; pfam13184 1171373005980 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1171373005981 G-X-X-G motif; other site 1171373005982 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1171373005983 Sm and related proteins; Region: Sm_like; cl00259 1171373005984 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1171373005985 putative oligomer interface [polypeptide binding]; other site 1171373005986 putative RNA binding site [nucleotide binding]; other site 1171373005987 hypothetical protein; Provisional; Region: PRK10621 1171373005988 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1171373005989 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 1171373005990 CGNR zinc finger; Region: zf-CGNR; pfam11706 1171373005991 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1171373005992 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1171373005993 dimer interface [polypeptide binding]; other site 1171373005994 motif 1; other site 1171373005995 active site 1171373005996 motif 2; other site 1171373005997 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1171373005998 putative deacylase active site [active] 1171373005999 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1171373006000 active site 1171373006001 motif 3; other site 1171373006002 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1171373006003 anticodon binding site; other site 1171373006004 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1171373006005 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1171373006006 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1171373006007 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 1171373006008 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 1171373006009 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 1171373006010 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1171373006011 multicopper oxidase; Provisional; Region: PRK10965 1171373006012 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1171373006013 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1171373006014 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 1171373006015 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1171373006016 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1171373006017 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1171373006018 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1171373006019 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1171373006020 RIP metalloprotease RseP; Region: TIGR00054 1171373006021 active site 1171373006022 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1171373006023 protein binding site [polypeptide binding]; other site 1171373006024 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1171373006025 Beta-lactamase; Region: Beta-lactamase; pfam00144 1171373006026 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1171373006027 glutamate dehydrogenase; Provisional; Region: PRK09414 1171373006028 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1171373006029 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 1171373006030 NAD(P) binding site [chemical binding]; other site 1171373006031 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 1171373006032 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1171373006033 FeS/SAM binding site; other site 1171373006034 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1171373006035 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1171373006036 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1171373006037 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1171373006038 hinge region; other site 1171373006039 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1171373006040 putative nucleotide binding site [chemical binding]; other site 1171373006041 uridine monophosphate binding site [chemical binding]; other site 1171373006042 homohexameric interface [polypeptide binding]; other site 1171373006043 elongation factor Ts; Provisional; Region: tsf; PRK09377 1171373006044 UBA/TS-N domain; Region: UBA; pfam00627 1171373006045 Elongation factor TS; Region: EF_TS; pfam00889 1171373006046 Elongation factor TS; Region: EF_TS; pfam00889 1171373006047 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1171373006048 rRNA interaction site [nucleotide binding]; other site 1171373006049 S8 interaction site; other site 1171373006050 putative laminin-1 binding site; other site 1171373006051 Integrase core domain; Region: rve; pfam00665 1171373006052 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1171373006053 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 1171373006054 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 1171373006055 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 1171373006056 metal ion-dependent adhesion site (MIDAS); other site 1171373006057 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1171373006058 Peptidase family M23; Region: Peptidase_M23; pfam01551 1171373006059 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1171373006060 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1171373006061 active site 1171373006062 DNA binding site [nucleotide binding] 1171373006063 Int/Topo IB signature motif; other site 1171373006064 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 1171373006065 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1171373006066 active site 1171373006067 catalytic residues [active] 1171373006068 metal binding site [ion binding]; metal-binding site 1171373006069 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1171373006070 sequence-specific DNA binding site [nucleotide binding]; other site 1171373006071 salt bridge; other site 1171373006072 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 1171373006073 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1171373006074 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1171373006075 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 1171373006076 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1171373006077 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1171373006078 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1171373006079 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 1171373006080 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1171373006081 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1171373006082 Walker A/P-loop; other site 1171373006083 ATP binding site [chemical binding]; other site 1171373006084 ABC transporter signature motif; other site 1171373006085 Walker B; other site 1171373006086 D-loop; other site 1171373006087 H-loop/switch region; other site 1171373006088 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1171373006089 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1171373006090 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1171373006091 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1171373006092 Aspartase; Region: Aspartase; cd01357 1171373006093 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1171373006094 active sites [active] 1171373006095 tetramer interface [polypeptide binding]; other site 1171373006096 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1171373006097 active site 1171373006098 ATP binding site [chemical binding]; other site 1171373006099 substrate binding site [chemical binding]; other site 1171373006100 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 1171373006101 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1171373006102 NAD(P) binding site [chemical binding]; other site 1171373006103 active site 1171373006104 acetoacetyl-CoA reductase; Provisional; Region: PRK12824 1171373006105 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1171373006106 NAD(P) binding site [chemical binding]; other site 1171373006107 active site 1171373006108 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 1171373006109 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 1171373006110 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1171373006111 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1171373006112 NAD(P) binding site [chemical binding]; other site 1171373006113 active site 1171373006114 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 1171373006115 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1171373006116 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1171373006117 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1171373006118 Walker A/P-loop; other site 1171373006119 ATP binding site [chemical binding]; other site 1171373006120 Q-loop/lid; other site 1171373006121 ABC transporter signature motif; other site 1171373006122 Walker B; other site 1171373006123 D-loop; other site 1171373006124 H-loop/switch region; other site 1171373006125 ABC transporter; Region: ABC_tran_2; pfam12848 1171373006126 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1171373006127 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1171373006128 Coenzyme A binding pocket [chemical binding]; other site 1171373006129 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1171373006130 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1171373006131 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1171373006132 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1171373006133 trimerization site [polypeptide binding]; other site 1171373006134 active site 1171373006135 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1171373006136 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1171373006137 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1171373006138 catalytic residue [active] 1171373006139 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1171373006140 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1171373006141 Walker A/P-loop; other site 1171373006142 ATP binding site [chemical binding]; other site 1171373006143 Q-loop/lid; other site 1171373006144 ABC transporter signature motif; other site 1171373006145 Walker B; other site 1171373006146 D-loop; other site 1171373006147 H-loop/switch region; other site 1171373006148 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 1171373006149 [2Fe-2S] cluster binding site [ion binding]; other site 1171373006150 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1171373006151 FeS assembly protein SufD; Region: sufD; TIGR01981 1171373006152 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1171373006153 FeS assembly protein SufB; Region: sufB; TIGR01980 1171373006154 Predicted transcriptional regulator [Transcription]; Region: COG2345 1171373006155 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1171373006156 putative Zn2+ binding site [ion binding]; other site 1171373006157 putative DNA binding site [nucleotide binding]; other site 1171373006158 Integrase core domain; Region: rve; pfam00665 1171373006159 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1171373006160 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1171373006161 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1171373006162 dimer interface [polypeptide binding]; other site 1171373006163 conserved gate region; other site 1171373006164 putative PBP binding loops; other site 1171373006165 ABC-ATPase subunit interface; other site 1171373006166 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1171373006167 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1171373006168 dimer interface [polypeptide binding]; other site 1171373006169 conserved gate region; other site 1171373006170 putative PBP binding loops; other site 1171373006171 ABC-ATPase subunit interface; other site 1171373006172 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1171373006173 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1171373006174 DNA binding site [nucleotide binding] 1171373006175 domain linker motif; other site 1171373006176 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1171373006177 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1171373006178 MULE transposase domain; Region: MULE; pfam10551 1171373006179 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1171373006180 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1171373006181 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 1171373006182 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 1171373006183 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1171373006184 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1171373006185 Walker A/P-loop; other site 1171373006186 ATP binding site [chemical binding]; other site 1171373006187 Q-loop/lid; other site 1171373006188 ABC transporter signature motif; other site 1171373006189 Walker B; other site 1171373006190 D-loop; other site 1171373006191 H-loop/switch region; other site 1171373006192 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1171373006193 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1171373006194 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1171373006195 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1171373006196 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1171373006197 UbiA prenyltransferase family; Region: UbiA; pfam01040 1171373006198 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1171373006199 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1171373006200 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1171373006201 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 1171373006202 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 1171373006203 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1171373006204 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 1171373006205 putative active site [active] 1171373006206 Thioredoxin; Region: Thioredoxin_4; cl17273 1171373006207 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208 1171373006208 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1171373006209 active site 1171373006210 HIGH motif; other site 1171373006211 nucleotide binding site [chemical binding]; other site 1171373006212 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1171373006213 active site 1171373006214 KMSKS motif; other site 1171373006215 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1171373006216 tRNA binding surface [nucleotide binding]; other site 1171373006217 anticodon binding site; other site 1171373006218 AAA domain; Region: AAA_17; pfam13207 1171373006219 Protein of unknown function (DUF664); Region: DUF664; pfam04978 1171373006220 DinB superfamily; Region: DinB_2; pfam12867 1171373006221 Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown]; Region: COG4946 1171373006222 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1171373006223 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 1171373006224 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1171373006225 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1171373006226 protein binding site [polypeptide binding]; other site 1171373006227 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 1171373006228 Domain interface; other site 1171373006229 Peptide binding site; other site 1171373006230 Active site tetrad [active] 1171373006231 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1171373006232 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1171373006233 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1171373006234 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1171373006235 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1171373006236 Walker A motif; other site 1171373006237 ATP binding site [chemical binding]; other site 1171373006238 Walker B motif; other site 1171373006239 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1171373006240 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 1171373006241 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1171373006242 oligomer interface [polypeptide binding]; other site 1171373006243 active site residues [active] 1171373006244 Clp protease; Region: CLP_protease; pfam00574 1171373006245 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1171373006246 oligomer interface [polypeptide binding]; other site 1171373006247 active site residues [active] 1171373006248 Herpes DNA replication accessory factor; Region: Herpes_DNAp_acc; pfam04929 1171373006249 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1171373006250 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1171373006251 trigger factor; Provisional; Region: tig; PRK01490 1171373006252 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1171373006253 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1171373006254 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1171373006255 active site 1171373006256 Int/Topo IB signature motif; other site 1171373006257 putative transposase OrfB; Reviewed; Region: PHA02517 1171373006258 HTH-like domain; Region: HTH_21; pfam13276 1171373006259 Integrase core domain; Region: rve; pfam00665 1171373006260 Integrase core domain; Region: rve_3; pfam13683 1171373006261 Divergent AAA domain; Region: AAA_4; pfam04326 1171373006262 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 1171373006263 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1171373006264 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 1171373006265 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1171373006266 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1171373006267 MULE transposase domain; Region: MULE; pfam10551 1171373006268 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1171373006269 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1171373006270 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1171373006271 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1171373006272 BsuBI/PstI restriction endonuclease C-terminus; Region: BsuBI_PstI_RE; pfam06616 1171373006273 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1171373006274 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1171373006275 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1171373006276 catalytic site [active] 1171373006277 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 1171373006278 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1171373006279 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1171373006280 dimer interface [polypeptide binding]; other site 1171373006281 putative anticodon binding site; other site 1171373006282 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1171373006283 motif 1; other site 1171373006284 dimer interface [polypeptide binding]; other site 1171373006285 active site 1171373006286 motif 2; other site 1171373006287 motif 3; other site 1171373006288 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1171373006289 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 1171373006290 putative DNA binding site [nucleotide binding]; other site 1171373006291 catalytic residue [active] 1171373006292 putative H2TH interface [polypeptide binding]; other site 1171373006293 putative catalytic residues [active] 1171373006294 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1171373006295 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1171373006296 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 1171373006297 hypothetical protein; Provisional; Region: PRK01346 1171373006298 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 1171373006299 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1171373006300 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1171373006301 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1171373006302 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1171373006303 nucleotide binding pocket [chemical binding]; other site 1171373006304 K-X-D-G motif; other site 1171373006305 catalytic site [active] 1171373006306 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1171373006307 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1171373006308 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1171373006309 Dimer interface [polypeptide binding]; other site 1171373006310 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1171373006311 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 1171373006312 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 1171373006313 Zn binding site [ion binding]; other site 1171373006314 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1171373006315 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1171373006316 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1171373006317 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1171373006318 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1171373006319 Coenzyme A binding pocket [chemical binding]; other site 1171373006320 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1171373006321 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1171373006322 putative substrate translocation pore; other site 1171373006323 MarR family; Region: MarR_2; cl17246 1171373006324 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1171373006325 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1171373006326 active site 1171373006327 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1171373006328 active site 1171373006329 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1171373006330 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1171373006331 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1171373006332 acyl-activating enzyme (AAE) consensus motif; other site 1171373006333 putative AMP binding site [chemical binding]; other site 1171373006334 putative active site [active] 1171373006335 putative CoA binding site [chemical binding]; other site 1171373006336 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1171373006337 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1171373006338 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1171373006339 acyl-activating enzyme (AAE) consensus motif; other site 1171373006340 putative AMP binding site [chemical binding]; other site 1171373006341 putative active site [active] 1171373006342 putative CoA binding site [chemical binding]; other site 1171373006343 MarR family; Region: MarR_2; pfam12802 1171373006344 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1171373006345 FAD binding domain; Region: FAD_binding_4; pfam01565 1171373006346 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1171373006347 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1171373006348 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1171373006349 Walker A/P-loop; other site 1171373006350 ATP binding site [chemical binding]; other site 1171373006351 Q-loop/lid; other site 1171373006352 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1171373006353 ABC transporter; Region: ABC_tran_2; pfam12848 1171373006354 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1171373006355 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1171373006356 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1171373006357 dimer interface [polypeptide binding]; other site 1171373006358 ssDNA binding site [nucleotide binding]; other site 1171373006359 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1171373006360 Protease prsW family; Region: PrsW-protease; pfam13367 1171373006361 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1171373006362 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1171373006363 catalytic site [active] 1171373006364 putative active site [active] 1171373006365 putative substrate binding site [chemical binding]; other site 1171373006366 dimer interface [polypeptide binding]; other site 1171373006367 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 1171373006368 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1171373006369 S-adenosylmethionine binding site [chemical binding]; other site 1171373006370 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1171373006371 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 1171373006372 aspartate racemase; Region: asp_race; TIGR00035 1171373006373 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1171373006374 ATP-binding site [chemical binding]; other site 1171373006375 Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar6; cd09176 1171373006376 putative homodimer interface [polypeptide binding]; other site 1171373006377 putative active site [active] 1171373006378 catalytic site [active] 1171373006379 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1171373006380 active site 1171373006381 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1171373006382 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1171373006383 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1171373006384 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 1171373006385 NmrA-like family; Region: NmrA; pfam05368 1171373006386 NADP binding site [chemical binding]; other site 1171373006387 active site 1171373006388 regulatory binding site [polypeptide binding]; other site 1171373006389 Hemerythrin-like domain; Region: Hr-like; cd12108 1171373006390 Fe binding site [ion binding]; other site 1171373006391 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1171373006392 aspartate racemase; Region: asp_race; TIGR00035 1171373006393 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 1171373006394 putative deacylase active site [active] 1171373006395 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1171373006396 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1171373006397 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 1171373006398 trimer interface [polypeptide binding]; other site 1171373006399 active site 1171373006400 substrate binding site [chemical binding]; other site 1171373006401 CoA binding site [chemical binding]; other site 1171373006402 Protein of unknown function (DUF3175); Region: DUF3175; pfam11373 1171373006403 protein-L-isoaspartate O-methyltransferase; Provisional; Region: PRK13944 1171373006404 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1171373006405 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1171373006406 active site 1171373006407 phosphorylation site [posttranslational modification] 1171373006408 intermolecular recognition site; other site 1171373006409 dimerization interface [polypeptide binding]; other site 1171373006410 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1171373006411 DNA binding residues [nucleotide binding] 1171373006412 dimerization interface [polypeptide binding]; other site 1171373006413 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1171373006414 Histidine kinase; Region: HisKA_3; pfam07730 1171373006415 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1171373006416 ATP binding site [chemical binding]; other site 1171373006417 Mg2+ binding site [ion binding]; other site 1171373006418 G-X-G