-- dump date 20140620_000826 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1134454000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1134454000002 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 1134454000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1134454000004 Walker A motif; other site 1134454000005 ATP binding site [chemical binding]; other site 1134454000006 Walker B motif; other site 1134454000007 arginine finger; other site 1134454000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1134454000009 DnaA box-binding interface [nucleotide binding]; other site 1134454000010 DNA polymerase III subunit beta; Validated; Region: PRK07761 1134454000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1134454000012 putative DNA binding surface [nucleotide binding]; other site 1134454000013 dimer interface [polypeptide binding]; other site 1134454000014 beta-clamp/clamp loader binding surface; other site 1134454000015 beta-clamp/translesion DNA polymerase binding surface; other site 1134454000016 recombination protein F; Reviewed; Region: recF; PRK00064 1134454000017 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1134454000018 Walker A/P-loop; other site 1134454000019 ATP binding site [chemical binding]; other site 1134454000020 Q-loop/lid; other site 1134454000021 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1134454000022 ABC transporter signature motif; other site 1134454000023 Walker B; other site 1134454000024 D-loop; other site 1134454000025 H-loop/switch region; other site 1134454000026 Protein of unknown function (DUF721); Region: DUF721; cl02324 1134454000027 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 1134454000028 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1134454000029 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1134454000030 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1134454000031 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1134454000032 Mg2+ binding site [ion binding]; other site 1134454000033 G-X-G motif; other site 1134454000034 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1134454000035 anchoring element; other site 1134454000036 dimer interface [polypeptide binding]; other site 1134454000037 ATP binding site [chemical binding]; other site 1134454000038 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1134454000039 active site 1134454000040 putative metal-binding site [ion binding]; other site 1134454000041 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1134454000042 DNA gyrase subunit A; Validated; Region: PRK05560 1134454000043 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1134454000044 CAP-like domain; other site 1134454000045 active site 1134454000046 primary dimer interface [polypeptide binding]; other site 1134454000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1134454000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1134454000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1134454000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1134454000051 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1134454000052 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 1134454000053 A subgroup of L-lactate dehydrogenases; Region: LDH_3; cd05290 1134454000054 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 1134454000055 NAD binding site [chemical binding]; other site 1134454000056 dimer interface [polypeptide binding]; other site 1134454000057 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1134454000058 substrate binding site [chemical binding]; other site 1134454000059 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1134454000060 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1134454000061 DNA binding site [nucleotide binding] 1134454000062 domain linker motif; other site 1134454000063 Ligand-binding domain of DNA-binding regulatory protein from Corynebacterium glutamicum which has a unique ability to produce significant amounts of L-glutamate directly from cheap sugar and ammonia; Region: PBP1_LacI_like_13; cd06299 1134454000064 dimerization interface [polypeptide binding]; other site 1134454000065 putative ligand binding site [chemical binding]; other site 1134454000066 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1134454000067 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1134454000068 Walker A/P-loop; other site 1134454000069 ATP binding site [chemical binding]; other site 1134454000070 Q-loop/lid; other site 1134454000071 ABC transporter signature motif; other site 1134454000072 Walker B; other site 1134454000073 D-loop; other site 1134454000074 H-loop/switch region; other site 1134454000075 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1134454000076 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1134454000077 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1134454000078 TM-ABC transporter signature motif; other site 1134454000079 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 1134454000080 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1134454000081 ligand binding site [chemical binding]; other site 1134454000082 dimerization interface [polypeptide binding]; other site 1134454000083 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1134454000084 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1134454000085 substrate binding site [chemical binding]; other site 1134454000086 dimer interface [polypeptide binding]; other site 1134454000087 ATP binding site [chemical binding]; other site 1134454000088 D-ribose pyranase; Provisional; Region: PRK11797 1134454000089 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 1134454000090 active site 1134454000091 P-loop; other site 1134454000092 phosphorylation site [posttranslational modification] 1134454000093 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1134454000094 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1134454000095 haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549 1134454000096 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1134454000097 active site 1134454000098 motif I; other site 1134454000099 motif II; other site 1134454000100 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1134454000101 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1134454000102 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1134454000103 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 1134454000104 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1134454000105 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1134454000106 homodimer interface [polypeptide binding]; other site 1134454000107 catalytic residue [active] 1134454000108 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 1134454000109 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 1134454000110 active site 1134454000111 nucleophile elbow; other site 1134454000112 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1134454000113 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1134454000114 SAF domain; Region: SAF; pfam08666 1134454000115 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 1134454000116 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1134454000117 Walker A motif; other site 1134454000118 ATP binding site [chemical binding]; other site 1134454000119 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1134454000120 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1134454000121 Bacterial transcriptional activator domain; Region: BTAD; smart01043 1134454000122 H+ Antiporter protein; Region: 2A0121; TIGR00900 1134454000123 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 1134454000124 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 1134454000125 Potassium binding sites [ion binding]; other site 1134454000126 Cesium cation binding sites [ion binding]; other site 1134454000127 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 1134454000128 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1134454000129 FtsX-like permease family; Region: FtsX; pfam02687 1134454000130 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1134454000131 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1134454000132 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1134454000133 Walker A/P-loop; other site 1134454000134 ATP binding site [chemical binding]; other site 1134454000135 Q-loop/lid; other site 1134454000136 ABC transporter signature motif; other site 1134454000137 Walker B; other site 1134454000138 D-loop; other site 1134454000139 H-loop/switch region; other site 1134454000140 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1134454000141 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1134454000142 active site 1134454000143 phosphorylation site [posttranslational modification] 1134454000144 intermolecular recognition site; other site 1134454000145 dimerization interface [polypeptide binding]; other site 1134454000146 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1134454000147 DNA binding residues [nucleotide binding] 1134454000148 dimerization interface [polypeptide binding]; other site 1134454000149 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1134454000150 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1134454000151 dimer interface [polypeptide binding]; other site 1134454000152 conserved gate region; other site 1134454000153 putative PBP binding loops; other site 1134454000154 ABC-ATPase subunit interface; other site 1134454000155 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1134454000156 dimer interface [polypeptide binding]; other site 1134454000157 conserved gate region; other site 1134454000158 putative PBP binding loops; other site 1134454000159 ABC-ATPase subunit interface; other site 1134454000160 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1134454000161 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1134454000162 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1134454000163 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1134454000164 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1134454000165 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 1134454000166 NAD binding site [chemical binding]; other site 1134454000167 sugar binding site [chemical binding]; other site 1134454000168 divalent metal binding site [ion binding]; other site 1134454000169 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1134454000170 dimer interface [polypeptide binding]; other site 1134454000171 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 1134454000172 active site 1134454000173 catalytic site [active] 1134454000174 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 1134454000175 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 1134454000176 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 1134454000177 Sulfatase; Region: Sulfatase; cl17466 1134454000178 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 1134454000179 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1134454000180 motif II; other site 1134454000181 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 1134454000182 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 1134454000183 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 1134454000184 active site 1134454000185 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1134454000186 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1134454000187 substrate binding site [chemical binding]; other site 1134454000188 ATP binding site [chemical binding]; other site 1134454000189 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1134454000190 Histidine kinase; Region: HisKA_3; pfam07730 1134454000191 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1134454000192 ATP binding site [chemical binding]; other site 1134454000193 Mg2+ binding site [ion binding]; other site 1134454000194 G-X-G motif; other site 1134454000195 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1134454000196 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1134454000197 NAD(P) binding site [chemical binding]; other site 1134454000198 active site 1134454000199 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1134454000200 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1134454000201 MMPL family; Region: MMPL; pfam03176 1134454000202 MMPL family; Region: MMPL; pfam03176 1134454000203 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1134454000204 Predicted membrane protein [Function unknown]; Region: COG1511 1134454000205 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1134454000206 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1134454000207 Walker A/P-loop; other site 1134454000208 ATP binding site [chemical binding]; other site 1134454000209 Q-loop/lid; other site 1134454000210 ABC transporter signature motif; other site 1134454000211 Walker B; other site 1134454000212 D-loop; other site 1134454000213 H-loop/switch region; other site 1134454000214 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1134454000215 S-adenosylmethionine binding site [chemical binding]; other site 1134454000216 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 1134454000217 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 1134454000218 putative ligand binding residues [chemical binding]; other site 1134454000219 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1134454000220 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1134454000221 ABC-ATPase subunit interface; other site 1134454000222 dimer interface [polypeptide binding]; other site 1134454000223 putative PBP binding regions; other site 1134454000224 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1134454000225 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1134454000226 ABC transporter signature motif; other site 1134454000227 Walker B; other site 1134454000228 D-loop; other site 1134454000229 H-loop/switch region; other site 1134454000230 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1134454000231 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1134454000232 tetramerization interface [polypeptide binding]; other site 1134454000233 NAD(P) binding site [chemical binding]; other site 1134454000234 catalytic residues [active] 1134454000235 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1134454000236 Putative ClC chloride channel. Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033 1134454000237 putative ion selectivity filter; other site 1134454000238 putative pore gating glutamate residue; other site 1134454000239 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1134454000240 homodimer interface [polypeptide binding]; other site 1134454000241 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 1134454000242 active site pocket [active] 1134454000243 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1134454000244 DNA binding residues [nucleotide binding] 1134454000245 Lacto-N-biose phosphorylase; Region: Lact_bio_phlase; pfam09508 1134454000246 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase; Region: TIGR02336 1134454000247 MarR family; Region: MarR_2; pfam12802 1134454000248 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1134454000249 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1134454000250 carbohydrate ABC transporter substrate-binding protein, CPR_0540 family; Region: bind_CPR_0540; TIGR03850 1134454000251 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1134454000252 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1134454000253 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1134454000254 dimer interface [polypeptide binding]; other site 1134454000255 conserved gate region; other site 1134454000256 putative PBP binding loops; other site 1134454000257 ABC-ATPase subunit interface; other site 1134454000258 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1134454000259 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1134454000260 dimer interface [polypeptide binding]; other site 1134454000261 conserved gate region; other site 1134454000262 putative PBP binding loops; other site 1134454000263 ABC-ATPase subunit interface; other site 1134454000264 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1134454000265 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1134454000266 DNA binding site [nucleotide binding] 1134454000267 domain linker motif; other site 1134454000268 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 1134454000269 ligand binding site [chemical binding]; other site 1134454000270 dimerization interface (open form) [polypeptide binding]; other site 1134454000271 dimerization interface (closed form) [polypeptide binding]; other site 1134454000272 6-phosphofructokinase; Provisional; Region: PRK03202 1134454000273 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1134454000274 active site 1134454000275 ADP/pyrophosphate binding site [chemical binding]; other site 1134454000276 dimerization interface [polypeptide binding]; other site 1134454000277 allosteric effector site; other site 1134454000278 fructose-1,6-bisphosphate binding site; other site 1134454000279 Predicted transcriptional regulator [Transcription]; Region: COG2345 1134454000280 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1134454000281 putative DNA binding site [nucleotide binding]; other site 1134454000282 putative Zn2+ binding site [ion binding]; other site 1134454000283 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 1134454000284 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 1134454000285 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1134454000286 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1134454000287 Aspartase; Region: Aspartase; cd01357 1134454000288 active sites [active] 1134454000289 tetramer interface [polypeptide binding]; other site 1134454000290 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 1134454000291 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 1134454000292 Predicted acetyltransferase [General function prediction only]; Region: COG2388 1134454000293 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1134454000294 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 1134454000295 heme binding pocket [chemical binding]; other site 1134454000296 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1134454000297 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1134454000298 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1134454000299 Walker A/P-loop; other site 1134454000300 ATP binding site [chemical binding]; other site 1134454000301 Q-loop/lid; other site 1134454000302 ABC transporter signature motif; other site 1134454000303 Walker B; other site 1134454000304 D-loop; other site 1134454000305 H-loop/switch region; other site 1134454000306 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1134454000307 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1134454000308 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1134454000309 Q-loop/lid; other site 1134454000310 ABC transporter signature motif; other site 1134454000311 Walker B; other site 1134454000312 D-loop; other site 1134454000313 H-loop/switch region; other site 1134454000314 Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081 1134454000315 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1134454000316 Walker A motif; other site 1134454000317 ATP binding site [chemical binding]; other site 1134454000318 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 1134454000319 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1134454000320 Walker A motif; other site 1134454000321 ATP binding site [chemical binding]; other site 1134454000322 Walker B motif; other site 1134454000323 arginine finger; other site 1134454000324 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 1134454000325 metal ion-dependent adhesion site (MIDAS); other site 1134454000326 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1134454000327 CobN/Magnesium Chelatase; Region: CobN-Mg_chel; pfam02514 1134454000328 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1134454000329 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1134454000330 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1134454000331 FeS/SAM binding site; other site 1134454000332 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1134454000333 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1134454000334 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1134454000335 Walker A/P-loop; other site 1134454000336 ATP binding site [chemical binding]; other site 1134454000337 Q-loop/lid; other site 1134454000338 ABC transporter signature motif; other site 1134454000339 Walker B; other site 1134454000340 D-loop; other site 1134454000341 H-loop/switch region; other site 1134454000342 FecCD transport family; Region: FecCD; pfam01032 1134454000343 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1134454000344 ABC-ATPase subunit interface; other site 1134454000345 dimer interface [polypeptide binding]; other site 1134454000346 putative PBP binding regions; other site 1134454000347 Periplasmic binding protein TroA_d. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_d; cd01141 1134454000348 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1134454000349 putative ligand binding site [chemical binding]; other site 1134454000350 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1134454000351 Periplasmic binding protein TroA_d. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_d; cd01141 1134454000352 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1134454000353 putative ligand binding site [chemical binding]; other site 1134454000354 myosin-cross-reactive antigen; Provisional; Region: PRK13977 1134454000355 multifunctional hydroxymethylpyrimidine phosphokinase/4-amino-5-aminomethyl-2-methylpyrimidine hydrolase; Provisional; Region: PRK14713 1134454000356 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1134454000357 dimer interface [polypeptide binding]; other site 1134454000358 substrate binding site [chemical binding]; other site 1134454000359 ATP binding site [chemical binding]; other site 1134454000360 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 1134454000361 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1134454000362 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1134454000363 thiamine phosphate binding site [chemical binding]; other site 1134454000364 active site 1134454000365 pyrophosphate binding site [ion binding]; other site 1134454000366 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 1134454000367 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 1134454000368 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1134454000369 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1134454000370 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 1134454000371 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1134454000372 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1134454000373 Ligand Binding Site [chemical binding]; other site 1134454000374 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1134454000375 dimer interface [polypeptide binding]; other site 1134454000376 phosphorylation site [posttranslational modification] 1134454000377 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1134454000378 ATP binding site [chemical binding]; other site 1134454000379 Mg2+ binding site [ion binding]; other site 1134454000380 G-X-G motif; other site 1134454000381 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1134454000382 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1134454000383 active site 1134454000384 phosphorylation site [posttranslational modification] 1134454000385 intermolecular recognition site; other site 1134454000386 dimerization interface [polypeptide binding]; other site 1134454000387 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1134454000388 DNA binding site [nucleotide binding] 1134454000389 EXLDI protein; Region: EXLDI; TIGR04342 1134454000390 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1134454000391 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1134454000392 Walker A/P-loop; other site 1134454000393 ATP binding site [chemical binding]; other site 1134454000394 Q-loop/lid; other site 1134454000395 ABC transporter signature motif; other site 1134454000396 Walker B; other site 1134454000397 D-loop; other site 1134454000398 H-loop/switch region; other site 1134454000399 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1134454000400 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1134454000401 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1134454000402 catalytic residues [active] 1134454000403 Recombinase; Region: Recombinase; pfam07508 1134454000404 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1134454000405 Homeodomain-like domain; Region: HTH_23; pfam13384 1134454000406 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1134454000407 substrate binding site [chemical binding]; other site 1134454000408 amidase catalytic site [active] 1134454000409 Zn binding residues [ion binding]; other site 1134454000410 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1134454000411 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1134454000412 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1134454000413 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1134454000414 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1134454000415 Transglycosylase; Region: Transgly; pfam00912 1134454000416 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1134454000417 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1134454000418 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 1134454000419 Mannosyltransferase (PIG-V)); Region: Mannosyl_trans2; pfam04188 1134454000420 This family is most closely related to the GT1 family of glycosyltransferases. AmsK is involved in the biosynthesis of amylovoran, which functions as a virulence factor. It functions as a glycosyl transferase which transfers galactose from UDP-galactose...; Region: GT1_AmsK_like; cd04946 1134454000421 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1134454000422 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1134454000423 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1134454000424 O-Antigen ligase; Region: Wzy_C; pfam04932 1134454000425 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1134454000426 putative trimer interface [polypeptide binding]; other site 1134454000427 putative CoA binding site [chemical binding]; other site 1134454000428 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 1134454000429 putative trimer interface [polypeptide binding]; other site 1134454000430 putative active site [active] 1134454000431 putative substrate binding site [chemical binding]; other site 1134454000432 putative CoA binding site [chemical binding]; other site 1134454000433 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1134454000434 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1134454000435 inhibitor-cofactor binding pocket; inhibition site 1134454000436 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1134454000437 catalytic residue [active] 1134454000438 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1134454000439 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1134454000440 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1134454000441 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 1134454000442 O-Antigen ligase; Region: Wzy_C; pfam04932 1134454000443 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1134454000444 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1134454000445 POT family; Region: PTR2; cl17359 1134454000446 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1134454000447 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1134454000448 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1134454000449 classical (c) SDRs; Region: SDR_c; cd05233 1134454000450 NAD(P) binding site [chemical binding]; other site 1134454000451 active site 1134454000452 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1134454000453 dimerization domain swap beta strand [polypeptide binding]; other site 1134454000454 regulatory protein interface [polypeptide binding]; other site 1134454000455 active site 1134454000456 regulatory phosphorylation site [posttranslational modification]; other site 1134454000457 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1134454000458 active site 1134454000459 phosphorylation site [posttranslational modification] 1134454000460 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1134454000461 active site 1134454000462 P-loop; other site 1134454000463 phosphorylation site [posttranslational modification] 1134454000464 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1134454000465 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1134454000466 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1134454000467 putative substrate binding site [chemical binding]; other site 1134454000468 putative ATP binding site [chemical binding]; other site 1134454000469 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1134454000470 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1134454000471 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1134454000472 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 1134454000473 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1134454000474 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1134454000475 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1134454000476 O-Antigen ligase; Region: Wzy_C; pfam04932 1134454000477 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1134454000478 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 1134454000479 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1134454000480 active site 1134454000481 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 1134454000482 homodimer interface [polypeptide binding]; other site 1134454000483 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1134454000484 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1134454000485 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1134454000486 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1134454000487 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1134454000488 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 1134454000489 nudix motif; other site 1134454000490 HrpA-like helicases [DNA replication, recombination, and repair]; Region: HrpA; COG1643 1134454000491 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1134454000492 ATP binding site [chemical binding]; other site 1134454000493 putative Mg++ binding site [ion binding]; other site 1134454000494 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1134454000495 nucleotide binding region [chemical binding]; other site 1134454000496 ATP-binding site [chemical binding]; other site 1134454000497 Helicase associated domain (HA2); Region: HA2; pfam04408 1134454000498 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 1134454000499 generic binding surface II; other site 1134454000500 generic binding surface I; other site 1134454000501 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1134454000502 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1134454000503 P-loop; other site 1134454000504 Magnesium ion binding site [ion binding]; other site 1134454000505 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1134454000506 Magnesium ion binding site [ion binding]; other site 1134454000507 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1134454000508 DNA binding residues [nucleotide binding] 1134454000509 AAA domain; Region: AAA_31; pfam13614 1134454000510 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1134454000511 CAAX protease self-immunity; Region: Abi; pfam02517 1134454000512 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 1134454000513 YcaO-like family; Region: YcaO; pfam02624 1134454000514 thiazole/oxazole-forming peptide maturase, SagC family component; Region: cyclo_dehy_ocin; TIGR03603 1134454000515 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 1134454000516 putative FMN binding site [chemical binding]; other site 1134454000517 NADPH bind site [chemical binding]; other site 1134454000518 EXLDI protein; Region: EXLDI; TIGR04342 1134454000519 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1134454000520 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1134454000521 Walker A/P-loop; other site 1134454000522 ATP binding site [chemical binding]; other site 1134454000523 Q-loop/lid; other site 1134454000524 ABC transporter signature motif; other site 1134454000525 Walker B; other site 1134454000526 D-loop; other site 1134454000527 H-loop/switch region; other site 1134454000528 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1134454000529 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1134454000530 Abi-like protein; Region: Abi_2; pfam07751 1134454000531 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1134454000532 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 1134454000533 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 1134454000534 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1134454000535 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1134454000536 Walker A/P-loop; other site 1134454000537 ATP binding site [chemical binding]; other site 1134454000538 Q-loop/lid; other site 1134454000539 ABC transporter signature motif; other site 1134454000540 Walker B; other site 1134454000541 D-loop; other site 1134454000542 H-loop/switch region; other site 1134454000543 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1134454000544 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 1134454000545 Walker A/P-loop; other site 1134454000546 ATP binding site [chemical binding]; other site 1134454000547 Q-loop/lid; other site 1134454000548 ABC transporter signature motif; other site 1134454000549 Walker B; other site 1134454000550 D-loop; other site 1134454000551 H-loop/switch region; other site 1134454000552 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1134454000553 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1134454000554 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 1134454000555 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565 1134454000556 Dihydroorotate dehydrogenase (DHOD) like proteins. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_like; cd04739 1134454000557 putative active site [active] 1134454000558 putative FMN binding site [chemical binding]; other site 1134454000559 putative substrate binding site [chemical binding]; other site 1134454000560 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 1134454000561 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1134454000562 dimer interface [polypeptide binding]; other site 1134454000563 PYR/PP interface [polypeptide binding]; other site 1134454000564 TPP binding site [chemical binding]; other site 1134454000565 substrate binding site [chemical binding]; other site 1134454000566 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1134454000567 Domain of unknown function; Region: EKR; smart00890 1134454000568 4Fe-4S binding domain; Region: Fer4_6; pfam12837 1134454000569 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1134454000570 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 1134454000571 TPP-binding site [chemical binding]; other site 1134454000572 dimer interface [polypeptide binding]; other site 1134454000573 putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771 1134454000574 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1134454000575 4Fe-4S binding domain; Region: Fer4; pfam00037 1134454000576 Domain of unknown function DUF77; Region: DUF77; pfam01910 1134454000577 L-lactate permease; Region: Lactate_perm; cl00701 1134454000578 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 1134454000579 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1134454000580 Cysteine-rich domain; Region: CCG; pfam02754 1134454000581 Cysteine-rich domain; Region: CCG; pfam02754 1134454000582 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 1134454000583 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1134454000584 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1134454000585 Uncharacterized conserved protein [Function unknown]; Region: COG1556 1134454000586 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1134454000587 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1134454000588 Walker A/P-loop; other site 1134454000589 ATP binding site [chemical binding]; other site 1134454000590 Q-loop/lid; other site 1134454000591 ABC transporter signature motif; other site 1134454000592 Walker B; other site 1134454000593 D-loop; other site 1134454000594 H-loop/switch region; other site 1134454000595 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 1134454000596 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1134454000597 Walker A/P-loop; other site 1134454000598 ATP binding site [chemical binding]; other site 1134454000599 Q-loop/lid; other site 1134454000600 ABC transporter signature motif; other site 1134454000601 Walker B; other site 1134454000602 D-loop; other site 1134454000603 H-loop/switch region; other site 1134454000604 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1134454000605 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 1134454000606 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1134454000607 Walker A/P-loop; other site 1134454000608 ATP binding site [chemical binding]; other site 1134454000609 Q-loop/lid; other site 1134454000610 ABC transporter signature motif; other site 1134454000611 Walker B; other site 1134454000612 D-loop; other site 1134454000613 H-loop/switch region; other site 1134454000614 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1134454000615 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1134454000616 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1134454000617 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1134454000618 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1134454000619 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1134454000620 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1134454000621 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1134454000622 Walker A/P-loop; other site 1134454000623 ATP binding site [chemical binding]; other site 1134454000624 Q-loop/lid; other site 1134454000625 ABC transporter signature motif; other site 1134454000626 Walker B; other site 1134454000627 D-loop; other site 1134454000628 H-loop/switch region; other site 1134454000629 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1134454000630 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1134454000631 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1134454000632 Walker A/P-loop; other site 1134454000633 ATP binding site [chemical binding]; other site 1134454000634 Q-loop/lid; other site 1134454000635 ABC transporter signature motif; other site 1134454000636 Walker B; other site 1134454000637 D-loop; other site 1134454000638 H-loop/switch region; other site 1134454000639 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1134454000640 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1134454000641 non-specific DNA binding site [nucleotide binding]; other site 1134454000642 salt bridge; other site 1134454000643 sequence-specific DNA binding site [nucleotide binding]; other site 1134454000644 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1134454000645 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1134454000646 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1134454000647 dimer interface [polypeptide binding]; other site 1134454000648 putative anticodon binding site; other site 1134454000649 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1134454000650 motif 1; other site 1134454000651 dimer interface [polypeptide binding]; other site 1134454000652 active site 1134454000653 motif 2; other site 1134454000654 motif 3; other site 1134454000655 Uncharacterized protein family (UPF0233); Region: UPF0233; pfam06781 1134454000656 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1134454000657 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1134454000658 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1134454000659 active site 1134454000660 ATP binding site [chemical binding]; other site 1134454000661 substrate binding site [chemical binding]; other site 1134454000662 activation loop (A-loop); other site 1134454000663 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1134454000664 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1134454000665 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1134454000666 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1134454000667 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 1134454000668 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1134454000669 active site 1134454000670 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1134454000671 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1134454000672 phosphopeptide binding site; other site 1134454000673 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 1134454000674 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1134454000675 phosphopeptide binding site; other site 1134454000676 Phosphotransferase enzyme family; Region: APH; pfam01636 1134454000677 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1134454000678 active site 1134454000679 ATP binding site [chemical binding]; other site 1134454000680 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1134454000681 RHS Repeat; Region: RHS_repeat; cl11982 1134454000682 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 1134454000683 RHS Repeat; Region: RHS_repeat; cl11982 1134454000684 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1134454000685 RHS Repeat; Region: RHS_repeat; pfam05593 1134454000686 RHS Repeat; Region: RHS_repeat; pfam05593 1134454000687 RHS Repeat; Region: RHS_repeat; pfam05593 1134454000688 RHS Repeat; Region: RHS_repeat; pfam05593 1134454000689 RHS Repeat; Region: RHS_repeat; cl11982 1134454000690 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1134454000691 RHS Repeat; Region: RHS_repeat; cl11982 1134454000692 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1134454000693 RHS Repeat; Region: RHS_repeat; pfam05593 1134454000694 RHS Repeat; Region: RHS_repeat; pfam05593 1134454000695 RHS Repeat; Region: RHS_repeat; pfam05593 1134454000696 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 1134454000697 RHS Repeat; Region: RHS_repeat; pfam05593 1134454000698 RHS Repeat; Region: RHS_repeat; pfam05593 1134454000699 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1134454000700 RNA binding surface [nucleotide binding]; other site 1134454000701 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 1134454000702 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1134454000703 Walker A motif; other site 1134454000704 ATP binding site [chemical binding]; other site 1134454000705 Walker B motif; other site 1134454000706 arginine finger; other site 1134454000707 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1134454000708 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG0718 1134454000709 recombination protein RecR; Reviewed; Region: recR; PRK00076 1134454000710 RecR protein; Region: RecR; pfam02132 1134454000711 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1134454000712 putative active site [active] 1134454000713 putative metal-binding site [ion binding]; other site 1134454000714 tetramer interface [polypeptide binding]; other site 1134454000715 Predicted transcriptional regulators [Transcription]; Region: COG1695 1134454000716 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1134454000717 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1134454000718 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1134454000719 Walker A/P-loop; other site 1134454000720 ATP binding site [chemical binding]; other site 1134454000721 Q-loop/lid; other site 1134454000722 ABC transporter signature motif; other site 1134454000723 Walker B; other site 1134454000724 D-loop; other site 1134454000725 H-loop/switch region; other site 1134454000726 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1134454000727 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1134454000728 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1134454000729 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 1134454000730 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1134454000731 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1134454000732 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1134454000733 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1134454000734 active site 1134454000735 motif I; other site 1134454000736 motif II; other site 1134454000737 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1134454000738 Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060 1134454000739 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1134454000740 active site 1134454000741 HIGH motif; other site 1134454000742 nucleotide binding site [chemical binding]; other site 1134454000743 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1134454000744 active site 1134454000745 KMSKS motif; other site 1134454000746 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 1134454000747 tRNA binding surface [nucleotide binding]; other site 1134454000748 anticodon binding site; other site 1134454000749 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 1134454000750 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1134454000751 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 1134454000752 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1134454000753 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1134454000754 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1134454000755 Transcription factor WhiB; Region: Whib; pfam02467 1134454000756 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 1134454000757 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 1134454000758 homotrimer interaction site [polypeptide binding]; other site 1134454000759 putative active site [active] 1134454000760 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1134454000761 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1134454000762 ligand binding site [chemical binding]; other site 1134454000763 flexible hinge region; other site 1134454000764 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1134454000765 putative switch regulator; other site 1134454000766 non-specific DNA interactions [nucleotide binding]; other site 1134454000767 DNA binding site [nucleotide binding] 1134454000768 sequence specific DNA binding site [nucleotide binding]; other site 1134454000769 putative cAMP binding site [chemical binding]; other site 1134454000770 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1134454000771 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1134454000772 minor groove reading motif; other site 1134454000773 helix-hairpin-helix signature motif; other site 1134454000774 substrate binding pocket [chemical binding]; other site 1134454000775 active site 1134454000776 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1134454000777 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1134454000778 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1134454000779 catalytic residues [active] 1134454000780 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1134454000781 putative active site [active] 1134454000782 putative CoA binding site [chemical binding]; other site 1134454000783 nudix motif; other site 1134454000784 metal binding site [ion binding]; metal-binding site 1134454000785 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 1134454000786 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1134454000787 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 1134454000788 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 1134454000789 helicase/secretion neighborhood ATPase; Region: heli_sec_ATPase; TIGR03819 1134454000790 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 1134454000791 Walker A motif; other site 1134454000792 ATP binding site [chemical binding]; other site 1134454000793 