-- dump date 20140620_000623 -- class Genbank::misc_feature -- table misc_feature_note -- id note 909952000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 909952000002 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 909952000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 909952000004 Walker A motif; other site 909952000005 ATP binding site [chemical binding]; other site 909952000006 Walker B motif; other site 909952000007 arginine finger; other site 909952000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 909952000009 DnaA box-binding interface [nucleotide binding]; other site 909952000010 DNA polymerase III subunit beta; Validated; Region: PRK07761 909952000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 909952000012 putative DNA binding surface [nucleotide binding]; other site 909952000013 dimer interface [polypeptide binding]; other site 909952000014 beta-clamp/clamp loader binding surface; other site 909952000015 beta-clamp/translesion DNA polymerase binding surface; other site 909952000016 recombination protein F; Reviewed; Region: recF; PRK00064 909952000017 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 909952000018 Walker A/P-loop; other site 909952000019 ATP binding site [chemical binding]; other site 909952000020 Q-loop/lid; other site 909952000021 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 909952000022 ABC transporter signature motif; other site 909952000023 Walker B; other site 909952000024 D-loop; other site 909952000025 H-loop/switch region; other site 909952000026 Protein of unknown function (DUF721); Region: DUF721; cl02324 909952000027 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 909952000028 ABC transporter signature motif; other site 909952000029 Walker B; other site 909952000030 D-loop; other site 909952000031 H-loop/switch region; other site 909952000032 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 909952000033 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 909952000034 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 909952000035 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 909952000036 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 909952000037 Mg2+ binding site [ion binding]; other site 909952000038 G-X-G motif; other site 909952000039 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 909952000040 anchoring element; other site 909952000041 dimer interface [polypeptide binding]; other site 909952000042 ATP binding site [chemical binding]; other site 909952000043 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 909952000044 active site 909952000045 putative metal-binding site [ion binding]; other site 909952000046 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 909952000047 DNA gyrase subunit A; Validated; Region: PRK05560 909952000048 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 909952000049 CAP-like domain; other site 909952000050 active site 909952000051 primary dimer interface [polypeptide binding]; other site 909952000052 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 909952000053 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 909952000054 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 909952000055 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 909952000056 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 909952000057 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 909952000058 A subgroup of L-lactate dehydrogenases; Region: LDH_3; cd05290 909952000059 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 909952000060 NAD binding site [chemical binding]; other site 909952000061 dimer interface [polypeptide binding]; other site 909952000062 tetramer (dimer of dimers) interface [polypeptide binding]; other site 909952000063 substrate binding site [chemical binding]; other site 909952000064 Transcriptional regulators [Transcription]; Region: PurR; COG1609 909952000065 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 909952000066 DNA binding site [nucleotide binding] 909952000067 domain linker motif; other site 909952000068 Ligand-binding domain of DNA-binding regulatory protein from Corynebacterium glutamicum which has a unique ability to produce significant amounts of L-glutamate directly from cheap sugar and ammonia; Region: PBP1_LacI_like_13; cd06299 909952000069 dimerization interface [polypeptide binding]; other site 909952000070 putative ligand binding site [chemical binding]; other site 909952000071 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 909952000072 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 909952000073 Walker A/P-loop; other site 909952000074 ATP binding site [chemical binding]; other site 909952000075 Q-loop/lid; other site 909952000076 ABC transporter signature motif; other site 909952000077 Walker B; other site 909952000078 D-loop; other site 909952000079 H-loop/switch region; other site 909952000080 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 909952000081 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 909952000082 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 909952000083 TM-ABC transporter signature motif; other site 909952000084 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 909952000085 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 909952000086 ligand binding site [chemical binding]; other site 909952000087 dimerization interface [polypeptide binding]; other site 909952000088 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 909952000089 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 909952000090 substrate binding site [chemical binding]; other site 909952000091 dimer interface [polypeptide binding]; other site 909952000092 ATP binding site [chemical binding]; other site 909952000093 D-ribose pyranase; Provisional; Region: PRK11797 909952000094 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 909952000095 active site 909952000096 phosphorylation site [posttranslational modification] 909952000097 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 909952000098 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 909952000099 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 909952000100 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 909952000101 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 909952000102 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 909952000103 HTH domain; Region: HTH_11; cl17392 909952000104 PRD domain; Region: PRD; pfam00874 909952000105 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359 909952000106 active site 909952000107 phosphorylation site [posttranslational modification] 909952000108 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 909952000109 putative phosphatase; Provisional; Region: PRK11587 909952000110 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 909952000111 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 909952000112 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 909952000113 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 909952000114 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 909952000115 pyridoxal 5'-phosphate binding site [chemical binding]; other site 909952000116 homodimer interface [polypeptide binding]; other site 909952000117 catalytic residue [active] 909952000118 potential frameshift: common BLAST hit: gi|365972952|ref|YP_004954511.1| phospholipase 909952000119 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 909952000120 active site 909952000121 nucleophile elbow; other site 909952000122 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 909952000123 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 909952000124 Coenzyme A binding pocket [chemical binding]; other site 909952000125 SAF domain; Region: SAF; pfam08666 909952000126 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 909952000127 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 909952000128 Walker A motif; other site 909952000129 ATP binding site [chemical binding]; other site 909952000130 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 909952000131 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 909952000132 Bacterial transcriptional activator domain; Region: BTAD; smart01043 909952000133 H+ Antiporter protein; Region: 2A0121; TIGR00900 909952000134 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 909952000135 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 909952000136 Potassium binding sites [ion binding]; other site 909952000137 Cesium cation binding sites [ion binding]; other site 909952000138 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 909952000139 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 909952000140 FtsX-like permease family; Region: FtsX; pfam02687 909952000141 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 909952000142 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 909952000143 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 909952000144 Walker A/P-loop; other site 909952000145 ATP binding site [chemical binding]; other site 909952000146 Q-loop/lid; other site 909952000147 ABC transporter signature motif; other site 909952000148 Walker B; other site 909952000149 D-loop; other site 909952000150 H-loop/switch region; other site 909952000151 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 909952000152 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 909952000153 active site 909952000154 phosphorylation site [posttranslational modification] 909952000155 intermolecular recognition site; other site 909952000156 dimerization interface [polypeptide binding]; other site 909952000157 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 909952000158 DNA binding residues [nucleotide binding] 909952000159 dimerization interface [polypeptide binding]; other site 909952000160 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 909952000161 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 909952000162 dimer interface [polypeptide binding]; other site 909952000163 conserved gate region; other site 909952000164 putative PBP binding loops; other site 909952000165 ABC-ATPase subunit interface; other site 909952000166 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 909952000167 dimer interface [polypeptide binding]; other site 909952000168 conserved gate region; other site 909952000169 putative PBP binding loops; other site 909952000170 ABC-ATPase subunit interface; other site 909952000171 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 909952000172 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 909952000173 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 909952000174 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 909952000175 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 909952000176 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 909952000177 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 909952000178 NAD binding site [chemical binding]; other site 909952000179 sugar binding site [chemical binding]; other site 909952000180 divalent metal binding site [ion binding]; other site 909952000181 tetramer (dimer of dimers) interface [polypeptide binding]; other site 909952000182 dimer interface [polypeptide binding]; other site 909952000183 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 909952000184 active site 909952000185 catalytic site [active] 909952000186 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 909952000187 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 909952000188 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 909952000189 Sulfatase; Region: Sulfatase; cl17466 909952000190 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 909952000191 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 909952000192 motif II; other site 909952000193 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 909952000194 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 909952000195 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 909952000196 active site 909952000197 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 909952000198 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 909952000199 substrate binding site [chemical binding]; other site 909952000200 ATP binding site [chemical binding]; other site 909952000201 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 909952000202 Histidine kinase; Region: HisKA_3; pfam07730 909952000203 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 909952000204 ATP binding site [chemical binding]; other site 909952000205 Mg2+ binding site [ion binding]; other site 909952000206 G-X-G motif; other site 909952000207 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 909952000208 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 909952000209 NAD(P) binding site [chemical binding]; other site 909952000210 active site 909952000211 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 909952000212 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 909952000213 MMPL family; Region: MMPL; pfam03176 909952000214 MMPL family; Region: MMPL; pfam03176 909952000215 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 909952000216 Predicted membrane protein [Function unknown]; Region: COG1511 909952000217 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 909952000218 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 909952000219 Walker A/P-loop; other site 909952000220 ATP binding site [chemical binding]; other site 909952000221 Q-loop/lid; other site 909952000222 ABC transporter signature motif; other site 909952000223 Walker B; other site 909952000224 D-loop; other site 909952000225 H-loop/switch region; other site 909952000226 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 909952000227 S-adenosylmethionine binding site [chemical binding]; other site 909952000228 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 909952000229 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 909952000230 putative ligand binding residues [chemical binding]; other site 909952000231 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 909952000232 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 909952000233 ABC-ATPase subunit interface; other site 909952000234 dimer interface [polypeptide binding]; other site 909952000235 putative PBP binding regions; other site 909952000236 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 909952000237 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 909952000238 Walker A/P-loop; other site 909952000239 ATP binding site [chemical binding]; other site 909952000240 Q-loop/lid; other site 909952000241 ABC transporter signature motif; other site 909952000242 Walker B; other site 909952000243 D-loop; other site 909952000244 H-loop/switch region; other site 909952000245 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 909952000246 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 909952000247 tetramerization interface [polypeptide binding]; other site 909952000248 NAD(P) binding site [chemical binding]; other site 909952000249 catalytic residues [active] 909952000250 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 909952000251 Putative ClC chloride channel. Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033 909952000252 putative ion selectivity filter; other site 909952000253 putative pore gating glutamate residue; other site 909952000254 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 909952000255 homodimer interface [polypeptide binding]; other site 909952000256 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 909952000257 active site pocket [active] 909952000258 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 909952000259 DNA binding residues [nucleotide binding] 909952000260 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase; Region: TIGR02336 909952000261 Lacto-N-biose phosphorylase; Region: Lact_bio_phlase; pfam09508 909952000262 MarR family; Region: MarR_2; pfam12802 909952000263 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 909952000264 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 909952000265 carbohydrate ABC transporter substrate-binding protein, CPR_0540 family; Region: bind_CPR_0540; TIGR03850 909952000266 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 909952000267 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 909952000268 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 909952000269 dimer interface [polypeptide binding]; other site 909952000270 conserved gate region; other site 909952000271 putative PBP binding loops; other site 909952000272 ABC-ATPase subunit interface; other site 909952000273 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 909952000274 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 909952000275 dimer interface [polypeptide binding]; other site 909952000276 conserved gate region; other site 909952000277 putative PBP binding loops; other site 909952000278 ABC-ATPase subunit interface; other site 909952000279 Transcriptional regulators [Transcription]; Region: PurR; COG1609 909952000280 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 909952000281 DNA binding site [nucleotide binding] 909952000282 domain linker motif; other site 909952000283 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 909952000284 ligand binding site [chemical binding]; other site 909952000285 dimerization interface (open form) [polypeptide binding]; other site 909952000286 dimerization interface (closed form) [polypeptide binding]; other site 909952000287 6-phosphofructokinase; Provisional; Region: PRK03202 909952000288 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 909952000289 active site 909952000290 ADP/pyrophosphate binding site [chemical binding]; other site 909952000291 dimerization interface [polypeptide binding]; other site 909952000292 allosteric effector site; other site 909952000293 fructose-1,6-bisphosphate binding site; other site 909952000294 Predicted transcriptional regulator [Transcription]; Region: COG2345 909952000295 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 909952000296 putative DNA binding site [nucleotide binding]; other site 909952000297 putative Zn2+ binding site [ion binding]; other site 909952000298 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 909952000299 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 909952000300 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 909952000301 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 909952000302 Aspartase; Region: Aspartase; cd01357 909952000303 active sites [active] 909952000304 tetramer interface [polypeptide binding]; other site 909952000305 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 909952000306 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 909952000307 Predicted acetyltransferase [General function prediction only]; Region: COG2388 909952000308 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 909952000309 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 909952000310 heme binding pocket [chemical binding]; other site 909952000311 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 909952000312 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 909952000313 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 909952000314 Walker A/P-loop; other site 909952000315 ATP binding site [chemical binding]; other site 909952000316 Q-loop/lid; other site 909952000317 ABC transporter signature motif; other site 909952000318 Walker B; other site 909952000319 D-loop; other site 909952000320 H-loop/switch region; other site 909952000321 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 909952000322 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 909952000323 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 909952000324 Q-loop/lid; other site 909952000325 ABC transporter signature motif; other site 909952000326 Walker B; other site 909952000327 D-loop; other site 909952000328 H-loop/switch region; other site 909952000329 Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081 909952000330 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 909952000331 Walker A motif; other site 909952000332 ATP binding site [chemical binding]; other site 909952000333 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 909952000334 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 909952000335 Walker A motif; other site 909952000336 ATP binding site [chemical binding]; other site 909952000337 Walker B motif; other site 909952000338 arginine finger; other site 909952000339 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 909952000340 metal ion-dependent adhesion site (MIDAS); other site 909952000341 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 909952000342 CobN/Magnesium Chelatase; Region: CobN-Mg_chel; pfam02514 909952000343 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 909952000344 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 909952000345 Radical SAM superfamily; Region: Radical_SAM; pfam04055 909952000346 FeS/SAM binding site; other site 909952000347 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 909952000348 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 909952000349 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 909952000350 Walker A/P-loop; other site 909952000351 ATP binding site [chemical binding]; other site 909952000352 Q-loop/lid; other site 909952000353 ABC transporter signature motif; other site 909952000354 Walker B; other site 909952000355 D-loop; other site 909952000356 H-loop/switch region; other site 909952000357 FecCD transport family; Region: FecCD; pfam01032 909952000358 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 909952000359 ABC-ATPase subunit interface; other site 909952000360 dimer interface [polypeptide binding]; other site 909952000361 putative PBP binding regions; other site 909952000362 Periplasmic binding protein TroA_d. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_d; cd01141 909952000363 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 909952000364 putative ligand binding site [chemical binding]; other site 909952000365 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 909952000366 Periplasmic binding protein TroA_d. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_d; cd01141 909952000367 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 909952000368 putative ligand binding site [chemical binding]; other site 909952000369 AIR synthase related protein, N-terminal domain; Region: AIRS; pfam00586 909952000370 myosin-cross-reactive antigen; Provisional; Region: PRK13977 909952000371 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 909952000372 thiamine phosphate binding site [chemical binding]; other site 909952000373 active site 909952000374 pyrophosphate binding site [ion binding]; other site 909952000375 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 909952000376 putative active site [active] 909952000377 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 909952000378 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 909952000379 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 909952000380 Soluble P-type ATPase [General function prediction only]; Region: COG4087 909952000381 K+-transporting ATPase, c chain; Region: KdpC; cl00944 909952000382 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 909952000383 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 909952000384 Ligand Binding Site [chemical binding]; other site 909952000385 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 909952000386 dimer interface [polypeptide binding]; other site 909952000387 phosphorylation site [posttranslational modification] 909952000388 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 909952000389 ATP binding site [chemical binding]; other site 909952000390 Mg2+ binding site [ion binding]; other site 909952000391 G-X-G motif; other site 909952000392 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 909952000393 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 909952000394 active site 909952000395 phosphorylation site [posttranslational modification] 909952000396 intermolecular recognition site; other site 909952000397 dimerization interface [polypeptide binding]; other site 909952000398 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 909952000399 DNA binding site [nucleotide binding] 909952000400 EXLDI protein; Region: EXLDI; TIGR04342 909952000401 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 909952000402 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 909952000403 potential frameshift: common BLAST hit: gi|365964097|ref|YP_004945662.1| peptidase, M16 (pitrilysin) family protein 909952000404 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 909952000405 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 909952000406 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 909952000407 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 909952000408 Transglycosylase; Region: Transgly; pfam00912 909952000409 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 909952000410 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 909952000411 Mannosyltransferase (PIG-V)); Region: Mannosyl_trans2; pfam04188 909952000412 This family is most closely related to the GT1 family of glycosyltransferases. AmsK is involved in the biosynthesis of amylovoran, which functions as a virulence factor. It functions as a glycosyl transferase which transfers galactose from UDP-galactose...; Region: GT1_AmsK_like; cd04946 909952000413 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 909952000414 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 909952000415 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 909952000416 O-Antigen ligase; Region: Wzy_C; pfam04932 909952000417 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 909952000418 putative trimer interface [polypeptide binding]; other site 909952000419 putative CoA binding site [chemical binding]; other site 909952000420 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 909952000421 putative trimer interface [polypeptide binding]; other site 909952000422 putative active site [active] 909952000423 putative substrate binding site [chemical binding]; other site 909952000424 putative CoA binding site [chemical binding]; other site 909952000425 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 909952000426 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 909952000427 inhibitor-cofactor binding pocket; inhibition site 909952000428 pyridoxal 5'-phosphate binding site [chemical binding]; other site 909952000429 catalytic residue [active] 909952000430 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 909952000431 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 909952000432 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 909952000433 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 909952000434 O-Antigen ligase; Region: Wzy_C; pfam04932 909952000435 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 909952000436 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909952000437 putative substrate translocation pore; other site 909952000438 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 909952000439 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 909952000440 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 909952000441 classical (c) SDRs; Region: SDR_c; cd05233 909952000442 NAD(P) binding site [chemical binding]; other site 909952000443 active site 909952000444 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 909952000445 dimerization domain swap beta strand [polypeptide binding]; other site 909952000446 regulatory protein interface [polypeptide binding]; other site 909952000447 active site 909952000448 regulatory phosphorylation site [posttranslational modification]; other site 909952000449 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 909952000450 active site 909952000451 phosphorylation site [posttranslational modification] 909952000452 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 909952000453 active site 909952000454 P-loop; other site 909952000455 phosphorylation site [posttranslational modification] 909952000456 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 909952000457 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 909952000458 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 909952000459 putative substrate binding site [chemical binding]; other site 909952000460 putative ATP binding site [chemical binding]; other site 909952000461 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 909952000462 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 909952000463 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 909952000464 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 909952000465 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 909952000466 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 909952000467 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 909952000468 O-Antigen ligase; Region: Wzy_C; pfam04932 909952000469 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 909952000470 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 909952000471 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 909952000472 active site 909952000473 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 909952000474 homodimer interface [polypeptide binding]; other site 909952000475 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 909952000476 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 909952000477 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 909952000478 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 909952000479 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 909952000480 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 909952000481 nudix motif; other site 909952000482 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 909952000483 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 909952000484 ATP binding site [chemical binding]; other site 909952000485 putative Mg++ binding site [ion binding]; other site 909952000486 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 909952000487 nucleotide binding region [chemical binding]; other site 909952000488 ATP-binding site [chemical binding]; other site 909952000489 Helicase associated domain (HA2); Region: HA2; pfam04408 909952000490 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 909952000491 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 909952000492 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 909952000493 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 909952000494 Walker A/P-loop; other site 909952000495 ATP binding site [chemical binding]; other site 909952000496 Q-loop/lid; other site 909952000497 ABC transporter signature motif; other site 909952000498 Walker B; other site 909952000499 D-loop; other site 909952000500 H-loop/switch region; other site 909952000501 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 909952000502 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 909952000503 Walker A/P-loop; other site 909952000504 ATP binding site [chemical binding]; other site 909952000505 Q-loop/lid; other site 909952000506 ABC transporter signature motif; other site 909952000507 Walker B; other site 909952000508 D-loop; other site 909952000509 H-loop/switch region; other site 909952000510 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 909952000511 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 909952000512 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 909952000513 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565 909952000514 Dihydroorotate dehydrogenase (DHOD) like proteins. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_like; cd04739 909952000515 putative active site [active] 909952000516 putative FMN binding site [chemical binding]; other site 909952000517 putative substrate binding site [chemical binding]; other site 909952000518 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 909952000519 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 909952000520 dimer interface [polypeptide binding]; other site 909952000521 PYR/PP interface [polypeptide binding]; other site 909952000522 TPP binding site [chemical binding]; other site 909952000523 substrate binding site [chemical binding]; other site 909952000524 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 909952000525 Domain of unknown function; Region: EKR; smart00890 909952000526 4Fe-4S binding domain; Region: Fer4_6; pfam12837 909952000527 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 909952000528 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 909952000529 TPP-binding site [chemical binding]; other site 909952000530 dimer interface [polypeptide binding]; other site 909952000531 putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771 909952000532 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 909952000533 4Fe-4S binding domain; Region: Fer4; pfam00037 909952000534 Domain of unknown function DUF77; Region: DUF77; pfam01910 909952000535 Transcriptional regulators [Transcription]; Region: FadR; COG2186 909952000536 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 909952000537 DNA-binding site [nucleotide binding]; DNA binding site 909952000538 L-lactate permease; Region: Lactate_perm; cl00701 909952000539 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 909952000540 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 909952000541 Cysteine-rich domain; Region: CCG; pfam02754 909952000542 Cysteine-rich domain; Region: CCG; pfam02754 909952000543 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 909952000544 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 909952000545 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 909952000546 Uncharacterized conserved protein [Function unknown]; Region: COG1556 909952000547 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 909952000548 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 909952000549 Walker A/P-loop; other site 909952000550 ATP binding site [chemical binding]; other site 909952000551 Q-loop/lid; other site 909952000552 ABC transporter signature motif; other site 909952000553 Walker B; other site 909952000554 D-loop; other site 909952000555 H-loop/switch region; other site 909952000556 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 909952000557 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 909952000558 Walker A/P-loop; other site 909952000559 ATP binding site [chemical binding]; other site 909952000560 Q-loop/lid; other site 909952000561 ABC transporter signature motif; other site 909952000562 Walker B; other site 909952000563 D-loop; other site 909952000564 H-loop/switch region; other site 909952000565 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 909952000566 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 909952000567 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 909952000568 Walker A/P-loop; other site 909952000569 ATP binding site [chemical binding]; other site 909952000570 Q-loop/lid; other site 909952000571 ABC transporter signature motif; other site 909952000572 Walker B; other site 909952000573 D-loop; other site 909952000574 H-loop/switch region; other site 909952000575 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 909952000576 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 909952000577 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 909952000578 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 909952000579 Amino acid permease; Region: AA_permease_2; pfam13520 909952000580 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 909952000581 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 909952000582 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 909952000583 Walker A/P-loop; other site 909952000584 ATP binding site [chemical binding]; other site 909952000585 Q-loop/lid; other site 909952000586 ABC transporter signature motif; other site 909952000587 Walker B; other site 909952000588 D-loop; other site 909952000589 H-loop/switch region; other site 909952000590 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 909952000591 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 909952000592 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 909952000593 Walker A/P-loop; other site 909952000594 ATP binding site [chemical binding]; other site 909952000595 Q-loop/lid; other site 909952000596 ABC transporter signature motif; other site 909952000597 Walker B; other site 909952000598 D-loop; other site 909952000599 H-loop/switch region; other site 909952000600 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 909952000601 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 909952000602 non-specific DNA binding site [nucleotide binding]; other site 909952000603 salt bridge; other site 909952000604 sequence-specific DNA binding site [nucleotide binding]; other site 909952000605 Domain of unknown function (DUF955); Region: DUF955; pfam06114 909952000606 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 909952000607 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 909952000608 dimer interface [polypeptide binding]; other site 909952000609 putative anticodon binding site; other site 909952000610 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 909952000611 motif 1; other site 909952000612 dimer interface [polypeptide binding]; other site 909952000613 active site 909952000614 motif 2; other site 909952000615 motif 3; other site 909952000616 Uncharacterized protein family (UPF0233); Region: UPF0233; pfam06781 909952000617 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 909952000618 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 909952000619 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 909952000620 active site 909952000621 ATP binding site [chemical binding]; other site 909952000622 substrate binding site [chemical binding]; other site 909952000623 activation loop (A-loop); other site 909952000624 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 909952000625 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 909952000626 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 909952000627 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 909952000628 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 909952000629 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 909952000630 active site 909952000631 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 909952000632 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 909952000633 phosphopeptide binding site; other site 909952000634 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 909952000635 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 909952000636 phosphopeptide binding site; other site 909952000637 Phosphotransferase enzyme family; Region: APH; pfam01636 909952000638 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 909952000639 active site 909952000640 ATP binding site [chemical binding]; other site 909952000641 RHS Repeat; Region: RHS_repeat; pfam05593 909952000642 RHS Repeat; Region: RHS_repeat; cl11982 909952000643 RHS Repeat; Region: RHS_repeat; cl11982 909952000644 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 909952000645 RHS Repeat; Region: RHS_repeat; pfam05593 909952000646 RHS Repeat; Region: RHS_repeat; pfam05593 909952000647 RHS Repeat; Region: RHS_repeat; pfam05593 909952000648 RHS Repeat; Region: RHS_repeat; pfam05593 909952000649 RHS Repeat; Region: RHS_repeat; cl11982 909952000650 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 909952000651 RHS Repeat; Region: RHS_repeat; cl11982 909952000652 RHS Repeat; Region: RHS_repeat; cl11982 909952000653 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 909952000654 RHS Repeat; Region: RHS_repeat; pfam05593 909952000655 RHS Repeat; Region: RHS_repeat; pfam05593 909952000656 RHS Repeat; Region: RHS_repeat; pfam05593 909952000657 RHS Repeat; Region: RHS_repeat; pfam05593 909952000658 RHS Repeat; Region: RHS_repeat; cl11982 909952000659 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 909952000660 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 909952000661 RNA binding surface [nucleotide binding]; other site 909952000662 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 909952000663 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 909952000664 Walker A motif; other site 909952000665 ATP binding site [chemical binding]; other site 909952000666 Walker B motif; other site 909952000667 arginine finger; other site 909952000668 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 909952000669 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 909952000670 recombination protein RecR; Reviewed; Region: recR; PRK00076 909952000671 RecR protein; Region: RecR; pfam02132 909952000672 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 909952000673 putative active site [active] 909952000674 putative metal-binding site [ion binding]; other site 909952000675 tetramer interface [polypeptide binding]; other site 909952000676 Predicted transcriptional regulators [Transcription]; Region: COG1695 909952000677 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 909952000678 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 909952000679 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 909952000680 Walker A/P-loop; other site 909952000681 ATP binding site [chemical binding]; other site 909952000682 Q-loop/lid; other site 909952000683 ABC transporter signature motif; other site 909952000684 Walker B; other site 909952000685 D-loop; other site 909952000686 H-loop/switch region; other site 909952000687 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 909952000688 Uncharacterized conserved protein [Function unknown]; Region: COG2966 909952000689 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 909952000690 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 909952000691 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 909952000692 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 909952000693 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 909952000694 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 909952000695 active site 909952000696 motif I; other site 909952000697 motif II; other site 909952000698 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 909952000699 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 909952000700 Walker A/P-loop; other site 909952000701 ATP binding site [chemical binding]; other site 909952000702 Q-loop/lid; other site 909952000703 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 909952000704 ABC transporter signature motif; other site 909952000705 Walker B; other site 909952000706 D-loop; other site 909952000707 H-loop/switch region; other site 909952000708 Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060 909952000709 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 909952000710 active site 909952000711 HIGH motif; other site 909952000712 nucleotide binding site [chemical binding]; other site 909952000713 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 909952000714 active site 909952000715 KMSKS motif; other site 909952000716 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 909952000717 tRNA binding surface [nucleotide binding]; other site 909952000718 anticodon binding site; other site 909952000719 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 909952000720 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 909952000721 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 909952000722 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 909952000723 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 909952000724 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 909952000725 Transcription factor WhiB; Region: Whib; pfam02467 909952000726 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 909952000727 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 909952000728 homotrimer interaction site [polypeptide binding]; other site 909952000729 putative active site [active] 909952000730 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 909952000731 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 909952000732 ligand binding site [chemical binding]; other site 909952000733 flexible hinge region; other site 909952000734 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 909952000735 putative switch regulator; other site 909952000736 non-specific DNA interactions [nucleotide binding]; other site 909952000737 DNA binding site [nucleotide binding] 909952000738 sequence specific DNA binding site [nucleotide binding]; other site 909952000739 putative cAMP binding site [chemical binding]; other site 909952000740 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 909952000741 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 909952000742 minor groove reading motif; other site 909952000743 helix-hairpin-helix signature motif; other site 909952000744 substrate binding pocket [chemical binding]; other site 909952000745 active site 909952000746 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 909952000747 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 909952000748 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 909952000749 catalytic residues [active] 909952000750 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 909952000751 putative active site [active] 909952000752 putative CoA binding site [chemical binding]; other site 909952000753 nudix motif; other site 909952000754 metal binding site [ion binding]; metal-binding site 909952000755 pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14853 909952000756 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 909952000757 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 909952000758 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 909952000759 helicase/secretion neighborhood ATPase; Region: heli_sec_ATPase; TIGR03819 909952000760 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 909952000761 Walker A motif; other site 909952000762 ATP binding site [chemical binding]; other site 909952000763 Walker B motif; other site 909952000764 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 909952000765 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 909952000766 helicase/secretion neighborhood TadE-like protein; Region: tadE_like_DECH; TIGR03816 909952000767 Predicted ATPase [General function prediction only]; Region: COG4637 909952000768 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 909952000769 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 909952000770 ATP binding site [chemical binding]; other site 909952000771 putative Mg++ binding site [ion binding]; other site 909952000772 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 909952000773 nucleotide binding region [chemical binding]; other site 909952000774 ATP-binding site [chemical binding]; other site 909952000775 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 909952000776 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 909952000777 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 909952000778 S-adenosylmethionine binding site [chemical binding]; other site 909952000779 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 909952000780 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 909952000781 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 909952000782 active site 909952000783 interdomain interaction site; other site 909952000784 putative metal-binding site [ion binding]; other site 909952000785 nucleotide binding site [chemical binding]; other site 909952000786 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 909952000787 domain I; other site 909952000788 DNA binding groove [nucleotide binding] 909952000789 phosphate binding site [ion binding]; other site 909952000790 domain II; other site 909952000791 domain III; other site 909952000792 nucleotide binding site [chemical binding]; other site 909952000793 catalytic site [active] 909952000794 domain IV; other site 909952000795 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 909952000796 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 909952000797 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 909952000798 thymidylate kinase; Validated; Region: tmk; PRK00698 909952000799 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 909952000800 TMP-binding site; other site 909952000801 ATP-binding site [chemical binding]; other site 909952000802 DNA polymerase III subunit delta'; Validated; Region: PRK07940 909952000803 DNA polymerase III subunit delta'; Validated; Region: PRK08485 909952000804 Predicted membrane protein [Function unknown]; Region: COG2259 909952000805 PSP1 C-terminal conserved region; Region: PSP1; cl00770 909952000806 TAP-like protein; Region: Abhydrolase_4; pfam08386 909952000807 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 909952000808 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 909952000809 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 909952000810 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 909952000811 catalytic core [active] 909952000812 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 909952000813 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 909952000814 Methyltransferase domain; Region: Methyltransf_26; pfam13659 909952000815 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 909952000816 dimer interface [polypeptide binding]; other site 909952000817 substrate binding site [chemical binding]; other site 909952000818 metal binding sites [ion binding]; metal-binding site 909952000819 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 909952000820 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 909952000821 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 909952000822 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 909952000823 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 909952000824 Ligand Binding Site [chemical binding]; other site 909952000825 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 909952000826 active site 909952000827 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 909952000828 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 909952000829 Walker A motif; other site 909952000830 ATP binding site [chemical binding]; other site 909952000831 Walker B motif; other site 909952000832 arginine finger; other site 909952000833 Peptidase family M41; Region: Peptidase_M41; pfam01434 909952000834 Protein of unknown function (DUF3729); Region: DUF3729; pfam12526 909952000835 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 909952000836 homodecamer interface [polypeptide binding]; other site 909952000837 GTP cyclohydrolase I; Provisional; Region: PLN03044 909952000838 active site 909952000839 putative catalytic site residues [active] 909952000840 zinc binding site [ion binding]; other site 909952000841 GTP-CH-I/GFRP interaction surface; other site 909952000842 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 909952000843 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 909952000844 ligand binding site [chemical binding]; other site 909952000845 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 909952000846 dihydropteroate synthase; Region: DHPS; TIGR01496 909952000847 substrate binding pocket [chemical binding]; other site 909952000848 dimer interface [polypeptide binding]; other site 909952000849 inhibitor binding site; inhibition site 909952000850 