motif; other site 1171373006419 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1171373006420 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1171373006421 FtsX-like permease family; Region: FtsX; pfam02687 1171373006422 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1171373006423 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1171373006424 Walker A/P-loop; other site 1171373006425 ATP binding site [chemical binding]; other site 1171373006426 Q-loop/lid; other site 1171373006427 ABC transporter signature motif; other site 1171373006428 Walker B; other site 1171373006429 D-loop; other site 1171373006430 H-loop/switch region; other site 1171373006431 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 1171373006432 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1171373006433 FMN binding site [chemical binding]; other site 1171373006434 dimer interface [polypeptide binding]; other site 1171373006435 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1171373006436 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1171373006437 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 1171373006438 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1171373006439 Walker A/P-loop; other site 1171373006440 ATP binding site [chemical binding]; other site 1171373006441 Q-loop/lid; other site 1171373006442 ABC transporter signature motif; other site 1171373006443 Walker B; other site 1171373006444 D-loop; other site 1171373006445 H-loop/switch region; other site 1171373006446 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1171373006447 MarR family; Region: MarR_2; pfam12802 1171373006448 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353 1171373006449 putative dimer interface [polypeptide binding]; other site 1171373006450 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1171373006451 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 1171373006452 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1171373006453 Walker A/P-loop; other site 1171373006454 ATP binding site [chemical binding]; other site 1171373006455 Q-loop/lid; other site 1171373006456 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1171373006457 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1171373006458 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 1171373006459 Walker A/P-loop; other site 1171373006460 ATP binding site [chemical binding]; other site 1171373006461 Q-loop/lid; other site 1171373006462 ABC transporter signature motif; other site 1171373006463 Walker B; other site 1171373006464 D-loop; other site 1171373006465 H-loop/switch region; other site 1171373006466 amino acid transporter; Region: 2A0306; TIGR00909 1171373006467 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1171373006468 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1171373006469 dimer interface [polypeptide binding]; other site 1171373006470 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 1171373006471 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1171373006472 active site 1171373006473 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1171373006474 generic binding surface I; other site 1171373006475 generic binding surface II; other site 1171373006476 DNA Polymerase Y-family; Region: PolY_like; cd03468 1171373006477 active site 1171373006478 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 1171373006479 DNA binding site [nucleotide binding] 1171373006480 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 1171373006481 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 1171373006482 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1171373006483 catalytic triad [active] 1171373006484 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1171373006485 catalytic triad [active] 1171373006486 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1171373006487 oligomerisation interface [polypeptide binding]; other site 1171373006488 mobile loop; other site 1171373006489 roof hairpin; other site 1171373006490 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1171373006491 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1171373006492 catalytic triad [active] 1171373006493 RibD C-terminal domain; Region: RibD_C; cl17279 1171373006494 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1171373006495 DNA polymerase IV; Provisional; Region: PRK03348 1171373006496 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1171373006497 active site 1171373006498 DNA binding site [nucleotide binding] 1171373006499 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1171373006500 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1171373006501 folate binding site [chemical binding]; other site 1171373006502 NADP+ binding site [chemical binding]; other site 1171373006503 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1171373006504 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1171373006505 dimerization interface [polypeptide binding]; other site 1171373006506 active site 1171373006507 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1171373006508 active site 1171373006509 dimerization interface [polypeptide binding]; other site 1171373006510 ribonuclease PH; Reviewed; Region: rph; PRK00173 1171373006511 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1171373006512 hexamer interface [polypeptide binding]; other site 1171373006513 active site 1171373006514 glutamate racemase; Provisional; Region: PRK00865 1171373006515 RNA polymerase III subunit RPC82 helix-turn-helix domain; Region: HTH_9; pfam08221 1171373006516 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 1171373006517 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1171373006518 G1 box; other site 1171373006519 GTP/Mg2+ binding site [chemical binding]; other site 1171373006520 G2 box; other site 1171373006521 Switch I region; other site 1171373006522 G3 box; other site 1171373006523 Switch II region; other site 1171373006524 G4 box; other site 1171373006525 G5 box; other site 1171373006526 Nucleoside recognition; Region: Gate; pfam07670 1171373006527 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1171373006528 Nucleoside recognition; Region: Gate; pfam07670 1171373006529 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 1171373006530 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 1171373006531 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1171373006532 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1171373006533 active site 1171373006534 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1171373006535 IHF dimer interface [polypeptide binding]; other site 1171373006536 IHF - DNA interface [nucleotide binding]; other site 1171373006537 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 1171373006538 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 1171373006539 RDD family; Region: RDD; pfam06271 1171373006540 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 1171373006541 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1171373006542 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1171373006543 trimer interface [polypeptide binding]; other site 1171373006544 active site 1171373006545 dimer interface [polypeptide binding]; other site 1171373006546 Cation efflux family; Region: Cation_efflux; pfam01545 1171373006547 bifunctional phosphoglucose/phosphomannose isomerase; Validated; Region: PRK08674 1171373006548 Trm112p-like protein; Region: Trm112p; cl01066 1171373006549 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 1171373006550 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 1171373006551 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 1171373006552 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1171373006553 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1171373006554 active site 1171373006555 Transcription factor WhiB; Region: Whib; pfam02467 1171373006556 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1171373006557 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 1171373006558 Substrate binding site; other site 1171373006559 TIGR03089 family protein; Region: TIGR03089 1171373006560 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1171373006561 ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525 1171373006562 Ligand binding site; other site 1171373006563 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 1171373006564 AIR carboxylase; Region: AIRC; pfam00731 1171373006565 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1171373006566 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1171373006567 NAD binding site [chemical binding]; other site 1171373006568 ATP-grasp domain; Region: ATP-grasp; pfam02222 1171373006569 Bacterial PH domain; Region: DUF304; pfam03703 1171373006570 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 1171373006571 active site pocket [active] 1171373006572 oxyanion hole [active] 1171373006573 catalytic triad [active] 1171373006574 active site nucleophile [active] 1171373006575 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1171373006576 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1171373006577 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1171373006578 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1171373006579 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1171373006580 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1171373006581 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 1171373006582 Maf-like protein; Region: Maf; pfam02545 1171373006583 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1171373006584 active site 1171373006585 dimer interface [polypeptide binding]; other site 1171373006586 arginine deiminase; Provisional; Region: PRK01388 1171373006587 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1171373006588 short chain dehydrogenase; Provisional; Region: PRK08219 1171373006589 NAD(P) binding site [chemical binding]; other site 1171373006590 active site 1171373006591 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1171373006592 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1171373006593 dimer interface [polypeptide binding]; other site 1171373006594 substrate binding site [chemical binding]; other site 1171373006595 ATP binding site [chemical binding]; other site 1171373006596 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1171373006597 nudix motif; other site 1171373006598 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1171373006599 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1171373006600 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1171373006601 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1171373006602 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1171373006603 carboxyltransferase (CT) interaction site; other site 1171373006604 biotinylation site [posttranslational modification]; other site 1171373006605 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 1171373006606 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1171373006607 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1171373006608 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1171373006609 purine nucleoside phosphorylase; Provisional; Region: PRK08202 1171373006610 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 1171373006611 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1171373006612 active site 1171373006613 substrate binding site [chemical binding]; other site 1171373006614 metal binding site [ion binding]; metal-binding site 1171373006615 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1171373006616 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1171373006617 acyl-activating enzyme (AAE) consensus motif; other site 1171373006618 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1171373006619 AMP binding site [chemical binding]; other site 1171373006620 active site 1171373006621 acyl-activating enzyme (AAE) consensus motif; other site 1171373006622 CoA binding site [chemical binding]; other site 1171373006623 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 1171373006624 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 1171373006625 acetylornithine aminotransferase; Provisional; Region: PRK02627 1171373006626 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1171373006627 inhibitor-cofactor binding pocket; inhibition site 1171373006628 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1171373006629 catalytic residue [active] 1171373006630 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 1171373006631 Glycine/sarcosine/betaine reductase component B subunits; Region: Gly_reductase; pfam09338 1171373006632 glycine reductase, selenoprotein B; Region: gly_red_sel_B; TIGR01917 1171373006633 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1171373006634 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1171373006635 proline racemase; Provisional; Region: PRK13969 1171373006636 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 1171373006637 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1171373006638 active site 1171373006639 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 1171373006640 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1171373006641 active site 1171373006642 HIGH motif; other site 1171373006643 KMSKS motif; other site 1171373006644 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1171373006645 tRNA binding surface [nucleotide binding]; other site 1171373006646 anticodon binding site; other site 1171373006647 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1171373006648 RNA/DNA hybrid binding site [nucleotide binding]; other site 1171373006649 active site 1171373006650 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 1171373006651 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1171373006652 active site 1171373006653 catalytic motif [active] 1171373006654 Zn binding site [ion binding]; other site 1171373006655 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1171373006656 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1171373006657 TM-ABC transporter signature motif; other site 1171373006658 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1171373006659 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1171373006660 TM-ABC transporter signature motif; other site 1171373006661 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1171373006662 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1171373006663 Walker A/P-loop; other site 1171373006664 ATP binding site [chemical binding]; other site 1171373006665 Q-loop/lid; other site 1171373006666 ABC transporter signature motif; other site 1171373006667 Walker B; other site 1171373006668 D-loop; other site 1171373006669 H-loop/switch region; other site 1171373006670 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1171373006671 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1171373006672 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 1171373006673 ligand binding site [chemical binding]; other site 1171373006674 Phosphotransferase enzyme family; Region: APH; pfam01636 1171373006675 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1171373006676 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1171373006677 Domain of unknown function DUF21; Region: DUF21; pfam01595 1171373006678 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1171373006679 Transporter associated domain; Region: CorC_HlyC; smart01091 1171373006680 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1171373006681 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 1171373006682 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 1171373006683 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1171373006684 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1171373006685 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1171373006686 putative active site [active] 1171373006687 putative substrate binding site [chemical binding]; other site 1171373006688 putative cosubstrate binding site; other site 1171373006689 catalytic site [active] 1171373006690 malate dehydrogenase; Provisional; Region: PRK05442 1171373006691 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 1171373006692 NAD(P) binding site [chemical binding]; other site 1171373006693 dimer interface [polypeptide binding]; other site 1171373006694 malate binding site [chemical binding]; other site 1171373006695 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1171373006696 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 1171373006697 putative catalytic cysteine [active] 1171373006698 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 1171373006699 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 1171373006700 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1171373006701 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1171373006702 homodimer interface [polypeptide binding]; other site 1171373006703 NADP binding site [chemical binding]; other site 1171373006704 substrate binding site [chemical binding]; other site 1171373006705 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1171373006706 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1171373006707 purine monophosphate binding site [chemical binding]; other site 1171373006708 dimer interface [polypeptide binding]; other site 1171373006709 putative catalytic residues [active] 1171373006710 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1171373006711 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1171373006712 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1171373006713 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1171373006714 active site 1171373006715 cosubstrate binding site; other site 1171373006716 substrate binding site [chemical binding]; other site 1171373006717 catalytic site [active] 1171373006718 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1171373006719 homopentamer interface [polypeptide binding]; other site 1171373006720 active site 1171373006721 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1171373006722 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1171373006723 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1171373006724 dimerization interface [polypeptide binding]; other site 1171373006725 active site 1171373006726 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1171373006727 Lumazine binding domain; Region: Lum_binding; pfam00677 1171373006728 Lumazine binding domain; Region: Lum_binding; pfam00677 1171373006729 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1171373006730 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1171373006731 catalytic motif [active] 1171373006732 Zn binding site [ion binding]; other site 1171373006733 RibD C-terminal domain; Region: RibD_C; pfam01872 1171373006734 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1171373006735 CoA binding domain; Region: CoA_binding; smart00881 1171373006736 CoA-ligase; Region: Ligase_CoA; pfam00549 1171373006737 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1171373006738 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1171373006739 CoA-ligase; Region: Ligase_CoA; pfam00549 1171373006740 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1171373006741 Peptidase family M23; Region: Peptidase_M23; pfam01551 1171373006742 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1171373006743 Part of AAA domain; Region: AAA_19; pfam13245 1171373006744 Family description; Region: UvrD_C_2; pfam13538 1171373006745 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1171373006746 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1171373006747 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1171373006748 Walker A/P-loop; other site 1171373006749 ATP binding site [chemical binding]; other site 1171373006750 Q-loop/lid; other site 1171373006751 ABC transporter signature motif; other site 1171373006752 Walker B; other site 1171373006753 D-loop; other site 1171373006754 H-loop/switch region; other site 1171373006755 NIL domain; Region: NIL; cl09633 1171373006756 ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism]; Region: AbcD; COG2011 1171373006757 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1171373006758 PLD-like domain; Region: PLDc_2; pfam13091 1171373006759 putative active site [active] 1171373006760 catalytic site [active] 1171373006761 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1171373006762 PLD-like domain; Region: PLDc_2; pfam13091 1171373006763 putative active site [active] 1171373006764 catalytic site [active] 1171373006765 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 1171373006766 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1171373006767 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1171373006768 active site 1171373006769 phosphorylation site [posttranslational modification] 1171373006770 intermolecular recognition site; other site 1171373006771 dimerization interface [polypeptide binding]; other site 1171373006772 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1171373006773 DNA binding residues [nucleotide binding] 1171373006774 dimerization interface [polypeptide binding]; other site 1171373006775 PspC domain; Region: PspC; pfam04024 1171373006776 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1171373006777 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1171373006778 ATP binding site [chemical binding]; other site 1171373006779 Mg2+ binding site [ion binding]; other site 1171373006780 G-X-G motif; other site 1171373006781 PspC domain; Region: PspC; pfam04024 1171373006782 GMP synthase; Reviewed; Region: guaA; PRK00074 1171373006783 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1171373006784 AMP/PPi binding site [chemical binding]; other site 1171373006785 candidate oxyanion hole; other site 1171373006786 catalytic triad [active] 1171373006787 potential glutamine specificity residues [chemical binding]; other site 1171373006788 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1171373006789 ATP Binding subdomain [chemical binding]; other site 1171373006790 Ligand Binding sites [chemical binding]; other site 1171373006791 Dimerization subdomain; other site 1171373006792 serine O-acetyltransferase; Region: cysE; TIGR01172 1171373006793 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1171373006794 trimer interface [polypeptide binding]; other site 1171373006795 active site 1171373006796 substrate binding site [chemical binding]; other site 1171373006797 CoA binding site [chemical binding]; other site 1171373006798 chorismate mutase; Provisional; Region: PRK09239 1171373006799 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 1171373006800 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1171373006801 active site 1171373006802 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1171373006803 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1171373006804 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1171373006805 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1171373006806 active site 1171373006807 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 1171373006808 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1171373006809 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1171373006810 ring oligomerisation interface [polypeptide binding]; other site 1171373006811 ATP/Mg binding site [chemical binding]; other site 1171373006812 stacking interactions; other site 1171373006813 hinge regions; other site 1171373006814 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1171373006815 oligomerisation interface [polypeptide binding]; other site 1171373006816 mobile loop; other site 1171373006817 roof hairpin; other site 1171373006818 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 1171373006819 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1171373006820 S-adenosylmethionine binding site [chemical binding]; other site 1171373006821 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 1171373006822 putative active site [active] 1171373006823 nucleotide binding site [chemical binding]; other site 1171373006824 nudix motif; other site 1171373006825 putative metal binding site [ion binding]; other site 1171373006826 Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361 1171373006827 putative ligand binding pocket/active site [active] 1171373006828 putative metal binding site [ion binding]; other site 1171373006829 AMMECR1; Region: AMMECR1; pfam01871 1171373006830 AmmeMemoRadiSam system protein A; Region: AmmeMemoSam_A; TIGR04335 1171373006831 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 1171373006832 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1171373006833 FeS/SAM binding site; other site 1171373006834 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 1171373006835 trimer interface [polypeptide binding]; other site 1171373006836 active site 1171373006837 UGMP family protein; Validated; Region: PRK09604 1171373006838 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1171373006839 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1171373006840 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1171373006841 Coenzyme A binding pocket [chemical binding]; other site 1171373006842 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1171373006843 Glycoprotease family; Region: Peptidase_M22; pfam00814 1171373006844 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1171373006845 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1171373006846 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1171373006847 ATP binding site [chemical binding]; other site 1171373006848 Mg++ binding site [ion binding]; other site 1171373006849 motif III; other site 1171373006850 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1171373006851 nucleotide binding region [chemical binding]; other site 1171373006852 ATP-binding site [chemical binding]; other site 1171373006853 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1171373006854 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1171373006855 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 1171373006856 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1171373006857 putative substrate binding site [chemical binding]; other site 1171373006858 putative ATP binding site [chemical binding]; other site 1171373006859 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1171373006860 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1171373006861 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1171373006862 glutaminase active site [active] 1171373006863 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1171373006864 dimer interface [polypeptide binding]; other site 1171373006865 active site 1171373006866 