Walker B motif; other site 1134454000794 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1134454000795 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 1134454000796 helicase/secretion neighborhood TadE-like protein; Region: tadE_like_DECH; TIGR03816 1134454000797 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 1134454000798 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1134454000799 ATP binding site [chemical binding]; other site 1134454000800 putative Mg++ binding site [ion binding]; other site 1134454000801 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1134454000802 nucleotide binding region [chemical binding]; other site 1134454000803 ATP-binding site [chemical binding]; other site 1134454000804 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1134454000805 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 1134454000806 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1134454000807 S-adenosylmethionine binding site [chemical binding]; other site 1134454000808 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 1134454000809 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1134454000810 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1134454000811 active site 1134454000812 interdomain interaction site; other site 1134454000813 putative metal-binding site [ion binding]; other site 1134454000814 nucleotide binding site [chemical binding]; other site 1134454000815 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1134454000816 domain I; other site 1134454000817 DNA binding groove [nucleotide binding] 1134454000818 phosphate binding site [ion binding]; other site 1134454000819 domain II; other site 1134454000820 domain III; other site 1134454000821 nucleotide binding site [chemical binding]; other site 1134454000822 catalytic site [active] 1134454000823 domain IV; other site 1134454000824 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1134454000825 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1134454000826 thymidylate kinase; Validated; Region: tmk; PRK00698 1134454000827 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1134454000828 TMP-binding site; other site 1134454000829 ATP-binding site [chemical binding]; other site 1134454000830 DNA polymerase III subunit delta'; Validated; Region: PRK07940 1134454000831 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1134454000832 Walker A motif; other site 1134454000833 ATP binding site [chemical binding]; other site 1134454000834 Walker B motif; other site 1134454000835 arginine finger; other site 1134454000836 Predicted membrane protein [Function unknown]; Region: COG2259 1134454000837 PSP1 C-terminal conserved region; Region: PSP1; cl00770 1134454000838 TAP-like protein; Region: Abhydrolase_4; pfam08386 1134454000839 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 1134454000840 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 1134454000841 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1134454000842 catalytic core [active] 1134454000843 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 1134454000844 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1134454000845 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1134454000846 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1134454000847 dimer interface [polypeptide binding]; other site 1134454000848 substrate binding site [chemical binding]; other site 1134454000849 metal binding sites [ion binding]; metal-binding site 1134454000850 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 1134454000851 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1134454000852 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 1134454000853 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1134454000854 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1134454000855 Ligand Binding Site [chemical binding]; other site 1134454000856 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1134454000857 active site 1134454000858 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1134454000859 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1134454000860 Walker A motif; other site 1134454000861 ATP binding site [chemical binding]; other site 1134454000862 Walker B motif; other site 1134454000863 arginine finger; other site 1134454000864 Peptidase family M41; Region: Peptidase_M41; pfam01434 1134454000865 Protein of unknown function (DUF3729); Region: DUF3729; pfam12526 1134454000866 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1134454000867 homodecamer interface [polypeptide binding]; other site 1134454000868 GTP cyclohydrolase I; Provisional; Region: PLN03044 1134454000869 active site 1134454000870 putative catalytic site residues [active] 1134454000871 zinc binding site [ion binding]; other site 1134454000872 GTP-CH-I/GFRP interaction surface; other site 1134454000873 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1134454000874 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1134454000875 ligand binding site [chemical binding]; other site 1134454000876 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1134454000877 dihydropteroate synthase; Region: DHPS; TIGR01496 1134454000878 substrate binding pocket [chemical binding]; other site 1134454000879 dimer interface [polypeptide binding]; other site 1134454000880 inhibitor binding site; inhibition site 1134454000881 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1134454000882 homooctamer interface [polypeptide binding]; other site 1134454000883 active site 1134454000884 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1134454000885 catalytic center binding site [active] 1134454000886 ATP binding site [chemical binding]; other site 1134454000887 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1134454000888 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 1134454000889 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 1134454000890 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 1134454000891 Lsr2; Region: Lsr2; pfam11774 1134454000892 Clp protease ATP binding subunit; Region: clpC; CHL00095 1134454000893 Clp amino terminal domain; Region: Clp_N; pfam02861 1134454000894 Clp amino terminal domain; Region: Clp_N; pfam02861 1134454000895 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1134454000896 Walker A motif; other site 1134454000897 ATP binding site [chemical binding]; other site 1134454000898 Walker B motif; other site 1134454000899 arginine finger; other site 1134454000900 UvrB/uvrC motif; Region: UVR; pfam02151 1134454000901 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1134454000902 Walker A motif; other site 1134454000903 ATP binding site [chemical binding]; other site 1134454000904 Walker B motif; other site 1134454000905 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1134454000906 Protein of unknown function (DUF2891); Region: DUF2891; pfam11199 1134454000907 Predicted membrane protein [Function unknown]; Region: COG3817 1134454000908 Protein of unknown function (DUF979); Region: DUF979; pfam06166 1134454000909 Protein of unknown function (DUF969); Region: DUF969; pfam06149 1134454000910 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 1134454000911 putative active site [active] 1134454000912 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 1134454000913 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 1134454000914 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 1134454000915 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1134454000916 putative substrate translocation pore; other site 1134454000917 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1134454000918 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 1134454000919 TIGR01777 family protein; Region: yfcH 1134454000920 putative NAD(P) binding site [chemical binding]; other site 1134454000921 putative active site [active] 1134454000922 Rhomboid family; Region: Rhomboid; pfam01694 1134454000923 hypothetical protein; Provisional; Region: PRK06547 1134454000924 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1134454000925 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1134454000926 active site 1134454000927 phosphorylation site [posttranslational modification] 1134454000928 intermolecular recognition site; other site 1134454000929 dimerization interface [polypeptide binding]; other site 1134454000930 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1134454000931 DNA binding residues [nucleotide binding] 1134454000932 dimerization interface [polypeptide binding]; other site 1134454000933 Histidine kinase; Region: HisKA_3; pfam07730 1134454000934 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1134454000935 ATP binding site [chemical binding]; other site 1134454000936 Mg2+ binding site [ion binding]; other site 1134454000937 G-X-G motif; other site 1134454000938 CAT RNA binding domain; Region: CAT_RBD; smart01061 1134454000939 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1134454000940 PRD domain; Region: PRD; pfam00874 1134454000941 PRD domain; Region: PRD; pfam00874 1134454000942 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1134454000943 HPr interaction site; other site 1134454000944 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1134454000945 active site 1134454000946 phosphorylation site [posttranslational modification] 1134454000947 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 1134454000948 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1134454000949 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1134454000950 active site turn [active] 1134454000951 phosphorylation site [posttranslational modification] 1134454000952 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1134454000953 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1134454000954 endonuclease III; Region: ENDO3c; smart00478 1134454000955 minor groove reading motif; other site 1134454000956 helix-hairpin-helix signature motif; other site 1134454000957 active site 1134454000958 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1134454000959 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1134454000960 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1134454000961 inhibitor-cofactor binding pocket; inhibition site 1134454000962 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1134454000963 catalytic residue [active] 1134454000964 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1134454000965 dimer interface [polypeptide binding]; other site 1134454000966 active site 1134454000967 Schiff base residues; other site 1134454000968 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 1134454000969 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1134454000970 active site 1134454000971 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1134454000972 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 1134454000973 domain interfaces; other site 1134454000974 active site 1134454000975 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1134454000976 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1134454000977 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1134454000978 Glutamyl-tRNAGlu reductase, N-terminal domain; Region: GlutR_N; pfam05201 1134454000979 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1134454000980 ferrochelatase; Reviewed; Region: hemH; PRK00035 1134454000981 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1134454000982 C-terminal domain interface [polypeptide binding]; other site 1134454000983 active site 1134454000984 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1134454000985 active site 1134454000986 N-terminal domain interface [polypeptide binding]; other site 1134454000987 Chlorite dismutase; Region: Chlor_dismutase; pfam06778 1134454000988 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 1134454000989 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1134454000990 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 1134454000991 DNA repair protein RadA; Provisional; Region: PRK11823 1134454000992 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1134454000993 Walker A motif; other site 1134454000994 ATP binding site [chemical binding]; other site 1134454000995 Walker B motif; other site 1134454000996 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1134454000997 malate dehydrogenase; Provisional; Region: PRK13529 1134454000998 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1134454000999 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1134454001000 NAD(P) binding site [chemical binding]; other site 1134454001001 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 1134454001002 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1134454001003 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1134454001004 AP (apurinic/apyrimidinic) site pocket; other site 1134454001005 DNA interaction; other site 1134454001006 Metal-binding active site; metal-binding site 1134454001007 Proline dehydrogenase; Region: Pro_dh; cl03282 1134454001008 CAAX protease self-immunity; Region: Abi; pfam02517 1134454001009 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1134454001010 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1134454001011 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1134454001012 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1134454001013 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 1134454001014 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 1134454001015 active site 1134454001016 homodimer interface [polypeptide binding]; other site 1134454001017 SAM binding site [chemical binding]; other site 1134454001018 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1134454001019 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1134454001020 active site 1134454001021 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1134454001022 catalytic core [active] 1134454001023 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1134454001024 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1134454001025 catalytic residues [active] 1134454001026 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1134454001027 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1134454001028 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 1134454001029 ResB-like family; Region: ResB; pfam05140 1134454001030 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 1134454001031 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 1134454001032 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1134454001033 DNA binding residues [nucleotide binding] 1134454001034 Sporulation and spore germination; Region: Germane; pfam10646 1134454001035 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1134454001036 classical (c) SDRs; Region: SDR_c; cd05233 1134454001037 NAD(P) binding site [chemical binding]; other site 1134454001038 active site 1134454001039 mycothione reductase; Reviewed; Region: PRK07846 1134454001040 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1134454001041 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1134454001042 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1134454001043 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1134454001044 intersubunit interface [polypeptide binding]; other site 1134454001045 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1134454001046 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1134454001047 Walker A/P-loop; other site 1134454001048 ATP binding site [chemical binding]; other site 1134454001049 Q-loop/lid; other site 1134454001050 ABC transporter signature motif; other site 1134454001051 Walker B; other site 1134454001052 D-loop; other site 1134454001053 H-loop/switch region; other site 1134454001054 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1134454001055 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1134454001056 ABC-ATPase subunit interface; other site 1134454001057 dimer interface [polypeptide binding]; other site 1134454001058 putative PBP binding regions; other site 1134454001059 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1134454001060 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1134454001061 FAD binding pocket [chemical binding]; other site 1134454001062 FAD binding motif [chemical binding]; other site 1134454001063 phosphate binding motif [ion binding]; other site 1134454001064 NAD binding pocket [chemical binding]; other site 1134454001065 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 1134454001066 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1134454001067 Walker A/P-loop; other site 1134454001068 ATP binding site [chemical binding]; other site 1134454001069 Q-loop/lid; other site 1134454001070 ABC transporter signature motif; other site 1134454001071 Walker B; other site 1134454001072 D-loop; other site 1134454001073 H-loop/switch region; other site 1134454001074 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1134454001075 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1134454001076 dimer interface [polypeptide binding]; other site 1134454001077 conserved gate region; other site 1134454001078 putative PBP binding loops; other site 1134454001079 ABC-ATPase subunit interface; other site 1134454001080 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 1134454001081 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1134454001082 dimer interface [polypeptide binding]; other site 1134454001083 conserved gate region; other site 1134454001084 putative PBP binding loops; other site 1134454001085 ABC-ATPase subunit interface; other site 1134454001086 PBP superfamily domain; Region: PBP_like_2; cl17296 1134454001087 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1134454001088 active site 1134454001089 Ap6A binding site [chemical binding]; other site 1134454001090 nudix motif; other site 1134454001091 metal binding site [ion binding]; metal-binding site 1134454001092 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1134454001093 catalytic core [active] 1134454001094 polyphosphate kinase; Provisional; Region: PRK05443 1134454001095 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1134454001096 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1134454001097 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 1134454001098 putative domain interface [polypeptide binding]; other site 1134454001099 putative active site [active] 1134454001100 catalytic site [active] 1134454001101 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 1134454001102 putative domain interface [polypeptide binding]; other site 1134454001103 putative active site [active] 1134454001104 catalytic site [active] 1134454001105 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1134454001106 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1134454001107 DNA binding site [nucleotide binding] 1134454001108 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1134454001109 putative active site [active] 1134454001110 dimerization interface [polypeptide binding]; other site 1134454001111 putative tRNAtyr binding site [nucleotide binding]; other site 1134454001112 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 1134454001113 heme-binding site [chemical binding]; other site 1134454001114 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 1134454001115 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1134454001116 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1134454001117 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1134454001118 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1134454001119 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1134454001120 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1134454001121 NAD(P) binding site [chemical binding]; other site 1134454001122 active site 1134454001123 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1134454001124 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1134454001125 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1134454001126 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1134454001127 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1134454001128 dimerization domain swap beta strand [polypeptide binding]; other site 1134454001129 regulatory protein interface [polypeptide binding]; other site 1134454001130 active site 1134454001131 regulatory phosphorylation site [posttranslational modification]; other site 1134454001132 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1134454001133 substrate binding site; other site 1134454001134 dimer interface; other site 1134454001135 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1134454001136 homotrimer interaction site [polypeptide binding]; other site 1134454001137 zinc binding site [ion binding]; other site 1134454001138 CDP-binding sites; other site 1134454001139 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829 1134454001140 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 1134454001141 active site 1134454001142 P-loop; other site 1134454001143 phosphorylation site [posttranslational modification] 1134454001144 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 1134454001145 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1134454001146 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1134454001147 active site 1134454001148 phosphorylation site [posttranslational modification] 1134454001149 intermolecular recognition site; other site 1134454001150 dimerization interface [polypeptide binding]; other site 1134454001151 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1134454001152 DNA binding site [nucleotide binding] 1134454001153 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1134454001154 dimer interface [polypeptide binding]; other site 1134454001155 phosphorylation site [posttranslational modification] 1134454001156 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1134454001157 ATP binding site [chemical binding]; other site 1134454001158 Mg2+ binding site [ion binding]; other site 1134454001159 G-X-G motif; other site 1134454001160 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1134454001161 PhoU domain; Region: PhoU; pfam01895 1134454001162 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1134454001163 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 1134454001164 NodB motif; other site 1134454001165 active site 1134454001166 catalytic site [active] 1134454001167 Zn binding site [ion binding]; other site 1134454001168 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1134454001169 catalytic core [active] 1134454001170 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 1134454001171 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1134454001172 active site 1134454001173 phosphorylation site [posttranslational modification] 1134454001174 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 1134454001175 active site 1134454001176 P-loop; other site 1134454001177 phosphorylation site [posttranslational modification] 1134454001178 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 1134454001179 active site 1134454001180 homodimer interface [polypeptide binding]; other site 1134454001181 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1134454001182 serine hydroxymethyltransferase; Provisional; Region: PRK13580 1134454001183 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1134454001184 dimer interface [polypeptide binding]; other site 1134454001185 active site 1134454001186 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1134454001187 folate binding site [chemical binding]; other site 1134454001188 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1134454001189 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1134454001190 substrate binding site [chemical binding]; other site 1134454001191 ATP binding site [chemical binding]; other site 1134454001192 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 1134454001193 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1134454001194 active site 1134454001195 intersubunit interface [polypeptide binding]; other site 1134454001196 catalytic residue [active] 1134454001197 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 