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 909952000851 homooctamer interface [polypeptide binding]; other site 909952000852 active site 909952000853 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 909952000854 catalytic center binding site [active] 909952000855 ATP binding site [chemical binding]; other site 909952000856 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 909952000857 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 909952000858 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 909952000859 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 909952000860 Lsr2; Region: Lsr2; pfam11774 909952000861 Clp protease ATP binding subunit; Region: clpC; CHL00095 909952000862 Clp amino terminal domain; Region: Clp_N; pfam02861 909952000863 Clp amino terminal domain; Region: Clp_N; pfam02861 909952000864 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 909952000865 Walker A motif; other site 909952000866 ATP binding site [chemical binding]; other site 909952000867 Walker B motif; other site 909952000868 arginine finger; other site 909952000869 UvrB/uvrC motif; Region: UVR; pfam02151 909952000870 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 909952000871 Walker A motif; other site 909952000872 ATP binding site [chemical binding]; other site 909952000873 Walker B motif; other site 909952000874 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 909952000875 Protein of unknown function (DUF2891); Region: DUF2891; pfam11199 909952000876 Predicted membrane protein [Function unknown]; Region: COG3817 909952000877 Protein of unknown function (DUF979); Region: DUF979; pfam06166 909952000878 Protein of unknown function (DUF969); Region: DUF969; pfam06149 909952000879 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 909952000880 putative active site [active] 909952000881 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 909952000882 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 909952000883 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 909952000884 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909952000885 putative substrate translocation pore; other site 909952000886 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909952000887 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 909952000888 TIGR01777 family protein; Region: yfcH 909952000889 putative NAD(P) binding site [chemical binding]; other site 909952000890 putative active site [active] 909952000891 Rhomboid family; Region: Rhomboid; pfam01694 909952000892 hypothetical protein; Provisional; Region: PRK06547 909952000893 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 909952000894 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 909952000895 active site 909952000896 phosphorylation site [posttranslational modification] 909952000897 intermolecular recognition site; other site 909952000898 dimerization interface [polypeptide binding]; other site 909952000899 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 909952000900 DNA binding residues [nucleotide binding] 909952000901 dimerization interface [polypeptide binding]; other site 909952000902 Histidine kinase; Region: HisKA_3; pfam07730 909952000903 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 909952000904 ATP binding site [chemical binding]; other site 909952000905 Mg2+ binding site [ion binding]; other site 909952000906 G-X-G motif; other site 909952000907 CAT RNA binding domain; Region: CAT_RBD; smart01061 909952000908 transcriptional antiterminator BglG; Provisional; Region: PRK09772 909952000909 PRD domain; Region: PRD; pfam00874 909952000910 PRD domain; Region: PRD; pfam00874 909952000911 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 909952000912 HPr interaction site; other site 909952000913 glycerol kinase (GK) interaction site [polypeptide binding]; other site 909952000914 active site 909952000915 phosphorylation site [posttranslational modification] 909952000916 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 909952000917 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 909952000918 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 909952000919 active site turn [active] 909952000920 phosphorylation site [posttranslational modification] 909952000921 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 909952000922 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 909952000923 endonuclease III; Region: ENDO3c; smart00478 909952000924 minor groove reading motif; other site 909952000925 helix-hairpin-helix signature motif; other site 909952000926 active site 909952000927 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 909952000928 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 909952000929 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 909952000930 inhibitor-cofactor binding pocket; inhibition site 909952000931 pyridoxal 5'-phosphate binding site [chemical binding]; other site 909952000932 catalytic residue [active] 909952000933 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 909952000934 dimer interface [polypeptide binding]; other site 909952000935 active site 909952000936 Schiff base residues; other site 909952000937 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 909952000938 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 909952000939 active site 909952000940 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 909952000941 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 909952000942 domain interfaces; other site 909952000943 active site 909952000944 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 909952000945 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 909952000946 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 909952000947 substrate binding site [chemical binding]; other site 909952000948 active site 909952000949 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 909952000950 Glutamyl-tRNAGlu reductase, N-terminal domain; Region: GlutR_N; pfam05201 909952000951 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 909952000952 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 909952000953 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 909952000954 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 909952000955 DNA repair protein RadA; Provisional; Region: PRK11823 909952000956 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 909952000957 Walker A motif; other site 909952000958 ATP binding site [chemical binding]; other site 909952000959 Walker B motif; other site 909952000960 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 909952000961 malate dehydrogenase; Provisional; Region: PRK13529 909952000962 Malic enzyme, N-terminal domain; Region: malic; pfam00390 909952000963 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 909952000964 NAD(P) binding site [chemical binding]; other site 909952000965 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 909952000966 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 909952000967 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 909952000968 AP (apurinic/apyrimidinic) site pocket; other site 909952000969 DNA interaction; other site 909952000970 Metal-binding active site; metal-binding site 909952000971 Proline dehydrogenase; Region: Pro_dh; cl03282 909952000972 CAAX protease self-immunity; Region: Abi; pfam02517 909952000973 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 909952000974 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 909952000975 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 909952000976 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 909952000977 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 909952000978 active site 909952000979 homodimer interface [polypeptide binding]; other site 909952000980 SAM binding site [chemical binding]; other site 909952000981 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 909952000982 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 909952000983 active site 909952000984 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 909952000985 catalytic core [active] 909952000986 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 909952000987 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 909952000988 catalytic residues [active] 909952000989 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 909952000990 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 909952000991 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 909952000992 ResB-like family; Region: ResB; pfam05140 909952000993 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 909952000994 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 909952000995 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 909952000996 Sporulation and spore germination; Region: Germane; pfam10646 909952000997 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 909952000998 classical (c) SDRs; Region: SDR_c; cd05233 909952000999 NAD(P) binding site [chemical binding]; other site 909952001000 active site 909952001001 mycothione reductase; Reviewed; Region: PRK07846 909952001002 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 909952001003 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 909952001004 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 909952001005 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 909952001006 intersubunit interface [polypeptide binding]; other site 909952001007 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 909952001008 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 909952001009 Walker A/P-loop; other site 909952001010 ATP binding site [chemical binding]; other site 909952001011 Q-loop/lid; other site 909952001012 ABC transporter signature motif; other site 909952001013 Walker B; other site 909952001014 D-loop; other site 909952001015 H-loop/switch region; other site 909952001016 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 909952001017 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 909952001018 ABC-ATPase subunit interface; other site 909952001019 dimer interface [polypeptide binding]; other site 909952001020 putative PBP binding regions; other site 909952001021 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 909952001022 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 909952001023 FAD binding pocket [chemical binding]; other site 909952001024 FAD binding motif [chemical binding]; other site 909952001025 phosphate binding motif [ion binding]; other site 909952001026 NAD binding pocket [chemical binding]; other site 909952001027 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 909952001028 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 909952001029 Walker A/P-loop; other site 909952001030 ATP binding site [chemical binding]; other site 909952001031 Q-loop/lid; other site 909952001032 ABC transporter signature motif; other site 909952001033 Walker B; other site 909952001034 D-loop; other site 909952001035 H-loop/switch region; other site 909952001036 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 909952001037 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 909952001038 dimer interface [polypeptide binding]; other site 909952001039 conserved gate region; other site 909952001040 putative PBP binding loops; other site 909952001041 ABC-ATPase subunit interface; other site 909952001042 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 909952001043 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 909952001044 dimer interface [polypeptide binding]; other site 909952001045 conserved gate region; other site 909952001046 putative PBP binding loops; other site 909952001047 ABC-ATPase subunit interface; other site 909952001048 PBP superfamily domain; Region: PBP_like_2; cl17296 909952001049 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 909952001050 active site 909952001051 Ap6A binding site [chemical binding]; other site 909952001052 nudix motif; other site 909952001053 metal binding site [ion binding]; metal-binding site 909952001054 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 909952001055 catalytic core [active] 909952001056 polyphosphate kinase; Provisional; Region: PRK05443 909952001057 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 909952001058 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 909952001059 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 909952001060 putative domain interface [polypeptide binding]; other site 909952001061 putative active site [active] 909952001062 catalytic site [active] 909952001063 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 909952001064 putative domain interface [polypeptide binding]; other site 909952001065 putative active site [active] 909952001066 catalytic site [active] 909952001067 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 909952001068 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 909952001069 DNA binding site [nucleotide binding] 909952001070 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 909952001071 putative active site [active] 909952001072 dimerization interface [polypeptide binding]; other site 909952001073 putative tRNAtyr binding site [nucleotide binding]; other site 909952001074 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 909952001075 heme-binding site [chemical binding]; other site 909952001076 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 909952001077 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 909952001078 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 909952001079 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 909952001080 Bacterial sugar transferase; Region: Bac_transf; pfam02397 909952001081 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 909952001082 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 909952001083 NAD(P) binding site [chemical binding]; other site 909952001084 active site 909952001085 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 909952001086 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 909952001087 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 909952001088 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 909952001089 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 909952001090 dimerization domain swap beta strand [polypeptide binding]; other site 909952001091 regulatory protein interface [polypeptide binding]; other site 909952001092 active site 909952001093 regulatory phosphorylation site [posttranslational modification]; other site 909952001094 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 909952001095 substrate binding site; other site 909952001096 dimer interface; other site 909952001097 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 909952001098 homotrimer interaction site [polypeptide binding]; other site 909952001099 zinc binding site [ion binding]; other site 909952001100 CDP-binding sites; other site 909952001101 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829 909952001102 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 909952001103 active site 909952001104 P-loop; other site 909952001105 phosphorylation site [posttranslational modification] 909952001106 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 909952001107 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 909952001108 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 909952001109 active site 909952001110 phosphorylation site [posttranslational modification] 909952001111 intermolecular recognition site; other site 909952001112 dimerization interface [polypeptide binding]; other site 909952001113 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 909952001114 DNA binding site [nucleotide binding] 909952001115 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 909952001116 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 909952001117 dimer interface [polypeptide binding]; other site 909952001118 phosphorylation site [posttranslational modification] 909952001119 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 909952001120 ATP binding site [chemical binding]; other site 909952001121 Mg2+ binding site [ion binding]; other site 909952001122 G-X-G motif; other site 909952001123 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 909952001124 PhoU domain; Region: PhoU; pfam01895 909952001125 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 909952001126 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 909952001127 NodB motif; other site 909952001128 active site 909952001129 catalytic site [active] 909952001130 Zn binding site [ion binding]; other site 909952001131 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 909952001132 catalytic core [active] 909952001133 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 909952001134 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 909952001135 active site 909952001136 phosphorylation site [posttranslational modification] 909952001137 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 909952001138 active site 909952001139 P-loop; other site 909952001140 phosphorylation site [posttranslational modification] 909952001141 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 909952001142 active site 909952001143 homodimer interface [polypeptide binding]; other site 909952001144 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 909952001145 serine hydroxymethyltransferase; Provisional; Region: PRK13580 909952001146 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 909952001147 dimer interface [polypeptide binding]; other site 909952001148 active site 909952001149 glycine-pyridoxal phosphate binding site [chemical binding]; other site 909952001150 folate binding site [chemical binding]; other site 909952001151 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 909952001152 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 909952001153 substrate binding site [chemical binding]; other site 909952001154 ATP binding site [chemical binding]; other site 909952001155 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 909952001156 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 909952001157 active site 909952001158 intersubunit interface [polypeptide binding]; other site 909952001159 catalytic residue [active] 909952001160 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 909952001161 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 909952001162 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 909952001163 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 909952001164 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 909952001165 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 909952001166 substrate binding site [chemical binding]; other site 909952001167 catalytic residues [active] 909952001168 Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; cl01752 909952001169 Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; cl01752 909952001170 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 909952001171 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 909952001172 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 909952001173 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 909952001174 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 909952001175 active site 909952001176 HIGH motif; other site 909952001177 nucleotide binding site [chemical binding]; other site 909952001178 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 909952001179 KMSKS motif; other site 909952001180 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 909952001181 tRNA binding surface [nucleotide binding]; other site 909952001182 anticodon binding site; other site 909952001183 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 909952001184 Asp23 family; Region: Asp23; pfam03780 909952001185 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 909952001186 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 909952001187 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 909952001188 DNA binding residues [nucleotide binding] 909952001189 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 909952001190 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 909952001191 Walker A/P-loop; other site 909952001192 ATP binding site [chemical binding]; other site 909952001193 Q-loop/lid; other site 909952001194 ABC transporter signature motif; other site 909952001195 Walker B; other site 909952001196 D-loop; other site 909952001197 H-loop/switch region; other site 909952001198 TOBE domain; Region: TOBE_2; pfam08402 909952001199 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 909952001200 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 909952001201 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 909952001202 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 909952001203 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 909952001204 putative DNA binding site [nucleotide binding]; other site 909952001205 putative Zn2+ binding site [ion binding]; other site 909952001206 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 909952001207 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 909952001208 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 909952001209 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 909952001210 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 909952001211 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 909952001212 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 909952001213 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 909952001214 dimer interface [polypeptide binding]; other site 909952001215 conserved gate region; other site 909952001216 putative PBP binding loops; other site 909952001217 ABC-ATPase subunit interface; other site 909952001218 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 909952001219 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 909952001220 dimer interface [polypeptide binding]; other site 909952001221 conserved gate region; other site 909952001222 ABC-ATPase subunit interface; other site 909952001223 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 909952001224 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 909952001225 NAD(P) binding site [chemical binding]; other site 909952001226 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 909952001227 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 909952001228 substrate-cofactor binding pocket; other site 909952001229 pyridoxal 5'-phosphate binding site [chemical binding]; other site 909952001230 catalytic residue [active] 909952001231 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 909952001232 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 909952001233 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 909952001234 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 909952001235 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 909952001236 Walker A/P-loop; other site 909952001237 ATP binding site [chemical binding]; other site 909952001238 Q-loop/lid; other site 909952001239 ABC transporter signature motif; other site 909952001240 Walker B; other site 909952001241 D-loop; other site 909952001242 H-loop/switch region; other site 909952001243 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 909952001244 Protein of unknown function, DUF488; Region: DUF488; cl01246 909952001245 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 909952001246 putative ADP-ribose binding site [chemical binding]; other site 909952001247 putative active site [active] 909952001248 Prostaglandin dehydrogenases; Region: PGDH; cd05288 909952001249 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 909952001250 NAD(P) binding site [chemical binding]; other site 909952001251 substrate binding site [chemical binding]; other site 909952001252 dimer interface [polypeptide binding]; other site 909952001253 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 909952001254 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 909952001255 Walker A/P-loop; other site 909952001256 ATP binding site [chemical binding]; other site 909952001257 Q-loop/lid; other site 909952001258 ABC transporter signature motif; other site 909952001259 Walker B; other site 909952001260 D-loop; other site 909952001261 H-loop/switch region; other site 909952001262 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 909952001263 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 909952001264 Histidine kinase; Region: HisKA_3; pfam07730 909952001265 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 909952001266 ATP binding site [chemical binding]; other site 909952001267 Mg2+ binding site [ion binding]; other site 909952001268 G-X-G motif; other site 909952001269 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 909952001270 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 909952001271 active site 909952001272 phosphorylation site [posttranslational modification] 909952001273 intermolecular recognition site; other site 909952001274 dimerization interface [polypeptide binding]; other site 909952001275 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 909952001276 DNA binding residues [nucleotide binding] 909952001277 dimerization interface [polypeptide binding]; other site 909952001278 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 909952001279 catalytic core [active] 909952001280 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 909952001281 cobyric acid synthase; Provisional; Region: PRK00784 909952001282 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 909952001283 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 909952001284 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 909952001285 catalytic triad [active] 909952001286 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 909952001287 active site 909952001288 SAM binding site [chemical binding]; other site 909952001289 homodimer interface [polypeptide binding]; other site 909952001290 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 909952001291 active site 909952001292 SAM binding site [chemical binding]; other site 909952001293 homodimer interface [polypeptide binding]; other site 909952001294 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 909952001295 putative homodimer interface [polypeptide binding]; other site 909952001296 active site 909952001297 SAM binding site [chemical binding]; other site 909952001298 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 909952001299 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 909952001300 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 909952001301 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 909952001302 active site 909952001303 SAM binding site [chemical binding]; other site 909952001304 homodimer interface [polypeptide binding]; other site 909952001305 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 909952001306 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 909952001307 putative active site [active] 909952001308 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 909952001309 putative active site [active] 909952001310 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 909952001311 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 909952001312 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 909952001313 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 909952001314 putative PBP binding regions; other site 909952001315 ABC-ATPase subunit interface; other site 909952001316 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 909952001317 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 909952001318 Walker A/P-loop; other site 909952001319 ATP binding site [chemical binding]; other site 909952001320 Q-loop/lid; other site 909952001321 ABC transporter signature motif; other site 909952001322 Walker B; other site 909952001323 D-loop; other site 909952001324 H-loop/switch region; other site 909952001325 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 909952001326 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 909952001327 intersubunit interface [polypeptide binding]; other site 909952001328 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 909952001329 AAA domain; Region: AAA_14; pfam13173 909952001330 Nuclease-related domain; Region: NERD; pfam08378 909952001331 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 909952001332 Precorrin-8X methylmutase; Region: CbiC; pfam02570 909952001333 cobalt transport protein CbiM; Validated; Region: PRK08319 909952001334 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 909952001335 cobalt transport protein CbiN; Provisional; Region: PRK02898 909952001336 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 909952001337 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 909952001338 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 909952001339 Walker A/P-loop; other site 909952001340 ATP binding site [chemical binding]; other site 909952001341 Q-loop/lid; other site 909952001342 ABC transporter signature motif; other site 909952001343 Walker B; other site 909952001344 D-loop; other site 909952001345 H-loop/switch region; other site 909952001346 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 909952001347 Methyltransferase domain; Region: Methyltransf_18; pfam12847 909952001348 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 909952001349 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 909952001350 homodimer interface [polypeptide binding]; other site 909952001351 Walker A motif; other site 909952001352 ATP binding site [chemical binding]; other site 909952001353 hydroxycobalamin binding site [chemical binding]; other site 909952001354 Walker B motif; other site 909952001355 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 909952001356 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 909952001357 catalytic triad [active] 909952001358 hypothetical protein; Provisional; Region: PRK07908 909952001359 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 909952001360 pyridoxal 5'-phosphate binding site [chemical binding]; other site 909952001361 homodimer interface [polypeptide binding]; other site 909952001362 catalytic residue [active] 909952001363 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 909952001364 homodimer interface [polypeptide binding]; other site 909952001365 active site 909952001366 SAM binding site [chemical binding]; other site 909952001367 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 909952001368 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 909952001369 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 909952001370 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 909952001371 putative dimer interface [polypeptide binding]; other site 909952001372 active site pocket [active] 909952001373 putative cataytic base [active] 909952001374 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 909952001375 homotrimer interface [polypeptide binding]; other site 909952001376 Walker A motif; other site 909952001377 GTP binding site [chemical binding]; other site 909952001378 Walker B motif; other site 909952001379 cobalamin synthase; Reviewed; Region: cobS; PRK00235 909952001380 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 909952001381 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 909952001382 intersubunit interface [polypeptide binding]; other site 909952001383 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 909952001384 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 909952001385 active site 909952001386 phosphorylation site [posttranslational modification] 909952001387 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 909952001388 active site 909952001389 P-loop; other site 909952001390 phosphorylation site [posttranslational modification] 909952001391 S-Ribosylhomocysteinase (LuxS); Region: LuxS; cl00802 909952001392 DDE superfamily endonuclease; Region: DDE_3; pfam13358 909952001393 S-ribosylhomocysteinase; Provisional; Region: PRK02260 909952001394 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 909952001395 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 909952001396 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 909952001397 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 909952001398 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 909952001399 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 909952001400 ring oligomerisation interface [polypeptide binding]; other site 909952001401 ATP/Mg binding site [chemical binding]; other site 909952001402 stacking interactions; other site 909952001403 hinge regions; other site 909952001404 Transaldolase; Region: Transaldolase; pfam00923 909952001405 catalytic residue [active] 909952001406 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 909952001407 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 909952001408 DNA-binding site [nucleotide binding]; DNA binding site 909952001409 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 909952001410 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 909952001411 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 909952001412 substrate binding site [chemical binding]; other site 909952001413 ATP binding site [chemical binding]; other site 909952001414 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 909952001415 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 909952001416 PYR/PP interface [polypeptide binding]; other site 909952001417 dimer interface [polypeptide binding]; other site 909952001418 TPP binding site [chemical binding]; other site 909952001419 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cd00368 909952001420 molybdopterin cofactor binding site; other site 909952001421 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 909952001422 TPP-binding site; other site 909952001423 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 909952001424 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 909952001425 tetrameric interface [polypeptide binding]; other site 909952001426 NAD binding site [chemical binding]; other site 909952001427 catalytic residues [active] 909952001428 Transcriptional regulators [Transcription]; Region: PurR; COG1609 909952001429 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 909952001430 DNA binding site [nucleotide binding] 909952001431 domain linker motif; other site 909952001432 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 909952001433 dimerization interface [polypeptide binding]; other site 909952001434 ligand binding site [chemical binding]; other site 909952001435 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 909952001436 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 909952001437 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 909952001438 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 909952001439 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 909952001440 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 909952001441 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 909952001442 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 909952001443 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 909952001444 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909952001445 putative substrate translocation pore; other site 909952001446 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909952001447 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 909952001448 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 909952001449 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 909952001450 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 909952001451 DNA interaction; other site 909952001452 Metal-binding active site; metal-binding site 909952001453 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 909952001454 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 909952001455 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 909952001456 CAAX protease self-immunity; Region: Abi; pfam02517 909952001457 CutC family; Region: CutC; cl01218 909952001458 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 909952001459 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 909952001460 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 909952001461 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 909952001462 ATP binding site [chemical binding]; other site 909952001463 putative Mg++ binding site [ion binding]; other site 909952001464 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 909952001465 nucleotide binding region [chemical binding]; other site 909952001466 ATP-binding site [chemical binding]; other site 909952001467 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 909952001468 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 909952001469 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 909952001470 active site 909952001471 trimer interface [polypeptide binding]; other site 909952001472 allosteric site; other site 909952001473 active site lid [active] 909952001474 hexamer (dimer of trimers) interface [polypeptide binding]; other site 909952001475 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 909952001476 DNA-binding site [nucleotide binding]; DNA binding site 909952001477 RNA-binding motif; other site 909952001478 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 909952001479 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 909952001480 phosphoserine aminotransferase; Provisional; Region: PRK03080 909952001481 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 909952001482 catalytic residue [active] 909952001483 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 909952001484 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 909952001485 active site 909952001486 dimer interface [polypeptide binding]; other site 909952001487 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 909952001488 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 909952001489 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 909952001490 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 909952001491 catalytic residues [active] 909952001492 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 909952001493 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909952001494 putative substrate translocation pore; other site 909952001495 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909952001496 Eukaryotic UGPase catalyses the synthesis of UDP-Glucose; Region: UGPase_euk; cd00897 909952001497 active site 909952001498 substrate binding site; other site 909952001499 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 909952001500 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 909952001501 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 909952001502 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 909952001503 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 909952001504 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 909952001505 dimer interface [polypeptide binding]; other site 909952001506 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 909952001507 putative MPT binding site; other site 909952001508 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 909952001509 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 909952001510 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 909952001511 MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor...; Region: MoaC; cl00242 909952001512 trimer interface [polypeptide binding]; other site 909952001513 dimer interface [polypeptide binding]; other site 909952001514 putative active site [active] 909952001515 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 909952001516 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 909952001517 dimer interface [polypeptide binding]; other site 909952001518 putative functional site; other site 909952001519 putative MPT binding site; other site 909952001520 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 909952001521 MoaE homodimer interface [polypeptide binding]; other site 909952001522 MoaD interaction [polypeptide binding]; other site 909952001523 active site residues [active] 909952001524 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 909952001525 MoaE interaction surface [polypeptide binding]; other site 909952001526 MoeB interaction surface [polypeptide binding]; other site 909952001527 thiocarboxylated glycine; other site 909952001528 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 909952001529 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 909952001530 FeS/SAM binding site; other site 909952001531 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 909952001532 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 909952001533 DNA binding residues [nucleotide binding] 909952001534 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 909952001535 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 909952001536 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 909952001537 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 909952001538 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 909952001539 dimer interface [polypeptide binding]; other site 909952001540 conserved gate region; other site 909952001541 putative PBP binding loops; other site 909952001542 ABC-ATPase subunit interface; other site 909952001543 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 909952001544 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 909952001545 Walker A/P-loop; other site 909952001546 ATP binding site [chemical binding]; other site 909952001547 Q-loop/lid; other site 909952001548 ABC transporter signature motif; other site 909952001549 Walker B; other site 909952001550 D-loop; other site 909952001551 H-loop/switch region; other site 909952001552 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 909952001553 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 909952001554 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 909952001555 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 909952001556 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 909952001557 [4Fe-4S] binding site [ion binding]; other site 909952001558 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 909952001559 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 909952001560 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 909952001561 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 909952001562 molybdopterin cofactor binding site; other site 909952001563 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 909952001564 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909952001565 putative substrate translocation pore; other site 909952001566 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 909952001567 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 909952001568 GTP binding site; other site 909952001569 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 909952001570 MPT binding site; other site 909952001571 trimer interface [polypeptide binding]; other site 909952001572 DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519 909952001573 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 909952001574 4Fe-4S binding domain; Region: Fer4; pfam00037 909952001575 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 909952001576 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 909952001577 putative [Fe4-S4] binding site [ion binding]; other site 909952001578 putative molybdopterin cofactor binding site [chemical binding]; other site 909952001579 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 909952001580 putative molybdopterin cofactor binding site; other site 909952001581 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 909952001582 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 909952001583 ATP binding site [chemical binding]; other site 909952001584 substrate interface [chemical binding]; other site 909952001585 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 909952001586 ThiS interaction site; other site 909952001587 putative active site [active] 909952001588 tetramer interface [polypeptide binding]; other site 909952001589 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 909952001590 thiS-thiF/thiG interaction site; other site 909952001591 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 909952001592 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 909952001593 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 909952001594 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 909952001595 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 909952001596 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 909952001597 Predicted methyltransferases [General function prediction only]; Region: COG0313 909952001598 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 909952001599 putative SAM binding site [chemical binding]; other site 909952001600 putative homodimer interface [polypeptide binding]; other site 909952001601 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 909952001602 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 909952001603 active site 909952001604 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 909952001605 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 909952001606 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 909952001607 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 909952001608 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 909952001609 MarR family; Region: MarR_2; cl17246 909952001610 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 909952001611 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 909952001612 DNA-binding interface [nucleotide binding]; DNA binding site 909952001613 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14360 909952001614 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 909952001615 Substrate binding site; other site 909952001616 Mg++ binding site; other site 909952001617 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 909952001618 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 909952001619 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 909952001620 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 909952001621 active site 909952001622 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 909952001623 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 909952001624 5S rRNA interface [nucleotide binding]; other site 909952001625 CTC domain interface [polypeptide binding]; other site 909952001626 L16 interface [polypeptide binding]; other site 909952001627 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 909952001628 putative active site [active] 909952001629 catalytic residue [active] 909952001630 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 909952001631 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 909952001632 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH6; cd08260 909952001633 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 909952001634 putative NAD(P) binding site [chemical binding]; other site 909952001635 catalytic Zn binding site [ion binding]; other site 909952001636 structural Zn binding site [ion binding]; other site 909952001637 Protease prsW family; Region: PrsW-protease; pfam13367 909952001638 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 909952001639 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 909952001640 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 909952001641 ATP binding site [chemical binding]; other site 909952001642 putative Mg++ binding site [ion binding]; other site 909952001643 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 909952001644 nucleotide binding region [chemical binding]; other site 909952001645 ATP-binding site [chemical binding]; other site 909952001646 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 909952001647 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 909952001648 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12333 909952001649 homodimer interface [polypeptide binding]; other site 909952001650 metal binding site [ion binding]; metal-binding site 909952001651 enolase; Provisional; Region: eno; PRK00077 909952001652 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 909952001653 dimer interface [polypeptide binding]; other site 909952001654 metal binding site [ion binding]; metal-binding site 909952001655 substrate binding pocket [chemical binding]; other site 909952001656 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 909952001657 Septum formation initiator; Region: DivIC; pfam04977 909952001658 Protein of unknown function (DUF501); Region: DUF501; pfam04417 909952001659 exopolyphosphatase; Region: exo_poly_only; TIGR03706 909952001660 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 909952001661 Bax inhibitor 1 like; Region: BaxI_1; cl17691 909952001662 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 909952001663 nudix motif; other site 909952001664 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 909952001665 Coenzyme A binding pocket [chemical binding]; other site 909952001666 Predicted membrane protein [Function unknown]; Region: COG2246 909952001667 GtrA-like protein; Region: GtrA; pfam04138 909952001668 Predicted membrane protein [Function unknown]; Region: COG1297 909952001669 putative oligopeptide transporter, OPT family; Region: TIGR00733 909952001670 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 909952001671 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 909952001672 active site 909952001673 catalytic tetrad [active] 909952001674 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 909952001675 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 909952001676 Na2 binding site [ion binding]; other site 909952001677 putative substrate binding site 1 [chemical binding]; other site 909952001678 Na binding site 1 [ion binding]; other site 909952001679 putative substrate binding site 2 [chemical binding]; other site 909952001680 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 909952001681 ligand binding site [chemical binding]; other site 909952001682 active site 909952001683 UGI interface [polypeptide binding]; other site 909952001684 catalytic site [active] 909952001685 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 909952001686 Domain of unknown function DUF20; Region: UPF0118; pfam01594 909952001687 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 909952001688 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 909952001689 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 909952001690 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 909952001691 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 909952001692 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 909952001693 catalytic residues [active] 909952001694 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 909952001695 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 909952001696 catalytic residue [active] 909952001697 putative FPP diphosphate binding site; other site 909952001698 putative FPP binding hydrophobic cleft; other site 909952001699 dimer interface [polypeptide binding]; other site 909952001700 putative IPP diphosphate binding site; other site 909952001701 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 909952001702 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 909952001703 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 909952001704 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 909952001705 putative active site [active] 909952001706 PhoH-like protein; Region: PhoH; pfam02562 909952001707 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 909952001708 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 909952001709 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 909952001710 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 909952001711 generic binding surface II; other site 909952001712 generic binding surface I; other site 909952001713 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 909952001714 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 909952001715 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 909952001716 Phosphoesterase family; Region: Phosphoesterase; pfam04185 909952001717 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 909952001718 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 909952001719 RmuC family; Region: RmuC; pfam02646 909952001720 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 909952001721 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 909952001722 active site 909952001723 metal binding site [ion binding]; metal-binding site 909952001724 GTP-binding protein YchF; Reviewed; Region: PRK09601 909952001725 YchF GTPase; Region: YchF; cd01900 909952001726 G1 box; other site 909952001727 GTP/Mg2+ binding site [chemical binding]; other site 909952001728 Switch I region; other site 909952001729 G2 box; other site 909952001730 Switch II region; other site 909952001731 G3 box; other site 909952001732 G4 box; other site 909952001733 G5 box; other site 909952001734 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 909952001735 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909952001736 putative substrate translocation pore; other site 909952001737 Major Facilitator Superfamily; Region: MFS_1; pfam07690 909952001738 Transcriptional regulators [Transcription]; Region: MarR; COG1846 909952001739 MarR family; Region: MarR; pfam01047 909952001740 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 909952001741 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 909952001742 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 909952001743 potential catalytic triad [active] 909952001744 conserved cys residue [active] 909952001745 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 909952001746 Spore germination protein; Region: Spore_permease; cl17796 909952001747 arginine deiminase; Provisional; Region: PRK01388 909952001748 ornithine carbamoyltransferase; Validated; Region: PRK02102 909952001749 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 909952001750 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 909952001751 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 909952001752 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 909952001753 putative substrate binding site [chemical binding]; other site 909952001754 nucleotide binding site [chemical binding]; other site 909952001755 nucleotide binding site [chemical binding]; other site 909952001756 homodimer interface [polypeptide binding]; other site 909952001757 arginine repressor; Provisional; Region: PRK03341 909952001758 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 909952001759 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 909952001760 Peptidyl-tRNA hydrolase, type 2 (PTH2)_like . Peptidyl-tRNA hydrolase activity releases tRNA from the premature translation termination product peptidyl-tRNA. Two structurally different enzymes have been reported to encode such activity, Pth present in...; Region: PTH2_family; cl00869 909952001761 dimer interface [polypeptide binding]; other site 909952001762 putative active site [active] 909952001763 ACT domain; Region: ACT_6; pfam13740 909952001764 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 909952001765 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869 909952001766 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 909952001767 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 909952001768 active site 909952001769 catalytic tetrad [active] 909952001770 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 909952001771 dimer interface [polypeptide binding]; other site 909952001772 catalytic triad [active] 909952001773 peroxidatic and resolving cysteines [active] 909952001774 lysine transporter; Provisional; Region: PRK10836 909952001775 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like; cd11354 909952001776 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 909952001777 active site 909952001778 catalytic site [active] 909952001779 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 909952001780 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 909952001781 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 909952001782 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 909952001783 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 909952001784 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 909952001785 heterodimer interface [polypeptide binding]; other site 909952001786 substrate interaction site [chemical binding]; other site 909952001787 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 909952001788 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 909952001789 active site 909952001790 substrate binding site [chemical binding]; other site 909952001791 coenzyme B12 binding site [chemical binding]; other site 909952001792 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 909952001793 B12 binding site [chemical binding]; other site 909952001794 cobalt ligand [ion binding]; other site 909952001795 membrane ATPase/protein kinase; Provisional; Region: PRK09435 909952001796 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 909952001797 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 909952001798 Walker A; other site 909952001799 G1 box; other site 909952001800 GTP/Mg2+ binding site [chemical binding]; other site 909952001801 Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496 909952001802 active site 909952001803 catalytic triad [active] 909952001804 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 909952001805 RNA binding surface [nucleotide binding]; other site 909952001806 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 909952001807 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 909952001808 Walker A/P-loop; other site 909952001809 ATP binding site [chemical binding]; other site 909952001810 Q-loop/lid; other site 909952001811 ABC transporter signature motif; other site 909952001812 Walker B; other site 909952001813 D-loop; other site 909952001814 H-loop/switch region; other site 909952001815 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 909952001816 dimer interface [polypeptide binding]; other site 909952001817 ABC-ATPase subunit interface; other site 909952001818 putative PBP binding loops; other site 909952001819 Transcriptional regulators [Transcription]; Region: PurR; COG1609 909952001820 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 909952001821 DNA binding site [nucleotide binding] 909952001822 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 909952001823 ligand binding site [chemical binding]; other site 909952001824 dimerization interface (open form) [polypeptide binding]; other site 909952001825 dimerization interface (closed form) [polypeptide binding]; other site 909952001826 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 909952001827 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 909952001828 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 909952001829 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 909952001830 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 909952001831 dimer interface [polypeptide binding]; other site 909952001832 conserved gate region; other site 909952001833 putative PBP binding loops; other site 909952001834 ABC-ATPase subunit interface; other site 909952001835 Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812 909952001836 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 909952001837 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 909952001838 trimer interface [polypeptide binding]; other site 909952001839 hexamer (dimer of trimers) interface [polypeptide binding]; other site 909952001840 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 909952001841 substrate binding site [chemical binding]; other site 909952001842 Mn binding site [ion binding]; other site 909952001843 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 909952001844 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 909952001845 Walker A/P-loop; other site 909952001846 ATP binding site [chemical binding]; other site 909952001847 ABC transporter; Region: ABC_tran; pfam00005 909952001848 Q-loop/lid; other site 909952001849 ABC transporter signature motif; other site 909952001850 Walker B; other site 909952001851 D-loop; other site 909952001852 H-loop/switch region; other site 909952001853 FtsX-like permease family; Region: FtsX; pfam02687 909952001854 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 909952001855 dimer interface [polypeptide binding]; other site 909952001856 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 909952001857 putative PBP binding regions; other site 909952001858 ABC-ATPase subunit interface; other site 909952001859 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 909952001860 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 909952001861 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 909952001862 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 909952001863 intersubunit interface [polypeptide binding]; other site 909952001864 Isochorismatase family; Region: Isochorismatase; pfam00857 909952001865 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 909952001866 catalytic triad [active] 909952001867 conserved cis-peptide bond; other site 909952001868 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 909952001869 Na binding site [ion binding]; other site 909952001870 Proline dehydrogenase; Region: Pro_dh; cl03282 909952001871 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 909952001872 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 909952001873 Glutamate binding site [chemical binding]; other site 909952001874 NAD binding site [chemical binding]; other site 909952001875 catalytic residues [active] 909952001876 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 909952001877 L-iditol 2-dehydrogenase; Region: iditol_2_DH_like; cd08235 909952001878 putative NAD(P) binding site [chemical binding]; other site 909952001879 catalytic Zn binding site [ion binding]; other site 909952001880 dihydroxyacetone kinase; Provisional; Region: PRK14479 909952001881 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 909952001882 DAK2 domain; Region: Dak2; pfam02734 909952001883 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 909952001884 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 909952001885 active site 909952001886 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 909952001887 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 909952001888 Coenzyme A binding pocket [chemical binding]; other site 909952001889 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 909952001890 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 909952001891 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 909952001892 ligand binding site [chemical binding]; other site 909952001893 homodimer interface [polypeptide binding]; other site 909952001894 NAD(P) binding site [chemical binding]; other site 909952001895 trimer interface B [polypeptide binding]; other site 909952001896 trimer interface A [polypeptide binding]; other site 909952001897 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 909952001898 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 909952001899 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 909952001900 Ferredoxin [Energy production and conversion]; Region: COG1146 909952001901 4Fe-4S binding domain; Region: Fer4; pfam00037 909952001902 succinyldiaminopimelate transaminase; Region: DapC_actino; TIGR03539 909952001903 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 909952001904 pyridoxal 5'-phosphate binding site [chemical binding]; other site 909952001905 homodimer interface [polypeptide binding]; other site 909952001906 catalytic residue [active] 909952001907 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 909952001908 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 909952001909 putative trimer interface [polypeptide binding]; other site 909952001910 putative CoA binding site [chemical binding]; other site 909952001911 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 909952001912 Amidinotransferase; Region: Amidinotransf; cl12043 909952001913 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 909952001914 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909952001915 metabolite-proton symporter; Region: 2A0106; TIGR00883 909952001916 putative substrate translocation pore; other site 909952001917 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 909952001918 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 909952001919 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 909952001920 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 909952001921 metal binding site [ion binding]; metal-binding site 909952001922 putative dimer interface [polypeptide binding]; other site 909952001923 DivIVA domain; Region: DivI1A_domain; TIGR03544 909952001924 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 909952001925 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 909952001926 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 909952001927 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 909952001928 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 909952001929 ligand binding site; other site 909952001930 oligomer interface; other site 909952001931 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 909952001932 dimer interface [polypeptide binding]; other site 909952001933 N-terminal domain interface [polypeptide binding]; other site 909952001934 sulfate 1 binding site; other site 909952001935 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 909952001936 S-adenosylmethionine binding site [chemical binding]; other site 909952001937 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 909952001938 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 909952001939 dimer interface [polypeptide binding]; other site 909952001940 active site 909952001941 catalytic residue [active] 909952001942 sec-independent translocase; Provisional; Region: PRK01371 909952001943 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl15381 909952001944 Domain of unknown function DUF59; Region: DUF59; pfam01883 909952001945 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 909952001946 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 909952001947 Walker A motif; other site 909952001948 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 909952001949 PRC-barrel domain; Region: PRC; pfam05239 909952001950 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 909952001951 MgtE intracellular N domain; Region: MgtE_N; smart00924 909952001952 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 909952001953 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 909952001954 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 909952001955 proline aminopeptidase P II; Provisional; Region: PRK10879 909952001956 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 909952001957 active site 909952001958 ribonuclease E; Reviewed; Region: rne; PRK10811 909952001959 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 909952001960 Putative zinc ribbon domain; Region: DUF164; pfam02591 909952001961 YcfA-like protein; Region: YcfA; cl00752 909952001962 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 909952001963 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 909952001964 intersubunit interface [polypeptide binding]; other site 909952001965 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 909952001966 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 909952001967 ABC-ATPase subunit interface; other site 909952001968 dimer interface [polypeptide binding]; other site 909952001969 putative PBP binding regions; other site 909952001970 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 909952001971 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 909952001972 Walker A/P-loop; other site 909952001973 ATP binding site [chemical binding]; other site 909952001974 Q-loop/lid; other site 909952001975 ABC transporter signature motif; other site 909952001976 Walker B; other site 909952001977 D-loop; other site 909952001978 H-loop/switch region; other site 909952001979 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 909952001980 dimer interface [polypeptide binding]; other site 909952001981 [2Fe-2S] cluster binding site [ion binding]; other site 909952001982 Protein of unknown function (DUF466); Region: DUF466; cl01082 909952001983 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 909952001984 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 909952001985 active site 909952001986 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 909952001987 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 909952001988 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 909952001989 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 909952001990 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 909952001991 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 909952001992 metal binding triad; other site 909952001993 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 909952001994 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 909952001995 metal binding triad; other site 909952001996 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 909952001997 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 909952001998 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 909952001999 Uncharacterized conserved protein [Function unknown]; Region: COG0327 909952002000 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 909952002001 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 909952002002 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 909952002003 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 909952002004 putative active site [active] 909952002005 glutamine synthetase, type I; Region: GlnA; TIGR00653 909952002006 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 909952002007 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 909952002008 RDD family; Region: RDD; pfam06271 909952002009 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 909952002010 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 909952002011 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 909952002012 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 909952002013 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 909952002014 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 909952002015 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 909952002016 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 909952002017 DNA-binding site [nucleotide binding]; DNA binding site 909952002018 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 909952002019 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 909952002020 active site turn [active] 909952002021 phosphorylation site [posttranslational modification] 909952002022 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 909952002023 active site turn [active] 909952002024 phosphorylation site [posttranslational modification] 909952002025 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 909952002026 HPr interaction site; other site 909952002027 glycerol kinase (GK) interaction site [polypeptide binding]; other site 909952002028 active site 909952002029 phosphorylation site [posttranslational modification] 909952002030 Protein of unknown function (DUF1440); Region: DUF1440; pfam07274 909952002031 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 909952002032 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 909952002033 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 909952002034 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 909952002035 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 909952002036 Asp-box motif; other site 909952002037 catalytic site [active] 909952002038 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 909952002039 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 909952002040 Asp-box motif; other site 909952002041 catalytic site [active] 909952002042 putative sialic acid transporter; Provisional; Region: PRK03893 909952002043 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909952002044 putative substrate translocation pore; other site 909952002045 CAMP factor (Cfa); Region: CAMP_factor; pfam07373 909952002046 lipoyl synthase; Provisional; Region: PRK05481 909952002047 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 909952002048 FeS/SAM binding site; other site 909952002049 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 909952002050 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 909952002051 metal-binding site [ion binding] 909952002052 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 909952002053 Soluble P-type ATPase [General function prediction only]; Region: COG4087 909952002054 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 909952002055 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 909952002056 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase; Region: SucB_Actino; TIGR02927 909952002057 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 909952002058 E3 interaction surface; other site 909952002059 lipoyl attachment site [posttranslational modification]; other site 909952002060 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 909952002061 E3 interaction surface; other site 909952002062 lipoyl attachment site [posttranslational modification]; other site 909952002063 e3 binding domain; Region: E3_binding; pfam02817 909952002064 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 909952002065 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 909952002066 multifunctional aminopeptidase A; Provisional; Region: PRK00913 909952002067 interface (dimer of trimers) [polypeptide binding]; other site 909952002068 Substrate-binding/catalytic site; other site 909952002069 Zn-binding sites [ion binding]; other site 909952002070 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 909952002071 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 909952002072 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 909952002073 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 909952002074 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 909952002075 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 909952002076 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 909952002077 D-pathway; other site 909952002078 Putative ubiquinol binding site [chemical binding]; other site 909952002079 Low-spin heme (heme b) binding site [chemical binding]; other site 909952002080 Putative water exit pathway; other site 909952002081 Binuclear center (heme o3/CuB) [ion binding]; other site 909952002082 K-pathway; other site 909952002083 Putative proton exit pathway; other site 909952002084 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 909952002085 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 909952002086 Walker A/P-loop; other site 909952002087 ATP binding site [chemical binding]; other site 909952002088 ABC transporter; Region: ABC_tran; pfam00005 909952002089 Q-loop/lid; other site 909952002090 ABC transporter signature motif; other site 909952002091 Walker B; other site 909952002092 D-loop; other site 909952002093 H-loop/switch region; other site 909952002094 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 909952002095 NADH(P)-binding; Region: NAD_binding_10; pfam13460 909952002096 NAD(P) binding site [chemical binding]; other site 909952002097 active site 909952002098 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 909952002099 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 909952002100 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 909952002101 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 909952002102 phosphate binding site [ion binding]; other site 909952002103 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 909952002104 DNA binding site [nucleotide binding] 909952002105 active site 909952002106 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 909952002107 heme bL binding site [chemical binding]; other site 909952002108 interchain domain interface [polypeptide binding]; other site 909952002109 intrachain domain interface; other site 909952002110 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 909952002111 heme bH binding site [chemical binding]; other site 909952002112 Qo binding site; other site 909952002113 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 909952002114 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 909952002115 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 909952002116 iron-sulfur cluster [ion binding]; other site 909952002117 [2Fe-2S] cluster binding site [ion binding]; other site 909952002118 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 909952002119 Cytochrome c; Region: Cytochrom_C; pfam00034 909952002120 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 909952002121 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 909952002122 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 909952002123 Subunit I/III interface [polypeptide binding]; other site 909952002124 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 909952002125 active site 909952002126 phosphorylation site [posttranslational modification] 909952002127 intermolecular recognition site; other site 909952002128 dimerization interface [polypeptide binding]; other site 909952002129 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 909952002130 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304 909952002131 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 909952002132 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 909952002133 active site 909952002134 Rhomboid family; Region: Rhomboid; cl11446 909952002135 hypothetical protein; Validated; Region: PRK07883 909952002136 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 909952002137 active site 909952002138 catalytic site [active] 909952002139 substrate binding site [chemical binding]; other site 909952002140 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 909952002141 GIY-YIG motif/motif A; other site 909952002142 active site 909952002143 catalytic site [active] 909952002144 putative DNA binding site [nucleotide binding]; other site 909952002145 metal binding site [ion binding]; metal-binding site 909952002146 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 909952002147 NlpC/P60 family; Region: NLPC_P60; pfam00877 909952002148 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 909952002149 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 909952002150 nucleotide binding site [chemical binding]; other site 909952002151 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 909952002152 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 909952002153 putative acyl-acceptor binding pocket; other site 909952002154 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 909952002155 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 909952002156 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 909952002157 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 909952002158 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 909952002159 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 909952002160 EamA-like transporter family; Region: EamA; pfam00892 909952002161 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 909952002162 Catalytic domain of Protein Kinases; Region: PKc; cd00180 909952002163 active site 909952002164 ATP binding site [chemical binding]; other site 909952002165 substrate binding site [chemical binding]; other site 909952002166 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 909952002167 substrate binding site [chemical binding]; other site 909952002168 activation loop (A-loop); other site 909952002169 activation loop (A-loop); other site 909952002170 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607 909952002171 active site 909952002172 barstar interaction site; other site 909952002173 Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141 909952002174 putative RNAase interaction site [polypeptide binding]; other site 909952002175 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 909952002176 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 909952002177 substrate binding pocket [chemical binding]; other site 909952002178 chain length determination region; other site 909952002179 substrate-Mg2+ binding site; other site 909952002180 catalytic residues [active] 909952002181 aspartate-rich region 1; other site 909952002182 active site lid residues [active] 909952002183 aspartate-rich region 2; other site 909952002184 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246 909952002185 Part of AAA domain; Region: AAA_19; pfam13245 909952002186 Family description; Region: UvrD_C_2; pfam13538 909952002187 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 909952002188 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 909952002189 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 909952002190 putative dimer interface [polypeptide binding]; other site 909952002191 fructuronate transporter; Provisional; Region: PRK10034; cl15264 909952002192 Transcriptional regulators [Transcription]; Region: GntR; COG1802 909952002193 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 909952002194 DNA-binding site [nucleotide binding]; DNA binding site 909952002195 FCD domain; Region: FCD; pfam07729 909952002196 glycine dehydrogenase; Provisional; Region: PRK05367 909952002197 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 909952002198 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 909952002199 catalytic residue [active] 909952002200 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 909952002201 tetramer interface [polypeptide binding]; other site 909952002202 pyridoxal 5'-phosphate binding site [chemical binding]; other site 909952002203 catalytic residue [active] 909952002204 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 909952002205 lipoyl attachment site [posttranslational modification]; other site 909952002206 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 909952002207 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 909952002208 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 909952002209 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 909952002210 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 909952002211 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 909952002212 Protein of unknown function DUF58; Region: DUF58; pfam01882 909952002213 MoxR-like ATPases [General function prediction only]; Region: COG0714 909952002214 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 909952002215 ATP binding site [chemical binding]; other site 909952002216 Walker A motif; other site 909952002217 Walker B motif; other site 909952002218 arginine finger; other site 909952002219 cell division protein MraZ; Reviewed; Region: PRK00326 909952002220 MraZ protein; Region: MraZ; pfam02381 909952002221 MraZ protein; Region: MraZ; pfam02381 909952002222 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 909952002223 MraW methylase family; Region: Methyltransf_5; cl17771 909952002224 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 909952002225 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 909952002226 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 909952002227 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 909952002228 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 909952002229 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 909952002230 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 909952002231 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 909952002232 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 909952002233 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 909952002234 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 909952002235 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 909952002236 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 909952002237 Mg++ binding site [ion binding]; other site 909952002238 putative catalytic motif [active] 909952002239 putative substrate binding site [chemical binding]; other site 909952002240 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438 909952002241 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 909952002242 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 909952002243 cell division protein FtsW; Region: ftsW; TIGR02614 909952002244 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 909952002245 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 909952002246 active site 909952002247 homodimer interface [polypeptide binding]; other site 909952002248 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 909952002249 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 909952002250 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 909952002251 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 909952002252 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 909952002253 Cell division protein FtsQ; Region: FtsQ; pfam03799 909952002254 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 909952002255 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 909952002256 nucleotide binding site [chemical binding]; other site 909952002257 SulA interaction site; other site 909952002258 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 909952002259 Protein of unknown function (DUF552); Region: DUF552; pfam04472 909952002260 DivIVA protein; Region: DivIVA; pfam05103 909952002261 DivIVA domain; Region: DivI1A_domain; TIGR03544 909952002262 V-type ATP synthase subunit E; Provisional; Region: PRK02292 909952002263 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 909952002264 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 909952002265 lipoprotein signal peptidase; Provisional; Region: PRK14787 909952002266 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 909952002267 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 909952002268 RNA binding surface [nucleotide binding]; other site 909952002269 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 909952002270 active site 909952002271 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 909952002272 pyruvate kinase; Provisional; Region: PRK06247 909952002273 domain interfaces; other site 909952002274 active site 909952002275 CrcB-like protein; Region: CRCB; pfam02537 909952002276 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 909952002277 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 909952002278 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 909952002279 active site 909952002280 phosphorylation site [posttranslational modification] 909952002281 intermolecular recognition site; other site 909952002282 dimerization interface [polypeptide binding]; other site 909952002283 ANTAR domain; Region: ANTAR; pfam03861 909952002284 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 909952002285 CoenzymeA binding site [chemical binding]; other site 909952002286 subunit interaction site [polypeptide binding]; other site 909952002287 PHB binding site; other site 909952002288 DNA polymerase I; Provisional; Region: PRK05755 909952002289 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 909952002290 active site 909952002291 metal binding site 1 [ion binding]; metal-binding site 909952002292 putative 5' ssDNA interaction site; other site 909952002293 metal binding site 3; metal-binding site 909952002294 metal binding site 2 [ion binding]; metal-binding site 909952002295 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 909952002296 putative DNA binding site [nucleotide binding]; other site 909952002297 putative metal binding site [ion binding]; other site 909952002298 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 909952002299 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 909952002300 active site 909952002301 DNA binding site [nucleotide binding] 909952002302 catalytic site [active] 909952002303 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 909952002304 active site 909952002305 putative catalytic site [active] 909952002306 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 909952002307 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 909952002308 RNA binding site [nucleotide binding]; other site 909952002309 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 909952002310 RNA binding site [nucleotide binding]; other site 909952002311 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 909952002312 RNA binding site [nucleotide binding]; other site 909952002313 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 909952002314 RNA binding site [nucleotide binding]; other site 909952002315 domain interface; other site 909952002316 Htaa; Region: HtaA; pfam04213 909952002317 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 909952002318 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 909952002319 intersubunit interface [polypeptide binding]; other site 909952002320 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 909952002321 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 909952002322 ABC-ATPase subunit interface; other site 909952002323 dimer interface [polypeptide binding]; other site 909952002324 putative PBP binding regions; other site 909952002325 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 909952002326 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 909952002327 Walker A/P-loop; other site 909952002328 ATP binding site [chemical binding]; other site 909952002329 Q-loop/lid; other site 909952002330 ABC transporter signature motif; other site 909952002331 Walker B; other site 909952002332 D-loop; other site 909952002333 H-loop/switch region; other site 909952002334 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 909952002335 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 909952002336 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 909952002337 Walker A/P-loop; other site 909952002338 ATP binding site [chemical binding]; other site 909952002339 Q-loop/lid; other site 909952002340 ABC transporter signature motif; other site 909952002341 Walker B; other site 909952002342 D-loop; other site 909952002343 H-loop/switch region; other site 909952002344 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 909952002345 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 909952002346 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 909952002347 Walker A/P-loop; other site 909952002348 ATP binding site [chemical binding]; other site 909952002349 Q-loop/lid; other site 909952002350 ABC transporter signature motif; other site 909952002351 Walker B; other site 909952002352 D-loop; other site 909952002353 H-loop/switch region; other site 909952002354 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 909952002355 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 909952002356 CoA-binding site [chemical binding]; other site 909952002357 ATP-binding [chemical binding]; other site 909952002358 Htaa; Region: HtaA; pfam04213 909952002359 Htaa; Region: HtaA; pfam04213 909952002360 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 909952002361 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 909952002362 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 909952002363 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 909952002364 metal ion-dependent adhesion site (MIDAS); other site 909952002365 Domain of unknown function (DUF3479); Region: DUF3479; pfam11965 909952002366 CobN/Magnesium Chelatase; Region: CobN-Mg_chel; pfam02514 909952002367 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 909952002368 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 909952002369 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 909952002370 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 909952002371 Walker A/P-loop; other site 909952002372 ATP binding site [chemical binding]; other site 909952002373 Q-loop/lid; other site 909952002374 ABC transporter signature motif; other site 909952002375 Walker B; other site 909952002376 D-loop; other site 909952002377 H-loop/switch region; other site 909952002378 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 909952002379 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 909952002380 ABC-ATPase subunit interface; other site 909952002381 dimer interface [polypeptide binding]; other site 909952002382 putative PBP binding regions; other site 909952002383 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 909952002384 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 909952002385 intersubunit interface [polypeptide binding]; other site 909952002386 Bacteriocin (Lactococcin_972); Region: Lactococcin_972; cl09891 909952002387 excinuclease ABC subunit B; Provisional; Region: PRK05298 909952002388 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 909952002389 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 909952002390 nucleotide binding region [chemical binding]; other site 909952002391 ATP-binding site [chemical binding]; other site 909952002392 Ultra-violet resistance protein B; Region: UvrB; pfam12344 909952002393 UvrB/uvrC motif; Region: UVR; pfam02151 909952002394 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 909952002395 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 909952002396 mycothiol-dependent maleylpyruvate isomerase; Reviewed; Region: PRK09583 909952002397 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 909952002398 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 909952002399 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 909952002400 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 909952002401 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 909952002402 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 909952002403 iron-sulfur cluster [ion binding]; other site 909952002404 [2Fe-2S] cluster binding site [ion binding]; other site 909952002405 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 909952002406 catalytic core [active] 909952002407 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 909952002408 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 909952002409 GIY-YIG motif/motif A; other site 909952002410 active site 909952002411 catalytic site [active] 909952002412 putative DNA binding site [nucleotide binding]; other site 909952002413 metal binding site [ion binding]; metal-binding site 909952002414 UvrB/uvrC motif; Region: UVR; pfam02151 909952002415 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 909952002416 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 909952002417 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 909952002418 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 909952002419 phosphate binding site [ion binding]; other site 909952002420 putative substrate binding pocket [chemical binding]; other site 909952002421 dimer interface [polypeptide binding]; other site 909952002422 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 909952002423 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 909952002424 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 909952002425 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 909952002426 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 909952002427 Phosphoglycerate kinase; Region: PGK; pfam00162 909952002428 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 909952002429 substrate binding site [chemical binding]; other site 909952002430 hinge regions; other site 909952002431 ADP binding site [chemical binding]; other site 909952002432 catalytic site [active] 909952002433 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 909952002434 triosephosphate isomerase; Provisional; Region: PRK14567 909952002435 substrate binding site [chemical binding]; other site 909952002436 dimer interface [polypeptide binding]; other site 909952002437 catalytic triad [active] 909952002438 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 909952002439 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 909952002440 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 909952002441 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 909952002442 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 909952002443 active site 909952002444 multimer interface [polypeptide binding]; other site 909952002445 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 909952002446 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 909952002447 B12 binding site [chemical binding]; other site 909952002448 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 909952002449 FeS/SAM binding site; other site 909952002450 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 909952002451 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105 909952002452 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 909952002453 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 909952002454 homodimer interface [polypeptide binding]; other site 909952002455 oligonucleotide binding site [chemical binding]; other site 909952002456 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 909952002457 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 909952002458 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 909952002459 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909952002460 Major Facilitator Superfamily; Region: MFS_1; pfam07690 909952002461 putative substrate translocation pore; other site 909952002462 GTP1/OBG; Region: GTP1_OBG; pfam01018 909952002463 GTP1/OBG; Region: GTP1_OBG; pfam01018 909952002464 GTPase CgtA; Reviewed; Region: obgE; PRK12296 909952002465 Obg GTPase; Region: Obg; cd01898 909952002466 G1 box; other site 909952002467 GTP/Mg2+ binding site [chemical binding]; other site 909952002468 Switch I region; other site 909952002469 G2 box; other site 909952002470 G3 box; other site 909952002471 Switch II region; other site 909952002472 G4 box; other site 909952002473 G5 box; other site 909952002474 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 909952002475 gamma-glutamyl kinase; Provisional; Region: PRK05429 909952002476 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 909952002477 nucleotide binding site [chemical binding]; other site 909952002478 homotetrameric interface [polypeptide binding]; other site 909952002479 putative phosphate binding site [ion binding]; other site 909952002480 putative allosteric binding site; other site 909952002481 PUA domain; Region: PUA; pfam01472 909952002482 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 909952002483 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 909952002484 putative catalytic cysteine [active] 909952002485 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 909952002486 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 909952002487 active site 909952002488 (T/H)XGH motif; other site 909952002489 Oligomerisation domain; Region: Oligomerisation; pfam02410 909952002490 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 909952002491 catalytic core [active] 909952002492 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 909952002493 substrate binding site [chemical binding]; other site 909952002494 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 909952002495 Walker B; other site 909952002496 D-loop; other site 909952002497 H-loop/switch region; other site 909952002498 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 909952002499 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 909952002500 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 909952002501 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 909952002502 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 909952002503 Transposase, Mutator family; Region: Transposase_mut; pfam00872 909952002504 Transposase, Mutator family; Region: Transposase_mut; pfam00872 909952002505 FtsX-like permease family; Region: FtsX; pfam02687 909952002506 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 909952002507 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 909952002508 Walker A/P-loop; other site 909952002509 ATP binding site [chemical binding]; other site 909952002510 Q-loop/lid; other site 909952002511 ABC transporter signature motif; other site 909952002512 Walker B; other site 909952002513 D-loop; other site 909952002514 H-loop/switch region; other site 909952002515 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 909952002516 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 909952002517 ATP binding site [chemical binding]; other site 909952002518 Mg2+ binding site [ion binding]; other site 909952002519 G-X-G motif; other site 909952002520 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 909952002521 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 909952002522 active site 909952002523 phosphorylation site [posttranslational modification] 909952002524 intermolecular recognition site; other site 909952002525 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 909952002526 DNA binding residues [nucleotide binding] 909952002527 Uncharacterized conserved protein [Function unknown]; Region: COG5441; cl02262 909952002528 Uncharacterized conserved protein [Function unknown]; Region: COG5441; cl02262 909952002529 aspartate aminotransferase; Provisional; Region: PRK05764 909952002530 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 909952002531 Transposase; Region: DDE_Tnp_ISL3; pfam01610 909952002532 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 909952002533 Walker A/P-loop; other site 909952002534 ATP binding site [chemical binding]; other site 909952002535 Q-loop/lid; other site 909952002536 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 909952002537 ABC transporter signature motif; other site 909952002538 Walker B; other site 909952002539 D-loop; other site 909952002540 H-loop/switch region; other site 909952002541 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 909952002542 Walker A/P-loop; other site 909952002543 ATP binding site [chemical binding]; other site 909952002544 Q-loop/lid; other site 909952002545 ABC transporter signature motif; other site 909952002546 Walker B; other site 909952002547 D-loop; other site 909952002548 H-loop/switch region; other site 909952002549 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 909952002550 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 909952002551 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 909952002552 active site 909952002553 substrate binding pocket [chemical binding]; other site 909952002554 homodimer interaction site [polypeptide binding]; other site 909952002555 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 909952002556 active site 909952002557 dimer interface [polypeptide binding]; other site 909952002558 magnesium binding site [ion binding]; other site 909952002559 L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209 