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1171373006867 dimer interface [polypeptide binding]; other site 1171373006868 active site 1171373006869 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1171373006870 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1171373006871 S-adenosylmethionine binding site [chemical binding]; other site 1171373006872 pantothenate kinase; Provisional; Region: PRK05439 1171373006873 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1171373006874 ATP-binding site [chemical binding]; other site 1171373006875 CoA-binding site [chemical binding]; other site 1171373006876 Mg2+-binding site [ion binding]; other site 1171373006877 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 1171373006878 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1171373006879 active site 1171373006880 substrate binding site [chemical binding]; other site 1171373006881 metal binding site [ion binding]; metal-binding site 1171373006882 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1171373006883 short chain dehydrogenase; Provisional; Region: PRK07041 1171373006884 NAD(P) binding site [chemical binding]; other site 1171373006885 active site 1171373006886 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 1171373006887 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1171373006888 23S rRNA interface [nucleotide binding]; other site 1171373006889 L3 interface [polypeptide binding]; other site 1171373006890 hypothetical protein; Provisional; Region: PRK11770 1171373006891 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1171373006892 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1171373006893 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1171373006894 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1171373006895 putative substrate translocation pore; other site 1171373006896 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 1171373006897 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1171373006898 MarR family; Region: MarR; pfam01047 1171373006899 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1171373006900 S-adenosylmethionine binding site [chemical binding]; other site 1171373006901 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1171373006902 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1171373006903 dimerization interface 3.5A [polypeptide binding]; other site 1171373006904 active site 1171373006905 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1171373006906 S-adenosylmethionine binding site [chemical binding]; other site 1171373006907 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1171373006908 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1171373006909 Walker A/P-loop; other site 1171373006910 ATP binding site [chemical binding]; other site 1171373006911 Q-loop/lid; other site 1171373006912 ABC transporter signature motif; other site 1171373006913 Walker B; other site 1171373006914 D-loop; other site 1171373006915 H-loop/switch region; other site 1171373006916 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1171373006917 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1171373006918 Walker A/P-loop; other site 1171373006919 ATP binding site [chemical binding]; other site 1171373006920 Q-loop/lid; other site 1171373006921 ABC transporter signature motif; other site 1171373006922 Walker B; other site 1171373006923 D-loop; other site 1171373006924 H-loop/switch region; other site 1171373006925 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1171373006926 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1171373006927 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1171373006928 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1171373006929 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1171373006930 catalytic triad [active] 1171373006931 N-acetyltransferase; Region: Acetyltransf_2; cl00949 1171373006932 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1171373006933 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1171373006934 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1171373006935 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1171373006936 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1171373006937 alphaNTD homodimer interface [polypeptide binding]; other site 1171373006938 alphaNTD - beta interaction site [polypeptide binding]; other site 1171373006939 alphaNTD - beta' interaction site [polypeptide binding]; other site 1171373006940 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1171373006941 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1171373006942 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1171373006943 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1171373006944 RNA binding surface [nucleotide binding]; other site 1171373006945 30S ribosomal protein S11; Validated; Region: PRK05309 1171373006946 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 1171373006947 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1171373006948 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 1171373006949 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1171373006950 rRNA binding site [nucleotide binding]; other site 1171373006951 predicted 30S ribosome binding site; other site 1171373006952 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1171373006953 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1171373006954 putative active site [active] 1171373006955 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1171373006956 active site 1171373006957 adenylate kinase; Reviewed; Region: adk; PRK00279 1171373006958 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1171373006959 AMP-binding site [chemical binding]; other site 1171373006960 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1171373006961 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1171373006962 SecY translocase; Region: SecY; pfam00344 1171373006963 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1171373006964 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 1171373006965 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 1171373006966 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1171373006967 Walker A/P-loop; other site 1171373006968 ATP binding site [chemical binding]; other site 1171373006969 Q-loop/lid; other site 1171373006970 ABC transporter signature motif; other site 1171373006971 Walker B; other site 1171373006972 D-loop; other site 1171373006973 H-loop/switch region; other site 1171373006974 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1171373006975 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1171373006976 Walker A/P-loop; other site 1171373006977 ATP binding site [chemical binding]; other site 1171373006978 Q-loop/lid; other site 1171373006979 ABC transporter signature motif; other site 1171373006980 Walker B; other site 1171373006981 D-loop; other site 1171373006982 H-loop/switch region; other site 1171373006983 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1171373006984 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 1171373006985 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1171373006986 dimer interface [polypeptide binding]; other site 1171373006987 conserved gate region; other site 1171373006988 putative PBP binding loops; other site 1171373006989 ABC-ATPase subunit interface; other site 1171373006990 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1171373006991 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1171373006992 dimer interface [polypeptide binding]; other site 1171373006993 conserved gate region; other site 1171373006994 putative PBP binding loops; other site 1171373006995 ABC-ATPase subunit interface; other site 1171373006996 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1171373006997 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1171373006998 23S rRNA binding site [nucleotide binding]; other site 1171373006999 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1171373007000 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1171373007001 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1171373007002 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1171373007003 5S rRNA interface [nucleotide binding]; other site 1171373007004 L27 interface [polypeptide binding]; other site 1171373007005 23S rRNA interface [nucleotide binding]; other site 1171373007006 L5 interface [polypeptide binding]; other site 1171373007007 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1171373007008 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1171373007009 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1171373007010 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1171373007011 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 1171373007012 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1171373007013 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1171373007014 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1171373007015 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1171373007016 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1171373007017 RNA binding site [nucleotide binding]; other site 1171373007018 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1171373007019 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1171373007020 Walker A/P-loop; other site 1171373007021 ATP binding site [chemical binding]; other site 1171373007022 Q-loop/lid; other site 1171373007023 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1171373007024 ABC transporter signature motif; other site 1171373007025 Walker B; other site 1171373007026 D-loop; other site 1171373007027 H-loop/switch region; other site 1171373007028 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1171373007029 AAA domain; Region: AAA_21; pfam13304 1171373007030 Walker A/P-loop; other site 1171373007031 ATP binding site [chemical binding]; other site 1171373007032 Q-loop/lid; other site 1171373007033 ABC transporter signature motif; other site 1171373007034 Walker B; other site 1171373007035 D-loop; other site 1171373007036 H-loop/switch region; other site 1171373007037 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1171373007038 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1171373007039 dimer interface [polypeptide binding]; other site 1171373007040 conserved gate region; other site 1171373007041 putative PBP binding loops; other site 1171373007042 ABC-ATPase subunit interface; other site 1171373007043 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1171373007044 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1171373007045 dimer interface [polypeptide binding]; other site 1171373007046 conserved gate region; other site 1171373007047 putative PBP binding loops; other site 1171373007048 ABC-ATPase subunit interface; other site 1171373007049 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1171373007050 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1171373007051 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1171373007052 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1171373007053 DNA binding site [nucleotide binding] 1171373007054 domain linker motif; other site 1171373007055 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1171373007056 dimerization interface [polypeptide binding]; other site 1171373007057 ligand binding site [chemical binding]; other site 1171373007058 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1171373007059 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1171373007060 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1171373007061 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1171373007062 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1171373007063 23S rRNA interface [nucleotide binding]; other site 1171373007064 putative translocon interaction site; other site 1171373007065 signal recognition particle (SRP54) interaction site; other site 1171373007066 L23 interface [polypeptide binding]; other site 1171373007067 trigger factor interaction site; other site 1171373007068 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1171373007069 23S rRNA interface [nucleotide binding]; other site 1171373007070 5S rRNA interface [nucleotide binding]; other site 1171373007071 putative antibiotic binding site [chemical binding]; other site 1171373007072 L25 interface [polypeptide binding]; other site 1171373007073 L27 interface [polypeptide binding]; other site 1171373007074 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1171373007075 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1171373007076 G-X-X-G motif; other site 1171373007077 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1171373007078 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1171373007079 putative translocon binding site; other site 1171373007080 protein-rRNA interface [nucleotide binding]; other site 1171373007081 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1171373007082 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1171373007083 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1171373007084 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1171373007085 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1171373007086 50S ribosomal protein L4; Provisional; Region: rplD; PRK14547 1171373007087 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1171373007088 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1171373007089 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1171373007090 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1171373007091 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1171373007092 active site 1171373007093 KMSKS motif; other site 1171373007094 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 1171373007095 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1171373007096 active site 1171373007097 HIGH motif; other site 1171373007098 nucleotide binding site [chemical binding]; other site 1171373007099 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1171373007100 active site 1171373007101 KMSKS motif; other site 1171373007102 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 1171373007103 Protein of unknown function (DUF664); Region: DUF664; pfam04978 1171373007104 DinB superfamily; Region: DinB_2; pfam12867 1171373007105 Predicted membrane protein [Function unknown]; Region: COG4425 1171373007106 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 1171373007107 elongation factor Tu; Reviewed; Region: PRK00049 1171373007108 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1171373007109 G1 box; other site 1171373007110 GEF interaction site [polypeptide binding]; other site 1171373007111 GTP/Mg2+ binding site [chemical binding]; other site 1171373007112 Switch I region; other site 1171373007113 G2 box; other site 1171373007114 G3 box; other site 1171373007115 Switch II region; other site 1171373007116 G4 box; other site 1171373007117 G5 box; other site 1171373007118 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1171373007119 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1171373007120 Antibiotic Binding Site [chemical binding]; other site 1171373007121 elongation factor G; Reviewed; Region: PRK00007 1171373007122 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1171373007123 G1 box; other site 1171373007124 putative GEF interaction site [polypeptide binding]; other site 1171373007125 GTP/Mg2+ binding site [chemical binding]; other site 1171373007126 Switch I region; other site 1171373007127 G2 box; other site 1171373007128 G3 box; other site 1171373007129 Switch II region; other site 1171373007130 G4 box; other site 1171373007131 G5 box; other site 1171373007132 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1171373007133 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1171373007134 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1171373007135 30S ribosomal protein S7; Validated; Region: PRK05302 1171373007136 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1171373007137 S17 interaction site [polypeptide binding]; other site 1171373007138 S8 interaction site; other site 1171373007139 16S rRNA interaction site [nucleotide binding]; other site 1171373007140 streptomycin interaction site [chemical binding]; other site 1171373007141 23S rRNA interaction site [nucleotide binding]; other site 1171373007142 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1171373007143 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1171373007144 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1171373007145 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1171373007146 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1171373007147 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1171373007148 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1171373007149 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 1171373007150 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1171373007151 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 1171373007152 G-loop; other site 1171373007153 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1171373007154 DNA binding site [nucleotide binding] 1171373007155 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1171373007156 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1171373007157 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1171373007158 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1171373007159 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1171373007160 RPB1 interaction site [polypeptide binding]; other site 1171373007161 RPB10 interaction site [polypeptide binding]; other site 1171373007162 RPB11 interaction site [polypeptide binding]; other site 1171373007163 RPB3 interaction site [polypeptide binding]; other site 1171373007164 RPB12 interaction site [polypeptide binding]; other site 1171373007165 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1171373007166 core dimer interface [polypeptide binding]; other site 1171373007167 peripheral dimer interface [polypeptide binding]; other site 1171373007168 L10 interface [polypeptide binding]; other site 1171373007169 L11 interface [polypeptide binding]; other site 1171373007170 putative EF-Tu interaction site [polypeptide binding]; other site 1171373007171 putative EF-G interaction site [polypeptide binding]; other site 1171373007172 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1171373007173 23S rRNA interface [nucleotide binding]; other site 1171373007174 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1171373007175 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1171373007176 mRNA/rRNA interface [nucleotide binding]; other site 1171373007177 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1171373007178 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1171373007179 putative thiostrepton binding site; other site 1171373007180 23S rRNA interface [nucleotide binding]; other site 1171373007181 L7/L12 interface [polypeptide binding]; other site 1171373007182 L25 interface [polypeptide binding]; other site 1171373007183 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1171373007184 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1171373007185 putative homodimer interface [polypeptide binding]; other site 1171373007186 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1171373007187 heterodimer interface [polypeptide binding]; other site 1171373007188 homodimer interface [polypeptide binding]; other site 1171373007189 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 1171373007190 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 1171373007191 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1171373007192 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1171373007193 homodimer interface [polypeptide binding]; other site 1171373007194 catalytic residue [active] 1171373007195 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 1171373007196 FAD binding domain; Region: FAD_binding_4; pfam01565 1171373007197 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1171373007198 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1171373007199 active site 2 [active] 1171373007200 active site 1 [active] 1171373007201 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1171373007202 active site 1171373007203 catalytic site [active] 1171373007204 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 1171373007205 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1171373007206 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1171373007207 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 1171373007208 putative active site [active] 1171373007209 putative catalytic site [active] 1171373007210 putative DNA binding site [nucleotide binding]; other site 1171373007211 putative phosphate binding site [ion binding]; other site 1171373007212 metal binding site A [ion binding]; metal-binding site 1171373007213 putative AP binding site [nucleotide binding]; other site 1171373007214 putative metal binding site B [ion binding]; other site 1171373007215 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 1171373007216 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1171373007217 substrate binding site [chemical binding]; other site 1171373007218 oxyanion hole (OAH) forming residues; other site 1171373007219 trimer interface [polypeptide binding]; other site 1171373007220 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 1171373007221 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 1171373007222 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 1171373007223 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329 1171373007224 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194 1171373007225 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 1171373007226 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1171373007227 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1171373007228 dimer interface [polypeptide binding]; other site 1171373007229 PYR/PP interface [polypeptide binding]; other site 1171373007230 TPP binding site [chemical binding]; other site 1171373007231 substrate binding site [chemical binding]; other site 1171373007232 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 1171373007233 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 1171373007234 TPP-binding site [chemical binding]; other site 1171373007235 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 1171373007236 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 1171373007237 active site 1171373007238 Zn binding site [ion binding]; other site 1171373007239 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1171373007240 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1171373007241 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1171373007242 TM-ABC transporter signature motif; other site 1171373007243 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1171373007244 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1171373007245 TM-ABC transporter signature motif; other site 1171373007246 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1171373007247 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1171373007248 Walker A/P-loop; other site 1171373007249 ATP binding site [chemical binding]; other site 1171373007250 Q-loop/lid; other site 1171373007251 ABC transporter signature motif; other site 1171373007252 Walker B; other site 1171373007253 D-loop; other site 1171373007254 H-loop/switch region; other site 1171373007255 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1171373007256 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1171373007257 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1171373007258 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1171373007259 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 1171373007260 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 1171373007261 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 1171373007262 amino acid permease (GABA permease); Region: 2A0304; TIGR00907 1171373007263 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1171373007264 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1171373007265 substrate binding pocket [chemical binding]; other site 1171373007266 chain length determination region; other site 1171373007267 substrate-Mg2+ binding site; other site 1171373007268 catalytic residues [active] 1171373007269 aspartate-rich region 1; other site 1171373007270 active site lid residues [active] 1171373007271 aspartate-rich region 2; other site 1171373007272 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1171373007273 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1171373007274 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1171373007275 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1171373007276 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1171373007277 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1171373007278 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1171373007279 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1171373007280 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 1171373007281 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 1171373007282 NADH dehydrogenase subunit J; Provisional; Region: PRK06439 1171373007283 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 1171373007284 4Fe-4S binding domain; Region: Fer4; pfam00037 1171373007285 4Fe-4S binding domain; Region: Fer4; pfam00037 1171373007286 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1171373007287 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1171373007288 NADH dehydrogenase subunit G; Validated; Region: PRK07860 1171373007289 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1171373007290 catalytic loop [active] 1171373007291 iron binding site [ion binding]; other site 1171373007292 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1171373007293 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1171373007294 molybdopterin cofactor binding site; other site 1171373007295 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 1171373007296 molybdopterin cofactor binding site; other site 1171373007297 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 1171373007298 SLBB domain; Region: SLBB; pfam10531 1171373007299 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 1171373007300 NADH dehydrogenase subunit E; Validated; Region: PRK07539 1171373007301 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1171373007302 putative dimer interface [polypeptide binding]; other site 1171373007303 [2Fe-2S] cluster binding site [ion binding]; other site 1171373007304 