-- dump date 20140620_000655 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1031709000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1031709000002 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 1031709000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1031709000004 Walker A motif; other site 1031709000005 ATP binding site [chemical binding]; other site 1031709000006 Walker B motif; other site 1031709000007 arginine finger; other site 1031709000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1031709000009 DnaA box-binding interface [nucleotide binding]; other site 1031709000010 DNA polymerase III subunit beta; Validated; Region: PRK07761 1031709000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1031709000012 putative DNA binding surface [nucleotide binding]; other site 1031709000013 dimer interface [polypeptide binding]; other site 1031709000014 beta-clamp/clamp loader binding surface; other site 1031709000015 beta-clamp/translesion DNA polymerase binding surface; other site 1031709000016 recombination protein F; Reviewed; Region: recF; PRK00064 1031709000017 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1031709000018 Walker A/P-loop; other site 1031709000019 ATP binding site [chemical binding]; other site 1031709000020 Q-loop/lid; other site 1031709000021 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1031709000022 ABC transporter signature motif; other site 1031709000023 Walker B; other site 1031709000024 D-loop; other site 1031709000025 H-loop/switch region; other site 1031709000026 Protein of unknown function (DUF721); Region: DUF721; cl02324 1031709000027 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1031709000028 ABC transporter signature motif; other site 1031709000029 Walker B; other site 1031709000030 D-loop; other site 1031709000031 H-loop/switch region; other site 1031709000032 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1031709000033 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 1031709000034 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 1031709000035 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1031709000036 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1031709000037 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1031709000038 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1031709000039 Mg2+ binding site [ion binding]; other site 1031709000040 G-X-G motif; other site 1031709000041 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1031709000042 anchoring element; other site 1031709000043 dimer interface [polypeptide binding]; other site 1031709000044 ATP binding site [chemical binding]; other site 1031709000045 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1031709000046 active site 1031709000047 putative metal-binding site [ion binding]; other site 1031709000048 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1031709000049 DNA gyrase subunit A; Validated; Region: PRK05560 1031709000050 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1031709000051 CAP-like domain; other site 1031709000052 active site 1031709000053 primary dimer interface [polypeptide binding]; other site 1031709000054 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1031709000055 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1031709000056 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1031709000057 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1031709000058 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1031709000059 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 1031709000060 A subgroup of L-lactate dehydrogenases; Region: LDH_3; cd05290 1031709000061 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 1031709000062 NAD binding site [chemical binding]; other site 1031709000063 dimer interface [polypeptide binding]; other site 1031709000064 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1031709000065 substrate binding site [chemical binding]; other site 1031709000066 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1031709000067 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1031709000068 DNA binding site [nucleotide binding] 1031709000069 domain linker motif; other site 1031709000070 Ligand-binding domain of DNA-binding regulatory protein from Corynebacterium glutamicum which has a unique ability to produce significant amounts of L-glutamate directly from cheap sugar and ammonia; Region: PBP1_LacI_like_13; cd06299 1031709000071 dimerization interface [polypeptide binding]; other site 1031709000072 putative ligand binding site [chemical binding]; other site 1031709000073 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1031709000074 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1031709000075 Walker A/P-loop; other site 1031709000076 ATP binding site [chemical binding]; other site 1031709000077 Q-loop/lid; other site 1031709000078 ABC transporter signature motif; other site 1031709000079 Walker B; other site 1031709000080 D-loop; other site 1031709000081 H-loop/switch region; other site 1031709000082 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1031709000083 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1031709000084 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1031709000085 TM-ABC transporter signature motif; other site 1031709000086 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 1031709000087 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1031709000088 ligand binding site [chemical binding]; other site 1031709000089 dimerization interface [polypeptide binding]; other site 1031709000090 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1031709000091 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1031709000092 substrate binding site [chemical binding]; other site 1031709000093 dimer interface [polypeptide binding]; other site 1031709000094 ATP binding site [chemical binding]; other site 1031709000095 D-ribose pyranase; Provisional; Region: PRK11797 1031709000096 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1031709000097 active site 1031709000098 phosphorylation site [posttranslational modification] 1031709000099 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 1031709000100 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 1031709000101 active site 1031709000102 P-loop; other site 1031709000103 phosphorylation site [posttranslational modification] 1031709000104 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1031709000105 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1031709000106 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1031709000107 potential frameshift: common BLAST hit: gi|365972944|ref|YP_004954503.1| HTH domain protein 1031709000108 HTH domain; Region: HTH_11; cl17392 1031709000109 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1031709000110 active site 1031709000111 phosphorylation site [posttranslational modification] 1031709000112 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1031709000113 putative phosphatase; Provisional; Region: PRK11587 1031709000114 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1031709000115 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1031709000116 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1031709000117 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 1031709000118 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1031709000119 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1031709000120 homodimer interface [polypeptide binding]; other site 1031709000121 catalytic residue [active] 1031709000122 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 1031709000123 active site 1031709000124 nucleophile elbow; other site 1031709000125 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1031709000126 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1031709000127 Coenzyme A binding pocket [chemical binding]; other site 1031709000128 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 1031709000129 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 1031709000130 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1031709000131 Walker A motif; other site 1031709000132 ATP binding site [chemical binding]; other site 1031709000133 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1031709000134 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1031709000135 Bacterial transcriptional activator domain; Region: BTAD; smart01043 1031709000136 H+ Antiporter protein; Region: 2A0121; TIGR00900 1031709000137 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 1031709000138 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 1031709000139 Potassium binding sites [ion binding]; other site 1031709000140 Cesium cation binding sites [ion binding]; other site 1031709000141 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 1031709000142 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1031709000143 FtsX-like permease family; Region: FtsX; pfam02687 1031709000144 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1031709000145 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1031709000146 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1031709000147 Walker A/P-loop; other site 1031709000148 ATP binding site [chemical binding]; other site 1031709000149 Q-loop/lid; other site 1031709000150 ABC transporter signature motif; other site 1031709000151 Walker B; other site 1031709000152 D-loop; other site 1031709000153 H-loop/switch region; other site 1031709000154 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1031709000155 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1031709000156 active site 1031709000157 phosphorylation site [posttranslational modification] 1031709000158 intermolecular recognition site; other site 1031709000159 dimerization interface [polypeptide binding]; other site 1031709000160 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1031709000161 DNA binding residues [nucleotide binding] 1031709000162 dimerization interface [polypeptide binding]; other site 1031709000163 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1031709000164 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1031709000165 dimer interface [polypeptide binding]; other site 1031709000166 conserved gate region; other site 1031709000167 putative PBP binding loops; other site 1031709000168 ABC-ATPase subunit interface; other site 1031709000169 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1031709000170 dimer interface [polypeptide binding]; other site 1031709000171 conserved gate region; other site 1031709000172 putative PBP binding loops; other site 1031709000173 ABC-ATPase subunit interface; other site 1031709000174 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1031709000175 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1031709000176 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1031709000177 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1031709000178 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1031709000179 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1031709000180 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 1031709000181 NAD binding site [chemical binding]; other site 1031709000182 sugar binding site [chemical binding]; other site 1031709000183 divalent metal binding site [ion binding]; other site 1031709000184 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1031709000185 dimer interface [polypeptide binding]; other site 1031709000186 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 1031709000187 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 1031709000188 active site 1031709000189 catalytic site [active] 1031709000190 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 1031709000191 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 1031709000192 Sulfatase; Region: Sulfatase; cl17466 1031709000193 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 1031709000194 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1031709000195 motif II; other site 1031709000196 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 1031709000197 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 1031709000198 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 1031709000199 active site 1031709000200 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1031709000201 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1031709000202 substrate binding site [chemical binding]; other site 1031709000203 ATP binding site [chemical binding]; other site 1031709000204 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1031709000205 Histidine kinase; Region: HisKA_3; pfam07730 1031709000206 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1031709000207 ATP binding site [chemical binding]; other site 1031709000208 Mg2+ binding site [ion binding]; other site 1031709000209 G-X-G motif; other site 1031709000210 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1031709000211 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1031709000212 NAD(P) binding site [chemical binding]; other site 1031709000213 active site 1031709000214 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1031709000215 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1031709000216 MMPL family; Region: MMPL; pfam03176 1031709000217 MMPL family; Region: MMPL; pfam03176 1031709000218 Predicted membrane protein [Function unknown]; Region: COG1511 1031709000219 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1031709000220 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1031709000221 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1031709000222 Walker A/P-loop; other site 1031709000223 ATP binding site [chemical binding]; other site 1031709000224 Q-loop/lid; other site 1031709000225 ABC transporter signature motif; other site 1031709000226 Walker B; other site 1031709000227 D-loop; other site 1031709000228 H-loop/switch region; other site 1031709000229 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1031709000230 S-adenosylmethionine binding site [chemical binding]; other site 1031709000231 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 1031709000232 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 1031709000233 putative ligand binding residues [chemical binding]; other site 1031709000234 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1031709000235 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1031709000236 ABC-ATPase subunit interface; other site 1031709000237 dimer interface [polypeptide binding]; other site 1031709000238 putative PBP binding regions; other site 1031709000239 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1031709000240 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1031709000241 ABC transporter signature motif; other site 1031709000242 Walker B; other site 1031709000243 D-loop; other site 1031709000244 H-loop/switch region; other site 1031709000245 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1031709000246 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1031709000247 tetramerization interface [polypeptide binding]; other site 1031709000248 NAD(P) binding site [chemical binding]; other site 1031709000249 catalytic residues [active] 1031709000250 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1031709000251 Putative ClC chloride channel. Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033 1031709000252 putative ion selectivity filter; other site 1031709000253 putative pore gating glutamate residue; other site 1031709000254 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1031709000255 homodimer interface [polypeptide binding]; other site 1031709000256 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 1031709000257 active site pocket [active] 1031709000258 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1031709000259 DNA binding residues [nucleotide binding] 1031709000260 Lacto-N-biose phosphorylase; Region: Lact_bio_phlase; pfam09508 1031709000261 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase; Region: TIGR02336 1031709000262 MarR family; Region: MarR_2; pfam12802 1031709000263 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1031709000264 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1031709000265 carbohydrate ABC transporter substrate-binding protein, CPR_0540 family; Region: bind_CPR_0540; TIGR03850 1031709000266 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1031709000267 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1031709000268 dimer interface [polypeptide binding]; other site 1031709000269 conserved gate region; other site 1031709000270 putative PBP binding loops; other site 1031709000271 ABC-ATPase subunit interface; other site 1031709000272 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1031709000273 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1031709000274 dimer interface [polypeptide binding]; other site 1031709000275 conserved gate region; other site 1031709000276 putative PBP binding loops; other site 1031709000277 ABC-ATPase subunit interface; other site 1031709000278 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1031709000279 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1031709000280 DNA binding site [nucleotide binding] 1031709000281 domain linker motif; other site 1031709000282 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 1031709000283 ligand binding site [chemical binding]; other site 1031709000284 dimerization interface (open form) [polypeptide binding]; other site 1031709000285 dimerization interface (closed form) [polypeptide binding]; other site 1031709000286 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1031709000287 6-phosphofructokinase; Provisional; Region: PRK03202 1031709000288 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1031709000289 active site 1031709000290 ADP/pyrophosphate binding site [chemical binding]; other site 1031709000291 dimerization interface [polypeptide binding]; other site 1031709000292 allosteric effector site; other site 1031709000293 fructose-1,6-bisphosphate binding site; other site 1031709000294 Predicted transcriptional regulator [Transcription]; Region: COG2345 1031709000295 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1031709000296 putative DNA binding site [nucleotide binding]; other site 1031709000297 putative Zn2+ binding site [ion binding]; other site 1031709000298 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 1031709000299 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 1031709000300 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1031709000301 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1031709000302 Aspartase; Region: Aspartase; cd01357 1031709000303 active sites [active] 1031709000304 tetramer interface [polypeptide binding]; other site 1031709000305 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 1031709000306 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 1031709000307 Predicted acetyltransferase [General function prediction only]; Region: COG2388 1031709000308 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1031709000309 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 1031709000310 heme binding pocket [chemical binding]; other site 1031709000311 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1031709000312 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1031709000313 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1031709000314 Walker A/P-loop; other site 1031709000315 ATP binding site [chemical binding]; other site 1031709000316 Q-loop/lid; other site 1031709000317 ABC transporter signature motif; other site 1031709000318 Walker B; other site 1031709000319 D-loop; other site 1031709000320 H-loop/switch region; other site 1031709000321 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1031709000322 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1031709000323 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1031709000324 Q-loop/lid; other site 1031709000325 ABC transporter signature motif; other site 1031709000326 Walker B; other site 1031709000327 D-loop; other site 1031709000328 H-loop/switch region; other site 1031709000329 Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081 1031709000330 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1031709000331 Walker A motif; other site 1031709000332 ATP binding site [chemical binding]; other site 1031709000333 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 1031709000334 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1031709000335 Walker A motif; other site 1031709000336 ATP binding site [chemical binding]; other site 1031709000337 Walker B motif; other site 1031709000338 arginine finger; other site 1031709000339 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 1031709000340 metal ion-dependent adhesion site (MIDAS); other site 1031709000341 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1031709000342 CobN/Magnesium Chelatase; Region: CobN-Mg_chel; pfam02514 1031709000343 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1031709000344 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1031709000345 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1031709000346 FeS/SAM binding site; other site 1031709000347 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1031709000348 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1031709000349 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1031709000350 Walker A/P-loop; other site 1031709000351 ATP binding site [chemical binding]; other site 1031709000352 Q-loop/lid; other site 1031709000353 ABC transporter signature motif; other site 1031709000354 Walker B; other site 1031709000355 D-loop; other site 1031709000356 H-loop/switch region; other site 1031709000357 FecCD transport family; Region: FecCD; pfam01032 1031709000358 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1031709000359 ABC-ATPase subunit interface; other site 1031709000360 dimer interface [polypeptide binding]; other site 1031709000361 putative PBP binding regions; other site 1031709000362 Periplasmic binding protein TroA_d. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_d; cd01141 1031709000363 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1031709000364 putative ligand binding site [chemical binding]; other site 1031709000365 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1031709000366 Periplasmic binding protein TroA_d. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_d; cd01141 1031709000367 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1031709000368 putative ligand binding site [chemical binding]; other site 1031709000369 myosin-cross-reactive antigen; Provisional; Region: PRK13977 1031709000370 multifunctional hydroxymethylpyrimidine phosphokinase/4-amino-5-aminomethyl-2-methylpyrimidine hydrolase; Provisional; Region: PRK14713 1031709000371 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1031709000372 dimer interface [polypeptide binding]; other site 1031709000373 substrate binding site [chemical binding]; other site 1031709000374 ATP binding site [chemical binding]; other site 1031709000375 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 1031709000376 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1031709000377 thiamine phosphate binding site [chemical binding]; other site 1031709000378 active site 1031709000379 pyrophosphate binding site [ion binding]; other site 1031709000380 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1031709000381 putative active site [active] 1031709000382 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 1031709000383 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 1031709000384 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1031709000385 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1031709000386 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 1031709000387 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1031709000388 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1031709000389 Ligand Binding Site [chemical binding]; other site 1031709000390 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1031709000391 dimer interface [polypeptide binding]; other site 1031709000392 phosphorylation site [posttranslational modification] 1031709000393 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1031709000394 ATP binding site [chemical binding]; other site 1031709000395 Mg2+ binding site [ion binding]; other site 1031709000396 G-X-G motif; other site 1031709000397 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1031709000398 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1031709000399 active site 1031709000400 phosphorylation site [posttranslational modification] 1031709000401 intermolecular recognition site; other site 1031709000402 dimerization interface [polypeptide binding]; other site 1031709000403 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1031709000404 DNA binding site [nucleotide binding] 1031709000405 EXLDI protein; Region: EXLDI; TIGR04342 1031709000406 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1031709000407 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1031709000408 potential frameshift: common BLAST hit: gi|295129662|ref|YP_003580325.1| peptidase, M16 (pitrilysin) family 1031709000409 Transglycosylase; Region: Transgly; pfam00912 1031709000410 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1031709000411 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1031709000412 Mannosyltransferase (PIG-V)); Region: Mannosyl_trans2; pfam04188 1031709000413 This family is most closely related to the GT1 family of glycosyltransferases. AmsK is involved in the biosynthesis of amylovoran, which functions as a virulence factor. It functions as a glycosyl transferase which transfers galactose from UDP-galactose...; Region: GT1_AmsK_like; cd04946 1031709000414 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1031709000415 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1031709000416 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1031709000417 O-Antigen ligase; Region: Wzy_C; pfam04932 1031709000418 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 1031709000419 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1031709000420 putative trimer interface [polypeptide binding]; other site 1031709000421 putative CoA binding site [chemical binding]; other site 1031709000422 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 1031709000423 putative trimer interface [polypeptide binding]; other site 1031709000424 putative active site [active] 1031709000425 putative substrate binding site [chemical binding]; other site 1031709000426 putative CoA binding site [chemical binding]; other site 1031709000427 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1031709000428 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1031709000429 inhibitor-cofactor binding pocket; inhibition site 1031709000430 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1031709000431 catalytic residue [active] 1031709000432 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1031709000433 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1031709000434 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1031709000435 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 1031709000436 O-Antigen ligase; Region: Wzy_C; pfam04932 1031709000437 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1031709000438 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1031709000439 POT family; Region: PTR2; cl17359 1031709000440 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1031709000441 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1031709000442 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1031709000443 classical (c) SDRs; Region: SDR_c; cd05233 1031709000444 NAD(P) binding site [chemical binding]; other site 1031709000445 active site 1031709000446 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1031709000447 dimerization domain swap beta strand [polypeptide binding]; other site 1031709000448 regulatory protein interface [polypeptide binding]; other site 1031709000449 active site 1031709000450 regulatory phosphorylation site [posttranslational modification]; other site 1031709000451 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1031709000452 active site 1031709000453 phosphorylation site [posttranslational modification] 1031709000454 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1031709000455 active site 1031709000456 P-loop; other site 1031709000457 phosphorylation site [posttranslational modification] 1031709000458 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1031709000459 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1031709000460 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1031709000461 putative substrate binding site [chemical binding]; other site 1031709000462 putative ATP binding site [chemical binding]; other site 1031709000463 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1031709000464 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1031709000465 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1031709000466 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 1031709000467 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1031709000468 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1031709000469 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1031709000470 O-Antigen ligase; Region: Wzy_C; pfam04932 1031709000471 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1031709000472 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 1031709000473 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1031709000474 active site 1031709000475 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 1031709000476 homodimer interface [polypeptide binding]; other site 1031709000477 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1031709000478 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1031709000479 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1031709000480 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1031709000481 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1031709000482 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 1031709000483 nudix motif; other site 1031709000484 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 1031709000485 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1031709000486 ATP binding site [chemical binding]; other site 1031709000487 putative Mg++ binding site [ion binding]; other site 1031709000488 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1031709000489 nucleotide binding region [chemical binding]; other site 1031709000490 ATP-binding site [chemical binding]; other site 1031709000491 Helicase associated domain (HA2); Region: HA2; pfam04408 1031709000492 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 1031709000493 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 1031709000494 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1031709000495 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1031709000496 Walker A/P-loop; other site 1031709000497 ATP binding site [chemical binding]; other site 1031709000498 Q-loop/lid; other site 1031709000499 ABC transporter signature motif; other site 1031709000500 Walker B; other site 1031709000501 D-loop; other site 1031709000502 H-loop/switch region; other site 1031709000503 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1031709000504 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 1031709000505 Walker A/P-loop; other site 1031709000506 ATP binding site [chemical binding]; other site 1031709000507 Q-loop/lid; other site 1031709000508 ABC transporter signature motif; other site 1031709000509 Walker B; other site 1031709000510 D-loop; other site 1031709000511 H-loop/switch region; other site 1031709000512 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1031709000513 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1031709000514 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 1031709000515 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565 1031709000516 Dihydroorotate dehydrogenase (DHOD) like proteins. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_like; cd04739 1031709000517 putative active site [active] 1031709000518 putative FMN binding site [chemical binding]; other site 1031709000519 putative substrate binding site [chemical binding]; other site 1031709000520 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 1031709000521 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1031709000522 dimer interface [polypeptide binding]; other site 1031709000523 PYR/PP interface [polypeptide binding]; other site 1031709000524 TPP binding site [chemical binding]; other site 1031709000525 substrate binding site [chemical binding]; other site 1031709000526 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1031709000527 Domain of unknown function; Region: EKR; smart00890 1031709000528 4Fe-4S binding domain; Region: Fer4_6; pfam12837 1031709000529 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1031709000530 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 1031709000531 TPP-binding site [chemical binding]; other site 1031709000532 dimer interface [polypeptide binding]; other site 1031709000533 putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771 1031709000534 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1031709000535 4Fe-4S binding domain; Region: Fer4; pfam00037 1031709000536 Domain of unknown function DUF77; Region: DUF77; pfam01910 1031709000537 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1031709000538 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1031709000539 DNA-binding site [nucleotide binding]; DNA binding site 1031709000540 FCD domain; Region: FCD; pfam07729 1031709000541 L-lactate permease; Region: Lactate_perm; cl00701 1031709000542 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 1031709000543 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1031709000544 Cysteine-rich domain; Region: CCG; pfam02754 1031709000545 Cysteine-rich domain; Region: CCG; pfam02754 1031709000546 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 1031709000547 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1031709000548 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1031709000549 Uncharacterized conserved protein [Function unknown]; Region: COG1556 1031709000550 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1031709000551 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1031709000552 Walker A/P-loop; other site 1031709000553 ATP binding site [chemical binding]; other site 1031709000554 Q-loop/lid; other site 1031709000555 ABC transporter signature motif; other site 1031709000556 Walker B; other site 1031709000557 D-loop; other site 1031709000558 H-loop/switch region; other site 1031709000559 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 1031709000560 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1031709000561 Walker A/P-loop; other site 1031709000562 ATP binding site [chemical binding]; other site 1031709000563 Q-loop/lid; other site 1031709000564 ABC transporter signature motif; other site 1031709000565 Walker B; other site 1031709000566 D-loop; other site 1031709000567 H-loop/switch region; other site 1031709000568 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 1031709000569 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1031709000570 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1031709000571 Walker A/P-loop; other site 1031709000572 ATP binding site [chemical binding]; other site 1031709000573 Q-loop/lid; other site 1031709000574 ABC transporter signature motif; other site 1031709000575 Walker B; other site 1031709000576 D-loop; other site 1031709000577 H-loop/switch region; other site 1031709000578 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1031709000579 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1031709000580 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1031709000581 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1031709000582 Amino acid permease; Region: AA_permease_2; pfam13520 1031709000583 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1031709000584 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1031709000585 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1031709000586 Walker A/P-loop; other site 1031709000587 ATP binding site [chemical binding]; other site 1031709000588 Q-loop/lid; other site 1031709000589 ABC transporter signature motif; other site 1031709000590 Walker B; other site 1031709000591 D-loop; other site 1031709000592 H-loop/switch region; other site 1031709000593 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1031709000594 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1031709000595 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1031709000596 Walker A/P-loop; other site 1031709000597 ATP binding site [chemical binding]; other site 1031709000598 Q-loop/lid; other site 1031709000599 ABC transporter signature motif; other site 1031709000600 Walker B; other site 1031709000601 D-loop; other site 1031709000602 H-loop/switch region; other site 1031709000603 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1031709000604 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1031709000605 non-specific DNA binding site [nucleotide binding]; other site 1031709000606 salt bridge; other site 1031709000607 sequence-specific DNA binding site [nucleotide binding]; other site 1031709000608 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1031709000609 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1031709000610 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1031709000611 dimer interface [polypeptide binding]; other site 1031709000612 putative anticodon binding site; other site 1031709000613 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1031709000614 motif 1; other site 1031709000615 dimer interface [polypeptide binding]; other site 1031709000616 active site 1031709000617 motif 2; other site 1031709000618 motif 3; other site 1031709000619 Uncharacterized protein family (UPF0233); Region: UPF0233; pfam06781 1031709000620 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1031709000621 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1031709000622 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1031709000623 active site 1031709000624 ATP binding site [chemical binding]; other site 1031709000625 substrate binding site [chemical binding]; other site 1031709000626 activation loop (A-loop); other site 1031709000627 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1031709000628 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1031709000629 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1031709000630 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1031709000631 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 1031709000632 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1031709000633 active site 1031709000634 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1031709000635 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1031709000636 phosphopeptide binding site; other site 1031709000637 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 1031709000638 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1031709000639 phosphopeptide binding site; other site 1031709000640 Phosphotransferase enzyme family; Region: APH; pfam01636 1031709000641 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1031709000642 active site 1031709000643 ATP binding site [chemical binding]; other site 1031709000644 RHS Repeat; Region: RHS_repeat; cl11982 1031709000645 RHS Repeat; Region: RHS_repeat; pfam05593 1031709000646 RHS Repeat; Region: RHS_repeat; pfam05593 1031709000647 RHS Repeat; Region: RHS_repeat; cl11982 1031709000648 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 1031709000649 RHS Repeat; Region: RHS_repeat; pfam05593 1031709000650 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 1031709000651 RHS Repeat; Region: RHS_repeat; pfam05593 1031709000652 RHS Repeat; Region: RHS_repeat; cl11982 1031709000653 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 1031709000654 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1031709000655 RHS Repeat; Region: RHS_repeat; pfam05593 1031709000656 RHS Repeat; Region: RHS_repeat; pfam05593 1031709000657 RHS Repeat; Region: RHS_repeat; pfam05593 1031709000658 RHS Repeat; Region: RHS_repeat; pfam05593 1031709000659 RHS Repeat; Region: RHS_repeat; cl11982 1031709000660 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1031709000661 RHS Repeat; Region: RHS_repeat; cl11982 1031709000662 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1031709000663 RHS Repeat; Region: RHS_repeat; pfam05593 1031709000664 RHS Repeat; Region: RHS_repeat; pfam05593 1031709000665 RHS Repeat; Region: RHS_repeat; pfam05593 1031709000666 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 1031709000667 RHS Repeat; Region: RHS_repeat; pfam05593 1031709000668 RHS Repeat; Region: RHS_repeat; pfam05593 1031709000669 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1031709000670 RNA binding surface [nucleotide binding]; other site 1031709000671 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 1031709000672 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1031709000673 Walker A motif; other site 1031709000674 ATP binding site [chemical binding]; other site 1031709000675 Walker B motif; other site 1031709000676 arginine finger; other site 1031709000677 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1031709000678 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG0718 1031709000679 recombination protein RecR; Reviewed; Region: recR; PRK00076 1031709000680 RecR protein; Region: RecR; pfam02132 1031709000681 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1031709000682 putative active site [active] 1031709000683 putative metal-binding site [ion binding]; other site 1031709000684 tetramer interface [polypeptide binding]; other site 1031709000685 Predicted transcriptional regulators [Transcription]; Region: COG1695 1031709000686 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1031709000687 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1031709000688 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1031709000689 Walker A/P-loop; other site 1031709000690 ATP binding site [chemical binding]; other site 1031709000691 Q-loop/lid; other site 1031709000692 ABC transporter signature motif; other site 1031709000693 Walker B; other site 1031709000694 D-loop; other site 1031709000695 H-loop/switch region; other site 1031709000696 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1031709000697 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1031709000698 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1031709000699 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 1031709000700 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1031709000701 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1031709000702 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1031709000703 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1031709000704 active site 1031709000705 motif I; other site 1031709000706 motif II; other site 1031709000707 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1031709000708 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1031709000709 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 1031709000710 Walker A/P-loop; other site 1031709000711 ATP binding site [chemical binding]; other site 1031709000712 Q-loop/lid; other site 1031709000713 ABC transporter signature motif; other site 1031709000714 Walker B; other site 1031709000715 D-loop; other site 1031709000716 H-loop/switch region; other site 1031709000717 Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060 1031709000718 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1031709000719 active site 1031709000720 HIGH motif; other site 1031709000721 nucleotide binding site [chemical binding]; other site 1031709000722 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1031709000723 active site 1031709000724 KMSKS motif; other site 1031709000725 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 1031709000726 tRNA binding surface [nucleotide binding]; other site 1031709000727 anticodon binding site; other site 1031709000728 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 1031709000729 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 1031709000730 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1031709000731 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 1031709000732 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1031709000733 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1031709000734 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1031709000735 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 1031709000736 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 1031709000737 homotrimer interaction site [polypeptide binding]; other site 1031709000738 putative active site [active] 1031709000739 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1031709000740 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1031709000741 ligand binding site [chemical binding]; other site 1031709000742 flexible hinge region; other site 1031709000743 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1031709000744 putative switch regulator; other site 1031709000745 non-specific DNA interactions [nucleotide binding]; other site 1031709000746 DNA binding site [nucleotide binding] 1031709000747 sequence specific DNA binding site [nucleotide binding]; other site 1031709000748 putative cAMP binding site [chemical binding]; other site 1031709000749 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1031709000750 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1031709000751 minor groove reading motif; other site 1031709000752 helix-hairpin-helix signature motif; other site 1031709000753 substrate binding pocket [chemical binding]; other site 1031709000754 active site 1031709000755 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1031709000756 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1031709000757 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1031709000758 catalytic residues [active] 1031709000759 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1031709000760 putative active site [active] 1031709000761 putative CoA binding site [chemical binding]; other site 1031709000762 nudix motif; other site 1031709000763 metal binding site [ion binding]; metal-binding site 1031709000764 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 1031709000765 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1031709000766 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 1031709000767 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 1031709000768 helicase/secretion neighborhood ATPase; Region: heli_sec_ATPase; TIGR03819 1031709000769 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 1031709000770 Walker A motif; other site 1031709000771 ATP binding site [chemical binding]; other site 1031709000772 Walker B motif; other site 1031709000773 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1031709000774 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 1031709000775 helicase/secretion neighborhood TadE-like protein; Region: tadE_like_DECH; TIGR03816 1031709000776 Predicted ATPase [General function prediction only]; Region: COG4637 1031709000777 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 1031709000778 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1031709000779 ATP binding site [chemical binding]; other site 1031709000780 putative Mg++ binding site [ion binding]; other site 1031709000781 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1031709000782 nucleotide binding region [chemical binding]; other site 1031709000783 ATP-binding site [chemical binding]; other site 1031709000784 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1031709000785 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 1031709000786 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1031709000787 S-adenosylmethionine binding site [chemical binding]; other site 1031709000788 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 1031709000789 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1031709000790 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1031709000791 active site 1031709000792 interdomain interaction site; other site 1031709000793 putative metal-binding site [ion binding]; other site 1031709000794 nucleotide binding site [chemical binding]; other site 1031709000795 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1031709000796 domain I; other site 1031709000797 DNA binding groove [nucleotide binding] 1031709000798 phosphate binding site [ion binding]; other site 1031709000799 domain II; other site 1031709000800 domain III; other site 1031709000801 nucleotide binding site [chemical binding]; other site 1031709000802 catalytic site [active] 1031709000803 domain IV; other site 1031709000804 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1031709000805 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1031709000806 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1031709000807 thymidylate kinase; Validated; Region: tmk; PRK00698 1031709000808 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1031709000809 TMP-binding site; other site 1031709000810 ATP-binding site [chemical binding]; other site 1031709000811 DNA polymerase III subunit delta'; Validated; Region: PRK07940 1031709000812 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1031709000813 Walker A motif; other site 1031709000814 ATP binding site [chemical binding]; other site 1031709000815 Walker B motif; other site 1031709000816 arginine finger; other site 1031709000817 Predicted membrane protein [Function unknown]; Region: COG2259 1031709000818 PSP1 C-terminal conserved region; Region: PSP1; cl00770 1031709000819 TAP-like protein; Region: Abhydrolase_4; pfam08386 1031709000820 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 1031709000821 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 1031709000822 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1031709000823 catalytic core [active] 1031709000824 potential frameshift: common BLAST hit: gi|365973159|ref|YP_004954718.1| acetyl xylan esterase (AXE1) 1031709000825 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 1031709000826 potential frameshift: common BLAST hit: gi|365973159|ref|YP_004954718.1| acetyl xylan esterase (AXE1) 1031709000827 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 1031709000828 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1031709000829 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1031709000830 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1031709000831 dimer interface [polypeptide binding]; other site 1031709000832 substrate binding site [chemical binding]; other site 1031709000833 metal binding sites [ion binding]; metal-binding site 1031709000834 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 1031709000835 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1031709000836 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 1031709000837 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1031709000838 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1031709000839 Ligand Binding Site [chemical binding]; other site 1031709000840 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1031709000841 active site 1031709000842 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1031709000843 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1031709000844 Walker A motif; other site 1031709000845 ATP binding site [chemical binding]; other site 1031709000846 Walker B motif; other site 1031709000847 arginine finger; other site 1031709000848 Peptidase family M41; Region: Peptidase_M41; pfam01434 1031709000849 Protein of unknown function (DUF3729); Region: DUF3729; pfam12526 1031709000850 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1031709000851 homodecamer interface [polypeptide binding]; other site 1031709000852 GTP cyclohydrolase I; Provisional; Region: PLN03044 1031709000853 active site 1031709000854 putative catalytic site residues [active] 1031709000855 zinc binding site [ion binding]; other site 1031709000856 GTP-CH-I/GFRP interaction surface; other site 1031709000857 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1031709000858 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1031709000859 ligand binding site [chemical binding]; other site 1031709000860 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1031709000861 dihydropteroate synthase; Region: DHPS; TIGR01496 1031709000862 substrate binding pocket [chemical binding]; other site 1031709000863 dimer interface [polypeptide binding]; other site 1031709000864 inhibitor binding site; inhibition site 1031709000865 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1031709000866 homooctamer interface [polypeptide binding]; other site 1031709000867 active site 1031709000868 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1031709000869 catalytic center binding site [active] 1031709000870 ATP binding site [chemical binding]; other site 1031709000871 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1031709000872 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 1031709000873 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 1031709000874 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 1031709000875 Lsr2; Region: Lsr2; pfam11774 1031709000876 Clp protease ATP binding subunit; Region: clpC; CHL00095 1031709000877 Clp amino terminal domain; Region: Clp_N; pfam02861 1031709000878 Clp amino terminal domain; Region: Clp_N; pfam02861 1031709000879 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1031709000880 Walker A motif; other site 1031709000881 ATP binding site [chemical binding]; other site 1031709000882 Walker B motif; other site 1031709000883 arginine finger; other