909952002560 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 909952002561 AP (apurinic/apyrimidinic) site pocket; other site 909952002562 DNA interaction; other site 909952002563 Metal-binding active site; metal-binding site 909952002564 L-ribulose-5-phosphate 4-epimerase; Validated; Region: PRK06557 909952002565 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 909952002566 intersubunit interface [polypeptide binding]; other site 909952002567 active site 909952002568 Zn2+ binding site [ion binding]; other site 909952002569 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 909952002570 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 909952002571 substrate binding site [chemical binding]; other site 909952002572 ATP binding site [chemical binding]; other site 909952002573 benzoate transport; Region: 2A0115; TIGR00895 909952002574 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909952002575 putative substrate translocation pore; other site 909952002576 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 909952002577 substrate binding site [chemical binding]; other site 909952002578 multimerization interface [polypeptide binding]; other site 909952002579 ATP binding site [chemical binding]; other site 909952002580 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 909952002581 active site 909952002582 thiamine phosphate binding site [chemical binding]; other site 909952002583 pyrophosphate binding site [ion binding]; other site 909952002584 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 909952002585 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 909952002586 dimer interface [polypeptide binding]; other site 909952002587 NAD binding site [chemical binding]; other site 909952002588 substrate binding site [chemical binding]; other site 909952002589 tetramer (dimer of dimers) interface [polypeptide binding]; other site 909952002590 malate dehydrogenase; Provisional; Region: PRK13529 909952002591 Malic enzyme, N-terminal domain; Region: malic; pfam00390 909952002592 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 909952002593 NAD(P) binding site [chemical binding]; other site 909952002594 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 909952002595 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 909952002596 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 909952002597 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 909952002598 HIGH motif; other site 909952002599 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 909952002600 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 909952002601 active site 909952002602 KMSKS motif; other site 909952002603 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 909952002604 tRNA binding surface [nucleotide binding]; other site 909952002605 SLBB domain; Region: SLBB; pfam10531 909952002606 comEA protein; Region: comE; TIGR01259 909952002607 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 909952002608 Competence protein; Region: Competence; pfam03772 909952002609 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 909952002610 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 909952002611 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 909952002612 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 909952002613 ATP binding site [chemical binding]; other site 909952002614 putative Mg++ binding site [ion binding]; other site 909952002615 hypothetical protein; Reviewed; Region: PRK07914 909952002616 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 909952002617 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 909952002618 Alpha amylase catalytic domain found in Amylosucrase; Region: AmyAc_Amylosucrase; cd11324 909952002619 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 909952002620 active site 909952002621 catalytic site [active] 909952002622 GTP-binding protein LepA; Provisional; Region: PRK05433 909952002623 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 909952002624 G1 box; other site 909952002625 putative GEF interaction site [polypeptide binding]; other site 909952002626 GTP/Mg2+ binding site [chemical binding]; other site 909952002627 Switch I region; other site 909952002628 G2 box; other site 909952002629 G3 box; other site 909952002630 Switch II region; other site 909952002631 G4 box; other site 909952002632 G5 box; other site 909952002633 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 909952002634 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 909952002635 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 909952002636 O-succinylbenzoate synthase; Provisional; Region: PRK02901 909952002637 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 909952002638 active site 909952002639 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase; Region: menD; TIGR00173 909952002640 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 909952002641 dimer interface [polypeptide binding]; other site 909952002642 tetramer interface [polypeptide binding]; other site 909952002643 PYR/PP interface [polypeptide binding]; other site 909952002644 TPP binding site [chemical binding]; other site 909952002645 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 909952002646 TPP-binding site [chemical binding]; other site 909952002647 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 909952002648 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 909952002649 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 909952002650 acyl-activating enzyme (AAE) consensus motif; other site 909952002651 AMP binding site [chemical binding]; other site 909952002652 active site 909952002653 CoA binding site [chemical binding]; other site 909952002654 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 909952002655 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 909952002656 substrate binding site [chemical binding]; other site 909952002657 oxyanion hole (OAH) forming residues; other site 909952002658 trimer interface [polypeptide binding]; other site 909952002659 Rhomboid family; Region: Rhomboid; pfam01694 909952002660 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 909952002661 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 909952002662 acyl-activating enzyme (AAE) consensus motif; other site 909952002663 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 909952002664 AMP binding site [chemical binding]; other site 909952002665 active site 909952002666 CoA binding site [chemical binding]; other site 909952002667 coproporphyrinogen III oxidase; Validated; Region: PRK05628 909952002668 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 909952002669 FeS/SAM binding site; other site 909952002670 HemN C-terminal domain; Region: HemN_C; pfam06969 909952002671 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 909952002672 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 909952002673 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 909952002674 active site 909952002675 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 909952002676 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 909952002677 chaperone protein DnaJ; Provisional; Region: PRK14278 909952002678 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 909952002679 HSP70 interaction site [polypeptide binding]; other site 909952002680 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 909952002681 Zn binding sites [ion binding]; other site 909952002682 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 909952002683 dimer interface [polypeptide binding]; other site 909952002684 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 909952002685 RNA methyltransferase, RsmE family; Region: TIGR00046 909952002686 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 909952002687 L-iditol 2-dehydrogenase; Region: iditol_2_DH_like; cd08235 909952002688 putative NAD(P) binding site [chemical binding]; other site 909952002689 catalytic Zn binding site [ion binding]; other site 909952002690 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 909952002691 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 909952002692 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 909952002693 active site 909952002694 P-loop; other site 909952002695 phosphorylation site [posttranslational modification] 909952002696 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 909952002697 active site 909952002698 phosphorylation site [posttranslational modification] 909952002699 Predicted membrane protein [Function unknown]; Region: COG2259 909952002700 DEAD-like helicases superfamily; Region: DEXDc; smart00487 909952002701 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 909952002702 ATP binding site [chemical binding]; other site 909952002703 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 909952002704 putative Mg++ binding site [ion binding]; other site 909952002705 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 909952002706 nucleotide binding region [chemical binding]; other site 909952002707 ATP-binding site [chemical binding]; other site 909952002708 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 909952002709 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 909952002710 EamA-like transporter family; Region: EamA; pfam00892 909952002711 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 909952002712 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 909952002713 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 909952002714 Histidine kinase; Region: HisKA_3; pfam07730 909952002715 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 909952002716 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 909952002717 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 909952002718 Walker A/P-loop; other site 909952002719 ATP binding site [chemical binding]; other site 909952002720 Q-loop/lid; other site 909952002721 ABC transporter signature motif; other site 909952002722 Walker B; other site 909952002723 D-loop; other site 909952002724 H-loop/switch region; other site 909952002725 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 909952002726 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 909952002727 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 909952002728 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 909952002729 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 909952002730 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 909952002731 PhoH-like protein; Region: PhoH; pfam02562 909952002732 metal-binding heat shock protein; Provisional; Region: PRK00016 909952002733 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 909952002734 Domain of unknown function DUF21; Region: DUF21; pfam01595 909952002735 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 909952002736 Transporter associated domain; Region: CorC_HlyC; smart01091 909952002737 GTPase Era; Reviewed; Region: era; PRK00089 909952002738 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 909952002739 G1 box; other site 909952002740 GTP/Mg2+ binding site [chemical binding]; other site 909952002741 Switch I region; other site 909952002742 G2 box; other site 909952002743 Switch II region; other site 909952002744 G3 box; other site 909952002745 G4 box; other site 909952002746 G5 box; other site 909952002747 KH domain; Region: KH_2; pfam07650 909952002748 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 909952002749 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 909952002750 active site 909952002751 2-isopropylmalate synthase; Validated; Region: PRK03739 909952002752 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 909952002753 active site 909952002754 catalytic residues [active] 909952002755 metal binding site [ion binding]; metal-binding site 909952002756 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 909952002757 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 909952002758 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 909952002759 catalytic residue [active] 909952002760 putative FPP diphosphate binding site; other site 909952002761 putative FPP binding hydrophobic cleft; other site 909952002762 dimer interface [polypeptide binding]; other site 909952002763 putative IPP diphosphate binding site; other site 909952002764 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 909952002765 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 909952002766 Recombination protein O N terminal; Region: RecO_N; pfam11967 909952002767 Recombination protein O C terminal; Region: RecO_C; pfam02565 909952002768 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 909952002769 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 909952002770 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 909952002771 active site 909952002772 phosphorylation site [posttranslational modification] 909952002773 intermolecular recognition site; other site 909952002774 dimerization interface [polypeptide binding]; other site 909952002775 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 909952002776 DNA binding residues [nucleotide binding] 909952002777 dimerization interface [polypeptide binding]; other site 909952002778 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 909952002779 metal binding site 2 [ion binding]; metal-binding site 909952002780 putative DNA binding helix; other site 909952002781 metal binding site 1 [ion binding]; metal-binding site 909952002782 dimer interface [polypeptide binding]; other site 909952002783 structural Zn2+ binding site [ion binding]; other site 909952002784 glycyl-tRNA synthetase; Provisional; Region: PRK04173 909952002785 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 909952002786 motif 1; other site 909952002787 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 909952002788 active site 909952002789 motif 2; other site 909952002790 motif 3; other site 909952002791 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 909952002792 anticodon binding site; other site 909952002793 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 909952002794 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 909952002795 putative Iron-sulfur protein interface [polypeptide binding]; other site 909952002796 proximal heme binding site [chemical binding]; other site 909952002797 distal heme binding site [chemical binding]; other site 909952002798 putative dimer interface [polypeptide binding]; other site 909952002799 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 909952002800 L-aspartate oxidase; Provisional; Region: PRK06175 909952002801 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 909952002802 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 909952002803 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 909952002804 4Fe-4S binding domain; Region: Fer4; pfam00037 909952002805 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 909952002806 putative FMN binding site [chemical binding]; other site 909952002807 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 909952002808 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 909952002809 putative dimer interface [polypeptide binding]; other site 909952002810 active site pocket [active] 909952002811 putative cataytic base [active] 909952002812 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 909952002813 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 909952002814 FMN binding site [chemical binding]; other site 909952002815 active site 909952002816 catalytic residues [active] 909952002817 substrate binding site [chemical binding]; other site 909952002818 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 909952002819 Zn2+ binding site [ion binding]; other site 909952002820 Mg2+ binding site [ion binding]; other site 909952002821 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 909952002822 Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424 909952002823 DNA primase; Validated; Region: dnaG; PRK05667 909952002824 CHC2 zinc finger; Region: zf-CHC2; pfam01807 909952002825 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 909952002826 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 909952002827 active site 909952002828 metal binding site [ion binding]; metal-binding site 909952002829 interdomain interaction site; other site 909952002830 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 909952002831 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 909952002832 DNA-directed RNA polymerase specialized sigma subunit [Transcription]; Region: FliA; COG1191 909952002833 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 909952002834 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 909952002835 DNA binding residues [nucleotide binding] 909952002836 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 909952002837 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 909952002838 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 909952002839 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 909952002840 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 909952002841 active site 909952002842 homotetramer interface [polypeptide binding]; other site 909952002843 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 909952002844 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 909952002845 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 909952002846 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 909952002847 dimer interface [polypeptide binding]; other site 909952002848 pyridoxal 5'-phosphate binding site [chemical binding]; other site 909952002849 catalytic residue [active] 909952002850 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 909952002851 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 909952002852 DNA-binding site [nucleotide binding]; DNA binding site 909952002853 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 909952002854 pyridoxal 5'-phosphate binding site [chemical binding]; other site 909952002855 homodimer interface [polypeptide binding]; other site 909952002856 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 909952002857 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 909952002858 active site 909952002859 multimer interface [polypeptide binding]; other site 909952002860 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 909952002861 predicted active site [active] 909952002862 catalytic triad [active] 909952002863 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 909952002864 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 909952002865 inhibitor-cofactor binding pocket; inhibition site 909952002866 pyridoxal 5'-phosphate binding site [chemical binding]; other site 909952002867 catalytic residue [active] 909952002868 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 909952002869 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 909952002870 potential protein location (hypothetical protein PAZ_c10070 [Propionibacterium acnes 266]) that overlaps RNA (tRNA-M) 909952002871 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 909952002872 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 909952002873 active site 909952002874 motif I; other site 909952002875 motif II; other site 909952002876 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 909952002877 MoxR-like ATPases [General function prediction only]; Region: COG0714 909952002878 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 909952002879 Walker A motif; other site 909952002880 ATP binding site [chemical binding]; other site 909952002881 Walker B motif; other site 909952002882 arginine finger; other site 909952002883 Protein of unknown function DUF58; Region: DUF58; pfam01882 909952002884 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 909952002885 hypothetical protein; Provisional; Region: PRK13685 909952002886 von Willebrand factor type A domain; Region: VWA_2; pfam13519 909952002887 metal ion-dependent adhesion site (MIDAS); other site 909952002888 Protein-interacting Bro1-like domain of mammalian Alix and related domains; Region: BRO1_Alix_like; cl14649 909952002889 von Willebrand factor type A domain; Region: VWA_2; pfam13519 909952002890 metal ion-dependent adhesion site (MIDAS); other site 909952002891 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 909952002892 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 909952002893 catalytic residue [active] 909952002894 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 909952002895 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 909952002896 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 909952002897 dimer interface [polypeptide binding]; other site 909952002898 active site 909952002899 acyl carrier protein; Provisional; Region: acpP; PRK00982 909952002900 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 909952002901 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 909952002902 dimer interface [polypeptide binding]; other site 909952002903 active site 909952002904 CoA binding pocket [chemical binding]; other site 909952002905 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 909952002906 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 909952002907 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 909952002908 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 909952002909 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 909952002910 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cl00252 909952002911 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 909952002912 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909952002913 putative substrate translocation pore; other site 909952002914 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909952002915 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 909952002916 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 909952002917 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 909952002918 dimer interface [polypeptide binding]; other site 909952002919 TPP-binding site [chemical binding]; other site 909952002920 Endo-beta-N-acetylglucosaminidases are bacterial chitinases that hydrolyze the chitin core of various asparagine (N)-linked glycans and glycoproteins. The endo-beta-N-acetylglucosaminidases have a glycosyl hydrolase family 18 (GH18) catalytic domain; Region: GH18_EndoS-like; cd06542 909952002921 active site 909952002922 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 909952002923 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 909952002924 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 909952002925 Isochorismatase family; Region: Isochorismatase; pfam00857 909952002926 catalytic triad [active] 909952002927 metal binding site [ion binding]; metal-binding site 909952002928 conserved cis-peptide bond; other site 909952002929 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 909952002930 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 909952002931 active site 909952002932 catalytic tetrad [active] 909952002933 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 909952002934 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 909952002935 active site 909952002936 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 909952002937 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 909952002938 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 909952002939 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 909952002940 dihydroorotase; Validated; Region: pyrC; PRK09357 909952002941 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 909952002942 active site 909952002943 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 909952002944 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 909952002945 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 909952002946 catalytic site [active] 909952002947 subunit interface [polypeptide binding]; other site 909952002948 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 909952002949 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 909952002950 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 909952002951 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 909952002952 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 909952002953 ATP-grasp domain; Region: ATP-grasp_4; cl17255 909952002954 MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245 909952002955 substrate binding site [chemical binding]; other site 909952002956 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 909952002957 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 909952002958 FAD binding pocket [chemical binding]; other site 909952002959 FAD binding motif [chemical binding]; other site 909952002960 phosphate binding motif [ion binding]; other site 909952002961 beta-alpha-beta structure motif; other site 909952002962 NAD binding pocket [chemical binding]; other site 909952002963 Iron coordination center [ion binding]; other site 909952002964 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 909952002965 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 909952002966 heterodimer interface [polypeptide binding]; other site 909952002967 active site 909952002968 FMN binding site [chemical binding]; other site 909952002969 homodimer interface [polypeptide binding]; other site 909952002970 substrate binding site [chemical binding]; other site 909952002971 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 909952002972 active site 909952002973 dimer interface [polypeptide binding]; other site 909952002974 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 909952002975 active site 909952002976 Fructosamine kinase; Region: Fructosamin_kin; cl17579 909952002977 Phosphotransferase enzyme family; Region: APH; pfam01636 909952002978 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 909952002979 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 909952002980 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 909952002981 Competence-damaged protein; Region: CinA; pfam02464 909952002982 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 909952002983 non-specific DNA binding site [nucleotide binding]; other site 909952002984 salt bridge; other site 909952002985 sequence-specific DNA binding site [nucleotide binding]; other site 909952002986 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 909952002987 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 909952002988 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 909952002989 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 909952002990 recombinase A; Provisional; Region: recA; PRK09354 909952002991 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 909952002992 hexamer interface [polypeptide binding]; other site 909952002993 Walker A motif; other site 909952002994 ATP binding site [chemical binding]; other site 909952002995 Walker B motif; other site 909952002996 recombination regulator RecX; Reviewed; Region: recX; PRK00117 909952002997 hypothetical protein; Provisional; Region: PRK12705 909952002998 KH domain; Region: KH_1; pfam00013 909952002999 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 909952003000 Zn2+ binding site [ion binding]; other site 909952003001 Mg2+ binding site [ion binding]; other site 909952003002 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 909952003003 active site 909952003004 catalytic residues [active] 909952003005 Predicted membrane protein [Function unknown]; Region: COG1288 909952003006 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 909952003007 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 909952003008 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 909952003009 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 909952003010 FeS/SAM binding site; other site 909952003011 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 909952003012 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 909952003013 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 909952003014 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 909952003015 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 909952003016 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 909952003017 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 909952003018 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 909952003019 HflX GTPase family; Region: HflX; cd01878 909952003020 G1 box; other site 909952003021 GTP/Mg2+ binding site [chemical binding]; other site 909952003022 Switch I region; other site 909952003023 G2 box; other site 909952003024 G3 box; other site 909952003025 Switch II region; other site 909952003026 G4 box; other site 909952003027 G5 box; other site 909952003028 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 909952003029 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 909952003030 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 909952003031 putative Mg++ binding site [ion binding]; other site 909952003032 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 909952003033 LexA repressor; Validated; Region: PRK00215 909952003034 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 909952003035 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 909952003036 Catalytic site [active] 909952003037 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 909952003038 ATP cone domain; Region: ATP-cone; pfam03477 909952003039 vitamin B12-dependent ribonucleotide reductase; Validated; Region: PRK06556 909952003040 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 909952003041 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 909952003042 active site 909952003043 dimer interface [polypeptide binding]; other site 909952003044 effector binding site; other site 909952003045 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 909952003046 TSCPD domain; Region: TSCPD; pfam12637 909952003047 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 909952003048 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 909952003049 Ligand Binding Site [chemical binding]; other site 909952003050 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 909952003051 Ligand Binding Site [chemical binding]; other site 909952003052 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 909952003053 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 909952003054 ATP binding site [chemical binding]; other site 909952003055 putative Mg++ binding site [ion binding]; other site 909952003056 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 909952003057 nucleotide binding region [chemical binding]; other site 909952003058 ATP-binding site [chemical binding]; other site 909952003059 Helicase associated domain (HA2); Region: HA2; pfam04408 909952003060 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 909952003061 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 909952003062 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 909952003063 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 909952003064 active site 909952003065 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 909952003066 catalytic triad [active] 909952003067 dimer interface [polypeptide binding]; other site 909952003068 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 909952003069 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 909952003070 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 909952003071 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 909952003072 Sigma-70, region 4; Region: Sigma70_r4; pfam04545 909952003073 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 909952003074 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 909952003075 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 909952003076 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 909952003077 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 909952003078 DNA binding residues [nucleotide binding] 909952003079 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 909952003080 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 909952003081 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 909952003082 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 909952003083 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 909952003084 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 909952003085 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 909952003086 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 909952003087 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 909952003088 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 909952003089 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 909952003090 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 909952003091 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 909952003092 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 909952003093 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 909952003094 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 909952003095 Mg2+ binding site [ion binding]; other site 909952003096 G-X-G motif; other site 909952003097 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 909952003098 anchoring element; other site 909952003099 dimer interface [polypeptide binding]; other site 909952003100 ATP binding site [chemical binding]; other site 909952003101 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 909952003102 active site 909952003103 metal binding site [ion binding]; metal-binding site 909952003104 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 909952003105 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 909952003106 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 909952003107 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 909952003108 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909952003109 putative substrate translocation pore; other site 909952003110 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 909952003111 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 909952003112 CAP-like domain; other site 909952003113 active site 909952003114 primary dimer interface [polypeptide binding]; other site 909952003115 Uncharacterized conserved protein [Function unknown]; Region: COG4850 909952003116 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 909952003117 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 909952003118 Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; cl17415 909952003119 thymidine kinase; Provisional; Region: PRK04296 909952003120 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 909952003121 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 909952003122 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 909952003123 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 909952003124 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 909952003125 trimer interface [polypeptide binding]; other site 909952003126 active site 909952003127 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 909952003128 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 909952003129 ssDNA binding site; other site 909952003130 generic binding surface II; other site 909952003131 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 909952003132 TrkA-N domain; Region: TrkA_N; pfam02254 909952003133 TrkA-C domain; Region: TrkA_C; pfam02080 909952003134 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 909952003135 TrkA-N domain; Region: TrkA_N; pfam02254 909952003136 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 909952003137 TRAM domain; Region: TRAM; cl01282 909952003138 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 909952003139 aconitate hydratase; Validated; Region: PRK09277 909952003140 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 909952003141 substrate binding site [chemical binding]; other site 909952003142 ligand binding site [chemical binding]; other site 909952003143 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 909952003144 substrate binding site [chemical binding]; other site 909952003145 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 909952003146 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 909952003147 TPP-binding site; other site 909952003148 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 909952003149 PYR/PP interface [polypeptide binding]; other site 909952003150 dimer interface [polypeptide binding]; other site 909952003151 TPP binding site [chemical binding]; other site 909952003152 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 909952003153 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 909952003154 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 909952003155 catalytic site [active] 909952003156 putative active site [active] 909952003157 putative substrate binding site [chemical binding]; other site 909952003158 HRDC domain; Region: HRDC; pfam00570 909952003159 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 909952003160 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 909952003161 SelR domain; Region: SelR; pfam01641 909952003162 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 909952003163 active site 909952003164 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 909952003165 YheO-like PAS domain; Region: PAS_6; pfam08348 909952003166 HTH domain; Region: HTH_22; pfam13309 909952003167 tryptophanase/L-cysteine desulfhydrase, PLP-dependent; Provisional; Region: tnaA; PRK13238 909952003168 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 909952003169 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 909952003170 catalytic residue [active] 909952003171 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 909952003172 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 909952003173 potential protein location (hypothetical protein PAZ_c11190 [Propionibacterium acnes 266]) that overlaps RNA (tRNA-V) 909952003174 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 909952003175 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 909952003176 putative NAD(P) binding site [chemical binding]; other site 909952003177 putative substrate binding site [chemical binding]; other site 909952003178 catalytic Zn binding site [ion binding]; other site 909952003179 structural Zn binding site [ion binding]; other site 909952003180 dimer interface [polypeptide binding]; other site 909952003181 LrgB-like family; Region: LrgB; cl00596 909952003182 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 909952003183 Histidine kinase; Region: HisKA_3; pfam07730 909952003184 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 909952003185 ATP binding site [chemical binding]; other site 909952003186 Mg2+ binding site [ion binding]; other site 909952003187 G-X-G motif; other site 909952003188 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 909952003189 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 909952003190 active site 909952003191 phosphorylation site [posttranslational modification] 909952003192 intermolecular recognition site; other site 909952003193 dimerization interface [polypeptide binding]; other site 909952003194 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 909952003195 DNA binding residues [nucleotide binding] 909952003196 dimerization interface [polypeptide binding]; other site 909952003197 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 909952003198 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 909952003199 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 909952003200 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 909952003201 active site 909952003202 dimer interface [polypeptide binding]; other site 909952003203 motif 1; other site 909952003204 motif 2; other site 909952003205 motif 3; other site 909952003206 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 909952003207 anticodon binding site; other site 909952003208 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 909952003209 nucleotide binding site/active site [active] 909952003210 HIT family signature motif; other site 909952003211 catalytic residue [active] 909952003212 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 909952003213 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 909952003214 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 909952003215 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 909952003216 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 909952003217 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 909952003218 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 909952003219 lipoyl attachment site [posttranslational modification]; other site 909952003220 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 909952003221 Double zinc ribbon; Region: DZR; pfam12773 909952003222 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 909952003223 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 909952003224 phosphopeptide binding site; other site 909952003225 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 909952003226 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 909952003227 DNA binding residues [nucleotide binding] 909952003228 Bifunctional nuclease; Region: DNase-RNase; pfam02577 909952003229 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 909952003230 DNA binding residues [nucleotide binding] 909952003231 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 909952003232 putative dimer interface [polypeptide binding]; other site 909952003233 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 909952003234 Major Facilitator Superfamily; Region: MFS_1; pfam07690 909952003235 pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated; Region: PRK06555 909952003236 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 909952003237 active site 909952003238 ADP/pyrophosphate binding site [chemical binding]; other site 909952003239 fructose-1,6-bisphosphate binding site; other site 909952003240 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 909952003241 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 909952003242 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 909952003243 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 909952003244 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 909952003245 Uncharacterized conserved protein [Function unknown]; Region: COG1739 909952003246 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 909952003247 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 909952003248 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 909952003249 PAC2 family; Region: PAC2; pfam09754 909952003250 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 909952003251 active site 909952003252 acyl-CoA esterase; Provisional; Region: PRK10673 909952003253 hypothetical protein; Provisional; Region: PRK03298 909952003254 DivIVA protein; Region: DivIVA; pfam05103 909952003255 V-type ATP synthase subunit E; Provisional; Region: PRK01558 909952003256 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 909952003257 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 909952003258 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 909952003259 dimer interface [polypeptide binding]; other site 909952003260 substrate binding site [chemical binding]; other site 909952003261 metal binding site [ion binding]; metal-binding site 909952003262 phosphoglucomutase; Validated; Region: PRK07564 909952003263 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 909952003264 active site 909952003265 substrate binding site [chemical binding]; other site 909952003266 metal binding site [ion binding]; metal-binding site 909952003267 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 909952003268 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 909952003269 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 909952003270 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 909952003271 motif II; other site 909952003272 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 909952003273 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 909952003274 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 909952003275 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 909952003276 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 909952003277 active site turn [active] 909952003278 phosphorylation site [posttranslational modification] 909952003279 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 909952003280 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 909952003281 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 909952003282 HPr interaction site; other site 909952003283 glycerol kinase (GK) interaction site [polypeptide binding]; other site 909952003284 active site 909952003285 phosphorylation site [posttranslational modification] 909952003286 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 909952003287 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 909952003288 nudix motif; other site 909952003289 glycogen branching enzyme; Provisional; Region: PRK12313 909952003290 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 909952003291 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 909952003292 active site 909952003293 catalytic site [active] 909952003294 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 909952003295 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 909952003296 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 909952003297 trehalose synthase; Region: treS_nterm; TIGR02456 909952003298 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 909952003299 active site 909952003300 catalytic site [active] 909952003301 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 909952003302 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 909952003303 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 909952003304 active site 909952003305 homodimer interface [polypeptide binding]; other site 909952003306 catalytic site [active] 909952003307 acceptor binding site [chemical binding]; other site 909952003308 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 909952003309 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 909952003310 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 909952003311 active site 909952003312 catalytic site [active] 909952003313 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 909952003314 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 909952003315 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 909952003316 catalytic residue [active] 909952003317 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 909952003318 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 909952003319 Ligand Binding Site [chemical binding]; other site 909952003320 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 909952003321 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 909952003322 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 909952003323 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 909952003324 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 909952003325 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 909952003326 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 909952003327 GatB domain; Region: GatB_Yqey; smart00845 909952003328 TIGR03085 family protein; Region: TIGR03085 909952003329 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 909952003330 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 909952003331 anthranilate synthase component I; Provisional; Region: PRK13571 909952003332 anthranilate synthase component I; Provisional; Region: PRK13571 909952003333 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; cl17850 909952003334 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 909952003335 active site 909952003336 ribulose/triose binding site [chemical binding]; other site 909952003337 phosphate binding site [ion binding]; other site 909952003338 substrate (anthranilate) binding pocket [chemical binding]; other site 909952003339 product (indole) binding pocket [chemical binding]; other site 909952003340 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 909952003341 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 909952003342 pyridoxal 5'-phosphate binding site [chemical binding]; other site 909952003343 catalytic residue [active] 909952003344 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 909952003345 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 909952003346 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 909952003347 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 909952003348 active site 909952003349 dimer interface [polypeptide binding]; other site 909952003350 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 909952003351 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 909952003352 active site 909952003353 FMN binding site [chemical binding]; other site 909952003354 substrate binding site [chemical binding]; other site 909952003355 3Fe-4S cluster binding site [ion binding]; other site 909952003356 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 909952003357 domain interface; other site 909952003358 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 909952003359 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 909952003360 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 909952003361 Beta-lactamase; Region: Beta-lactamase; cl17358 909952003362 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 909952003363 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 909952003364 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 909952003365 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 909952003366 putative active site [active] 909952003367 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 909952003368 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 909952003369 putative active site [active] 909952003370 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 909952003371 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 909952003372 active site turn [active] 909952003373 phosphorylation site [posttranslational modification] 909952003374 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 909952003375 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 909952003376 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 909952003377 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 909952003378 beta-galactosidase; Region: BGL; TIGR03356 909952003379 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 909952003380 active site 909952003381 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 909952003382 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 909952003383 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 909952003384 methionine cluster; other site 909952003385 active site 909952003386 phosphorylation site [posttranslational modification] 909952003387 metal binding site [ion binding]; metal-binding site 909952003388 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 909952003389 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 909952003390 active site 909952003391 PHP Thumb interface [polypeptide binding]; other site 909952003392 metal binding site [ion binding]; metal-binding site 909952003393 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 909952003394 generic binding surface II; other site 909952003395 generic binding surface I; other site 909952003396 histidinol dehydrogenase; Region: hisD; TIGR00069 909952003397 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 909952003398 NAD binding site [chemical binding]; other site 909952003399 dimerization interface [polypeptide binding]; other site 909952003400 product binding site; other site 909952003401 substrate