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 1171373007305 NADH dehydrogenase subunit D; Validated; Region: PRK06075 1171373007306 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 1171373007307 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 1171373007308 NADH dehydrogenase subunit B; Validated; Region: PRK06411 1171373007309 NADH dehydrogenase subunit A; Validated; Region: PRK07928 1171373007310 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 1171373007311 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1171373007312 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1171373007313 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048 1171373007314 RNAase interaction site [polypeptide binding]; other site 1171373007315 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1171373007316 heme ABC exporter, ATP-binding protein CcmA; Region: ccmA; TIGR01189 1171373007317 Walker A/P-loop; other site 1171373007318 ATP binding site [chemical binding]; other site 1171373007319 Q-loop/lid; other site 1171373007320 ABC transporter signature motif; other site 1171373007321 Walker B; other site 1171373007322 D-loop; other site 1171373007323 H-loop/switch region; other site 1171373007324 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1171373007325 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1171373007326 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1171373007327 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1171373007328 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1171373007329 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1171373007330 Walker A/P-loop; other site 1171373007331 ATP binding site [chemical binding]; other site 1171373007332 Q-loop/lid; other site 1171373007333 ABC transporter signature motif; other site 1171373007334 Walker B; other site 1171373007335 D-loop; other site 1171373007336 H-loop/switch region; other site 1171373007337 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1171373007338 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 1171373007339 UbiA prenyltransferase family; Region: UbiA; pfam01040 1171373007340 H+ Antiporter protein; Region: 2A0121; TIGR00900 1171373007341 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1171373007342 putative substrate translocation pore; other site 1171373007343 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 1171373007344 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 1171373007345 DAK2 domain; Region: Dak2; cl03685 1171373007346 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 1171373007347 Deoxycytidylate deaminase [Nucleotide transport and metabolism]; Region: ComEB; COG2131 1171373007348 active site 1171373007349 Zn binding site [ion binding]; other site 1171373007350 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 1171373007351 active site 1171373007352 Substrate binding site; other site 1171373007353 Mg++ binding site; other site 1171373007354 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1171373007355 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1171373007356 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1171373007357 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1171373007358 active site 1171373007359 nucleophile elbow; other site 1171373007360 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1171373007361 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1171373007362 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1171373007363 active site 1171373007364 motif I; other site 1171373007365 motif II; other site 1171373007366 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1171373007367 motif II; other site 1171373007368 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1171373007369 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1171373007370 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1171373007371 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1171373007372 mevalonate kinase; Region: mevalon_kin; TIGR00549 1171373007373 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1171373007374 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1171373007375 diphosphomevalonate decarboxylase; Region: PLN02407 1171373007376 diphosphomevalonate decarboxylase; Region: mevDPdecarb; TIGR01240 1171373007377 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 1171373007378 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1171373007379 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 1171373007380 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 1171373007381 homotetramer interface [polypeptide binding]; other site 1171373007382 FMN binding site [chemical binding]; other site 1171373007383 homodimer contacts [polypeptide binding]; other site 1171373007384 putative active site [active] 1171373007385 putative substrate binding site [chemical binding]; other site 1171373007386 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1171373007387 MULE transposase domain; Region: MULE; pfam10551 1171373007388 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1171373007389 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1171373007390 active site 1171373007391 Predicted transcriptional regulators [Transcription]; Region: COG1695 1171373007392 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1171373007393 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1171373007394 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1171373007395 NAD(P) binding site [chemical binding]; other site 1171373007396 active site 1171373007397 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1171373007398 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1171373007399 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1171373007400 RibD C-terminal domain; Region: RibD_C; cl17279 1171373007401 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1171373007402 Walker A/P-loop; other site 1171373007403 ATP binding site [chemical binding]; other site 1171373007404 Q-loop/lid; other site 1171373007405 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1171373007406 ABC transporter signature motif; other site 1171373007407 Walker B; other site 1171373007408 D-loop; other site 1171373007409 H-loop/switch region; other site 1171373007410 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1171373007411 Walker A/P-loop; other site 1171373007412 ATP binding site [chemical binding]; other site 1171373007413 Q-loop/lid; other site 1171373007414 ABC transporter signature motif; other site 1171373007415 Walker B; other site 1171373007416 D-loop; other site 1171373007417 H-loop/switch region; other site 1171373007418 Predicted transcriptional regulator [Transcription]; Region: COG2378 1171373007419 HTH domain; Region: HTH_11; pfam08279 1171373007420 WYL domain; Region: WYL; pfam13280 1171373007421 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1171373007422 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1171373007423 substrate binding pocket [chemical binding]; other site 1171373007424 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1171373007425 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1171373007426 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1171373007427 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1171373007428 homodimer interface [polypeptide binding]; other site 1171373007429 active site 1171373007430 TDP-binding site; other site 1171373007431 acceptor substrate-binding pocket; other site 1171373007432 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 1171373007433 H+ Antiporter protein; Region: 2A0121; TIGR00900 1171373007434 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1171373007435 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1171373007436 Condensation domain; Region: Condensation; pfam00668 1171373007437 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 1171373007438 putative hydrophobic ligand binding site [chemical binding]; other site 1171373007439 Domain of unknown function (DU1801); Region: DUF1801; cl17490 1171373007440 Bacterial SH3 domain; Region: SH3_3; pfam08239 1171373007441 Bacterial SH3 domain; Region: SH3_3; pfam08239 1171373007442 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1171373007443 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1171373007444 NAD(P) binding site [chemical binding]; other site 1171373007445 putative active site [active] 1171373007446 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1171373007447 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 1171373007448 ligand binding site [chemical binding]; other site 1171373007449 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1171373007450 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1171373007451 Walker A/P-loop; other site 1171373007452 ATP binding site [chemical binding]; other site 1171373007453 Q-loop/lid; other site 1171373007454 ABC transporter signature motif; other site 1171373007455 Walker B; other site 1171373007456 D-loop; other site 1171373007457 H-loop/switch region; other site 1171373007458 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1171373007459 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1171373007460 Walker A/P-loop; other site 1171373007461 ATP binding site [chemical binding]; other site 1171373007462 Q-loop/lid; other site 1171373007463 ABC transporter signature motif; other site 1171373007464 Walker B; other site 1171373007465 D-loop; other site 1171373007466 H-loop/switch region; other site 1171373007467 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1171373007468 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1171373007469 TM-ABC transporter signature motif; other site 1171373007470 Cna protein B-type domain; Region: Cna_B; pfam05738 1171373007471 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1171373007472 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1171373007473 TM-ABC transporter signature motif; other site 1171373007474 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1171373007475 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1171373007476 dimer interface [polypeptide binding]; other site 1171373007477 conserved gate region; other site 1171373007478 putative PBP binding loops; other site 1171373007479 ABC-ATPase subunit interface; other site 1171373007480 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1171373007481 dimer interface [polypeptide binding]; other site 1171373007482 conserved gate region; other site 1171373007483 putative PBP binding loops; other site 1171373007484 ABC-ATPase subunit interface; other site 1171373007485 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1171373007486 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1171373007487 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1171373007488 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1171373007489 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1171373007490 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1171373007491 dimerization interface [polypeptide binding]; other site 1171373007492 putative ATP binding site [chemical binding]; other site 1171373007493 amidophosphoribosyltransferase; Provisional; Region: PRK07847 1171373007494 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1171373007495 active site 1171373007496 tetramer interface [polypeptide binding]; other site 1171373007497 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1171373007498 active site 1171373007499 hypothetical protein; Provisional; Region: PRK07907 1171373007500 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 1171373007501 active site 1171373007502 metal binding site [ion binding]; metal-binding site 1171373007503 dimer interface [polypeptide binding]; other site 1171373007504 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 1171373007505 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 1171373007506 Binuclear center (active site) [active] 1171373007507 K-pathway; other site 1171373007508 Putative proton exit pathway; other site 1171373007509 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1171373007510 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1171373007511 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1171373007512 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1171373007513 dimerization interface [polypeptide binding]; other site 1171373007514 ATP binding site [chemical binding]; other site 1171373007515 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1171373007516 dimerization interface [polypeptide binding]; other site 1171373007517 ATP binding site [chemical binding]; other site 1171373007518 membrane ATPase/protein kinase; Provisional; Region: PRK09435 1171373007519 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 1171373007520 Walker A; other site 1171373007521 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1171373007522 G4 box; other site 1171373007523 G5 box; other site 1171373007524 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1171373007525 putative substrate translocation pore; other site 1171373007526 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1171373007527 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 1171373007528 active site 1171373007529 homodimer interface [polypeptide binding]; other site 1171373007530 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1171373007531 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 1171373007532 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 1171373007533 Zn binding site [ion binding]; other site 1171373007534 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 1171373007535 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1171373007536 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1171373007537 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1171373007538 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1171373007539 putative active site [active] 1171373007540 catalytic triad [active] 1171373007541 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 1171373007542 ATP binding site [chemical binding]; other site 1171373007543 active site 1171373007544 substrate binding site [chemical binding]; other site 1171373007545 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 1171373007546 peroxiredoxin; Region: AhpC; TIGR03137 1171373007547 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1171373007548 dimer interface [polypeptide binding]; other site 1171373007549 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1171373007550 catalytic triad [active] 1171373007551 peroxidatic and resolving cysteines [active] 1171373007552 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 1171373007553 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1171373007554 catalytic residue [active] 1171373007555 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 1171373007556 catalytic residues [active] 1171373007557 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1171373007558 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1171373007559 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1171373007560 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 1171373007561 dimerization interface [polypeptide binding]; other site 1171373007562 adenylosuccinate lyase; Region: purB; TIGR00928 1171373007563 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 1171373007564 tetramer interface [polypeptide binding]; other site 1171373007565 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1171373007566 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1171373007567 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1171373007568 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1171373007569 Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704 1171373007570 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 1171373007571 putative active site [active] 1171373007572 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1171373007573 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1171373007574 GDP-binding site [chemical binding]; other site 1171373007575 ACT binding site; other site 1171373007576 IMP binding site; other site 1171373007577 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1171373007578 Coenzyme A binding pocket [chemical binding]; other site 1171373007579 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 1171373007580 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 1171373007581 putative homodimer interface [polypeptide binding]; other site 1171373007582 putative homotetramer interface [polypeptide binding]; other site 1171373007583 putative allosteric switch controlling residues; other site 1171373007584 putative metal binding site [ion binding]; other site 1171373007585 putative homodimer-homodimer interface [polypeptide binding]; other site 1171373007586 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 1171373007587 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1171373007588 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1171373007589 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1171373007590 active site residue [active] 1171373007591 Domain of unknown function (DUF4291); Region: DUF4291; pfam14124 1171373007592 PemK-like protein; Region: PemK; pfam02452 1171373007593 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1171373007594 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 1171373007595 G1 box; other site 1171373007596 putative GEF interaction site [polypeptide binding]; other site 1171373007597 GTP/Mg2+ binding site [chemical binding]; other site 1171373007598 Switch I region; other site 1171373007599 G2 box; other site 1171373007600 G3 box; other site 1171373007601 Switch II region; other site 1171373007602 G4 box; other site 1171373007603 G5 box; other site 1171373007604 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1171373007605 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1171373007606 Bacterial SH3 domain; Region: SH3_3; pfam08239 1171373007607 Bacterial SH3 domain; Region: SH3_3; pfam08239 1171373007608 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1171373007609 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1171373007610 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1171373007611 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 1171373007612 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1171373007613 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1171373007614 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 1171373007615 heme-binding site [chemical binding]; other site 1171373007616 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1171373007617 putative active site [active] 1171373007618 dimerization interface [polypeptide binding]; other site 1171373007619 putative tRNAtyr binding site [nucleotide binding]; other site 1171373007620 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 1171373007621 AAA domain; Region: AAA_14; pfam13173 1171373007622 H+ Antiporter protein; Region: 2A0121; TIGR00900 1171373007623 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1171373007624 putative substrate translocation pore; other site 1171373007625 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1171373007626 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1171373007627 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 1171373007628 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1171373007629 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1171373007630 DNA binding site [nucleotide binding] 1171373007631 polyphosphate kinase; Provisional; Region: PRK05443 1171373007632 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1171373007633 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1171373007634 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 1171373007635 putative domain interface [polypeptide binding]; other site 1171373007636 putative active site [active] 1171373007637 catalytic site [active] 1171373007638 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 1171373007639 putative domain interface [polypeptide binding]; other site 1171373007640 putative active site [active] 1171373007641 catalytic site [active] 1171373007642 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1171373007643 active site 1171373007644 Ap6A binding site [chemical binding]; other site 1171373007645 nudix motif; other site 1171373007646 metal binding site [ion binding]; metal-binding site 1171373007647 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1171373007648 catalytic core [active] 1171373007649 PBP superfamily domain; Region: PBP_like_2; cl17296 1171373007650 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 1171373007651 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1171373007652 dimer interface [polypeptide binding]; other site 1171373007653 conserved gate region; other site 1171373007654 putative PBP binding loops; other site 1171373007655 ABC-ATPase subunit interface; other site 1171373007656 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1171373007657 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1171373007658 dimer interface [polypeptide binding]; other site 1171373007659 conserved gate region; other site 1171373007660 putative PBP binding loops; other site 1171373007661 ABC-ATPase subunit interface; other site 1171373007662 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 1171373007663 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1171373007664 Walker A/P-loop; other site 1171373007665 ATP binding site [chemical binding]; other site 1171373007666 Q-loop/lid; other site 1171373007667 ABC transporter signature motif; other site 1171373007668 Walker B; other site 1171373007669 D-loop; other site 1171373007670 H-loop/switch region; other site 1171373007671 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1171373007672 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1171373007673 MULE transposase domain; Region: MULE; pfam10551 1171373007674 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1171373007675 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1171373007676 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1171373007677 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1171373007678 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 1171373007679 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 1171373007680 putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773 1171373007681 putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773 1171373007682 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1171373007683 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1171373007684 ABC-ATPase subunit interface; other site 1171373007685 dimer interface [polypeptide binding]; other site 1171373007686 putative PBP binding regions; other site 1171373007687 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1171373007688 anchored repeat-type ABC transporter, ATP-binding subunit; Region: anch_rpt_ABC; TIGR03771 1171373007689 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 1171373007690 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1171373007691 anchored repeat ABC transporter, substrate-binding protein; Region: anch_rpt_subst; TIGR03772 1171373007692 intersubunit interface [polypeptide binding]; other site 1171373007693 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 1171373007694 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1171373007695 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1171373007696 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1171373007697 siderophore binding site; other site 1171373007698 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1171373007699 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1171373007700 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1171373007701 ABC-ATPase subunit interface; other site 1171373007702 dimer interface [polypeptide binding]; other site 1171373007703 putative PBP binding regions; other site 1171373007704 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1171373007705 ABC-ATPase subunit interface; other site 1171373007706 dimer interface [polypeptide binding]; other site 1171373007707 putative PBP binding regions; other site 1171373007708 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1171373007709 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1171373007710 Walker A/P-loop; other site 1171373007711 ATP binding site [chemical binding]; other site 1171373007712 Q-loop/lid; other site 1171373007713 ABC transporter signature motif; other site 1171373007714 Walker B; other site 1171373007715 D-loop; other site 1171373007716 H-loop/switch region; other site 1171373007717 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1171373007718 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1171373007719 FAD binding pocket [chemical binding]; other site 1171373007720 FAD binding motif [chemical binding]; other site 1171373007721 phosphate binding motif [ion binding]; other site 1171373007722 NAD binding pocket [chemical binding]; other site 1171373007723 mycothione reductase; Reviewed; Region: PRK07846 1171373007724 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1171373007725 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1171373007726 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 1171373007727 threonine dehydratase; Reviewed; Region: PRK09224 1171373007728 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1171373007729 tetramer interface [polypeptide binding]; other site 1171373007730 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1171373007731 catalytic residue [active] 1171373007732 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 1171373007733 putative Ile/Val binding site [chemical binding]; other site 1171373007734 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 1171373007735 putative Ile/Val binding site [chemical binding]; other site 1171373007736 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 1171373007737 MMPL family; Region: MMPL; pfam03176 1171373007738 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 1171373007739 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1171373007740 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1171373007741 classical (c) SDRs; Region: SDR_c; cd05233 1171373007742 NAD(P) binding site [chemical binding]; other site 1171373007743 active site 1171373007744 Sporulation and spore germination; Region: Germane; pfam10646 1171373007745 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 1171373007746 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1171373007747 DNA binding residues [nucleotide binding] 1171373007748 