1134454001198 substrate binding site [chemical binding]; other site 1134454001199 catalytic residues [active] 1134454001200 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1134454001201 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1134454001202 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1134454001203 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1134454001204 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1134454001205 active site 1134454001206 HIGH motif; other site 1134454001207 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1134454001208 KMSKS motif; other site 1134454001209 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1134454001210 tRNA binding surface [nucleotide binding]; other site 1134454001211 anticodon binding site; other site 1134454001212 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 1134454001213 Asp23 family; Region: Asp23; pfam03780 1134454001214 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 1134454001215 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1134454001216 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1134454001217 DNA binding residues [nucleotide binding] 1134454001218 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1134454001219 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1134454001220 Walker A/P-loop; other site 1134454001221 ATP binding site [chemical binding]; other site 1134454001222 Q-loop/lid; other site 1134454001223 ABC transporter signature motif; other site 1134454001224 Walker B; other site 1134454001225 D-loop; other site 1134454001226 H-loop/switch region; other site 1134454001227 TOBE domain; Region: TOBE_2; pfam08402 1134454001228 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1134454001229 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1134454001230 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1134454001231 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1134454001232 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1134454001233 putative DNA binding site [nucleotide binding]; other site 1134454001234 putative Zn2+ binding site [ion binding]; other site 1134454001235 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1134454001236 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1134454001237 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1134454001238 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1134454001239 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1134454001240 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1134454001241 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1134454001242 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1134454001243 dimer interface [polypeptide binding]; other site 1134454001244 conserved gate region; other site 1134454001245 putative PBP binding loops; other site 1134454001246 ABC-ATPase subunit interface; other site 1134454001247 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1134454001248 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1134454001249 dimer interface [polypeptide binding]; other site 1134454001250 conserved gate region; other site 1134454001251 ABC-ATPase subunit interface; other site 1134454001252 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 1134454001253 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1134454001254 NAD(P) binding site [chemical binding]; other site 1134454001255 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1134454001256 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1134454001257 substrate-cofactor binding pocket; other site 1134454001258 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1134454001259 catalytic residue [active] 1134454001260 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1134454001261 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 1134454001262 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1134454001263 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1134454001264 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1134454001265 Walker A/P-loop; other site 1134454001266 ATP binding site [chemical binding]; other site 1134454001267 Q-loop/lid; other site 1134454001268 ABC transporter signature motif; other site 1134454001269 Walker B; other site 1134454001270 D-loop; other site 1134454001271 H-loop/switch region; other site 1134454001272 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1134454001273 Protein of unknown function, DUF488; Region: DUF488; cl01246 1134454001274 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 1134454001275 putative ADP-ribose binding site [chemical binding]; other site 1134454001276 putative active site [active] 1134454001277 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1134454001278 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1134454001279 NAD(P) binding site [chemical binding]; other site 1134454001280 substrate binding site [chemical binding]; other site 1134454001281 dimer interface [polypeptide binding]; other site 1134454001282 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1134454001283 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1134454001284 Walker A/P-loop; other site 1134454001285 ATP binding site [chemical binding]; other site 1134454001286 Q-loop/lid; other site 1134454001287 ABC transporter signature motif; other site 1134454001288 Walker B; other site 1134454001289 D-loop; other site 1134454001290 H-loop/switch region; other site 1134454001291 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1134454001292 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1134454001293 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1134454001294 active site 1134454001295 phosphorylation site [posttranslational modification] 1134454001296 intermolecular recognition site; other site 1134454001297 dimerization interface [polypeptide binding]; other site 1134454001298 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1134454001299 DNA binding residues [nucleotide binding] 1134454001300 dimerization interface [polypeptide binding]; other site 1134454001301 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1134454001302 catalytic core [active] 1134454001303 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 1134454001304 cobyric acid synthase; Provisional; Region: PRK00784 1134454001305 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1134454001306 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1134454001307 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1134454001308 catalytic triad [active] 1134454001309 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 1134454001310 active site 1134454001311 SAM binding site [chemical binding]; other site 1134454001312 homodimer interface [polypeptide binding]; other site 1134454001313 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 1134454001314 active site 1134454001315 SAM binding site [chemical binding]; other site 1134454001316 homodimer interface [polypeptide binding]; other site 1134454001317 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 1134454001318 putative homodimer interface [polypeptide binding]; other site 1134454001319 active site 1134454001320 SAM binding site [chemical binding]; other site 1134454001321 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 1134454001322 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 1134454001323 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 1134454001324 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 1134454001325 active site 1134454001326 SAM binding site [chemical binding]; other site 1134454001327 homodimer interface [polypeptide binding]; other site 1134454001328 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1134454001329 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1134454001330 putative active site [active] 1134454001331 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 1134454001332 putative active site [active] 1134454001333 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 1134454001334 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1134454001335 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1134454001336 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1134454001337 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1134454001338 putative PBP binding regions; other site 1134454001339 ABC-ATPase subunit interface; other site 1134454001340 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1134454001341 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1134454001342 Walker A/P-loop; other site 1134454001343 ATP binding site [chemical binding]; other site 1134454001344 Q-loop/lid; other site 1134454001345 ABC transporter signature motif; other site 1134454001346 Walker B; other site 1134454001347 D-loop; other site 1134454001348 H-loop/switch region; other site 1134454001349 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1134454001350 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 1134454001351 putative ligand binding residues [chemical binding]; other site 1134454001352 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 1134454001353 AAA domain; Region: AAA_14; pfam13173 1134454001354 Nuclease-related domain; Region: NERD; pfam08378 1134454001355 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 1134454001356 Precorrin-8X methylmutase; Region: CbiC; pfam02570 1134454001357 cobalt transport protein CbiM; Validated; Region: PRK08319 1134454001358 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 1134454001359 cobalt transport protein CbiN; Provisional; Region: PRK02898 1134454001360 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 1134454001361 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1134454001362 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 1134454001363 Walker A/P-loop; other site 1134454001364 ATP binding site [chemical binding]; other site 1134454001365 Q-loop/lid; other site 1134454001366 ABC transporter signature motif; other site 1134454001367 Walker B; other site 1134454001368 D-loop; other site 1134454001369 H-loop/switch region; other site 1134454001370 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 1134454001371 Methyltransferase domain; Region: Methyltransf_18; pfam12847 1134454001372 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 1134454001373 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 1134454001374 homodimer interface [polypeptide binding]; other site 1134454001375 Walker A motif; other site 1134454001376 ATP binding site [chemical binding]; other site 1134454001377 hydroxycobalamin binding site [chemical binding]; other site 1134454001378 Walker B motif; other site 1134454001379 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 1134454001380 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 1134454001381 catalytic triad [active] 1134454001382 hypothetical protein; Provisional; Region: PRK07908 1134454001383 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1134454001384 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1134454001385 homodimer interface [polypeptide binding]; other site 1134454001386 catalytic residue [active] 1134454001387 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1134454001388 homodimer interface [polypeptide binding]; other site 1134454001389 active site 1134454001390 SAM binding site [chemical binding]; other site 1134454001391 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 1134454001392 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 1134454001393 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 1134454001394 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1134454001395 putative dimer interface [polypeptide binding]; other site 1134454001396 active site pocket [active] 1134454001397 putative cataytic base [active] 1134454001398 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 1134454001399 homotrimer interface [polypeptide binding]; other site 1134454001400 Walker A motif; other site 1134454001401 GTP binding site [chemical binding]; other site 1134454001402 Walker B motif; other site 1134454001403 cobalamin synthase; Reviewed; Region: cobS; PRK00235 1134454001404 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1134454001405 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1134454001406 intersubunit interface [polypeptide binding]; other site 1134454001407 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 1134454001408 S-Ribosylhomocysteinase (LuxS); Region: LuxS; cl00802 1134454001409 S-ribosylhomocysteinase; Provisional; Region: PRK02260 1134454001410 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 1134454001411 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1134454001412 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1134454001413 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 1134454001414 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1134454001415 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1134454001416 ring oligomerisation interface [polypeptide binding]; other site 1134454001417 ATP/Mg binding site [chemical binding]; other site 1134454001418 stacking interactions; other site 1134454001419 hinge regions; other site 1134454001420 Transaldolase; Region: Transaldolase; pfam00923 1134454001421 catalytic residue [active] 1134454001422 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1134454001423 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1134454001424 DNA-binding site [nucleotide binding]; DNA binding site 1134454001425 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1134454001426 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1134454001427 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1134454001428 substrate binding site [chemical binding]; other site 1134454001429 ATP binding site [chemical binding]; other site 1134454001430 KduI/IolB family; Region: KduI; pfam04962 1134454001431 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 1134454001432 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1134454001433 PYR/PP interface [polypeptide binding]; other site 1134454001434 dimer interface [polypeptide binding]; other site 1134454001435 TPP binding site [chemical binding]; other site 1134454001436 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cd00368 1134454001437 molybdopterin cofactor binding site; other site 1134454001438 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 1134454001439 TPP-binding site; other site 1134454001440 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1134454001441 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1134454001442 tetrameric interface [polypeptide binding]; other site 1134454001443 NAD binding site [chemical binding]; other site 1134454001444 catalytic residues [active] 1134454001445 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1134454001446 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1134454001447 DNA binding site [nucleotide binding] 1134454001448 domain linker motif; other site 1134454001449 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1134454001450 dimerization interface [polypeptide binding]; other site 1134454001451 ligand binding site [chemical binding]; other site 1134454001452 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1134454001453 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1134454001454 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1134454001455 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1134454001456 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1134454001457 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1134454001458 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1134454001459 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 1134454001460 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1134454001461 putative substrate translocation pore; other site 1134454001462 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1134454001463 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1134454001464 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1134454001465 DNA interaction; other site 1134454001466 Metal-binding active site; metal-binding site 1134454001467 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1134454001468 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1134454001469 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1134454001470 CAAX protease self-immunity; Region: Abi; pfam02517 1134454001471 CutC family; Region: CutC; cl01218 1134454001472 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1134454001473 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1134454001474 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1134454001475 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1134454001476 ATP binding site [chemical binding]; other site 1134454001477 putative Mg++ binding site [ion binding]; other site 1134454001478 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1134454001479 nucleotide binding region [chemical binding]; other site 1134454001480 ATP-binding site [chemical binding]; other site 1134454001481 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1134454001482 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1134454001483 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1134454001484 active site 1134454001485 trimer interface [polypeptide binding]; other site 1134454001486 allosteric site; other site 1134454001487 active site lid [active] 1134454001488 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1134454001489 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1134454001490 DNA-binding site [nucleotide binding]; DNA binding site 1134454001491 RNA-binding motif; other site 1134454001492 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 1134454001493 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1134454001494 phosphoserine aminotransferase; Provisional; Region: PRK03080 1134454001495 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1134454001496 catalytic residue [active] 1134454001497 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1134454001498 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1134454001499 active site 1134454001500 dimer interface [polypeptide binding]; other site 1134454001501 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1134454001502 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 1134454001503 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1134454001504 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1134454001505 catalytic residues [active] 1134454001506 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1134454001507 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1134454001508 putative substrate translocation pore; other site 1134454001509 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1134454001510 Eukaryotic UGPase catalyses the synthesis of UDP-Glucose; Region: UGPase_euk; cd00897 1134454001511 active site 1134454001512 substrate binding site; other site 1134454001513 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 1134454001514 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1134454001515 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1134454001516 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 1134454001517 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1134454001518 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 1134454001519 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1134454001520 dimer interface [polypeptide binding]; other site 1134454001521 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1134454001522 putative MPT binding site; other site 1134454001523 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1134454001524 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1134454001525 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 1134454001526 MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor...; Region: MoaC; cl00242 1134454001527 trimer interface [polypeptide binding]; other site 1134454001528 dimer interface [polypeptide binding]; other site 1134454001529 putative active site [active] 1134454001530 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1134454001531 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1134454001532 dimer interface [polypeptide binding]; other site 1134454001533 putative functional site; other site 1134454001534 putative MPT binding site; other site 1134454001535 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1134454001536 MoaE homodimer interface [polypeptide binding]; other site 1134454001537 MoaD interaction [polypeptide binding]; other site 1134454001538 active site residues [active] 1134454001539 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1134454001540 MoaE interaction surface [polypeptide binding]; other site 1134454001541 MoeB interaction surface [polypeptide binding]; other site 1134454001542 thiocarboxylated glycine; other site 1134454001543 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1134454001544 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1134454001545 FeS/SAM binding site; other site 1134454001546 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1134454001547 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 1134454001548 DNA binding residues [nucleotide binding] 1134454001549 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 1134454001550 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 1134454001551 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1134454001552 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1134454001553 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1134454001554 dimer interface [polypeptide binding]; other site 1134454001555 conserved gate region; other site 1134454001556 putative PBP binding loops; other site 1134454001557 ABC-ATPase subunit interface; other site 1134454001558 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 1134454001559 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1134454001560 Walker A/P-loop; other site 1134454001561 ATP binding site [chemical binding]; other site 1134454001562 Q-loop/lid; other site 1134454001563 ABC transporter signature motif; other site 1134454001564 Walker B; other site 1134454001565 D-loop; other site 1134454001566 H-loop/switch region; other site 1134454001567 Predicted transcriptional regulator [Transcription]; Region: COG2345 1134454001568 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 1134454001569 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 1134454001570 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 1134454001571 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1134454001572 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 1134454001573 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1134454001574 [4Fe-4S] binding site [ion binding]; other site 1134454001575 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1134454001576 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1134454001577 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1134454001578 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1134454001579 molybdopterin cofactor binding site; other site 1134454001580 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1134454001581 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1134454001582 putative substrate translocation pore; other site 1134454001583 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1134454001584 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1134454001585 GTP binding site; other site 1134454001586 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1134454001587 MPT binding site; other site 1134454001588 trimer interface [polypeptide binding]; other site 1134454001589 DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519 1134454001590 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 1134454001591 4Fe-4S binding domain; Region: Fer4; pfam00037 1134454001592 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 1134454001593 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 1134454001594 putative [Fe4-S4] binding site [ion binding]; other