binding site [chemical binding]; other site 909952003402 zinc binding site [ion binding]; other site 909952003403 catalytic residues [active] 909952003404 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 909952003405 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 909952003406 pyridoxal 5'-phosphate binding site [chemical binding]; other site 909952003407 homodimer interface [polypeptide binding]; other site 909952003408 catalytic residue [active] 909952003409 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 909952003410 putative active site pocket [active] 909952003411 4-fold oligomerization interface [polypeptide binding]; other site 909952003412 metal binding residues [ion binding]; metal-binding site 909952003413 3-fold/trimer interface [polypeptide binding]; other site 909952003414 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 909952003415 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 909952003416 putative active site [active] 909952003417 oxyanion strand; other site 909952003418 catalytic triad [active] 909952003419 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 909952003420 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 909952003421 catalytic residues [active] 909952003422 hypothetical protein; Validated; Region: PRK00110 909952003423 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 909952003424 active site 909952003425 putative DNA-binding cleft [nucleotide binding]; other site 909952003426 dimer interface [polypeptide binding]; other site 909952003427 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 909952003428 RuvA N terminal domain; Region: RuvA_N; pfam01330 909952003429 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 909952003430 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 909952003431 Walker A motif; other site 909952003432 ATP binding site [chemical binding]; other site 909952003433 Walker B motif; other site 909952003434 arginine finger; other site 909952003435 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 909952003436 Preprotein translocase subunit; Region: YajC; pfam02699 909952003437 Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342 909952003438 Protein export membrane protein; Region: SecD_SecF; cl14618 909952003439 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 909952003440 Protein export membrane protein; Region: SecD_SecF; pfam02355 909952003441 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 909952003442 active site 909952003443 Ion channel; Region: Ion_trans_2; pfam07885 909952003444 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 909952003445 TrkA-N domain; Region: TrkA_N; pfam02254 909952003446 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 909952003447 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 909952003448 Zn2+ binding site [ion binding]; other site 909952003449 Mg2+ binding site [ion binding]; other site 909952003450 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 909952003451 synthetase active site [active] 909952003452 NTP binding site [chemical binding]; other site 909952003453 metal binding site [ion binding]; metal-binding site 909952003454 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 909952003455 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 909952003456 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 909952003457 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 909952003458 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 909952003459 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 909952003460 histidyl-tRNA synthetase; Region: hisS; TIGR00442 909952003461 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 909952003462 dimer interface [polypeptide binding]; other site 909952003463 motif 1; other site 909952003464 active site 909952003465 motif 2; other site 909952003466 motif 3; other site 909952003467 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 909952003468 anticodon binding site; other site 909952003469 Protein of unknown function (DUF998); Region: DUF998; pfam06197 909952003470 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 909952003471 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 909952003472 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 909952003473 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 909952003474 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 909952003475 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 909952003476 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 909952003477 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 909952003478 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 909952003479 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 909952003480 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 909952003481 dimer interface [polypeptide binding]; other site 909952003482 anticodon binding site; other site 909952003483 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 909952003484 homodimer interface [polypeptide binding]; other site 909952003485 motif 1; other site 909952003486 active site 909952003487 motif 2; other site 909952003488 GAD domain; Region: GAD; pfam02938 909952003489 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 909952003490 active site 909952003491 motif 3; other site 909952003492 recombination factor protein RarA; Reviewed; Region: PRK13342 909952003493 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 909952003494 Walker A motif; other site 909952003495 ATP binding site [chemical binding]; other site 909952003496 Walker B motif; other site 909952003497 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 909952003498 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 909952003499 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 909952003500 motif 1; other site 909952003501 active site 909952003502 motif 2; other site 909952003503 motif 3; other site 909952003504 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 909952003505 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 909952003506 YceG-like family; Region: YceG; pfam02618 909952003507 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 909952003508 dimerization interface [polypeptide binding]; other site 909952003509 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 909952003510 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 909952003511 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 909952003512 shikimate binding site; other site 909952003513 NAD(P) binding site [chemical binding]; other site 909952003514 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 909952003515 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 909952003516 Tetramer interface [polypeptide binding]; other site 909952003517 active site 909952003518 FMN-binding site [chemical binding]; other site 909952003519 shikimate kinase; Reviewed; Region: aroK; PRK00131 909952003520 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 909952003521 ADP binding site [chemical binding]; other site 909952003522 magnesium binding site [ion binding]; other site 909952003523 putative shikimate binding site; other site 909952003524 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 909952003525 dimer interface [polypeptide binding]; other site 909952003526 active site 909952003527 metal binding site [ion binding]; metal-binding site 909952003528 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 909952003529 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 909952003530 putative active site [active] 909952003531 putative metal binding site [ion binding]; other site 909952003532 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 909952003533 elongation factor P; Validated; Region: PRK00529 909952003534 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 909952003535 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 909952003536 RNA binding site [nucleotide binding]; other site 909952003537 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 909952003538 RNA binding site [nucleotide binding]; other site 909952003539 transcription antitermination factor NusB; Region: nusB; TIGR01951 909952003540 putative RNA binding site [nucleotide binding]; other site 909952003541 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 909952003542 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 909952003543 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 909952003544 catalytic site [active] 909952003545 G-X2-G-X-G-K; other site 909952003546 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 909952003547 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 909952003548 Flavoprotein; Region: Flavoprotein; pfam02441 909952003549 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 909952003550 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 909952003551 S-adenosylmethionine synthetase; Validated; Region: PRK05250 909952003552 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 909952003553 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 909952003554 primosome assembly protein PriA; Provisional; Region: PRK14873 909952003555 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 909952003556 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 909952003557 putative active site [active] 909952003558 substrate binding site [chemical binding]; other site 909952003559 putative cosubstrate binding site; other site 909952003560 catalytic site [active] 909952003561 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 909952003562 substrate binding site [chemical binding]; other site 909952003563 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 909952003564 putative RNA binding site [nucleotide binding]; other site 909952003565 16S rRNA methyltransferase B; Provisional; Region: PRK14902 909952003566 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 909952003567 S-adenosylmethionine binding site [chemical binding]; other site 909952003568 CAMP factor (Cfa); Region: CAMP_factor; pfam07373 909952003569 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 909952003570 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 909952003571 substrate binding site [chemical binding]; other site 909952003572 hexamer interface [polypeptide binding]; other site 909952003573 metal binding site [ion binding]; metal-binding site 909952003574 PAC2 family; Region: PAC2; pfam09754 909952003575 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 909952003576 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 909952003577 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 909952003578 motif II; other site 909952003579 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 909952003580 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 909952003581 S-adenosylmethionine binding site [chemical binding]; other site 909952003582 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 909952003583 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 909952003584 Predicted membrane protein [Function unknown]; Region: COG1511 909952003585 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 909952003586 ABC transporter; Region: ABC_tran; pfam00005 909952003587 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 909952003588 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 909952003589 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 909952003590 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 909952003591 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 909952003592 active site 909952003593 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 909952003594 prephenate dehydrogenase; Validated; Region: PRK06545 909952003595 prephenate dehydrogenase; Validated; Region: PRK08507 909952003596 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cd02116 909952003597 cytidylate kinase; Provisional; Region: cmk; PRK00023 909952003598 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 909952003599 CMP-binding site; other site 909952003600 GTP-binding protein Der; Reviewed; Region: PRK03003 909952003601 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 909952003602 G1 box; other site 909952003603 GTP/Mg2+ binding site [chemical binding]; other site 909952003604 Switch I region; other site 909952003605 G2 box; other site 909952003606 Switch II region; other site 909952003607 G3 box; other site 909952003608 G4 box; other site 909952003609 G5 box; other site 909952003610 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 909952003611 G1 box; other site 909952003612 GTP/Mg2+ binding site [chemical binding]; other site 909952003613 Switch I region; other site 909952003614 G2 box; other site 909952003615 G3 box; other site 909952003616 Switch II region; other site 909952003617 G4 box; other site 909952003618 G5 box; other site 909952003619 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 909952003620 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 909952003621 substrate binding site [chemical binding]; other site 909952003622 dimer interface [polypeptide binding]; other site 909952003623 ATP binding site [chemical binding]; other site 909952003624 deoxyribose mutarotase_like; Region: deoxyribose_mutarotase; cd09269 909952003625 active site 909952003626 catalytic residues [active] 909952003627 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 909952003628 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909952003629 putative substrate translocation pore; other site 909952003630 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 909952003631 intersubunit interface [polypeptide binding]; other site 909952003632 active site 909952003633 catalytic residue [active] 909952003634 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 909952003635 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 909952003636 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 909952003637 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 909952003638 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 909952003639 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 909952003640 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 909952003641 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 909952003642 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 909952003643 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 909952003644 putative DNA binding site [nucleotide binding]; other site 909952003645 putative Zn2+ binding site [ion binding]; other site 909952003646 AsnC family; Region: AsnC_trans_reg; pfam01037 909952003647 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 909952003648 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 909952003649 putative active site [active] 909952003650 catalytic triad [active] 909952003651 putative dimer interface [polypeptide binding]; other site 909952003652 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 909952003653 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 909952003654 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 909952003655 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 909952003656 putative active site [active] 909952003657 putative metal binding site [ion binding]; other site 909952003658 catalytic site [active] 909952003659 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 909952003660 dimer interface [polypeptide binding]; other site 909952003661 pyridoxamine kinase; Validated; Region: PRK05756 909952003662 pyridoxal binding site [chemical binding]; other site 909952003663 ATP binding site [chemical binding]; other site 909952003664 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 909952003665 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 909952003666 non-specific DNA binding site [nucleotide binding]; other site 909952003667 salt bridge; other site 909952003668 sequence-specific DNA binding site [nucleotide binding]; other site 909952003669 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 909952003670 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 909952003671 putative active site [active] 909952003672 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 909952003673 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 909952003674 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 909952003675 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 909952003676 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 909952003677 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 909952003678 dimerization interface [polypeptide binding]; other site 909952003679 putative DNA binding site [nucleotide binding]; other site 909952003680 putative Zn2+ binding site [ion binding]; other site 909952003681 CAMP factor (Cfa); Region: CAMP_factor; pfam07373 909952003682 hypothetical protein; Provisional; Region: PRK09256 909952003683 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 909952003684 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909952003685 putative substrate translocation pore; other site 909952003686 MarR family; Region: MarR; pfam01047 909952003687 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 909952003688 Fe-S cluster binding site [ion binding]; other site 909952003689 DNA binding site [nucleotide binding] 909952003690 active site 909952003691 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 909952003692 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 909952003693 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 909952003694 gamma subunit interface [polypeptide binding]; other site 909952003695 epsilon subunit interface [polypeptide binding]; other site 909952003696 LBP interface [polypeptide binding]; other site 909952003697 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 909952003698 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 909952003699 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 909952003700 alpha subunit interaction interface [polypeptide binding]; other site 909952003701 Walker A motif; other site 909952003702 ATP binding site [chemical binding]; other site 909952003703 Walker B motif; other site 909952003704 inhibitor binding site; inhibition site 909952003705 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 909952003706 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 909952003707 core domain interface [polypeptide binding]; other site 909952003708 delta subunit interface [polypeptide binding]; other site 909952003709 epsilon subunit interface [polypeptide binding]; other site 909952003710 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 909952003711 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 909952003712 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 909952003713 beta subunit interaction interface [polypeptide binding]; other site 909952003714 Walker A motif; other site 909952003715 ATP binding site [chemical binding]; other site 909952003716 Walker B motif; other site 909952003717 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 909952003718 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210 909952003719 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 909952003720 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 909952003721 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 909952003722 F0F1 ATP synthase subunit C; Validated; Region: PRK07558 909952003723 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 909952003724 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 909952003725 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754 909952003726 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 909952003727 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 909952003728 putative catalytic motif [active] 909952003729 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 909952003730 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 909952003731 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 909952003732 S-adenosylmethionine binding site [chemical binding]; other site 909952003733 peptide chain release factor 1; Validated; Region: prfA; PRK00591 909952003734 PCRF domain; Region: PCRF; pfam03462 909952003735 RF-1 domain; Region: RF-1; pfam00472 909952003736 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 909952003737 transcription termination factor Rho; Provisional; Region: PRK12678 909952003738 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 909952003739 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 909952003740 RNA binding site [nucleotide binding]; other site 909952003741 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 909952003742 Walker A motif; other site 909952003743 ATP binding site [chemical binding]; other site 909952003744 Walker B motif; other site 909952003745 homoserine kinase; Provisional; Region: PRK01212 909952003746 threonine synthase; Reviewed; Region: PRK06721 909952003747 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 909952003748 homodimer interface [polypeptide binding]; other site 909952003749 pyridoxal 5'-phosphate binding site [chemical binding]; other site 909952003750 catalytic residue [active] 909952003751 homoserine dehydrogenase; Provisional; Region: PRK06349 909952003752 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 909952003753 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 909952003754 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 909952003755 diaminopimelate decarboxylase; Region: lysA; TIGR01048 909952003756 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 909952003757 active site 909952003758 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 909952003759 substrate binding site [chemical binding]; other site 909952003760 catalytic residues [active] 909952003761 dimer interface [polypeptide binding]; other site 909952003762 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 909952003763 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 909952003764 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 909952003765 TPP-binding site [chemical binding]; other site 909952003766 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 909952003767 Transcription factor WhiB; Region: Whib; pfam02467 909952003768 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 909952003769 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 909952003770 Histidine kinase; Region: HisKA_2; pfam07568 909952003771 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 909952003772 ATP binding site [chemical binding]; other site 909952003773 Mg2+ binding site [ion binding]; other site 909952003774 G-X-G motif; other site 909952003775 anti-sigma factor, TIGR02949 family; Region: anti_SigH_actin 909952003776 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 909952003777 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 909952003778 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 909952003779 DNA binding residues [nucleotide binding] 909952003780 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 909952003781 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 909952003782 hinge; other site 909952003783 active site 909952003784 Predicted GTPases [General function prediction only]; Region: COG1162 909952003785 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 909952003786 GTPase/Zn-binding domain interface [polypeptide binding]; other site 909952003787 GTP/Mg2+ binding site [chemical binding]; other site 909952003788 G4 box; other site 909952003789 G5 box; other site 909952003790 G1 box; other site 909952003791 Switch I region; other site 909952003792 G2 box; other site 909952003793 G3 box; other site 909952003794 Switch II region; other site 909952003795 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 909952003796 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 909952003797 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 909952003798 active site 909952003799 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 909952003800 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 909952003801 ligand binding site [chemical binding]; other site 909952003802 NAD binding site [chemical binding]; other site 909952003803 tetramer interface [polypeptide binding]; other site 909952003804 catalytic site [active] 909952003805 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 909952003806 L-serine binding site [chemical binding]; other site 909952003807 ACT domain interface; other site 909952003808 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 909952003809 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 909952003810 Walker A/P-loop; other site 909952003811 ATP binding site [chemical binding]; other site 909952003812 Q-loop/lid; other site 909952003813 ABC transporter signature motif; other site 909952003814 Walker B; other site 909952003815 D-loop; other site 909952003816 H-loop/switch region; other site 909952003817 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 909952003818 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 909952003819 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 909952003820 Walker A/P-loop; other site 909952003821 ATP binding site [chemical binding]; other site 909952003822 Q-loop/lid; other site 909952003823 ABC transporter signature motif; other site 909952003824 Walker B; other site 909952003825 D-loop; other site 909952003826 H-loop/switch region; other site 909952003827 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 909952003828 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 909952003829 dimer interface [polypeptide binding]; other site 909952003830 conserved gate region; other site 909952003831 putative PBP binding loops; other site 909952003832 ABC-ATPase subunit interface; other site 909952003833 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 909952003834 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 909952003835 dimer interface [polypeptide binding]; other site 909952003836 conserved gate region; other site 909952003837 putative PBP binding loops; other site 909952003838 ABC-ATPase subunit interface; other site 909952003839 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 909952003840 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 909952003841 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 909952003842 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 909952003843 Magnesium ion binding site [ion binding]; other site 909952003844 Domain of unknown function (DUF929); Region: DUF929; pfam06053 909952003845 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 909952003846 Thioesterase domain; Region: Thioesterase; pfam00975 909952003847 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 909952003848 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 909952003849 AMP binding site [chemical binding]; other site 909952003850 active site 909952003851 acyl-activating enzyme (AAE) consensus motif; other site 909952003852 CoA binding site [chemical binding]; other site 909952003853 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 909952003854 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 909952003855 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 909952003856 acyl-activating enzyme (AAE) consensus motif; other site 909952003857 AMP binding site [chemical binding]; other site 909952003858 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 909952003859 Condensation domain; Region: Condensation; pfam00668 909952003860 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 909952003861 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 909952003862 2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944 909952003863 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 909952003864 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 909952003865 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 909952003866 dimer interface [polypeptide binding]; other site 909952003867 pyridoxal 5'-phosphate binding site [chemical binding]; other site 909952003868 catalytic residue [active] 909952003869 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 909952003870 ParB-like nuclease domain; Region: ParBc; cl02129 909952003871 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 909952003872 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 909952003873 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 909952003874 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 909952003875 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 909952003876 Ligand Binding Site [chemical binding]; other site 909952003877 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 909952003878 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 909952003879 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 909952003880 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 909952003881 Protein of unknown function DUF45; Region: DUF45; pfam01863 909952003882 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 909952003883 Part of AAA domain; Region: AAA_19; pfam13245 909952003884 Family description; Region: UvrD_C_2; pfam13538 909952003885 HRDC domain; Region: HRDC; pfam00570 909952003886 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 909952003887 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 909952003888 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 909952003889 Part of AAA domain; Region: AAA_19; pfam13245 909952003890 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 909952003891 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 909952003892 AAA domain; Region: AAA_30; pfam13604 909952003893 Family description; Region: UvrD_C_2; pfam13538 909952003894 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 909952003895 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 909952003896 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 909952003897 putative NADH binding site [chemical binding]; other site 909952003898 putative active site [active] 909952003899 nudix motif; other site 909952003900 putative metal binding site [ion binding]; other site 909952003901 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 909952003902 Part of AAA domain; Region: AAA_19; pfam13245 909952003903 Family description; Region: UvrD_C_2; pfam13538 909952003904 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 909952003905 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 909952003906 Part of AAA domain; Region: AAA_19; pfam13245 909952003907 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 909952003908 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 909952003909 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 909952003910 active site 909952003911 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 909952003912 tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like; Region: MiaE_2; pfam13794 909952003913 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 909952003914 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 909952003915 ATP binding site [chemical binding]; other site 909952003916 Mg++ binding site [ion binding]; other site 909952003917 motif III; other site 909952003918 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 909952003919 nucleotide binding region [chemical binding]; other site 909952003920 ATP-binding site [chemical binding]; other site 909952003921 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 909952003922 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 909952003923 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 909952003924 active site 909952003925 HIGH motif; other site 909952003926 dimer interface [polypeptide binding]; other site 909952003927 KMSKS motif; other site 909952003928 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 909952003929 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 909952003930 active site 909952003931 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 909952003932 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 909952003933 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 909952003934 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 909952003935 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 909952003936 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 909952003937 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 909952003938 30S subunit binding site; other site 909952003939 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 909952003940 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 909952003941 active site 909952003942 Sporulation and spore germination; Region: Germane; cl11253 909952003943 Lipoprotein LpqB beta-propeller domain; Region: Gmad1; pfam10647 909952003944 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 909952003945 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 909952003946 dimerization interface [polypeptide binding]; other site 909952003947 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 909952003948 dimer interface [polypeptide binding]; other site 909952003949 phosphorylation site [posttranslational modification] 909952003950 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 909952003951 ATP binding site [chemical binding]; other site 909952003952 Mg2+ binding site [ion binding]; other site 909952003953 G-X-G motif; other site 909952003954 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 909952003955 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 909952003956 active site 909952003957 phosphorylation site [posttranslational modification] 909952003958 intermolecular recognition site; other site 909952003959 dimerization interface [polypeptide binding]; other site 909952003960 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 909952003961 DNA binding site [nucleotide binding] 909952003962 hypothetical protein; Validated; Region: PRK00228 909952003963 CAMP factor (Cfa); Region: CAMP_factor; pfam07373 909952003964 ribbon-helix-helix domain containing protein; Region: PHA00617 909952003965 Protein of unknown function (DUF1706); Region: DUF1706; cl01748 909952003966 Protein of unknown function (DUF1706); Region: DUF1706; cl01748 909952003967 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 909952003968 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 909952003969 Tic20-like protein; Region: Tic20; pfam09685 909952003970 argininosuccinate lyase; Provisional; Region: PRK00855 909952003971 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 909952003972 active sites [active] 909952003973 tetramer interface [polypeptide binding]; other site 909952003974 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 909952003975 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 909952003976 inhibitor-cofactor binding pocket; inhibition site 909952003977 pyridoxal 5'-phosphate binding site [chemical binding]; other site 909952003978 catalytic residue [active] 909952003979 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 909952003980 feedback inhibition sensing region; other site 909952003981 homohexameric interface [polypeptide binding]; other site 909952003982 nucleotide binding site [chemical binding]; other site 909952003983 N-acetyl-L-glutamate binding site [chemical binding]; other site 909952003984 DmpA/OAT superfamily; composed of L-aminopeptidase D-amidase/D-esterase (DmpA), ornithine acetyltransferase (OAT) and similar proteins. DmpA is an aminopeptidase that releases N-terminal D and L amino acids from peptide substrates. This group represents...; Region: DmpA_OAT; cl00603 909952003985 DmpA/OAT superfamily; composed of L-aminopeptidase D-amidase/D-esterase (DmpA), ornithine acetyltransferase (OAT) and similar proteins. DmpA is an aminopeptidase that releases N-terminal D and L amino acids from peptide substrates. This group represents...; Region: DmpA_OAT; cl00603 909952003986 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 909952003987 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 909952003988 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 909952003989 SmpB-tmRNA interface; other site 909952003990 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 909952003991 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 909952003992 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 909952003993 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 909952003994 Walker A/P-loop; other site 909952003995 ATP binding site [chemical binding]; other site 909952003996 Q-loop/lid; other site 909952003997 ABC transporter signature motif; other site 909952003998 Walker B; other site 909952003999 D-loop; other site 909952004000 H-loop/switch region; other site 909952004001 peptide chain release factor 2; Validated; Region: prfB; PRK00578 909952004002 This domain is found in peptide chain release factors; Region: PCRF; smart00937 909952004003 RF-1 domain; Region: RF-1; pfam00472 909952004004 Protein of unknown function (DUF805); Region: DUF805; pfam05656 909952004005 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 909952004006 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 909952004007 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 909952004008 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 909952004009 thiamine monophosphate kinase; Provisional; Region: PRK05731 909952004010 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 909952004011 ATP binding site [chemical binding]; other site 909952004012 dimerization interface [polypeptide binding]; other site 909952004013 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 909952004014 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 909952004015 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 909952004016 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 909952004017 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 909952004018 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 909952004019 putative acyl-acceptor binding pocket; other site 909952004020 hypothetical protein; Provisional; Region: PRK14812 909952004021 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 909952004022 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 909952004023 Transcriptional regulator [Transcription]; Region: IclR; COG1414 909952004024 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 909952004025 Bacterial transcriptional regulator; Region: IclR; pfam01614 909952004026 CAAX protease self-immunity; Region: Abi; pfam02517 909952004027 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 909952004028 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 909952004029 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 909952004030 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 909952004031 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 909952004032 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 909952004033 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 909952004034 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 909952004035 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 909952004036 homodimer interface [polypeptide binding]; other site 909952004037 substrate-cofactor binding pocket; other site 909952004038 catalytic residue [active] 909952004039 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 909952004040 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 909952004041 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 909952004042 ketol-acid reductoisomerase; Provisional; Region: PRK05479 909952004043 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 909952004044 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 909952004045 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 909952004046 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 909952004047 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 909952004048 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 909952004049 HIT family signature motif; other site 909952004050 catalytic residue [active] 909952004051 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 909952004052 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 909952004053 substrate binding site [chemical binding]; other site 909952004054 glutamase interaction surface [polypeptide binding]; other site 909952004055 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 909952004056 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 909952004057 ATP binding site [chemical binding]; other site 909952004058 putative Mg++ binding site [ion binding]; other site 909952004059 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 909952004060 nucleotide binding region [chemical binding]; other site 909952004061 ATP-binding site [chemical binding]; other site 909952004062 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 909952004063 Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902 909952004064 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 909952004065 Predicted transcriptional regulator [Transcription]; Region: COG2378 909952004066 WYL domain; Region: WYL; pfam13280 909952004067 Predicted transcriptional regulator [Transcription]; Region: COG2378 909952004068 WYL domain; Region: WYL; pfam13280 909952004069 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 909952004070 active site 909952004071 KMSKS motif; other site 909952004072 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 909952004073 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 909952004074 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 909952004075 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 909952004076 RNA binding surface [nucleotide binding]; other site 909952004077 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 909952004078 active site 909952004079 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 909952004080 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 909952004081 P-loop; other site 909952004082 Magnesium ion binding site [ion binding]; other site 909952004083 transport-energizing ATPase, TRC40/GET3/ArsA family; Region: GET3_arsA_TRC40; TIGR00345 909952004084 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 909952004085 Magnesium ion binding site [ion binding]; other site 909952004086 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 909952004087 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 909952004088 active site 909952004089 Int/Topo IB signature motif; other site 909952004090 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 909952004091 dimer interface [polypeptide binding]; other site 909952004092 ADP-ribose binding site [chemical binding]; other site 909952004093 active site 909952004094 nudix motif; other site 909952004095 metal binding site [ion binding]; metal-binding site 909952004096 CTP synthetase; Validated; Region: pyrG; PRK05380 909952004097 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 909952004098 Catalytic site [active] 909952004099 active site 909952004100 UTP binding site [chemical binding]; other site 909952004101 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 909952004102 active site 909952004103 putative oxyanion hole; other site 909952004104 catalytic triad [active] 909952004105 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 909952004106 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 909952004107 Walker A/P-loop; other site 909952004108 ATP binding site [chemical binding]; other site 909952004109 Q-loop/lid; other site 909952004110 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 909952004111 ABC transporter signature motif; other site 909952004112 Walker B; other site 909952004113 D-loop; other site 909952004114 H-loop/switch region; other site 909952004115 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 909952004116 ATP-NAD kinase; Region: NAD_kinase; pfam01513 909952004117 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 909952004118 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 909952004119 RNA binding surface [nucleotide binding]; other site 909952004120 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 909952004121 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 909952004122 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 909952004123 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 909952004124 Walker A/P-loop; other site 909952004125 ATP binding site [chemical binding]; other site 909952004126 Q-loop/lid; other site 909952004127 ABC transporter signature motif; other site 909952004128 Walker B; other site 909952004129 D-loop; other site 909952004130 H-loop/switch region; other site 909952004131 BioY family; Region: BioY; pfam02632 909952004132 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 909952004133 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 909952004134 active site 909952004135 motif I; other site 909952004136 motif II; other site 909952004137 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 909952004138 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 909952004139 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 909952004140 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 909952004141 active site 909952004142 HIGH motif; other site 909952004143 dimer interface [polypeptide binding]; other site 909952004144 KMSKS motif; other site 909952004145 arginine repressor; Provisional; Region: PRK03341 909952004146 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 909952004147 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 909952004148 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 909952004149 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 909952004150 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 909952004151 biotin synthase; Validated; Region: PRK06256 909952004152 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 909952004153 FeS/SAM binding site; other site 909952004154 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 909952004155 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 909952004156 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 909952004157 putative tRNA-binding site [nucleotide binding]; other site 909952004158 B3/4 domain; Region: B3_4; pfam03483 909952004159 tRNA synthetase B5 domain; Region: B5; pfam03484 909952004160 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 909952004161 dimer interface [polypeptide binding]; other site 909952004162 motif 1; other site 909952004163 motif 3; other site 909952004164 motif 2; other site 909952004165 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 909952004166 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 909952004167 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 909952004168 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 909952004169 dimer interface [polypeptide binding]; other site 909952004170 motif 1; other site 909952004171 active site 909952004172 motif 2; other site 909952004173 motif 3; other site 909952004174 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 909952004175 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 909952004176 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 909952004177 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 909952004178 23S rRNA binding site [nucleotide binding]; other site 909952004179 L21 binding site [polypeptide binding]; other site 909952004180 L13 binding site [polypeptide binding]; other site 909952004181 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 909952004182 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 909952004183 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 909952004184 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 909952004185 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 909952004186 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 909952004187 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 909952004188 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 909952004189 homodimer interface [polypeptide binding]; other site 909952004190 putative metal binding site [ion binding]; other site 909952004191 Nicotinamide mononucleotide transporter [Coenzyme metabolism]; Region: PnuC; COG3201 909952004192 conserved hypothetical protein; Region: TIGR03843 909952004193 conserved hypothetical protein; Region: TIGR03847 909952004194 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 909952004195 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 909952004196 active site 909952004197 catalytic tetrad [active] 909952004198 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 909952004199 dimer interface [polypeptide binding]; other site 909952004200 Citrate synthase; Region: Citrate_synt; pfam00285 909952004201 active site 909952004202 citrylCoA binding site [chemical binding]; other site 909952004203 NADH binding [chemical binding]; other site 909952004204 cationic pore residues; other site 909952004205 oxalacetate/citrate binding site [chemical binding]; other site 909952004206 coenzyme A binding site [chemical binding]; other site 909952004207 catalytic triad [active] 909952004208 hypothetical protein; Provisional; Region: PRK07906 909952004209 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 909952004210 putative metal binding site [ion binding]; other site 909952004211 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 909952004212 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 909952004213 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 909952004214 CsbD-like; Region: CsbD; pfam05532 909952004215 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 909952004216 DNA protecting protein DprA; Region: dprA; TIGR00732 909952004217 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 909952004218 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 909952004219 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 909952004220 Walker A motif; other site 909952004221 ATP binding site [chemical binding]; other site 909952004222 Walker B motif; other site 909952004223 arginine finger; other site 909952004224 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 909952004225 hypothetical protein; Reviewed; Region: PRK12497 909952004226 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 909952004227 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 909952004228 RNA/DNA hybrid binding site [nucleotide binding]; other site 909952004229 active site 909952004230 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 909952004231 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 909952004232 Catalytic site [active] 909952004233 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 909952004234 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 909952004235 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 909952004236 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 909952004237 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 909952004238 L-aspartate oxidase; Provisional; Region: PRK06175 909952004239 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 909952004240 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 909952004241 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 909952004242 putative Iron-sulfur protein interface [polypeptide binding]; other site 909952004243 proximal heme binding site [chemical binding]; other site 909952004244 distal heme binding site [chemical binding]; other site 909952004245 putative dimer interface [polypeptide binding]; other site 909952004246 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 909952004247 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 909952004248 RimM N-terminal domain; Region: RimM; pfam01782 909952004249 PRC-barrel domain; Region: PRC; pfam05239 