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 1171373007749 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 1171373007750 ResB-like family; Region: ResB; pfam05140 1171373007751 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1171373007752 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1171373007753 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1171373007754 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1171373007755 catalytic residues [active] 1171373007756 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1171373007757 catalytic core [active] 1171373007758 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 1171373007759 homodimer interface [polypeptide binding]; other site 1171373007760 active site 1171373007761 SAM binding site [chemical binding]; other site 1171373007762 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1171373007763 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1171373007764 active site 1171373007765 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 1171373007766 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 1171373007767 CoA binding domain; Region: CoA_binding; pfam02629 1171373007768 Glutaredoxin-like domain (DUF836); Region: DUF836; cl17650 1171373007769 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1171373007770 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1171373007771 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1171373007772 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1171373007773 CAAX protease self-immunity; Region: Abi; pfam02517 1171373007774 Proline dehydrogenase; Region: Pro_dh; cl03282 1171373007775 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1171373007776 AP (apurinic/apyrimidinic) site pocket; other site 1171373007777 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1171373007778 DNA interaction; other site 1171373007779 Metal-binding active site; metal-binding site 1171373007780 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 1171373007781 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1171373007782 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1171373007783 S-adenosylmethionine binding site [chemical binding]; other site 1171373007784 DNA repair protein RadA; Provisional; Region: PRK11823 1171373007785 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1171373007786 Walker A motif; other site 1171373007787 ATP binding site [chemical binding]; other site 1171373007788 Walker B motif; other site 1171373007789 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1171373007790 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 1171373007791 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1171373007792 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 1171373007793 ferrochelatase; Reviewed; Region: hemH; PRK00035 1171373007794 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1171373007795 C-terminal domain interface [polypeptide binding]; other site 1171373007796 active site 1171373007797 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1171373007798 active site 1171373007799 N-terminal domain interface [polypeptide binding]; other site 1171373007800 Chlorite dismutase; Region: Chlor_dismutase; pfam06778 1171373007801 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1171373007802 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 1171373007803 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1171373007804 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1171373007805 substrate binding site [chemical binding]; other site 1171373007806 active site 1171373007807 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1171373007808 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1171373007809 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1171373007810 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 1171373007811 active site 1171373007812 domain interfaces; other site 1171373007813 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1171373007814 active site 1171373007815 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1171373007816 dimer interface [polypeptide binding]; other site 1171373007817 active site 1171373007818 Schiff base residues; other site 1171373007819 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1171373007820 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1171373007821 inhibitor-cofactor binding pocket; inhibition site 1171373007822 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1171373007823 catalytic residue [active] 1171373007824 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 1171373007825 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1171373007826 minor groove reading motif; other site 1171373007827 helix-hairpin-helix signature motif; other site 1171373007828 substrate binding pocket [chemical binding]; other site 1171373007829 active site 1171373007830 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 1171373007831 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1171373007832 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1171373007833 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1171373007834 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1171373007835 Walker A/P-loop; other site 1171373007836 ATP binding site [chemical binding]; other site 1171373007837 Q-loop/lid; other site 1171373007838 ABC transporter signature motif; other site 1171373007839 Walker B; other site 1171373007840 D-loop; other site 1171373007841 H-loop/switch region; other site 1171373007842 TOBE domain; Region: TOBE_2; pfam08402 1171373007843 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1171373007844 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1171373007845 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1171373007846 dimer interface [polypeptide binding]; other site 1171373007847 conserved gate region; other site 1171373007848 putative PBP binding loops; other site 1171373007849 ABC-ATPase subunit interface; other site 1171373007850 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 1171373007851 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1171373007852 hypothetical protein; Provisional; Region: PRK06547 1171373007853 Rhomboid family; Region: Rhomboid; pfam01694 1171373007854 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1171373007855 TIGR01777 family protein; Region: yfcH 1171373007856 NAD(P) binding site [chemical binding]; other site 1171373007857 active site 1171373007858 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1171373007859 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1171373007860 putative substrate translocation pore; other site 1171373007861 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1171373007862 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1171373007863 active site 1171373007864 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1171373007865 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1171373007866 NAD(P) binding site [chemical binding]; other site 1171373007867 active site 1171373007868 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 1171373007869 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 1171373007870 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1171373007871 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1171373007872 Clp protease ATP binding subunit; Region: clpC; CHL00095 1171373007873 Clp amino terminal domain; Region: Clp_N; pfam02861 1171373007874 Clp amino terminal domain; Region: Clp_N; pfam02861 1171373007875 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1171373007876 Walker A motif; other site 1171373007877 ATP binding site [chemical binding]; other site 1171373007878 Walker B motif; other site 1171373007879 arginine finger; other site 1171373007880 UvrB/uvrC motif; Region: UVR; pfam02151 1171373007881 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1171373007882 Walker A motif; other site 1171373007883 ATP binding site [chemical binding]; other site 1171373007884 Walker B motif; other site 1171373007885 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1171373007886 Lsr2; Region: Lsr2; pfam11774 1171373007887 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 1171373007888 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 1171373007889 conjugal transfer pilus assembly protein TraB; Provisional; Region: PRK13729 1171373007890 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 1171373007891 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1171373007892 catalytic center binding site [active] 1171373007893 ATP binding site [chemical binding]; other site 1171373007894 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1171373007895 homooctamer interface [polypeptide binding]; other site 1171373007896 active site 1171373007897 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1171373007898 dihydropteroate synthase; Region: DHPS; TIGR01496 1171373007899 substrate binding pocket [chemical binding]; other site 1171373007900 dimer interface [polypeptide binding]; other site 1171373007901 inhibitor binding site; inhibition site 1171373007902 GTP cyclohydrolase I; Provisional; Region: PLN03044 1171373007903 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1171373007904 homodecamer interface [polypeptide binding]; other site 1171373007905 active site 1171373007906 putative catalytic site residues [active] 1171373007907 zinc binding site [ion binding]; other site 1171373007908 GTP-CH-I/GFRP interaction surface; other site 1171373007909 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1171373007910 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1171373007911 Walker A motif; other site 1171373007912 ATP binding site [chemical binding]; other site 1171373007913 Walker B motif; other site 1171373007914 arginine finger; other site 1171373007915 Peptidase family M41; Region: Peptidase_M41; pfam01434 1171373007916 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1171373007917 active site 1171373007918 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1171373007919 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1171373007920 Ligand Binding Site [chemical binding]; other site 1171373007921 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 1171373007922 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1171373007923 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 1171373007924 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1171373007925 dimer interface [polypeptide binding]; other site 1171373007926 substrate binding site [chemical binding]; other site 1171373007927 metal binding sites [ion binding]; metal-binding site 1171373007928 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1171373007929 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 1171373007930 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1171373007931 catalytic core [active] 1171373007932 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1171373007933 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1171373007934 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1171373007935 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1171373007936 metal ion-dependent adhesion site (MIDAS); other site 1171373007937 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1171373007938 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 1171373007939 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1171373007940 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1171373007941 putative DNA binding site [nucleotide binding]; other site 1171373007942 AsnC family; Region: AsnC_trans_reg; pfam01037 1171373007943 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 1171373007944 dimer interface [polypeptide binding]; other site 1171373007945 catalytic triad [active] 1171373007946 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1171373007947 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1171373007948 Walker A/P-loop; other site 1171373007949 ATP binding site [chemical binding]; other site 1171373007950 Q-loop/lid; other site 1171373007951 ABC transporter signature motif; other site 1171373007952 Walker B; other site 1171373007953 D-loop; other site 1171373007954 H-loop/switch region; other site 1171373007955 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1171373007956 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1171373007957 Walker A/P-loop; other site 1171373007958 ATP binding site [chemical binding]; other site 1171373007959 Q-loop/lid; other site 1171373007960 ABC transporter signature motif; other site 1171373007961 Walker B; other site 1171373007962 D-loop; other site 1171373007963 H-loop/switch region; other site 1171373007964 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1171373007965 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 1171373007966 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1171373007967 dimer interface [polypeptide binding]; other site 1171373007968 conserved gate region; other site 1171373007969 putative PBP binding loops; other site 1171373007970 ABC-ATPase subunit interface; other site 1171373007971 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1171373007972 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1171373007973 dimer interface [polypeptide binding]; other site 1171373007974 conserved gate region; other site 1171373007975 putative PBP binding loops; other site 1171373007976 ABC-ATPase subunit interface; other site 1171373007977 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1171373007978 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1171373007979 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1171373007980 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1171373007981 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1171373007982 catalytic residue [active] 1171373007983 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 1171373007984 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 1171373007985 active site 1171373007986 dimer interface [polypeptide binding]; other site 1171373007987 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1171373007988 catalytic triad [active] 1171373007989 Beta-lactamase; Region: Beta-lactamase; pfam00144 1171373007990 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1171373007991 Predicted flavoprotein [General function prediction only]; Region: COG0431 1171373007992 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1171373007993 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1171373007994 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 1171373007995 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 1171373007996 CGNR zinc finger; Region: zf-CGNR; pfam11706 1171373007997 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 1171373007998 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1171373007999 TAP-like protein; Region: Abhydrolase_4; pfam08386 1171373008000 PSP1 C-terminal conserved region; Region: PSP1; cl00770 1171373008001 DoxX; Region: DoxX; pfam07681 1171373008002 DNA polymerase III subunit delta'; Validated; Region: PRK07940 1171373008003 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1171373008004 thymidylate kinase; Validated; Region: tmk; PRK00698 1171373008005 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1171373008006 TMP-binding site; other site 1171373008007 ATP-binding site [chemical binding]; other site 1171373008008 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1171373008009 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1171373008010 active site 1171373008011 interdomain interaction site; other site 1171373008012 putative metal-binding site [ion binding]; other site 1171373008013 nucleotide binding site [chemical binding]; other site 1171373008014 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 1171373008015 domain I; other site 1171373008016 phosphate binding site [ion binding]; other site 1171373008017 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1171373008018 domain II; other site 1171373008019 domain III; other site 1171373008020 nucleotide binding site [chemical binding]; other site 1171373008021 DNA binding groove [nucleotide binding] 1171373008022 catalytic site [active] 1171373008023 domain IV; other site 1171373008024 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1171373008025 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1171373008026 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 1171373008027 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 1171373008028 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1171373008029 S-adenosylmethionine binding site [chemical binding]; other site 1171373008030 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 1171373008031 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1171373008032 ATP binding site [chemical binding]; other site 1171373008033 putative Mg++ binding site [ion binding]; other site 1171373008034 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1171373008035 nucleotide binding region [chemical binding]; other site 1171373008036 ATP-binding site [chemical binding]; other site 1171373008037 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1171373008038 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1171373008039 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 1171373008040 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 1171373008041 Abi-like protein; Region: Abi_2; cl01988 1171373008042 Predicted ATPase [General function prediction only]; Region: COG4637 1171373008043 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1171373008044 Walker A/P-loop; other site 1171373008045 ATP binding site [chemical binding]; other site 1171373008046 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1171373008047 Q-loop/lid; other site 1171373008048 ABC transporter signature motif; other site 1171373008049 Walker B; other site 1171373008050 D-loop; other site 1171373008051 H-loop/switch region; other site 1171373008052 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 1171373008053 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1171373008054 homodimer interface [polypeptide binding]; other site 1171373008055 substrate-cofactor binding pocket; other site 1171373008056 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1171373008057 catalytic residue [active] 1171373008058 helicase/secretion neighborhood ATPase; Region: heli_sec_ATPase; TIGR03819 1171373008059 Type II/IV secretion system protein; Region: T2SE; pfam00437 1171373008060 Walker A motif; other site 1171373008061 ATP binding site [chemical binding]; other site 1171373008062 Walker B motif; other site 1171373008063 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 1171373008064 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1171373008065 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 1171373008066 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1171373008067 putative active site [active] 1171373008068 putative CoA binding site [chemical binding]; other site 1171373008069 nudix motif; other site 1171373008070 metal binding site [ion binding]; metal-binding site 1171373008071 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1171373008072 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1171373008073 catalytic residues [active] 1171373008074 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1171373008075 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1171373008076 minor groove reading motif; other site 1171373008077 helix-hairpin-helix signature motif; other site 1171373008078 substrate binding pocket [chemical binding]; other site 1171373008079 active site 1171373008080 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1171373008081 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1171373008082 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1171373008083 ligand binding site [chemical binding]; other site 1171373008084 flexible hinge region; other site 1171373008085 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1171373008086 putative switch regulator; other site 1171373008087 non-specific DNA interactions [nucleotide binding]; other site 1171373008088 DNA binding site [nucleotide binding] 1171373008089 sequence specific DNA binding site [nucleotide binding]; other site 1171373008090 putative cAMP binding site [chemical binding]; other site 1171373008091 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 1171373008092 homotrimer interaction site [polypeptide binding]; other site 1171373008093 putative active site [active] 1171373008094 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 1171373008095 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1171373008096 Transglycosylase; Region: Transgly; pfam00912 1171373008097 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1171373008098 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1171373008099 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1171373008100 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1171373008101 putative active site [active] 1171373008102 putative metal binding site [ion binding]; other site 1171373008103 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1171373008104 Uncharacterized conserved protein (DUF2305); Region: DUF2305; pfam10230 1171373008105 nucleophilic elbow; other site 1171373008106 catalytic triad; other site 1171373008107 S-methylmethionine transporter; Provisional; Region: PRK11387 1171373008108 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 1171373008109 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 1171373008110 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1171373008111 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1171373008112 putative Zn2+ binding site [ion binding]; other site 1171373008113 putative DNA binding site [nucleotide binding]; other site 1171373008114 Tubby C 2; Region: Tub_2; cl02043 1171373008115 Scramblase; Region: Scramblase; pfam03803 1171373008116 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1171373008117 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1171373008118 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1171373008119 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1171373008120 conserved gate region; other site 1171373008121 putative PBP binding loops; other site 1171373008122 ABC-ATPase subunit interface; other site 1171373008123 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1171373008124 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1171373008125 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1171373008126 dimer interface [polypeptide binding]; other site 1171373008127 conserved gate region; other site 1171373008128 putative PBP binding loops; other site 1171373008129 ABC-ATPase subunit interface; other site 1171373008130 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1171373008131 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1171373008132 Walker A/P-loop; other site 1171373008133 ATP binding site [chemical binding]; other site 1171373008134 Q-loop/lid; other site 1171373008135 ABC transporter signature motif; other site 1171373008136 Walker B; other site 1171373008137 D-loop; other site 1171373008138 H-loop/switch region; other site 1171373008139 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1171373008140 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1171373008141 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1171373008142 Walker A/P-loop; other site 1171373008143 ATP binding site [chemical binding]; other site 1171373008144 Q-loop/lid; other site 1171373008145 ABC transporter signature motif; other site 1171373008146 Walker B; other site 1171373008147 D-loop; other site 1171373008148 H-loop/switch region; other site 1171373008149 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1171373008150 Uncharacterized protein conserved in bacteria (DUF2330); Region: DUF2330; cl01827 1171373008151 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 1171373008152 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1171373008153 active site 1171373008154 hypothetical protein; Validated; Region: PRK02101 1171373008155 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1171373008156 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1171373008157 Carbohydrate kinase and ribulose-phosphate 3-epimerase fusion proteins-like; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CarbK-RPE_like; cd07783 1171373008158 Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069 1171373008159 N- and C-terminal domain interface [polypeptide binding]; other site 1171373008160 active site 1171373008161 MgATP binding site [chemical binding]; other site 1171373008162 catalytic site [active] 1171373008163 metal binding site [ion binding]; metal-binding site 1171373008164 putative carbohydrate binding site [chemical binding]; other site 1171373008165 putative homodimer interface [polypeptide binding]; other site 1171373008166 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 1171373008167 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1171373008168 active site 1171373008169 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1171373008170 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1171373008171 ATP binding site [chemical binding]; other site 1171373008172 putative Mg++ binding site [ion binding]; other site 1171373008173 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1171373008174 nucleotide binding region [chemical binding]; other site 1171373008175 ATP-binding site [chemical binding]; other site 1171373008176 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1171373008177 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 1171373008178 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1171373008179 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1171373008180 DNA binding residues [nucleotide binding] 1171373008181 Nuclease-related domain; Region: NERD; pfam08378 1171373008182 Family description; Region: UvrD_C_2; pfam13538 1171373008183 NAD-dependent deacetylase; Provisional; Region: PRK00481 1171373008184 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 1171373008185 NAD+ binding site [chemical binding]; other site 1171373008186 substrate binding site [chemical binding]; other site 1171373008187 Zn binding site [ion binding]; other site 1171373008188 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 1171373008189 active site 1171373008190 catalytic site [active] 1171373008191 substrate binding site [chemical binding]; other site 1171373008192 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1171373008193 