site 1134454001595 putative molybdopterin cofactor binding site [chemical binding]; other site 1134454001596 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 1134454001597 putative molybdopterin cofactor binding site; other site 1134454001598 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 1134454001599 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1134454001600 ATP binding site [chemical binding]; other site 1134454001601 substrate interface [chemical binding]; other site 1134454001602 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1134454001603 ThiS interaction site; other site 1134454001604 putative active site [active] 1134454001605 tetramer interface [polypeptide binding]; other site 1134454001606 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1134454001607 thiS-thiF/thiG interaction site; other site 1134454001608 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1134454001609 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1134454001610 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 1134454001611 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 1134454001612 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 1134454001613 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1134454001614 Predicted methyltransferases [General function prediction only]; Region: COG0313 1134454001615 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1134454001616 putative SAM binding site [chemical binding]; other site 1134454001617 putative homodimer interface [polypeptide binding]; other site 1134454001618 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1134454001619 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1134454001620 active site 1134454001621 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1134454001622 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 1134454001623 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 1134454001624 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1134454001625 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1134454001626 MarR family; Region: MarR_2; cl17246 1134454001627 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1134454001628 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1134454001629 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14360 1134454001630 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1134454001631 Substrate binding site; other site 1134454001632 Mg++ binding site; other site 1134454001633 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1134454001634 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1134454001635 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 1134454001636 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1134454001637 active site 1134454001638 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1134454001639 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1134454001640 5S rRNA interface [nucleotide binding]; other site 1134454001641 CTC domain interface [polypeptide binding]; other site 1134454001642 L16 interface [polypeptide binding]; other site 1134454001643 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1134454001644 putative active site [active] 1134454001645 catalytic residue [active] 1134454001646 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1134454001647 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1134454001648 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH6; cd08260 1134454001649 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1134454001650 putative NAD(P) binding site [chemical binding]; other site 1134454001651 catalytic Zn binding site [ion binding]; other site 1134454001652 structural Zn binding site [ion binding]; other site 1134454001653 Protease prsW family; Region: PrsW-protease; pfam13367 1134454001654 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1134454001655 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1134454001656 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1134454001657 ATP binding site [chemical binding]; other site 1134454001658 putative Mg++ binding site [ion binding]; other site 1134454001659 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1134454001660 nucleotide binding region [chemical binding]; other site 1134454001661 ATP-binding site [chemical binding]; other site 1134454001662 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1134454001663 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1134454001664 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12333 1134454001665 homodimer interface [polypeptide binding]; other site 1134454001666 metal binding site [ion binding]; metal-binding site 1134454001667 enolase; Provisional; Region: eno; PRK00077 1134454001668 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1134454001669 dimer interface [polypeptide binding]; other site 1134454001670 metal binding site [ion binding]; metal-binding site 1134454001671 substrate binding pocket [chemical binding]; other site 1134454001672 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1134454001673 Septum formation initiator; Region: DivIC; pfam04977 1134454001674 Protein of unknown function (DUF501); Region: DUF501; pfam04417 1134454001675 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1134454001676 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1134454001677 Bax inhibitor 1 like; Region: BaxI_1; cl17691 1134454001678 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 1134454001679 nudix motif; other site 1134454001680 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1134454001681 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1134454001682 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1134454001683 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1134454001684 active site 1134454001685 ATP binding site [chemical binding]; other site 1134454001686 substrate binding site [chemical binding]; other site 1134454001687 activation loop (A-loop); other site 1134454001688 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1134454001689 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1134454001690 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1134454001691 catalytic site [active] 1134454001692 putative active site [active] 1134454001693 putative substrate binding site [chemical binding]; other site 1134454001694 dimer interface [polypeptide binding]; other site 1134454001695 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1134454001696 putative substrate translocation pore; other site 1134454001697 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1134454001698 Protease prsW family; Region: PrsW-protease; pfam13367 1134454001699 Dynamin family; Region: Dynamin_N; pfam00350 1134454001700 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1134454001701 G1 box; other site 1134454001702 GTP/Mg2+ binding site [chemical binding]; other site 1134454001703 G2 box; other site 1134454001704 Switch I region; other site 1134454001705 YfjP GTPase; Region: YfjP; cd11383 1134454001706 G1 box; other site 1134454001707 GTP/Mg2+ binding site [chemical binding]; other site 1134454001708 Switch I region; other site 1134454001709 G2 box; other site 1134454001710 Switch II region; other site 1134454001711 G3 box; other site 1134454001712 G4 box; other site 1134454001713 G5 box; other site 1134454001714 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1134454001715 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1134454001716 dimer interface [polypeptide binding]; other site 1134454001717 ssDNA binding site [nucleotide binding]; other site 1134454001718 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1134454001719 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1134454001720 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1134454001721 Walker A/P-loop; other site 1134454001722 ATP binding site [chemical binding]; other site 1134454001723 Q-loop/lid; other site 1134454001724 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1134454001725 ABC transporter; Region: ABC_tran_2; pfam12848 1134454001726 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1134454001727 Predicted transcriptional regulators [Transcription]; Region: COG1695 1134454001728 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1134454001729 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1134454001730 FAD binding domain; Region: FAD_binding_4; pfam01565 1134454001731 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1134454001732 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1134454001733 MarR family; Region: MarR_2; pfam12802 1134454001734 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1134454001735 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1134454001736 acyl-activating enzyme (AAE) consensus motif; other site 1134454001737 putative AMP binding site [chemical binding]; other site 1134454001738 putative active site [active] 1134454001739 putative CoA binding site [chemical binding]; other site 1134454001740 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1134454001741 active site 1134454001742 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1134454001743 active site 1134454001744 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1134454001745 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1134454001746 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1134454001747 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1134454001748 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1134454001749 nucleotide binding pocket [chemical binding]; other site 1134454001750 K-X-D-G motif; other site 1134454001751 catalytic site [active] 1134454001752 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1134454001753 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1134454001754 Helix-hairpin-helix motif; Region: HHH; pfam00633 1134454001755 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1134454001756 Dimer interface [polypeptide binding]; other site 1134454001757 hypothetical protein; Provisional; Region: PRK01346 1134454001758 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1134454001759 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 1134454001760 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 1134454001761 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1134454001762 putative DNA binding site [nucleotide binding]; other site 1134454001763 catalytic residue [active] 1134454001764 putative H2TH interface [polypeptide binding]; other site 1134454001765 putative catalytic residues [active] 1134454001766 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1134454001767 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1134454001768 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 1134454001769 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1134454001770 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1134454001771 dimer interface [polypeptide binding]; other site 1134454001772 putative anticodon binding site; other site 1134454001773 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1134454001774 motif 1; other site 1134454001775 dimer interface [polypeptide binding]; other site 1134454001776 active site 1134454001777 motif 2; other site 1134454001778 motif 3; other site 1134454001779 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1134454001780 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 1134454001781 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1134454001782 ATP binding site [chemical binding]; other site 1134454001783 putative Mg++ binding site [ion binding]; other site 1134454001784 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1134454001785 ATP-binding site [chemical binding]; other site 1134454001786 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1134454001787 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 1134454001788 trigger factor; Provisional; Region: tig; PRK01490 1134454001789 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1134454001790 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1134454001791 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1134454001792 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1134454001793 Clp protease; Region: CLP_protease; pfam00574 1134454001794 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1134454001795 oligomer interface [polypeptide binding]; other site 1134454001796 active site residues [active] 1134454001797 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 1134454001798 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1134454001799 oligomer interface [polypeptide binding]; other site 1134454001800 active site residues [active] 1134454001801 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1134454001802 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1134454001803 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1134454001804 Walker A motif; other site 1134454001805 ATP binding site [chemical binding]; other site 1134454001806 Walker B motif; other site 1134454001807 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1134454001808 Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown]; Region: COG4946 1134454001809 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1134454001810 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1134454001811 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 1134454001812 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1134454001813 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1134454001814 protein binding site [polypeptide binding]; other site 1134454001815 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 1134454001816 Domain interface; other site 1134454001817 Peptide binding site; other site 1134454001818 Active site tetrad [active] 1134454001819 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208 1134454001820 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1134454001821 active site 1134454001822 HIGH motif; other site 1134454001823 nucleotide binding site [chemical binding]; other site 1134454001824 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1134454001825 active site 1134454001826 KMSKS motif; other site 1134454001827 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1134454001828 tRNA binding surface [nucleotide binding]; other site 1134454001829 anticodon binding site; other site 1134454001830 Thioredoxin; Region: Thioredoxin_4; cl17273 1134454001831 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1134454001832 DoxX; Region: DoxX; pfam07681 1134454001833 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1134454001834 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 1134454001835 putative active site [active] 1134454001836 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 1134454001837 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 1134454001838 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1134454001839 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1134454001840 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1134454001841 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1134454001842 UbiA prenyltransferase family; Region: UbiA; pfam01040 1134454001843 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 1134454001844 catalytic site [active] 1134454001845 BNR repeat-like domain; Region: BNR_2; pfam13088 1134454001846 Asp-box motif; other site 1134454001847 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1134454001848 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1134454001849 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1134454001850 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1134454001851 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1134454001852 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1134454001853 Walker A/P-loop; other site 1134454001854 ATP binding site [chemical binding]; other site 1134454001855 Q-loop/lid; other site 1134454001856 ABC transporter signature motif; other site 1134454001857 Walker B; other site 1134454001858 D-loop; other site 1134454001859 H-loop/switch region; other site 1134454001860 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 1134454001861 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 1134454001862 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1134454001863 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1134454001864 DNA binding site [nucleotide binding] 1134454001865 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_10; cd06292 1134454001866 putative dimerization interface [polypeptide binding]; other site 1134454001867 putative ligand binding site [chemical binding]; other site 1134454001868 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1134454001869 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1134454001870 dimer interface [polypeptide binding]; other site 1134454001871 conserved gate region; other site 1134454001872 putative PBP binding loops; other site 1134454001873 ABC-ATPase subunit interface; other site 1134454001874 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1134454001875 dimer interface [polypeptide binding]; other site 1134454001876 conserved gate region; other site 1134454001877 putative PBP binding loops; other site 1134454001878 ABC-ATPase subunit interface; other site 1134454001879 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 1134454001880 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1134454001881 Predicted transcriptional regulator [Transcription]; Region: COG2345 1134454001882 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1134454001883 dimerization interface [polypeptide binding]; other site 1134454001884 putative DNA binding site [nucleotide binding]; other site 1134454001885 putative Zn2+ binding site [ion binding]; other site 1134454001886 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1134454001887 FeS assembly protein SufB; Region: sufB; TIGR01980 1134454001888 FeS assembly protein SufD; Region: sufD; TIGR01981 1134454001889 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 1134454001890 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 1134454001891 [2Fe-2S] cluster binding site [ion binding]; other site 1134454001892 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1134454001893 FeS assembly ATPase SufC; Region: sufC; TIGR01978 1134454001894 Walker A/P-loop; other site 1134454001895 ATP binding site [chemical binding]; other site 1134454001896 Q-loop/lid; other site 1134454001897 ABC transporter signature motif; other site 1134454001898 Walker B; other site 1134454001899 D-loop; other site 1134454001900 H-loop/switch region; other site 1134454001901 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1134454001902 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1134454001903 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1134454001904 catalytic residue [active] 1134454001905 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1134454001906 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1134454001907 trimerization site [polypeptide binding]; other site 1134454001908 active site 1134454001909 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1134454001910 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1134454001911 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1134454001912 phosphate binding site [ion binding]; other site 1134454001913 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1134454001914 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1134454001915 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1134454001916 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1134454001917 Coenzyme A binding pocket [chemical binding]; other site 1134454001918 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1134454001919 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1134454001920 Walker A/P-loop; other site 1134454001921 ATP binding site [chemical binding]; other site 1134454001922 Q-loop/lid; other site 1134454001923 ABC transporter signature motif; other site 1134454001924 Walker B; other site 1134454001925 D-loop; other site 1134454001926 H-loop/switch region; other site 1134454001927 ABC transporter; Region: ABC_tran_2; pfam12848 1134454001928 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1134454001929 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 1134454001930 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1134454001931 S-adenosylmethionine binding site [chemical binding]; other site 1134454001932 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 1134454001933 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 1134454001934 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1134454001935 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1134454001936 NAD(P) binding site [chemical binding]; other site 1134454001937 active site 1134454001938 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 1134454001939 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1134454001940 NAD(P) binding site [chemical binding]; other site 1134454001941 active site 1134454001942 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1134454001943 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1134454001944 Walker A/P-loop; other site 1134454001945 ATP binding site [chemical binding]; other site 1134454001946 Q-loop/lid; other site 1134454001947 ABC transporter signature motif; other site 1134454001948 Walker B; other site 1134454001949 D-loop; other site 1134454001950 H-loop/switch region; other site 1134454001951 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 1134454001952 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1134454001953 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1134454001954 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1134454001955 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 1134454001956 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1134454001957 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1134454001958 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1134454001959 active site 1134454001960 catalytic residues [active] 1134454001961 metal binding site [ion binding]; metal-binding site 1134454001962 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 1134454001963 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1134454001964 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1134454001965 active site 1134454001966 DNA binding site [nucleotide binding] 1134454001967 Int/Topo IB signature motif; other site 1134454001968 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1134454001969 rRNA interaction site [nucleotide binding]; other site 1134454001970 S8 interaction site; other site 1134454001971 putative laminin-1 binding site; other site 1134454001972 elongation factor Ts; Provisional; Region: tsf; PRK09377 1134454001973 UBA/TS-N domain; Region: UBA; pfam00627 1134454001974 Elongation factor TS; Region: EF_TS; pfam00889 1134454001975 Elongation factor TS; Region: EF_TS; pfam00889 1134454001976 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1134454001977 putative nucleotide binding site [chemical binding]; other site 1134454001978 uridine monophosphate binding site [chemical binding]; other site 1134454001979 homohexameric interface [polypeptide binding]; other site 1134454001980 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1134454001981 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1134454001982 hinge region; other site 1134454001983 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1134454001984 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1134454001985 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 1134454001986 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 1134454001987 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1134454001988 FeS/SAM binding site; other site 1134454001989 glutamate dehydrogenase; Provisional; Region: PRK09414 1134454001990 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1134454001991 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 1134454001992 NAD(P) binding site [chemical