site 1031709000884 UvrB/uvrC motif; Region: UVR; pfam02151 1031709000885 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1031709000886 Walker A motif; other site 1031709000887 ATP binding site [chemical binding]; other site 1031709000888 Walker B motif; other site 1031709000889 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1031709000890 Protein of unknown function (DUF2891); Region: DUF2891; pfam11199 1031709000891 Predicted membrane protein [Function unknown]; Region: COG3817 1031709000892 Protein of unknown function (DUF979); Region: DUF979; pfam06166 1031709000893 Protein of unknown function (DUF969); Region: DUF969; pfam06149 1031709000894 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 1031709000895 putative active site [active] 1031709000896 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 1031709000897 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 1031709000898 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 1031709000899 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1031709000900 putative substrate translocation pore; other site 1031709000901 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1031709000902 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 1031709000903 TIGR01777 family protein; Region: yfcH 1031709000904 putative NAD(P) binding site [chemical binding]; other site 1031709000905 putative active site [active] 1031709000906 Rhomboid family; Region: Rhomboid; pfam01694 1031709000907 hypothetical protein; Provisional; Region: PRK06547 1031709000908 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1031709000909 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1031709000910 active site 1031709000911 phosphorylation site [posttranslational modification] 1031709000912 intermolecular recognition site; other site 1031709000913 dimerization interface [polypeptide binding]; other site 1031709000914 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1031709000915 DNA binding residues [nucleotide binding] 1031709000916 dimerization interface [polypeptide binding]; other site 1031709000917 Histidine kinase; Region: HisKA_3; pfam07730 1031709000918 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1031709000919 ATP binding site [chemical binding]; other site 1031709000920 Mg2+ binding site [ion binding]; other site 1031709000921 G-X-G motif; other site 1031709000922 CAT RNA binding domain; Region: CAT_RBD; smart01061 1031709000923 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1031709000924 PRD domain; Region: PRD; pfam00874 1031709000925 PRD domain; Region: PRD; pfam00874 1031709000926 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1031709000927 HPr interaction site; other site 1031709000928 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1031709000929 active site 1031709000930 phosphorylation site [posttranslational modification] 1031709000931 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 1031709000932 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1031709000933 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1031709000934 active site turn [active] 1031709000935 phosphorylation site [posttranslational modification] 1031709000936 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1031709000937 Putative N-acetylmannosamine-6-phosphate epimerase; Region: NanE; pfam04131 1031709000938 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1031709000939 D-galactonate transporter; Region: 2A0114; TIGR00893 1031709000940 putative substrate translocation pore; other site 1031709000941 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1031709000942 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 1031709000943 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 1031709000944 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1031709000945 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1031709000946 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1031709000947 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1031709000948 endonuclease III; Region: ENDO3c; smart00478 1031709000949 minor groove reading motif; other site 1031709000950 helix-hairpin-helix signature motif; other site 1031709000951 substrate binding pocket [chemical binding]; other site 1031709000952 active site 1031709000953 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1031709000954 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1031709000955 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1031709000956 inhibitor-cofactor binding pocket; inhibition site 1031709000957 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1031709000958 catalytic residue [active] 1031709000959 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1031709000960 dimer interface [polypeptide binding]; other site 1031709000961 active site 1031709000962 Schiff base residues; other site 1031709000963 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 1031709000964 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1031709000965 active site 1031709000966 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1031709000967 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 1031709000968 domain interfaces; other site 1031709000969 active site 1031709000970 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1031709000971 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1031709000972 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1031709000973 substrate binding site [chemical binding]; other site 1031709000974 active site 1031709000975 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1031709000976 Glutamyl-tRNAGlu reductase, N-terminal domain; Region: GlutR_N; pfam05201 1031709000977 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1031709000978 ferrochelatase; Reviewed; Region: hemH; PRK00035 1031709000979 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1031709000980 C-terminal domain interface [polypeptide binding]; other site 1031709000981 active site 1031709000982 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1031709000983 active site 1031709000984 N-terminal domain interface [polypeptide binding]; other site 1031709000985 Chlorite dismutase; Region: Chlor_dismutase; pfam06778 1031709000986 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 1031709000987 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1031709000988 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 1031709000989 DNA repair protein RadA; Provisional; Region: PRK11823 1031709000990 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1031709000991 Walker A motif; other site 1031709000992 ATP binding site [chemical binding]; other site 1031709000993 Walker B motif; other site 1031709000994 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1031709000995 malate dehydrogenase; Provisional; Region: PRK13529 1031709000996 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1031709000997 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1031709000998 NAD(P) binding site [chemical binding]; other site 1031709000999 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 1031709001000 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1031709001001 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1031709001002 AP (apurinic/apyrimidinic) site pocket; other site 1031709001003 DNA interaction; other site 1031709001004 Metal-binding active site; metal-binding site 1031709001005 Proline dehydrogenase; Region: Pro_dh; cl03282 1031709001006 CAAX protease self-immunity; Region: Abi; pfam02517 1031709001007 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1031709001008 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1031709001009 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1031709001010 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1031709001011 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 1031709001012 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 1031709001013 active site 1031709001014 homodimer interface [polypeptide binding]; other site 1031709001015 SAM binding site [chemical binding]; other site 1031709001016 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1031709001017 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1031709001018 active site 1031709001019 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1031709001020 catalytic core [active] 1031709001021 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1031709001022 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1031709001023 catalytic residues [active] 1031709001024 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1031709001025 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1031709001026 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 1031709001027 ResB-like family; Region: ResB; pfam05140 1031709001028 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 1031709001029 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 1031709001030 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1031709001031 Sporulation and spore germination; Region: Germane; pfam10646 1031709001032 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1031709001033 classical (c) SDRs; Region: SDR_c; cd05233 1031709001034 NAD(P) binding site [chemical binding]; other site 1031709001035 active site 1031709001036 mycothione reductase; Reviewed; Region: PRK07846 1031709001037 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1031709001038 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1031709001039 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1031709001040 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1031709001041 intersubunit interface [polypeptide binding]; other site 1031709001042 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1031709001043 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1031709001044 Walker A/P-loop; other site 1031709001045 ATP binding site [chemical binding]; other site 1031709001046 Q-loop/lid; other site 1031709001047 ABC transporter signature motif; other site 1031709001048 Walker B; other site 1031709001049 D-loop; other site 1031709001050 H-loop/switch region; other site 1031709001051 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1031709001052 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1031709001053 ABC-ATPase subunit interface; other site 1031709001054 dimer interface [polypeptide binding]; other site 1031709001055 putative PBP binding regions; other site 1031709001056 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1031709001057 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1031709001058 FAD binding pocket [chemical binding]; other site 1031709001059 FAD binding motif [chemical binding]; other site 1031709001060 phosphate binding motif [ion binding]; other site 1031709001061 NAD binding pocket [chemical binding]; other site 1031709001062 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 1031709001063 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1031709001064 Walker A/P-loop; other site 1031709001065 ATP binding site [chemical binding]; other site 1031709001066 Q-loop/lid; other site 1031709001067 ABC transporter signature motif; other site 1031709001068 Walker B; other site 1031709001069 D-loop; other site 1031709001070 H-loop/switch region; other site 1031709001071 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1031709001072 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1031709001073 dimer interface [polypeptide binding]; other site 1031709001074 conserved gate region; other site 1031709001075 putative PBP binding loops; other site 1031709001076 ABC-ATPase subunit interface; other site 1031709001077 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 1031709001078 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1031709001079 dimer interface [polypeptide binding]; other site 1031709001080 conserved gate region; other site 1031709001081 putative PBP binding loops; other site 1031709001082 ABC-ATPase subunit interface; other site 1031709001083 PBP superfamily domain; Region: PBP_like_2; cl17296 1031709001084 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1031709001085 active site 1031709001086 Ap6A binding site [chemical binding]; other site 1031709001087 nudix motif; other site 1031709001088 metal binding site [ion binding]; metal-binding site 1031709001089 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1031709001090 catalytic core [active] 1031709001091 polyphosphate kinase; Provisional; Region: PRK05443 1031709001092 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1031709001093 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1031709001094 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 1031709001095 putative domain interface [polypeptide binding]; other site 1031709001096 putative active site [active] 1031709001097 catalytic site [active] 1031709001098 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 1031709001099 putative domain interface [polypeptide binding]; other site 1031709001100 putative active site [active] 1031709001101 catalytic site [active] 1031709001102 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1031709001103 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1031709001104 DNA binding site [nucleotide binding] 1031709001105 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1031709001106 putative active site [active] 1031709001107 dimerization interface [polypeptide binding]; other site 1031709001108 putative tRNAtyr binding site [nucleotide binding]; other site 1031709001109 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 1031709001110 heme-binding site [chemical binding]; other site 1031709001111 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 1031709001112 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1031709001113 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1031709001114 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1031709001115 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1031709001116 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1031709001117 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1031709001118 NAD(P) binding site [chemical binding]; other site 1031709001119 active site 1031709001120 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1031709001121 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1031709001122 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1031709001123 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1031709001124 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1031709001125 dimerization domain swap beta strand [polypeptide binding]; other site 1031709001126 regulatory protein interface [polypeptide binding]; other site 1031709001127 active site 1031709001128 regulatory phosphorylation site [posttranslational modification]; other site 1031709001129 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1031709001130 substrate binding site; other site 1031709001131 dimer interface; other site 1031709001132 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cl10030 1031709001133 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829 1031709001134 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 1031709001135 active site 1031709001136 P-loop; other site 1031709001137 phosphorylation site [posttranslational modification] 1031709001138 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 1031709001139 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1031709001140 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1031709001141 active site 1031709001142 phosphorylation site [posttranslational modification] 1031709001143 intermolecular recognition site; other site 1031709001144 dimerization interface [polypeptide binding]; other site 1031709001145 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1031709001146 DNA binding site [nucleotide binding] 1031709001147 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1031709001148 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1031709001149 dimer interface [polypeptide binding]; other site 1031709001150 phosphorylation site [posttranslational modification] 1031709001151 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1031709001152 ATP binding site [chemical binding]; other site 1031709001153 Mg2+ binding site [ion binding]; other site 1031709001154 G-X-G motif; other site 1031709001155 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1031709001156 PhoU domain; Region: PhoU; pfam01895 1031709001157 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1031709001158 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 1031709001159 NodB motif; other site 1031709001160 active site 1031709001161 catalytic site [active] 1031709001162 Zn binding site [ion binding]; other site 1031709001163 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1031709001164 catalytic core [active] 1031709001165 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 1031709001166 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1031709001167 active site 1031709001168 phosphorylation site [posttranslational modification] 1031709001169 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 1031709001170 active site 1031709001171 P-loop; other site 1031709001172 phosphorylation site [posttranslational modification] 1031709001173 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 1031709001174 active site 1031709001175 homodimer interface [polypeptide binding]; other site 1031709001176 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1031709001177 serine hydroxymethyltransferase; Provisional; Region: PRK13580 1031709001178 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1031709001179 dimer interface [polypeptide binding]; other site 1031709001180 active site 1031709001181 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1031709001182 folate binding site [chemical binding]; other site 1031709001183 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1031709001184 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1031709001185 substrate binding site [chemical binding]; other site 1031709001186 ATP binding site [chemical binding]; other site 1031709001187 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1031709001188 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 1031709001189 active site 1031709001190 intersubunit interface [polypeptide binding]; other site 1031709001191 catalytic residue [active] 1031709001192 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745 1031709001193 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1031709001194 NAD(P) binding site [chemical binding]; other site 1031709001195 active site 1031709001196 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 1031709001197 potential frameshift: common BLAST hit: gi|269793985|ref|YP_003313440.1| succinate dehydrogenase/fumarate reductase flavoprotein subunit 1031709001198 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1031709001199 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1031709001200 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 1031709001201 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1031709001202 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1031709001203 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1031709001204 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 1031709001205 substrate binding site [chemical binding]; other site 1031709001206 catalytic residues [active] 1031709001207 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1031709001208 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1031709001209 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1031709001210 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1031709001211 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1031709001212 active site 1031709001213 HIGH motif; other site 1031709001214 nucleotide binding site [chemical binding]; other site 1031709001215 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1031709001216 KMSKS motif; other site 1031709001217 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1031709001218 tRNA binding surface [nucleotide binding]; other site 1031709001219 anticodon binding site; other site 1031709001220 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 1031709001221 Asp23 family; Region: Asp23; pfam03780 1031709001222 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 1031709001223 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1031709001224 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1031709001225 DNA binding residues [nucleotide binding] 1031709001226 Asp23 family; Region: Asp23; cl00574 1031709001227 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1031709001228 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1031709001229 Walker A/P-loop; other site 1031709001230 ATP binding site [chemical binding]; other site 1031709001231 Q-loop/lid; other site 1031709001232 ABC transporter signature motif; other site 1031709001233 Walker B; other site 1031709001234 D-loop; other site 1031709001235 H-loop/switch region; other site 1031709001236 TOBE domain; Region: TOBE_2; pfam08402 1031709001237 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1031709001238 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1031709001239 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1031709001240 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1031709001241 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1031709001242 putative DNA binding site [nucleotide binding]; other site 1031709001243 putative Zn2+ binding site [ion binding]; other site 1031709001244 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1031709001245 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1031709001246 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1031709001247 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1031709001248 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1031709001249 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1031709001250 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1031709001251 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1031709001252 dimer interface [polypeptide binding]; other site 1031709001253 conserved gate region; other site 1031709001254 putative PBP binding loops; other site 1031709001255 ABC-ATPase subunit interface; other site 1031709001256 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1031709001257 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1031709001258 dimer interface [polypeptide binding]; other site 1031709001259 conserved gate region; other site 1031709001260 ABC-ATPase subunit interface; other site 1031709001261 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 1031709001262 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1031709001263 NAD(P) binding site [chemical binding]; other site 1031709001264 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1031709001265 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1031709001266 substrate-cofactor binding pocket; other site 1031709001267 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1031709001268 catalytic residue [active] 1031709001269 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1031709001270 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 1031709001271 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1031709001272 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1031709001273 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1031709001274 Walker A/P-loop; other site 1031709001275 ATP binding site [chemical binding]; other site 1031709001276 Q-loop/lid; other site 1031709001277 ABC transporter signature motif; other site 1031709001278 Walker B; other site 1031709001279 D-loop; other site 1031709001280 H-loop/switch region; other site 1031709001281 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1031709001282 Protein of unknown function, DUF488; Region: DUF488; cl01246 1031709001283 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 1031709001284 putative ADP-ribose binding site [chemical binding]; other site 1031709001285 putative active site [active] 1031709001286 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1031709001287 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1031709001288 NAD(P) binding site [chemical binding]; other site 1031709001289 substrate binding site [chemical binding]; other site 1031709001290 dimer interface [polypeptide binding]; other site 1031709001291 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1031709001292 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1031709001293 Walker A/P-loop; other site 1031709001294 ATP binding site [chemical binding]; other site 1031709001295 Q-loop/lid; other site 1031709001296 ABC transporter signature motif; other site 1031709001297 Walker B; other site 1031709001298 D-loop; other site 1031709001299 H-loop/switch region; other site 1031709001300 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1031709001301 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1031709001302 Histidine kinase; Region: HisKA_3; pfam07730 1031709001303 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1031709001304 ATP binding site [chemical binding]; other site 1031709001305 Mg2+ binding site [ion binding]; other site 1031709001306 G-X-G motif; other site 1031709001307 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1031709001308 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1031709001309 active site 1031709001310 phosphorylation site [posttranslational modification] 1031709001311 intermolecular recognition site; other site 1031709001312 dimerization interface [polypeptide binding]; other site 1031709001313 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1031709001314 DNA binding residues [nucleotide binding] 1031709001315 dimerization interface [polypeptide binding]; other site 1031709001316 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1031709001317 catalytic core [active] 1031709001318 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 1031709001319 cobyric acid synthase; Provisional; Region: PRK00784 1031709001320 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1031709001321 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1031709001322 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1031709001323 catalytic triad [active] 1031709001324 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 1031709001325 active site 1031709001326 SAM binding site [chemical binding]; other site 1031709001327 homodimer interface [polypeptide binding]; other site 1031709001328 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 1031709001329 active site 1031709001330 SAM binding site [chemical binding]; other site 1031709001331 homodimer interface [polypeptide binding]; other site 1031709001332 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 1031709001333 putative homodimer interface [polypeptide binding]; other site 1031709001334 active site 1031709001335 SAM binding site [chemical binding]; other site 1031709001336 Cobalamin biosynthesis protein CbiG [Coenzyme metabolism]; Region: CbiG; COG2073 1031709001337 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 1031709001338 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 1031709001339 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 1031709001340 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 1031709001341 active site 1031709001342 SAM binding site [chemical binding]; other site 1031709001343 homodimer interface [polypeptide binding]; other site 1031709001344 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1031709001345 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1031709001346 putative active site [active] 1031709001347 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 1031709001348 putative active site [active] 1031709001349 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 1031709001350 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1031709001351 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1031709001352 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1031709001353 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1031709001354 putative PBP binding regions; other site 1031709001355 ABC-ATPase subunit interface; other site 1031709001356 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1031709001357 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1031709001358 Walker A/P-loop; other site 1031709001359 ATP binding site [chemical binding]; other site 1031709001360 Q-loop/lid; other site 1031709001361 ABC transporter signature motif; other site 1031709001362 Walker B; other site 1031709001363 D-loop; other site 1031709001364 H-loop/switch region; other site 1031709001365 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1031709001366 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 1031709001367 intersubunit interface [polypeptide binding]; other site 1031709001368 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 1031709001369 AAA domain; Region: AAA_14; pfam13173 1031709001370 Nuclease-related domain; Region: NERD; pfam08378 1031709001371 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 1031709001372 Precorrin-8X methylmutase; Region: CbiC; pfam02570 1031709001373 cobalt transport protein CbiM; Validated; Region: PRK08319 1031709001374 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 1031709001375 cobalt transport protein CbiN; Provisional; Region: PRK02898 1031709001376 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 1031709001377 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1031709001378 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 1031709001379 Walker A/P-loop; other site 1031709001380 ATP binding site [chemical binding]; other site 1031709001381 Q-loop/lid; other site 1031709001382 ABC transporter signature motif; other site 1031709001383 Walker B; other site 1031709001384 D-loop; other site 1031709001385 H-loop/switch region; other site 1031709001386 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 1031709001387 Methyltransferase domain; Region: Methyltransf_18; pfam12847 1031709001388 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 1031709001389 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 1031709001390 homodimer interface [polypeptide binding]; other site 1031709001391 Walker A motif; other site 1031709001392 ATP binding site [chemical binding]; other site 1031709001393 hydroxycobalamin binding site [chemical binding]; other site 1031709001394 Walker B motif; other site 1031709001395 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 1031709001396 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 1031709001397 catalytic triad [active] 1031709001398 hypothetical protein; Provisional; Region: PRK07908 1031709001399 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1031709001400 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1031709001401 homodimer interface [polypeptide binding]; other site 1031709001402 catalytic residue [active] 1031709001403 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1031709001404 homodimer interface [polypeptide binding]; other site 1031709001405 active site 1031709001406 SAM binding site [chemical binding]; other site 1031709001407 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 1031709001408 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 1031709001409 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 1031709001410 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1031709001411 putative dimer interface [polypeptide binding]; other site 1031709001412 active site pocket [active] 1031709001413 putative cataytic base [active] 1031709001414 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 1031709001415 homotrimer interface [polypeptide binding]; other site 1031709001416 Walker A motif; other site 1031709001417 GTP binding site [chemical binding]; other site 1031709001418 Walker B motif; other site 1031709001419 cobalamin synthase; Reviewed; Region: cobS; PRK00235 1031709001420 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1031709001421 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1031709001422 intersubunit interface [polypeptide binding]; other site 1031709001423 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 1031709001424 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1031709001425 active site 1031709001426 phosphorylation site [posttranslational modification] 1031709001427 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 1031709001428 active site 1031709001429 P-loop; other site 1031709001430 phosphorylation site [posttranslational modification] 1031709001431 S-Ribosylhomocysteinase (LuxS); Region: LuxS; cl00802 1031709001432 S-ribosylhomocysteinase; Provisional; Region: PRK02260 1031709001433 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 1031709001434 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1031709001435 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1031709001436 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 1031709001437 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1031709001438 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1031709001439 ring oligomerisation interface [polypeptide binding]; other site 1031709001440 ATP/Mg binding site [chemical binding]; other site 1031709001441 stacking interactions; other site 1031709001442 hinge regions; other site 1031709001443 Transaldolase; Region: Transaldolase; pfam00923 1031709001444 catalytic residue [active] 1031709001445 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1031709001446 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1031709001447 DNA-binding site [nucleotide binding]; DNA binding site 1031709001448 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1031709001449 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1031709001450 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1031709001451 substrate binding site [chemical binding]; other site 1031709001452 ATP binding site [chemical binding]; other site 1031709001453 KduI/IolB family; Region: KduI; pfam04962 1031709001454 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 1031709001455 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1031709001456 PYR/PP interface [polypeptide binding]; other site 1031709001457 dimer interface [polypeptide binding]; other site 1031709001458 TPP binding site [chemical binding]; other site 1031709001459 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cd00368 1031709001460 molybdopterin cofactor binding site; other site 1031709001461 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 1031709001462 TPP-binding site; other site 1031709001463 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1031709001464 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1031709001465 tetrameric interface [polypeptide binding]; other site 1031709001466 NAD binding site [chemical binding]; other site 1031709001467 catalytic residues [active] 1031709001468 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1031709001469 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1031709001470 DNA binding site [nucleotide binding] 1031709001471 domain linker motif; other site 1031709001472 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1031709001473 dimerization interface [polypeptide binding]; other site 1031709001474 ligand binding site [chemical binding]; other site 1031709001475 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1031709001476 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1031709001477 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1031709001478 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1031709001479 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1031709001480 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1031709001481 AP (apurinic/apyrimidinic) site pocket; other site 1031709001482 DNA interaction; other site 1031709001483 Metal-binding active site; metal-binding site 1031709001484 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1031709001485 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1031709001486 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1031709001487 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 1031709001488 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1031709001489 putative substrate translocation pore; other site 1031709001490 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1031709001491 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1031709001492 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1031709001493 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1031709001494 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1031709001495 DNA interaction; other site 1031709001496 Metal-binding active site; metal-binding site 1031709001497 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1031709001498 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1031709001499 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1031709001500 CAAX protease self-immunity; Region: Abi; pfam02517 1031709001501 CutC family; Region: CutC; cl01218 1031709001502 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1031709001503 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1031709001504 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1031709001505 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1031709001506 ATP binding site [chemical binding]; other site 1031709001507 putative Mg++ binding site [ion binding]; other site 1031709001508 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1031709001509 nucleotide binding region [chemical binding]; other site 1031709001510 ATP-binding site [chemical binding]; other site 1031709001511 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1031709001512 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1031709001513 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1031709001514 active site 1031709001515 trimer interface [polypeptide binding]; other site 1031709001516 allosteric site; other site 1031709001517 active site lid [active] 1031709001518 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1031709001519 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1031709001520 DNA-binding site [nucleotide binding]; DNA binding site 1031709001521 RNA-binding motif; other site 1031709001522 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 1031709001523 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1031709001524 phosphoserine aminotransferase; Provisional; Region: PRK03080 1031709001525 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1031709001526 catalytic residue [active] 1031709001527 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1031709001528 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1031709001529 active site 1031709001530 dimer interface [polypeptide binding]; other site 1031709001531 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1031709001532 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 1031709001533 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1031709001534 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1031709001535 catalytic residues [active] 1031709001536 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1031709001537 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1031709001538 putative substrate translocation pore; other site 1031709001539 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1031709001540 Eukaryotic UGPase catalyses the synthesis of UDP-Glucose; Region: UGPase_euk; cd00897 1031709001541 active site 1031709001542 substrate binding site; other site 1031709001543 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 1031709001544 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1031709001545 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1031709001546 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 1031709001547 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1031709001548 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 1031709001549 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1031709001550 dimer interface [polypeptide binding]; other site 1031709001551 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1031709001552 putative MPT binding site; other site 1031709001553 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1031709001554 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1031709001555 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 1031709001556 MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor...; Region: MoaC; cl00242 1031709001557 trimer interface [polypeptide binding]; other site 1031709001558 dimer interface [polypeptide binding]; other site 1031709001559 putative active site [active] 1031709001560 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1031709001561 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1031709001562 dimer interface [polypeptide binding]; other site 1031709001563 putative functional site; other site 1031709001564 putative MPT binding site; other site 1031709001565 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1031709001566 MoaE homodimer interface [polypeptide binding]; other site 1031709001567 MoaD interaction [polypeptide binding]; other site 1031709001568 active site residues [active] 1031709001569 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1031709001570 MoaE interaction surface [polypeptide binding]; other site 1031709001571 MoeB interaction surface [polypeptide binding]; other site 1031709001572 thiocarboxylated glycine; other site 1031709001573 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 1031709001574 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1031709001575 FeS/SAM binding site; other site 1031709001576 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1031709001577 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 1031709001578 DNA binding residues [nucleotide binding] 1031709001579 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 1031709001580 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1031709001581 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1031709001582 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1031709001583 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1031709001584 dimer interface [polypeptide binding]; other site 1031709001585 conserved gate region; other site 1031709001586 putative PBP binding loops; other site 1031709001587 ABC-ATPase subunit interface; other site 1031709001588 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 1031709001589 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1031709001590 Walker A/P-loop; other site 1031709001591 ATP binding site [chemical binding]; other site 1031709001592 Q-loop/lid; other site 1031709001593 ABC transporter signature motif; other site 1031709001594 Walker B; other site 1031709001595 D-loop; other site 1031709001596 H-loop/switch region; other site 1031709001597 Predicted transcriptional regulator [Transcription]; Region: COG2345 1031709001598 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 1031709001599 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 1031709001600 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 1031709001601 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1031709001602 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 1031709001603 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1031709001604 [4Fe-4S] binding site [ion binding]; other site 1031709001605 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1031709001606 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1031709001607 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1031709001608 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1031709001609 molybdopterin cofactor binding site; other site 1031709001610 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1031709001611 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1031709001612 putative substrate translocation pore; other site 1031709001613 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1031709001614 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1031709001615 GTP binding site; other site 1031709001616 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1031709001617 MPT binding site; other site 1031709001618 trimer interface [polypeptide binding]; other site 1031709001619 DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519 1031709001620 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 1031709001621 4Fe-4S binding domain; Region: Fer4; pfam00037 1031709001622 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 1031709001623 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 1031709001624 putative [Fe4-S4] binding site [ion binding]; other site 1031709001625 putative molybdopterin cofactor binding site [chemical binding]; other site 1031709001626 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 1031709001627 putative molybdopterin cofactor binding site; other site 1031709001628 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 1031709001629 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1031709001630 ATP binding site [chemical binding]; other site 1031709001631 substrate interface [chemical binding]; other site 1031709001632 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1031709001633 ThiS interaction site; other site 1031709001634 putative active site [active] 1031709001635 tetramer interface [polypeptide binding]; other site 1031709001636 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1031709001637 thiS-thiF/thiG interaction site; other site 1031709001638 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1031709001639 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1031709001640 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 1031709001641 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 1031709001642 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 1031709001643 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1031709001644 Predicted methyltransferases [General function prediction only]; Region: COG0313 1031709001645 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1031709001646 putative SAM binding site [chemical binding]; other site 1031709001647 putative homodimer interface [polypeptide binding]; other site 1031709001648 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1031709001649 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1031709001650 active site 1031709001651 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1031709001652 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 1031709001653 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 1031709001654 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1031709001655 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1031709001656 MarR family; Region: MarR_2; cl17246 1031709001657 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1031709001658 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1031709001659 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14360 1031709001660 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1031709001661 Substrate binding site; other site 1031709001662 Mg++ binding site; other site 1031709001663 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1031709001664 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1031709001665 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 1031709001666 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1031709001667 active site 1031709001668 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1031709001669 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1031709001670 5S rRNA interface [nucleotide binding]; other site 1031709001671 CTC domain interface [polypeptide binding]; other site 1031709001672 L16 interface [polypeptide binding]; other site 1031709001673 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1031709001674 putative active site [active] 1031709001675 catalytic residue [active] 1031709001676 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1031709001677 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1031709001678 NAD binding site [chemical binding]; other site 1031709001679 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1031709001680 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH6; cd08260 1031709001681 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1031709001682 putative NAD(P) binding site [chemical binding]; other site 1031709001683 catalytic Zn binding site [ion binding]; other site 1031709001684 structural Zn binding site [ion binding]; other site 1031709001685 Protease prsW family; Region: PrsW-protease; pfam13367 1031709001686 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1031709001687 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1031709001688 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1031709001689 ATP binding site [chemical binding]; other site 1031709001690 putative Mg++ binding site [ion binding]; other site 1031709001691 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1031709001692 nucleotide binding region [chemical binding]; other site 1031709001693 ATP-binding site [chemical binding]; other site 1031709001694 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1031709001695 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1031709001696 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12333 1031709001697 homodimer interface [polypeptide binding]; other site 1031709001698 metal binding site [ion binding]; metal-binding site 1031709001699 enolase; Provisional; Region: eno; PRK00077 1031709001700 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1031709001701 dimer interface [polypeptide binding]; other site 1031709001702 metal binding site [ion binding]; metal-binding site 1031709001703 substrate binding pocket [chemical binding]; other site 1031709001704 Septum formation initiator; Region: DivIC; pfam04977 1031709001705 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1031709001706 Protein of unknown function (DUF501); Region: DUF501; pfam04417 1031709001707 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1031709001708 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1031709001709 Bax inhibitor 1 like; Region: BaxI_1; cl17691 1031709001710 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 1031709001711 nudix motif; other site 1031709001712 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1031709001713 Coenzyme A binding pocket [chemical binding]; other site 1031709001714 Predicted membrane protein [Function unknown]; Region: COG2246 1031709001715 GtrA-like protein; Region: GtrA; pfam04138 1031709001716 Predicted membrane protein [Function unknown]; Region: COG1297 1031709001717 putative oligopeptide transporter, OPT family; Region: TIGR00733 1031709001718 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1031709001719 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1031709001720 active site 1031709001721 catalytic tetrad [active] 1031709001722 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 1031709001723 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 1031709001724 Na2 binding site [ion binding]; other site 1031709001725 putative substrate binding site 1 [chemical binding]; other site 1031709001726 Na binding site 1 [ion binding]; other site 1031709001727 putative substrate binding site 2 [chemical binding]; other site 1031709001728 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1031709001729 ligand binding site [chemical binding]; other site 1031709001730 active site 1031709001731 UGI interface [polypeptide binding]; other site 1031709001732 catalytic site [active] 1031709001733 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1031709001734 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1031709001735 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1031709001736 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1031709001737 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1031709001738 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 1031709001739 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 1031709001740 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 1031709001741 catalytic residues [active] 1031709001742 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 1031709001743 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 1031709001744 catalytic residue [active] 1031709001745 putative FPP diphosphate binding site; other site 1031709001746 putative FPP binding hydrophobic cleft; other site 1031709001747 dimer interface [polypeptide binding]; other site 1031709001748 putative IPP diphosphate binding site; other site 1031709001749 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1031709001750 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1031709001751 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 1031709001752 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 1031709001753 putative active site [active] 1031709001754 PhoH-like protein; Region: PhoH; pfam02562 1031709001755 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 1031709001756 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1031709001757 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1031709001758 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1031709001759 generic binding surface II; other site 1031709001760 generic binding surface I; other site 1031709001761 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 1031709001762 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1031709001763 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1031709001764 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1031709001765 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1031709001766 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1031709001767 RmuC family; Region: RmuC; pfam02646 1031709001768 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 1031709001769 