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 1171373008194 HD domain; Region: HD_4; pfam13328 1171373008195 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1171373008196 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 1171373008197 Thioredoxin; Region: Thioredoxin_4; cl17273 1171373008198 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1171373008199 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1171373008200 DNA binding residues [nucleotide binding] 1171373008201 dimerization interface [polypeptide binding]; other site 1171373008202 hydroperoxidase II; Provisional; Region: katE; PRK11249 1171373008203 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 1171373008204 heme binding pocket [chemical binding]; other site 1171373008205 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 1171373008206 domain interactions; other site 1171373008207 Cation efflux family; Region: Cation_efflux; pfam01545 1171373008208 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1171373008209 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1171373008210 substrate binding pocket [chemical binding]; other site 1171373008211 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 1171373008212 nucleotide binding site [chemical binding]; other site 1171373008213 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1171373008214 ent-kaurene oxidase; Region: PLN02655 1171373008215 oxidoreductase; Provisional; Region: PRK06128 1171373008216 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1171373008217 NAD binding site [chemical binding]; other site 1171373008218 metal binding site [ion binding]; metal-binding site 1171373008219 active site 1171373008220 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1171373008221 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1171373008222 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1171373008223 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1171373008224 dimerization interface [polypeptide binding]; other site 1171373008225 DPS ferroxidase diiron center [ion binding]; other site 1171373008226 ion pore; other site 1171373008227 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1171373008228 classical (c) SDRs; Region: SDR_c; cd05233 1171373008229 NAD(P) binding site [chemical binding]; other site 1171373008230 active site 1171373008231 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1171373008232 DDE superfamily endonuclease; Region: DDE_4; pfam13359 1171373008233 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1171373008234 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 1171373008235 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 1171373008236 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 1171373008237 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 1171373008238 heme binding site [chemical binding]; other site 1171373008239 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 1171373008240 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1171373008241 metal binding site 2 [ion binding]; metal-binding site 1171373008242 putative DNA binding helix; other site 1171373008243 metal binding site 1 [ion binding]; metal-binding site 1171373008244 dimer interface [polypeptide binding]; other site 1171373008245 structural Zn2+ binding site [ion binding]; other site 1171373008246 cation transport regulator; Reviewed; Region: chaB; PRK09582 1171373008247 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1171373008248 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1171373008249 active site 1171373008250 catalytic tetrad [active] 1171373008251 cyanate transporter; Region: CynX; TIGR00896 1171373008252 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1171373008253 putative substrate translocation pore; other site 1171373008254 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 1171373008255 K+ potassium transporter; Region: K_trans; pfam02705 1171373008256 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 1171373008257 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1171373008258 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1171373008259 Ligand Binding Site [chemical binding]; other site 1171373008260 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1171373008261 ATP binding site [chemical binding]; other site 1171373008262 G-X-G motif; other site 1171373008263 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1171373008264 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1171373008265 active site 1171373008266 phosphorylation site [posttranslational modification] 1171373008267 intermolecular recognition site; other site 1171373008268 dimerization interface [polypeptide binding]; other site 1171373008269 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1171373008270 DNA binding site [nucleotide binding] 1171373008271 helicase Cas3; Provisional; Region: PRK09694 1171373008272 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 1171373008273 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1171373008274 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09729 1171373008275 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cl09608 1171373008276 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 1171373008277 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09756 1171373008278 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 1171373008279 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 1171373008280 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09755 1171373008281 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1171373008282 MULE transposase domain; Region: MULE; pfam10551 1171373008283 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 1171373008284 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1171373008285 DDE superfamily endonuclease; Region: DDE_4; pfam13359 1171373008286 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 1171373008287 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1171373008288 metabolite-proton symporter; Region: 2A0106; TIGR00883 1171373008289 putative substrate translocation pore; other site 1171373008290 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 1171373008291 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1171373008292 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1171373008293 Bacterial transcriptional regulator; Region: IclR; pfam01614 1171373008294 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1171373008295 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1171373008296 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1171373008297 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1171373008298 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1171373008299 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1171373008300 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1171373008301 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1171373008302 dimer interface [polypeptide binding]; other site 1171373008303 phosphorylation site [posttranslational modification] 1171373008304 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1171373008305 ATP binding site [chemical binding]; other site 1171373008306 Mg2+ binding site [ion binding]; other site 1171373008307 G-X-G motif; other site 1171373008308 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1171373008309 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1171373008310 active site 1171373008311 phosphorylation site [posttranslational modification] 1171373008312 intermolecular recognition site; other site 1171373008313 dimerization interface [polypeptide binding]; other site 1171373008314 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1171373008315 DNA binding site [nucleotide binding] 1171373008316 Bacitracin resistance protein BacA; Region: BacA; pfam02673 1171373008317 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1171373008318 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1171373008319 active site 1171373008320 Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424 1171373008321 transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481 1171373008322 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1171373008323 DNA-binding site [nucleotide binding]; DNA binding site 1171373008324 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1171373008325 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1171373008326 homodimer interface [polypeptide binding]; other site 1171373008327 catalytic residue [active] 1171373008328 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1171373008329 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1171373008330 NAD(P) binding site [chemical binding]; other site 1171373008331 active site 1171373008332 hypothetical protein; Provisional; Region: PRK06062 1171373008333 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1171373008334 inhibitor-cofactor binding pocket; inhibition site 1171373008335 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1171373008336 catalytic residue [active] 1171373008337 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1171373008338 MULE transposase domain; Region: MULE; pfam10551 1171373008339 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1171373008340 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1171373008341 NAD(P) binding site [chemical binding]; other site 1171373008342 active site 1171373008343 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 1171373008344 putative active site [active] 1171373008345 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1171373008346 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1171373008347 substrate binding site [chemical binding]; other site 1171373008348 dimer interface [polypeptide binding]; other site 1171373008349 ATP binding site [chemical binding]; other site 1171373008350 Protein of unknown function (DUF2961); Region: DUF2961; pfam11175 1171373008351 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1171373008352 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1171373008353 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1171373008354 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1171373008355 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1171373008356 putative PBP binding loops; other site 1171373008357 ABC-ATPase subunit interface; other site 1171373008358 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1171373008359 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1171373008360 dimer interface [polypeptide binding]; other site 1171373008361 conserved gate region; other site 1171373008362 putative PBP binding loops; other site 1171373008363 ABC-ATPase subunit interface; other site 1171373008364 beta-Glucocerebrosidase 2 N terminal; Region: GBA2_N; pfam12215 1171373008365 Protein of unknown function, DUF608; Region: DUF608; pfam04685 1171373008366 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1171373008367 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1171373008368 DNA binding site [nucleotide binding] 1171373008369 domain linker motif; other site 1171373008370 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1171373008371 ligand binding site [chemical binding]; other site 1171373008372 dimerization interface [polypeptide binding]; other site 1171373008373 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1171373008374 Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069 1171373008375 nucleotide binding site [chemical binding]; other site 1171373008376 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1171373008377 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 1171373008378 putative NAD(P) binding site [chemical binding]; other site 1171373008379 catalytic Zn binding site [ion binding]; other site 1171373008380 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1171373008381 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1171373008382 DNA binding residues [nucleotide binding] 1171373008383 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1171373008384 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1171373008385 intersubunit interface [polypeptide binding]; other site 1171373008386 active site 1171373008387 catalytic residue [active] 1171373008388 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1171373008389 L-iditol 2-dehydrogenase; Region: iditol_2_DH_like; cd08235 1171373008390 putative NAD(P) binding site [chemical binding]; other site 1171373008391 catalytic Zn binding site [ion binding]; other site 1171373008392 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 1171373008393 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1171373008394 active site 1171373008395 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1171373008396 catalytic triad [active] 1171373008397 dimer interface [polypeptide binding]; other site 1171373008398 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1171373008399 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1171373008400 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1171373008401 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1171373008402 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1171373008403 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1171373008404 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1171373008405 LGFP repeat; Region: LGFP; pfam08310 1171373008406 LGFP repeat; Region: LGFP; pfam08310 1171373008407 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 1171373008408 Bacterial SH3 domain; Region: SH3_3; cl17532 1171373008409 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 1171373008410 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1171373008411 AzlC protein; Region: AzlC; pfam03591 1171373008412 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 1171373008413 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1171373008414 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1171373008415 putative active site [active] 1171373008416 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1171373008417 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1171373008418 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1171373008419 homodimer interface [polypeptide binding]; other site 1171373008420 catalytic residue [active] 1171373008421 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 1171373008422 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 1171373008423 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1171373008424 potassium/proton antiporter; Reviewed; Region: PRK05326 1171373008425 TrkA-C domain; Region: TrkA_C; pfam02080 1171373008426 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1171373008427 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1171373008428 Walker A/P-loop; other site 1171373008429 ATP binding site [chemical binding]; other site 1171373008430 Q-loop/lid; other site 1171373008431 ABC transporter signature motif; other site 1171373008432 Walker B; other site 1171373008433 D-loop; other site 1171373008434 H-loop/switch region; other site 1171373008435 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1171373008436 dimer interface [polypeptide binding]; other site 1171373008437 conserved gate region; other site 1171373008438 ABC-ATPase subunit interface; other site 1171373008439 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 1171373008440 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1171373008441 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1171373008442 Beta-lactamase; Region: Beta-lactamase; pfam00144 1171373008443 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1171373008444 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1171373008445 active site 1171373008446 aromatic amino acid exporter; Provisional; Region: PRK11689 1171373008447 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 1171373008448 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1171373008449 putative NAD(P) binding site [chemical binding]; other site 1171373008450 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1171373008451 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1171373008452 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1171373008453 nucleoside/Zn binding site; other site 1171373008454 dimer interface [polypeptide binding]; other site 1171373008455 catalytic motif [active] 1171373008456 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 1171373008457 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1171373008458 active site 1171373008459 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1171373008460 active site 2 [active] 1171373008461 active site 1 [active] 1171373008462 PA2301 is an uncharacterized Pseudomonas aeruginosa protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's...; Region: PA2301; cd04939 1171373008463 putative deacylase active site [active] 1171373008464 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1171373008465 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1171373008466 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1171373008467 1,4-alpha-glucan branching enzyme [Carbohydrate transport and metabolism]; Region: GlgB; COG0296 1171373008468 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 1171373008469 catalytic site [active] 1171373008470 active site 1171373008471 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1171373008472 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1171373008473 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1171373008474 NAD(P) binding site [chemical binding]; other site 1171373008475 substrate binding site [chemical binding]; other site 1171373008476 dimer interface [polypeptide binding]; other site 1171373008477 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1171373008478 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1171373008479 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 1171373008480 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 1171373008481 active site 1171373008482 catalytic site [active] 1171373008483 metal binding site [ion binding]; metal-binding site 1171373008484 dimer interface [polypeptide binding]; other site 1171373008485 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1171373008486 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1171373008487 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1171373008488 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1171373008489 DNA binding site [nucleotide binding] 1171373008490 domain linker motif; other site 1171373008491 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 1171373008492 ligand binding site [chemical binding]; other site 1171373008493 dimerization interface (open form) [polypeptide binding]; other site 1171373008494 dimerization interface (closed form) [polypeptide binding]; other site 1171373008495 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 1171373008496 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1171373008497 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1171373008498 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1171373008499 Na binding site [ion binding]; other site 1171373008500 Integrase core domain; Region: rve; pfam00665 1171373008501 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 1171373008502 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 1171373008503 NAD(P) binding site [chemical binding]; other site 1171373008504 argininosuccinate synthase; Validated; Region: PRK05370 1171373008505 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1171373008506 HTH domain; Region: HTH_11; cl17392 1171373008507 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1171373008508 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1171373008509 active site 1171373008510 motif I; other site 1171373008511 motif II; other site 1171373008512 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1171373008513 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1171373008514 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1171373008515 DNA binding site [nucleotide binding] 1171373008516 domain linker motif; other site 1171373008517 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1171373008518 ligand binding site [chemical binding]; other site 1171373008519 dimerization interface [polypeptide binding]; other site 1171373008520 Integrase core domain; Region: rve; pfam00665 1171373008521 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1171373008522 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1171373008523 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1171373008524 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1171373008525 dimer interface [polypeptide binding]; other site 1171373008526 conserved gate region; other site 1171373008527 putative PBP binding loops; other site 1171373008528 ABC-ATPase subunit interface; other site 1171373008529 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1171373008530 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1171373008531 dimer interface [polypeptide binding]; other site 1171373008532 conserved gate region; other site 1171373008533 putative PBP binding loops; other site 1171373008534 ABC-ATPase subunit interface; other site 1171373008535 Endo-beta-mannanase [Carbohydrate transport and metabolism]; Region: COG3934 1171373008536 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1171373008537 beta-galactosidase; Region: BGL; TIGR03356 1171373008538 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1171373008539 nucleotide binding site/active site [active] 1171373008540 HIT family signature motif; other site 1171373008541 catalytic residue [active] 1171373008542 seryl-tRNA synthetase; Provisional; Region: PRK05431 1171373008543 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1171373008544 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1171373008545 dimer interface [polypeptide binding]; other site 1171373008546 active site 1171373008547 motif 1; other site 1171373008548 motif 2; other site 1171373008549 motif 3; other site 1171373008550 prephenate dehydratase; Provisional; Region: PRK11898 1171373008551 Prephenate dehydratase; Region: PDT; pfam00800 1171373008552 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1171373008553 putative L-Phe binding site [chemical binding]; other site 1171373008554 Leucyl/phenylalanyl-tRNA protein transferase; Region: Leu_Phe_trans; cl17317 1171373008555 EcsC protein family; Region: EcsC; pfam12787 1171373008556 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1171373008557 alanine racemase; Reviewed; Region: alr; PRK00053 1171373008558 active site 1171373008559 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1171373008560 dimer interface [polypeptide binding]; other site 1171373008561 substrate binding site [chemical binding]; other site 1171373008562 catalytic residues [active] 1171373008563 Domain of unknown function (DUF4282); Region: DUF4282; pfam14110 1171373008564 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1171373008565 E3 interaction surface; other site 1171373008566 lipoyl attachment site [posttranslational modification]; other site 1171373008567 e3 binding domain; Region: E3_binding; pfam02817 1171373008568 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 1171373008569 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1171373008570 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1171373008571 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1171373008572 alpha subunit interface [polypeptide binding]; other site 1171373008573 TPP binding site [chemical binding]; other site 1171373008574 heterodimer interface [polypeptide binding]; other site 1171373008575 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1171373008576 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1171373008577 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1171373008578 tetramer interface [polypeptide binding]; other site 1171373008579 TPP-binding site [chemical binding]; other site 1171373008580 heterodimer interface [polypeptide binding]; other site 1171373008581 phosphorylation loop region [posttranslational modification] 1171373008582 Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232 1171373008583 radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053 1171373008584 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1171373008585 FeS/SAM binding site; other site 1171373008586 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1171373008587 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 1171373008588 active site 1171373008589 catalytic site [active] 1171373008590 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 1171373008591 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 1171373008592 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 1171373008593 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 1171373008594 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 1171373008595 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 1171373008596 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1171373008597 metabolite-proton symporter; Region: 2A0106; TIGR00883 1171373008598 putative substrate translocation pore; other site 1171373008599 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 1171373008600 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 1171373008601 metal binding site [ion binding]; metal-binding site 1171373008602 dimer interface [polypeptide binding]; other site 1171373008603 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1171373008604 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1171373008605 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1171373008606 homodimer interface [polypeptide binding]; other site 1171373008607 catalytic residue [active] 1171373008608 ectoine utilization protein EutD; Region: ectoine_eutD; TIGR02993 1171373008609 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1171373008610 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1171373008611 active site 1171373008612 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1171373008613 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1171373008614 DNA-binding site [nucleotide binding]; DNA binding site 1171373008615 FCD domain; Region: FCD; pfam07729 1171373008616 4-aminobutyrate aminotransferase; Provisional; Region: PRK08117 1171373008617 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1171373008618 inhibitor-cofactor binding pocket; inhibition site 1171373008619 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1171373008620 catalytic residue [active] 1171373008621 succinic semialdehyde dehydrogenase; Region: PLN02278 1171373008622 