binding]; other site 1134454001993 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1134454001994 Beta-lactamase; Region: Beta-lactamase; pfam00144 1134454001995 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1134454001996 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1134454001997 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1134454001998 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1134454001999 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1134454002000 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 1134454002001 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1134454002002 active site 1134454002003 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1134454002004 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1134454002005 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 1134454002006 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1134454002007 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1134454002008 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1134454002009 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 1134454002010 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1134454002011 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1134454002012 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1134454002013 ABC-ATPase subunit interface; other site 1134454002014 dimer interface [polypeptide binding]; other site 1134454002015 putative PBP binding regions; other site 1134454002016 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1134454002017 anchored repeat-type ABC transporter, ATP-binding subunit; Region: anch_rpt_ABC; TIGR03771 1134454002018 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 1134454002019 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1134454002020 anchored repeat ABC transporter, substrate-binding protein; Region: anch_rpt_subst; TIGR03772 1134454002021 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 1134454002022 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1134454002023 putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773 1134454002024 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 1134454002025 putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773 1134454002026 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 1134454002027 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 1134454002028 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1134454002029 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1134454002030 dimer interface [polypeptide binding]; other site 1134454002031 motif 1; other site 1134454002032 active site 1134454002033 motif 2; other site 1134454002034 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1134454002035 putative deacylase active site [active] 1134454002036 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1134454002037 active site 1134454002038 motif 3; other site 1134454002039 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1134454002040 anticodon binding site; other site 1134454002041 metallophosphoesterase, PPA1498 family; Region: P_acnes_RR; TIGR03767 1134454002042 hypothetical protein; Provisional; Region: PRK10621 1134454002043 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1134454002044 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1134454002045 Sm and related proteins; Region: Sm_like; cl00259 1134454002046 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1134454002047 putative oligomer interface [polypeptide binding]; other site 1134454002048 putative RNA binding site [nucleotide binding]; other site 1134454002049 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1134454002050 NusA N-terminal domain; Region: NusA_N; pfam08529 1134454002051 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1134454002052 RNA binding site [nucleotide binding]; other site 1134454002053 homodimer interface [polypeptide binding]; other site 1134454002054 NusA-like KH domain; Region: KH_5; pfam13184 1134454002055 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1134454002056 G-X-X-G motif; other site 1134454002057 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1134454002058 translation initiation factor IF-2; Region: IF-2; TIGR00487 1134454002059 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1134454002060 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1134454002061 G1 box; other site 1134454002062 putative GEF interaction site [polypeptide binding]; other site 1134454002063 GTP/Mg2+ binding site [chemical binding]; other site 1134454002064 Switch I region; other site 1134454002065 G2 box; other site 1134454002066 G3 box; other site 1134454002067 Switch II region; other site 1134454002068 G4 box; other site 1134454002069 G5 box; other site 1134454002070 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1134454002071 Translation-initiation factor 2; Region: IF-2; pfam11987 1134454002072 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1134454002073 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1134454002074 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 1134454002075 Walker A/P-loop; other site 1134454002076 ATP binding site [chemical binding]; other site 1134454002077 Q-loop/lid; other site 1134454002078 ABC transporter signature motif; other site 1134454002079 Walker B; other site 1134454002080 D-loop; other site 1134454002081 H-loop/switch region; other site 1134454002082 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1134454002083 Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175 1134454002084 active site 1134454002085 metal binding site [ion binding]; metal-binding site 1134454002086 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1134454002087 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1134454002088 dimerization domain swap beta strand [polypeptide binding]; other site 1134454002089 regulatory protein interface [polypeptide binding]; other site 1134454002090 active site 1134454002091 regulatory phosphorylation site [posttranslational modification]; other site 1134454002092 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829 1134454002093 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 1134454002094 PTS system, glucitol/sorbitol-specific, IIBC component; Region: EIIBC-GUT; TIGR00825 1134454002095 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 1134454002096 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; pfam03608 1134454002097 Glucitol operon activator protein (GutM); Region: GutM; pfam06923 1134454002098 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1134454002099 HTH domain; Region: HTH_11; pfam08279 1134454002100 HTH domain; Region: HTH_11; pfam08279 1134454002101 PRD domain; Region: PRD; pfam00874 1134454002102 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 1134454002103 active site 1134454002104 P-loop; other site 1134454002105 phosphorylation site [posttranslational modification] 1134454002106 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359 1134454002107 active site 1134454002108 phosphorylation site [posttranslational modification] 1134454002109 Cupin domain; Region: Cupin_2; cl17218 1134454002110 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 1134454002111 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1134454002112 RNA binding site [nucleotide binding]; other site 1134454002113 active site 1134454002114 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 1134454002115 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 1134454002116 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1134454002117 Walker A/P-loop; other site 1134454002118 ATP binding site [chemical binding]; other site 1134454002119 Q-loop/lid; other site 1134454002120 ABC transporter signature motif; other site 1134454002121 Walker B; other site 1134454002122 D-loop; other site 1134454002123 H-loop/switch region; other site 1134454002124 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1134454002125 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 1134454002126 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1134454002127 dimer interface [polypeptide binding]; other site 1134454002128 conserved gate region; other site 1134454002129 ABC-ATPase subunit interface; other site 1134454002130 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1134454002131 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1134454002132 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1134454002133 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1134454002134 active site 1134454002135 Riboflavin kinase; Region: Flavokinase; smart00904 1134454002136 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1134454002137 16S/18S rRNA binding site [nucleotide binding]; other site 1134454002138 S13e-L30e interaction site [polypeptide binding]; other site 1134454002139 25S rRNA binding site [nucleotide binding]; other site 1134454002140 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 1134454002141 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 1134454002142 oligomer interface [polypeptide binding]; other site 1134454002143 RNA binding site [nucleotide binding]; other site 1134454002144 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1134454002145 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1134454002146 RNase E interface [polypeptide binding]; other site 1134454002147 trimer interface [polypeptide binding]; other site 1134454002148 active site 1134454002149 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1134454002150 putative nucleic acid binding region [nucleotide binding]; other site 1134454002151 G-X-X-G motif; other site 1134454002152 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1134454002153 RNA binding site [nucleotide binding]; other site 1134454002154 domain interface; other site 1134454002155 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1134454002156 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1134454002157 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1134454002158 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1134454002159 pyruvate dehydrogenase; Provisional; Region: PRK06546 1134454002160 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1134454002161 PYR/PP interface [polypeptide binding]; other site 1134454002162 dimer interface [polypeptide binding]; other site 1134454002163 tetramer interface [polypeptide binding]; other site 1134454002164 TPP binding site [chemical binding]; other site 1134454002165 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1134454002166 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1134454002167 TPP-binding site [chemical binding]; other site 1134454002168 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1134454002169 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1134454002170 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1134454002171 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1134454002172 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1134454002173 ssDNA binding site; other site 1134454002174 generic binding surface II; other site 1134454002175 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1134454002176 ATP binding site [chemical binding]; other site 1134454002177 putative Mg++ binding site [ion binding]; other site 1134454002178 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1134454002179 nucleotide binding region [chemical binding]; other site 1134454002180 ATP-binding site [chemical binding]; other site 1134454002181 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 1134454002182 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1134454002183 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1134454002184 S-adenosylmethionine binding site [chemical binding]; other site 1134454002185 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1134454002186 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1134454002187 active site 1134454002188 (T/H)XGH motif; other site 1134454002189 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 1134454002190 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 1134454002191 active site 1134454002192 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1134454002193 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 1134454002194 substrate binding site [chemical binding]; other site 1134454002195 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1134454002196 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1134454002197 Walker A/P-loop; other site 1134454002198 ATP binding site [chemical binding]; other site 1134454002199 Q-loop/lid; other site 1134454002200 ABC transporter signature motif; other site 1134454002201 Walker B; other site 1134454002202 D-loop; other site 1134454002203 H-loop/switch region; other site 1134454002204 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1134454002205 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1134454002206 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1134454002207 Walker A/P-loop; other site 1134454002208 ATP binding site [chemical binding]; other site 1134454002209 Q-loop/lid; other site 1134454002210 ABC transporter signature motif; other site 1134454002211 Walker B; other site 1134454002212 D-loop; other site 1134454002213 H-loop/switch region; other site 1134454002214 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1134454002215 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1134454002216 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1134454002217 dimer interface [polypeptide binding]; other site 1134454002218 conserved gate region; other site 1134454002219 putative PBP binding loops; other site 1134454002220 ABC-ATPase subunit interface; other site 1134454002221 Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565 1134454002222 putative active site [active] 1134454002223 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 1134454002224 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 1134454002225 active site 1134454002226 catalytic site [active] 1134454002227 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; pfam09261 1134454002228 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1134454002229 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1134454002230 DNA binding site [nucleotide binding] 1134454002231 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1134454002232 ligand binding site [chemical binding]; other site 1134454002233 dimerization interface [polypeptide binding]; other site 1134454002234 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1134454002235 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1134454002236 dimer interface [polypeptide binding]; other site 1134454002237 conserved gate region; other site 1134454002238 putative PBP binding loops; other site 1134454002239 ABC-ATPase subunit interface; other site 1134454002240 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1134454002241 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1134454002242 dimer interface [polypeptide binding]; other site 1134454002243 conserved gate region; other site 1134454002244 putative PBP binding loops; other site 1134454002245 ABC-ATPase subunit interface; other site 1134454002246 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1134454002247 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1134454002248 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 1134454002249 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 1134454002250 ribonuclease III; Reviewed; Region: rnc; PRK00102 1134454002251 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1134454002252 dimerization interface [polypeptide binding]; other site 1134454002253 active site 1134454002254 metal binding site [ion binding]; metal-binding site 1134454002255 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1134454002256 dsRNA binding site [nucleotide binding]; other site 1134454002257 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1134454002258 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1134454002259 DNA binding site [nucleotide binding] 1134454002260 H2TH interface [polypeptide binding]; other site 1134454002261 putative catalytic residues [active] 1134454002262 turnover-facilitating residue; other site 1134454002263 intercalation triad [nucleotide binding]; other site 1134454002264 8OG recognition residue [nucleotide binding]; other site 1134454002265 putative reading head residues; other site 1134454002266 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1134454002267 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 1134454002268 HicB family; Region: HicB; pfam05534 1134454002269 Predicted membrane protein [Function unknown]; Region: COG2246 1134454002270 GtrA-like protein; Region: GtrA; pfam04138 1134454002271 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 1134454002272 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1134454002273 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1134454002274 P loop; other site 1134454002275 GTP binding site [chemical binding]; other site 1134454002276 Predicted esterase [General function prediction only]; Region: COG0627 1134454002277 signal recognition particle protein; Provisional; Region: PRK10867 1134454002278 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1134454002279 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1134454002280 P loop; other site 1134454002281 GTP binding site [chemical binding]; other site 1134454002282 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1134454002283 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1134454002284 Amidohydrolase; Region: Amidohydro_4; pfam13147 1134454002285 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1134454002286 active site 1134454002287 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 1134454002288 hypothetical protein; Provisional; Region: PRK02821 1134454002289 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1134454002290 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1134454002291 RimM N-terminal domain; Region: RimM; pfam01782 1134454002292 PRC-barrel domain; Region: PRC; pfam05239 1134454002293 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1134454002294 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 1134454002295 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 1134454002296 putative Iron-sulfur protein interface [polypeptide binding]; other site 1134454002297 proximal heme binding site [chemical binding]; other site 1134454002298 distal heme binding site [chemical binding]; other site 1134454002299 putative dimer interface [polypeptide binding]; other site 1134454002300 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 1134454002301 L-aspartate oxidase; Provisional; Region: PRK06175 1134454002302 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1134454002303 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 1134454002304 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1134454002305 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1134454002306 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1134454002307 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1134454002308 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1134454002309 Catalytic site [active] 1134454002310 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1134454002311 RNA/DNA hybrid binding site [nucleotide binding]; other site 1134454002312 active site 1134454002313 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 1134454002314 hypothetical protein; Reviewed; Region: PRK12497 1134454002315 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1134454002316 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1134454002317 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1134454002318 Walker A motif; other site 1134454002319 ATP binding site [chemical binding]; other site 1134454002320 Walker B motif; other site 1134454002321 arginine finger; other site 1134454002322 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1134454002323 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1134454002324 DNA protecting protein DprA; Region: dprA; TIGR00732 1134454002325 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1134454002326 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1134454002327 DNA binding site [nucleotide binding] 1134454002328 active site 1134454002329 CsbD-like; Region: CsbD; pfam05532 1134454002330 hypothetical protein; Provisional; Region: PRK07906 1134454002331 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 1134454002332 putative metal binding site [ion binding]; other site 1134454002333 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1134454002334 dimer interface [polypeptide binding]; other site 1134454002335 Citrate synthase; Region: Citrate_synt; pfam00285 1134454002336 active site 1134454002337 citrylCoA binding site [chemical binding]; other site 1134454002338 NADH binding [chemical binding]; other site 1134454002339 cationic pore residues; other site 1134454002340 oxalacetate/citrate binding site [chemical binding]; other site 1134454002341 coenzyme A binding site [chemical binding]; other site 1134454002342 catalytic triad [active] 1134454002343 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1134454002344 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1134454002345 active site 1134454002346 catalytic tetrad [active] 1134454002347 conserved hypothetical protein; Region: TIGR03847 1134454002348 conserved hypothetical protein; Region: TIGR03843 1134454002349 Nicotinamide mononucleotide transporter [Coenzyme metabolism]; Region: PnuC; COG3201 1134454002350 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 1134454002351 homodimer interface [polypeptide binding]; other site 1134454002352 putative metal binding site [ion binding]; other site 1134454002353 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 1134454002354 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 1134454002355 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 1134454002356 Protein of unknown function (DUF418); Region: DUF418; cl12135 1134454002357 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1134454002358 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1134454002359 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1134454002360 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1134454002361 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1134454002362 23S rRNA binding site [nucleotide binding]; other site 1134454002363 L21 binding site [polypeptide binding]; other site 1134454002364 L13 binding site [polypeptide binding]; other site 1134454002365 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1134454002366 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 1134454002367 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1134454002368 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1134454002369 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1134454002370 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1134454002371 dimer interface [polypeptide binding]; other site 1134454002372 motif 1; other site 1134454002373 active site 1134454002374 motif 2; other site 1134454002375 motif 3; other site 1134454002376 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1134454002377 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1134454002378 putative tRNA-binding site [nucleotide binding]; other site 1134454002379 B3/4 domain; Region: B3_4; pfam03483 1134454002380 tRNA synthetase B5 domain; Region: B5; pfam03484 1134454002381 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1134454002382 dimer interface [polypeptide binding]; other site 1134454002383 motif 1; other site 1134454002384 motif 3; other site 1134454002385 motif 2; other site 1134454002386 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1134454002387 biotin synthase; Validated; Region: PRK06256 1134454002388 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1134454002389 FeS/SAM binding site; other site 1134454002390 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1134454002391 