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 1031709001770 active site 1031709001771 metal binding site [ion binding]; metal-binding site 1031709001772 GTP-binding protein YchF; Reviewed; Region: PRK09601 1031709001773 YchF GTPase; Region: YchF; cd01900 1031709001774 G1 box; other site 1031709001775 GTP/Mg2+ binding site [chemical binding]; other site 1031709001776 Switch I region; other site 1031709001777 G2 box; other site 1031709001778 Switch II region; other site 1031709001779 G3 box; other site 1031709001780 G4 box; other site 1031709001781 G5 box; other site 1031709001782 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1031709001783 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1031709001784 putative substrate translocation pore; other site 1031709001785 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1031709001786 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1031709001787 MarR family; Region: MarR; pfam01047 1031709001788 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1031709001789 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 1031709001790 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1031709001791 potential catalytic triad [active] 1031709001792 conserved cys residue [active] 1031709001793 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 1031709001794 Spore germination protein; Region: Spore_permease; cl17796 1031709001795 arginine deiminase; Provisional; Region: PRK01388 1031709001796 ornithine carbamoyltransferase; Validated; Region: PRK02102 1031709001797 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1031709001798 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1031709001799 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 1031709001800 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1031709001801 putative substrate binding site [chemical binding]; other site 1031709001802 nucleotide binding site [chemical binding]; other site 1031709001803 nucleotide binding site [chemical binding]; other site 1031709001804 homodimer interface [polypeptide binding]; other site 1031709001805 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1031709001806 Peptidyl-tRNA hydrolase, type 2 (PTH2)_like . Peptidyl-tRNA hydrolase activity releases tRNA from the premature translation termination product peptidyl-tRNA. Two structurally different enzymes have been reported to encode such activity, Pth present in...; Region: PTH2_family; cl00869 1031709001807 dimer interface [polypeptide binding]; other site 1031709001808 putative active site [active] 1031709001809 ACT domain; Region: ACT_6; pfam13740 1031709001810 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 1031709001811 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869 1031709001812 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1031709001813 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1031709001814 active site 1031709001815 catalytic tetrad [active] 1031709001816 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1031709001817 dimer interface [polypeptide binding]; other site 1031709001818 catalytic triad [active] 1031709001819 peroxidatic and resolving cysteines [active] 1031709001820 lysine transporter; Provisional; Region: PRK10836 1031709001821 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like; cd11354 1031709001822 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1031709001823 active site 1031709001824 catalytic site [active] 1031709001825 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 1031709001826 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1031709001827 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1031709001828 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1031709001829 monoglyceride lipase; Provisional; Region: PHA02857 1031709001830 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1031709001831 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 1031709001832 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 1031709001833 heterodimer interface [polypeptide binding]; other site 1031709001834 substrate interaction site [chemical binding]; other site 1031709001835 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 1031709001836 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 1031709001837 active site 1031709001838 substrate binding site [chemical binding]; other site 1031709001839 coenzyme B12 binding site [chemical binding]; other site 1031709001840 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 1031709001841 B12 binding site [chemical binding]; other site 1031709001842 cobalt ligand [ion binding]; other site 1031709001843 membrane ATPase/protein kinase; Provisional; Region: PRK09435 1031709001844 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 1031709001845 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 1031709001846 Walker A; other site 1031709001847 G1 box; other site 1031709001848 GTP/Mg2+ binding site [chemical binding]; other site 1031709001849 Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496 1031709001850 active site 1031709001851 catalytic triad [active] 1031709001852 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1031709001853 RNA binding surface [nucleotide binding]; other site 1031709001854 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1031709001855 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1031709001856 Walker A/P-loop; other site 1031709001857 ATP binding site [chemical binding]; other site 1031709001858 Q-loop/lid; other site 1031709001859 ABC transporter signature motif; other site 1031709001860 Walker B; other site 1031709001861 D-loop; other site 1031709001862 H-loop/switch region; other site 1031709001863 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1031709001864 dimer interface [polypeptide binding]; other site 1031709001865 ABC-ATPase subunit interface; other site 1031709001866 putative PBP binding loops; other site 1031709001867 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1031709001868 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1031709001869 DNA binding site [nucleotide binding] 1031709001870 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 1031709001871 ligand binding site [chemical binding]; other site 1031709001872 dimerization interface (open form) [polypeptide binding]; other site 1031709001873 dimerization interface (closed form) [polypeptide binding]; other site 1031709001874 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1031709001875 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1031709001876 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 1031709001877 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 1031709001878 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1031709001879 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1031709001880 dimer interface [polypeptide binding]; other site 1031709001881 conserved gate region; other site 1031709001882 putative PBP binding loops; other site 1031709001883 ABC-ATPase subunit interface; other site 1031709001884 Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812 1031709001885 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 1031709001886 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 1031709001887 trimer interface [polypeptide binding]; other site 1031709001888 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1031709001889 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 1031709001890 substrate binding site [chemical binding]; other site 1031709001891 Mn binding site [ion binding]; other site 1031709001892 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 1031709001893 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1031709001894 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1031709001895 Walker A/P-loop; other site 1031709001896 ATP binding site [chemical binding]; other site 1031709001897 Q-loop/lid; other site 1031709001898 ABC transporter signature motif; other site 1031709001899 Walker B; other site 1031709001900 D-loop; other site 1031709001901 H-loop/switch region; other site 1031709001902 FtsX-like permease family; Region: FtsX; pfam02687 1031709001903 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1031709001904 dimer interface [polypeptide binding]; other site 1031709001905 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1031709001906 putative PBP binding regions; other site 1031709001907 ABC-ATPase subunit interface; other site 1031709001908 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1031709001909 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1031709001910 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1031709001911 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1031709001912 intersubunit interface [polypeptide binding]; other site 1031709001913 Isochorismatase family; Region: Isochorismatase; pfam00857 1031709001914 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1031709001915 catalytic triad [active] 1031709001916 conserved cis-peptide bond; other site 1031709001917 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1031709001918 Na binding site [ion binding]; other site 1031709001919 Proline dehydrogenase; Region: Pro_dh; cl03282 1031709001920 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 1031709001921 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1031709001922 Glutamate binding site [chemical binding]; other site 1031709001923 NAD binding site [chemical binding]; other site 1031709001924 catalytic residues [active] 1031709001925 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1031709001926 L-iditol 2-dehydrogenase; Region: iditol_2_DH_like; cd08235 1031709001927 putative NAD(P) binding site [chemical binding]; other site 1031709001928 catalytic Zn binding site [ion binding]; other site 1031709001929 dihydroxyacetone kinase; Provisional; Region: PRK14479 1031709001930 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 1031709001931 DAK2 domain; Region: Dak2; pfam02734 1031709001932 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 1031709001933 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1031709001934 active site 1031709001935 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1031709001936 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1031709001937 Coenzyme A binding pocket [chemical binding]; other site 1031709001938 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1031709001939 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 1031709001940 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 1031709001941 ligand binding site [chemical binding]; other site 1031709001942 homodimer interface [polypeptide binding]; other site 1031709001943 NAD(P) binding site [chemical binding]; other site 1031709001944 trimer interface B [polypeptide binding]; other site 1031709001945 trimer interface A [polypeptide binding]; other site 1031709001946 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 1031709001947 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 1031709001948 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 1031709001949 Ferredoxin [Energy production and conversion]; Region: COG1146 1031709001950 4Fe-4S binding domain; Region: Fer4; pfam00037 1031709001951 succinyldiaminopimelate transaminase; Region: DapC_actino; TIGR03539 1031709001952 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1031709001953 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1031709001954 homodimer interface [polypeptide binding]; other site 1031709001955 catalytic residue [active] 1031709001956 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 1031709001957 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 1031709001958 putative trimer interface [polypeptide binding]; other site 1031709001959 putative CoA binding site [chemical binding]; other site 1031709001960 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 1031709001961 Amidinotransferase; Region: Amidinotransf; cl12043 1031709001962 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1031709001963 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1031709001964 metabolite-proton symporter; Region: 2A0106; TIGR00883 1031709001965 putative substrate translocation pore; other site 1031709001966 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 1031709001967 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 1031709001968 metal binding site [ion binding]; metal-binding site 1031709001969 putative dimer interface [polypeptide binding]; other site 1031709001970 DivIVA domain; Region: DivI1A_domain; TIGR03544 1031709001971 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 1031709001972 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 1031709001973 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1031709001974 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 1031709001975 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1031709001976 ligand binding site; other site 1031709001977 oligomer interface; other site 1031709001978 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1031709001979 dimer interface [polypeptide binding]; other site 1031709001980 N-terminal domain interface [polypeptide binding]; other site 1031709001981 sulfate 1 binding site; other site 1031709001982 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1031709001983 S-adenosylmethionine binding site [chemical binding]; other site 1031709001984 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1031709001985 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1031709001986 dimer interface [polypeptide binding]; other site 1031709001987 active site 1031709001988 catalytic residue [active] 1031709001989 sec-independent translocase; Provisional; Region: PRK01371 1031709001990 Domain of unknown function DUF59; Region: DUF59; cl00941 1031709001991 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1031709001992 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1031709001993 Walker A motif; other site 1031709001994 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 1031709001995 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1031709001996 MgtE intracellular N domain; Region: MgtE_N; smart00924 1031709001997 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1031709001998 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1031709001999 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 1031709002000 proline aminopeptidase P II; Provisional; Region: PRK10879 1031709002001 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1031709002002 active site 1031709002003 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 1031709002004 Putative zinc ribbon domain; Region: DUF164; pfam02591 1031709002005 YcfA-like protein; Region: YcfA; cl00752 1031709002006 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 1031709002007 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1031709002008 intersubunit interface [polypeptide binding]; other site 1031709002009 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1031709002010 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1031709002011 ABC-ATPase subunit interface; other site 1031709002012 dimer interface [polypeptide binding]; other site 1031709002013 putative PBP binding regions; other site 1031709002014 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1031709002015 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1031709002016 Walker A/P-loop; other site 1031709002017 ATP binding site [chemical binding]; other site 1031709002018 Q-loop/lid; other site 1031709002019 ABC transporter signature motif; other site 1031709002020 Walker B; other site 1031709002021 D-loop; other site 1031709002022 H-loop/switch region; other site 1031709002023 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 1031709002024 dimer interface [polypeptide binding]; other site 1031709002025 [2Fe-2S] cluster binding site [ion binding]; other site 1031709002026 Protein of unknown function (DUF466); Region: DUF466; cl01082 1031709002027 carbon starvation protein A; Provisional; Region: PRK15015 1031709002028 Carbon starvation protein CstA; Region: CstA; pfam02554 1031709002029 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1031709002030 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 1031709002031 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1031709002032 active site 1031709002033 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 1031709002034 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1031709002035 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1031709002036 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1031709002037 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 1031709002038 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1031709002039 metal binding triad; other site 1031709002040 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1031709002041 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1031709002042 metal binding triad; other site 1031709002043 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1031709002044 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1031709002045 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 1031709002046 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1031709002047 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1031709002048 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1031709002049 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1031709002050 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1031709002051 putative active site [active] 1031709002052 glutamine synthetase, type I; Region: GlnA; TIGR00653 1031709002053 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1031709002054 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1031709002055 RDD family; Region: RDD; pfam06271 1031709002056 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1031709002057 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 1031709002058 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1031709002059 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1031709002060 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1031709002061 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 1031709002062 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1031709002063 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1031709002064 DNA-binding site [nucleotide binding]; DNA binding site 1031709002065 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1031709002066 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1031709002067 active site turn [active] 1031709002068 phosphorylation site [posttranslational modification] 1031709002069 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1031709002070 active site turn [active] 1031709002071 phosphorylation site [posttranslational modification] 1031709002072 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1031709002073 HPr interaction site; other site 1031709002074 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1031709002075 active site 1031709002076 phosphorylation site [posttranslational modification] 1031709002077 Protein of unknown function (DUF1440); Region: DUF1440; pfam07274 1031709002078 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 1031709002079 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1031709002080 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1031709002081 ABC transporter; Region: ABC_tran_2; pfam12848 1031709002082 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1031709002083 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 1031709002084 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 1031709002085 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 1031709002086 Asp-box motif; other site 1031709002087 catalytic site [active] 1031709002088 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1031709002089 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 1031709002090 Asp-box motif; other site 1031709002091 catalytic site [active] 1031709002092 putative sialic acid transporter; Provisional; Region: PRK03893 1031709002093 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1031709002094 putative substrate translocation pore; other site 1031709002095 CAMP factor (Cfa); Region: CAMP_factor; pfam07373 1031709002096 lipoyl synthase; Provisional; Region: PRK05481 1031709002097 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1031709002098 FeS/SAM binding site; other site 1031709002099 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1031709002100 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1031709002101 metal-binding site [ion binding] 1031709002102 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1031709002103 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1031709002104 motif II; other site 1031709002105 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 1031709002106 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1031709002107 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1031709002108 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1031709002109 E3 interaction surface; other site 1031709002110 lipoyl attachment site [posttranslational modification]; other site 1031709002111 e3 binding domain; Region: E3_binding; pfam02817 1031709002112 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1031709002113 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1031709002114 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1031709002115 interface (dimer of trimers) [polypeptide binding]; other site 1031709002116 Substrate-binding/catalytic site; other site 1031709002117 Zn-binding sites [ion binding]; other site 1031709002118 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 1031709002119 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1031709002120 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 1031709002121 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 1031709002122 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1031709002123 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1031709002124 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1031709002125 D-pathway; other site 1031709002126 Putative ubiquinol binding site [chemical binding]; other site 1031709002127 Low-spin heme (heme b) binding site [chemical binding]; other site 1031709002128 Putative water exit pathway; other site 1031709002129 Binuclear center (heme o3/CuB) [ion binding]; other site 1031709002130 K-pathway; other site 1031709002131 Putative proton exit pathway; other site 1031709002132 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 1031709002133 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1031709002134 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1031709002135 Walker A/P-loop; other site 1031709002136 ATP binding site [chemical binding]; other site 1031709002137 Q-loop/lid; other site 1031709002138 ABC transporter signature motif; other site 1031709002139 Walker B; other site 1031709002140 D-loop; other site 1031709002141 H-loop/switch region; other site 1031709002142 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1031709002143 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1031709002144 NAD(P) binding site [chemical binding]; other site 1031709002145 active site 1031709002146 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 1031709002147 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1031709002148 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1031709002149 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1031709002150 phosphate binding site [ion binding]; other site 1031709002151 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1031709002152 active site 1031709002153 DNA binding site [nucleotide binding] 1031709002154 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1031709002155 heme bL binding site [chemical binding]; other site 1031709002156 interchain domain interface [polypeptide binding]; other site 1031709002157 intrachain domain interface; other site 1031709002158 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 1031709002159 heme bH binding site [chemical binding]; other site 1031709002160 Qo binding site; other site 1031709002161 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1031709002162 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1031709002163 iron-sulfur cluster [ion binding]; other site 1031709002164 [2Fe-2S] cluster binding site [ion binding]; other site 1031709002165 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1031709002166 Cytochrome c; Region: Cytochrom_C; pfam00034 1031709002167 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1031709002168 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1031709002169 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 1031709002170 Subunit I/III interface [polypeptide binding]; other site 1031709002171 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1031709002172 active site 1031709002173 phosphorylation site [posttranslational modification] 1031709002174 intermolecular recognition site; other site 1031709002175 dimerization interface [polypeptide binding]; other site 1031709002176 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1031709002177 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304 1031709002178 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 1031709002179 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1031709002180 active site 1031709002181 Rhomboid family; Region: Rhomboid; cl11446 1031709002182 hypothetical protein; Validated; Region: PRK07883 1031709002183 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1031709002184 active site 1031709002185 catalytic site [active] 1031709002186 substrate binding site [chemical binding]; other site 1031709002187 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1031709002188 GIY-YIG motif/motif A; other site 1031709002189 active site 1031709002190 catalytic site [active] 1031709002191 putative DNA binding site [nucleotide binding]; other site 1031709002192 metal binding site [ion binding]; metal-binding site 1031709002193 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1031709002194 NlpC/P60 family; Region: NLPC_P60; pfam00877 1031709002195 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 1031709002196 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1031709002197 nucleotide binding site [chemical binding]; other site 1031709002198 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1031709002199 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1031709002200 putative acyl-acceptor binding pocket; other site 1031709002201 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 1031709002202 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 1031709002203 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 1031709002204 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1031709002205 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1031709002206 EamA-like transporter family; Region: EamA; pfam00892 1031709002207 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1031709002208 EamA-like transporter family; Region: EamA; pfam00892 1031709002209 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1031709002210 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1031709002211 active site 1031709002212 ATP binding site [chemical binding]; other site 1031709002213 substrate binding site [chemical binding]; other site 1031709002214 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1031709002215 substrate binding site [chemical binding]; other site 1031709002216 activation loop (A-loop); other site 1031709002217 activation loop (A-loop); other site 1031709002218 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607 1031709002219 active site 1031709002220 barstar interaction site; other site 1031709002221 Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141 1031709002222 putative RNAase interaction site [polypeptide binding]; other site 1031709002223 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1031709002224 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1031709002225 substrate binding pocket [chemical binding]; other site 1031709002226 chain length determination region; other site 1031709002227 substrate-Mg2+ binding site; other site 1031709002228 catalytic residues [active] 1031709002229 aspartate-rich region 1; other site 1031709002230 active site lid residues [active] 1031709002231 aspartate-rich region 2; other site 1031709002232 potential frameshift: common BLAST hit: gi|297626727|ref|YP_003688490.1| 5,10-methylenetetrahydrofolate reductase 1031709002233 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246 1031709002234 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246 1031709002235 Part of AAA domain; Region: AAA_19; pfam13245 1031709002236 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1031709002237 Family description; Region: UvrD_C_2; pfam13538 1031709002238 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1031709002239 catalytic site [active] 1031709002240 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1031709002241 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1031709002242 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1031709002243 putative dimer interface [polypeptide binding]; other site 1031709002244 GntP family permease; Region: GntP_permease; pfam02447 1031709002245 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1031709002246 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1031709002247 ATP-binding site [chemical binding]; other site 1031709002248 Gluconate-6-phosphate binding site [chemical binding]; other site 1031709002249 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1031709002250 DNA-binding site [nucleotide binding]; DNA binding site 1031709002251 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1031709002252 FCD domain; Region: FCD; pfam07729 1031709002253 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1031709002254 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1031709002255 DNA-binding site [nucleotide binding]; DNA binding site 1031709002256 FCD domain; Region: FCD; pfam07729 1031709002257 glycine dehydrogenase; Provisional; Region: PRK05367 1031709002258 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1031709002259 tetramer interface [polypeptide binding]; other site 1031709002260 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1031709002261 catalytic residue [active] 1031709002262 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1031709002263 tetramer interface [polypeptide binding]; other site 1031709002264 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1031709002265 catalytic residue [active] 1031709002266 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1031709002267 lipoyl attachment site [posttranslational modification]; other site 1031709002268 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1031709002269 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 1031709002270 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1031709002271 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1031709002272 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1031709002273 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1031709002274 Protein of unknown function DUF58; Region: DUF58; pfam01882 1031709002275 MoxR-like ATPases [General function prediction only]; Region: COG0714 1031709002276 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1031709002277 ATP binding site [chemical binding]; other site 1031709002278 Walker A motif; other site 1031709002279 Walker B motif; other site 1031709002280 arginine finger; other site 1031709002281 cell division protein MraZ; Reviewed; Region: PRK00326 1031709002282 MraZ protein; Region: MraZ; pfam02381 1031709002283 MraZ protein; Region: MraZ; pfam02381 1031709002284 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1031709002285 MraW methylase family; Region: Methyltransf_5; cl17771 1031709002286 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1031709002287 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 1031709002288 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1031709002289 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1031709002290 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1031709002291 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1031709002292 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1031709002293 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1031709002294 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1031709002295 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1031709002296 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1031709002297 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1031709002298 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1031709002299 Mg++ binding site [ion binding]; other site 1031709002300 putative catalytic motif [active] 1031709002301 putative substrate binding site [chemical binding]; other site 1031709002302 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438 1031709002303 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1031709002304 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1031709002305 cell division protein FtsW; Region: ftsW; TIGR02614 1031709002306 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1031709002307 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1031709002308 active site 1031709002309 homodimer interface [polypeptide binding]; other site 1031709002310 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1031709002311 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1031709002312 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1031709002313 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1031709002314 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1031709002315 Cell division protein FtsQ; Region: FtsQ; pfam03799 1031709002316 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 1031709002317 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1031709002318 nucleotide binding site [chemical binding]; other site 1031709002319 SulA interaction site; other site 1031709002320 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 1031709002321 Protein of unknown function (DUF552); Region: DUF552; pfam04472 1031709002322 DivIVA protein; Region: DivIVA; pfam05103 1031709002323 DivIVA domain; Region: DivI1A_domain; TIGR03544 1031709002324 V-type ATP synthase subunit E; Provisional; Region: PRK02292 1031709002325 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 1031709002326 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 1031709002327 lipoprotein signal peptidase; Provisional; Region: PRK14787 1031709002328 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 1031709002329 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1031709002330 RNA binding surface [nucleotide binding]; other site 1031709002331 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1031709002332 active site 1031709002333 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1031709002334 pyruvate kinase; Provisional; Region: PRK06247 1031709002335 active site 1031709002336 domain interfaces; other site 1031709002337 CrcB-like protein; Region: CRCB; pfam02537 1031709002338 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 1031709002339 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 1031709002340 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1031709002341 active site 1031709002342 phosphorylation site [posttranslational modification] 1031709002343 intermolecular recognition site; other site 1031709002344 dimerization interface [polypeptide binding]; other site 1031709002345 ANTAR domain; Region: ANTAR; pfam03861 1031709002346 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1031709002347 CoenzymeA binding site [chemical binding]; other site 1031709002348 subunit interaction site [polypeptide binding]; other site 1031709002349 PHB binding site; other site 1031709002350 DNA polymerase I; Provisional; Region: PRK05755 1031709002351 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1031709002352 active site 1031709002353 metal binding site 1 [ion binding]; metal-binding site 1031709002354 putative 5' ssDNA interaction site; other site 1031709002355 metal binding site 3; metal-binding site 1031709002356 metal binding site 2 [ion binding]; metal-binding site 1031709002357 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1031709002358 putative DNA binding site [nucleotide binding]; other site 1031709002359 putative metal binding site [ion binding]; other site 1031709002360 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1031709002361 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1031709002362 active site 1031709002363 DNA binding site [nucleotide binding] 1031709002364 catalytic site [active] 1031709002365 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 1031709002366 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1031709002367 Hint domain; Region: Hint_2; pfam13403 1031709002368 FAD binding domain; Region: FAD_binding_4; pfam01565 1031709002369 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 1031709002370 active site 1031709002371 putative catalytic site [active] 1031709002372 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 1031709002373 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1031709002374 RNA binding site [nucleotide binding]; other site 1031709002375 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1031709002376 RNA binding site [nucleotide binding]; other site 1031709002377 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1031709002378 RNA binding site [nucleotide binding]; other site 1031709002379 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1031709002380 RNA binding site [nucleotide binding]; other site 1031709002381 domain interface; other site 1031709002382 Htaa; Region: HtaA; pfam04213 1031709002383 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 1031709002384 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1031709002385 intersubunit interface [polypeptide binding]; other site 1031709002386 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1031709002387 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1031709002388 ABC-ATPase subunit interface; other site 1031709002389 dimer interface [polypeptide binding]; other site 1031709002390 putative PBP binding regions; other site 1031709002391 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 1031709002392 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1031709002393 Walker A/P-loop; other site 1031709002394 ATP binding site [chemical binding]; other site 1031709002395 Q-loop/lid; other site 1031709002396 ABC transporter signature motif; other site 1031709002397 Walker B; other site 1031709002398 D-loop; other site 1031709002399 H-loop/switch region; other site 1031709002400 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1031709002401 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1031709002402 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1031709002403 Walker A/P-loop; other site 1031709002404 ATP binding site [chemical binding]; other site 1031709002405 Q-loop/lid; other site 1031709002406 ABC transporter signature motif; other site 1031709002407 Walker B; other site 1031709002408 D-loop; other site 1031709002409 H-loop/switch region; other site 1031709002410 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1031709002411 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1031709002412 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1031709002413 Walker A/P-loop; other site 1031709002414 ATP binding site [chemical binding]; other site 1031709002415 Q-loop/lid; other site 1031709002416 ABC transporter signature motif; other site 1031709002417 Walker B; other site 1031709002418 D-loop; other site 1031709002419 H-loop/switch region; other site 1031709002420 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1031709002421 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1031709002422 CoA-binding site [chemical binding]; other site 1031709002423 ATP-binding [chemical binding]; other site 1031709002424 Htaa; Region: HtaA; pfam04213 1031709002425 Htaa; Region: HtaA; pfam04213 1031709002426 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1031709002427 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 1031709002428 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1031709002429 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 1031709002430 metal ion-dependent adhesion site (MIDAS); other site 1031709002431 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1031709002432 Domain of unknown function (DUF3479); Region: DUF3479; pfam11965 1031709002433 CobN/Magnesium Chelatase; Region: CobN-Mg_chel; pfam02514 1031709002434 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1031709002435 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1031709002436 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1031709002437 Walker A/P-loop; other site 1031709002438 ATP binding site [chemical binding]; other site 1031709002439 Q-loop/lid; other site 1031709002440 ABC transporter signature motif; other site 1031709002441 Walker B; other site 1031709002442 D-loop; other site 1031709002443 H-loop/switch region; other site 1031709002444 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1031709002445 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1031709002446 ABC-ATPase subunit interface; other site 1031709002447 dimer interface [polypeptide binding]; other site 1031709002448 putative PBP binding regions; other site 1031709002449 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1031709002450 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1031709002451 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1031709002452 ABC transporter signature motif; other site 1031709002453 Walker B; other site 1031709002454 D-loop; other site 1031709002455 H-loop/switch region; other site 1031709002456 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1031709002457 Walker A/P-loop; other site 1031709002458 ATP binding site [chemical binding]; other site 1031709002459 Q-loop/lid; other site 1031709002460 Bacteriocin (Lactococcin_972); Region: Lactococcin_972; cl09891 1031709002461 excinuclease ABC subunit B; Provisional; Region: PRK05298 1031709002462 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1031709002463 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1031709002464 nucleotide binding region [chemical binding]; other site 1031709002465 ATP-binding site [chemical binding]; other site 1031709002466 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1031709002467 UvrB/uvrC motif; Region: UVR; pfam02151 1031709002468 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 1031709002469 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1031709002470 mycothiol-dependent maleylpyruvate isomerase; Reviewed; Region: PRK09583 1031709002471 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1031709002472 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1031709002473 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1031709002474 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1031709002475 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1031709002476 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1031709002477 iron-sulfur cluster [ion binding]; other site 1031709002478 [2Fe-2S] cluster binding site [ion binding]; other site 1031709002479 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1031709002480 catalytic core [active] 1031709002481 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1031709002482 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1031709002483 GIY-YIG motif/motif A; other site 1031709002484 active site 1031709002485 catalytic site [active] 1031709002486 putative DNA binding site [nucleotide binding]; other site 1031709002487 metal binding site [ion binding]; metal-binding site 1031709002488 UvrB/uvrC motif; Region: UVR; pfam02151 1031709002489 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1031709002490 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1031709002491 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1031709002492 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1031709002493 phosphate binding site [ion binding]; other site 1031709002494 putative substrate binding pocket [chemical binding]; other site 1031709002495 dimer interface [polypeptide binding]; other site 1031709002496 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1031709002497 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1031709002498 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1031709002499 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1031709002500 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1031709002501 Phosphoglycerate kinase; Region: PGK; pfam00162 1031709002502 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1031709002503 substrate binding site [chemical binding]; other site 1031709002504 hinge regions; other site 1031709002505 ADP binding site [chemical binding]; other site 1031709002506 catalytic site [active] 1031709002507 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1031709002508 triosephosphate isomerase; Provisional; Region: PRK14567 1031709002509 substrate binding site [chemical binding]; other site 1031709002510 dimer interface [polypeptide binding]; other site 1031709002511 catalytic triad [active] 1031709002512 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 1031709002513 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1031709002514 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 1031709002515 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1031709002516 active site 1031709002517 multimer interface [polypeptide binding]; other site 1031709002518 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 1031709002519 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1031709002520 B12 binding site [chemical binding]; other site 1031709002521 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1031709002522 FeS/SAM binding site; other site 1031709002523 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 1031709002524 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105 1031709002525 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 1031709002526 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1031709002527 homodimer interface [polypeptide binding]; other site 1031709002528 oligonucleotide binding site [chemical binding]; other site 1031709002529 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1031709002530 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1031709002531 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1031709002532 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1031709002533 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1031709002534 putative substrate translocation pore; other site 1031709002535 GTPase CgtA; Reviewed; Region: obgE; PRK12296 1031709002536 GTP1/OBG; Region: GTP1_OBG; pfam01018 1031709002537 Obg GTPase; Region: Obg; cd01898 1031709002538 G1 box; other site 1031709002539 GTP/Mg2+ binding site [chemical binding]; other site 1031709002540 Switch I region; other site 1031709002541 G2 box; other site 1031709002542 G3 box; other site 1031709002543 Switch II region; other site 1031709002544 G4 box; other site 1031709002545 G5 box; other site 1031709002546 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1031709002547 gamma-glutamyl kinase; Provisional; Region: PRK05429 1031709002548 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1031709002549 nucleotide binding site [chemical binding]; other site 1031709002550 homotetrameric interface [polypeptide binding]; other site 1031709002551 putative phosphate binding site [ion binding]; other site 1031709002552 putative allosteric binding site; other site 1031709002553 PUA domain; Region: PUA; pfam01472 1031709002554 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1031709002555 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1031709002556 putative catalytic cysteine [active] 1031709002557 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1031709002558 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1031709002559 active site 1031709002560 (T/H)XGH motif; other site 1031709002561 Oligomerisation domain; Region: Oligomerisation; pfam02410 1031709002562 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1031709002563 catalytic core [active] 1031709002564 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1031709002565 substrate binding site [chemical binding]; other site 1031709002566 AAA domain; Region: AAA_30; pfam13604 1031709002567 DNA protecting protein DprA; Region: dprA; TIGR00732 1031709002568 AAA domain; Region: AAA_21; pfam13304 1031709002569 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 1031709002570 putative active site [active] 1031709002571 putative metal-binding site [ion binding]; other site 1031709002572 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1031709002573 Part of AAA domain; Region: AAA_19; pfam13245 1031709002574 YodA lipocalin-like domain; Region: YodA; cl01365 1031709002575 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1031709002576 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 1031709002577 SpaB C-terminal domain; Region: SpaB_C; pfam14028 1031709002578 YcaO-like family; Region: YcaO; pfam02624 1031709002579 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 1031709002580 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 1031709002581 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1031709002582 FMN binding site [chemical binding]; other site 1031709002583 dimer interface [polypeptide binding]; other site 1031709002584 YodA lipocalin-like domain; Region: YodA; cl01365 1031709002585 potential frameshift: common BLAST hit: gi|221635485|ref|YP_002523361.1| domain protein 1031709002586 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 1031709002587 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1031709002588 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1031709002589 homodimer interface [polypeptide binding]; other site 1031709002590 catalytic residue [active] 1031709002591 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1031709002592 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1031709002593 Walker A/P-loop; other site 1031709002594 ATP binding site [chemical binding]; other site 1031709002595 Q-loop/lid; other site 1031709002596 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1031709002597 ABC transporter signature motif; other site 1031709002598 Walker B; other site 1031709002599 D-loop; other site 1031709002600 H-loop/switch region; other site 1031709002601 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1031709002602 Walker A/P-loop; other site 1031709002603 ATP binding site [chemical binding]; other site 1031709002604 Q-loop/lid; other site 1031709002605 ABC transporter signature motif; other site 1031709002606 Walker B; other site 1031709002607 D-loop; other site 1031709002608 H-loop/switch region; other site 1031709002609 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1031709002610 MarR family; Region: MarR_2; pfam12802 1031709002611 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1031709002612 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1031709002613 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 1031709002614 active site 1031709002615 substrate binding pocket [chemical binding]; other site 1031709002616 homodimer interaction site [polypeptide binding]; other site 1031709002617 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 1031709002618 active site 1031709002619 dimer interface [polypeptide binding]; other site 1031709002620 magnesium binding site [ion binding]; other site 1031709002621 L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209 1031709002622 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1031709002623 AP (apurinic/apyrimidinic) site pocket; other site 1031709002624 DNA interaction; other site 1031709002625 Metal-binding active site; metal-binding site 1031709002626 L-ribulose-5-phosphate 4-epimerase; Validated; Region: PRK06557 1031709002627 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1031709002628 intersubunit interface [polypeptide binding]; other site 1031709002629 active site 1031709002630 Zn2+ binding site [ion binding]; other site 1031709002631 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1031709002632 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1031709002633 substrate binding site [chemical binding]; other site 1031709002634 ATP binding site [chemical binding]; other site 1031709002635 benzoate transport; Region: 2A0115; TIGR00895 1031709002636 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1031709002637 putative substrate translocation pore; other site 1031709002638 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1031709002639 substrate binding site [chemical binding]; other site 1031709002640 multimerization interface [polypeptide binding]; other site 1031709002641 ATP binding site [chemical binding]; other site 1031709002642 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1031709002643 thiamine phosphate binding site [chemical binding]; other site 1031709002644 active site 1031709002645 pyrophosphate binding site [ion binding]; other site 1031709002646 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 1031709002647 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 1031709002648 dimer interface [polypeptide binding]; other site 1031709002649 NAD binding site [chemical binding]; other site 1031709002650 substrate binding site [chemical binding]; other site 1031709002651 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1031709002652 malate dehydrogenase; Provisional; Region: PRK13529 1031709002653 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1031709002654 