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1171373008623 tetramerization interface [polypeptide binding]; other site 1171373008624 NAD(P) binding site [chemical binding]; other site 1171373008625 catalytic residues [active] 1171373008626 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973 1171373008627 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1171373008628 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1171373008629 S-adenosylmethionine binding site [chemical binding]; other site 1171373008630 Protein of unknown function (DUF3830); Region: DUF3830; pfam12903 1171373008631 putative amidase; Provisional; Region: PRK06169 1171373008632 Amidase; Region: Amidase; pfam01425 1171373008633 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1171373008634 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 1171373008635 NAD binding site [chemical binding]; other site 1171373008636 ligand binding site [chemical binding]; other site 1171373008637 catalytic site [active] 1171373008638 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1171373008639 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1171373008640 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1171373008641 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1171373008642 Walker A/P-loop; other site 1171373008643 ATP binding site [chemical binding]; other site 1171373008644 Q-loop/lid; other site 1171373008645 ABC transporter signature motif; other site 1171373008646 Walker B; other site 1171373008647 D-loop; other site 1171373008648 H-loop/switch region; other site 1171373008649 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1171373008650 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1171373008651 dimer interface [polypeptide binding]; other site 1171373008652 conserved gate region; other site 1171373008653 putative PBP binding loops; other site 1171373008654 ABC-ATPase subunit interface; other site 1171373008655 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1171373008656 dimer interface [polypeptide binding]; other site 1171373008657 conserved gate region; other site 1171373008658 ABC-ATPase subunit interface; other site 1171373008659 ectoine/hydroxyectoine ABC transporter solute-binding protein; Region: ectoine_ehuB; TIGR02995 1171373008660 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1171373008661 substrate binding pocket [chemical binding]; other site 1171373008662 membrane-bound complex binding site; other site 1171373008663 hinge residues; other site 1171373008664 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 1171373008665 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1171373008666 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1171373008667 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1171373008668 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1171373008669 dimerization interface [polypeptide binding]; other site 1171373008670 putative DNA binding site [nucleotide binding]; other site 1171373008671 putative Zn2+ binding site [ion binding]; other site 1171373008672 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_8; cd08901 1171373008673 putative hydrophobic ligand binding site [chemical binding]; other site 1171373008674 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 1171373008675 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1171373008676 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1171373008677 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 1171373008678 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 1171373008679 Mrr N-terminal domain; Region: Mrr_N; pfam14338 1171373008680 Restriction endonuclease; Region: Mrr_cat; pfam04471 1171373008681 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1171373008682 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1171373008683 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1171373008684 active site 1171373008685 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 1171373008686 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1171373008687 FAD binding pocket [chemical binding]; other site 1171373008688 conserved FAD binding motif [chemical binding]; other site 1171373008689 phosphate binding motif [ion binding]; other site 1171373008690 beta-alpha-beta structure motif; other site 1171373008691 NAD binding pocket [chemical binding]; other site 1171373008692 FMN-binding domain; Region: FMN_bind; cl01081 1171373008693 ApbE family; Region: ApbE; pfam02424 1171373008694 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1171373008695 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1171373008696 dimer interface [polypeptide binding]; other site 1171373008697 phosphorylation site [posttranslational modification] 1171373008698 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1171373008699 ATP binding site [chemical binding]; other site 1171373008700 Mg2+ binding site [ion binding]; other site 1171373008701 G-X-G motif; other site 1171373008702 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1171373008703 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1171373008704 active site 1171373008705 phosphorylation site [posttranslational modification] 1171373008706 intermolecular recognition site; other site 1171373008707 dimerization interface [polypeptide binding]; other site 1171373008708 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1171373008709 DNA binding site [nucleotide binding] 1171373008710 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 1171373008711 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 1171373008712 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1171373008713 substrate binding [chemical binding]; other site 1171373008714 active site 1171373008715 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1171373008716 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1171373008717 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 1171373008718 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1171373008719 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1171373008720 uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804 1171373008721 N- and C-terminal domain interface [polypeptide binding]; other site 1171373008722 putative active site [active] 1171373008723 MgATP binding site [chemical binding]; other site 1171373008724 catalytic site [active] 1171373008725 metal binding site [ion binding]; metal-binding site 1171373008726 putative xylulose binding site [chemical binding]; other site 1171373008727 putative homodimer interface [polypeptide binding]; other site 1171373008728 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1171373008729 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 1171373008730 putative N- and C-terminal domain interface [polypeptide binding]; other site 1171373008731 putative active site [active] 1171373008732 MgATP binding site [chemical binding]; other site 1171373008733 catalytic site [active] 1171373008734 metal binding site [ion binding]; metal-binding site 1171373008735 putative xylulose binding site [chemical binding]; other site 1171373008736 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_10; cd12171 1171373008737 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1171373008738 putative ligand binding site [chemical binding]; other site 1171373008739 putative NAD binding site [chemical binding]; other site 1171373008740 catalytic site [active] 1171373008741 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases [Carbohydrate transport and metabolism]; Region: AraD; COG0235 1171373008742 intersubunit interface [polypeptide binding]; other site 1171373008743 active site 1171373008744 Zn2+ binding site [ion binding]; other site 1171373008745 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1171373008746 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1171373008747 active site 1171373008748 catalytic tetrad [active] 1171373008749 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 1171373008750 Class I aldolases; Region: Aldolase_Class_I; cl17187 1171373008751 catalytic residue [active] 1171373008752 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1171373008753 L-iditol 2-dehydrogenase; Region: iditol_2_DH_like; cd08235 1171373008754 putative NAD(P) binding site [chemical binding]; other site 1171373008755 catalytic Zn binding site [ion binding]; other site 1171373008756 proline/glycine betaine transporter; Provisional; Region: PRK10642 1171373008757 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1171373008758 putative substrate translocation pore; other site 1171373008759 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 1171373008760 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1171373008761 amidase catalytic site [active] 1171373008762 Zn binding residues [ion binding]; other site 1171373008763 substrate binding site [chemical binding]; other site 1171373008764 Predicted transcriptional regulator [Transcription]; Region: COG2345 1171373008765 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 1171373008766 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 1171373008767 PAS domain; Region: PAS_10; pfam13596 1171373008768 PAS domain; Region: PAS_10; pfam13596 1171373008769 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1171373008770 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1171373008771 dimer interface [polypeptide binding]; other site 1171373008772 conserved gate region; other site 1171373008773 putative PBP binding loops; other site 1171373008774 ABC-ATPase subunit interface; other site 1171373008775 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1171373008776 dimer interface [polypeptide binding]; other site 1171373008777 conserved gate region; other site 1171373008778 putative PBP binding loops; other site 1171373008779 ABC-ATPase subunit interface; other site 1171373008780 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1171373008781 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1171373008782 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1171373008783 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1171373008784 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 1171373008785 aromatic chitin/cellulose binding site residues [chemical binding]; other site 1171373008786 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 1171373008787 aromatic chitin/cellulose binding site residues [chemical binding]; other site 1171373008788 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1171373008789 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1171373008790 DNA binding site [nucleotide binding] 1171373008791 domain linker motif; other site 1171373008792 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1171373008793 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1171373008794 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1171373008795 Ca binding site [ion binding]; other site 1171373008796 active site 1171373008797 catalytic site [active] 1171373008798 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1171373008799 polynucleotide kinase; Provisional; Region: pseT; PHA02530 1171373008800 L-seryl-tRNA(Sec) kinase, eukaryotic; Region: selen_PSTK_euk; TIGR03575 1171373008801 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236 1171373008802 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 1171373008803 CH-type (Chalaropsis-type) lysozymes represent one of four functionally-defined classes of peptidoglycan hydrolases (also referred to as endo-N-acetylmuramidases) that cleave bacterial cell wall peptidoglycans. CH-type lysozymes exhibit both lysozyme; Region: GH25_CH-type; cd06412 1171373008804 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1171373008805 active site 1171373008806 LGFP repeat; Region: LGFP; pfam08310 1171373008807 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 1171373008808 This family represents an uncharacterized glycosyl hydrolase family 31 (GH31) enzyme found in bacteria and eukaryotes that is related to the XylS xylosidase of Sulfolobus solfataricus. Alpha-xylosidases catalyze the release of an alpha-xylose residue...; Region: GH31_xylosidase_XylS-like; cd06595 1171373008809 putative active site [active] 1171373008810 putative catalytic site [active] 1171373008811 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 1171373008812 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1171373008813 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1171373008814 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 1171373008815 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1171373008816 active site 1171373008817 catalytic site [active] 1171373008818 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1171373008819 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 1171373008820 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 1171373008821 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1171373008822 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1171373008823 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1171373008824 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1171373008825 dimer interface [polypeptide binding]; other site 1171373008826 conserved gate region; other site 1171373008827 putative PBP binding loops; other site 1171373008828 ABC-ATPase subunit interface; other site 1171373008829 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1171373008830 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1171373008831 dimer interface [polypeptide binding]; other site 1171373008832 conserved gate region; other site 1171373008833 putative PBP binding loops; other site 1171373008834 ABC-ATPase subunit interface; other site 1171373008835 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 1171373008836 MgtC family; Region: MgtC; pfam02308 1171373008837 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1171373008838 Carboxylesterase family; Region: COesterase; pfam00135 1171373008839 substrate binding pocket [chemical binding]; other site 1171373008840 catalytic triad [active] 1171373008841 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1171373008842 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1171373008843 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1171373008844 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1171373008845 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1171373008846 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1171373008847 dimer interface [polypeptide binding]; other site 1171373008848 conserved gate region; other site 1171373008849 putative PBP binding loops; other site 1171373008850 ABC-ATPase subunit interface; other site 1171373008851 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1171373008852 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1171373008853 dimer interface [polypeptide binding]; other site 1171373008854 conserved gate region; other site 1171373008855 putative PBP binding loops; other site 1171373008856 ABC-ATPase subunit interface; other site 1171373008857 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 1171373008858 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1171373008859 active site 1171373008860 catalytic site [active] 1171373008861 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1171373008862 NAD pyrophosphatase/5'-nucleotidase NadN; Region: nadN; TIGR01530 1171373008863 active site 1171373008864 metal binding site [ion binding]; metal-binding site 1171373008865 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1171373008866 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 1171373008867 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1171373008868 NAD binding site [chemical binding]; other site 1171373008869 ligand binding site [chemical binding]; other site 1171373008870 catalytic site [active] 1171373008871 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1171373008872 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1171373008873 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1171373008874 Walker A/P-loop; other site 1171373008875 ATP binding site [chemical binding]; other site 1171373008876 Q-loop/lid; other site 1171373008877 ABC transporter signature motif; other site 1171373008878 Walker B; other site 1171373008879 D-loop; other site 1171373008880 H-loop/switch region; other site 1171373008881 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1171373008882 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1171373008883 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1171373008884 Walker A/P-loop; other site 1171373008885 ATP binding site [chemical binding]; other site 1171373008886 Q-loop/lid; other site 1171373008887 ABC transporter signature motif; other site 1171373008888 Walker B; other site 1171373008889 D-loop; other site 1171373008890 H-loop/switch region; other site 1171373008891 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1171373008892 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1171373008893 active site 1171373008894 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 1171373008895 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1171373008896 Melibiase; Region: Melibiase; pfam02065 1171373008897 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 1171373008898 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 1171373008899 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1171373008900 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1171373008901 dimer interface [polypeptide binding]; other site 1171373008902 conserved gate region; other site 1171373008903 putative PBP binding loops; other site 1171373008904 ABC-ATPase subunit interface; other site 1171373008905 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1171373008906 dimer interface [polypeptide binding]; other site 1171373008907 conserved gate region; other site 1171373008908 putative PBP binding loops; other site 1171373008909 ABC-ATPase subunit interface; other site 1171373008910 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1171373008911 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1171373008912 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1171373008913 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1171373008914 DNA binding site [nucleotide binding] 1171373008915 domain linker motif; other site 1171373008916 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1171373008917 ligand binding site [chemical binding]; other site 1171373008918 dimerization interface [polypeptide binding]; other site 1171373008919 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E_like proteins; Region: GAT1_Peptidase_E_like; cd03129 1171373008920 catalytic triad [active] 1171373008921 active site nucleophile [active] 1171373008922 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1171373008923 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1171373008924 active site 1171373008925 phosphorylation site [posttranslational modification] 1171373008926 intermolecular recognition site; other site 1171373008927 dimerization interface [polypeptide binding]; other site 1171373008928 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1171373008929 DNA binding site [nucleotide binding] 1171373008930 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1171373008931 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1171373008932 dimerization interface [polypeptide binding]; other site 1171373008933 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1171373008934 dimer interface [polypeptide binding]; other site 1171373008935 phosphorylation site [posttranslational modification] 1171373008936 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1171373008937 ATP binding site [chemical binding]; other site 1171373008938 Mg2+ binding site [ion binding]; other site 1171373008939 G-X-G motif; other site 1171373008940 YibE/F-like protein; Region: YibE_F; pfam07907 1171373008941 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 1171373008942 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 1171373008943 active site 1171373008944 metal binding site [ion binding]; metal-binding site 1171373008945 nudix motif; other site 1171373008946 Colicin V production protein; Region: Colicin_V; pfam02674 1171373008947 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1171373008948 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1171373008949 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1171373008950 YCII-related domain; Region: YCII; cl00999 1171373008951 Protein of unknown function, DUF393; Region: DUF393; pfam04134 1171373008952 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1171373008953 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 1171373008954 active site 1171373008955 FMN binding site [chemical binding]; other site 1171373008956 substrate binding site [chemical binding]; other site 1171373008957 homotetramer interface [polypeptide binding]; other site 1171373008958 catalytic residue [active] 1171373008959 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1171373008960 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1171373008961 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1171373008962 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1171373008963 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1171373008964 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1171373008965 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1171373008966 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1171373008967 FAD binding pocket [chemical binding]; other site 1171373008968 FAD binding motif [chemical binding]; other site 1171373008969 phosphate binding motif [ion binding]; other site 1171373008970 NAD binding pocket [chemical binding]; other site 1171373008971 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 1171373008972 Ribosomal RNA adenine dimethylase; Region: RrnaAD; pfam00398 1171373008973 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1171373008974 S-adenosylmethionine binding site [chemical binding]; other site 1171373008975 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 1171373008976 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1171373008977 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1171373008978 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1171373008979 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1171373008980 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1171373008981 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1171373008982 dimer interface [polypeptide binding]; other site 1171373008983 ssDNA binding site [nucleotide binding]; other site 1171373008984 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1171373008985 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1171373008986 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 1171373008987 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 1171373008988 Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822 1171373008989 Imelysin; Region: Peptidase_M75; pfam09375 1171373008990 Iron permease FTR1 family; Region: FTR1; cl00475 1171373008991 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1171373008992 active site residue [active] 1171373008993 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1171373008994 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1171373008995 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1171373008996 acyl-activating enzyme (AAE) consensus motif; other site 1171373008997 putative AMP binding site [chemical binding]; other site 1171373008998 putative active site [active] 1171373008999 putative CoA binding site [chemical binding]; other site 1171373009000 endonuclease IV; Provisional; Region: PRK01060 1171373009001 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1171373009002 AP (apurinic/apyrimidinic) site pocket; other site 1171373009003 DNA interaction; other site 1171373009004 Metal-binding active site; metal-binding site 1171373009005 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1171373009006 classical (c) SDRs; Region: SDR_c; cd05233 1171373009007 NAD(P) binding site [chemical binding]; other site 1171373009008 active site 1171373009009 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1171373009010 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1171373009011 putative acyl-acceptor binding pocket; other site 1171373009012 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 1171373009013 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 1171373009014 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1171373009015 Alanine racemase, N-terminal domain; Region: Ala_racemase_N; pfam01168 1171373009016 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1171373009017 catalytic residue [active] 1171373009018 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 1171373009019 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1171373009020 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1171373009021 aminotransferase; Validated; Region: PRK07777 1171373009022 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1171373009023 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1171373009024 homodimer interface [polypeptide binding]; other site 1171373009025 catalytic residue [active] 1171373009026 FAD binding domain; Region: FAD_binding_4; pfam01565 1171373009027 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1171373009028 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1171373009029 Histidine kinase; Region: HisKA_3; pfam07730 1171373009030 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1171373009031 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1171373009032 active site 1171373009033 phosphorylation site [posttranslational modification] 1171373009034 intermolecular recognition site; other site 1171373009035 dimerization interface [polypeptide binding]; other site 1171373009036 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 1171373009037 DNA binding residues [nucleotide binding] 1171373009038 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 1171373009039 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1171373009040 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 1171373009041 Walker A/P-loop; other site 1171373009042 ATP binding site [chemical binding]; other site 1171373009043 Q-loop/lid; other site 1171373009044 ABC transporter signature motif; other site 1171373009045 Walker B; other site 1171373009046 D-loop; other site 1171373009047 H-loop/switch region; other site 1171373009048 bacteriocin-associated integral membrane (putative immunity) protein; Region: bact_immun_7tm; TIGR01654 