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1134454002392 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1134454002393 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1134454002394 arginine repressor; Provisional; Region: PRK03341 1134454002395 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1134454002396 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1134454002397 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1134454002398 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1134454002399 active site 1134454002400 HIGH motif; other site 1134454002401 dimer interface [polypeptide binding]; other site 1134454002402 KMSKS motif; other site 1134454002403 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1134454002404 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1134454002405 active site 1134454002406 motif I; other site 1134454002407 motif II; other site 1134454002408 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1134454002409 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1134454002410 BioY family; Region: BioY; pfam02632 1134454002411 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1134454002412 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1134454002413 Walker A/P-loop; other site 1134454002414 ATP binding site [chemical binding]; other site 1134454002415 Q-loop/lid; other site 1134454002416 ABC transporter signature motif; other site 1134454002417 Walker B; other site 1134454002418 D-loop; other site 1134454002419 H-loop/switch region; other site 1134454002420 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1134454002421 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1134454002422 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1134454002423 RNA binding surface [nucleotide binding]; other site 1134454002424 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1134454002425 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 1134454002426 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1134454002427 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1134454002428 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1134454002429 Walker A/P-loop; other site 1134454002430 ATP binding site [chemical binding]; other site 1134454002431 Q-loop/lid; other site 1134454002432 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1134454002433 ABC transporter signature motif; other site 1134454002434 Walker B; other site 1134454002435 D-loop; other site 1134454002436 H-loop/switch region; other site 1134454002437 CTP synthetase; Validated; Region: pyrG; PRK05380 1134454002438 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1134454002439 Catalytic site [active] 1134454002440 active site 1134454002441 UTP binding site [chemical binding]; other site 1134454002442 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1134454002443 active site 1134454002444 putative oxyanion hole; other site 1134454002445 catalytic triad [active] 1134454002446 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1134454002447 dimer interface [polypeptide binding]; other site 1134454002448 ADP-ribose binding site [chemical binding]; other site 1134454002449 active site 1134454002450 nudix motif; other site 1134454002451 metal binding site [ion binding]; metal-binding site 1134454002452 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1134454002453 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1134454002454 active site 1134454002455 Int/Topo IB signature motif; other site 1134454002456 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1134454002457 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1134454002458 P-loop; other site 1134454002459 Magnesium ion binding site [ion binding]; other site 1134454002460 transport-energizing ATPase, TRC40/GET3/ArsA family; Region: GET3_arsA_TRC40; TIGR00345 1134454002461 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1134454002462 Magnesium ion binding site [ion binding]; other site 1134454002463 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1134454002464 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1134454002465 RNA binding surface [nucleotide binding]; other site 1134454002466 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1134454002467 active site 1134454002468 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1134454002469 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1134454002470 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1134454002471 active site 1134454002472 HIGH motif; other site 1134454002473 nucleotide binding site [chemical binding]; other site 1134454002474 active site 1134454002475 KMSKS motif; other site 1134454002476 Predicted transcriptional regulator [Transcription]; Region: COG2378 1134454002477 WYL domain; Region: WYL; pfam13280 1134454002478 Predicted transcriptional regulator [Transcription]; Region: COG2378 1134454002479 WYL domain; Region: WYL; pfam13280 1134454002480 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 1134454002481 Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902 1134454002482 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 1134454002483 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1134454002484 ATP binding site [chemical binding]; other site 1134454002485 putative Mg++ binding site [ion binding]; other site 1134454002486 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1134454002487 nucleotide binding region [chemical binding]; other site 1134454002488 ATP-binding site [chemical binding]; other site 1134454002489 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 1134454002490 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1134454002491 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1134454002492 substrate binding site [chemical binding]; other site 1134454002493 glutamase interaction surface [polypeptide binding]; other site 1134454002494 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1134454002495 HIT family signature motif; other site 1134454002496 catalytic residue [active] 1134454002497 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1134454002498 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1134454002499 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1134454002500 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1134454002501 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1134454002502 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1134454002503 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1134454002504 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1134454002505 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1134454002506 homodimer interface [polypeptide binding]; other site 1134454002507 substrate-cofactor binding pocket; other site 1134454002508 catalytic residue [active] 1134454002509 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 1134454002510 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1134454002511 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1134454002512 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 1134454002513 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 1134454002514 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1134454002515 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1134454002516 CAAX protease self-immunity; Region: Abi; pfam02517 1134454002517 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1134454002518 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1134454002519 Bacterial transcriptional regulator; Region: IclR; pfam01614 1134454002520 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1134454002521 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1134454002522 hypothetical protein; Provisional; Region: PRK14812 1134454002523 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1134454002524 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1134454002525 putative acyl-acceptor binding pocket; other site 1134454002526 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1134454002527 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1134454002528 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1134454002529 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 1134454002530 thiamine monophosphate kinase; Provisional; Region: PRK05731 1134454002531 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1134454002532 ATP binding site [chemical binding]; other site 1134454002533 dimerization interface [polypeptide binding]; other site 1134454002534 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1134454002535 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1134454002536 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1134454002537 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1134454002538 Protein of unknown function (DUF805); Region: DUF805; pfam05656 1134454002539 peptide chain release factor 2; Validated; Region: prfB; PRK00578 1134454002540 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1134454002541 RF-1 domain; Region: RF-1; pfam00472 1134454002542 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1134454002543 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1134454002544 Walker A/P-loop; other site 1134454002545 ATP binding site [chemical binding]; other site 1134454002546 Q-loop/lid; other site 1134454002547 ABC transporter signature motif; other site 1134454002548 Walker B; other site 1134454002549 D-loop; other site 1134454002550 H-loop/switch region; other site 1134454002551 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1134454002552 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1134454002553 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1134454002554 SmpB-tmRNA interface; other site 1134454002555 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1134454002556 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1134454002557 DmpA/OAT superfamily; composed of L-aminopeptidase D-amidase/D-esterase (DmpA), ornithine acetyltransferase (OAT) and similar proteins. DmpA is an aminopeptidase that releases N-terminal D and L amino acids from peptide substrates. This group represents...; Region: DmpA_OAT; cl00603 1134454002558 DmpA/OAT superfamily; composed of L-aminopeptidase D-amidase/D-esterase (DmpA), ornithine acetyltransferase (OAT) and similar proteins. DmpA is an aminopeptidase that releases N-terminal D and L amino acids from peptide substrates. This group represents...; Region: DmpA_OAT; cl00603 1134454002559 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 1134454002560 feedback inhibition sensing region; other site 1134454002561 homohexameric interface [polypeptide binding]; other site 1134454002562 nucleotide binding site [chemical binding]; other site 1134454002563 N-acetyl-L-glutamate binding site [chemical binding]; other site 1134454002564 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 1134454002565 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1134454002566 inhibitor-cofactor binding pocket; inhibition site 1134454002567 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1134454002568 catalytic residue [active] 1134454002569 argininosuccinate lyase; Provisional; Region: PRK00855 1134454002570 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1134454002571 active sites [active] 1134454002572 tetramer interface [polypeptide binding]; other site 1134454002573 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1134454002574 Tic20-like protein; Region: Tic20; pfam09685 1134454002575 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1134454002576 Domain of unknown function (DUF4234); Region: DUF4234; pfam14018 1134454002577 Protein of unknown function (DUF1706); Region: DUF1706; cl01748 1134454002578 Protein of unknown function (DUF1706); Region: DUF1706; cl01748 1134454002579 CAMP factor (Cfa); Region: CAMP_factor; pfam07373 1134454002580 hypothetical protein; Validated; Region: PRK00228 1134454002581 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1134454002582 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1134454002583 active site 1134454002584 phosphorylation site [posttranslational modification] 1134454002585 intermolecular recognition site; other site 1134454002586 dimerization interface [polypeptide binding]; other site 1134454002587 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1134454002588 DNA binding site [nucleotide binding] 1134454002589 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1134454002590 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1134454002591 dimerization interface [polypeptide binding]; other site 1134454002592 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1134454002593 dimer interface [polypeptide binding]; other site 1134454002594 phosphorylation site [posttranslational modification] 1134454002595 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1134454002596 ATP binding site [chemical binding]; other site 1134454002597 Mg2+ binding site [ion binding]; other site 1134454002598 G-X-G motif; other site 1134454002599 Sporulation and spore germination; Region: Germane; cl11253 1134454002600 Lipoprotein LpqB beta-propeller domain; Region: Gmad1; pfam10647 1134454002601 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1134454002602 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1134454002603 active site 1134454002604 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1134454002605 30S subunit binding site; other site 1134454002606 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1134454002607 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1134454002608 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1134454002609 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 1134454002610 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 1134454002611 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 1134454002612 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1134454002613 active site 1134454002614 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1134454002615 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1134454002616 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1134454002617 active site 1134454002618 HIGH motif; other site 1134454002619 dimer interface [polypeptide binding]; other site 1134454002620 KMSKS motif; other site 1134454002621 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1134454002622 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 1134454002623 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1134454002624 ATP binding site [chemical binding]; other site 1134454002625 Mg++ binding site [ion binding]; other site 1134454002626 motif III; other site 1134454002627 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1134454002628 nucleotide binding region [chemical binding]; other site 1134454002629 ATP-binding site [chemical binding]; other site 1134454002630 tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like; Region: MiaE_2; pfam13794 1134454002631 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 1134454002632 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1134454002633 active site 1134454002634 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1134454002635 Part of AAA domain; Region: AAA_19; pfam13245 1134454002636 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1134454002637 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1134454002638 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1134454002639 Part of AAA domain; Region: AAA_19; pfam13245 1134454002640 Family description; Region: UvrD_C_2; pfam13538 1134454002641 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1134454002642 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 1134454002643 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1134454002644 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1134454002645 putative NADH binding site [chemical binding]; other site 1134454002646 putative active site [active] 1134454002647 nudix motif; other site 1134454002648 putative metal binding site [ion binding]; other site 1134454002649 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 1134454002650 AAA domain; Region: AAA_30; pfam13604 1134454002651 Family description; Region: UvrD_C_2; pfam13538 1134454002652 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 1134454002653 Part of AAA domain; Region: AAA_19; pfam13245 1134454002654 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1134454002655 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 1134454002656 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 1134454002657 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1134454002658 Part of AAA domain; Region: AAA_19; pfam13245 1134454002659 Family description; Region: UvrD_C_2; pfam13538 1134454002660 HRDC domain; Region: HRDC; pfam00570 1134454002661 Protein of unknown function DUF45; Region: DUF45; pfam01863 1134454002662 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 1134454002663 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 1134454002664 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1134454002665 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1134454002666 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1134454002667 Ligand Binding Site [chemical binding]; other site 1134454002668 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1134454002669 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1134454002670 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 1134454002671 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1134454002672 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1134454002673 dimer interface [polypeptide binding]; other site 1134454002674 conserved gate region; other site 1134454002675 putative PBP binding loops; other site 1134454002676 ABC-ATPase subunit interface; other site 1134454002677 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1134454002678 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1134454002679 dimer interface [polypeptide binding]; other site 1134454002680 conserved gate region; other site 1134454002681 putative PBP binding loops; other site 1134454002682 ABC-ATPase subunit interface; other site 1134454002683 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1134454002684 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1134454002685 Walker A/P-loop; other site 1134454002686 ATP binding site [chemical binding]; other site 1134454002687 Q-loop/lid; other site 1134454002688 ABC transporter signature motif; other site 1134454002689 Walker B; other site 1134454002690 D-loop; other site 1134454002691 H-loop/switch region; other site 1134454002692 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1134454002693 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1134454002694 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1134454002695 Walker A/P-loop; other site 1134454002696 ATP binding site [chemical binding]; other site 1134454002697 Q-loop/lid; other site 1134454002698 ABC transporter signature motif; other site 1134454002699 Walker B; other site 1134454002700 D-loop; other site 1134454002701 H-loop/switch region; other site 1134454002702 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1134454002703 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 1134454002704 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 1134454002705 ligand binding site [chemical binding]; other site 1134454002706 NAD binding site [chemical binding]; other site 1134454002707 tetramer interface [polypeptide binding]; other site 1134454002708 catalytic site [active] 1134454002709 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 1134454002710 L-serine binding site [chemical binding]; other site 1134454002711 ACT domain interface; other site 1134454002712 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1134454002713 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 1134454002714 active site 1134454002715 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 1134454002716 Predicted GTPases [General function prediction only]; Region: COG1162 1134454002717 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1134454002718 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1134454002719 GTP/Mg2+ binding site [chemical binding]; other site 1134454002720 G4 box; other site 1134454002721 G5 box; other site 1134454002722 G1 box; other site 1134454002723 Switch I region; other site 1134454002724 G2 box; other site 1134454002725 G3 box; other site 1134454002726 Switch II region; other site 1134454002727 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1134454002728 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1134454002729 hinge; other site 1134454002730 active site 1134454002731 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 1134454002732 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1134454002733 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1134454002734 DNA binding residues [nucleotide binding] 1134454002735 anti-sigma factor, TIGR02949 family; Region: anti_SigH_actin 1134454002736 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 1134454002737 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1134454002738 Histidine kinase; Region: HisKA_2; pfam07568 1134454002739 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1134454002740 ATP binding site [chemical binding]; other site 1134454002741 Mg2+ binding site [ion binding]; other site 1134454002742 G-X-G motif; other site 1134454002743 Transcription factor WhiB; Region: Whib; pfam02467 1134454002744 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 1134454002745 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1134454002746 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1134454002747 TPP-binding site [chemical binding]; other site 1134454002748 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1134454002749 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1134454002750 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1134454002751 active site 1134454002752 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1134454002753 substrate binding site [chemical binding]; other site 1134454002754 catalytic residues [active] 1134454002755 dimer interface [polypeptide binding]; other site 1134454002756 homoserine dehydrogenase; Provisional; Region: PRK06349 1134454002757 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1134454002758 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1134454002759 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1134454002760 threonine synthase; Reviewed; Region: PRK06721 1134454002761 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1134454002762 homodimer interface [polypeptide binding]; other site 1134454002763 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1134454002764 catalytic residue [active] 1134454002765 homoserine kinase; Provisional; Region: PRK01212 1134454002766 transcription termination factor Rho; Provisional; Region: PRK12678 1134454002767 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1134454002768 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1134454002769 RNA binding site [nucleotide binding]; other site 1134454002770 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1134454002771 Walker A motif; other site 1134454002772 ATP binding site [chemical binding]; other site 1134454002773 Walker B motif; other site 1134454002774 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1134454002775 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1134454002776 PCRF domain; Region: PCRF; pfam03462 1134454002777 RF-1 domain; Region: RF-1; pfam00472 1134454002778 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 1134454002779 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1134454002780 S-adenosylmethionine binding site [chemical binding]; other site 1134454002781 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1134454002782 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1134454002783 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1134454002784 putative catalytic motif [active] 1134454002785 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 