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1031709002655 NAD(P) binding site [chemical binding]; other site 1031709002656 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 1031709002657 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 1031709002658 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1031709002659 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1031709002660 HIGH motif; other site 1031709002661 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1031709002662 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1031709002663 active site 1031709002664 KMSKS motif; other site 1031709002665 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1031709002666 tRNA binding surface [nucleotide binding]; other site 1031709002667 SLBB domain; Region: SLBB; pfam10531 1031709002668 comEA protein; Region: comE; TIGR01259 1031709002669 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1031709002670 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1031709002671 Competence protein; Region: Competence; pfam03772 1031709002672 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 1031709002673 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1031709002674 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1031709002675 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1031709002676 ATP binding site [chemical binding]; other site 1031709002677 putative Mg++ binding site [ion binding]; other site 1031709002678 hypothetical protein; Reviewed; Region: PRK07914 1031709002679 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1031709002680 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1031709002681 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1031709002682 active site 1031709002683 catalytic site [active] 1031709002684 GTP-binding protein LepA; Provisional; Region: PRK05433 1031709002685 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1031709002686 G1 box; other site 1031709002687 putative GEF interaction site [polypeptide binding]; other site 1031709002688 GTP/Mg2+ binding site [chemical binding]; other site 1031709002689 Switch I region; other site 1031709002690 G2 box; other site 1031709002691 G3 box; other site 1031709002692 Switch II region; other site 1031709002693 G4 box; other site 1031709002694 G5 box; other site 1031709002695 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 1031709002696 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1031709002697 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1031709002698 O-succinylbenzoate synthase; Provisional; Region: PRK02901 1031709002699 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 1031709002700 active site 1031709002701 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase; Region: menD; TIGR00173 1031709002702 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1031709002703 dimer interface [polypeptide binding]; other site 1031709002704 tetramer interface [polypeptide binding]; other site 1031709002705 PYR/PP interface [polypeptide binding]; other site 1031709002706 TPP binding site [chemical binding]; other site 1031709002707 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1031709002708 TPP-binding site [chemical binding]; other site 1031709002709 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 1031709002710 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1031709002711 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1031709002712 acyl-activating enzyme (AAE) consensus motif; other site 1031709002713 AMP binding site [chemical binding]; other site 1031709002714 active site 1031709002715 CoA binding site [chemical binding]; other site 1031709002716 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1031709002717 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1031709002718 substrate binding site [chemical binding]; other site 1031709002719 oxyanion hole (OAH) forming residues; other site 1031709002720 trimer interface [polypeptide binding]; other site 1031709002721 Rhomboid family; Region: Rhomboid; pfam01694 1031709002722 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1031709002723 acyl-activating enzyme (AAE) consensus motif; other site 1031709002724 CoA binding site [chemical binding]; other site 1031709002725 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1031709002726 coproporphyrinogen III oxidase; Validated; Region: PRK05628 1031709002727 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1031709002728 FeS/SAM binding site; other site 1031709002729 HemN C-terminal domain; Region: HemN_C; pfam06969 1031709002730 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 1031709002731 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1031709002732 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1031709002733 active site 1031709002734 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1031709002735 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1031709002736 chaperone protein DnaJ; Provisional; Region: PRK14278 1031709002737 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1031709002738 HSP70 interaction site [polypeptide binding]; other site 1031709002739 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1031709002740 Zn binding sites [ion binding]; other site 1031709002741 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1031709002742 dimer interface [polypeptide binding]; other site 1031709002743 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 1031709002744 RNA methyltransferase, RsmE family; Region: TIGR00046 1031709002745 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1031709002746 L-iditol 2-dehydrogenase; Region: iditol_2_DH_like; cd08235 1031709002747 putative NAD(P) binding site [chemical binding]; other site 1031709002748 catalytic Zn binding site [ion binding]; other site 1031709002749 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 1031709002750 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 1031709002751 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 1031709002752 active site 1031709002753 P-loop; other site 1031709002754 phosphorylation site [posttranslational modification] 1031709002755 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1031709002756 active site 1031709002757 phosphorylation site [posttranslational modification] 1031709002758 Predicted membrane protein [Function unknown]; Region: COG2259 1031709002759 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1031709002760 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1031709002761 ATP binding site [chemical binding]; other site 1031709002762 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1031709002763 putative Mg++ binding site [ion binding]; other site 1031709002764 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1031709002765 nucleotide binding region [chemical binding]; other site 1031709002766 ATP-binding site [chemical binding]; other site 1031709002767 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1031709002768 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1031709002769 EamA-like transporter family; Region: EamA; pfam00892 1031709002770 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 1031709002771 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1031709002772 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1031709002773 Histidine kinase; Region: HisKA_3; pfam07730 1031709002774 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1031709002775 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1031709002776 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1031709002777 active site 1031709002778 phosphorylation site [posttranslational modification] 1031709002779 intermolecular recognition site; other site 1031709002780 dimerization interface [polypeptide binding]; other site 1031709002781 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1031709002782 DNA binding residues [nucleotide binding] 1031709002783 dimerization interface [polypeptide binding]; other site 1031709002784 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 1031709002785 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1031709002786 Walker A/P-loop; other site 1031709002787 ATP binding site [chemical binding]; other site 1031709002788 Q-loop/lid; other site 1031709002789 ABC transporter signature motif; other site 1031709002790 Walker B; other site 1031709002791 D-loop; other site 1031709002792 H-loop/switch region; other site 1031709002793 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1031709002794 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1031709002795 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1031709002796 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1031709002797 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 1031709002798 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 1031709002799 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1031709002800 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1031709002801 PhoH-like protein; Region: PhoH; pfam02562 1031709002802 metal-binding heat shock protein; Provisional; Region: PRK00016 1031709002803 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1031709002804 Domain of unknown function DUF21; Region: DUF21; pfam01595 1031709002805 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1031709002806 Transporter associated domain; Region: CorC_HlyC; smart01091 1031709002807 GTPase Era; Reviewed; Region: era; PRK00089 1031709002808 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1031709002809 G1 box; other site 1031709002810 GTP/Mg2+ binding site [chemical binding]; other site 1031709002811 Switch I region; other site 1031709002812 G2 box; other site 1031709002813 Switch II region; other site 1031709002814 G3 box; other site 1031709002815 G4 box; other site 1031709002816 G5 box; other site 1031709002817 KH domain; Region: KH_2; pfam07650 1031709002818 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1031709002819 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1031709002820 active site 1031709002821 2-isopropylmalate synthase; Validated; Region: PRK03739 1031709002822 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 1031709002823 active site 1031709002824 catalytic residues [active] 1031709002825 metal binding site [ion binding]; metal-binding site 1031709002826 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1031709002827 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1031709002828 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1031709002829 catalytic residue [active] 1031709002830 putative FPP diphosphate binding site; other site 1031709002831 putative FPP binding hydrophobic cleft; other site 1031709002832 dimer interface [polypeptide binding]; other site 1031709002833 putative IPP diphosphate binding site; other site 1031709002834 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 1031709002835 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1031709002836 Recombination protein O N terminal; Region: RecO_N; pfam11967 1031709002837 Recombination protein O C terminal; Region: RecO_C; pfam02565 1031709002838 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1031709002839 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1031709002840 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1031709002841 active site 1031709002842 phosphorylation site [posttranslational modification] 1031709002843 intermolecular recognition site; other site 1031709002844 dimerization interface [polypeptide binding]; other site 1031709002845 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1031709002846 DNA binding residues [nucleotide binding] 1031709002847 dimerization interface [polypeptide binding]; other site 1031709002848 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1031709002849 metal binding site 2 [ion binding]; metal-binding site 1031709002850 putative DNA binding helix; other site 1031709002851 metal binding site 1 [ion binding]; metal-binding site 1031709002852 dimer interface [polypeptide binding]; other site 1031709002853 structural Zn2+ binding site [ion binding]; other site 1031709002854 glycyl-tRNA synthetase; Provisional; Region: PRK04173 1031709002855 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1031709002856 motif 1; other site 1031709002857 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 1031709002858 active site 1031709002859 motif 2; other site 1031709002860 motif 3; other site 1031709002861 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 1031709002862 anticodon binding site; other site 1031709002863 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 1031709002864 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 1031709002865 proximal heme binding site [chemical binding]; other site 1031709002866 distal heme binding site [chemical binding]; other site 1031709002867 putative dimer interface [polypeptide binding]; other site 1031709002868 putative Iron-sulfur protein interface [polypeptide binding]; other site 1031709002869 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 1031709002870 L-aspartate oxidase; Provisional; Region: PRK06175 1031709002871 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1031709002872 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 1031709002873 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1031709002874 4Fe-4S binding domain; Region: Fer4; pfam00037 1031709002875 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 1031709002876 putative FMN binding site [chemical binding]; other site 1031709002877 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 1031709002878 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1031709002879 putative dimer interface [polypeptide binding]; other site 1031709002880 active site pocket [active] 1031709002881 putative cataytic base [active] 1031709002882 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1031709002883 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1031709002884 FMN binding site [chemical binding]; other site 1031709002885 active site 1031709002886 catalytic residues [active] 1031709002887 substrate binding site [chemical binding]; other site 1031709002888 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1031709002889 Zn2+ binding site [ion binding]; other site 1031709002890 Mg2+ binding site [ion binding]; other site 1031709002891 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1031709002892 Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424 1031709002893 DNA primase; Validated; Region: dnaG; PRK05667 1031709002894 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1031709002895 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1031709002896 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1031709002897 active site 1031709002898 metal binding site [ion binding]; metal-binding site 1031709002899 interdomain interaction site; other site 1031709002900 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1031709002901 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 1031709002902 DNA-directed RNA polymerase specialized sigma subunit [Transcription]; Region: FliA; COG1191 1031709002903 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1031709002904 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1031709002905 DNA binding residues [nucleotide binding] 1031709002906 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1031709002907 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 1031709002908 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1031709002909 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1031709002910 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 1031709002911 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 1031709002912 active site 1031709002913 homotetramer interface [polypeptide binding]; other site 1031709002914 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 1031709002915 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 1031709002916 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1031709002917 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1031709002918 dimer interface [polypeptide binding]; other site 1031709002919 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1031709002920 catalytic residue [active] 1031709002921 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1031709002922 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1031709002923 DNA-binding site [nucleotide binding]; DNA binding site 1031709002924 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1031709002925 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1031709002926 homodimer interface [polypeptide binding]; other site 1031709002927 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1031709002928 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1031709002929 active site 1031709002930 multimer interface [polypeptide binding]; other site 1031709002931 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1031709002932 predicted active site [active] 1031709002933 catalytic triad [active] 1031709002934 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 1031709002935 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1031709002936 inhibitor-cofactor binding pocket; inhibition site 1031709002937 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1031709002938 catalytic residue [active] 1031709002939 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1031709002940 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1031709002941 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1031709002942 potential protein location (hypothetical protein TIB1ST10_05000 [Propionibacterium acnes 6609]) that overlaps RNA (tRNA-M) 1031709002943 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1031709002944 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1031709002945 active site 1031709002946 motif I; other site 1031709002947 motif II; other site 1031709002948 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1031709002949 MoxR-like ATPases [General function prediction only]; Region: COG0714 1031709002950 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1031709002951 Walker A motif; other site 1031709002952 ATP binding site [chemical binding]; other site 1031709002953 Walker B motif; other site 1031709002954 arginine finger; other site 1031709002955 Protein of unknown function DUF58; Region: DUF58; pfam01882 1031709002956 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1031709002957 hypothetical protein; Provisional; Region: PRK13685 1031709002958 von Willebrand factor type A domain; Region: VWA_2; pfam13519 1031709002959 metal ion-dependent adhesion site (MIDAS); other site 1031709002960 Protein-interacting Bro1-like domain of mammalian Alix and related domains; Region: BRO1_Alix_like; cl14649 1031709002961 von Willebrand factor type A domain; Region: VWA_2; pfam13519 1031709002962 metal ion-dependent adhesion site (MIDAS); other site 1031709002963 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1031709002964 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1031709002965 catalytic residue [active] 1031709002966 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 1031709002967 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1031709002968 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1031709002969 dimer interface [polypeptide binding]; other site 1031709002970 active site 1031709002971 acyl carrier protein; Provisional; Region: acpP; PRK00982 1031709002972 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1031709002973 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1031709002974 dimer interface [polypeptide binding]; other site 1031709002975 active site 1031709002976 CoA binding pocket [chemical binding]; other site 1031709002977 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1031709002978 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1031709002979 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1031709002980 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1031709002981 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cl00252 1031709002982 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1031709002983 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1031709002984 putative substrate translocation pore; other site 1031709002985 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1031709002986 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1031709002987 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1031709002988 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1031709002989 dimer interface [polypeptide binding]; other site 1031709002990 TPP-binding site [chemical binding]; other site 1031709002991 Endo-beta-N-acetylglucosaminidases are bacterial chitinases that hydrolyze the chitin core of various asparagine (N)-linked glycans and glycoproteins. The endo-beta-N-acetylglucosaminidases have a glycosyl hydrolase family 18 (GH18) catalytic domain; Region: GH18_EndoS-like; cd06542 1031709002992 active site 1031709002993 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 1031709002994 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 1031709002995 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 1031709002996 Isochorismatase family; Region: Isochorismatase; pfam00857 1031709002997 catalytic triad [active] 1031709002998 metal binding site [ion binding]; metal-binding site 1031709002999 conserved cis-peptide bond; other site 1031709003000 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1031709003001 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1031709003002 active site 1031709003003 catalytic tetrad [active] 1031709003004 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1031709003005 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1031709003006 active site 1031709003007 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1031709003008 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1031709003009 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1031709003010 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1031709003011 dihydroorotase; Validated; Region: pyrC; PRK09357 1031709003012 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1031709003013 active site 1031709003014 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1031709003015 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 1031709003016 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1031709003017 catalytic site [active] 1031709003018 subunit interface [polypeptide binding]; other site 1031709003019 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1031709003020 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1031709003021 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1031709003022 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1031709003023 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1031709003024 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1031709003025 MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245 1031709003026 substrate binding site [chemical binding]; other site 1031709003027 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 1031709003028 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 1031709003029 FAD binding pocket [chemical binding]; other site 1031709003030 FAD binding motif [chemical binding]; other site 1031709003031 phosphate binding motif [ion binding]; other site 1031709003032 beta-alpha-beta structure motif; other site 1031709003033 NAD binding pocket [chemical binding]; other site 1031709003034 Iron coordination center [ion binding]; other site 1031709003035 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 1031709003036 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 1031709003037 heterodimer interface [polypeptide binding]; other site 1031709003038 active site 1031709003039 FMN binding site [chemical binding]; other site 1031709003040 homodimer interface [polypeptide binding]; other site 1031709003041 substrate binding site [chemical binding]; other site 1031709003042 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1031709003043 active site 1031709003044 dimer interface [polypeptide binding]; other site 1031709003045 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1031709003046 active site 1031709003047 Fructosamine kinase; Region: Fructosamin_kin; cl17579 1031709003048 Phosphotransferase enzyme family; Region: APH; pfam01636 1031709003049 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 1031709003050 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1031709003051 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1031709003052 Competence-damaged protein; Region: CinA; pfam02464 1031709003053 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1031709003054 non-specific DNA binding site [nucleotide binding]; other site 1031709003055 salt bridge; other site 1031709003056 sequence-specific DNA binding site [nucleotide binding]; other site 1031709003057 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1031709003058 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1031709003059 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1031709003060 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 1031709003061 recombinase A; Provisional; Region: recA; PRK09354 1031709003062 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1031709003063 hexamer interface [polypeptide binding]; other site 1031709003064 Walker A motif; other site 1031709003065 ATP binding site [chemical binding]; other site 1031709003066 Walker B motif; other site 1031709003067 recombination regulator RecX; Reviewed; Region: recX; PRK00117 1031709003068 hypothetical protein; Provisional; Region: PRK12705 1031709003069 KH domain; Region: KH_1; pfam00013 1031709003070 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1031709003071 Zn2+ binding site [ion binding]; other site 1031709003072 Mg2+ binding site [ion binding]; other site 1031709003073 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 1031709003074 active site 1031709003075 catalytic residues [active] 1031709003076 Predicted membrane protein [Function unknown]; Region: COG1288 1031709003077 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1031709003078 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 1031709003079 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1031709003080 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1031709003081 FeS/SAM binding site; other site 1031709003082 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 1031709003083 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1031709003084 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1031709003085 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1031709003086 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1031709003087 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1031709003088 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1031709003089 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1031709003090 HflX GTPase family; Region: HflX; cd01878 1031709003091 G1 box; other site 1031709003092 GTP/Mg2+ binding site [chemical binding]; other site 1031709003093 Switch I region; other site 1031709003094 G2 box; other site 1031709003095 G3 box; other site 1031709003096 Switch II region; other site 1031709003097 G4 box; other site 1031709003098 G5 box; other site 1031709003099 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1031709003100 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1031709003101 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1031709003102 putative Mg++ binding site [ion binding]; other site 1031709003103 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1031709003104 LexA repressor; Validated; Region: PRK00215 1031709003105 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1031709003106 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1031709003107 Catalytic site [active] 1031709003108 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1031709003109 ATP cone domain; Region: ATP-cone; pfam03477 1031709003110 vitamin B12-dependent ribonucleotide reductase; Validated; Region: PRK06556 1031709003111 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 1031709003112 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 1031709003113 active site 1031709003114 dimer interface [polypeptide binding]; other site 1031709003115 effector binding site; other site 1031709003116 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1031709003117 TSCPD domain; Region: TSCPD; pfam12637 1031709003118 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1031709003119 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1031709003120 Ligand Binding Site [chemical binding]; other site 1031709003121 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1031709003122 Ligand Binding Site [chemical binding]; other site 1031709003123 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 1031709003124 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1031709003125 ATP binding site [chemical binding]; other site 1031709003126 putative Mg++ binding site [ion binding]; other site 1031709003127 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1031709003128 nucleotide binding region [chemical binding]; other site 1031709003129 ATP-binding site [chemical binding]; other site 1031709003130 Helicase associated domain (HA2); Region: HA2; pfam04408 1031709003131 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 1031709003132 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 1031709003133 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 1031709003134 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1031709003135 active site 1031709003136 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1031709003137 catalytic triad [active] 1031709003138 dimer interface [polypeptide binding]; other site 1031709003139 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 1031709003140 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1031709003141 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1031709003142 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1031709003143 Sigma-70, region 4; Region: Sigma70_r4; pfam04545 1031709003144 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 1031709003145 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1031709003146 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1031709003147 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1031709003148 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1031709003149 DNA binding residues [nucleotide binding] 1031709003150 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 1031709003151 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1031709003152 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1031709003153 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1031709003154 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1031709003155 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1031709003156 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1031709003157 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1031709003158 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1031709003159 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1031709003160 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 1031709003161 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1031709003162 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1031709003163 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1031709003164 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 1031709003165 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1031709003166 Mg2+ binding site [ion binding]; other site 1031709003167 G-X-G motif; other site 1031709003168 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1031709003169 anchoring element; other site 1031709003170 dimer interface [polypeptide binding]; other site 1031709003171 ATP binding site [chemical binding]; other site 1031709003172 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1031709003173 active site 1031709003174 metal binding site [ion binding]; metal-binding site 1031709003175 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1031709003176 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 1031709003177 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 1031709003178 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 1031709003179 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1031709003180 putative substrate translocation pore; other site 1031709003181 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 1031709003182 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1031709003183 CAP-like domain; other site 1031709003184 active site 1031709003185 primary dimer interface [polypeptide binding]; other site 1031709003186 Uncharacterized conserved protein [Function unknown]; Region: COG4850 1031709003187 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 1031709003188 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 1031709003189 Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; cl17415 1031709003190 thymidine kinase; Provisional; Region: PRK04296 1031709003191 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 1031709003192 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 1031709003193 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 1031709003194 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 1031709003195 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1031709003196 trimer interface [polypeptide binding]; other site 1031709003197 active site 1031709003198 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 1031709003199 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1031709003200 ssDNA binding site; other site 1031709003201 generic binding surface II; other site 1031709003202 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1031709003203 TrkA-N domain; Region: TrkA_N; pfam02254 1031709003204 TrkA-C domain; Region: TrkA_C; pfam02080 1031709003205 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1031709003206 TrkA-N domain; Region: TrkA_N; pfam02254 1031709003207 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1031709003208 TRAM domain; Region: TRAM; cl01282 1031709003209 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1031709003210 aconitate hydratase; Validated; Region: PRK09277 1031709003211 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1031709003212 substrate binding site [chemical binding]; other site 1031709003213 ligand binding site [chemical binding]; other site 1031709003214 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1031709003215 substrate binding site [chemical binding]; other site 1031709003216 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1031709003217 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1031709003218 TPP-binding site; other site 1031709003219 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1031709003220 PYR/PP interface [polypeptide binding]; other site 1031709003221 dimer interface [polypeptide binding]; other site 1031709003222 TPP binding site [chemical binding]; other site 1031709003223 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1031709003224 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 1031709003225 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1031709003226 catalytic site [active] 1031709003227 putative active site [active] 1031709003228 putative substrate binding site [chemical binding]; other site 1031709003229 HRDC domain; Region: HRDC; pfam00570 1031709003230 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 1031709003231 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 1031709003232 SelR domain; Region: SelR; pfam01641 1031709003233 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 1031709003234 active site 1031709003235 YheO-like PAS domain; Region: PAS_6; pfam08348 1031709003236 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 1031709003237 HTH domain; Region: HTH_22; pfam13309 1031709003238 tryptophanase/L-cysteine desulfhydrase, PLP-dependent; Provisional; Region: tnaA; PRK13238 1031709003239 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1031709003240 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1031709003241 catalytic residue [active] 1031709003242 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1031709003243 potential frameshift: common BLAST hit: gi|295130631|ref|YP_003581294.1| polyphosphate:nucleotide phosphotransferase, PPK2 family 1031709003244 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1031709003245 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1031709003246 putative NAD(P) binding site [chemical binding]; other site 1031709003247 putative substrate binding site [chemical binding]; other site 1031709003248 catalytic Zn binding site [ion binding]; other site 1031709003249 structural Zn binding site [ion binding]; other site 1031709003250 dimer interface [polypeptide binding]; other site 1031709003251 LrgB-like family; Region: LrgB; cl00596 1031709003252 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1031709003253 Histidine kinase; Region: HisKA_3; pfam07730 1031709003254 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1031709003255 ATP binding site [chemical binding]; other site 1031709003256 Mg2+ binding site [ion binding]; other site 1031709003257 G-X-G motif; other site 1031709003258 potential frameshift: common BLAST hit: gi|365973943|ref|YP_004955502.1| putative Hemoglobin-dependent two component system response 1031709003259 Response regulator receiver domain; Region: Response_reg; pfam00072 1031709003260 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1031709003261 active site 1031709003262 phosphorylation site [posttranslational modification] 1031709003263 intermolecular recognition site; other site 1031709003264 dimerization interface [polypeptide binding]; other site 1031709003265 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 1031709003266 DNA binding residues [nucleotide binding] 1031709003267 dimerization interface [polypeptide binding]; other site 1031709003268 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 1031709003269 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 1031709003270 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1031709003271 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1031709003272 active site 1031709003273 dimer interface [polypeptide binding]; other site 1031709003274 motif 1; other site 1031709003275 motif 2; other site 1031709003276 motif 3; other site 1031709003277 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1031709003278 anticodon binding site; other site 1031709003279 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 1031709003280 nucleotide binding site/active site [active] 1031709003281 HIT family signature motif; other site 1031709003282 catalytic residue [active] 1031709003283 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1031709003284 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1031709003285 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1031709003286 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 1031709003287 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 1031709003288 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1031709003289 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1031709003290 lipoyl attachment site [posttranslational modification]; other site 1031709003291 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1031709003292 Double zinc ribbon; Region: DZR; pfam12773 1031709003293 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1031709003294 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1031709003295 phosphopeptide binding site; other site 1031709003296 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1031709003297 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1031709003298 DNA binding residues [nucleotide binding] 1031709003299 Bifunctional nuclease; Region: DNase-RNase; pfam02577 1031709003300 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1031709003301 DNA binding residues [nucleotide binding] 1031709003302 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1031709003303 putative dimer interface [polypeptide binding]; other site 1031709003304 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 1031709003305 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1031709003306 pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated; Region: PRK06555 1031709003307 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 1031709003308 active site 1031709003309 ADP/pyrophosphate binding site [chemical binding]; other site 1031709003310 fructose-1,6-bisphosphate binding site; other site 1031709003311 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 1031709003312 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 1031709003313 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1031709003314 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1031709003315 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1031709003316 Uncharacterized conserved protein [Function unknown]; Region: COG1739 1031709003317 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1031709003318 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1031709003319 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1031709003320 PAC2 family; Region: PAC2; pfam09754 1031709003321 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 1031709003322 active site 1031709003323 acyl-CoA esterase; Provisional; Region: PRK10673 1031709003324 hypothetical protein; Provisional; Region: PRK03298 1031709003325 DivIVA protein; Region: DivIVA; pfam05103 1031709003326 V-type ATP synthase subunit E; Provisional; Region: PRK01558 1031709003327 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1031709003328 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 1031709003329 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1031709003330 dimer interface [polypeptide binding]; other site 1031709003331 substrate binding site [chemical binding]; other site 1031709003332 metal binding site [ion binding]; metal-binding site 1031709003333 phosphoglucomutase; Validated; Region: PRK07564 1031709003334 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 1031709003335 active site 1031709003336 substrate binding site [chemical binding]; other site 1031709003337 metal binding site [ion binding]; metal-binding site 1031709003338 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1031709003339 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 1031709003340 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1031709003341 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1031709003342 motif II; other site 1031709003343 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1031709003344 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 1031709003345 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1031709003346 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1031709003347 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1031709003348 active site turn [active] 1031709003349 phosphorylation site [posttranslational modification] 1031709003350 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1031709003351 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 1031709003352 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1031709003353 HPr interaction site; other site 1031709003354 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1031709003355 active site 1031709003356 phosphorylation site [posttranslational modification] 1031709003357 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1031709003358 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1031709003359 nudix motif; other site 1031709003360 glycogen branching enzyme; Provisional; Region: PRK12313 1031709003361 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1031709003362 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1031709003363 active site 1031709003364 catalytic site [active] 1031709003365 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1031709003366 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 1031709003367 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 1031709003368 trehalose synthase; Region: treS_nterm; TIGR02456 1031709003369 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 1031709003370 active site 1031709003371 catalytic site [active] 1031709003372 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 1031709003373 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 1031709003374 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1031709003375 active site 1031709003376 homodimer interface [polypeptide binding]; other site 1031709003377 catalytic site [active] 1031709003378 acceptor binding site [chemical binding]; other site 1031709003379 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1031709003380 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1031709003381 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1031709003382 active site 1031709003383 catalytic site [active] 1031709003384 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1031709003385 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1031709003386 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1031709003387 catalytic residue [active] 1031709003388 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 1031709003389 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1031709003390 Ligand Binding Site [chemical binding]; other site 1031709003391 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 1031709003392 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 1031709003393 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1031709003394 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1031709003395 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1031709003396 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1031709003397 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1031709003398 GatB domain; Region: GatB_Yqey; smart00845 1031709003399 TIGR03085 family protein; Region: TIGR03085 1031709003400 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1031709003401 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1031709003402 anthranilate synthase component I; Provisional; Region: PRK13571 1031709003403 anthranilate synthase component I; Provisional; Region: PRK13571 1031709003404 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; cl17850 1031709003405 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1031709003406 active site 1031709003407 ribulose/triose binding site [chemical binding]; other site 1031709003408 phosphate binding site [ion binding]; other site 1031709003409 substrate (anthranilate) binding pocket [chemical binding]; other site 1031709003410 product (indole) binding pocket [chemical binding]; other site 1031709003411 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1031709003412 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1031709003413 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1031709003414 catalytic residue [active] 1031709003415 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1031709003416 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1031709003417 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1031709003418 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1031709003419 active site 1031709003420 dimer interface [polypeptide binding]; other site 1031709003421 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1031709003422 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1031709003423 active site 1031709003424 FMN binding site [chemical binding]; other site 1031709003425 substrate binding site [chemical binding]; other site 1031709003426 3Fe-4S cluster binding site [ion binding]; other site 1031709003427 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1031709003428 domain interface; other site 1031709003429 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 1031709003430 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1031709003431 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1031709003432 Beta-lactamase; Region: Beta-lactamase; cl17358 1031709003433 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 1031709003434 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1031709003435 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1031709003436 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1031709003437 putative active site [active] 1031709003438 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 1031709003439 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1031709003440 putative active site [active] 1031709003441 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1031709003442 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 1031709003443 active site turn [active] 1031709003444 phosphorylation site [posttranslational modification] 1031709003445 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1031709003446 Uncharacterized conserved protein [Function unknown]; Region: COG3589 1031709003447 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1031709003448 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1031709003449 beta-galactosidase; Region: BGL; TIGR03356 1031709003450 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1031709003451 active site 1031709003452 P-loop; other site 1031709003453 phosphorylation site [posttranslational modification] 1031709003454 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1031709003455 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1031709003456 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1031709003457 methionine cluster; other site 1031709003458 active site 1031709003459 phosphorylation site [posttranslational modification] 1031709003460 metal binding site [ion binding]; metal-binding site 1031709003461 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1031709003462 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 1031709003463 active site 1031709003464 PHP Thumb interface [polypeptide binding]; other site 1031709003465 metal binding site [ion binding]; metal-binding site 1031709003466 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1031709003467 generic binding surface II; other site 1031709003468 generic binding surface I; other site 1031709003469 histidinol dehydrogenase; Region: hisD; TIGR00069 1031709003470 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1031709003471 NAD binding site [chemical binding]; other site 1031709003472 dimerization interface [polypeptide binding]; other site 1031709003473 product binding site; other site 1031709003474 substrate binding site [chemical binding]; other site 1031709003475 zinc binding site [ion binding]; other site 1031709003476 catalytic residues [active] 1031709003477 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 1031709003478 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1031709003479 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1031709003480 homodimer interface [polypeptide binding]; other site 1031709003481 catalytic residue [active] 1031709003482 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1031709003483 putative active site pocket [active] 1031709003484 4-fold oligomerization interface [polypeptide binding]; other site 1031709003485 metal binding residues [ion binding]; metal-binding site 1031709003486 3-fold/trimer interface [polypeptide binding]; other site 1031709003487 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 1031709003488 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1031709003489 putative active site [active] 1031709003490 oxyanion strand; other site 1031709003491 catalytic triad [active] 1031709003492 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1031709003493 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 1031709003494 catalytic residues [active] 1031709003495 hypothetical protein; Validated; Region: PRK00110 1031709003496 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 1031709003497 active site 1031709003498 putative DNA-binding cleft [nucleotide binding]; other site 1031709003499 dimer interface [polypeptide binding]; other site 1031709003500 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1031709003501 RuvA N terminal domain; Region: RuvA_N; pfam01330 1031709003502 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1031709003503 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1031709003504 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1031709003505 Walker A motif; other site 1031709003506 ATP binding site [chemical binding]; other site 1031709003507 Walker B motif; other site 1031709003508 arginine finger; other site 1031709003509 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1031709003510 Preprotein translocase subunit; Region: YajC; pfam02699 1031709003511 Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342 1031709003512 Protein export membrane protein; Region: SecD_SecF; cl14618 1031709003513 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1031709003514 Protein export membrane protein; Region: SecD_SecF; pfam02355 1031709003515 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1031709003516 active site 1031709003517 Ion channel; Region: Ion_trans_2; pfam07885 1031709003518 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1031709003519 TrkA-N domain; Region: TrkA_N; pfam02254 1031709003520 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1031709003521 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1031709003522 Zn2+ binding site [ion binding]; other site 1031709003523 Mg2+ binding site [ion binding]; other site 1031709003524 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1031709003525 synthetase active site [active] 1031709003526 NTP binding site [chemical binding]; other site 1031709003527 metal binding site [ion binding]; metal-binding site 1031709003528 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1031709003529 