1171373009049 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 1171373009050 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1171373009051 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 1171373009052 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1171373009053 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 1171373009054 Walker A/P-loop; other site 1171373009055 ATP binding site [chemical binding]; other site 1171373009056 Q-loop/lid; other site 1171373009057 ABC transporter signature motif; other site 1171373009058 Walker B; other site 1171373009059 D-loop; other site 1171373009060 H-loop/switch region; other site 1171373009061 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1171373009062 sn-glycerol-3-phosphate dehydrogenase subunit C; Provisional; Region: glpC; PRK11168 1171373009063 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 1171373009064 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1171373009065 glycerol-3-phosphate dehydrogenase, anaerobic, A subunit; Region: glycerol3P_GlpA; TIGR03377 1171373009066 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1171373009067 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1171373009068 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1171373009069 dimerization interface [polypeptide binding]; other site 1171373009070 ligand binding site [chemical binding]; other site 1171373009071 NADP binding site [chemical binding]; other site 1171373009072 catalytic site [active] 1171373009073 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1171373009074 MarR family; Region: MarR_2; pfam12802 1171373009075 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1171373009076 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 1171373009077 Cl- selectivity filter; other site 1171373009078 Cl- binding residues [ion binding]; other site 1171373009079 pore gating glutamate residue; other site 1171373009080 dimer interface [polypeptide binding]; other site 1171373009081 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1171373009082 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1171373009083 MarR family; Region: MarR_2; pfam12802 1171373009084 Uncharacterized conserved protein [Function unknown]; Region: COG2353 1171373009085 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1171373009086 active site 1171373009087 metal binding site [ion binding]; metal-binding site 1171373009088 DNA binding site [nucleotide binding] 1171373009089 Predicted ATPases [General function prediction only]; Region: COG1106 1171373009090 Uncharacterized conserved protein [Function unknown]; Region: COG4717 1171373009091 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1171373009092 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 1171373009093 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1171373009094 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1171373009095 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 1171373009096 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1171373009097 homodimer interface [polypeptide binding]; other site 1171373009098 substrate-cofactor binding pocket; other site 1171373009099 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1171373009100 catalytic residue [active] 1171373009101 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1171373009102 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1171373009103 substrate binding site [chemical binding]; other site 1171373009104 ATP binding site [chemical binding]; other site 1171373009105 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1171373009106 putative deacylase active site [active] 1171373009107 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1171373009108 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1171373009109 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1171373009110 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1171373009111 dimer interface [polypeptide binding]; other site 1171373009112 conserved gate region; other site 1171373009113 putative PBP binding loops; other site 1171373009114 ABC-ATPase subunit interface; other site 1171373009115 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1171373009116 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1171373009117 dimer interface [polypeptide binding]; other site 1171373009118 conserved gate region; other site 1171373009119 putative PBP binding loops; other site 1171373009120 ABC-ATPase subunit interface; other site 1171373009121 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1171373009122 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1171373009123 DNA binding site [nucleotide binding] 1171373009124 domain linker motif; other site 1171373009125 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1171373009126 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 1171373009127 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1171373009128 NAD(P) binding site [chemical binding]; other site 1171373009129 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1171373009130 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 1171373009131 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1171373009132 substrate binding [chemical binding]; other site 1171373009133 active site 1171373009134 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1171373009135 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1171373009136 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1171373009137 putative substrate binding site [chemical binding]; other site 1171373009138 putative ATP binding site [chemical binding]; other site 1171373009139 PemK-like protein; Region: PemK; pfam02452 1171373009140 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1171373009141 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1171373009142 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1171373009143 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 1171373009144 putative active site [active] 1171373009145 NAD synthetase; Reviewed; Region: nadE; PRK02628 1171373009146 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 1171373009147 multimer interface [polypeptide binding]; other site 1171373009148 active site 1171373009149 catalytic triad [active] 1171373009150 protein interface 1 [polypeptide binding]; other site 1171373009151 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1171373009152 homodimer interface [polypeptide binding]; other site 1171373009153 NAD binding pocket [chemical binding]; other site 1171373009154 ATP binding pocket [chemical binding]; other site 1171373009155 Mg binding site [ion binding]; other site 1171373009156 active-site loop [active] 1171373009157 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 1171373009158 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1171373009159 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1171373009160 phosphopeptide binding site; other site 1171373009161 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1171373009162 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1171373009163 phosphopeptide binding site; other site 1171373009164 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 1171373009165 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1171373009166 Walker A/P-loop; other site 1171373009167 ATP binding site [chemical binding]; other site 1171373009168 Q-loop/lid; other site 1171373009169 ABC transporter signature motif; other site 1171373009170 Walker B; other site 1171373009171 D-loop; other site 1171373009172 H-loop/switch region; other site 1171373009173 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1171373009174 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1171373009175 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1171373009176 active site 1171373009177 ATP binding site [chemical binding]; other site 1171373009178 substrate binding site [chemical binding]; other site 1171373009179 activation loop (A-loop); other site 1171373009180 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 1171373009181 6-phosphofructokinase, eukaryotic type; Region: 6PF1K_euk; TIGR02478 1171373009182 active site 1171373009183 ADP/pyrophosphate binding site [chemical binding]; other site 1171373009184 dimerization interface [polypeptide binding]; other site 1171373009185 allosteric effector site; other site 1171373009186 fructose-1,6-bisphosphate binding site; other site 1171373009187 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1171373009188 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1171373009189 hexamer interface [polypeptide binding]; other site 1171373009190 ligand binding site [chemical binding]; other site 1171373009191 putative active site [active] 1171373009192 NAD(P) binding site [chemical binding]; other site 1171373009193 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1171373009194 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1171373009195 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 1171373009196 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 1171373009197 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1171373009198 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 1171373009199 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1171373009200 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1171373009201 Bacterial SH3 domain; Region: SH3_3; pfam08239 1171373009202 Bacterial SH3 domain; Region: SH3_3; pfam08239 1171373009203 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 1171373009204 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1171373009205 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1171373009206 dimer interface [polypeptide binding]; other site 1171373009207 Citrate synthase; Region: Citrate_synt; pfam00285 1171373009208 active site 1171373009209 citrylCoA binding site [chemical binding]; other site 1171373009210 NADH binding [chemical binding]; other site 1171373009211 cationic pore residues; other site 1171373009212 oxalacetate/citrate binding site [chemical binding]; other site 1171373009213 coenzyme A binding site [chemical binding]; other site 1171373009214 catalytic triad [active] 1171373009215 adenosine deaminase; Provisional; Region: PRK09358 1171373009216 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1171373009217 active site 1171373009218 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1171373009219 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1171373009220 active site 1171373009221 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 1171373009222 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 1171373009223 active site 1171373009224 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 1171373009225 WYL domain; Region: WYL; pfam13280 1171373009226 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 1171373009227 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1171373009228 Cl- selectivity filter; other site 1171373009229 Cl- binding residues [ion binding]; other site 1171373009230 pore gating glutamate residue; other site 1171373009231 dimer interface [polypeptide binding]; other site 1171373009232 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 1171373009233 hypothetical protein; Validated; Region: PRK00194 1171373009234 ApbE family; Region: ApbE; pfam02424 1171373009235 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1171373009236 Class II fumarases; Region: Fumarase_classII; cd01362 1171373009237 active site 1171373009238 tetramer interface [polypeptide binding]; other site 1171373009239 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1171373009240 ThiC-associated domain; Region: ThiC-associated; pfam13667 1171373009241 ThiC family; Region: ThiC; pfam01964 1171373009242 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 1171373009243 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1171373009244 S-adenosylmethionine binding site [chemical binding]; other site 1171373009245 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1171373009246 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 1171373009247 trimer interface [polypeptide binding]; other site 1171373009248 active site 1171373009249 G bulge; other site 1171373009250 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1171373009251 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1171373009252 Walker A/P-loop; other site 1171373009253 ATP binding site [chemical binding]; other site 1171373009254 Q-loop/lid; other site 1171373009255 ABC transporter signature motif; other site 1171373009256 Walker B; other site 1171373009257 D-loop; other site 1171373009258 H-loop/switch region; other site 1171373009259 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1171373009260 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1171373009261 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1171373009262 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1171373009263 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1171373009264 putative substrate translocation pore; other site 1171373009265 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1171373009266 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1171373009267 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1171373009268 aspartate carbamoyltransferase; Provisional; Region: PRK08192 1171373009269 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1171373009270 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1171373009271 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1171373009272 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 1171373009273 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1171373009274 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1171373009275 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1171373009276 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1171373009277 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1171373009278 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 1171373009279 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1171373009280 active site 1171373009281 NTP binding site [chemical binding]; other site 1171373009282 metal binding triad [ion binding]; metal-binding site 1171373009283 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1171373009284 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1171373009285 Zn2+ binding site [ion binding]; other site 1171373009286 Mg2+ binding site [ion binding]; other site 1171373009287 succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407 1171373009288 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1171373009289 NAD(P) binding site [chemical binding]; other site 1171373009290 catalytic residues [active] 1171373009291 bile acid transporter; Region: bass; TIGR00841 1171373009292 Sodium Bile acid symporter family; Region: SBF; pfam01758 1171373009293 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1171373009294 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1171373009295 putative NAD(P) binding site [chemical binding]; other site 1171373009296 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 1171373009297 putative active site [active] 1171373009298 RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643 1171373009299 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1171373009300 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1171373009301 DNA binding residues [nucleotide binding] 1171373009302 glycerol kinase; Provisional; Region: glpK; PRK00047 1171373009303 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 1171373009304 N- and C-terminal domain interface [polypeptide binding]; other site 1171373009305 active site 1171373009306 MgATP binding site [chemical binding]; other site 1171373009307 catalytic site [active] 1171373009308 metal binding site [ion binding]; metal-binding site 1171373009309 putative homotetramer interface [polypeptide binding]; other site 1171373009310 glycerol binding site [chemical binding]; other site 1171373009311 homodimer interface [polypeptide binding]; other site 1171373009312 RAM signalling pathway protein; Region: SOG2; pfam10428 1171373009313 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 1171373009314 amphipathic channel; other site 1171373009315 Asn-Pro-Ala signature motifs; other site 1171373009316 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1171373009317 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1171373009318 DNA binding residues [nucleotide binding] 1171373009319 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1171373009320 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1171373009321 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1171373009322 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1171373009323 protein binding site [polypeptide binding]; other site 1171373009324 Glycosyl hydrolase family 43; Region: GH43_ABN_2; cd08999 1171373009325 putative substrate binding site [chemical binding]; other site 1171373009326 active site 1171373009327 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1171373009328 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1171373009329 dimer interface [polypeptide binding]; other site 1171373009330 conserved gate region; other site 1171373009331 putative PBP binding loops; other site 1171373009332 ABC-ATPase subunit interface; other site 1171373009333 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1171373009334 dimer interface [polypeptide binding]; other site 1171373009335 conserved gate region; other site 1171373009336 putative PBP binding loops; other site 1171373009337 ABC-ATPase subunit interface; other site 1171373009338 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1171373009339 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1171373009340 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 1171373009341 HNH/ENDO VII superfamily nuclease with conserved GHE residues; Region: GH-E; pfam14410 1171373009342 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 1171373009343 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1171373009344 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1171373009345 DNA binding site [nucleotide binding] 1171373009346 domain linker motif; other site 1171373009347 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1171373009348 ligand binding site [chemical binding]; other site 1171373009349 dimerization interface [polypeptide binding]; other site 1171373009350 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1171373009351 Predicted transcriptional regulators [Transcription]; Region: COG1733 1171373009352 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1171373009353 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1171373009354 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1171373009355 NAD(P) binding site [chemical binding]; other site 1171373009356 active site 1171373009357 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1171373009358 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1171373009359 active site 1171373009360 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1171373009361 catalytic residues [active] 1171373009362 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 1171373009363 Protein of unknown function (DUF4011); Region: DUF4011; pfam13195 1171373009364 Part of AAA domain; Region: AAA_19; pfam13245 1171373009365 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 1171373009366 AAA domain; Region: AAA_12; pfam13087 1171373009367 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1171373009368 ATP binding site [chemical binding]; other site 1171373009369 Mg2+ binding site [ion binding]; other site 1171373009370 G-X-G motif; other site 1171373009371 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1171373009372 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1171373009373 active site 1171373009374 phosphorylation site [posttranslational modification] 1171373009375 intermolecular recognition site; other site 1171373009376 dimerization interface [polypeptide binding]; other site 1171373009377 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1171373009378 DNA binding residues [nucleotide binding] 1171373009379 dimerization interface [polypeptide binding]; other site 1171373009380 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 1171373009381 putative active site [active] 1171373009382 transaldolase; Provisional; Region: PRK03903 1171373009383 catalytic residue [active] 1171373009384 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 1171373009385 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH10; cd08263 1171373009386 putative NAD(P) binding site [chemical binding]; other site 1171373009387 catalytic Zn binding site [ion binding]; other site 1171373009388 structural Zn binding site [ion binding]; other site 1171373009389 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1171373009390 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1171373009391 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1171373009392 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1171373009393 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1171373009394 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1171373009395 DNA binding site [nucleotide binding] 1171373009396 domain linker motif; other site 1171373009397 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1171373009398 dimerization interface [polypeptide binding]; other site 1171373009399 ligand binding site [chemical binding]; other site 1171373009400 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1171373009401 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1171373009402 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1171373009403 putative dimerization interface [polypeptide binding]; other site 1171373009404 Predicted membrane protein [Function unknown]; Region: COG2855 1171373009405 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1171373009406 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1171373009407 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1171373009408 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1171373009409 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1171373009410 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1171373009411 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1171373009412 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1171373009413 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1171373009414 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1171373009415 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1171373009416 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1171373009417 DNA binding site [nucleotide binding] 1171373009418 domain linker motif; other site 1171373009419 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1171373009420 dimerization interface [polypeptide binding]; other site 1171373009421 ligand binding site [chemical binding]; other site 1171373009422 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1171373009423 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1171373009424 putative substrate translocation pore; other site 1171373009425 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1171373009426 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1171373009427 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1171373009428 DNA binding site [nucleotide binding] 1171373009429 domain linker motif; other site 1171373009430 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1171373009431 ligand binding site [chemical binding]; other site 1171373009432 dimerization interface [polypeptide binding]; other site 1171373009433 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1171373009434 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1171373009435 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1171373009436 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1171373009437 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1171373009438 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1171373009439 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1171373009440 tetrameric interface [polypeptide binding]; other site 1171373009441 NAD binding site [chemical binding]; other site 1171373009442 catalytic residues [active] 1171373009443 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1171373009444 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1171373009445 DNA-binding site [nucleotide binding]; DNA binding site 1171373009446 UTRA domain; Region: UTRA; pfam07702 1171373009447 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1171373009448 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1171373009449 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1171373009450 homodimer interface [polypeptide binding]; other site 1171373009451 catalytic residue [active] 1171373009452 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 1171373009453 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1171373009454 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1171373009455 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 1171373009456 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 1171373009457 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 1171373009458 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1171373009459 ParB-like nuclease domain; Region: ParBc; pfam02195 1171373009460 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 1171373009461 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1171373009462 P-loop; other site 1171373009463 Magnesium ion binding site [ion binding]; other site 1171373009464 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1171373009465 Magnesium ion binding site [ion binding]; other site 1171373009466 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1171373009467 MULE transposase domain; Region: MULE; pfam10551 1171373009468 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1171373009469 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 1171373009470 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1171373009471 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 1171373009472 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1171373009473 G-X-X-G motif; other site 1171373009474 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1171373009475 RxxxH motif; other site 1171373009476 putative inner membrane protein translocase component YidC; Provisional; Region: PRK01315 1171373009477 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 1171373009478 Haemolytic domain; Region: Haemolytic; pfam01809 1171373009479 Ribonuclease P; Region: Ribonuclease_P; pfam00825