909952004250 hypothetical protein; Provisional; Region: PRK02821 909952004251 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 909952004252 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 909952004253 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 909952004254 Amidohydrolase; Region: Amidohydro_4; pfam13147 909952004255 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 909952004256 active site 909952004257 signal recognition particle protein; Provisional; Region: PRK10867 909952004258 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 909952004259 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 909952004260 P loop; other site 909952004261 GTP binding site [chemical binding]; other site 909952004262 Signal peptide binding domain; Region: SRP_SPB; pfam02978 909952004263 Predicted esterase [General function prediction only]; Region: COG0627 909952004264 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 909952004265 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 909952004266 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 909952004267 P loop; other site 909952004268 GTP binding site [chemical binding]; other site 909952004269 Predicted membrane protein [Function unknown]; Region: COG2246 909952004270 GtrA-like protein; Region: GtrA; pfam04138 909952004271 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 909952004272 HicB family; Region: HicB; pfam05534 909952004273 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 909952004274 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 909952004275 DNA binding site [nucleotide binding] 909952004276 H2TH interface [polypeptide binding]; other site 909952004277 putative catalytic residues [active] 909952004278 turnover-facilitating residue; other site 909952004279 intercalation triad [nucleotide binding]; other site 909952004280 8OG recognition residue [nucleotide binding]; other site 909952004281 putative reading head residues; other site 909952004282 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 909952004283 ribonuclease III; Reviewed; Region: rnc; PRK00102 909952004284 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 909952004285 dimerization interface [polypeptide binding]; other site 909952004286 active site 909952004287 metal binding site [ion binding]; metal-binding site 909952004288 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 909952004289 dsRNA binding site [nucleotide binding]; other site 909952004290 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 909952004291 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 909952004292 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 909952004293 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 909952004294 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 909952004295 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 909952004296 dimer interface [polypeptide binding]; other site 909952004297 conserved gate region; other site 909952004298 putative PBP binding loops; other site 909952004299 ABC-ATPase subunit interface; other site 909952004300 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 909952004301 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 909952004302 dimer interface [polypeptide binding]; other site 909952004303 conserved gate region; other site 909952004304 putative PBP binding loops; other site 909952004305 ABC-ATPase subunit interface; other site 909952004306 Transcriptional regulators [Transcription]; Region: PurR; COG1609 909952004307 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 909952004308 DNA binding site [nucleotide binding] 909952004309 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 909952004310 ligand binding site [chemical binding]; other site 909952004311 dimerization interface [polypeptide binding]; other site 909952004312 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 909952004313 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 909952004314 active site 909952004315 catalytic site [active] 909952004316 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; pfam09261 909952004317 Endo-beta-mannanase [Carbohydrate transport and metabolism]; Region: COG3934 909952004318 Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565 909952004319 putative active site [active] 909952004320 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 909952004321 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 909952004322 conserved gate region; other site 909952004323 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 909952004324 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 909952004325 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 909952004326 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 909952004327 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 909952004328 dimer interface [polypeptide binding]; other site 909952004329 conserved gate region; other site 909952004330 putative PBP binding loops; other site 909952004331 ABC-ATPase subunit interface; other site 909952004332 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 909952004333 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 909952004334 Walker A/P-loop; other site 909952004335 ATP binding site [chemical binding]; other site 909952004336 Q-loop/lid; other site 909952004337 ABC transporter signature motif; other site 909952004338 Walker B; other site 909952004339 D-loop; other site 909952004340 H-loop/switch region; other site 909952004341 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 909952004342 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 909952004343 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 909952004344 Walker A/P-loop; other site 909952004345 ATP binding site [chemical binding]; other site 909952004346 Q-loop/lid; other site 909952004347 ABC transporter signature motif; other site 909952004348 Walker B; other site 909952004349 D-loop; other site 909952004350 H-loop/switch region; other site 909952004351 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 909952004352 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 909952004353 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 909952004354 substrate binding site [chemical binding]; other site 909952004355 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 909952004356 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 909952004357 active site 909952004358 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 909952004359 active site 909952004360 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 909952004361 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 909952004362 active site 909952004363 (T/H)XGH motif; other site 909952004364 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 909952004365 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 909952004366 S-adenosylmethionine binding site [chemical binding]; other site 909952004367 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 909952004368 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 909952004369 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 909952004370 ssDNA binding site; other site 909952004371 generic binding surface II; other site 909952004372 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 909952004373 ATP binding site [chemical binding]; other site 909952004374 putative Mg++ binding site [ion binding]; other site 909952004375 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 909952004376 nucleotide binding region [chemical binding]; other site 909952004377 ATP-binding site [chemical binding]; other site 909952004378 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 909952004379 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 909952004380 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 909952004381 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 909952004382 pyruvate dehydrogenase; Provisional; Region: PRK06546 909952004383 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 909952004384 PYR/PP interface [polypeptide binding]; other site 909952004385 dimer interface [polypeptide binding]; other site 909952004386 tetramer interface [polypeptide binding]; other site 909952004387 TPP binding site [chemical binding]; other site 909952004388 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 909952004389 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 909952004390 TPP-binding site [chemical binding]; other site 909952004391 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 909952004392 dihydrodipicolinate reductase; Provisional; Region: PRK00048 909952004393 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 909952004394 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 909952004395 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 909952004396 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 909952004397 oligomer interface [polypeptide binding]; other site 909952004398 RNA binding site [nucleotide binding]; other site 909952004399 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 909952004400 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 909952004401 RNase E interface [polypeptide binding]; other site 909952004402 trimer interface [polypeptide binding]; other site 909952004403 active site 909952004404 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 909952004405 putative nucleic acid binding region [nucleotide binding]; other site 909952004406 G-X-X-G motif; other site 909952004407 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 909952004408 RNA binding site [nucleotide binding]; other site 909952004409 domain interface; other site 909952004410 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 909952004411 16S/18S rRNA binding site [nucleotide binding]; other site 909952004412 S13e-L30e interaction site [polypeptide binding]; other site 909952004413 25S rRNA binding site [nucleotide binding]; other site 909952004414 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 909952004415 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 909952004416 active site 909952004417 Riboflavin kinase; Region: Flavokinase; smart00904 909952004418 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 909952004419 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 909952004420 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 909952004421 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 909952004422 dimer interface [polypeptide binding]; other site 909952004423 conserved gate region; other site 909952004424 ABC-ATPase subunit interface; other site 909952004425 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 909952004426 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 909952004427 Walker A/P-loop; other site 909952004428 ATP binding site [chemical binding]; other site 909952004429 Q-loop/lid; other site 909952004430 ABC transporter signature motif; other site 909952004431 Walker B; other site 909952004432 D-loop; other site 909952004433 H-loop/switch region; other site 909952004434 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 909952004435 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 909952004436 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 909952004437 RNA binding site [nucleotide binding]; other site 909952004438 active site 909952004439 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 909952004440 Cupin domain; Region: Cupin_2; cl17218 909952004441 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 909952004442 HTH domain; Region: HTH_11; pfam08279 909952004443 HTH domain; Region: HTH_11; pfam08279 909952004444 PRD domain; Region: PRD; pfam00874 909952004445 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 909952004446 active site 909952004447 P-loop; other site 909952004448 phosphorylation site [posttranslational modification] 909952004449 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359 909952004450 active site 909952004451 phosphorylation site [posttranslational modification] 909952004452 Glucitol operon activator protein (GutM); Region: GutM; pfam06923 909952004453 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; pfam03608 909952004454 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 909952004455 PTS system, glucitol/sorbitol-specific, IIBC component; Region: EIIBC-GUT; TIGR00825 909952004456 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 909952004457 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829 909952004458 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 909952004459 dimerization domain swap beta strand [polypeptide binding]; other site 909952004460 regulatory protein interface [polypeptide binding]; other site 909952004461 active site 909952004462 regulatory phosphorylation site [posttranslational modification]; other site 909952004463 Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175 909952004464 active site 909952004465 metal binding site [ion binding]; metal-binding site 909952004466 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 909952004467 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 909952004468 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 909952004469 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 909952004470 Walker A/P-loop; other site 909952004471 ATP binding site [chemical binding]; other site 909952004472 Q-loop/lid; other site 909952004473 ABC transporter signature motif; other site 909952004474 Walker B; other site 909952004475 D-loop; other site 909952004476 H-loop/switch region; other site 909952004477 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 909952004478 translation initiation factor IF-2; Region: IF-2; TIGR00487 909952004479 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 909952004480 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 909952004481 G1 box; other site 909952004482 putative GEF interaction site [polypeptide binding]; other site 909952004483 GTP/Mg2+ binding site [chemical binding]; other site 909952004484 Switch I region; other site 909952004485 G2 box; other site 909952004486 G3 box; other site 909952004487 Switch II region; other site 909952004488 G4 box; other site 909952004489 G5 box; other site 909952004490 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 909952004491 Translation-initiation factor 2; Region: IF-2; pfam11987 909952004492 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 909952004493 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 909952004494 NusA N-terminal domain; Region: NusA_N; pfam08529 909952004495 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 909952004496 RNA binding site [nucleotide binding]; other site 909952004497 homodimer interface [polypeptide binding]; other site 909952004498 NusA-like KH domain; Region: KH_5; pfam13184 909952004499 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 909952004500 G-X-X-G motif; other site 909952004501 ribosome maturation protein RimP; Reviewed; Region: PRK00092 909952004502 Sm and related proteins; Region: Sm_like; cl00259 909952004503 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 909952004504 putative oligomer interface [polypeptide binding]; other site 909952004505 putative RNA binding site [nucleotide binding]; other site 909952004506 hypothetical protein; Provisional; Region: PRK10621 909952004507 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 909952004508 metallophosphoesterase, PPA1498 family; Region: P_acnes_RR; TIGR03767 909952004509 prolyl-tRNA synthetase; Provisional; Region: PRK09194 909952004510 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 909952004511 dimer interface [polypeptide binding]; other site 909952004512 motif 1; other site 909952004513 active site 909952004514 motif 2; other site 909952004515 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 909952004516 putative deacylase active site [active] 909952004517 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 909952004518 active site 909952004519 motif 3; other site 909952004520 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 909952004521 anticodon binding site; other site 909952004522 putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773 909952004523 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 909952004524 putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773 909952004525 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 909952004526 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 909952004527 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 909952004528 anchored repeat ABC transporter, substrate-binding protein; Region: anch_rpt_subst; TIGR03772 909952004529 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 909952004530 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 909952004531 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 909952004532 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 909952004533 anchored repeat-type ABC transporter, ATP-binding subunit; Region: anch_rpt_ABC; TIGR03771 909952004534 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 909952004535 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 909952004536 ABC-ATPase subunit interface; other site 909952004537 dimer interface [polypeptide binding]; other site 909952004538 putative PBP binding regions; other site 909952004539 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 909952004540 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 909952004541 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 909952004542 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 909952004543 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 909952004544 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 909952004545 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 909952004546 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 909952004547 active site 909952004548 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 909952004549 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 909952004550 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 909952004551 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 909952004552 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 909952004553 Beta-lactamase; Region: Beta-lactamase; pfam00144 909952004554 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 909952004555 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 909952004556 glutamate dehydrogenase; Provisional; Region: PRK09414 909952004557 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 909952004558 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 909952004559 NAD(P) binding site [chemical binding]; other site 909952004560 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 909952004561 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 909952004562 FeS/SAM binding site; other site 909952004563 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 909952004564 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 909952004565 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 909952004566 ribosome recycling factor; Reviewed; Region: frr; PRK00083 909952004567 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 909952004568 hinge region; other site 909952004569 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 909952004570 putative nucleotide binding site [chemical binding]; other site 909952004571 uridine monophosphate binding site [chemical binding]; other site 909952004572 homohexameric interface [polypeptide binding]; other site 909952004573 elongation factor Ts; Provisional; Region: tsf; PRK09377 909952004574 UBA/TS-N domain; Region: UBA; pfam00627 909952004575 Elongation factor TS; Region: EF_TS; pfam00889 909952004576 Elongation factor TS; Region: EF_TS; pfam00889 909952004577 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 909952004578 rRNA interaction site [nucleotide binding]; other site 909952004579 S8 interaction site; other site 909952004580 putative laminin-1 binding site; other site 909952004581 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 909952004582 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 909952004583 active site 909952004584 DNA binding site [nucleotide binding] 909952004585 Int/Topo IB signature motif; other site 909952004586 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 909952004587 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 909952004588 active site 909952004589 catalytic residues [active] 909952004590 metal binding site [ion binding]; metal-binding site 909952004591 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 909952004592 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 909952004593 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 909952004594 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 909952004595 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 909952004596 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 909952004597 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 909952004598 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 909952004599 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 909952004600 Walker A/P-loop; other site 909952004601 ATP binding site [chemical binding]; other site 909952004602 Q-loop/lid; other site 909952004603 ABC transporter signature motif; other site 909952004604 Walker B; other site 909952004605 D-loop; other site 909952004606 H-loop/switch region; other site 909952004607 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 909952004608 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 909952004609 NAD(P) binding site [chemical binding]; other site 909952004610 active site 909952004611 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 909952004612 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 909952004613 NAD(P) binding site [chemical binding]; other site 909952004614 active site 909952004615 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 909952004616 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 909952004617 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 909952004618 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 909952004619 S-adenosylmethionine binding site [chemical binding]; other site 909952004620 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 909952004621 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 909952004622 Walker A/P-loop; other site 909952004623 ATP binding site [chemical binding]; other site 909952004624 Q-loop/lid; other site 909952004625 ABC transporter signature motif; other site 909952004626 Walker B; other site 909952004627 D-loop; other site 909952004628 H-loop/switch region; other site 909952004629 ABC transporter; Region: ABC_tran_2; pfam12848 909952004630 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 909952004631 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 909952004632 Coenzyme A binding pocket [chemical binding]; other site 909952004633 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 909952004634 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 909952004635 phosphate binding site [ion binding]; other site 909952004636 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 909952004637 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 909952004638 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 909952004639 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 909952004640 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 909952004641 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 909952004642 trimerization site [polypeptide binding]; other site 909952004643 active site 909952004644 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 909952004645 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 909952004646 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 909952004647 catalytic residue [active] 909952004648 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 909952004649 FeS assembly ATPase SufC; Region: sufC; TIGR01978 909952004650 Walker A/P-loop; other site 909952004651 ATP binding site [chemical binding]; other site 909952004652 Q-loop/lid; other site 909952004653 ABC transporter signature motif; other site 909952004654 Walker B; other site 909952004655 D-loop; other site 909952004656 H-loop/switch region; other site 909952004657 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 909952004658 [2Fe-2S] cluster binding site [ion binding]; other site 909952004659 FeS assembly protein SufD; Region: sufD; TIGR01981 909952004660 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 909952004661 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 909952004662 FeS assembly protein SufB; Region: sufB; TIGR01980 909952004663 iron-sulfur cluster biosynthesis transcriptional regulator SufR; Region: SufR_cyano; TIGR02702 909952004664 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 909952004665 putative DNA binding site [nucleotide binding]; other site 909952004666 putative Zn2+ binding site [ion binding]; other site 909952004667 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 909952004668 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 909952004669 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 909952004670 dimer interface [polypeptide binding]; other site 909952004671 conserved gate region; other site 909952004672 putative PBP binding loops; other site 909952004673 ABC-ATPase subunit interface; other site 909952004674 Transcriptional regulators [Transcription]; Region: PurR; COG1609 909952004675 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 909952004676 DNA binding site [nucleotide binding] 909952004677 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_10; cd06292 909952004678 putative dimerization interface [polypeptide binding]; other site 909952004679 putative ligand binding site [chemical binding]; other site 909952004680 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 909952004681 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 909952004682 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 909952004683 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 909952004684 Walker A/P-loop; other site 909952004685 ATP binding site [chemical binding]; other site 909952004686 Q-loop/lid; other site 909952004687 ABC transporter signature motif; other site 909952004688 Walker B; other site 909952004689 D-loop; other site 909952004690 H-loop/switch region; other site 909952004691 ABC-2 type transporter; Region: ABC2_membrane; cl17235 909952004692 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 909952004693 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 909952004694 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 909952004695 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 909952004696 catalytic site [active] 909952004697 Asp-box motif; other site 909952004698 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 909952004699 UbiA prenyltransferase family; Region: UbiA; pfam01040 909952004700 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 909952004701 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 909952004702 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 909952004703 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 909952004704 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 909952004705 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 909952004706 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 909952004707 putative active site [active] 909952004708 DoxX; Region: DoxX; pfam07681 909952004709 Thioredoxin; Region: Thioredoxin_4; cl17273 909952004710 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 909952004711 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208 909952004712 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 909952004713 active site 909952004714 HIGH motif; other site 909952004715 nucleotide binding site [chemical binding]; other site 909952004716 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 909952004717 active site 909952004718 KMSKS motif; other site 909952004719 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 909952004720 tRNA binding surface [nucleotide binding]; other site 909952004721 anticodon binding site; other site 909952004722 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 909952004723 Endo-alpha-N-acetylgalactosaminidase; Region: Glyco_hydro_101; pfam12905 909952004724 Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown]; Region: COG4946 909952004725 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 909952004726 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 909952004727 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 909952004728 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 909952004729 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 909952004730 protein binding site [polypeptide binding]; other site 909952004731 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 909952004732 Domain interface; other site 909952004733 Peptide binding site; other site 909952004734 Active site tetrad [active] 909952004735 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 909952004736 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 909952004737 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 909952004738 Walker A motif; other site 909952004739 ATP binding site [chemical binding]; other site 909952004740 Walker B motif; other site 909952004741 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 909952004742 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 909952004743 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 909952004744 oligomer interface [polypeptide binding]; other site 909952004745 active site residues [active] 909952004746 Clp protease; Region: CLP_protease; pfam00574 909952004747 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 909952004748 oligomer interface [polypeptide binding]; other site 909952004749 active site residues [active] 909952004750 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 909952004751 Domain of unknown function DUF20; Region: UPF0118; pfam01594 909952004752 trigger factor; Provisional; Region: tig; PRK01490 909952004753 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 909952004754 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 909952004755 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 909952004756 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 909952004757 ATP binding site [chemical binding]; other site 909952004758 putative Mg++ binding site [ion binding]; other site 909952004759 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 909952004760 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 909952004761 nucleotide binding region [chemical binding]; other site 909952004762 ATP-binding site [chemical binding]; other site 909952004763 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 909952004764 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 909952004765 ATP binding site [chemical binding]; other site 909952004766 putative Mg++ binding site [ion binding]; other site 909952004767 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 909952004768 ATP-binding site [chemical binding]; other site 909952004769 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 909952004770 Part of AAA domain; Region: AAA_19; pfam13245 909952004771 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 909952004772 Family description; Region: UvrD_C_2; pfam13538 909952004773 The HIRAN protein (HIP116, Rad5p N-terminal) is found in the N-terminal regions of the SWI2/SNF2 proteins typified by HIP116 and Rad5p; Region: HIRAN; smart00910 909952004774 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 909952004775 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 909952004776 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 909952004777 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 909952004778 dimer interface [polypeptide binding]; other site 909952004779 putative anticodon binding site; other site 909952004780 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 909952004781 motif 1; other site 909952004782 dimer interface [polypeptide binding]; other site 909952004783 active site 909952004784 motif 2; other site 909952004785 motif 3; other site 909952004786 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 909952004787 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 909952004788 putative DNA binding site [nucleotide binding]; other site 909952004789 catalytic residue [active] 909952004790 putative H2TH interface [polypeptide binding]; other site 909952004791 putative catalytic residues [active] 909952004792 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 909952004793 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 909952004794 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 909952004795 hypothetical protein; Provisional; Region: PRK01346 909952004796 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 909952004797 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 909952004798 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 909952004799 nucleotide binding pocket [chemical binding]; other site 909952004800 K-X-D-G motif; other site 909952004801 catalytic site [active] 909952004802 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 909952004803 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 909952004804 Helix-hairpin-helix motif; Region: HHH; pfam00633 909952004805 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 909952004806 Dimer interface [polypeptide binding]; other site 909952004807 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 909952004808 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 909952004809 Zn binding site [ion binding]; other site 909952004810 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 909952004811 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 909952004812 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 909952004813 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 909952004814 active site 909952004815 catalytic site [active] 909952004816 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 909952004817 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 909952004818 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 909952004819 active site 909952004820 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 909952004821 active site 909952004822 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 909952004823 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 909952004824 acyl-activating enzyme (AAE) consensus motif; other site 909952004825 putative AMP binding site [chemical binding]; other site 909952004826 putative active site [active] 909952004827 putative CoA binding site [chemical binding]; other site 909952004828 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 909952004829 MarR family; Region: MarR_2; pfam12802 909952004830 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 909952004831 FAD binding domain; Region: FAD_binding_4; pfam01565 909952004832 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 909952004833 Predicted transcriptional regulators [Transcription]; Region: COG1695 909952004834 Transcriptional regulator PadR-like family; Region: PadR; cl17335 909952004835 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 909952004836 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 909952004837 Walker A/P-loop; other site 909952004838 ATP binding site [chemical binding]; other site 909952004839 Q-loop/lid; other site 909952004840 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 909952004841 ABC transporter; Region: ABC_tran_2; pfam12848 909952004842 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 909952004843 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 909952004844 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 909952004845 dimer interface [polypeptide binding]; other site 909952004846 ssDNA binding site [nucleotide binding]; other site 909952004847 tetramer (dimer of dimers) interface [polypeptide binding]; other site 909952004848 YfjP GTPase; Region: YfjP; cd11383 909952004849 G1 box; other site 909952004850 GTP/Mg2+ binding site [chemical binding]; other site 909952004851 Switch I region; other site 909952004852 G2 box; other site 909952004853 Switch II region; other site 909952004854 G3 box; other site 909952004855 G4 box; other site 909952004856 G5 box; other site 909952004857 Dynamin family; Region: Dynamin_N; pfam00350 909952004858 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 909952004859 G1 box; other site 909952004860 GTP/Mg2+ binding site [chemical binding]; other site 909952004861 G2 box; other site 909952004862 Switch I region; other site 909952004863 Protease prsW family; Region: PrsW-protease; pfam13367 909952004864 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909952004865 putative substrate translocation pore; other site 909952004866 Major Facilitator Superfamily; Region: MFS_1; pfam07690 909952004867 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 909952004868 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 909952004869 catalytic site [active] 909952004870 putative active site [active] 909952004871 putative substrate binding site [chemical binding]; other site 909952004872 dimer interface [polypeptide binding]; other site 909952004873 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 909952004874 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 909952004875 Catalytic domain of Protein Kinases; Region: PKc; cd00180 909952004876 active site 909952004877 ATP binding site [chemical binding]; other site 909952004878 substrate binding site [chemical binding]; other site 909952004879 activation loop (A-loop); other site 909952004880 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 909952004881 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 909952004882 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 909952004883 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 909952004884 active site 909952004885 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 909952004886 generic binding surface I; other site 909952004887 generic binding surface II; other site 909952004888 DNA Polymerase Y-family; Region: PolY_like; cd03468 909952004889 active site 909952004890 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 909952004891 DNA binding site [nucleotide binding] 909952004892 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 909952004893 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 909952004894 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 909952004895 catalytic triad [active] 909952004896 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 909952004897 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 909952004898 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 909952004899 dimer interface [polypeptide binding]; other site 909952004900 conserved gate region; other site 909952004901 putative PBP binding loops; other site 909952004902 ABC-ATPase subunit interface; other site 909952004903 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 909952004904 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 909952004905 dimer interface [polypeptide binding]; other site 909952004906 conserved gate region; other site 909952004907 putative PBP binding loops; other site 909952004908 ABC-ATPase subunit interface; other site 909952004909 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 909952004910 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 909952004911 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 909952004912 catalytic triad [active] 909952004913 CH-type (Chalaropsis-type) lysozymes represent one of four functionally-defined classes of peptidoglycan hydrolases (also referred to as endo-N-acetylmuramidases) that cleave bacterial cell wall peptidoglycans. CH-type lysozymes exhibit both lysozyme; Region: GH25_CH-type; cd06412 909952004914 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 909952004915 active site 909952004916 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 909952004917 active site 909952004918 catalytic triad [active] 909952004919 oxyanion hole [active] 909952004920 Thrombospondin type 3 repeat; Region: TSP_3; pfam02412 909952004921 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 909952004922 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 909952004923 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 909952004924 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 909952004925 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 909952004926 putative active site [active] 909952004927 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 909952004928 DNA polymerase IV; Provisional; Region: PRK03348 909952004929 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 909952004930 active site 909952004931 DNA binding site [nucleotide binding] 909952004932 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 909952004933 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 909952004934 folate binding site [chemical binding]; other site 909952004935 NADP+ binding site [chemical binding]; other site 909952004936 thymidylate synthase; Reviewed; Region: thyA; PRK01827 909952004937 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 909952004938 dimerization interface [polypeptide binding]; other site 909952004939 active site 909952004940 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 909952004941 active site 909952004942 dimerization interface [polypeptide binding]; other site 909952004943 ribonuclease PH; Reviewed; Region: rph; PRK00173 909952004944 Ribonuclease PH; Region: RNase_PH_bact; cd11362 909952004945 hexamer interface [polypeptide binding]; other site 909952004946 active site 909952004947 glutamate racemase; Provisional; Region: PRK00865 909952004948 FeoA domain; Region: FeoA; pfam04023 909952004949 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 909952004950 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 909952004951 G1 box; other site 909952004952 GTP/Mg2+ binding site [chemical binding]; other site 909952004953 Switch I region; other site 909952004954 G2 box; other site 909952004955 G3 box; other site 909952004956 Switch II region; other site 909952004957 G4 box; other site 909952004958 G5 box; other site 909952004959 Nucleoside recognition; Region: Gate; pfam07670 909952004960 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 909952004961 Nucleoside recognition; Region: Gate; pfam07670 909952004962 NifU-like domain; Region: NifU; cl00484 909952004963 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 909952004964 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 909952004965 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 909952004966 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 909952004967 active site 909952004968 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 909952004969 IHF dimer interface [polypeptide binding]; other site 909952004970 IHF - DNA interface [nucleotide binding]; other site 909952004971 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 909952004972 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 909952004973 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 909952004974 RDD family; Region: RDD; pfam06271 909952004975 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 909952004976 Dehydroquinase class II; Region: DHquinase_II; pfam01220 909952004977 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 909952004978 trimer interface [polypeptide binding]; other site 909952004979 active site 909952004980 dimer interface [polypeptide binding]; other site 909952004981 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 909952004982 Cation efflux family; Region: Cation_efflux; pfam01545 909952004983 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 909952004984 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 909952004985 Trm112p-like protein; Region: Trm112p; cl01066 909952004986 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 909952004987 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 909952004988 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit [DNA replication, recombination, and repair]; Region: GyrA; COG0188 909952004989 Transcription factor WhiB; Region: Whib; pfam02467 909952004990 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 909952004991 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 909952004992 Substrate binding site; other site 909952004993 TIGR03089 family protein; Region: TIGR03089 909952004994 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 909952004995 ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525 909952004996 Ligand binding site; other site 909952004997 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 909952004998 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 909952004999 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 909952005000 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 909952005001 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 909952005002 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 909952005003 AIR carboxylase; Region: AIRC; pfam00731 909952005004 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 909952005005 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 909952005006 NAD binding site [chemical binding]; other site 909952005007 ATP-grasp domain; Region: ATP-grasp; pfam02222 909952005008 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 909952005009 active site pocket [active] 909952005010 oxyanion hole [active] 909952005011 catalytic triad [active] 909952005012 active site nucleophile [active] 909952005013 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 909952005014 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 909952005015 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 909952005016 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 909952005017 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 909952005018 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 909952005019 Maf-like protein; Region: Maf; pfam02545 909952005020 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 909952005021 active site 909952005022 dimer interface [polypeptide binding]; other site 909952005023 short chain dehydrogenase; Provisional; Region: PRK08219 909952005024 classical (c) SDRs; Region: SDR_c; cd05233 909952005025 NAD(P) binding site [chemical binding]; other site 909952005026 active site 909952005027 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 909952005028 dimer interface [polypeptide binding]; other site 909952005029 substrate binding site [chemical binding]; other site 909952005030 ATP binding site [chemical binding]; other site 909952005031 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 909952005032 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 909952005033 Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158 909952005034 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 909952005035 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 909952005036 oligomer interface [polypeptide binding]; other site 909952005037 metal binding site [ion binding]; metal-binding site 909952005038 metal binding site [ion binding]; metal-binding site 909952005039 putative Cl binding site [ion binding]; other site 909952005040 aspartate ring; other site 909952005041 basic sphincter; other site 909952005042 hydrophobic gate; other site 909952005043 periplasmic entrance; other site 909952005044 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 909952005045 nudix motif; other site 909952005046 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 909952005047 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 909952005048 ATP-grasp domain; Region: ATP-grasp_4; cl17255 909952005049 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 909952005050 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 909952005051 carboxyltransferase (CT) interaction site; other site 909952005052 biotinylation site [posttranslational modification]; other site 909952005053 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 909952005054 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 909952005055 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 909952005056 purine nucleoside phosphorylase; Provisional; Region: PRK08202 909952005057 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 909952005058 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 909952005059 active site 909952005060 substrate binding site [chemical binding]; other site 909952005061 metal binding site [ion binding]; metal-binding site 909952005062 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 909952005063 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 909952005064 acyl-activating enzyme (AAE) consensus motif; other site 909952005065 AMP binding site [chemical binding]; other site 909952005066 active site 909952005067 CoA binding site [chemical binding]; other site 909952005068 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 909952005069 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909952005070 putative substrate translocation pore; other site 909952005071 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 909952005072 active site 909952005073 catalytic site [active] 909952005074 substrate binding site [chemical binding]; other site 909952005075 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 909952005076 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 909952005077 active site 909952005078 HIGH motif; other site 909952005079 KMSKS motif; other site 909952005080 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 909952005081 tRNA binding surface [nucleotide binding]; other site 909952005082 anticodon binding site; other site 909952005083 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 909952005084 RNA/DNA hybrid binding site [nucleotide binding]; other site 909952005085 active site 909952005086 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 909952005087 active site 909952005088 catalytic motif [active] 909952005089 Zn binding site [ion binding]; other site 909952005090 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 909952005091 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 909952005092 TM-ABC transporter signature motif; other site 909952005093 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 909952005094 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 909952005095 TM-ABC transporter signature motif; other site 909952005096 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 909952005097 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 909952005098 Walker A/P-loop; other site 909952005099 ATP binding site [chemical binding]; other site 909952005100 Q-loop/lid; other site 909952005101 ABC transporter signature motif; other site 909952005102 Walker B; other site 909952005103 D-loop; other site 909952005104 H-loop/switch region; other site 909952005105 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 909952005106 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 909952005107 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 909952005108 ligand binding site [chemical binding]; other site 909952005109 Phosphotransferase enzyme family; Region: APH; pfam01636 909952005110 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 909952005111 Domain of unknown function DUF21; Region: DUF21; pfam01595 909952005112 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 