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1031709003530 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1031709003531 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1031709003532 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1031709003533 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1031709003534 histidyl-tRNA synthetase; Region: hisS; TIGR00442 1031709003535 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1031709003536 dimer interface [polypeptide binding]; other site 1031709003537 motif 1; other site 1031709003538 active site 1031709003539 motif 2; other site 1031709003540 motif 3; other site 1031709003541 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1031709003542 anticodon binding site; other site 1031709003543 Protein of unknown function (DUF998); Region: DUF998; pfam06197 1031709003544 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1031709003545 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1031709003546 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1031709003547 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 1031709003548 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1031709003549 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 1031709003550 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 1031709003551 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 1031709003552 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1031709003553 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1031709003554 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1031709003555 dimer interface [polypeptide binding]; other site 1031709003556 anticodon binding site; other site 1031709003557 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1031709003558 homodimer interface [polypeptide binding]; other site 1031709003559 motif 1; other site 1031709003560 active site 1031709003561 motif 2; other site 1031709003562 GAD domain; Region: GAD; pfam02938 1031709003563 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1031709003564 active site 1031709003565 motif 3; other site 1031709003566 recombination factor protein RarA; Reviewed; Region: PRK13342 1031709003567 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1031709003568 Walker A motif; other site 1031709003569 ATP binding site [chemical binding]; other site 1031709003570 Walker B motif; other site 1031709003571 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1031709003572 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1031709003573 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1031709003574 motif 1; other site 1031709003575 active site 1031709003576 motif 2; other site 1031709003577 motif 3; other site 1031709003578 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1031709003579 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 1031709003580 YceG-like family; Region: YceG; pfam02618 1031709003581 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1031709003582 dimerization interface [polypeptide binding]; other site 1031709003583 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1031709003584 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1031709003585 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1031709003586 shikimate binding site; other site 1031709003587 NAD(P) binding site [chemical binding]; other site 1031709003588 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1031709003589 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1031709003590 Tetramer interface [polypeptide binding]; other site 1031709003591 active site 1031709003592 FMN-binding site [chemical binding]; other site 1031709003593 shikimate kinase; Reviewed; Region: aroK; PRK00131 1031709003594 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1031709003595 ADP binding site [chemical binding]; other site 1031709003596 magnesium binding site [ion binding]; other site 1031709003597 putative shikimate binding site; other site 1031709003598 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1031709003599 dimer interface [polypeptide binding]; other site 1031709003600 active site 1031709003601 metal binding site [ion binding]; metal-binding site 1031709003602 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 1031709003603 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 1031709003604 putative active site [active] 1031709003605 putative metal binding site [ion binding]; other site 1031709003606 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 1031709003607 elongation factor P; Validated; Region: PRK00529 1031709003608 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1031709003609 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1031709003610 RNA binding site [nucleotide binding]; other site 1031709003611 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1031709003612 RNA binding site [nucleotide binding]; other site 1031709003613 transcription antitermination factor NusB; Region: nusB; TIGR01951 1031709003614 putative RNA binding site [nucleotide binding]; other site 1031709003615 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1031709003616 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1031709003617 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1031709003618 catalytic site [active] 1031709003619 G-X2-G-X-G-K; other site 1031709003620 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 1031709003621 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1031709003622 Flavoprotein; Region: Flavoprotein; pfam02441 1031709003623 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1031709003624 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1031709003625 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1031709003626 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1031709003627 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1031709003628 primosome assembly protein PriA; Provisional; Region: PRK14873 1031709003629 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1031709003630 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1031709003631 putative active site [active] 1031709003632 substrate binding site [chemical binding]; other site 1031709003633 putative cosubstrate binding site; other site 1031709003634 catalytic site [active] 1031709003635 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1031709003636 substrate binding site [chemical binding]; other site 1031709003637 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 1031709003638 putative RNA binding site [nucleotide binding]; other site 1031709003639 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1031709003640 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1031709003641 S-adenosylmethionine binding site [chemical binding]; other site 1031709003642 CAMP factor (Cfa); Region: CAMP_factor; pfam07373 1031709003643 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1031709003644 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1031709003645 substrate binding site [chemical binding]; other site 1031709003646 hexamer interface [polypeptide binding]; other site 1031709003647 metal binding site [ion binding]; metal-binding site 1031709003648 PAC2 family; Region: PAC2; pfam09754 1031709003649 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 1031709003650 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1031709003651 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1031709003652 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1031709003653 motif II; other site 1031709003654 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 1031709003655 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1031709003656 S-adenosylmethionine binding site [chemical binding]; other site 1031709003657 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 1031709003658 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1031709003659 Predicted membrane protein [Function unknown]; Region: COG1511 1031709003660 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1031709003661 ABC transporter; Region: ABC_tran; pfam00005 1031709003662 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1031709003663 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1031709003664 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1031709003665 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 1031709003666 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 1031709003667 active site 1031709003668 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 1031709003669 prephenate dehydrogenase; Validated; Region: PRK06545 1031709003670 prephenate dehydrogenase; Validated; Region: PRK08507 1031709003671 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cd02116 1031709003672 cytidylate kinase; Provisional; Region: cmk; PRK00023 1031709003673 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1031709003674 CMP-binding site; other site 1031709003675 GTP-binding protein Der; Reviewed; Region: PRK03003 1031709003676 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1031709003677 G1 box; other site 1031709003678 GTP/Mg2+ binding site [chemical binding]; other site 1031709003679 Switch I region; other site 1031709003680 G2 box; other site 1031709003681 Switch II region; other site 1031709003682 G3 box; other site 1031709003683 G4 box; other site 1031709003684 G5 box; other site 1031709003685 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1031709003686 G1 box; other site 1031709003687 GTP/Mg2+ binding site [chemical binding]; other site 1031709003688 Switch I region; other site 1031709003689 G2 box; other site 1031709003690 G3 box; other site 1031709003691 Switch II region; other site 1031709003692 G4 box; other site 1031709003693 G5 box; other site 1031709003694 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1031709003695 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1031709003696 substrate binding site [chemical binding]; other site 1031709003697 dimer interface [polypeptide binding]; other site 1031709003698 ATP binding site [chemical binding]; other site 1031709003699 deoxyribose mutarotase_like; Region: deoxyribose_mutarotase; cd09269 1031709003700 active site 1031709003701 catalytic residues [active] 1031709003702 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 1031709003703 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1031709003704 putative substrate translocation pore; other site 1031709003705 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1031709003706 intersubunit interface [polypeptide binding]; other site 1031709003707 active site 1031709003708 catalytic residue [active] 1031709003709 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1031709003710 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1031709003711 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1031709003712 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1031709003713 active site 1031709003714 motif I; other site 1031709003715 motif II; other site 1031709003716 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1031709003717 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 1031709003718 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1031709003719 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1031709003720 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1031709003721 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1031709003722 putative DNA binding site [nucleotide binding]; other site 1031709003723 putative Zn2+ binding site [ion binding]; other site 1031709003724 AsnC family; Region: AsnC_trans_reg; pfam01037 1031709003725 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 1031709003726 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1031709003727 putative active site [active] 1031709003728 catalytic triad [active] 1031709003729 putative dimer interface [polypeptide binding]; other site 1031709003730 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 1031709003731 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 1031709003732 Ligand binding site; other site 1031709003733 Putative Catalytic site; other site 1031709003734 DXD motif; other site 1031709003735 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 1031709003736 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 1031709003737 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 1031709003738 putative active site [active] 1031709003739 putative metal binding site [ion binding]; other site 1031709003740 catalytic site [active] 1031709003741 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 1031709003742 dimer interface [polypeptide binding]; other site 1031709003743 pyridoxamine kinase; Validated; Region: PRK05756 1031709003744 pyridoxal binding site [chemical binding]; other site 1031709003745 ATP binding site [chemical binding]; other site 1031709003746 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1031709003747 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1031709003748 non-specific DNA binding site [nucleotide binding]; other site 1031709003749 salt bridge; other site 1031709003750 sequence-specific DNA binding site [nucleotide binding]; other site 1031709003751 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1031709003752 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 1031709003753 putative active site [active] 1031709003754 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 1031709003755 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1031709003756 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1031709003757 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1031709003758 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1031709003759 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1031709003760 dimerization interface [polypeptide binding]; other site 1031709003761 putative DNA binding site [nucleotide binding]; other site 1031709003762 putative Zn2+ binding site [ion binding]; other site 1031709003763 CAMP factor (Cfa); Region: CAMP_factor; pfam07373 1031709003764 hypothetical protein; Provisional; Region: PRK09256 1031709003765 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1031709003766 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1031709003767 putative substrate translocation pore; other site 1031709003768 MarR family; Region: MarR; pfam01047 1031709003769 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 1031709003770 Fe-S cluster binding site [ion binding]; other site 1031709003771 DNA binding site [nucleotide binding] 1031709003772 active site 1031709003773 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 1031709003774 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 1031709003775 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1031709003776 gamma subunit interface [polypeptide binding]; other site 1031709003777 epsilon subunit interface [polypeptide binding]; other site 1031709003778 LBP interface [polypeptide binding]; other site 1031709003779 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1031709003780 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1031709003781 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1031709003782 alpha subunit interaction interface [polypeptide binding]; other site 1031709003783 Walker A motif; other site 1031709003784 ATP binding site [chemical binding]; other site 1031709003785 Walker B motif; other site 1031709003786 inhibitor binding site; inhibition site 1031709003787 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1031709003788 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1031709003789 core domain interface [polypeptide binding]; other site 1031709003790 delta subunit interface [polypeptide binding]; other site 1031709003791 epsilon subunit interface [polypeptide binding]; other site 1031709003792 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1031709003793 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1031709003794 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1031709003795 beta subunit interaction interface [polypeptide binding]; other site 1031709003796 Walker A motif; other site 1031709003797 ATP binding site [chemical binding]; other site 1031709003798 Walker B motif; other site 1031709003799 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1031709003800 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210 1031709003801 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1031709003802 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1031709003803 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1031709003804 F0F1 ATP synthase subunit C; Validated; Region: PRK07558 1031709003805 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1031709003806 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1031709003807 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 1031709003808 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1031709003809 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1031709003810 putative catalytic motif [active] 1031709003811 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1031709003812 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 1031709003813 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1031709003814 S-adenosylmethionine binding site [chemical binding]; other site 1031709003815 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1031709003816 PCRF domain; Region: PCRF; pfam03462 1031709003817 RF-1 domain; Region: RF-1; pfam00472 1031709003818 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1031709003819 transcription termination factor Rho; Provisional; Region: PRK12678 1031709003820 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1031709003821 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1031709003822 RNA binding site [nucleotide binding]; other site 1031709003823 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1031709003824 Walker A motif; other site 1031709003825 ATP binding site [chemical binding]; other site 1031709003826 Walker B motif; other site 1031709003827 homoserine kinase; Provisional; Region: PRK01212 1031709003828 threonine synthase; Reviewed; Region: PRK06721 1031709003829 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1031709003830 homodimer interface [polypeptide binding]; other site 1031709003831 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1031709003832 catalytic residue [active] 1031709003833 homoserine dehydrogenase; Provisional; Region: PRK06349 1031709003834 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1031709003835 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1031709003836 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1031709003837 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1031709003838 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1031709003839 active site 1031709003840 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1031709003841 substrate binding site [chemical binding]; other site 1031709003842 catalytic residues [active] 1031709003843 dimer interface [polypeptide binding]; other site 1031709003844 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 1031709003845 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1031709003846 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1031709003847 TPP-binding site [chemical binding]; other site 1031709003848 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1031709003849 Transcription factor WhiB; Region: Whib; pfam02467 1031709003850 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 1031709003851 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1031709003852 Histidine kinase; Region: HisKA_2; pfam07568 1031709003853 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1031709003854 ATP binding site [chemical binding]; other site 1031709003855 Mg2+ binding site [ion binding]; other site 1031709003856 G-X-G motif; other site 1031709003857 anti-sigma factor, TIGR02949 family; Region: anti_SigH_actin 1031709003858 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 1031709003859 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1031709003860 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1031709003861 DNA binding residues [nucleotide binding] 1031709003862 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1031709003863 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1031709003864 hinge; other site 1031709003865 active site 1031709003866 Predicted GTPases [General function prediction only]; Region: COG1162 1031709003867 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1031709003868 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1031709003869 GTP/Mg2+ binding site [chemical binding]; other site 1031709003870 G4 box; other site 1031709003871 G5 box; other site 1031709003872 G1 box; other site 1031709003873 Switch I region; other site 1031709003874 G2 box; other site 1031709003875 G3 box; other site 1031709003876 Switch II region; other site 1031709003877 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 1031709003878 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1031709003879 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 1031709003880 active site 1031709003881 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 1031709003882 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 1031709003883 ligand binding site [chemical binding]; other site 1031709003884 NAD binding site [chemical binding]; other site 1031709003885 tetramer interface [polypeptide binding]; other site 1031709003886 catalytic site [active] 1031709003887 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 1031709003888 L-serine binding site [chemical binding]; other site 1031709003889 ACT domain interface; other site 1031709003890 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1031709003891 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1031709003892 Walker A/P-loop; other site 1031709003893 ATP binding site [chemical binding]; other site 1031709003894 Q-loop/lid; other site 1031709003895 ABC transporter signature motif; other site 1031709003896 Walker B; other site 1031709003897 D-loop; other site 1031709003898 H-loop/switch region; other site 1031709003899 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1031709003900 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1031709003901 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1031709003902 Walker A/P-loop; other site 1031709003903 ATP binding site [chemical binding]; other site 1031709003904 Q-loop/lid; other site 1031709003905 ABC transporter signature motif; other site 1031709003906 Walker B; other site 1031709003907 D-loop; other site 1031709003908 H-loop/switch region; other site 1031709003909 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1031709003910 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1031709003911 dimer interface [polypeptide binding]; other site 1031709003912 conserved gate region; other site 1031709003913 putative PBP binding loops; other site 1031709003914 ABC-ATPase subunit interface; other site 1031709003915 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1031709003916 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1031709003917 dimer interface [polypeptide binding]; other site 1031709003918 conserved gate region; other site 1031709003919 putative PBP binding loops; other site 1031709003920 ABC-ATPase subunit interface; other site 1031709003921 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1031709003922 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 1031709003923 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1031709003924 sequence-specific DNA binding site [nucleotide binding]; other site 1031709003925 salt bridge; other site 1031709003926 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1031709003927 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1031709003928 P-loop; other site 1031709003929 Magnesium ion binding site [ion binding]; other site 1031709003930 Domain of unknown function (DUF929); Region: DUF929; pfam06053 1031709003931 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1031709003932 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1031709003933 AMP-binding enzyme; Region: AMP-binding; pfam00501 1031709003934 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1031709003935 AMP binding site [chemical binding]; other site 1031709003936 active site 1031709003937 acyl-activating enzyme (AAE) consensus motif; other site 1031709003938 CoA binding site [chemical binding]; other site 1031709003939 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1031709003940 Condensation domain; Region: Condensation; pfam00668 1031709003941 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1031709003942 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1031709003943 2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944 1031709003944 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1031709003945 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 1031709003946 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1031709003947 dimer interface [polypeptide binding]; other site 1031709003948 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1031709003949 catalytic residue [active] 1031709003950 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1031709003951 ParB-like nuclease domain; Region: ParBc; cl02129 1031709003952 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1031709003953 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 1031709003954 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 1031709003955 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 1031709003956 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1031709003957 Ligand Binding Site [chemical binding]; other site 1031709003958 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 1031709003959 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1031709003960 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1031709003961 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 1031709003962 Protein of unknown function DUF45; Region: DUF45; pfam01863 1031709003963 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1031709003964 Part of AAA domain; Region: AAA_19; pfam13245 1031709003965 Family description; Region: UvrD_C_2; pfam13538 1031709003966 HRDC domain; Region: HRDC; pfam00570 1031709003967 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 1031709003968 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 1031709003969 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 1031709003970 Part of AAA domain; Region: AAA_19; pfam13245 1031709003971 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1031709003972 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 1031709003973 AAA domain; Region: AAA_30; pfam13604 1031709003974 Family description; Region: UvrD_C_2; pfam13538 1031709003975 potential frameshift: common BLAST hit: gi|365974184|ref|YP_004955743.1| NUDIX family hydrolase 1031709003976 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1031709003977 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1031709003978 putative NADH binding site [chemical binding]; other site 1031709003979 putative active site [active] 1031709003980 nudix motif; other site 1031709003981 putative metal binding site [ion binding]; other site 1031709003982 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1031709003983 Part of AAA domain; Region: AAA_19; pfam13245 1031709003984 Family description; Region: UvrD_C_2; pfam13538 1031709003985 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1031709003986 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1031709003987 Part of AAA domain; Region: AAA_19; pfam13245 1031709003988 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1031709003989 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1031709003990 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 1031709003991 active site 1031709003992 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 1031709003993 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 1031709003994 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1031709003995 ATP binding site [chemical binding]; other site 1031709003996 Mg++ binding site [ion binding]; other site 1031709003997 motif III; other site 1031709003998 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1031709003999 nucleotide binding region [chemical binding]; other site 1031709004000 ATP-binding site [chemical binding]; other site 1031709004001 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1031709004002 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1031709004003 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1031709004004 active site 1031709004005 HIGH motif; other site 1031709004006 dimer interface [polypeptide binding]; other site 1031709004007 KMSKS motif; other site 1031709004008 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 1031709004009 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1031709004010 active site 1031709004011 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1031709004012 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 1031709004013 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 1031709004014 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1031709004015 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1031709004016 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1031709004017 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1031709004018 30S subunit binding site; other site 1031709004019 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1031709004020 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1031709004021 active site 1031709004022 Sporulation and spore germination; Region: Germane; pfam10646 1031709004023 Lipoprotein LpqB beta-propeller domain; Region: Gmad1; pfam10647 1031709004024 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1031709004025 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1031709004026 dimerization interface [polypeptide binding]; other site 1031709004027 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1031709004028 dimer interface [polypeptide binding]; other site 1031709004029 phosphorylation site [posttranslational modification] 1031709004030 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1031709004031 ATP binding site [chemical binding]; other site 1031709004032 Mg2+ binding site [ion binding]; other site 1031709004033 G-X-G motif; other site 1031709004034 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1031709004035 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1031709004036 active site 1031709004037 phosphorylation site [posttranslational modification] 1031709004038 intermolecular recognition site; other site 1031709004039 dimerization interface [polypeptide binding]; other site 1031709004040 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1031709004041 DNA binding site [nucleotide binding] 1031709004042 hypothetical protein; Validated; Region: PRK00228 1031709004043 CAMP factor (Cfa); Region: CAMP_factor; pfam07373 1031709004044 ribbon-helix-helix domain containing protein; Region: PHA00617 1031709004045 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 1031709004046 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1031709004047 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1031709004048 Tic20-like protein; Region: Tic20; pfam09685 1031709004049 argininosuccinate lyase; Provisional; Region: PRK00855 1031709004050 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1031709004051 active sites [active] 1031709004052 tetramer interface [polypeptide binding]; other site 1031709004053 potential frameshift: common BLAST hit: gi|50842831|ref|YP_056058.1| acetylornithine aminotransferase 1031709004054 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 1031709004055 feedback inhibition sensing region; other site 1031709004056 homohexameric interface [polypeptide binding]; other site 1031709004057 nucleotide binding site [chemical binding]; other site 1031709004058 N-acetyl-L-glutamate binding site [chemical binding]; other site 1031709004059 DmpA/OAT superfamily; composed of L-aminopeptidase D-amidase/D-esterase (DmpA), ornithine acetyltransferase (OAT) and similar proteins. DmpA is an aminopeptidase that releases N-terminal D and L amino acids from peptide substrates. This group represents...; Region: DmpA_OAT; cl00603 1031709004060 DmpA/OAT superfamily; composed of L-aminopeptidase D-amidase/D-esterase (DmpA), ornithine acetyltransferase (OAT) and similar proteins. DmpA is an aminopeptidase that releases N-terminal D and L amino acids from peptide substrates. This group represents...; Region: DmpA_OAT; cl00603 1031709004061 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1031709004062 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1031709004063 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1031709004064 SmpB-tmRNA interface; other site 1031709004065 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1031709004066 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1031709004067 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1031709004068 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1031709004069 Walker A/P-loop; other site 1031709004070 ATP binding site [chemical binding]; other site 1031709004071 Q-loop/lid; other site 1031709004072 ABC transporter signature motif; other site 1031709004073 Walker B; other site 1031709004074 D-loop; other site 1031709004075 H-loop/switch region; other site 1031709004076 peptide chain release factor 2; Validated; Region: prfB; PRK00578 1031709004077 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1031709004078 RF-1 domain; Region: RF-1; pfam00472 1031709004079 Protein of unknown function (DUF805); Region: DUF805; pfam05656 1031709004080 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1031709004081 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1031709004082 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1031709004083 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1031709004084 thiamine monophosphate kinase; Provisional; Region: PRK05731 1031709004085 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1031709004086 ATP binding site [chemical binding]; other site 1031709004087 dimerization interface [polypeptide binding]; other site 1031709004088 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 1031709004089 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1031709004090 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1031709004091 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1031709004092 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1031709004093 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1031709004094 putative acyl-acceptor binding pocket; other site 1031709004095 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1031709004096 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1031709004097 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1031709004098 Bacterial transcriptional regulator; Region: IclR; pfam01614 1031709004099 CAAX protease self-immunity; Region: Abi; pfam02517 1031709004100 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 1031709004101 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1031709004102 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1031709004103 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 1031709004104 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1031709004105 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1031709004106 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 1031709004107 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1031709004108 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1031709004109 homodimer interface [polypeptide binding]; other site 1031709004110 substrate-cofactor binding pocket; other site 1031709004111 catalytic residue [active] 1031709004112 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 1031709004113 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 1031709004114 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1031709004115 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1031709004116 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1031709004117 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1031709004118 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1031709004119 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1031709004120 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1031709004121 HIT family signature motif; other site 1031709004122 catalytic residue [active] 1031709004123 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1031709004124 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1031709004125 substrate binding site [chemical binding]; other site 1031709004126 glutamase interaction surface [polypeptide binding]; other site 1031709004127 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 1031709004128 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1031709004129 ATP binding site [chemical binding]; other site 1031709004130 putative Mg++ binding site [ion binding]; other site 1031709004131 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1031709004132 nucleotide binding region [chemical binding]; other site 1031709004133 ATP-binding site [chemical binding]; other site 1031709004134 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 1031709004135 Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902 1031709004136 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 1031709004137 Predicted transcriptional regulator [Transcription]; Region: COG2378 1031709004138 WYL domain; Region: WYL; pfam13280 1031709004139 Predicted transcriptional regulator [Transcription]; Region: COG2378 1031709004140 WYL domain; Region: WYL; pfam13280 1031709004141 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1031709004142 active site 1031709004143 HIGH motif; other site 1031709004144 nucleotide binding site [chemical binding]; other site 1031709004145 active site 1031709004146 KMSKS motif; other site 1031709004147 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1031709004148 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1031709004149 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1031709004150 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1031709004151 RNA binding surface [nucleotide binding]; other site 1031709004152 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1031709004153 active site 1031709004154 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1031709004155 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1031709004156 P-loop; other site 1031709004157 Magnesium ion binding site [ion binding]; other site 1031709004158 transport-energizing ATPase, TRC40/GET3/ArsA family; Region: GET3_arsA_TRC40; TIGR00345 1031709004159 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1031709004160 Magnesium ion binding site [ion binding]; other site 1031709004161 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1031709004162 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1031709004163 active site 1031709004164 Int/Topo IB signature motif; other site 1031709004165 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1031709004166 dimer interface [polypeptide binding]; other site 1031709004167 ADP-ribose binding site [chemical binding]; other site 1031709004168 active site 1031709004169 nudix motif; other site 1031709004170 metal binding site [ion binding]; metal-binding site 1031709004171 CTP synthetase; Validated; Region: pyrG; PRK05380 1031709004172 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1031709004173 Catalytic site [active] 1031709004174 active site 1031709004175 UTP binding site [chemical binding]; other site 1031709004176 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1031709004177 active site 1031709004178 putative oxyanion hole; other site 1031709004179 catalytic triad [active] 1031709004180 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1031709004181 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1031709004182 Walker A/P-loop; other site 1031709004183 ATP binding site [chemical binding]; other site 1031709004184 Q-loop/lid; other site 1031709004185 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1031709004186 ABC transporter signature motif; other site 1031709004187 Walker B; other site 1031709004188 D-loop; other site 1031709004189 H-loop/switch region; other site 1031709004190 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 1031709004191 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1031709004192 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1031709004193 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1031709004194 RNA binding surface [nucleotide binding]; other site 1031709004195 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1031709004196 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1031709004197 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1031709004198 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1031709004199 Walker A/P-loop; other site 1031709004200 ATP binding site [chemical binding]; other site 1031709004201 Q-loop/lid; other site 1031709004202 ABC transporter signature motif; other site 1031709004203 Walker B; other site 1031709004204 D-loop; other site 1031709004205 H-loop/switch region; other site 1031709004206 BioY family; Region: BioY; pfam02632 1031709004207 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1031709004208 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1031709004209 active site 1031709004210 motif I; other site 1031709004211 motif II; other site 1031709004212 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1031709004213 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1031709004214 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1031709004215 TPR motif; other site 1031709004216 binding surface 1031709004217 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1031709004218 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1031709004219 active site 1031709004220 HIGH motif; other site 1031709004221 dimer interface [polypeptide binding]; other site 1031709004222 KMSKS motif; other site 1031709004223 arginine repressor; Provisional; Region: PRK03341 1031709004224 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1031709004225 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1031709004226 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1031709004227 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1031709004228 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1031709004229 biotin synthase; Validated; Region: PRK06256 1031709004230 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1031709004231 FeS/SAM binding site; other site 1031709004232 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1031709004233 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1031709004234 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1031709004235 putative tRNA-binding site [nucleotide binding]; other site 1031709004236 B3/4 domain; Region: B3_4; pfam03483 1031709004237 tRNA synthetase B5 domain; Region: B5; pfam03484 1031709004238 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1031709004239 dimer interface [polypeptide binding]; other site 1031709004240 motif 1; other site 1031709004241 motif 3; other site 1031709004242 motif 2; other site 1031709004243 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1031709004244 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1031709004245 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1031709004246 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1031709004247 dimer interface [polypeptide binding]; other site 1031709004248 motif 1; other site 1031709004249 active site 1031709004250 motif 2; other site 1031709004251 motif 3; other site 1031709004252 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1031709004253 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 1031709004254 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1031709004255 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1031709004256 23S rRNA binding site [nucleotide binding]; other site 1031709004257 L21 binding site [polypeptide binding]; other site 1031709004258 L13 binding site [polypeptide binding]; other site 1031709004259 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1031709004260 translation initiation factor IF-3; Region: infC; TIGR00168 1031709004261 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1031709004262 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1031709004263 Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126 1031709004264 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 1031709004265 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 1031709004266 HisG, C-terminal domain; Region: HisG_C; pfam08029 1031709004267 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 1031709004268 homodimer interface [polypeptide binding]; other site 1031709004269 putative metal binding site [ion binding]; other site 1031709004270 Nicotinamide mononucleotide transporter [Coenzyme metabolism]; Region: PnuC; COG3201 1031709004271 conserved hypothetical protein; Region: TIGR03843 1031709004272 conserved hypothetical protein; Region: TIGR03847 1031709004273 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1031709004274 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1031709004275 active site 1031709004276 catalytic tetrad [active] 1031709004277 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1031709004278 dimer interface [polypeptide binding]; other site 1031709004279 Citrate synthase; Region: Citrate_synt; pfam00285 1031709004280 active site 1031709004281 citrylCoA binding site [chemical binding]; other site 1031709004282 NADH binding [chemical binding]; other site 1031709004283 cationic pore residues; other site 1031709004284 oxalacetate/citrate binding site [chemical binding]; other site 1031709004285 coenzyme A binding site [chemical binding]; other site 1031709004286 catalytic triad [active] 1031709004287 hypothetical protein; Provisional; Region: PRK07906 1031709004288 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 1031709004289 putative metal binding site [ion binding]; other site 1031709004290 acid shock protein precursor; Provisional; Region: PRK03577 1031709004291 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1031709004292 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1031709004293 CsbD-like; Region: CsbD; pfam05532 1031709004294 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1031709004295 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1031709004296 DNA binding site [nucleotide binding] 1031709004297 active site 1031709004298 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1031709004299 DNA protecting protein DprA; Region: dprA; TIGR00732 1031709004300 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1031709004301 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1031709004302 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1031709004303 Walker A motif; other site 1031709004304 ATP binding site [chemical binding]; other site 1031709004305 Walker B motif; other site 1031709004306 arginine finger; other site 1031709004307 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1031709004308 hypothetical protein; Reviewed; Region: PRK12497 1031709004309 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 1031709004310 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1031709004311 RNA/DNA hybrid binding site [nucleotide binding]; other site 1031709004312 active site 1031709004313 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1031709004314 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1031709004315 Catalytic site [active] 1031709004316 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1031709004317 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 1031709004318 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1031709004319 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1031709004320 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 1031709004321 L-aspartate oxidase; Provisional; Region: PRK06175 1031709004322 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1031709004323 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 1031709004324 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 1031709004325 proximal heme binding site [chemical binding]; other site 1031709004326 distal heme binding site [chemical binding]; other site 1031709004327 putative dimer interface [polypeptide binding]; other site 1031709004328 putative Iron-sulfur protein interface [polypeptide binding]; other site 1031709004329 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1031709004330 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1031709004331 RimM N-terminal domain; Region: RimM; pfam01782 1031709004332 PRC-barrel domain; Region: PRC; pfam05239 1031709004333 hypothetical protein; Provisional; Region: PRK02821 1031709004334 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1031709004335 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 1031709004336 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1031709004337 Amidohydrolase; Region: Amidohydro_4; pfam13147 1031709004338 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1031709004339 active site 1031709004340 signal recognition particle protein; Provisional; Region: PRK10867 1031709004341 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1031709004342 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1031709004343 P loop; other site 1031709004344 GTP binding site [chemical binding]; other site 1031709004345 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1031709004346 Predicted esterase [General function prediction only]; Region: COG0627 1031709004347 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 1031709004348 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1031709004349 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1031709004350 P loop; other site 1031709004351 GTP binding site [chemical binding]; other site 1031709004352 Predicted membrane protein [Function unknown]; Region: COG2246 1031709004353 GtrA-like protein; Region: GtrA; pfam04138 1031709004354 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 1031709004355 HicB family; Region: HicB; pfam05534 1031709004356 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1031709004357 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1031709004358 DNA binding site [nucleotide binding] 1031709004359 catalytic residue [active] 1031709004360 H2TH interface [polypeptide binding]; other site 1031709004361 putative catalytic residues [active] 1031709004362 turnover-facilitating residue; other site 1031709004363 intercalation triad [nucleotide binding]; other site 1031709004364 8OG recognition residue [nucleotide binding]; other site 1031709004365 putative reading head residues; other site 1031709004366 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1031709004367 ribonuclease III; Reviewed; Region: rnc; PRK00102 1031709004368 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1031709004369 dimerization interface [polypeptide binding]; other site 1031709004370 active site 1031709004371 metal binding site [ion binding]; metal-binding site 1031709004372 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1031709004373 dsRNA binding site [nucleotide binding]; other site 1031709004374 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 1031709004375 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 1031709004376 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1031709004377 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1031709004378 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1031709004379 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1031709004380 dimer interface [polypeptide binding]; other site 1031709004381 conserved gate region; other site 1031709004382 putative PBP binding loops; other site 1031709004383 ABC-ATPase subunit interface; other site 1031709004384 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1031709004385 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1031709004386 dimer interface [polypeptide binding]; other site 1031709004387 conserved gate region; other site 1031709004388 putative PBP binding loops; other site 1031709004389 ABC-ATPase subunit interface; other site 1031709004390 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1031709004391 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1031709004392 DNA binding site [nucleotide binding] 1031709004393 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1031709004394 ligand binding site [chemical binding]; other site 1031709004395 dimerization interface [polypeptide binding]; other site 1031709004396 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 1031709004397 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 1031709004398 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 1031709004399 active site 1031709004400 catalytic site [active] 1031709004401 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; pfam09261 1031709004402 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1031709004403 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1031709004404 active site 1031709004405 (T/H)XGH motif; other site 1031709004406 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 1031709004407 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1031709004408 S-adenosylmethionine binding site [chemical binding]; other site 1031709004409 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 1031709004410 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1031709004411 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1031709004412 ssDNA binding site; other site 1031709004413 generic binding surface II; other site 1031709004414 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1031709004415 ATP binding site [chemical binding]; other site 1031709004416 putative Mg++ binding site [ion binding]; other site 1031709004417 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1031709004418 nucleotide binding region [chemical binding]; other site 1031709004419 ATP-binding site [chemical binding]; other site 1031709004420 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1031709004421 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1031709004422 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1031709004423 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1031709004424 pyruvate dehydrogenase; Provisional; Region: PRK06546 1031709004425 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1031709004426 PYR/PP interface [polypeptide binding]; other site 1031709004427 dimer interface [polypeptide binding]; other site 1031709004428 tetramer interface [polypeptide binding]; other site 1031709004429 TPP binding site [chemical binding]; other site 1031709004430 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1031709004431 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1031709004432 TPP-binding site [chemical binding]; other site 1031709004433 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1031709004434 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1031709004435 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1031709004436 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1031709004437 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 1031709004438 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 1031709004439 oligomer interface [polypeptide binding]; other site 1031709004440 RNA binding site [nucleotide binding]; other site 1031709004441 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1031709004442 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1031709004443 RNase E interface [polypeptide binding]; other site 1031709004444 trimer interface [polypeptide binding]; other site 1031709004445 active site 1031709004446 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1031709004447 putative nucleic acid binding region [nucleotide binding]; other site 1031709004448 G-X-X-G motif; other site 1031709004449 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1031709004450 RNA binding site [nucleotide binding]; other site 1031709004451 domain interface; other site 1031709004452 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1031709004453 16S/18S rRNA binding site [nucleotide binding]; other site 1031709004454 S13e-L30e interaction site [polypeptide binding]; other site 1031709004455 25S rRNA binding site [nucleotide binding]; other site 1031709004456 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1031709004457 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1031709004458 active site 1031709004459 Riboflavin kinase; Region: Flavokinase; smart00904 1031709004460 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1031709004461 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1031709004462 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 1031709004463 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1031709004464 dimer interface [polypeptide binding]; other site 1031709004465 conserved gate region; other site 1031709004466 ABC-ATPase subunit interface; other site 1031709004467 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 1031709004468 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1031709004469 Walker A/P-loop; other site 1031709004470 ATP binding site [chemical binding]; other site 1031709004471 Q-loop/lid; other site 1031709004472 ABC transporter signature motif; other site 1031709004473 Walker B; other site 1031709004474 D-loop; other site 1031709004475 H-loop/switch region; other site 1031709004476 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1031709004477 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 1031709004478 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1031709004479 RNA binding site [nucleotide binding]; other site 1031709004480 active site 1031709004481 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 1031709004482 Cupin domain; Region: Cupin_2; cl17218 1031709004483 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1031709004484 HTH domain; Region: HTH_11; pfam08279 1031709004485 HTH domain; Region: HTH_11; pfam08279 1031709004486 PRD domain; Region: PRD; pfam00874 1031709004487 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 1031709004488 active site 1031709004489 P-loop; other site 1031709004490 phosphorylation site [posttranslational modification] 1031709004491 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359 1031709004492 active site 1031709004493 phosphorylation site [posttranslational modification] 1031709004494 Glucitol operon activator protein (GutM); Region: GutM; pfam06923 1031709004495 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; pfam03608 1031709004496 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 1031709004497 PTS system, glucitol/sorbitol-specific, IIBC component; Region: EIIBC-GUT; TIGR00825 1031709004498 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 1031709004499 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829 1031709004500 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1031709004501 dimerization domain swap beta strand [polypeptide binding]; other site 1031709004502 regulatory protein interface [polypeptide binding]; other site 1031709004503 active site 1031709004504 regulatory phosphorylation site [posttranslational modification]; other site 1031709004505 Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175 1031709004506 active site 1031709004507 metal binding site [ion binding]; metal-binding site 1031709004508 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1031709004509 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1031709004510 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1031709004511 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 1031709004512 Walker A/P-loop; other site 1031709004513 ATP binding site [chemical binding]; other site 1031709004514 Q-loop/lid; other site 1031709004515 ABC transporter signature motif; other site 1031709004516 Walker B; other site 1031709004517 D-loop; other site 1031709004518 H-loop/switch region; other site 1031709004519 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1031709004520 translation initiation factor IF-2; Region: IF-2; TIGR00487 1031709004521 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1031709004522 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1031709004523 G1 box; other site 1031709004524 putative GEF interaction site [polypeptide binding]; other site 1031709004525 GTP/Mg2+ binding site [chemical binding]; other site 1031709004526 Switch I region; other site 1031709004527 G2 box; other site 1031709004528 G3 box; other site 1031709004529 Switch II region; other site 1031709004530 G4 box; other site 1031709004531 G5 box; other site 1031709004532 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1031709004533 Translation-initiation factor 2; Region: IF-2; pfam11987 1031709004534 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1031709004535 Protein of unknown function (DUF448); Region: DUF448; pfam04296 1031709004536 putative RNA binding cleft [nucleotide binding]; other site 1031709004537 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1031709004538 NusA N-terminal domain; Region: NusA_N; pfam08529 1031709004539 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1031709004540 RNA binding site [nucleotide binding]; other site 1031709004541 homodimer interface [polypeptide binding]; other site 1031709004542 NusA-like KH domain; Region: KH_5; pfam13184 1031709004543 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1031709004544 G-X-X-G motif; other site 1031709004545 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1031709004546 Sm and related proteins; Region: Sm_like; cl00259 1031709004547 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1031709004548 putative oligomer interface [polypeptide binding]; other site 1031709004549 putative RNA binding site [nucleotide binding]; other site 1031709004550 hypothetical protein; Provisional; Region: PRK10621 1031709004551 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1031709004552 metallophosphoesterase, PPA1498 family; Region: P_acnes_RR; TIGR03767 1031709004553 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1031709004554 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1031709004555 dimer interface [polypeptide binding]; other site 1031709004556 motif 1; other site 1031709004557 active site 1031709004558 motif 2; other site 1031709004559 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1031709004560 putative deacylase active site [active] 1031709004561 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1031709004562 active site 1031709004563 motif 3; other site 1031709004564 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1031709004565 anticodon binding site; other site 1031709004566 putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773 1031709004567 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 1031709004568 putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773 1031709004569 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 1031709004570 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 1031709004571 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1031709004572 anchored repeat ABC transporter, substrate-binding protein; Region: anch_rpt_subst; TIGR03772 1031709004573 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 1031709004574 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1031709004575 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 1031709004576 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1031709004577 anchored repeat-type ABC transporter, ATP-binding subunit; Region: anch_rpt_ABC; TIGR03771 1031709004578 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1031709004579 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1031709004580 ABC-ATPase subunit interface; other site 1031709004581 dimer interface [polypeptide binding]; other site 1031709004582 putative PBP binding regions; other site 1031709004583 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 1031709004584 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1031709004585 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1031709004586 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1031709004587 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1031709004588 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 1031709004589 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1031709004590 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 1031709004591 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1031709004592 active site 1031709004593 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1031709004594 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1031709004595 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1031709004596 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1031709004597 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1031709004598 Beta-lactamase; Region: Beta-lactamase; pfam00144 1031709004599 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1031709004600 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1031709004601 glutamate dehydrogenase; Provisional; Region: PRK09414 1031709004602 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1031709004603 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 1031709004604 NAD(P) binding site [chemical binding]; other site 1031709004605 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 1031709004606 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1031709004607 FeS/SAM binding site; other site 1031709004608 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 1031709004609 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1031709004610 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1031709004611 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1031709004612 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1031709004613 hinge region; other site 1031709004614 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1031709004615 putative nucleotide binding site [chemical binding]; other site 1031709004616 uridine monophosphate binding site [chemical binding]; other site 1031709004617 homohexameric interface [polypeptide binding]; other site 1031709004618 elongation factor Ts; Provisional; Region: tsf; PRK09377 1031709004619 UBA/TS-N domain; Region: UBA; pfam00627 1031709004620 Elongation factor TS; Region: EF_TS; pfam00889 1031709004621 Elongation factor TS; Region: EF_TS; pfam00889 1031709004622 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1031709004623 rRNA interaction site [nucleotide binding]; other site 1031709004624 S8 interaction site; other site 1031709004625 putative laminin-1 binding site; other site 1031709004626 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1031709004627 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1031709004628 active site 1031709004629 DNA binding site [nucleotide binding] 1031709004630 Int/Topo IB signature motif; other site 1031709004631 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 1031709004632 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1031709004633 active site 1031709004634 catalytic residues [active] 1031709004635 metal binding site [ion binding]; metal-binding site 1031709004636 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1031709004637 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1031709004638 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1031709004639 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 1031709004640 potential frameshift: common BLAST hit: gi|295131077|ref|YP_003581740.1| Putative stomatin/prohibitin-family membrane protease subunit YbbK 1031709004641 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1031709004642 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1031709004643 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 1031709004644 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 1031709004645 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1031709004646 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1031709004647 Walker A/P-loop; other site 1031709004648 ATP binding site [chemical binding]; other site 1031709004649 Q-loop/lid; other site 1031709004650 ABC transporter signature motif; other site 1031709004651 Walker B; other site 1031709004652 D-loop; other site 1031709004653 H-loop/switch region; other site 1031709004654 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 1031709004655 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1031709004656 NAD(P) binding site [chemical binding]; other site 1031709004657 active site 1031709004658 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1031709004659 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1031709004660 NAD(P) binding site [chemical binding]; other site 1031709004661 active site 1031709004662 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 1031709004663 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 1031709004664 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 1031709004665 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1031709004666 S-adenosylmethionine binding site [chemical binding]; other site 1031709004667 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1031709004668 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1031709004669 Walker A/P-loop; other site 1031709004670 ATP binding site [chemical binding]; other site 1031709004671 Q-loop/lid; other site 1031709004672 ABC transporter signature motif; other site 1031709004673 Walker B; other site 1031709004674 D-loop; other site 1031709004675 H-loop/switch region; other site 1031709004676 ABC transporter; Region: ABC_tran_2; pfam12848 1031709004677 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1031709004678 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1031709004679 Coenzyme A binding pocket [chemical binding]; other site 1031709004680 potential frameshift: common BLAST hit: gi|295131091|ref|YP_003581754.1| pyridine nucleotide-disulfide oxidoreductase 1031709004681 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1031709004682 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1031709004683 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1031709004684 trimerization site [polypeptide binding]; other site 1031709004685 active site 1031709004686 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1031709004687 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1031709004688 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1031709004689 catalytic residue [active] 1031709004690 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1031709004691 FeS assembly ATPase SufC; Region: sufC; TIGR01978 1031709004692 Walker A/P-loop; other site 1031709004693 ATP binding site [chemical binding]; other site 1031709004694 Q-loop/lid; other site 1031709004695 ABC transporter signature motif; other site 1031709004696 Walker B; other site 1031709004697 D-loop; other site 1031709004698 H-loop/switch region; other site 1031709004699 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 1031709004700 [2Fe-2S] cluster binding site [ion binding]; other site 1031709004701 FeS assembly protein SufD; Region: sufD; TIGR01981 1031709004702 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 1031709004703 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1031709004704 FeS assembly protein SufB; Region: sufB; TIGR01980 1031709004705 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1031709004706 dimerization interface [polypeptide binding]; other site 1031709004707 putative DNA binding site [nucleotide binding]; other site 1031709004708 Predicted transcriptional regulator [Transcription]; Region: COG2345 1031709004709 putative Zn2+ binding site [ion binding]; other site 1031709004710 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 1031709004711 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1031709004712 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1031709004713 dimer interface [polypeptide binding]; other site 1031709004714 conserved gate region; other site 1031709004715 putative PBP binding loops; other site 1031709004716 ABC-ATPase subunit interface; other site 1031709004717 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1031709004718 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1031709004719 dimer interface [polypeptide binding]; other site 1031709004720 conserved gate region; other site 1031709004721 putative PBP binding loops; other site 1031709004722 ABC-ATPase subunit interface; other site 1031709004723 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1031709004724 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1031709004725 DNA binding site [nucleotide binding] 1031709004726 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_10; cd06292 1031709004727 putative dimerization interface [polypeptide binding]; other site 1031709004728 putative ligand binding site [chemical binding]; other site 1031709004729 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 1031709004730 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 1031709004731 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1031709004732 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1031709004733 Walker A/P-loop; other site 1031709004734 ATP binding site [chemical binding]; other site 1031709004735 Q-loop/lid; other site 1031709004736 ABC transporter signature motif; other site 1031709004737 Walker B; other site 1031709004738 D-loop; other site 1031709004739 H-loop/switch region; other site 1031709004740 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1031709004741 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1031709004742 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1031709004743 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1031709004744 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 1031709004745 catalytic site [active] 1031709004746 BNR repeat-like domain; Region: BNR_2; pfam13088 1031709004747 Asp-box motif; other site 1031709004748 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1031709004749 UbiA prenyltransferase family; Region: UbiA; pfam01040 1031709004750 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1031709004751 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1031709004752 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1031709004753 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 1031709004754 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 1031709004755 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1031709004756 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 1031709004757 putative active site [active] 1031709004758 DoxX; Region: DoxX; pfam07681 1031709004759 Thioredoxin; Region: Thioredoxin_4; cl17273 1031709004760 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1031709004761 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208 1031709004762 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1031709004763 active site 1031709004764 HIGH motif; other site 1031709004765 nucleotide binding site [chemical binding]; other site 1031709004766 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1031709004767 active site 1031709004768 KMSKS motif; other site 1031709004769 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1031709004770 tRNA binding surface [nucleotide binding]; other site 1031709004771 anticodon binding site; other site 1031709004772 potential frameshift: common BLAST hit: gi|295131118|ref|YP_003581781.1| F5/8 type C domain protein 1031709004773 Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown]; Region: COG4946 1031709004774 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1031709004775 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1031709004776 Orbivirus outer capsid protein VP2; Region: Orbi_VP2; pfam00898 1031709004777 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 1031709004778 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1031709004779 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1031709004780 protein binding site [polypeptide binding]; other site 1031709004781 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 1031709004782 Domain interface; other site 1031709004783 Peptide binding site; other site 1031709004784 Active site tetrad [active] 1031709004785 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1031709004786 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1031709004787 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1031709004788 Walker A motif; other site 1031709004789 ATP binding site [chemical binding]; other site 1031709004790 Walker B motif; other site 1031709004791 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1031709004792 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 1031709004793 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1031709004794 oligomer interface [polypeptide binding]; other site 1031709004795 active site residues [active] 1031709004796 Clp protease; Region: CLP_protease; pfam00574 1031709004797 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1031709004798 oligomer interface [polypeptide binding]; other site 1031709004799 active site residues [active] 1031709004800 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1031709004801 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1031709004802 trigger factor; Provisional; Region: tig; PRK01490 1031709004803 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1031709004804 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1031709004805 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 1031709004806 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1031709004807 ATP binding site [chemical binding]; other site 1031709004808 putative Mg++ binding site [ion binding]; other site 1031709004809 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1031709004810 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1031709004811 nucleotide binding region [chemical binding]; other site 1031709004812 ATP-binding site [chemical binding]; other site 1031709004813 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1031709004814 conserved cys residue [active] 1031709004815 potential frameshift: common BLAST hit: gi|297572093|ref|YP_003697867.1| terminase 1031709004816 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1031709004817 ParB-like nuclease domain; Region: ParBc; pfam02195 1031709004818 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1031709004819 DNA methylase; Region: N6_N4_Mtase; pfam01555 1031709004820 S-adenosylmethionine synthetase; Provisional; Region: PRK12459 1031709004821 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1031709004822 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1031709004823 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1031709004824 Phage terminase, small subunit; Region: Terminase_4; cl01525 1031709004825 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1031709004826 BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418 1031709004827 active site 1031709004828 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1031709004829 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1031709004830 active site 1031709004831 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1031709004832 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 1031709004833 VRR-NUC domain; Region: VRR_NUC; pfam08774 1031709004834 Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942 1031709004835 D5 N terminal like; Region: D5_N; pfam08706 1031709004836 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 1031709004837 Prophage antirepressor [Transcription]; Region: COG3617 1031709004838 BRO family, N-terminal domain; Region: Bro-N; smart01040 1031709004839 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 1031709004840 Abi-like protein; Region: Abi_2; cl01988 1031709004841 potential frameshift: common BLAST hit: gi|153955279|ref|YP_001396044.1| Phage-related DNA polymerase 1031709004842 Cytochrome C biogenesis protein; Region: CcmH; cl01179 1031709004843 Protein of unknown function (DUF2815); Region: DUF2815; pfam10991 1031709004844 Protein of unknown function (DUF2800); Region: DUF2800; pfam10926 1031709004845 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1031709004846 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1031709004847 DNA binding residues [nucleotide binding] 1031709004848 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1031709004849 AAA domain; Region: AAA_23; pfam13476 1031709004850 Walker A/P-loop; other site 1031709004851 ATP binding site [chemical binding]; other site 1031709004852 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1031709004853 non-specific DNA binding site [nucleotide binding]; other site 1031709004854 salt bridge; other site 1031709004855 sequence-specific DNA binding site [nucleotide binding]; other site 1031709004856 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 1031709004857 DNA methylase; Region: N6_N4_Mtase; pfam01555 1031709004858 DNA methylase; Region: N6_N4_Mtase; pfam01555 1031709004859 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 1031709004860 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1031709004861 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1031709004862 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1031709004863 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 1031709004864 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1031709004865 ATP binding site [chemical binding]; other site 1031709004866 putative Mg++ binding site [ion binding]; other site 1031709004867 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1031709004868 ATP-binding site [chemical binding]; other site 1031709004869 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1031709004870 Part of AAA domain; Region: AAA_19; pfam13245 1031709004871 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1031709004872 Family description; Region: UvrD_C_2; pfam13538 1031709004873 The HIRAN protein (HIP116, Rad5p N-terminal) is found in the N-terminal regions of the SWI2/SNF2 proteins typified by HIP116 and Rad5p; Region: HIRAN; smart00910 1031709004874 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1031709004875 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 1031709004876 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1031709004877 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1031709004878 dimer interface [polypeptide binding]; other site 1031709004879 putative anticodon binding site; other site 1031709004880 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1031709004881 motif 1; other site 1031709004882 dimer interface [polypeptide binding]; other site 1031709004883 active site 1031709004884 motif 2; other site 1031709004885 motif 3; other site 1031709004886 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1031709004887 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 1031709004888 putative DNA binding site [nucleotide binding]; other site 1031709004889 catalytic residue [active] 1031709004890 putative H2TH interface [polypeptide binding]; other site 1031709004891 putative catalytic residues [active] 1031709004892 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1031709004893 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1031709004894 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 1031709004895 hypothetical protein; Provisional; Region: PRK01346 1031709004896 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1031709004897 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1031709004898 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1031709004899 nucleotide binding pocket [chemical binding]; other site 1031709004900 K-X-D-G motif; other site 1031709004901 catalytic site [active] 1031709004902 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1031709004903 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1031709004904 Helix-hairpin-helix motif; Region: HHH; pfam00633 1031709004905 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1031709004906 Dimer interface [polypeptide binding]; other site 1031709004907 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 1031709004908 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 1031709004909 Zn binding site [ion binding]; other site 1031709004910 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1031709004911 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1031709004912 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1031709004913 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 1031709004914 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1031709004915 active site 1031709004916 catalytic site [active] 1031709004917 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1031709004918 active site 1031709004919 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1031709004920 active site 1031709004921 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1031709004922 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1031709004923 acyl-activating enzyme (AAE) consensus motif; other site 1031709004924 putative AMP binding site [chemical binding]; other site 1031709004925 putative active site [active] 1031709004926 putative CoA binding site [chemical binding]; other site 1031709004927 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1031709004928 MarR family; Region: MarR_2; pfam12802 1031709004929 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1031709004930 FAD binding domain; Region: FAD_binding_4; pfam01565 1031709004931 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1031709004932 Predicted transcriptional regulators [Transcription]; Region: COG1695 1031709004933 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1031709004934 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1031709004935 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1031709004936 Walker A/P-loop; other site 1031709004937 ATP binding site [chemical binding]; other site 1031709004938 Q-loop/lid; other site 1031709004939 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1031709004940 ABC transporter; Region: ABC_tran_2; pfam12848 1031709004941 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1031709004942 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1031709004943 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1031709004944 dimer interface [polypeptide binding]; other site 1031709004945 ssDNA binding site [nucleotide binding]; other site 1031709004946 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1031709004947 YfjP GTPase; Region: YfjP; cd11383 1031709004948 G1 box; other site 1031709004949 GTP/Mg2+ binding site [chemical binding]; other site 1031709004950 Switch I region; other site 1031709004951 G2 box; other site 1031709004952 Switch II region; other site 1031709004953 G3 box; other site 1031709004954 G4 box; other site 1031709004955 G5 box; other site 1031709004956 Dynamin family; Region: Dynamin_N; pfam00350 1031709004957 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1031709004958 G1 box; other site 1031709004959 GTP/Mg2+ binding site [chemical binding]; other site 1031709004960 G2 box; other site 1031709004961 Switch I region; other site 1031709004962 Protease prsW family; Region: PrsW-protease; pfam13367 1031709004963 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1031709004964 putative substrate translocation pore; other site 1031709004965 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1031709004966 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1031709004967 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1031709004968 catalytic site [active] 1031709004969 putative active site [active] 1031709004970 putative substrate binding site [chemical binding]; other site 1031709004971 dimer interface [polypeptide binding]; other site 1031709004972 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1031709004973 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1031709004974 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1031709004975 active site 1031709004976 ATP binding site [chemical binding]; other site 1031709004977 substrate binding site [chemical binding]; other site 1031709004978 activation loop (A-loop); other site 1031709004979 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1031709004980 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1031709004981 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 1031709004982 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1031709004983 active site 1031709004984 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1031709004985 generic binding surface I; other site 1031709004986 generic binding surface II; other site 1031709004987 DNA Polymerase Y-family; Region: PolY_like; cd03468 1031709004988 active site 1031709004989 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 1031709004990 DNA binding site [nucleotide binding] 1031709004991 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 1031709004992 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 1031709004993 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1031709004994 catalytic triad [active] 1031709004995 potential frameshift: common BLAST hit: gi|295131174|ref|YP_003581837.1| bacterial extracellular solute-binding protein 1031709004996 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1031709004997 dimer interface [polypeptide binding]; other site 1031709004998 conserved gate region; other site 1031709004999 putative PBP binding loops; other site 1031709005000 ABC-ATPase subunit interface; other site 1031709005001 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1031709005002 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1031709005003 dimer interface [polypeptide binding]; other site 1031709005004 conserved gate region; other site 1031709005005 putative PBP binding loops; other site 1031709005006 ABC-ATPase subunit interface; other site 1031709005007 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 1031709005008 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1031709005009 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1031709005010 catalytic triad [active] 1031709005011 CH-type (Chalaropsis-type) lysozymes represent one of four functionally-defined classes of peptidoglycan hydrolases (also referred to as endo-N-acetylmuramidases) that cleave bacterial cell wall peptidoglycans. CH-type lysozymes exhibit both lysozyme; Region: GH25_CH-type; cd06412 1031709005012 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1031709005013 active site 1031709005014 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 1031709005015 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1031709005016 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1031709005017 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1031709005018 putative active site [active] 1031709005019 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1031709005020 DNA polymerase IV; Provisional; Region: PRK03348 1031709005021 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1031709005022 active site 1031709005023 DNA binding site [nucleotide binding] 1031709005024 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1031709005025 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1031709005026 folate binding site [chemical binding]; other site 1031709005027 NADP+ binding site [chemical binding]; other site 1031709005028 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1031709005029 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1031709005030 dimerization interface [polypeptide binding]; other site 1031709005031 active site 1031709005032 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1031709005033 active site 1031709005034 dimerization interface [polypeptide binding]; other site 1031709005035 ribonuclease PH; Reviewed; Region: rph; PRK00173 1031709005036 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1031709005037 hexamer interface [polypeptide binding]; other site 1031709005038 active site 1031709005039 glutamate racemase; Provisional; Region: PRK00865 1031709005040 FeoA domain; Region: FeoA; pfam04023 1031709005041 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 1031709005042 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1031709005043 G1 box; other site 1031709005044 GTP/Mg2+ binding site [chemical binding]; other site 1031709005045 Switch I region; other site 1031709005046 G2 box; other site 1031709005047 G3 box; other site 1031709005048 Switch II region; other site 1031709005049 G4 box; other site 1031709005050 G5 box; other site 1031709005051 Nucleoside recognition; Region: Gate; pfam07670 1031709005052 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1031709005053 Nucleoside recognition; Region: Gate; pfam07670 1031709005054 NifU-like domain; Region: NifU; cl00484 1031709005055 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 1031709005056 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 1031709005057 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1031709005058 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1031709005059 active site 1031709005060 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1031709005061 IHF dimer interface [polypeptide binding]; other site 1031709005062 IHF - DNA interface [nucleotide binding]; other site 1031709005063 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 1031709005064 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 1031709005065 RDD family; Region: RDD; pfam06271 1031709005066 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 1031709005067 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1031709005068 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1031709005069 trimer interface [polypeptide binding]; other site 1031709005070 active site 1031709005071 dimer interface [polypeptide binding]; other site 1031709005072 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1031709005073 Cation efflux family; Region: Cation_efflux; pfam01545 1031709005074 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1031709005075 Trm112p-like protein; Region: Trm112p; cl01066 1031709005076 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 1031709005077 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 1031709005078 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit [DNA replication, recombination, and repair]; Region: GyrA; COG0188 1031709005079 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1031709005080 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1031709005081 active site 1031709005082 Transcription factor WhiB; Region: Whib; pfam02467 1031709005083 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1031709005084 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 1031709005085 Substrate binding site; other site 1031709005086 TIGR03089 family protein; Region: TIGR03089 1031709005087 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1031709005088 ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525 1031709005089 Ligand binding site; other site 1031709005090 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 1031709005091 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 1031709005092 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1031709005093 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1031709005094 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1031709005095 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 1031709005096 AIR carboxylase; Region: AIRC; pfam00731 1031709005097 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1031709005098 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1031709005099 NAD binding site [chemical binding]; other site 1031709005100 ATP-grasp domain; Region: ATP-grasp; pfam02222 1031709005101 Bacterial PH domain; Region: DUF304; cl01348 1031709005102 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 1031709005103 active site pocket [active] 1031709005104 oxyanion hole [active] 1031709005105 catalytic triad [active] 1031709005106 active site nucleophile [active] 1031709005107 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1031709005108 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1031709005109 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1031709005110 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1031709005111 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1031709005112 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 1031709005113 Maf-like protein; Region: Maf; pfam02545 1031709005114 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1031709005115 active site 1031709005116 dimer interface [polypeptide binding]; other site 1031709005117 short chain dehydrogenase; Provisional; Region: PRK08219 1031709005118 classical (c) SDRs; Region: SDR_c; cd05233 1031709005119 NAD(P) binding site [chemical binding]; other site 1031709005120 active site 1031709005121 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1031709005122 dimer interface [polypeptide binding]; other site 1031709005123 substrate binding site [chemical binding]; other site 1031709005124 ATP binding site [chemical binding]; other site 1031709005125 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1031709005126 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1031709005127 Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158 1031709005128 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 1031709005129 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 1031709005130 oligomer interface [polypeptide binding]; other site 1031709005131 metal binding site [ion binding]; metal-binding site 1031709005132 metal binding site [ion binding]; metal-binding site 1031709005133 putative Cl binding site [ion binding]; other site 1031709005134 aspartate ring; other site 1031709005135 basic sphincter; other site 1031709005136 hydrophobic gate; other site 1031709005137 periplasmic entrance; other site 1031709005138 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1031709005139 nudix motif; other site 1031709005140 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1031709005141 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1031709005142 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1031709005143 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1031709005144 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1031709005145 carboxyltransferase (CT) interaction site; other site 1031709005146 biotinylation site [posttranslational modification]; other site 1031709005147 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 1031709005148 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1031709005149 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1031709005150 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1031709005151 purine nucleoside phosphorylase; Provisional; Region: PRK08202 1031709005152 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 1031709005153 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1031709005154 active site 1031709005155 substrate binding site [chemical binding]; other site 1031709005156 metal binding site [ion binding]; metal-binding site 1031709005157 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1031709005158 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1031709005159 acyl-activating enzyme (AAE) consensus motif; other site 1031709005160 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1031709005161 AMP binding site [chemical binding]; other site 1031709005162 active site 1031709005163 acyl-activating enzyme (AAE) consensus motif; other site 1031709005164 CoA binding site [chemical binding]; other site 1031709005165 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1031709005166 putative transporter; Provisional; Region: PRK10504 1031709005167 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1031709005168 putative substrate translocation pore; other site 1031709005169 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 1031709005170 active site 1031709005171 catalytic site [active] 1031709005172 substrate binding site [chemical binding]; other site 1031709005173 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 1031709005174 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1031709005175 active site 1031709005176 HIGH motif; other site 1031709005177 KMSKS motif; other site 1031709005178 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1031709005179 tRNA binding surface [nucleotide binding]; other site 1031709005180 anticodon binding site; other site 1031709005181 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1031709005182 RNA/DNA hybrid binding site [nucleotide binding]; other site 1031709005183 active site 1031709005184 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1031709005185 active site 1031709005186 catalytic motif [active] 1031709005187 Zn binding site [ion binding]; other site 1031709005188 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1031709005189 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1031709005190 TM-ABC transporter signature motif; other site 1031709005191 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1031709005192 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1031709005193 TM-ABC transporter signature motif; other site 1031709005194 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1031709005195 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1031709005196 Walker A/P-loop; other site 1031709005197 ATP binding site [chemical binding]; other site 1031709005198 Q-loop/lid; other site 1031709005199 ABC transporter signature motif; other site 1031709005200 Walker B; other site 1031709005201 D-loop; other site 1031709005202 H-loop/switch region; other site 1031709005203 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1031709005204 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1031709005205 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 1031709005206 ligand binding site [chemical binding]; other site 1031709005207 Phosphotransferase enzyme family; Region: APH; pfam01636 1031709005208 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1031709005209 Domain of unknown function DUF21; Region: DUF21; pfam01595 1031709005210 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1031709005211 Transporter associated domain; Region: CorC_HlyC; smart01091 1031709005212 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 1031709005213 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 1031709005214 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1031709005215 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1031709005216 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 1031709005217 active site 1031709005218 substrate binding site [chemical binding]; other site 1031709005219 cosubstrate binding site; other site 1031709005220 catalytic site [active] 1031709005221 malate dehydrogenase; Provisional; Region: PRK05442 1031709005222 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 1031709005223 NAD(P) binding site [chemical binding]; other site 1031709005224 dimer interface [polypeptide binding]; other site 1031709005225 malate binding site [chemical binding]; other site 1031709005226 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 1031709005227 putative catalytic cysteine [active] 1031709005228 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 1031709005229 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 1031709005230 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1031709005231 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1031709005232 homodimer interface [polypeptide binding]; other site 1031709005233 NADP binding site [chemical binding]; other site 1031709005234 substrate binding site [chemical binding]; other site 1031709005235 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1031709005236 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1031709005237 catalytic residue [active] 1031709005238 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1031709005239 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1031709005240 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1031709005241 purine monophosphate binding site [chemical binding]; other site 1031709005242 dimer interface [polypeptide binding]; other site 1031709005243 putative catalytic residues [active] 1031709005244 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1031709005245 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1031709005246 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1031709005247 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1031709005248 active site 1031709005249 cosubstrate binding site; other site 1031709005250 substrate binding site [chemical binding]; other site 1031709005251 catalytic site [active] 1031709005252 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1031709005253 homopentamer interface [polypeptide binding]; other site 1031709005254 active site 1031709005255 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1031709005256 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1031709005257 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1031709005258 dimerization interface [polypeptide binding]; other site 1031709005259 active site 1031709005260 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1031709005261 Lumazine binding domain; Region: Lum_binding; pfam00677 1031709005262 Lumazine binding domain; Region: Lum_binding; pfam00677 1031709005263 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1031709005264 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1031709005265 catalytic motif [active] 1031709005266 Zn binding site [ion binding]; other site 1031709005267 RibD C-terminal domain; Region: RibD_C; cl17279 1031709005268 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1031709005269 CoA binding domain; Region: CoA_binding; smart00881 1031709005270 CoA-ligase; Region: Ligase_CoA; pfam00549 1031709005271 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1031709005272 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1031709005273 CoA-ligase; Region: Ligase_CoA; pfam00549 1031709005274 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1031709005275 Part of AAA domain; Region: AAA_19; pfam13245 1031709005276 Family description; Region: UvrD_C_2; pfam13538 1031709005277 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1031709005278 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1031709005279 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1031709005280 Walker A/P-loop; other site 1031709005281 ATP binding site [chemical binding]; other site 1031709005282 Q-loop/lid; other site 1031709005283 ABC transporter signature motif; other site 1031709005284 Walker B; other site 1031709005285 D-loop; other site 1031709005286 H-loop/switch region; other site 1031709005287 NIL domain; Region: NIL; pfam09383 1031709005288 ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism]; Region: AbcD; COG2011 1031709005289 ABC-ATPase subunit interface; other site 1031709005290 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1031709005291 PLD-like domain; Region: PLDc_2; pfam13091 1031709005292 putative active site [active] 1031709005293 catalytic site [active] 1031709005294 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1031709005295 PLD-like domain; Region: PLDc_2; pfam13091 1031709005296 putative active site [active] 1031709005297 catalytic site [active] 1031709005298 PspC domain; Region: PspC; pfam04024 1031709005299 GMP synthase; Reviewed; Region: guaA; PRK00074 1031709005300 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1031709005301 AMP/PPi binding site [chemical binding]; other site 1031709005302 candidate oxyanion hole; other site 1031709005303 catalytic triad [active] 1031709005304 potential glutamine specificity residues [chemical binding]; other site 1031709005305 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1031709005306 ATP Binding subdomain [chemical binding]; other site 1031709005307 Ligand Binding sites [chemical binding]; other site 1031709005308 Dimerization subdomain; other site 1031709005309 serine O-acetyltransferase; Region: cysE; TIGR01172 1031709005310 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1031709005311 trimer interface [polypeptide binding]; other site 1031709005312 active site 1031709005313 substrate binding site [chemical binding]; other site 1031709005314 CoA binding site [chemical binding]; other site 1031709005315 chorismate mutase; Provisional; Region: PRK09239 1031709005316 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 1031709005317 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1031709005318 phosphate binding site [ion binding]; other site 1031709005319 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1031709005320 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1031709005321 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1031709005322 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1031709005323 active site 1031709005324 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 1031709005325 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 1031709005326 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1031709005327 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1031709005328 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1031709005329 ring oligomerisation interface [polypeptide binding]; other site 1031709005330 ATP/Mg binding site [chemical binding]; other site 1031709005331 stacking interactions; other site 1031709005332 hinge regions; other site 1031709005333 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1031709005334 oligomerisation interface [polypeptide binding]; other site 1031709005335 mobile loop; other site 1031709005336 roof hairpin; other site 1031709005337 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1031709005338 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1031709005339 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1031709005340 Walker A/P-loop; other site 1031709005341 ATP binding site [chemical binding]; other site 1031709005342 Q-loop/lid; other site 1031709005343 ABC transporter signature motif; other site 1031709005344 Walker B; other site 1031709005345 D-loop; other site 1031709005346 H-loop/switch region; other site 1031709005347 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1031709005348 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1031709005349 ABC-ATPase subunit interface; other site 1031709005350 dimer interface [polypeptide binding]; other site 1031709005351 putative PBP binding regions; other site 1031709005352 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 1031709005353 Periplasmic binding protein TroA_f. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139 1031709005354 putative ligand binding residues [chemical binding]; other site 1031709005355 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 1031709005356 putative active site [active] 1031709005357 nucleotide binding site [chemical binding]; other site 1031709005358 nudix motif; other site 1031709005359 putative metal binding site [ion binding]; other site 1031709005360 UGMP family protein; Validated; Region: PRK09604 1031709005361 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 1031709005362 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1031709005363 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1031709005364 Coenzyme A binding pocket [chemical binding]; other site 1031709005365 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1031709005366 Glycoprotease family; Region: Peptidase_M22; pfam00814 1031709005367 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1031709005368 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1031709005369 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1031709005370 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1031709005371 ATP binding site [chemical binding]; other site 1031709005372 Mg++ binding site [ion binding]; other site 1031709005373 motif III; other site 1031709005374 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1031709005375 nucleotide binding region [chemical binding]; other site 1031709005376 ATP-binding site [chemical binding]; other site 1031709005377 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1031709005378 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1031709005379 Walker A/P-loop; other site 1031709005380 ATP binding site [chemical binding]; other site 1031709005381 Q-loop/lid; other site 1031709005382 ABC transporter signature motif; other site 1031709005383 Walker B; other site 1031709005384 D-loop; other site 1031709005385 H-loop/switch region; other site 1031709005386 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1031709005387 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1031709005388 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 1031709005389 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1031709005390 putative substrate binding site [chemical binding]; other site 1031709005391 putative ATP binding site [chemical binding]; other site 1031709005392 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1031709005393 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1031709005394 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1031709005395 glutaminase active site [active] 1031709005396 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1031709005397 dimer interface [polypeptide binding]; other site 1031709005398 active site 1031709005399 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1031709005400 dimer interface [polypeptide binding]; other site 1031709005401 active site 1031709005402 Lipase (class 2); Region: Lipase_2; pfam01674 1031709005403 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1031709005404 pantothenate kinase; Provisional; Region: PRK05439 1031709005405 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1031709005406 ATP-binding site [chemical binding]; other site 1031709005407 CoA-binding site [chemical binding]; other site 1031709005408 Mg2+-binding site [ion binding]; other site 1031709005409 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 1031709005410 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1031709005411 active site 1031709005412 substrate binding site [chemical binding]; other site 1031709005413 metal binding site [ion binding]; metal-binding site 1031709005414 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1031709005415 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1031709005416 23S rRNA interface [nucleotide binding]; other site 1031709005417 L3 interface [polypeptide binding]; other site 1031709005418 Endo-beta-N-acetylglucosaminidase D [Carbohydrate transport and metabolism]; Region: COG4724 1031709005419 Glycosyl hydrolase family 85; Region: Glyco_hydro_85; pfam03644 1031709005420 active site 1031709005421 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1031709005422 S-adenosylmethionine binding site [chemical binding]; other site 1031709005423 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1031709005424 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1031709005425 dimerization interface 3.5A [polypeptide binding]; other site 1031709005426 active site 1031709005427 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1031709005428 S-adenosylmethionine binding site [chemical binding]; other site 1031709005429 Cobalt transport protein; Region: CbiQ; cl00463 1031709005430 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1031709005431 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1031709005432 Walker A/P-loop; other site 1031709005433 ATP binding site [chemical binding]; other site 1031709005434 Q-loop/lid; other site 1031709005435 ABC transporter signature motif; other site 1031709005436 Walker B; other site 1031709005437 D-loop; other site 1031709005438 H-loop/switch region; other site 1031709005439 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1031709005440 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1031709005441 Walker A/P-loop; other site 1031709005442 ATP binding site [chemical binding]; other site 1031709005443 Q-loop/lid; other site 1031709005444 ABC transporter signature motif; other site 1031709005445 Walker B; other site 1031709005446 D-loop; other site 1031709005447 H-loop/switch region; other site 1031709005448 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 1031709005449 classical (c) SDRs; Region: SDR_c; cd05233 1031709005450 NAD(P) binding site [chemical binding]; other site 1031709005451 active site 1031709005452 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 1031709005453 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1031709005454 Walker A/P-loop; other site 1031709005455 ATP binding site [chemical binding]; other site 1031709005456 Q-loop/lid; other site 1031709005457 ABC transporter signature motif; other site 1031709005458 Walker B; other site 1031709005459 D-loop; other site 1031709005460 H-loop/switch region; other site 1031709005461 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1031709005462 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1031709005463 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1031709005464 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 1031709005465 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 1031709005466 Beta-galactosidase, domain 2; Region: BetaGal_dom2; smart01029 1031709005467 Beta-galactosidase, domain 2; Region: BetaGal_dom2; pfam10435 1031709005468 Beta-galactosidase jelly roll domain; Region: BetaGal_dom4_5; pfam13364 1031709005469 Beta-galactosidase jelly roll domain; Region: BetaGal_dom4_5; pfam13364 1031709005470 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 1031709005471 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 1031709005472 active site 1031709005473 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1031709005474 sugar binding site [chemical binding]; other site 1031709005475 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1031709005476 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1031709005477 putative substrate translocation pore; other site 1031709005478 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1031709005479 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1031709005480 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1031709005481 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1031709005482 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1031709005483 alphaNTD homodimer interface [polypeptide binding]; other site 1031709005484 alphaNTD - beta interaction site [polypeptide binding]; other site 1031709005485 alphaNTD - beta' interaction site [polypeptide binding]; other site 1031709005486 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1031709005487 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1031709005488 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1031709005489 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1031709005490 RNA binding surface [nucleotide binding]; other site 1031709005491 30S ribosomal protein S11; Validated; Region: PRK05309 1031709005492 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1031709005493 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1031709005494 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 1031709005495 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1031709005496 rRNA binding site [nucleotide binding]; other site 1031709005497 predicted 30S ribosome binding site; other site 1031709005498 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1031709005499 active site 1031709005500 adenylate kinase; Reviewed; Region: adk; PRK00279 1031709005501 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1031709005502 AMP-binding site [chemical binding]; other site 1031709005503 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1031709005504 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1031709005505 SecY translocase; Region: SecY; pfam00344 1031709005506 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1031709005507 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1031709005508 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 1031709005509 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 1031709005510 putative active site [active] 1031709005511 putative metal binding site [ion binding]; other site 1031709005512 catalytic site [active] 1031709005513 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1031709005514 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 1031709005515 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1031709005516 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1031709005517 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1031709005518 23S rRNA binding site [nucleotide binding]; other site 1031709005519 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1031709005520 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1031709005521 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1031709005522 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1031709005523 23S rRNA interface [nucleotide binding]; other site 1031709005524 5S rRNA interface [nucleotide binding]; other site 1031709005525 L27 interface [polypeptide binding]; other site 1031709005526 L5 interface [polypeptide binding]; other site 1031709005527 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1031709005528 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1031709005529 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1031709005530 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1031709005531 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 1031709005532 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1031709005533 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1031709005534 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1031709005535 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1031709005536 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1031709005537 RNA binding site [nucleotide binding]; other site 1031709005538 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1031709005539 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1031709005540 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1031709005541 23S rRNA interface [nucleotide binding]; other site 1031709005542 putative translocon interaction site; other site 1031709005543 signal recognition particle (SRP54) interaction site; other site 1031709005544 L23 interface [polypeptide binding]; other site 1031709005545 trigger factor interaction site; other site 1031709005546 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1031709005547 23S rRNA interface [nucleotide binding]; other site 1031709005548 5S rRNA interface [nucleotide binding]; other site 1031709005549 putative antibiotic binding site [chemical binding]; other site 1031709005550 L25 interface [polypeptide binding]; other site 1031709005551 L27 interface [polypeptide binding]; other site 1031709005552 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1031709005553 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1031709005554 G-X-X-G motif; other site 1031709005555 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1031709005556 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1031709005557 putative translocon binding site; other site 1031709005558 protein-rRNA interface [nucleotide binding]; other site 1031709005559 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1031709005560 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1031709005561 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1031709005562 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1031709005563 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1031709005564 50S ribosomal protein L4; Provisional; Region: rplD; PRK14547 1031709005565 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1031709005566 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1031709005567 6-carboxyhexanoate--CoA ligase; Region: BioW; pfam03744 1031709005568 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 1031709005569 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1031709005570 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1031709005571 catalytic residue [active] 1031709005572 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1031709005573 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1031709005574 HIGH motif; other site 1031709005575 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1031709005576 active site 1031709005577 KMSKS motif; other site 1031709005578 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 1031709005579 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1031709005580 active site 1031709005581 HIGH motif; other site 1031709005582 nucleotide binding site [chemical binding]; other site 1031709005583 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1031709005584 active site 1031709005585 KMSKS motif; other site 1031709005586 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 1031709005587 2',3'-cyclic-nucleotide 2'-phosphodiesterase; Region: CycNucDiestase; TIGR01390 1031709005588 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 1031709005589 active site 1031709005590 metal binding site [ion binding]; metal-binding site 1031709005591 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1031709005592 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 1031709005593 elongation factor Tu; Reviewed; Region: PRK00049 1031709005594 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1031709005595 G1 box; other site 1031709005596 GEF interaction site [polypeptide binding]; other site 1031709005597 GTP/Mg2+ binding site [chemical binding]; other site 1031709005598 Switch I region; other site 1031709005599 G2 box; other site 1031709005600 G3 box; other site 1031709005601 Switch II region; other site 1031709005602 G4 box; other site 1031709005603 G5 box; other site 1031709005604 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1031709005605 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1031709005606 Antibiotic Binding Site [chemical binding]; other site 1031709005607 elongation factor G; Reviewed; Region: PRK00007 1031709005608 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1031709005609 G1 box; other site 1031709005610 putative GEF interaction site [polypeptide binding]; other site 1031709005611 GTP/Mg2+ binding site [chemical binding]; other site 1031709005612 Switch I region; other site 1031709005613 G2 box; other site 1031709005614 G3 box; other site 1031709005615 Switch II region; other site 1031709005616 G4 box; other site 1031709005617 G5 box; other site 1031709005618 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1031709005619 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1031709005620 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1031709005621 30S ribosomal protein S7; Validated; Region: PRK05302 1031709005622 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1031709005623 S17 interaction site [polypeptide binding]; other site 1031709005624 S8 interaction site; other site 1031709005625 16S rRNA interaction site [nucleotide binding]; other site 1031709005626 streptomycin interaction site [chemical binding]; other site 1031709005627 23S rRNA interaction site [nucleotide binding]; other site 1031709005628 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1031709005629 Filamin/ABP280 repeat; Region: Filamin; pfam00630 1031709005630 potential frameshift: common BLAST hit: gi|365974702|ref|YP_004956261.1| actinobacterial surface-anchored protein domain protein 1031709005631 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 1031709005632 putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773 1031709005633 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 1031709005634 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1031709005635 DNA-directed RNA polymerase, beta' subunit, predominant form; Region: rpoC_TIGR; TIGR02386 1031709005636 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1031709005637 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1031709005638 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1031709005639 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1031709005640 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 1031709005641 G-loop; other site 1031709005642 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1031709005643 DNA binding site [nucleotide binding] 1031709005644 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1031709005645 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1031709005646 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1031709005647 RPB12 interaction site [polypeptide binding]; other site 1031709005648 RPB1 interaction site [polypeptide binding]; other site 1031709005649 RPB10 interaction site [polypeptide binding]; other site 1031709005650 RPB11 interaction site [polypeptide binding]; other site 1031709005651 RPB3 interaction site [polypeptide binding]; other site 1031709005652 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1031709005653 core dimer interface [polypeptide binding]; other site 1031709005654 peripheral dimer interface [polypeptide binding]; other site 1031709005655 L10 interface [polypeptide binding]; other site 1031709005656 L11 interface [polypeptide binding]; other site 1031709005657 putative EF-Tu interaction site [polypeptide binding]; other site 1031709005658 putative EF-G interaction site [polypeptide binding]; other site 1031709005659 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1031709005660 23S rRNA interface [nucleotide binding]; other site 1031709005661 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1031709005662 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1031709005663 mRNA/rRNA interface [nucleotide binding]; other site 1031709005664 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1031709005665 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1031709005666 23S rRNA interface [nucleotide binding]; other site 1031709005667 putative thiostrepton binding site; other site 1031709005668 L7/L12 interface [polypeptide binding]; other site 1031709005669 L25 interface [polypeptide binding]; other site 1031709005670 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1031709005671 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1031709005672 putative homodimer interface [polypeptide binding]; other site 1031709005673 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1031709005674 heterodimer interface [polypeptide binding]; other site 1031709005675 homodimer interface [polypeptide binding]; other site 1031709005676 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 1031709005677 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 1031709005678 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1031709005679 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1031709005680 homodimer interface [polypeptide binding]; other site 1031709005681 catalytic residue [active] 1031709005682 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 1031709005683 FAD binding domain; Region: FAD_binding_4; pfam01565 1031709005684 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1031709005685 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 1031709005686 active site 1031709005687 catalytic site [active] 1031709005688 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1031709005689 active site 1031709005690 catalytic site [active] 1031709005691 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 1031709005692 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 1031709005693 putative active site [active] 1031709005694 putative catalytic site [active] 1031709005695 putative DNA binding site [nucleotide binding]; other site 1031709005696 putative phosphate binding site [ion binding]; other site 1031709005697 metal binding site A [ion binding]; metal-binding site 1031709005698 putative AP binding site [nucleotide binding]; other site 1031709005699 putative metal binding site B [ion binding]; other site 1031709005700 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1031709005701 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 1031709005702 substrate binding site [chemical binding]; other site 1031709005703 oxyanion hole (OAH) forming residues; other site 1031709005704 trimer interface [polypeptide binding]; other site 1031709005705 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 1031709005706 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 1031709005707 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 1031709005708 4Fe-4S binding domain; Region: Fer4; cl02805 1031709005709 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329 1031709005710 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194 1031709005711 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 1031709005712 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1031709005713 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1031709005714 dimer interface [polypeptide binding]; other site 1031709005715 PYR/PP interface [polypeptide binding]; other site 1031709005716 TPP binding site [chemical binding]; other site 1031709005717 substrate binding site [chemical binding]; other site 1031709005718 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 1031709005719 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 1031709005720 TPP-binding site [chemical binding]; other site 1031709005721 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 1031709005722 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 1031709005723 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 1031709005724 active site 1031709005725 catalytic triad [active] 1031709005726 oxyanion hole [active] 1031709005727 Thrombospondin type 3 repeat; Region: TSP_3; pfam02412 1031709005728 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 1031709005729 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 1031709005730 active site 1031709005731 Zn binding site [ion binding]; other site 1031709005732 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136 1031709005733 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1031709005734 Walker A/P-loop; other site 1031709005735 ATP binding site [chemical binding]; other site 1031709005736 Q-loop/lid; other site 1031709005737 ABC transporter signature motif; other site 1031709005738 Walker B; other site 1031709005739 D-loop; other site 1031709005740 H-loop/switch region; other site 1031709005741 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1031709005742 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1031709005743 Walker A/P-loop; other site 1031709005744 ATP binding site [chemical binding]; other site 1031709005745 Q-loop/lid; other site 1031709005746 ABC transporter signature motif; other site 1031709005747 Walker B; other site 1031709005748 D-loop; other site 1031709005749 H-loop/switch region; other site 1031709005750 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1031709005751 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 1031709005752 active site 1031709005753 SAM binding site [chemical binding]; other site 1031709005754 homodimer interface [polypeptide binding]; other site 1031709005755 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1031709005756 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1031709005757 substrate binding pocket [chemical binding]; other site 1031709005758 chain length determination region; other site 1031709005759 substrate-Mg2+ binding site; other site 1031709005760 catalytic residues [active] 1031709005761 aspartate-rich region 1; other site 1031709005762 active site lid residues [active] 1031709005763 aspartate-rich region 2; other site 1031709005764 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1031709005765 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1031709005766 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1031709005767 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1031709005768 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1031709005769 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1031709005770 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1031709005771 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1031709005772 NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839 1031709005773 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 1031709005774 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 1031709005775 4Fe-4S binding domain; Region: Fer4; pfam00037 1031709005776 4Fe-4S binding domain; Region: Fer4; pfam00037 1031709005777 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1031709005778 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1031709005779 NADH dehydrogenase subunit G; Validated; Region: PRK07860 1031709005780 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1031709005781 catalytic loop [active] 1031709005782 iron binding site [ion binding]; other site 1031709005783 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1031709005784 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 1031709005785 [4Fe-4S] binding site [ion binding]; other site 1031709005786 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 1031709005787 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 1031709005788 SLBB domain; Region: SLBB; pfam10531 1031709005789 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 1031709005790 NADH dehydrogenase subunit E; Validated; Region: PRK07539 1031709005791 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1031709005792 putative dimer interface [polypeptide binding]; other site 1031709005793 [2Fe-2S] cluster binding site [ion binding]; other site 1031709005794 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 1031709005795 NADH dehydrogenase subunit D; Validated; Region: PRK06075 1031709005796 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 1031709005797 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 1031709005798 NADH dehydrogenase subunit B; Validated; Region: PRK06411 1031709005799 NADH dehydrogenase subunit A; Validated; Region: PRK07928 1031709005800 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 1031709005801 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1031709005802 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539 1031709005803 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1031709005804 Walker A/P-loop; other site 1031709005805 ATP binding site [chemical binding]; other site 1031709005806 Q-loop/lid; other site 1031709005807 ABC transporter signature motif; other site 1031709005808 Walker B; other site 1031709005809 D-loop; other site 1031709005810 H-loop/switch region; other site 1031709005811 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1031709005812 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1031709005813 RNase_H superfamily; Region: RNase_H_2; pfam13482 1031709005814 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 1031709005815 UbiA prenyltransferase family; Region: UbiA; pfam01040 1031709005816 H+ Antiporter protein; Region: 2A0121; TIGR00900 1031709005817 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1031709005818 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1031709005819 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 1031709005820 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 1031709005821 DAK2 domain; Region: Dak2; cl03685 1031709005822 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 1031709005823 active pocket/dimerization site; other site 1031709005824 active site 1031709005825 phosphorylation site [posttranslational modification] 1031709005826 Deoxycytidylate deaminase [Nucleotide transport and metabolism]; Region: ComEB; COG2131 1031709005827 active site 1031709005828 Zn binding site [ion binding]; other site 1031709005829 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1031709005830 Cation efflux family; Region: Cation_efflux; cl00316 1031709005831 A subgroup of L-lactate dehydrogenases; Region: LDH_3; cd05290 1031709005832 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 1031709005833 NAD binding site [chemical binding]; other site 1031709005834 dimer interface [polypeptide binding]; other site 1031709005835 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1031709005836 substrate binding site [chemical binding]; other site 1031709005837 Patatin-like phospholipase; Region: Patatin; pfam01734 1031709005838 active site 1031709005839 nucleophile elbow; other site 1031709005840 Patatin-like phospholipase; Region: Patatin; pfam01734 1031709005841 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1031709005842 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1031709005843 active site 1031709005844 motif I; other site 1031709005845 motif II; other site 1031709005846 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1031709005847 Right handed beta helix region; Region: Beta_helix; pfam13229 1031709005848 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 1031709005849 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1031709005850 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1031709005851 Domain of unknown function (DUF4091); Region: DUF4091; pfam13320 1031709005852 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1031709005853 dimer interface [polypeptide binding]; other site 1031709005854 conserved gate region; other site 1031709005855 putative PBP binding loops; other site 1031709005856 ABC-ATPase subunit interface; other site 1031709005857 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1031709005858 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1031709005859 dimer interface [polypeptide binding]; other site 1031709005860 conserved gate region; other site 1031709005861 putative PBP binding loops; other site 1031709005862 ABC-ATPase subunit interface; other site 1031709005863 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1031709005864 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1031709005865 Bacterial SH3 domain; Region: SH3_3; pfam08239 1031709005866 Bacterial SH3 domain; Region: SH3_3; cl17532 1031709005867 Bacterial SH3 domain; Region: SH3_3; cl17532 1031709005868 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1031709005869 NlpC/P60 family; Region: NLPC_P60; cl17555 1031709005870 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1031709005871 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1031709005872 dimer interface [polypeptide binding]; other site 1031709005873 conserved gate region; other site 1031709005874 putative PBP binding loops; other site 1031709005875 ABC-ATPase subunit interface; other site 1031709005876 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1031709005877 dimer interface [polypeptide binding]; other site 1031709005878 conserved gate region; other site 1031709005879 putative PBP binding loops; other site 1031709005880 ABC-ATPase subunit interface; other site 1031709005881 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1031709005882 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1031709005883 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1031709005884 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 1031709005885 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1031709005886 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1031709005887 dimerization interface [polypeptide binding]; other site 1031709005888 putative ATP binding site [chemical binding]; other site 1031709005889 amidophosphoribosyltransferase; Provisional; Region: PRK07847 1031709005890 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1031709005891 active site 1031709005892 tetramer interface [polypeptide binding]; other site 1031709005893 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1031709005894 active site 1031709005895 hypothetical protein; Provisional; Region: PRK07907 1031709005896 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 1031709005897 active site 1031709005898 metal binding site [ion binding]; metal-binding site 1031709005899 dimer interface [polypeptide binding]; other site 1031709005900 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1031709005901 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1031709005902 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 1031709005903 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1031709005904 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1031709005905 glutamine binding [chemical binding]; other site 1031709005906 catalytic triad [active] 1031709005907 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1031709005908 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 1031709005909 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1031709005910 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1031709005911 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1031709005912 dimerization interface [polypeptide binding]; other site 1031709005913 ATP binding site [chemical binding]; other site 1031709005914 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1031709005915 dimerization interface [polypeptide binding]; other site 1031709005916 ATP binding site [chemical binding]; other site 1031709005917 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1031709005918 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1031709005919 putative substrate translocation pore; other site 1031709005920 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 1031709005921 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 1031709005922 Zn binding site [ion binding]; other site 1031709005923 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 1031709005924 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1031709005925 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1031709005926 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1031709005927 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 1031709005928 active site 1031709005929 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1031709005930 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1031709005931 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1031709005932 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1031709005933 putative active site [active] 1031709005934 catalytic triad [active] 1031709005935 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 1031709005936 ATP binding site [chemical binding]; other site 1031709005937 active site 1031709005938 substrate binding site [chemical binding]; other site 1031709005939 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 1031709005940 peroxiredoxin; Region: AhpC; TIGR03137 1031709005941 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1031709005942 dimer interface [polypeptide binding]; other site 1031709005943 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1031709005944 catalytic triad [active] 1031709005945 peroxidatic and resolving cysteines [active] 1031709005946 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 1031709005947 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1031709005948 catalytic residue [active] 1031709005949 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 1031709005950 catalytic residues [active] 1031709005951 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1031709005952 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1031709005953 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1031709005954 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1031709005955 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 1031709005956 dimerization interface [polypeptide binding]; other site 1031709005957 adenylosuccinate lyase; Region: purB; TIGR00928 1031709005958 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 1031709005959 tetramer interface [polypeptide binding]; other site 1031709005960 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1031709005961 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1031709005962 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1031709005963 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1031709005964 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1031709005965 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1031709005966 GDP-binding site [chemical binding]; other site 1031709005967 ACT binding site; other site 1031709005968 IMP binding site; other site 1031709005969 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1031709005970 Coenzyme A binding pocket [chemical binding]; other site 1031709005971 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1031709005972 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1031709005973 DNA-binding site [nucleotide binding]; DNA binding site 1031709005974 FCD domain; Region: FCD; pfam07729 1031709005975 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 1031709005976 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 1031709005977 putative active site cavity [active] 1031709005978 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1031709005979 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1031709005980 inhibitor site; inhibition site 1031709005981 active site 1031709005982 dimer interface [polypeptide binding]; other site 1031709005983 catalytic residue [active] 1031709005984 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1031709005985 putative sialic acid transporter; Provisional; Region: PRK03893 1031709005986 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1031709005987 putative substrate translocation pore; other site 1031709005988 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1031709005989 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 1031709005990 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1031709005991 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 1031709005992 G1 box; other site 1031709005993 putative GEF interaction site [polypeptide binding]; other site 1031709005994 GTP/Mg2+ binding site [chemical binding]; other site 1031709005995 Switch I region; other site 1031709005996 G2 box; other site 1031709005997 G3 box; other site 1031709005998 Switch II region; other site 1031709005999 G4 box; other site 1031709006000 G5 box; other site 1031709006001 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1031709006002 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1031709006003 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1031709006004 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1031709006005 carboxyltransferase (CT) interaction site; other site 1031709006006 biotinylation site [posttranslational modification]; other site 1031709006007 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 1031709006008 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1031709006009 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1031709006010 oxaloacetate decarboxylase; Provisional; Region: PRK12330 1031709006011 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1031709006012 active site 1031709006013 catalytic residues [active] 1031709006014 metal binding site [ion binding]; metal-binding site 1031709006015 homodimer binding site [polypeptide binding]; other site 1031709006016 PAS domain; Region: PAS_9; pfam13426 1031709006017 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1031709006018 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 1031709006019 active site 1031709006020 intersubunit interface [polypeptide binding]; other site 1031709006021 zinc binding site [ion binding]; other site 1031709006022 Na+ binding site [ion binding]; other site 1031709006023 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1031709006024 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1031709006025 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1031709006026 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1031709006027 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1031709006028 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1031709006029 SEC-C motif; Region: SEC-C; pfam02810 1031709006030 hypothetical protein; Provisional; Region: PRK04233 1031709006031 benzoate transport; Region: 2A0115; TIGR00895 1031709006032 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1031709006033 putative substrate translocation pore; other site 1031709006034 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1031709006035 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1031709006036 Clp amino terminal domain; Region: Clp_N; pfam02861 1031709006037 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1031709006038 Walker A motif; other site 1031709006039 ATP binding site [chemical binding]; other site 1031709006040 Walker B motif; other site 1031709006041 arginine finger; other site 1031709006042 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1031709006043 Walker A motif; other site 1031709006044 ATP binding site [chemical binding]; other site 1031709006045 Walker B motif; other site 1031709006046 arginine finger; other site 1031709006047 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1031709006048 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 1031709006049 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 1031709006050 Eukaryotic phosphomannomutase; Region: PMM; cl17107 1031709006051 fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377 1031709006052 catalytic residue [active] 1031709006053 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 1031709006054 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 1031709006055 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1031709006056 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1031709006057 Histidine kinase; Region: HisKA_3; pfam07730 1031709006058 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1031709006059 ATP binding site [chemical binding]; other site 1031709006060 Mg2+ binding site [ion binding]; other site 1031709006061 G-X-G motif; other site 1031709006062 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1031709006063 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1031709006064 active site 1031709006065 phosphorylation site [posttranslational modification] 1031709006066 intermolecular recognition site; other site 1031709006067 dimerization interface [polypeptide binding]; other site 1031709006068 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1031709006069 DNA binding residues [nucleotide binding] 1031709006070 dimerization interface [polypeptide binding]; other site 1031709006071 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1031709006072 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1031709006073 Walker A/P-loop; other site 1031709006074 ATP binding site [chemical binding]; other site 1031709006075 Q-loop/lid; other site 1031709006076 ABC transporter signature motif; other site 1031709006077 Walker B; other site 1031709006078 D-loop; other site 1031709006079 H-loop/switch region; other site 1031709006080 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1031709006081 FtsX-like permease family; Region: FtsX; pfam02687 1031709006082 FtsX-like permease family; Region: FtsX; pfam02687 1031709006083 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 1031709006084 nudix motif; other site 1031709006085 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1031709006086 Predicted permease [General function prediction only]; Region: COG2985 1031709006087 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 1031709006088 TrkA-C domain; Region: TrkA_C; pfam02080 1031709006089 TrkA-C domain; Region: TrkA_C; pfam02080 1031709006090 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 1031709006091 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1031709006092 6-hydroxycyclohex-1-ene-1-carboxyl-CoA dehydrogenase, N-benzyl-3-pyrrolidinol dehydrogenase, and other MDR family members; Region: hydroxyacyl_CoA_DH; cd08254 1031709006093 putative NAD(P) binding site [chemical binding]; other site 1031709006094 catalytic Zn binding site [ion binding]; other site 1031709006095 structural Zn binding site [ion binding]; other site 1031709006096 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1031709006097 active site 1031709006098 catalytic triad [active] 1031709006099 oxyanion hole [active] 1031709006100 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 1031709006101 DNA binding residues [nucleotide binding] 1031709006102 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1031709006103 putative dimer interface [polypeptide binding]; other site 1031709006104 chaperone protein DnaJ; Provisional; Region: PRK14295 1031709006105 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1031709006106 HSP70 interaction site [polypeptide binding]; other site 1031709006107 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1031709006108 Zn binding sites [ion binding]; other site 1031709006109 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1031709006110 dimer interface [polypeptide binding]; other site 1031709006111 GrpE; Region: GrpE; pfam01025 1031709006112 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1031709006113 dimer interface [polypeptide binding]; other site 1031709006114 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1031709006115 NAD-specific glutamate dehydrogenase; Region: NAD-GH; pfam10712 1031709006116 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1031709006117 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1031709006118 nucleotide binding site [chemical binding]; other site 1031709006119 NEF interaction site [polypeptide binding]; other site 1031709006120 SBD interface [polypeptide binding]; other site 1031709006121 Phosphate transporter family; Region: PHO4; pfam01384 1031709006122 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1031709006123 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1031709006124 active site 1031709006125 phosphorylation site [posttranslational modification] 1031709006126 intermolecular recognition site; other site 1031709006127 dimerization interface [polypeptide binding]; other site 1031709006128 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1031709006129 DNA binding site [nucleotide binding] 1031709006130 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1031709006131 intersubunit interface [polypeptide binding]; other site 1031709006132 active site 1031709006133 catalytic residue [active] 1031709006134 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1; cd01653 1031709006135 conserved cys residue [active] 1031709006136 FHA domain; Region: FHA; pfam00498 1031709006137 phosphopeptide binding site; other site 1031709006138 pyruvate phosphate dikinase; Provisional; Region: PRK09279 1031709006139 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1031709006140 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1031709006141 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1031709006142 PEP synthetase regulatory protein; Provisional; Region: PRK05339 1031709006143 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 1031709006144 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1031709006145 S-adenosylmethionine binding site [chemical binding]; other site 1031709006146 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1031709006147 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1031709006148 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 1031709006149 active site 1031709006150 catalytic residues [active] 1031709006151 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 1031709006152 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 1031709006153 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1031709006154 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1031709006155 Amidase; Region: Amidase; cl11426 1031709006156 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1031709006157 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1031709006158 DNA binding site [nucleotide binding] 1031709006159 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 1031709006160 ligand binding site [chemical binding]; other site 1031709006161 dimerization interface (open form) [polypeptide binding]; other site 1031709006162 dimerization interface (closed form) [polypeptide binding]; other site 1031709006163 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cd00413 1031709006164 active site 1031709006165 catalytic residues [active] 1031709006166 Melibiase; Region: Melibiase; pfam02065 1031709006167 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1031709006168 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1031709006169 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1031709006170 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1031709006171 dimer interface [polypeptide binding]; other site 1031709006172 conserved gate region; other site 1031709006173 putative PBP binding loops; other site 1031709006174 ABC-ATPase subunit interface; other site 1031709006175 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1031709006176 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1031709006177 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1031709006178 dimer interface [polypeptide binding]; other site 1031709006179 ABC-ATPase subunit interface; other site 1031709006180 putative PBP binding loops; other site 1031709006181 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 1031709006182 Uncharacterized conserved protein [Function unknown]; Region: COG5476 1031709006183 MlrC C-terminus; Region: MlrC_C; pfam07171 1031709006184 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1031709006185 MarR family; Region: MarR_2; pfam12802 1031709006186 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1031709006187 