909952005113 Transporter associated domain; Region: CorC_HlyC; smart01091 909952005114 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 909952005115 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 909952005116 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 909952005117 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 909952005118 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 909952005119 active site 909952005120 substrate binding site [chemical binding]; other site 909952005121 cosubstrate binding site; other site 909952005122 catalytic site [active] 909952005123 malate dehydrogenase; Provisional; Region: PRK05442 909952005124 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 909952005125 NAD(P) binding site [chemical binding]; other site 909952005126 dimer interface [polypeptide binding]; other site 909952005127 malate binding site [chemical binding]; other site 909952005128 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 909952005129 putative catalytic cysteine [active] 909952005130 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 909952005131 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 909952005132 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 909952005133 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 909952005134 homodimer interface [polypeptide binding]; other site 909952005135 NADP binding site [chemical binding]; other site 909952005136 substrate binding site [chemical binding]; other site 909952005137 Phosphoesterase family; Region: Phosphoesterase; pfam04185 909952005138 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 909952005139 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 909952005140 purine monophosphate binding site [chemical binding]; other site 909952005141 dimer interface [polypeptide binding]; other site 909952005142 putative catalytic residues [active] 909952005143 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 909952005144 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 909952005145 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 909952005146 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 909952005147 active site 909952005148 cosubstrate binding site; other site 909952005149 substrate binding site [chemical binding]; other site 909952005150 catalytic site [active] 909952005151 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 909952005152 homopentamer interface [polypeptide binding]; other site 909952005153 active site 909952005154 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 909952005155 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 909952005156 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 909952005157 dimerization interface [polypeptide binding]; other site 909952005158 active site 909952005159 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 909952005160 Lumazine binding domain; Region: Lum_binding; pfam00677 909952005161 Lumazine binding domain; Region: Lum_binding; pfam00677 909952005162 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 909952005163 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 909952005164 catalytic motif [active] 909952005165 Zn binding site [ion binding]; other site 909952005166 RibD C-terminal domain; Region: RibD_C; cl17279 909952005167 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 909952005168 CoA binding domain; Region: CoA_binding; smart00881 909952005169 CoA-ligase; Region: Ligase_CoA; pfam00549 909952005170 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 909952005171 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 909952005172 CoA-ligase; Region: Ligase_CoA; pfam00549 909952005173 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 909952005174 Part of AAA domain; Region: AAA_19; pfam13245 909952005175 Family description; Region: UvrD_C_2; pfam13538 909952005176 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 909952005177 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 909952005178 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 909952005179 Walker A/P-loop; other site 909952005180 ATP binding site [chemical binding]; other site 909952005181 Q-loop/lid; other site 909952005182 ABC transporter signature motif; other site 909952005183 Walker B; other site 909952005184 D-loop; other site 909952005185 H-loop/switch region; other site 909952005186 NIL domain; Region: NIL; pfam09383 909952005187 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 909952005188 ABC-ATPase subunit interface; other site 909952005189 PspC domain; Region: PspC; pfam04024 909952005190 GMP synthase; Reviewed; Region: guaA; PRK00074 909952005191 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 909952005192 AMP/PPi binding site [chemical binding]; other site 909952005193 candidate oxyanion hole; other site 909952005194 catalytic triad [active] 909952005195 potential glutamine specificity residues [chemical binding]; other site 909952005196 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 909952005197 ATP Binding subdomain [chemical binding]; other site 909952005198 Ligand Binding sites [chemical binding]; other site 909952005199 Dimerization subdomain; other site 909952005200 serine O-acetyltransferase; Region: cysE; TIGR01172 909952005201 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 909952005202 trimer interface [polypeptide binding]; other site 909952005203 active site 909952005204 substrate binding site [chemical binding]; other site 909952005205 CoA binding site [chemical binding]; other site 909952005206 chorismate mutase; Provisional; Region: PRK09239 909952005207 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 909952005208 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 909952005209 phosphate binding site [ion binding]; other site 909952005210 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 909952005211 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 909952005212 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 909952005213 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 909952005214 active site 909952005215 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 909952005216 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 909952005217 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 909952005218 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 909952005219 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 909952005220 ring oligomerisation interface [polypeptide binding]; other site 909952005221 ATP/Mg binding site [chemical binding]; other site 909952005222 stacking interactions; other site 909952005223 hinge regions; other site 909952005224 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 909952005225 oligomerisation interface [polypeptide binding]; other site 909952005226 mobile loop; other site 909952005227 roof hairpin; other site 909952005228 Methyltransferase domain; Region: Methyltransf_26; pfam13659 909952005229 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 909952005230 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 909952005231 Walker A/P-loop; other site 909952005232 ATP binding site [chemical binding]; other site 909952005233 Q-loop/lid; other site 909952005234 ABC transporter signature motif; other site 909952005235 Walker B; other site 909952005236 D-loop; other site 909952005237 H-loop/switch region; other site 909952005238 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 909952005239 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 909952005240 ABC-ATPase subunit interface; other site 909952005241 dimer interface [polypeptide binding]; other site 909952005242 putative PBP binding regions; other site 909952005243 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 909952005244 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 909952005245 intersubunit interface [polypeptide binding]; other site 909952005246 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 909952005247 putative active site [active] 909952005248 nucleotide binding site [chemical binding]; other site 909952005249 nudix motif; other site 909952005250 putative metal binding site [ion binding]; other site 909952005251 UGMP family protein; Validated; Region: PRK09604 909952005252 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 909952005253 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 909952005254 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 909952005255 Coenzyme A binding pocket [chemical binding]; other site 909952005256 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 909952005257 Glycoprotease family; Region: Peptidase_M22; pfam00814 909952005258 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 909952005259 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 909952005260 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 909952005261 DEAD-like helicases superfamily; Region: DEXDc; smart00487 909952005262 ATP binding site [chemical binding]; other site 909952005263 Mg++ binding site [ion binding]; other site 909952005264 motif III; other site 909952005265 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 909952005266 nucleotide binding region [chemical binding]; other site 909952005267 ATP-binding site [chemical binding]; other site 909952005268 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 909952005269 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 909952005270 Walker A/P-loop; other site 909952005271 ATP binding site [chemical binding]; other site 909952005272 Q-loop/lid; other site 909952005273 ABC transporter signature motif; other site 909952005274 Walker B; other site 909952005275 D-loop; other site 909952005276 H-loop/switch region; other site 909952005277 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 909952005278 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 909952005279 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 909952005280 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 909952005281 putative substrate binding site [chemical binding]; other site 909952005282 putative ATP binding site [chemical binding]; other site 909952005283 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 909952005284 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 909952005285 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 909952005286 glutaminase active site [active] 909952005287 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 909952005288 dimer interface [polypeptide binding]; other site 909952005289 active site 909952005290 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 909952005291 dimer interface [polypeptide binding]; other site 909952005292 active site 909952005293 Lipase (class 2); Region: Lipase_2; pfam01674 909952005294 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 909952005295 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 909952005296 Lipase (class 2); Region: Lipase_2; pfam01674 909952005297 pantothenate kinase; Provisional; Region: PRK05439 909952005298 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 909952005299 ATP-binding site [chemical binding]; other site 909952005300 CoA-binding site [chemical binding]; other site 909952005301 Mg2+-binding site [ion binding]; other site 909952005302 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 909952005303 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 909952005304 active site 909952005305 substrate binding site [chemical binding]; other site 909952005306 metal binding site [ion binding]; metal-binding site 909952005307 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 909952005308 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 909952005309 23S rRNA interface [nucleotide binding]; other site 909952005310 L3 interface [polypeptide binding]; other site 909952005311 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 909952005312 S-adenosylmethionine binding site [chemical binding]; other site 909952005313 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 909952005314 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 909952005315 dimerization interface 3.5A [polypeptide binding]; other site 909952005316 active site 909952005317 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 909952005318 S-adenosylmethionine binding site [chemical binding]; other site 909952005319 Cobalt transport protein; Region: CbiQ; cl00463 909952005320 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 909952005321 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 909952005322 Walker A/P-loop; other site 909952005323 ATP binding site [chemical binding]; other site 909952005324 Q-loop/lid; other site 909952005325 ABC transporter signature motif; other site 909952005326 Walker B; other site 909952005327 D-loop; other site 909952005328 H-loop/switch region; other site 909952005329 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 909952005330 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 909952005331 Walker A/P-loop; other site 909952005332 ATP binding site [chemical binding]; other site 909952005333 Q-loop/lid; other site 909952005334 ABC transporter signature motif; other site 909952005335 Walker B; other site 909952005336 D-loop; other site 909952005337 H-loop/switch region; other site 909952005338 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 909952005339 classical (c) SDRs; Region: SDR_c; cd05233 909952005340 NAD(P) binding site [chemical binding]; other site 909952005341 active site 909952005342 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 909952005343 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 909952005344 Walker A/P-loop; other site 909952005345 ATP binding site [chemical binding]; other site 909952005346 Q-loop/lid; other site 909952005347 ABC transporter signature motif; other site 909952005348 Walker B; other site 909952005349 D-loop; other site 909952005350 H-loop/switch region; other site 909952005351 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 909952005352 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 909952005353 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 909952005354 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 909952005355 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909952005356 Major Facilitator Superfamily; Region: MFS_1; pfam07690 909952005357 putative substrate translocation pore; other site 909952005358 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 909952005359 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 909952005360 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 909952005361 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 909952005362 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 909952005363 alphaNTD homodimer interface [polypeptide binding]; other site 909952005364 alphaNTD - beta interaction site [polypeptide binding]; other site 909952005365 alphaNTD - beta' interaction site [polypeptide binding]; other site 909952005366 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 909952005367 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 909952005368 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 909952005369 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 909952005370 RNA binding surface [nucleotide binding]; other site 909952005371 30S ribosomal protein S11; Validated; Region: PRK05309 909952005372 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 909952005373 30S ribosomal protein S13; Region: bact_S13; TIGR03631 909952005374 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 909952005375 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 909952005376 rRNA binding site [nucleotide binding]; other site 909952005377 predicted 30S ribosome binding site; other site 909952005378 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 909952005379 active site 909952005380 adenylate kinase; Reviewed; Region: adk; PRK00279 909952005381 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 909952005382 AMP-binding site [chemical binding]; other site 909952005383 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 909952005384 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 909952005385 SecY translocase; Region: SecY; pfam00344 909952005386 Major Facilitator Superfamily; Region: MFS_1; pfam07690 909952005387 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909952005388 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 909952005389 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 909952005390 putative active site [active] 909952005391 catalytic site [active] 909952005392 putative metal binding site [ion binding]; other site 909952005393 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 909952005394 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 909952005395 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 909952005396 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 909952005397 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 909952005398 23S rRNA binding site [nucleotide binding]; other site 909952005399 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 909952005400 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 909952005401 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 909952005402 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 909952005403 23S rRNA interface [nucleotide binding]; other site 909952005404 5S rRNA interface [nucleotide binding]; other site 909952005405 L27 interface [polypeptide binding]; other site 909952005406 L5 interface [polypeptide binding]; other site 909952005407 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 909952005408 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 909952005409 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 909952005410 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 909952005411 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 909952005412 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 909952005413 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 909952005414 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 909952005415 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 909952005416 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 909952005417 RNA binding site [nucleotide binding]; other site 909952005418 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 909952005419 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 909952005420 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 909952005421 23S rRNA interface [nucleotide binding]; other site 909952005422 putative translocon interaction site; other site 909952005423 signal recognition particle (SRP54) interaction site; other site 909952005424 L23 interface [polypeptide binding]; other site 909952005425 trigger factor interaction site; other site 909952005426 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 909952005427 23S rRNA interface [nucleotide binding]; other site 909952005428 5S rRNA interface [nucleotide binding]; other site 909952005429 putative antibiotic binding site [chemical binding]; other site 909952005430 L25 interface [polypeptide binding]; other site 909952005431 L27 interface [polypeptide binding]; other site 909952005432 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 909952005433 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 909952005434 G-X-X-G motif; other site 909952005435 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 909952005436 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 909952005437 putative translocon binding site; other site 909952005438 protein-rRNA interface [nucleotide binding]; other site 909952005439 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 909952005440 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 909952005441 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 909952005442 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 909952005443 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 909952005444 50S ribosomal protein L4; Provisional; Region: rplD; PRK14547 909952005445 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 909952005446 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 909952005447 6-carboxyhexanoate--CoA ligase; Region: BioW; pfam03744 909952005448 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 909952005449 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 909952005450 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 909952005451 catalytic residue [active] 909952005452 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 909952005453 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 909952005454 HIGH motif; other site 909952005455 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 909952005456 active site 909952005457 KMSKS motif; other site 909952005458 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 909952005459 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 909952005460 active site 909952005461 HIGH motif; other site 909952005462 nucleotide binding site [chemical binding]; other site 909952005463 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 909952005464 active site 909952005465 KMSKS motif; other site 909952005466 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 909952005467 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 909952005468 elongation factor Tu; Reviewed; Region: PRK00049 909952005469 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 909952005470 G1 box; other site 909952005471 GEF interaction site [polypeptide binding]; other site 909952005472 GTP/Mg2+ binding site [chemical binding]; other site 909952005473 Switch I region; other site 909952005474 G2 box; other site 909952005475 G3 box; other site 909952005476 Switch II region; other site 909952005477 G4 box; other site 909952005478 G5 box; other site 909952005479 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 909952005480 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 909952005481 Antibiotic Binding Site [chemical binding]; other site 909952005482 elongation factor G; Reviewed; Region: PRK00007 909952005483 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 909952005484 G1 box; other site 909952005485 putative GEF interaction site [polypeptide binding]; other site 909952005486 GTP/Mg2+ binding site [chemical binding]; other site 909952005487 Switch I region; other site 909952005488 G2 box; other site 909952005489 G3 box; other site 909952005490 Switch II region; other site 909952005491 G4 box; other site 909952005492 G5 box; other site 909952005493 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 909952005494 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 909952005495 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 909952005496 30S ribosomal protein S7; Validated; Region: PRK05302 909952005497 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 909952005498 S17 interaction site [polypeptide binding]; other site 909952005499 S8 interaction site; other site 909952005500 16S rRNA interaction site [nucleotide binding]; other site 909952005501 streptomycin interaction site [chemical binding]; other site 909952005502 23S rRNA interaction site [nucleotide binding]; other site 909952005503 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 909952005504 Filamin/ABP280 repeat; Region: Filamin; pfam00630 909952005505 putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773 909952005506 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 909952005507 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 909952005508 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 909952005509 DNA-directed RNA polymerase, beta' subunit, predominant form; Region: rpoC_TIGR; TIGR02386 909952005510 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 909952005511 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 909952005512 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 909952005513 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 909952005514 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 909952005515 G-loop; other site 909952005516 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 909952005517 DNA binding site [nucleotide binding] 909952005518 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 909952005519 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 909952005520 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 909952005521 RPB12 interaction site [polypeptide binding]; other site 909952005522 RPB1 interaction site [polypeptide binding]; other site 909952005523 RPB10 interaction site [polypeptide binding]; other site 909952005524 RPB11 interaction site [polypeptide binding]; other site 909952005525 RPB3 interaction site [polypeptide binding]; other site 909952005526 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 909952005527 core dimer interface [polypeptide binding]; other site 909952005528 peripheral dimer interface [polypeptide binding]; other site 909952005529 L10 interface [polypeptide binding]; other site 909952005530 L11 interface [polypeptide binding]; other site 909952005531 putative EF-Tu interaction site [polypeptide binding]; other site 909952005532 putative EF-G interaction site [polypeptide binding]; other site 909952005533 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 909952005534 23S rRNA interface [nucleotide binding]; other site 909952005535 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 909952005536 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 909952005537 mRNA/rRNA interface [nucleotide binding]; other site 909952005538 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 909952005539 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 909952005540 23S rRNA interface [nucleotide binding]; other site 909952005541 putative thiostrepton binding site; other site 909952005542 L7/L12 interface [polypeptide binding]; other site 909952005543 L25 interface [polypeptide binding]; other site 909952005544 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 909952005545 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 909952005546 putative homodimer interface [polypeptide binding]; other site 909952005547 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 909952005548 heterodimer interface [polypeptide binding]; other site 909952005549 homodimer interface [polypeptide binding]; other site 909952005550 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 909952005551 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 909952005552 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 909952005553 pyridoxal 5'-phosphate binding site [chemical binding]; other site 909952005554 homodimer interface [polypeptide binding]; other site 909952005555 catalytic residue [active] 909952005556 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 909952005557 FAD binding domain; Region: FAD_binding_4; pfam01565 909952005558 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 909952005559 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 909952005560 active site 909952005561 catalytic site [active] 909952005562 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 909952005563 active site 909952005564 catalytic site [active] 909952005565 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 909952005566 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 909952005567 putative active site [active] 909952005568 putative catalytic site [active] 909952005569 putative DNA binding site [nucleotide binding]; other site 909952005570 putative phosphate binding site [ion binding]; other site 909952005571 metal binding site A [ion binding]; metal-binding site 909952005572 putative AP binding site [nucleotide binding]; other site 909952005573 putative metal binding site B [ion binding]; other site 909952005574 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 909952005575 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 909952005576 substrate binding site [chemical binding]; other site 909952005577 oxyanion hole (OAH) forming residues; other site 909952005578 trimer interface [polypeptide binding]; other site 909952005579 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 909952005580 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 909952005581 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 909952005582 4Fe-4S binding domain; Region: Fer4; cl02805 909952005583 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329 909952005584 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194 909952005585 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 909952005586 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 909952005587 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 909952005588 dimer interface [polypeptide binding]; other site 909952005589 PYR/PP interface [polypeptide binding]; other site 909952005590 TPP binding site [chemical binding]; other site 909952005591 substrate binding site [chemical binding]; other site 909952005592 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 909952005593 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 909952005594 TPP-binding site [chemical binding]; other site 909952005595 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 909952005596 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 909952005597 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 909952005598 active site 909952005599 catalytic triad [active] 909952005600 oxyanion hole [active] 909952005601 Thrombospondin type 3 repeat; Region: TSP_3; pfam02412 909952005602 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 909952005603 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 909952005604 active site 909952005605 Zn binding site [ion binding]; other site 909952005606 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 909952005607 heme ABC exporter, ATP-binding protein CcmA; Region: ccmA; TIGR01189 909952005608 Walker A/P-loop; other site 909952005609 ATP binding site [chemical binding]; other site 909952005610 Q-loop/lid; other site 909952005611 ABC transporter signature motif; other site 909952005612 Walker B; other site 909952005613 D-loop; other site 909952005614 H-loop/switch region; other site 909952005615 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 909952005616 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 909952005617 Walker A/P-loop; other site 909952005618 ATP binding site [chemical binding]; other site 909952005619 Q-loop/lid; other site 909952005620 ABC transporter signature motif; other site 909952005621 Walker B; other site 909952005622 D-loop; other site 909952005623 H-loop/switch region; other site 909952005624 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 909952005625 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 909952005626 active site 909952005627 SAM binding site [chemical binding]; other site 909952005628 homodimer interface [polypeptide binding]; other site 909952005629 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 909952005630 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 909952005631 substrate binding pocket [chemical binding]; other site 909952005632 chain length determination region; other site 909952005633 substrate-Mg2+ binding site; other site 909952005634 catalytic residues [active] 909952005635 aspartate-rich region 1; other site 909952005636 active site lid residues [active] 909952005637 aspartate-rich region 2; other site 909952005638 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 909952005639 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 909952005640 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 909952005641 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 909952005642 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 909952005643 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 909952005644 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 909952005645 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 909952005646 NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839 909952005647 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 909952005648 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 909952005649 4Fe-4S binding domain; Region: Fer4; pfam00037 909952005650 4Fe-4S binding domain; Region: Fer4; pfam00037 909952005651 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 909952005652 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 909952005653 NADH dehydrogenase subunit G; Validated; Region: PRK07860 909952005654 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 909952005655 catalytic loop [active] 909952005656 iron binding site [ion binding]; other site 909952005657 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 909952005658 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 909952005659 [4Fe-4S] binding site [ion binding]; other site 909952005660 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 909952005661 molybdopterin cofactor binding site; other site 909952005662 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 909952005663 SLBB domain; Region: SLBB; pfam10531 909952005664 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 909952005665 NADH dehydrogenase subunit E; Validated; Region: PRK07539 909952005666 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 909952005667 putative dimer interface [polypeptide binding]; other site 909952005668 [2Fe-2S] cluster binding site [ion binding]; other site 909952005669 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 909952005670 NADH dehydrogenase subunit D; Validated; Region: PRK06075 909952005671 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 909952005672 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 909952005673 NADH dehydrogenase subunit B; Validated; Region: PRK06411 909952005674 NADH dehydrogenase subunit A; Validated; Region: PRK07928 909952005675 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 909952005676 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 909952005677 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 909952005678 ABC transporter; Region: ABC_tran; pfam00005 909952005679 Q-loop/lid; other site 909952005680 ABC transporter signature motif; other site 909952005681 Walker B; other site 909952005682 D-loop; other site 909952005683 H-loop/switch region; other site 909952005684 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 909952005685 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 909952005686 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 909952005687 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 909952005688 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 909952005689 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 909952005690 Walker A/P-loop; other site 909952005691 ATP binding site [chemical binding]; other site 909952005692 Q-loop/lid; other site 909952005693 ABC transporter signature motif; other site 909952005694 Walker B; other site 909952005695 D-loop; other site 909952005696 H-loop/switch region; other site 909952005697 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 909952005698 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 909952005699 Walker A/P-loop; other site 909952005700 ATP binding site [chemical binding]; other site 909952005701 Q-loop/lid; other site 909952005702 ABC transporter signature motif; other site 909952005703 Walker B; other site 909952005704 D-loop; other site 909952005705 H-loop/switch region; other site 909952005706 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 909952005707 UbiA prenyltransferase family; Region: UbiA; pfam01040 909952005708 H+ Antiporter protein; Region: 2A0121; TIGR00900 909952005709 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909952005710 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909952005711 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 909952005712 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 909952005713 DAK2 domain; Region: Dak2; cl03685 909952005714 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 909952005715 active pocket/dimerization site; other site 909952005716 active site 909952005717 phosphorylation site [posttranslational modification] 909952005718 Deoxycytidylate deaminase [Nucleotide transport and metabolism]; Region: ComEB; COG2131 909952005719 active site 909952005720 Zn binding site [ion binding]; other site 909952005721 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 909952005722 Cation efflux family; Region: Cation_efflux; cl00316 909952005723 A subgroup of L-lactate dehydrogenases; Region: LDH_3; cd05290 909952005724 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 909952005725 NAD binding site [chemical binding]; other site 909952005726 dimer interface [polypeptide binding]; other site 909952005727 tetramer (dimer of dimers) interface [polypeptide binding]; other site 909952005728 substrate binding site [chemical binding]; other site 909952005729 Patatin-like phospholipase; Region: Patatin; pfam01734 909952005730 active site 909952005731 nucleophile elbow; other site 909952005732 Patatin-like phospholipase; Region: Patatin; pfam01734 909952005733 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 909952005734 UMP phosphatase; Provisional; Region: PRK10444 909952005735 active site 909952005736 motif I; other site 909952005737 motif II; other site 909952005738 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 909952005739 Right handed beta helix region; Region: Beta_helix; pfam13229 909952005740 Right handed beta helix region; Region: Beta_helix; pfam13229 909952005741 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 909952005742 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 909952005743 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 909952005744 Domain of unknown function (DUF4091); Region: DUF4091; pfam13320 909952005745 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 909952005746 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 909952005747 dimer interface [polypeptide binding]; other site 909952005748 conserved gate region; other site 909952005749 putative PBP binding loops; other site 909952005750 ABC-ATPase subunit interface; other site 909952005751 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 909952005752 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 909952005753 Bacterial SH3 domain; Region: SH3_3; pfam08239 909952005754 Bacterial SH3 domain; Region: SH3_3; cl17532 909952005755 Bacterial SH3 domain; Region: SH3_3; cl17532 909952005756 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 909952005757 NlpC/P60 family; Region: NLPC_P60; cl17555 909952005758 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 909952005759 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 909952005760 dimer interface [polypeptide binding]; other site 909952005761 conserved gate region; other site 909952005762 putative PBP binding loops; other site 909952005763 ABC-ATPase subunit interface; other site 909952005764 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 909952005765 dimer interface [polypeptide binding]; other site 909952005766 conserved gate region; other site 909952005767 putative PBP binding loops; other site 909952005768 ABC-ATPase subunit interface; other site 909952005769 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 909952005770 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 909952005771 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 909952005772 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 909952005773 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 909952005774 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 909952005775 dimerization interface [polypeptide binding]; other site 909952005776 putative ATP binding site [chemical binding]; other site 909952005777 amidophosphoribosyltransferase; Provisional; Region: PRK07847 909952005778 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 909952005779 active site 909952005780 tetramer interface [polypeptide binding]; other site 909952005781 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 909952005782 active site 909952005783 hypothetical protein; Provisional; Region: PRK07907 909952005784 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 909952005785 active site 909952005786 metal binding site [ion binding]; metal-binding site 909952005787 dimer interface [polypeptide binding]; other site 909952005788 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 909952005789 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 909952005790 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 909952005791 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 909952005792 Glutamine amidotransferase class-I; Region: GATase; pfam00117 909952005793 glutamine binding [chemical binding]; other site 909952005794 catalytic triad [active] 909952005795 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 909952005796 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 909952005797 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 909952005798 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 909952005799 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 909952005800 dimerization interface [polypeptide binding]; other site 909952005801 ATP binding site [chemical binding]; other site 909952005802 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 909952005803 dimerization interface [polypeptide binding]; other site 909952005804 ATP binding site [chemical binding]; other site 909952005805 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909952005806 Major Facilitator Superfamily; Region: MFS_1; pfam07690 909952005807 putative substrate translocation pore; other site 909952005808 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 909952005809 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 909952005810 Zn binding site [ion binding]; other site 909952005811 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; cl02325 909952005812 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 909952005813 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 909952005814 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 909952005815 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 909952005816 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 909952005817 active site 909952005818 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 909952005819 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 909952005820 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 909952005821 active site 909952005822 catalytic triad [active] 909952005823 oxyanion hole [active] 909952005824 Thrombospondin type 3 repeat; Region: TSP_3; pfam02412 909952005825 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 909952005826 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 909952005827 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 909952005828 putative active site [active] 909952005829 catalytic triad [active] 909952005830 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 909952005831 ATP binding site [chemical binding]; other site 909952005832 active site 909952005833 substrate binding site [chemical binding]; other site 909952005834 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 909952005835 peroxiredoxin; Region: AhpC; TIGR03137 909952005836 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 909952005837 dimer interface [polypeptide binding]; other site 909952005838 decamer (pentamer of dimers) interface [polypeptide binding]; other site 909952005839 catalytic triad [active] 909952005840 peroxidatic and resolving cysteines [active] 909952005841 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 909952005842 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 909952005843 catalytic residue [active] 909952005844 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 909952005845 catalytic residues [active] 909952005846 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 909952005847 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 909952005848 Transcriptional regulator [Transcription]; Region: LysR; COG0583 909952005849 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 909952005850 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 909952005851 dimerization interface [polypeptide binding]; other site 909952005852 adenylosuccinate lyase; Region: purB; TIGR00928 909952005853 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 909952005854 tetramer interface [polypeptide binding]; other site 909952005855 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 909952005856 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 909952005857 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 909952005858 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 909952005859 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 909952005860 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 909952005861 GDP-binding site [chemical binding]; other site 909952005862 ACT binding site; other site 909952005863 IMP binding site; other site 909952005864 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 909952005865 Coenzyme A binding pocket [chemical binding]; other site 909952005866 Transcriptional regulators [Transcription]; Region: FadR; COG2186 909952005867 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 909952005868 DNA-binding site [nucleotide binding]; DNA binding site 909952005869 FCD domain; Region: FCD; pfam07729 909952005870 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 909952005871 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 909952005872 putative active site cavity [active] 909952005873 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 909952005874 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 909952005875 inhibitor site; inhibition site 909952005876 active site 909952005877 dimer interface [polypeptide binding]; other site 909952005878 catalytic residue [active] 909952005879 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 909952005880 putative sialic acid transporter; Provisional; Region: PRK03893 909952005881 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909952005882 putative substrate translocation pore; other site 909952005883 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909952005884 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 909952005885 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 909952005886 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 909952005887 G1 box; other site 909952005888 putative GEF interaction site [polypeptide binding]; other site 909952005889 GTP/Mg2+ binding site [chemical binding]; other site 909952005890 Switch I region; other site 909952005891 G2 box; other site 909952005892 G3 box; other site 909952005893 Switch II region; other site 909952005894 G4 box; other site 909952005895 G5 box; other site 909952005896 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 909952005897 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 909952005898 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 909952005899 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 909952005900 carboxyltransferase (CT) interaction site; other site 909952005901 biotinylation site [posttranslational modification]; other site 909952005902 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 909952005903 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 909952005904 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 909952005905 oxaloacetate decarboxylase; Provisional; Region: PRK12330 909952005906 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 909952005907 active site 909952005908 catalytic residues [active] 909952005909 metal binding site [ion binding]; metal-binding site 909952005910 homodimer binding site [polypeptide binding]; other site 909952005911 PAS domain; Region: PAS_9; pfam13426 909952005912 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 909952005913 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 909952005914 active site 909952005915 intersubunit interface [polypeptide binding]; other site 909952005916 zinc binding site [ion binding]; other site 909952005917 Na+ binding site [ion binding]; other site 909952005918 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 909952005919 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 909952005920 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 909952005921 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 909952005922 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 909952005923 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 909952005924 SEC-C motif; Region: SEC-C; pfam02810 909952005925 hypothetical protein; Provisional; Region: PRK04233 909952005926 benzoate transport; Region: 2A0115; TIGR00895 909952005927 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909952005928 putative substrate translocation pore; other site 909952005929 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909952005930 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 909952005931 Clp amino terminal domain; Region: Clp_N; pfam02861 909952005932 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 909952005933 Walker A motif; other site 909952005934 ATP binding site [chemical binding]; other site 909952005935 Walker B motif; other site 909952005936 arginine finger; other site 909952005937 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 909952005938 Walker A motif; other site 909952005939 ATP binding site [chemical binding]; other site 909952005940 Walker B motif; other site 909952005941 arginine finger; other site 909952005942 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 909952005943 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 909952005944 Eukaryotic phosphomannomutase; Region: PMM; cl17107 909952005945 fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377 909952005946 catalytic residue [active] 909952005947 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 909952005948 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 909952005949 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 909952005950 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 909952005951 Histidine kinase; Region: HisKA_3; pfam07730 909952005952 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 909952005953 ATP binding site [chemical binding]; other site 909952005954 Mg2+ binding site [ion binding]; other site 909952005955 G-X-G motif; other site 909952005956 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 909952005957 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 909952005958 active site 909952005959 phosphorylation site [posttranslational modification] 909952005960 intermolecular recognition site; other site 909952005961 dimerization interface [polypeptide binding]; other site 909952005962 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 909952005963 DNA binding residues [nucleotide binding] 909952005964 dimerization interface [polypeptide binding]; other site 909952005965 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 909952005966 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 909952005967 Walker A/P-loop; other site 909952005968 ATP binding site [chemical binding]; other site 909952005969 Q-loop/lid; other site 909952005970 ABC transporter signature motif; other site 909952005971 Walker B; other site 909952005972 D-loop; other site 909952005973 H-loop/switch region; other site 909952005974 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 909952005975 FtsX-like permease family; Region: FtsX; pfam02687 909952005976 FtsX-like permease family; Region: FtsX; pfam02687 909952005977 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 909952005978 nudix motif; other site 909952005979 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 909952005980 Predicted permease [General function prediction only]; Region: COG2985 909952005981 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 909952005982 TrkA-C domain; Region: TrkA_C; pfam02080 909952005983 TrkA-C domain; Region: TrkA_C; pfam02080 909952005984 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 909952005985 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 909952005986 6-hydroxycyclohex-1-ene-1-carboxyl-CoA dehydrogenase, N-benzyl-3-pyrrolidinol dehydrogenase, and other MDR family members; Region: hydroxyacyl_CoA_DH; cd08254 909952005987 putative NAD(P) binding site [chemical binding]; other site 909952005988 catalytic Zn binding site [ion binding]; other site 909952005989 structural Zn binding site [ion binding]; other site 909952005990 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 909952005991 active site 909952005992 catalytic triad [active] 909952005993 oxyanion hole [active] 909952005994 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 909952005995 DNA binding residues [nucleotide binding] 909952005996 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 909952005997 putative dimer interface [polypeptide binding]; other site 909952005998 chaperone protein DnaJ; Provisional; Region: PRK14295 909952005999 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 909952006000 HSP70 interaction site [polypeptide binding]; other site 909952006001 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 909952006002 Zn binding sites [ion binding]; other site 909952006003 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 909952006004 dimer interface [polypeptide binding]; other site 909952006005 GrpE; Region: GrpE; pfam01025 909952006006 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 909952006007 dimer interface [polypeptide binding]; other site 909952006008 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 909952006009 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 909952006010 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 909952006011 nucleotide binding site [chemical binding]; other site 909952006012 NEF interaction site [polypeptide binding]; other site 909952006013 SBD interface [polypeptide binding]; other site 909952006014 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 909952006015 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 909952006016 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 909952006017 active site 909952006018 phosphorylation site [posttranslational modification] 909952006019 intermolecular recognition site; other site 909952006020 dimerization interface [polypeptide binding]; other site 909952006021 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 909952006022 DNA binding site [nucleotide binding] 909952006023 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 909952006024 intersubunit interface [polypeptide binding]; other site 909952006025 active site 909952006026 catalytic residue [active] 909952006027 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1; cd01653 909952006028 conserved cys residue [active] 909952006029 FHA domain; Region: FHA; pfam00498 909952006030 phosphopeptide binding site; other site 909952006031 pyruvate phosphate dikinase; Provisional; Region: PRK09279 909952006032 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 909952006033 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 909952006034 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 909952006035 PEP synthetase regulatory protein; Provisional; Region: PRK05339 909952006036 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 909952006037 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 909952006038 S-adenosylmethionine binding site [chemical binding]; other site 909952006039 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 909952006040 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 909952006041 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 909952006042 active site 909952006043 catalytic residues [active] 909952006044 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 909952006045 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 909952006046 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 909952006047 Amidase; Region: Amidase; cl11426 909952006048 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 909952006049 Amidase; Region: Amidase; cl11426 909952006050 potential protein location (hypothetical protein PAZ_c21440 [Propionibacterium acnes 266]) that overlaps RNA (tRNA-G) 909952006051 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 909952006052 putative active site [active] 909952006053 homotetrameric interface [polypeptide binding]; other site 909952006054 metal binding site [ion binding]; metal-binding site 909952006055 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 909952006056 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 909952006057 active site 909952006058 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 909952006059 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 909952006060 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 909952006061 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 909952006062 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 909952006063 Walker A/P-loop; other site 909952006064 ATP binding site [chemical binding]; other site 909952006065 Q-loop/lid; other site 909952006066 ABC transporter signature motif; other site 909952006067 Walker B; other site 909952006068 D-loop; other site 909952006069 H-loop/switch region; other site 909952006070 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 909952006071 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 909952006072 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 909952006073 Walker A/P-loop; other site 909952006074 ATP binding site [chemical binding]; other site 909952006075 Q-loop/lid; other site 909952006076 ABC transporter signature motif; other site 909952006077 Walker B; other site 909952006078 D-loop; other site 909952006079 H-loop/switch region; other site 909952006080 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; cl09823 909952006081 EcsC protein family; Region: EcsC; pfam12787 909952006082 Uncharacterized conserved protein [Function unknown]; Region: COG2966 909952006083 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 909952006084 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 909952006085 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 909952006086 E3 interaction surface; other site 909952006087 lipoyl attachment site [posttranslational modification]; other site 909952006088 e3 binding domain; Region: E3_binding; pfam02817 909952006089 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 909952006090 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 909952006091 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 909952006092 alpha subunit interface [polypeptide binding]; other site 909952006093 TPP binding site [chemical binding]; other site 909952006094 heterodimer interface [polypeptide binding]; other site 909952006095 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 909952006096 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 909952006097 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 909952006098 TPP-binding site [chemical binding]; other site 909952006099 tetramer interface [polypeptide binding]; other site 909952006100 heterodimer interface [polypeptide binding]; other site 909952006101 phosphorylation loop region [posttranslational modification] 909952006102 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 909952006103 radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053 909952006104 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 909952006105 FeS/SAM binding site; other site 909952006106 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 909952006107 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 909952006108 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 909952006109 active site 909952006110 metal binding site [ion binding]; metal-binding site 909952006111 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 909952006112 H-loop/switch region; other site 909952006113 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 909952006114 WYL domain; Region: WYL; pfam13280 909952006115 WYL domain; Region: WYL; cl14852 909952006116 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 909952006117 active site 909952006118 Integrase core domain; Region: rve_3; pfam13683 909952006119 Lipase (class 2); Region: Lipase_2; pfam01674 909952006120 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 909952006121 CAMP factor (Cfa); Region: CAMP_factor; pfam07373 909952006122 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 909952006123 Low molecular weight phosphatase family; Region: LMWPc; cd00115 909952006124 active site 909952006125 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 909952006126 proposed catalytic triad [active] 909952006127 active site nucleophile [active] 909952006128 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 909952006129 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 909952006130 active site 909952006131 phosphorylation site [posttranslational modification] 909952006132 intermolecular recognition site; other site 909952006133 dimerization interface [polypeptide binding]; other site 909952006134 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 909952006135 DNA binding site [nucleotide binding] 909952006136 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 909952006137 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 909952006138 dimerization interface [polypeptide binding]; other site 909952006139 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 909952006140 dimer interface [polypeptide binding]; other site 909952006141 phosphorylation site [posttranslational modification] 909952006142 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 909952006143 ATP binding site [chemical binding]; other site 909952006144 Mg2+ binding site [ion binding]; other site 909952006145 G-X-G motif; other site 909952006146 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 909952006147 nudix motif; other site 909952006148 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 909952006149 YCII-related domain; Region: YCII; cl00999 909952006150 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 909952006151 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 909952006152 active site 909952006153 FMN binding site [chemical binding]; other site 909952006154 substrate binding site [chemical binding]; other site 909952006155 homotetramer interface [polypeptide binding]; other site 909952006156 catalytic residue [active] 909952006157 metabolite-proton symporter; Region: 2A0106; TIGR00883 909952006158 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909952006159 putative substrate translocation pore; other site 909952006160 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK06539 909952006161 ATP cone domain; Region: ATP-cone; pfam03477 909952006162 Class I ribonucleotide reductase; Region: RNR_I; cd01679 909952006163 active site 909952006164 dimer interface [polypeptide binding]; other site 909952006165 catalytic residues [active] 909952006166 effector binding site; other site 909952006167 R2 peptide binding site; other site 909952006168 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 909952006169 dimer interface [polypeptide binding]; other site 909952006170 putative radical transfer pathway; other site 909952006171 diiron center [ion binding]; other site 909952006172 tyrosyl radical; other site 909952006173 Bacterial PH domain; Region: DUF304; pfam03703 909952006174 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 909952006175 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 909952006176 nucleotide binding site [chemical binding]; other site 909952006177 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 909952006178 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 909952006179 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 909952006180 arginine-tRNA ligase; Region: PLN02286 909952006181 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 909952006182 active site 909952006183 HIGH motif; other site 909952006184 KMSK motif region; other site 909952006185 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 909952006186 tRNA binding surface [nucleotide binding]; other site 909952006187 anticodon binding site; other site 909952006188 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 909952006189 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 909952006190 active site 909952006191 catalytic tetrad [active] 909952006192 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 909952006193 putative active site [active] 909952006194 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 909952006195 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 909952006196 active site 909952006197 dimer interface [polypeptide binding]; other site 909952006198 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 909952006199 dimer interface [polypeptide binding]; other site 909952006200 active site 909952006201 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 909952006202 active site 909952006203 intersubunit interface [polypeptide binding]; other site 909952006204 catalytic residue [active] 909952006205 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 909952006206 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 909952006207 dimerization interface [polypeptide binding]; other site 909952006208 DPS ferroxidase diiron center [ion binding]; other site 909952006209 ion pore; other site 909952006210 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 909952006211 ATP binding site [chemical binding]; other site 909952006212 putative Mg++ binding site [ion binding]; other site 909952006213 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 909952006214 nucleotide binding region [chemical binding]; other site 909952006215 ATP-binding site [chemical binding]; other site 909952006216 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 909952006217 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 909952006218 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 909952006219 FeS/SAM binding site; other site 909952006220 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK07111 909952006221 ATP cone domain; Region: ATP-cone; pfam03477 909952006222 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 909952006223 Class III ribonucleotide reductase; Region: RNR_III; cd01675 909952006224 active site 909952006225 Zn binding site [ion binding]; other site 909952006226 glycine loop; other site 909952006227 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 909952006228 substrate binding site [chemical binding]; other site 909952006229 Cutinase; Region: Cutinase; pfam01083 909952006230 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 909952006231 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 909952006232 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 909952006233 NodB motif; other site 909952006234 active site 909952006235 catalytic site [active] 909952006236 metal binding site [ion binding]; metal-binding site 909952006237 TIGR03943 family protein; Region: TIGR03943 909952006238 Predicted permease; Region: DUF318; cl17795 909952006239 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 909952006240 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 909952006241 NodB motif; other site 909952006242 active site 909952006243 catalytic site [active] 909952006244 metal binding site [ion binding]; metal-binding site 909952006245 integral membrane protein MviN; Region: mviN; TIGR01695 909952006246 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 909952006247 aspartate kinase; Reviewed; Region: PRK06635 909952006248 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 909952006249 putative nucleotide binding site [chemical binding]; other site 909952006250 putative catalytic residues [active] 909952006251 putative Mg ion binding site [ion binding]; other site 909952006252 putative aspartate binding site [chemical binding]; other site 909952006253 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 909952006254 putative allosteric regulatory site; other site 909952006255 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 909952006256 putative allosteric regulatory residue; other site 909952006257 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 909952006258 Transglycosylase; Region: Transgly; pfam00912 909952006259 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 909952006260 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 909952006261 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 909952006262 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 909952006263 putative active site [active] 909952006264 putative metal binding site [ion binding]; other site 909952006265 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 909952006266 intracellular protease, PfpI family; Region: PfpI; TIGR01382 909952006267 proposed catalytic triad [active] 909952006268 conserved cys residue [active] 909952006269 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 909952006270 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 909952006271 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 909952006272 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 909952006273 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 909952006274 ABC-ATPase subunit interface; other site 909952006275 putative PBP binding loops; other site 909952006276 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 909952006277 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 909952006278 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 909952006279 dimer interface [polypeptide binding]; other site 909952006280 conserved gate region; other site 909952006281 putative PBP binding loops; other site 909952006282 ABC-ATPase subunit interface; other site 909952006283 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 909952006284 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 909952006285 Walker A/P-loop; other site 909952006286 ATP binding site [chemical binding]; other site 909952006287 Q-loop/lid; other site 909952006288 ABC transporter signature motif; other site 909952006289 Walker B; other site 909952006290 D-loop; other site 909952006291 H-loop/switch region; other site 909952006292 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 909952006293 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 909952006294 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 909952006295 Walker A/P-loop; other site 909952006296 ATP binding site [chemical binding]; other site 909952006297 Q-loop/lid; other site 909952006298 ABC transporter signature motif; other site 909952006299 Walker B; other site 909952006300 D-loop; other site 909952006301 H-loop/switch region; other site 909952006302 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 909952006303 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 909952006304 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 909952006305 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 909952006306 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 909952006307 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 909952006308 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 909952006309 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 909952006310 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 909952006311 urocanate hydratase; Provisional; Region: PRK05414 909952006312 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 909952006313 allantoate amidohydrolase; Reviewed; Region: PRK09290 909952006314 active site 909952006315 metal binding site [ion binding]; metal-binding site 909952006316 dimer interface [polypeptide binding]; other site 909952006317 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 909952006318 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 909952006319 active site 909952006320 imidazolonepropionase; Provisional; Region: PRK14085 909952006321 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 909952006322 active site 909952006323 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 909952006324 active sites [active] 909952006325 tetramer interface [polypeptide binding]; other site 909952006326 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 909952006327 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 909952006328 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 909952006329 Bacterial SH3 domain; Region: SH3_3; pfam08239 909952006330 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 909952006331 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 909952006332 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 909952006333 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 909952006334 potassium/proton antiporter; Reviewed; Region: PRK05326 909952006335 TrkA-C domain; Region: TrkA_C; pfam02080 909952006336 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 909952006337 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 909952006338 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 909952006339 nucleoside/Zn binding site; other site 909952006340 dimer interface [polypeptide binding]; other site 909952006341 catalytic motif [active] 909952006342 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 909952006343 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 909952006344 active site 909952006345 Uncharacterized conserved protein [Function unknown]; Region: COG3777 909952006346 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 909952006347 active site 909952006348 catalytic site [active] 909952006349 PA2301 is an uncharacterized Pseudomonas aeruginosa protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's...; Region: PA2301; cd04939 909952006350 putative deacylase active site [active] 909952006351 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 909952006352 K+ potassium transporter; Region: K_trans; pfam02705 909952006353 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 909952006354 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 909952006355 catalytic triad [active] 909952006356 Uncharacterized protein conserved in bacteria containing a divergent form of TPR repeats [Function unknown]; Region: COG4700 909952006357 Transcriptional regulator [Transcription]; Region: LytR; COG1316 909952006358 Transcriptional regulators [Transcription]; Region: PurR; COG1609 909952006359 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 909952006360 DNA binding site [nucleotide binding] 909952006361 domain linker motif; other site 909952006362 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 909952006363 ligand binding site [chemical binding]; other site 909952006364 dimerization interface (open form) [polypeptide binding]; other site 909952006365 dimerization interface (closed form) [polypeptide binding]; other site 909952006366 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 909952006367 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 909952006368 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u2; cd11478 909952006369 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 909952006370 Na binding site [ion binding]; other site 909952006371 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 909952006372 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 909952006373 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 909952006374 NAD(P) binding site [chemical binding]; other site 909952006375 argininosuccinate synthase; Validated; Region: PRK05370 909952006376 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909952006377 putative substrate translocation pore; other site 909952006378 Major Facilitator Superfamily; Region: MFS_1; pfam07690 909952006379 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 909952006380 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 909952006381 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 909952006382 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 909952006383 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 909952006384 active site 909952006385 motif I; other site 909952006386 motif II; other site 909952006387 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 909952006388 thiazolylpeptide-type bacteriocin precursor; Region: thiopep_precurs; TIGR03892 909952006389 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 909952006390 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 909952006391 Walker A/P-loop; other site 909952006392 ATP binding site [chemical binding]; other site 909952006393 Q-loop/lid; other site 909952006394 ABC transporter signature motif; other site 909952006395 Walker B; other site 909952006396 D-loop; other site 909952006397 H-loop/switch region; other site 909952006398 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 909952006399 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 909952006400 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 909952006401 non-specific DNA binding site [nucleotide binding]; other site 909952006402 salt bridge; other site 909952006403 sequence-specific DNA binding site [nucleotide binding]; other site 909952006404 Cupin domain; Region: Cupin_2; pfam07883 909952006405 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 909952006406 B3/4 domain; Region: B3_4; pfam03483 909952006407 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 909952006408 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 909952006409 Na binding site [ion binding]; other site 909952006410 oxidoreductase; Provisional; Region: PRK10015 909952006411 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 909952006412 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 909952006413 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 909952006414 Ligand binding site [chemical binding]; other site 909952006415 Electron transfer flavoprotein domain; Region: ETF; pfam01012 909952006416 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 909952006417 CoA-transferase family III; Region: CoA_transf_3; pfam02515 909952006418 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 909952006419 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 909952006420 active site 909952006421 Transcriptional regulator [Transcription]; Region: IclR; COG1414 909952006422 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 909952006423 Bacterial transcriptional regulator; Region: IclR; pfam01614 909952006424 seryl-tRNA synthetase; Provisional; Region: PRK05431 909952006425 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 909952006426 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 909952006427 dimer interface [polypeptide binding]; other site 909952006428 active site 909952006429 motif 1; other site 909952006430 motif 2; other site 909952006431 motif 3; other site 909952006432 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 909952006433 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 909952006434 Siderophore-interacting protein; Region: SIP; pfam04954 909952006435 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 909952006436 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 909952006437 Ferritin-like domain; Region: Ferritin; pfam00210 909952006438 ferroxidase diiron center [ion binding]; other site 909952006439 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 909952006440 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 909952006441 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 909952006442 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 909952006443 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 909952006444 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 909952006445 dimer interface [polypeptide binding]; other site 909952006446 ssDNA binding site [nucleotide binding]; other site 909952006447 tetramer (dimer of dimers) interface [polypeptide binding]; other site 909952006448 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 909952006449 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 909952006450 active site residue [active] 909952006451 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 909952006452 active site 909952006453 phosphorylation site [posttranslational modification] 909952006454 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 909952006455 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 909952006456 active site 909952006457 P-loop; other site 909952006458 phosphorylation site [posttranslational modification] 909952006459 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 909952006460 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 909952006461 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 909952006462 acyl-activating enzyme (AAE) consensus motif; other site 909952006463 putative AMP binding site [chemical binding]; other site 909952006464 putative active site [active] 909952006465 putative CoA binding site [chemical binding]; other site 909952006466 endonuclease IV; Provisional; Region: PRK01060 909952006467 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 909952006468 AP (apurinic/apyrimidinic) site pocket; other site 909952006469 DNA interaction; other site 909952006470 Metal-binding active site; metal-binding site 909952006471 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 909952006472 classical (c) SDRs; Region: SDR_c; cd05233 909952006473 NAD(P) binding site [chemical binding]; other site 909952006474 active site 909952006475 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 909952006476 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 909952006477 putative acyl-acceptor binding pocket; other site 909952006478 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 909952006479 Domain of unknown function (DUF348); Region: DUF348; pfam03990 909952006480 Domain of unknown function (DUF348); Region: DUF348; pfam03990 909952006481 Domain of unknown function (DUF348); Region: DUF348; pfam03990 909952006482 G5 domain; Region: G5; pfam07501 909952006483 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 909952006484 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 909952006485 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 909952006486 metal-binding site [ion binding] 909952006487 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 909952006488 Soluble P-type ATPase [General function prediction only]; Region: COG4087 909952006489 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 909952006490 metal-binding site [ion binding] 909952006491 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 909952006492 putative homodimer interface [polypeptide binding]; other site 909952006493 putative homotetramer interface [polypeptide binding]; other site 909952006494 putative allosteric switch controlling residues; other site 909952006495 putative metal binding site [ion binding]; other site 909952006496 putative homodimer-homodimer interface [polypeptide binding]; other site 909952006497 replicative DNA helicase; Region: DnaB; TIGR00665 909952006498 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 909952006499 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 909952006500 Walker A motif; other site 909952006501 ATP binding site [chemical binding]; other site 909952006502 Walker B motif; other site 909952006503 DNA binding loops [nucleotide binding] 909952006504 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 909952006505 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 909952006506 putative NAD(P) binding site [chemical binding]; other site 909952006507 dimer interface [polypeptide binding]; other site 909952006508 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 909952006509 active site 909952006510 DNA binding site [nucleotide binding] 909952006511 sn-glycerol-3-phosphate dehydrogenase subunit C; Provisional; Region: glpC; PRK11168 909952006512 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 909952006513 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 909952006514 glycerol-3-phosphate dehydrogenase, anaerobic, A subunit; Region: glycerol3P_GlpA; TIGR03377 909952006515 hydroxyglutarate oxidase; Provisional; Region: PRK11728 909952006516 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 909952006517 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 909952006518 dimerization interface [polypeptide binding]; other site 909952006519 ligand binding site [chemical binding]; other site 909952006520 NADP binding site [chemical binding]; other site 909952006521 catalytic site [active] 909952006522 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 909952006523 MarR family; Region: MarR_2; cl17246 909952006524 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 909952006525 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 909952006526 Cl- selectivity filter; other site 909952006527 Cl- binding residues [ion binding]; other site 909952006528 pore gating glutamate residue; other site 909952006529 dimer interface [polypeptide binding]; other site 909952006530 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 909952006531 Transcriptional regulators [Transcription]; Region: MarR; COG1846 909952006532 MarR family; Region: MarR_2; pfam12802 909952006533 MarR family; Region: MarR_2; cl17246 909952006534 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 909952006535 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 909952006536 active site 909952006537 metal binding site [ion binding]; metal-binding site 909952006538 DNA binding site [nucleotide binding] 909952006539 Predicted ATPases [General function prediction only]; Region: COG1106 909952006540 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 909952006541 Uncharacterized conserved protein [Function unknown]; Region: COG4717 909952006542 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 909952006543 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 909952006544 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 909952006545 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 909952006546 WHG domain; Region: WHG; pfam13305 909952006547 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 909952006548 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 909952006549 pyridoxal 5'-phosphate binding site [chemical binding]; other site 909952006550 catalytic residue [active] 909952006551 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 909952006552 putative deacylase active site [active] 909952006553 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 909952006554 NAD synthetase; Reviewed; Region: nadE; PRK02628 909952006555 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 909952006556 multimer interface [polypeptide binding]; other site 909952006557 active site 909952006558 catalytic triad [active] 909952006559 protein interface 1 [polypeptide binding]; other site 909952006560 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 909952006561 homodimer interface [polypeptide binding]; other site 909952006562 NAD binding pocket [chemical binding]; other site 909952006563 ATP binding pocket [chemical binding]; other site 909952006564 Mg binding site [ion binding]; other site 909952006565 active-site loop [active] 909952006566 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 909952006567 6-phosphofructokinase, eukaryotic type; Region: 6PF1K_euk; TIGR02478 909952006568 active site 909952006569 ADP/pyrophosphate binding site [chemical binding]; other site 909952006570 dimerization interface [polypeptide binding]; other site 909952006571 allosteric effector site; other site 909952006572 fructose-1,6-bisphosphate binding site; other site 909952006573 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 909952006574 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 909952006575 hexamer interface [polypeptide binding]; other site 909952006576 ligand binding site [chemical binding]; other site 909952006577 putative active site [active] 909952006578 NAD(P) binding site [chemical binding]; other site 909952006579 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 909952006580 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 909952006581 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 909952006582 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 909952006583 Bacterial SH3 domain; Region: SH3_3; pfam08239 909952006584 Bacterial SH3 domain; Region: SH3_3; pfam08239 909952006585 Bacterial SH3 domain; Region: SH3_4; pfam06347 909952006586 Bacterial SH3 domain; Region: SH3_4; pfam06347 909952006587 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 909952006588 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 909952006589 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 909952006590 dimer interface [polypeptide binding]; other site 909952006591 Citrate synthase; Region: Citrate_synt; pfam00285 909952006592 active site 909952006593 citrylCoA binding site [chemical binding]; other site 909952006594 NADH binding [chemical binding]; other site 909952006595 cationic pore residues; other site 909952006596 oxalacetate/citrate binding site [chemical binding]; other site 909952006597 coenzyme A binding site [chemical binding]; other site 909952006598 catalytic triad [active] 909952006599 adenosine deaminase; Provisional; Region: PRK09358 909952006600 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 909952006601 active site 909952006602 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 909952006603 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 909952006604 hexamer interface [polypeptide binding]; other site 909952006605 ligand binding site [chemical binding]; other site 909952006606 putative active site [active] 909952006607 NAD(P) binding site [chemical binding]; other site 909952006608 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 909952006609 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 909952006610 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 909952006611 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 909952006612 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 909952006613 catalytic residue [active] 909952006614 D-Lysine 5,6-aminomutase alpha subunit; Region: Lys-AminoMut_A; pfam09043 909952006615 D-Lysine 5,6-aminomutase alpha subunit; Region: Lys-AminoMut_A; pfam09043 909952006616 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 909952006617 B12 binding site [chemical binding]; other site 909952006618 MutL protein; Region: MutL; pfam13941 909952006619 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 909952006620 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815 909952006621 active site 909952006622 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 909952006623 dimer interface [polypeptide binding]; other site 909952006624 substrate binding site [chemical binding]; other site 909952006625 catalytic residue [active] 909952006626 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 909952006627 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 909952006628 alanine racemase; Reviewed; Region: alr; PRK00053 909952006629 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 909952006630 active site 909952006631 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 909952006632 dimer interface [polypeptide binding]; other site 909952006633 substrate binding site [chemical binding]; other site 909952006634 catalytic residues [active] 909952006635 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 909952006636 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 909952006637 active site 909952006638 substrate binding site [chemical binding]; other site 909952006639 metal binding site [ion binding]; metal-binding site 909952006640 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 909952006641 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 909952006642 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 909952006643 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 909952006644 active site 909952006645 Substrate binding site; other site 909952006646 Mg++ binding site; other site 909952006647 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 909952006648 putative active site [active] 909952006649 fumarate hydratase; Reviewed; Region: fumC; PRK00485 909952006650 Class II fumarases; Region: Fumarase_classII; cd01362 909952006651 active site 909952006652 tetramer interface [polypeptide binding]; other site 909952006653 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 909952006654 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 909952006655 dimer interface [polypeptide binding]; other site 909952006656 conserved gate region; other site 909952006657 putative PBP binding loops; other site 909952006658 ABC-ATPase subunit interface; other site 909952006659 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 909952006660 dimer interface [polypeptide binding]; other site 909952006661 conserved gate region; other site 909952006662 putative PBP binding loops; other site 909952006663 ABC-ATPase subunit interface; other site 909952006664 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 909952006665 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 909952006666 Transcriptional regulators [Transcription]; Region: PurR; COG1609 909952006667 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 909952006668 DNA binding site [nucleotide binding] 909952006669 domain linker motif; other site 909952006670 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 909952006671 putative dimerization interface [polypeptide binding]; other site 909952006672 putative ligand binding site [chemical binding]; other site 909952006673 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 909952006674 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 909952006675 Mechanosensitive ion channel; Region: MS_channel; pfam00924 909952006676 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 909952006677 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 909952006678 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 909952006679 active site 909952006680 NTP binding site [chemical binding]; other site 909952006681 metal binding triad [ion binding]; metal-binding site 909952006682 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 909952006683 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 909952006684 Zn2+ binding site [ion binding]; other site 909952006685 Mg2+ binding site [ion binding]; other site 909952006686 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 909952006687 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 909952006688 ATP binding site [chemical binding]; other site 909952006689 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 909952006690 glycerol kinase; Provisional; Region: glpK; PRK00047 909952006691 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 909952006692 N- and C-terminal domain interface [polypeptide binding]; other site 909952006693 active site 909952006694 MgATP binding site [chemical binding]; other site 909952006695 catalytic site [active] 909952006696 metal binding site [ion binding]; metal-binding site 909952006697 putative homotetramer interface [polypeptide binding]; other site 909952006698 glycerol binding site [chemical binding]; other site 909952006699 homodimer interface [polypeptide binding]; other site 909952006700 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 909952006701 amphipathic channel; other site 909952006702 Asn-Pro-Ala signature motifs; other site 909952006703 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 909952006704 Helix-turn-helix domain; Region: HTH_28; pfam13518 909952006705 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 909952006706 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 909952006707 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 909952006708 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 909952006709 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 909952006710 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 909952006711 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 909952006712 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 909952006713 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 909952006714 probable active site [active] 909952006715 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 909952006716 putative substrate translocation pore; other site 909952006717 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 909952006718 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 909952006719 substrate binding pocket [chemical binding]; other site 909952006720 OsmC-like protein; Region: OsmC; pfam02566 909952006721 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 909952006722 catalytic residues [active] 909952006723 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 909952006724 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 909952006725 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 909952006726 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 909952006727 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 909952006728 non-specific DNA interactions [nucleotide binding]; other site 909952006729 DNA binding site [nucleotide binding] 909952006730 sequence specific DNA binding site [nucleotide binding]; other site 909952006731 putative cAMP binding site [chemical binding]; other site 909952006732 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 909952006733 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 909952006734 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 909952006735 TPP-binding site [chemical binding]; other site 909952006736 dimer interface [polypeptide binding]; other site 909952006737 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 909952006738 PYR/PP interface [polypeptide binding]; other site 909952006739 dimer interface [polypeptide binding]; other site 909952006740 TPP binding site [chemical binding]; other site 909952006741 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 909952006742 ribulokinase; Provisional; Region: PRK04123 909952006743 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 909952006744 N- and C-terminal domain interface [polypeptide binding]; other site 909952006745 active site 909952006746 MgATP binding site [chemical binding]; other site 909952006747 catalytic site [active] 909952006748 metal binding site [ion binding]; metal-binding site 909952006749 carbohydrate binding site [chemical binding]; other site 909952006750 homodimer interface [polypeptide binding]; other site 909952006751 Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175 909952006752 active site 909952006753 metal binding site [ion binding]; metal-binding site 909952006754 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 909952006755 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 909952006756 active site 909952006757 motif I; other site 909952006758 motif II; other site 909952006759 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 909952006760 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 909952006761 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 909952006762 active site 909952006763 Zn2+ binding site [ion binding]; other site 909952006764 intersubunit interface [polypeptide binding]; other site 909952006765 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 909952006766 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 909952006767 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 909952006768 mannonate dehydratase; Provisional; Region: PRK03906 909952006769 mannonate dehydratase; Region: uxuA; TIGR00695 909952006770 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 909952006771 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 909952006772 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 909952006773 glucuronate isomerase; Reviewed; Region: PRK02925 909952006774 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 909952006775 Transcriptional regulators [Transcription]; Region: PurR; COG1609 909952006776 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 909952006777 DNA binding site [nucleotide binding] 909952006778 domain linker motif; other site 909952006779 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 909952006780 dimerization interface [polypeptide binding]; other site 909952006781 ligand binding site [chemical binding]; other site 909952006782 MFS/sugar transport protein; Region: MFS_2; pfam13347 909952006783 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 909952006784 beta-D-glucuronidase; Provisional; Region: PRK10150 909952006785 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 909952006786 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 909952006787 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 909952006788 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 909952006789 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 909952006790 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 909952006791 pyridoxal 5'-phosphate binding site [chemical binding]; other site 909952006792 homodimer interface [polypeptide binding]; other site 909952006793 catalytic residue [active] 909952006794 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 909952006795 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 909952006796 ATP-grasp domain; Region: ATP-grasp_4; cl17255 909952006797 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 909952006798 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 909952006799 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 909952006800 ParB-like nuclease domain; Region: ParB; smart00470 909952006801 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 909952006802 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 909952006803 P-loop; other site 909952006804 Magnesium ion binding site [ion binding]; other site 909952006805 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 909952006806 Magnesium ion binding site [ion binding]; other site 909952006807 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 909952006808 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 909952006809 Alanine racemase, N-terminal domain; Region: Ala_racemase_N; pfam01168 909952006810 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 909952006811 catalytic residue [active] 909952006812 FemAB family; Region: FemAB; pfam02388 909952006813 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 909952006814 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 909952006815 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 909952006816 G-X-X-G motif; other site 909952006817 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 909952006818 RxxxH motif; other site 909952006819 putative inner membrane protein translocase component YidC; Provisional; Region: PRK01315 909952006820 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 909952006821 Haemolytic domain; Region: Haemolytic; pfam01809 909952006822 Ribonuclease P; Region: Ribonuclease_P; pfam00825 909952006823 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399