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1031709006188 nucleotide binding site [chemical binding]; other site 1031709006189 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1031709006190 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 1031709006191 peptide binding site [polypeptide binding]; other site 1031709006192 dimer interface [polypeptide binding]; other site 1031709006193 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1031709006194 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1031709006195 dimer interface [polypeptide binding]; other site 1031709006196 conserved gate region; other site 1031709006197 putative PBP binding loops; other site 1031709006198 ABC-ATPase subunit interface; other site 1031709006199 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1031709006200 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1031709006201 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1031709006202 dimer interface [polypeptide binding]; other site 1031709006203 conserved gate region; other site 1031709006204 putative PBP binding loops; other site 1031709006205 ABC-ATPase subunit interface; other site 1031709006206 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 1031709006207 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1031709006208 Walker A/P-loop; other site 1031709006209 ATP binding site [chemical binding]; other site 1031709006210 Q-loop/lid; other site 1031709006211 ABC transporter signature motif; other site 1031709006212 Walker B; other site 1031709006213 D-loop; other site 1031709006214 H-loop/switch region; other site 1031709006215 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1031709006216 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1031709006217 Walker A/P-loop; other site 1031709006218 ATP binding site [chemical binding]; other site 1031709006219 Q-loop/lid; other site 1031709006220 ABC transporter signature motif; other site 1031709006221 Walker B; other site 1031709006222 D-loop; other site 1031709006223 H-loop/switch region; other site 1031709006224 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1031709006225 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1031709006226 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1031709006227 nucleotide binding site [chemical binding]; other site 1031709006228 Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812 1031709006229 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 1031709006230 potential protein location (hypothetical protein TIB1ST10_10520 [Propionibacterium acnes 6609]) that overlaps RNA (tRNA-G) 1031709006231 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 1031709006232 putative active site [active] 1031709006233 homotetrameric interface [polypeptide binding]; other site 1031709006234 metal binding site [ion binding]; metal-binding site 1031709006235 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 1031709006236 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 1031709006237 active site 1031709006238 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1031709006239 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1031709006240 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1031709006241 AAA domain; Region: AAA_21; pfam13304 1031709006242 Walker A/P-loop; other site 1031709006243 ATP binding site [chemical binding]; other site 1031709006244 ABC transporter; Region: ABC_tran; pfam00005 1031709006245 Q-loop/lid; other site 1031709006246 ABC transporter signature motif; other site 1031709006247 Walker B; other site 1031709006248 D-loop; other site 1031709006249 H-loop/switch region; other site 1031709006250 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1031709006251 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1031709006252 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1031709006253 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1031709006254 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1031709006255 Walker A/P-loop; other site 1031709006256 ATP binding site [chemical binding]; other site 1031709006257 Q-loop/lid; other site 1031709006258 ABC transporter signature motif; other site 1031709006259 Walker B; other site 1031709006260 D-loop; other site 1031709006261 H-loop/switch region; other site 1031709006262 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; pfam09605 1031709006263 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1031709006264 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1031709006265 Walker A/P-loop; other site 1031709006266 ATP binding site [chemical binding]; other site 1031709006267 Q-loop/lid; other site 1031709006268 ABC transporter signature motif; other site 1031709006269 Walker B; other site 1031709006270 D-loop; other site 1031709006271 H-loop/switch region; other site 1031709006272 Second domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain2; cd03226 1031709006273 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 1031709006274 Walker A/P-loop; other site 1031709006275 ATP binding site [chemical binding]; other site 1031709006276 Q-loop/lid; other site 1031709006277 ABC transporter signature motif; other site 1031709006278 Walker B; other site 1031709006279 D-loop; other site 1031709006280 H-loop/switch region; other site 1031709006281 EcsC protein family; Region: EcsC; pfam12787 1031709006282 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1031709006283 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 1031709006284 Walker A/P-loop; other site 1031709006285 ATP binding site [chemical binding]; other site 1031709006286 Q-loop/lid; other site 1031709006287 ABC transporter signature motif; other site 1031709006288 Walker B; other site 1031709006289 D-loop; other site 1031709006290 H-loop/switch region; other site 1031709006291 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1031709006292 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1031709006293 E3 interaction surface; other site 1031709006294 lipoyl attachment site [posttranslational modification]; other site 1031709006295 e3 binding domain; Region: E3_binding; pfam02817 1031709006296 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1031709006297 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1031709006298 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1031709006299 alpha subunit interface [polypeptide binding]; other site 1031709006300 TPP binding site [chemical binding]; other site 1031709006301 heterodimer interface [polypeptide binding]; other site 1031709006302 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1031709006303 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1031709006304 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1031709006305 TPP-binding site [chemical binding]; other site 1031709006306 tetramer interface [polypeptide binding]; other site 1031709006307 heterodimer interface [polypeptide binding]; other site 1031709006308 phosphorylation loop region [posttranslational modification] 1031709006309 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1031709006310 radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053 1031709006311 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1031709006312 FeS/SAM binding site; other site 1031709006313 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1031709006314 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1031709006315 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 1031709006316 putative active site [active] 1031709006317 putative metal binding site [ion binding]; other site 1031709006318 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1031709006319 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1031709006320 H-loop/switch region; other site 1031709006321 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1031709006322 WYL domain; Region: WYL; pfam13280 1031709006323 WYL domain; Region: WYL; pfam13280 1031709006324 HTH domain; Region: HTH_11; pfam08279 1031709006325 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1031709006326 active site 1031709006327 metal binding site [ion binding]; metal-binding site 1031709006328 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1031709006329 Integrase core domain; Region: rve_3; pfam13683 1031709006330 Lipase (class 2); Region: Lipase_2; pfam01674 1031709006331 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 1031709006332 CAMP factor (Cfa); Region: CAMP_factor; pfam07373 1031709006333 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1031709006334 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1031709006335 active site 1031709006336 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 1031709006337 proposed catalytic triad [active] 1031709006338 active site nucleophile [active] 1031709006339 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1031709006340 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1031709006341 active site 1031709006342 phosphorylation site [posttranslational modification] 1031709006343 intermolecular recognition site; other site 1031709006344 dimerization interface [polypeptide binding]; other site 1031709006345 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1031709006346 DNA binding site [nucleotide binding] 1031709006347 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1031709006348 HAMP domain; Region: HAMP; pfam00672 1031709006349 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1031709006350 dimer interface [polypeptide binding]; other site 1031709006351 phosphorylation site [posttranslational modification] 1031709006352 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1031709006353 ATP binding site [chemical binding]; other site 1031709006354 Mg2+ binding site [ion binding]; other site 1031709006355 G-X-G motif; other site 1031709006356 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 1031709006357 catalytic nucleophile [active] 1031709006358 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 1031709006359 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 1031709006360 active site 1031709006361 metal binding site [ion binding]; metal-binding site 1031709006362 nudix motif; other site 1031709006363 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1031709006364 YCII-related domain; Region: YCII; cl00999 1031709006365 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1031709006366 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 1031709006367 active site 1031709006368 FMN binding site [chemical binding]; other site 1031709006369 substrate binding site [chemical binding]; other site 1031709006370 homotetramer interface [polypeptide binding]; other site 1031709006371 catalytic residue [active] 1031709006372 metabolite-proton symporter; Region: 2A0106; TIGR00883 1031709006373 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1031709006374 putative substrate translocation pore; other site 1031709006375 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK06539 1031709006376 ATP cone domain; Region: ATP-cone; pfam03477 1031709006377 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1031709006378 active site 1031709006379 dimer interface [polypeptide binding]; other site 1031709006380 catalytic residues [active] 1031709006381 effector binding site; other site 1031709006382 R2 peptide binding site; other site 1031709006383 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1031709006384 dimer interface [polypeptide binding]; other site 1031709006385 putative radical transfer pathway; other site 1031709006386 diiron center [ion binding]; other site 1031709006387 tyrosyl radical; other site 1031709006388 Bacterial PH domain; Region: DUF304; pfam03703 1031709006389 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1031709006390 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1031709006391 nucleotide binding site [chemical binding]; other site 1031709006392 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 1031709006393 ornithine carbamoyltransferase; Validated; Region: PRK02102 1031709006394 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 1031709006395 arginine-tRNA ligase; Region: PLN02286 1031709006396 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1031709006397 active site 1031709006398 HIGH motif; other site 1031709006399 KMSK motif region; other site 1031709006400 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1031709006401 tRNA binding surface [nucleotide binding]; other site 1031709006402 anticodon binding site; other site 1031709006403 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1031709006404 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1031709006405 active site 1031709006406 catalytic tetrad [active] 1031709006407 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1031709006408 putative active site [active] 1031709006409 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1031709006410 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1031709006411 active site 1031709006412 dimer interface [polypeptide binding]; other site 1031709006413 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1031709006414 dimer interface [polypeptide binding]; other site 1031709006415 active site 1031709006416 Predicted solute binding protein [General function prediction only]; Region: COG3889 1031709006417 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1031709006418 active site 1031709006419 intersubunit interface [polypeptide binding]; other site 1031709006420 catalytic residue [active] 1031709006421 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1031709006422 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1031709006423 dimerization interface [polypeptide binding]; other site 1031709006424 DPS ferroxidase diiron center [ion binding]; other site 1031709006425 ion pore; other site 1031709006426 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1031709006427 ATP binding site [chemical binding]; other site 1031709006428 putative Mg++ binding site [ion binding]; other site 1031709006429 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1031709006430 nucleotide binding region [chemical binding]; other site 1031709006431 ATP-binding site [chemical binding]; other site 1031709006432 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 1031709006433 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 1031709006434 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1031709006435 FeS/SAM binding site; other site 1031709006436 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK07111 1031709006437 ATP cone domain; Region: ATP-cone; pfam03477 1031709006438 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1031709006439 Class III ribonucleotide reductase; Region: RNR_III; cd01675 1031709006440 active site 1031709006441 Zn binding site [ion binding]; other site 1031709006442 glycine loop; other site 1031709006443 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1031709006444 substrate binding site [chemical binding]; other site 1031709006445 Cutinase; Region: Cutinase; pfam01083 1031709006446 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1031709006447 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1031709006448 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1031709006449 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1031709006450 NodB motif; other site 1031709006451 active site 1031709006452 catalytic site [active] 1031709006453 metal binding site [ion binding]; metal-binding site 1031709006454 TIGR03943 family protein; Region: TIGR03943 1031709006455 Predicted permease; Region: DUF318; cl17795 1031709006456 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1031709006457 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1031709006458 NodB motif; other site 1031709006459 active site 1031709006460 catalytic site [active] 1031709006461 metal binding site [ion binding]; metal-binding site 1031709006462 integral membrane protein MviN; Region: mviN; TIGR01695 1031709006463 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1031709006464 aspartate kinase; Reviewed; Region: PRK06635 1031709006465 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1031709006466 putative nucleotide binding site [chemical binding]; other site 1031709006467 putative catalytic residues [active] 1031709006468 putative Mg ion binding site [ion binding]; other site 1031709006469 putative aspartate binding site [chemical binding]; other site 1031709006470 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1031709006471 putative allosteric regulatory site; other site 1031709006472 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1031709006473 putative allosteric regulatory residue; other site 1031709006474 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1031709006475 Transglycosylase; Region: Transgly; pfam00912 1031709006476 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1031709006477 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 1031709006478 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1031709006479 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1031709006480 putative active site [active] 1031709006481 putative metal binding site [ion binding]; other site 1031709006482 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1031709006483 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1031709006484 proposed catalytic triad [active] 1031709006485 conserved cys residue [active] 1031709006486 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1031709006487 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1031709006488 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1031709006489 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1031709006490 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1031709006491 ABC-ATPase subunit interface; other site 1031709006492 putative PBP binding loops; other site 1031709006493 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1031709006494 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1031709006495 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1031709006496 dimer interface [polypeptide binding]; other site 1031709006497 conserved gate region; other site 1031709006498 putative PBP binding loops; other site 1031709006499 ABC-ATPase subunit interface; other site 1031709006500 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1031709006501 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1031709006502 Walker A/P-loop; other site 1031709006503 ATP binding site [chemical binding]; other site 1031709006504 Q-loop/lid; other site 1031709006505 ABC transporter signature motif; other site 1031709006506 Walker B; other site 1031709006507 D-loop; other site 1031709006508 H-loop/switch region; other site 1031709006509 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1031709006510 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1031709006511 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1031709006512 Walker A/P-loop; other site 1031709006513 ATP binding site [chemical binding]; other site 1031709006514 Q-loop/lid; other site 1031709006515 ABC transporter signature motif; other site 1031709006516 Walker B; other site 1031709006517 D-loop; other site 1031709006518 H-loop/switch region; other site 1031709006519 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1031709006520 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1031709006521 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1031709006522 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1031709006523 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1031709006524 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1031709006525 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1031709006526 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1031709006527 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1031709006528 urocanate hydratase; Provisional; Region: PRK05414 1031709006529 urocanate hydratase; Provisional; Region: PRK05414 1031709006530 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1031709006531 allantoate amidohydrolase; Reviewed; Region: PRK09290 1031709006532 active site 1031709006533 metal binding site [ion binding]; metal-binding site 1031709006534 dimer interface [polypeptide binding]; other site 1031709006535 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 1031709006536 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1031709006537 active site 1031709006538 imidazolonepropionase; Provisional; Region: PRK14085 1031709006539 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 1031709006540 active site 1031709006541 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1031709006542 active sites [active] 1031709006543 tetramer interface [polypeptide binding]; other site 1031709006544 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 1031709006545 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09755 1031709006546 NAD-dependent deacetylase; Provisional; Region: PRK00481 1031709006547 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 1031709006548 NAD+ binding site [chemical binding]; other site 1031709006549 substrate binding site [chemical binding]; other site 1031709006550 Zn binding site [ion binding]; other site 1031709006551 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1031709006552 Bacterial SH3 domain; Region: SH3_3; pfam08239 1031709006553 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1031709006554 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1031709006555 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 1031709006556 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1031709006557 potential frameshift: common BLAST hit: gi|295131698|ref|YP_003582361.1| TrkA-C domain protein 1031709006558 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1031709006559 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1031709006560 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1031709006561 nucleoside/Zn binding site; other site 1031709006562 dimer interface [polypeptide binding]; other site 1031709006563 catalytic motif [active] 1031709006564 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 1031709006565 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1031709006566 active site 1031709006567 Uncharacterized conserved protein [Function unknown]; Region: COG3777 1031709006568 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1031709006569 active site 1031709006570 catalytic site [active] 1031709006571 PA2301 is an uncharacterized Pseudomonas aeruginosa protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's...; Region: PA2301; cd04939 1031709006572 putative deacylase active site [active] 1031709006573 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1031709006574 K+ potassium transporter; Region: K_trans; pfam02705 1031709006575 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1031709006576 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1031709006577 catalytic triad [active] 1031709006578 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1031709006579 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1031709006580 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1031709006581 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1031709006582 DNA binding site [nucleotide binding] 1031709006583 domain linker motif; other site 1031709006584 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 1031709006585 ligand binding site [chemical binding]; other site 1031709006586 dimerization interface (open form) [polypeptide binding]; other site 1031709006587 dimerization interface (closed form) [polypeptide binding]; other site 1031709006588 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1031709006589 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 1031709006590 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u2; cd11478 1031709006591 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1031709006592 Na binding site [ion binding]; other site 1031709006593 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1031709006594 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 1031709006595 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 1031709006596 NAD(P) binding site [chemical binding]; other site 1031709006597 argininosuccinate synthase; Validated; Region: PRK05370 1031709006598 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1031709006599 putative substrate translocation pore; other site 1031709006600 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1031709006601 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1031709006602 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1031709006603 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1031709006604 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1031709006605 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1031709006606 active site 1031709006607 motif I; other site 1031709006608 motif II; other site 1031709006609 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1031709006610 thiazolylpeptide-type bacteriocin precursor; Region: thiopep_precurs; TIGR03892 1031709006611 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1031709006612 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1031709006613 Walker A/P-loop; other site 1031709006614 ATP binding site [chemical binding]; other site 1031709006615 Q-loop/lid; other site 1031709006616 ABC transporter signature motif; other site 1031709006617 Walker B; other site 1031709006618 D-loop; other site 1031709006619 H-loop/switch region; other site 1031709006620 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1031709006621 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1031709006622 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1031709006623 non-specific DNA binding site [nucleotide binding]; other site 1031709006624 salt bridge; other site 1031709006625 sequence-specific DNA binding site [nucleotide binding]; other site 1031709006626 Cupin domain; Region: Cupin_2; pfam07883 1031709006627 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 1031709006628 B3/4 domain; Region: B3_4; pfam03483 1031709006629 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1031709006630 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1031709006631 Na binding site [ion binding]; other site 1031709006632 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 1031709006633 CIDE_N domain, found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) proteins, as well as CAD nuclease (caspase-activated DNase/DNA fragmentation factor, DFF40) and its inhibitor, ICAD(DFF45). These proteins are associated with...; Region: CIDE_N; cl02541 1031709006634 oxidoreductase; Provisional; Region: PRK10015 1031709006635 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1031709006636 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1031709006637 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1031709006638 Ligand binding site [chemical binding]; other site 1031709006639 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1031709006640 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1031709006641 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1031709006642 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1031709006643 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1031709006644 active site 1031709006645 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1031709006646 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1031709006647 Bacterial transcriptional regulator; Region: IclR; pfam01614 1031709006648 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 1031709006649 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1031709006650 nucleotide binding site/active site [active] 1031709006651 HIT family signature motif; other site 1031709006652 catalytic residue [active] 1031709006653 seryl-tRNA synthetase; Provisional; Region: PRK05431 1031709006654 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1031709006655 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1031709006656 dimer interface [polypeptide binding]; other site 1031709006657 active site 1031709006658 motif 1; other site 1031709006659 motif 2; other site 1031709006660 motif 3; other site 1031709006661 PRC-barrel domain; Region: PRC; pfam05239 1031709006662 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 1031709006663 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1031709006664 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 1031709006665 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1031709006666 phosphate binding motif [ion binding]; other site 1031709006667 Siderophore-interacting protein; Region: SIP; pfam04954 1031709006668 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 1031709006669 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1031709006670 Ferritin-like domain; Region: Ferritin; pfam00210 1031709006671 ferroxidase diiron center [ion binding]; other site 1031709006672 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1031709006673 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1031709006674 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1031709006675 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1031709006676 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1031709006677 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1031709006678 dimer interface [polypeptide binding]; other site 1031709006679 ssDNA binding site [nucleotide binding]; other site 1031709006680 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1031709006681 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1031709006682 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1031709006683 active site residue [active] 1031709006684 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1031709006685 active site 1031709006686 phosphorylation site [posttranslational modification] 1031709006687 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 1031709006688 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1031709006689 active site 1031709006690 P-loop; other site 1031709006691 phosphorylation site [posttranslational modification] 1031709006692 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1031709006693 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1031709006694 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1031709006695 acyl-activating enzyme (AAE) consensus motif; other site 1031709006696 putative AMP binding site [chemical binding]; other site 1031709006697 putative active site [active] 1031709006698 putative CoA binding site [chemical binding]; other site 1031709006699 endonuclease IV; Provisional; Region: PRK01060 1031709006700 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1031709006701 DNA interaction; other site 1031709006702 Metal-binding active site; metal-binding site 1031709006703 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1031709006704 classical (c) SDRs; Region: SDR_c; cd05233 1031709006705 NAD(P) binding site [chemical binding]; other site 1031709006706 active site 1031709006707 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1031709006708 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1031709006709 putative acyl-acceptor binding pocket; other site 1031709006710 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 1031709006711 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1031709006712 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1031709006713 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1031709006714 G5 domain; Region: G5; pfam07501 1031709006715 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1031709006716 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1031709006717 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1031709006718 metal-binding site [ion binding] 1031709006719 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1031709006720 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1031709006721 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1031709006722 metal-binding site [ion binding] 1031709006723 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 1031709006724 putative homodimer interface [polypeptide binding]; other site 1031709006725 putative homotetramer interface [polypeptide binding]; other site 1031709006726 putative allosteric switch controlling residues; other site 1031709006727 putative metal binding site [ion binding]; other site 1031709006728 putative homodimer-homodimer interface [polypeptide binding]; other site 1031709006729 replicative DNA helicase; Region: DnaB; TIGR00665 1031709006730 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1031709006731 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1031709006732 Walker A motif; other site 1031709006733 ATP binding site [chemical binding]; other site 1031709006734 Walker B motif; other site 1031709006735 DNA binding loops [nucleotide binding] 1031709006736 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 1031709006737 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 1031709006738 putative NAD(P) binding site [chemical binding]; other site 1031709006739 dimer interface [polypeptide binding]; other site 1031709006740 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1031709006741 active site 1031709006742 DNA binding site [nucleotide binding] 1031709006743 sn-glycerol-3-phosphate dehydrogenase subunit C; Provisional; Region: glpC; PRK11168 1031709006744 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 1031709006745 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1031709006746 glycerol-3-phosphate dehydrogenase, anaerobic, A subunit; Region: glycerol3P_GlpA; TIGR03377 1031709006747 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1031709006748 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1031709006749 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1031709006750 dimerization interface [polypeptide binding]; other site 1031709006751 ligand binding site [chemical binding]; other site 1031709006752 NADP binding site [chemical binding]; other site 1031709006753 catalytic site [active] 1031709006754 MarR family; Region: MarR_2; cl17246 1031709006755 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1031709006756 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 1031709006757 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1031709006758 Cl- selectivity filter; other site 1031709006759 Cl- binding residues [ion binding]; other site 1031709006760 pore gating glutamate residue; other site 1031709006761 dimer interface [polypeptide binding]; other site 1031709006762 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1031709006763 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1031709006764 MarR family; Region: MarR_2; pfam12802 1031709006765 MarR family; Region: MarR_2; cl17246 1031709006766 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1031709006767 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1031709006768 active site 1031709006769 metal binding site [ion binding]; metal-binding site 1031709006770 Predicted ATPases [General function prediction only]; Region: COG1106 1031709006771 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1031709006772 Uncharacterized conserved protein [Function unknown]; Region: COG4717 1031709006773 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1031709006774 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 1031709006775 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1031709006776 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1031709006777 WHG domain; Region: WHG; pfam13305 1031709006778 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1031709006779 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1031709006780 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1031709006781 catalytic residue [active] 1031709006782 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1031709006783 putative deacylase active site [active] 1031709006784 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1031709006785 NAD synthetase; Reviewed; Region: nadE; PRK02628 1031709006786 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 1031709006787 multimer interface [polypeptide binding]; other site 1031709006788 active site 1031709006789 catalytic triad [active] 1031709006790 protein interface 1 [polypeptide binding]; other site 1031709006791 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1031709006792 homodimer interface [polypeptide binding]; other site 1031709006793 NAD binding pocket [chemical binding]; other site 1031709006794 ATP binding pocket [chemical binding]; other site 1031709006795 Mg binding site [ion binding]; other site 1031709006796 active-site loop [active] 1031709006797 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 1031709006798 6-phosphofructokinase, eukaryotic type; Region: 6PF1K_euk; TIGR02478 1031709006799 active site 1031709006800 ADP/pyrophosphate binding site [chemical binding]; other site 1031709006801 dimerization interface [polypeptide binding]; other site 1031709006802 allosteric effector site; other site 1031709006803 fructose-1,6-bisphosphate binding site; other site 1031709006804 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1031709006805 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1031709006806 hexamer interface [polypeptide binding]; other site 1031709006807 ligand binding site [chemical binding]; other site 1031709006808 putative active site [active] 1031709006809 NAD(P) binding site [chemical binding]; other site 1031709006810 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 1031709006811 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 1031709006812 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1031709006813 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1031709006814 Bacterial SH3 domain; Region: SH3_3; pfam08239 1031709006815 Bacterial SH3 domain; Region: SH3_3; pfam08239 1031709006816 Bacterial SH3 domain; Region: SH3_4; pfam06347 1031709006817 Bacterial SH3 domain; Region: SH3_4; pfam06347 1031709006818 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 1031709006819 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1031709006820 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1031709006821 dimer interface [polypeptide binding]; other site 1031709006822 Citrate synthase; Region: Citrate_synt; pfam00285 1031709006823 active site 1031709006824 citrylCoA binding site [chemical binding]; other site 1031709006825 NADH binding [chemical binding]; other site 1031709006826 cationic pore residues; other site 1031709006827 oxalacetate/citrate binding site [chemical binding]; other site 1031709006828 coenzyme A binding site [chemical binding]; other site 1031709006829 catalytic triad [active] 1031709006830 adenosine deaminase; Provisional; Region: PRK09358 1031709006831 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1031709006832 active site 1031709006833 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1031709006834 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1031709006835 hexamer interface [polypeptide binding]; other site 1031709006836 ligand binding site [chemical binding]; other site 1031709006837 putative active site [active] 1031709006838 NAD(P) binding site [chemical binding]; other site 1031709006839 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1031709006840 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1031709006841 AsnC family; Region: AsnC_trans_reg; pfam01037 1031709006842 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1031709006843 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1031709006844 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1031709006845 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1031709006846 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1031709006847 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 1031709006848 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1031709006849 catalytic residue [active] 1031709006850 D-Lysine 5,6-aminomutase alpha subunit; Region: Lys-AminoMut_A; pfam09043 1031709006851 D-Lysine 5,6-aminomutase alpha subunit; Region: Lys-AminoMut_A; pfam09043 1031709006852 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1031709006853 B12 binding site [chemical binding]; other site 1031709006854 MutL protein; Region: MutL; pfam13941 1031709006855 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 1031709006856 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815 1031709006857 active site 1031709006858 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1031709006859 dimer interface [polypeptide binding]; other site 1031709006860 substrate binding site [chemical binding]; other site 1031709006861 catalytic residue [active] 1031709006862 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 1031709006863 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 1031709006864 alanine racemase; Reviewed; Region: alr; PRK00053 1031709006865 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1031709006866 active site 1031709006867 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1031709006868 dimer interface [polypeptide binding]; other site 1031709006869 substrate binding site [chemical binding]; other site 1031709006870 catalytic residues [active] 1031709006871 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1031709006872 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 1031709006873 active site 1031709006874 substrate binding site [chemical binding]; other site 1031709006875 metal binding site [ion binding]; metal-binding site 1031709006876 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1031709006877 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 1031709006878 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1031709006879 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 1031709006880 active site 1031709006881 Substrate binding site; other site 1031709006882 Mg++ binding site; other site 1031709006883 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1031709006884 putative active site [active] 1031709006885 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1031709006886 Class II fumarases; Region: Fumarase_classII; cd01362 1031709006887 active site 1031709006888 tetramer interface [polypeptide binding]; other site 1031709006889 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1031709006890 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1031709006891 dimer interface [polypeptide binding]; other site 1031709006892 conserved gate region; other site 1031709006893 putative PBP binding loops; other site 1031709006894 ABC-ATPase subunit interface; other site 1031709006895 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1031709006896 dimer interface [polypeptide binding]; other site 1031709006897 conserved gate region; other site 1031709006898 putative PBP binding loops; other site 1031709006899 ABC-ATPase subunit interface; other site 1031709006900 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1031709006901 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1031709006902 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1031709006903 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1031709006904 DNA binding site [nucleotide binding] 1031709006905 domain linker motif; other site 1031709006906 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 1031709006907 putative dimerization interface [polypeptide binding]; other site 1031709006908 putative ligand binding site [chemical binding]; other site 1031709006909 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 1031709006910 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1031709006911 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1031709006912 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1031709006913 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 1031709006914 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1031709006915 active site 1031709006916 NTP binding site [chemical binding]; other site 1031709006917 metal binding triad [ion binding]; metal-binding site 1031709006918 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1031709006919 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1031709006920 Zn2+ binding site [ion binding]; other site 1031709006921 Mg2+ binding site [ion binding]; other site 1031709006922 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1031709006923 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1031709006924 ATP binding site [chemical binding]; other site 1031709006925 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1031709006926 glycerol kinase; Provisional; Region: glpK; PRK00047 1031709006927 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 1031709006928 N- and C-terminal domain interface [polypeptide binding]; other site 1031709006929 active site 1031709006930 MgATP binding site [chemical binding]; other site 1031709006931 catalytic site [active] 1031709006932 metal binding site [ion binding]; metal-binding site 1031709006933 putative homotetramer interface [polypeptide binding]; other site 1031709006934 glycerol binding site [chemical binding]; other site 1031709006935 homodimer interface [polypeptide binding]; other site 1031709006936 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 1031709006937 amphipathic channel; other site 1031709006938 Asn-Pro-Ala signature motifs; other site 1031709006939 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1031709006940 Helix-turn-helix domain; Region: HTH_28; pfam13518 1031709006941 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1031709006942 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1031709006943 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1031709006944 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 1031709006945 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1031709006946 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1031709006947 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1031709006948 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 1031709006949 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1031709006950 probable active site [active] 1031709006951 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1031709006952 putative substrate translocation pore; other site 1031709006953 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1031709006954 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1031709006955 substrate binding pocket [chemical binding]; other site 1031709006956 OsmC-like protein; Region: OsmC; pfam02566 1031709006957 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1031709006958 catalytic residues [active] 1031709006959 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1031709006960 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1031709006961 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1031709006962 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1031709006963 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 1031709006964 non-specific DNA interactions [nucleotide binding]; other site 1031709006965 DNA binding site [nucleotide binding] 1031709006966 sequence specific DNA binding site [nucleotide binding]; other site 1031709006967 putative cAMP binding site [chemical binding]; other site 1031709006968 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1031709006969 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1031709006970 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1031709006971 TPP-binding site [chemical binding]; other site 1031709006972 dimer interface [polypeptide binding]; other site 1031709006973 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1031709006974 PYR/PP interface [polypeptide binding]; other site 1031709006975 dimer interface [polypeptide binding]; other site 1031709006976 TPP binding site [chemical binding]; other site 1031709006977 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1031709006978 ribulokinase; Provisional; Region: PRK04123 1031709006979 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 1031709006980 N- and C-terminal domain interface [polypeptide binding]; other site 1031709006981 active site 1031709006982 MgATP binding site [chemical binding]; other site 1031709006983 catalytic site [active] 1031709006984 metal binding site [ion binding]; metal-binding site 1031709006985 carbohydrate binding site [chemical binding]; other site 1031709006986 homodimer interface [polypeptide binding]; other site 1031709006987 Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175 1031709006988 active site 1031709006989 metal binding site [ion binding]; metal-binding site 1031709006990 Carbohydrate kinase and ribulose-phosphate 3-epimerase fusion proteins-like; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CarbK-RPE_like; cd07783 1031709006991 Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069 1031709006992 N- and C-terminal domain interface [polypeptide binding]; other site 1031709006993 active site 1031709006994 MgATP binding site [chemical binding]; other site 1031709006995 catalytic site [active] 1031709006996 metal binding site [ion binding]; metal-binding site 1031709006997 putative carbohydrate binding site [chemical binding]; other site 1031709006998 putative homodimer interface [polypeptide binding]; other site 1031709006999 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1031709007000 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1031709007001 active site 1031709007002 motif I; other site 1031709007003 motif II; other site 1031709007004 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1031709007005 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 1031709007006 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 1031709007007 active site 1031709007008 Zn2+ binding site [ion binding]; other site 1031709007009 intersubunit interface [polypeptide binding]; other site 1031709007010 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1031709007011 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1031709007012 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1031709007013 mannonate dehydratase; Provisional; Region: PRK03906 1031709007014 mannonate dehydratase; Region: uxuA; TIGR00695 1031709007015 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1031709007016 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1031709007017 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1031709007018 glucuronate isomerase; Reviewed; Region: PRK02925 1031709007019 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 1031709007020 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1031709007021 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1031709007022 DNA binding site [nucleotide binding] 1031709007023 domain linker motif; other site 1031709007024 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1031709007025 dimerization interface [polypeptide binding]; other site 1031709007026 ligand binding site [chemical binding]; other site 1031709007027 MFS/sugar transport protein; Region: MFS_2; pfam13347 1031709007028 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1031709007029 putative alpha-glucosidase; Provisional; Region: PRK10658 1031709007030 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1031709007031 Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599 1031709007032 putative active site [active] 1031709007033 putative catalytic site [active] 1031709007034 beta-D-glucuronidase; Provisional; Region: PRK10150 1031709007035 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1031709007036 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1031709007037 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1031709007038 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 1031709007039 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1031709007040 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1031709007041 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1031709007042 homodimer interface [polypeptide binding]; other site 1031709007043 catalytic residue [active] 1031709007044 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 1031709007045 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1031709007046 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1031709007047 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 1031709007048 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 1031709007049 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1031709007050 ParB-like nuclease domain; Region: ParB; smart00470 1031709007051 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1031709007052 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1031709007053 P-loop; other site 1031709007054 Magnesium ion binding site [ion binding]; other site 1031709007055 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1031709007056 Magnesium ion binding site [ion binding]; other site 1031709007057 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 1031709007058 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 1031709007059 Alanine racemase, N-terminal domain; Region: Ala_racemase_N; pfam01168 1031709007060 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1031709007061 catalytic residue [active] 1031709007062 FemAB family; Region: FemAB; pfam02388 1031709007063 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1031709007064 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 1031709007065 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1031709007066 G-X-X-G motif; other site 1031709007067 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1031709007068 RxxxH motif; other site 1031709007069 putative inner membrane protein translocase component YidC; Provisional; Region: PRK01315 1031709007070 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1031709007071 Haemolytic domain; Region: Haemolytic; pfam01809 1031709007072 Ribonuclease P; Region: Ribonuclease_P; pfam00825 1031709007073 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399