1134454002786 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1134454002787 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1134454002788 F0F1 ATP synthase subunit C; Validated; Region: PRK07558 1134454002789 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1134454002790 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1134454002791 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210 1134454002792 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1134454002793 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1134454002794 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1134454002795 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1134454002796 beta subunit interaction interface [polypeptide binding]; other site 1134454002797 Walker A motif; other site 1134454002798 ATP binding site [chemical binding]; other site 1134454002799 Walker B motif; other site 1134454002800 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1134454002801 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1134454002802 core domain interface [polypeptide binding]; other site 1134454002803 delta subunit interface [polypeptide binding]; other site 1134454002804 epsilon subunit interface [polypeptide binding]; other site 1134454002805 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1134454002806 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1134454002807 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1134454002808 alpha subunit interaction interface [polypeptide binding]; other site 1134454002809 Walker A motif; other site 1134454002810 ATP binding site [chemical binding]; other site 1134454002811 Walker B motif; other site 1134454002812 inhibitor binding site; inhibition site 1134454002813 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1134454002814 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1134454002815 gamma subunit interface [polypeptide binding]; other site 1134454002816 epsilon subunit interface [polypeptide binding]; other site 1134454002817 LBP interface [polypeptide binding]; other site 1134454002818 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 1134454002819 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 1134454002820 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 1134454002821 Fe-S cluster binding site [ion binding]; other site 1134454002822 DNA binding site [nucleotide binding] 1134454002823 active site 1134454002824 MarR family; Region: MarR; pfam01047 1134454002825 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1134454002826 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1134454002827 putative substrate translocation pore; other site 1134454002828 hypothetical protein; Provisional; Region: PRK09256 1134454002829 CAMP factor (Cfa); Region: CAMP_factor; pfam07373 1134454002830 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1134454002831 dimerization interface [polypeptide binding]; other site 1134454002832 putative DNA binding site [nucleotide binding]; other site 1134454002833 putative Zn2+ binding site [ion binding]; other site 1134454002834 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1134454002835 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 1134454002836 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1134454002837 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1134454002838 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1134454002839 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1134454002840 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1134454002841 non-specific DNA binding site [nucleotide binding]; other site 1134454002842 salt bridge; other site 1134454002843 sequence-specific DNA binding site [nucleotide binding]; other site 1134454002844 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1134454002845 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 1134454002846 putative active site [active] 1134454002847 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 1134454002848 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 1134454002849 putative active site [active] 1134454002850 putative metal binding site [ion binding]; other site 1134454002851 catalytic site [active] 1134454002852 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 1134454002853 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 1134454002854 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 1134454002855 Ligand binding site; other site 1134454002856 Putative Catalytic site; other site 1134454002857 DXD motif; other site 1134454002858 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 1134454002859 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1134454002860 putative active site [active] 1134454002861 catalytic triad [active] 1134454002862 putative dimer interface [polypeptide binding]; other site 1134454002863 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1134454002864 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1134454002865 putative DNA binding site [nucleotide binding]; other site 1134454002866 putative Zn2+ binding site [ion binding]; other site 1134454002867 AsnC family; Region: AsnC_trans_reg; pfam01037 1134454002868 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1134454002869 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1134454002870 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 1134454002871 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1134454002872 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1134454002873 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1134454002874 active site 1134454002875 motif I; other site 1134454002876 motif II; other site 1134454002877 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1134454002878 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1134454002879 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1134454002880 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1134454002881 intersubunit interface [polypeptide binding]; other site 1134454002882 active site 1134454002883 catalytic residue [active] 1134454002884 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 1134454002885 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1134454002886 putative substrate translocation pore; other site 1134454002887 deoxyribose mutarotase_like; Region: deoxyribose_mutarotase; cd09269 1134454002888 active site 1134454002889 catalytic residues [active] 1134454002890 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1134454002891 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1134454002892 substrate binding site [chemical binding]; other site 1134454002893 dimer interface [polypeptide binding]; other site 1134454002894 ATP binding site [chemical binding]; other site 1134454002895 GTP-binding protein Der; Reviewed; Region: PRK03003 1134454002896 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1134454002897 G1 box; other site 1134454002898 GTP/Mg2+ binding site [chemical binding]; other site 1134454002899 Switch I region; other site 1134454002900 G2 box; other site 1134454002901 Switch II region; other site 1134454002902 G3 box; other site 1134454002903 G4 box; other site 1134454002904 G5 box; other site 1134454002905 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1134454002906 G1 box; other site 1134454002907 GTP/Mg2+ binding site [chemical binding]; other site 1134454002908 Switch I region; other site 1134454002909 G2 box; other site 1134454002910 G3 box; other site 1134454002911 Switch II region; other site 1134454002912 G4 box; other site 1134454002913 G5 box; other site 1134454002914 cytidylate kinase; Provisional; Region: cmk; PRK00023 1134454002915 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1134454002916 CMP-binding site; other site 1134454002917 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 1134454002918 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 1134454002919 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 1134454002920 active site 1134454002921 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1134454002922 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1134454002923 ABC transporter; Region: ABC_tran; pfam00005 1134454002924 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1134454002925 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1134454002926 Predicted membrane protein [Function unknown]; Region: COG1511 1134454002927 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1134454002928 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 1134454002929 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1134454002930 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1134454002931 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1134454002932 motif II; other site 1134454002933 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 1134454002934 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1134454002935 S-adenosylmethionine binding site [chemical binding]; other site 1134454002936 PAC2 family; Region: PAC2; pfam09754 1134454002937 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1134454002938 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1134454002939 substrate binding site [chemical binding]; other site 1134454002940 hexamer interface [polypeptide binding]; other site 1134454002941 metal binding site [ion binding]; metal-binding site 1134454002942 CAMP factor (Cfa); Region: CAMP_factor; pfam07373 1134454002943 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 1134454002944 putative RNA binding site [nucleotide binding]; other site 1134454002945 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1134454002946 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1134454002947 S-adenosylmethionine binding site [chemical binding]; other site 1134454002948 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1134454002949 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1134454002950 putative active site [active] 1134454002951 substrate binding site [chemical binding]; other site 1134454002952 putative cosubstrate binding site; other site 1134454002953 catalytic site [active] 1134454002954 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1134454002955 substrate binding site [chemical binding]; other site 1134454002956 primosome assembly protein PriA; Provisional; Region: PRK14873 1134454002957 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1134454002958 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1134454002959 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1134454002960 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1134454002961 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1134454002962 Flavoprotein; Region: Flavoprotein; pfam02441 1134454002963 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1134454002964 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 1134454002965 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1134454002966 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1134454002967 catalytic site [active] 1134454002968 G-X2-G-X-G-K; other site 1134454002969 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1134454002970 transcription antitermination factor NusB; Region: nusB; TIGR01951 1134454002971 putative RNA binding site [nucleotide binding]; other site 1134454002972 elongation factor P; Validated; Region: PRK00529 1134454002973 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1134454002974 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1134454002975 RNA binding site [nucleotide binding]; other site 1134454002976 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1134454002977 RNA binding site [nucleotide binding]; other site 1134454002978 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 1134454002979 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 1134454002980 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 1134454002981 putative active site [active] 1134454002982 putative metal binding site [ion binding]; other site 1134454002983 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1134454002984 dimer interface [polypeptide binding]; other site 1134454002985 active site 1134454002986 metal binding site [ion binding]; metal-binding site 1134454002987 shikimate kinase; Reviewed; Region: aroK; PRK00131 1134454002988 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1134454002989 ADP binding site [chemical binding]; other site 1134454002990 magnesium binding site [ion binding]; other site 1134454002991 putative shikimate binding site; other site 1134454002992 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1134454002993 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1134454002994 Tetramer interface [polypeptide binding]; other site 1134454002995 active site 1134454002996 FMN-binding site [chemical binding]; other site 1134454002997 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1134454002998 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1134454002999 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1134454003000 shikimate binding site; other site 1134454003001 NAD(P) binding site [chemical binding]; other site 1134454003002 YceG-like family; Region: YceG; pfam02618 1134454003003 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1134454003004 dimerization interface [polypeptide binding]; other site 1134454003005 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 1134454003006 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1134454003007 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1134454003008 motif 1; other site 1134454003009 active site 1134454003010 motif 2; other site 1134454003011 motif 3; other site 1134454003012 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1134454003013 recombination factor protein RarA; Reviewed; Region: PRK13342 1134454003014 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1134454003015 Walker A motif; other site 1134454003016 ATP binding site [chemical binding]; other site 1134454003017 Walker B motif; other site 1134454003018 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1134454003019 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1134454003020 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1134454003021 dimer interface [polypeptide binding]; other site 1134454003022 anticodon binding site; other site 1134454003023 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1134454003024 homodimer interface [polypeptide binding]; other site 1134454003025 motif 1; other site 1134454003026 active site 1134454003027 motif 2; other site 1134454003028 GAD domain; Region: GAD; pfam02938 1134454003029 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1134454003030 active site 1134454003031 motif 3; other site 1134454003032 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1134454003033 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1134454003034 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 1134454003035 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1134454003036 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 1134454003037 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 1134454003038 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 1134454003039 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1134454003040 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1134454003041 Protein of unknown function (DUF998); Region: DUF998; pfam06197 1134454003042 histidyl-tRNA synthetase; Region: hisS; TIGR00442 1134454003043 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1134454003044 dimer interface [polypeptide binding]; other site 1134454003045 motif 1; other site 1134454003046 active site 1134454003047 motif 2; other site 1134454003048 motif 3; other site 1134454003049 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1134454003050 anticodon binding site; other site 1134454003051 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1134454003052 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1134454003053 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1134454003054 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1134454003055 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1134454003056 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1134454003057 Zn2+ binding site [ion binding]; other site 1134454003058 Mg2+ binding site [ion binding]; other site 1134454003059 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1134454003060 synthetase active site [active] 1134454003061 NTP binding site [chemical binding]; other site 1134454003062 metal binding site [ion binding]; metal-binding site 1134454003063 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1134454003064 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1134454003065 Ion channel; Region: Ion_trans_2; pfam07885 1134454003066 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1134454003067 TrkA-N domain; Region: TrkA_N; pfam02254 1134454003068 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1134454003069 active site 1134454003070 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1134454003071 Protein export membrane protein; Region: SecD_SecF; pfam02355 1134454003072 Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342 1134454003073 Protein export membrane protein; Region: SecD_SecF; cl14618 1134454003074 Preprotein translocase subunit; Region: YajC; pfam02699 1134454003075 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1134454003076 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1134454003077 Walker A motif; other site 1134454003078 ATP binding site [chemical binding]; other site 1134454003079 Walker B motif; other site 1134454003080 arginine finger; other site 1134454003081 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1134454003082 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1134454003083 RuvA N terminal domain; Region: RuvA_N; pfam01330 1134454003084 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 1134454003085 active site 1134454003086 putative DNA-binding cleft [nucleotide binding]; other site 1134454003087 dimer interface [polypeptide binding]; other site 1134454003088 hypothetical protein; Validated; Region: PRK00110 1134454003089 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1134454003090 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 1134454003091 catalytic residues [active] 1134454003092 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 1134454003093 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1134454003094 putative active site [active] 1134454003095 oxyanion strand; other site 1134454003096 catalytic triad [active] 1134454003097 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1134454003098 putative active site pocket [active] 1134454003099 4-fold oligomerization interface [polypeptide binding]; other site 1134454003100 metal binding residues [ion binding]; metal-binding site 1134454003101 3-fold/trimer interface [polypeptide binding]; other site 1134454003102 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 1134454003103 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1134454003104 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1134454003105 homodimer interface [polypeptide binding]; other site 1134454003106 catalytic residue [active] 1134454003107 histidinol dehydrogenase; Region: hisD; TIGR00069 1134454003108 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1134454003109 NAD binding site [chemical binding]; other site 1134454003110 dimerization interface [polypeptide binding]; other site 1134454003111 product binding site; other site 1134454003112 substrate binding site [chemical binding]; other site 1134454003113 zinc binding site [ion binding]; other site 1134454003114 catalytic residues [active] 1134454003115 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1134454003116 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 1134454003117 active site 1134454003118 PHP Thumb interface [polypeptide binding]; other site 1134454003119 metal binding site [ion binding]; metal-binding site 1134454003120 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1134454003121 generic binding surface II; other site 1134454003122 generic binding surface I; other site 1134454003123 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1134454003124 methionine cluster; other site 1134454003125 active site 1134454003126 phosphorylation site [posttranslational modification] 1134454003127 metal binding site [ion binding]; metal-binding site 1134454003128 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1134454003129 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1134454003130 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1134454003131 active site 1134454003132 P-loop; other site 1134454003133 phosphorylation site [posttranslational modification] 1134454003134 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1134454003135 beta-galactosidase; Region: BGL; TIGR03356 1134454003136 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1134454003137 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1134454003138 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 1134454003139 active site turn [active] 1134454003140 phosphorylation site [posttranslational modification] 1134454003141 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1134454003142 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 1134454003143 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1134454003144 putative active site [active] 1134454003145 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1134454003146 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1134454003147 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1134454003148 putative active site [active] 1134454003149 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 1134454003150 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1134454003151 Beta-lactamase; Region: Beta-lactamase; cl17358 1134454003152 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 1134454003153 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1134454003154 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1134454003155 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1134454003156 active site 1134454003157 dimer interface [polypeptide binding]; other site 1134454003158 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1134454003159 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1134454003160 active site 1134454003161 FMN binding site [chemical binding]; other site 1134454003162 substrate binding site [chemical binding]; other site 1134454003163 3Fe-4S cluster binding site [ion binding]; other site 1134454003164 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1134454003165 domain interface; other site 1134454003166 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1134454003167 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1134454003168 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1134454003169 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1134454003170 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1134454003171 catalytic residue [active] 1134454003172 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1134454003173 active site 1134454003174 ribulose/triose binding site [chemical binding]; other site 1134454003175 phosphate binding site [ion binding]; other site 1134454003176 substrate (anthranilate) binding pocket [chemical binding]; other site 1134454003177 product (indole) binding pocket [chemical binding]; other site 1134454003178 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; cl17850 1134454003179 anthranilate synthase component I; Provisional; Region: PRK13571 1134454003180 anthranilate synthase component I; Provisional; Region: PRK13571 1134454003181 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1134454003182 TIGR03085 family protein; Region: TIGR03085 1134454003183 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1134454003184 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1134454003185 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1134454003186 GatB domain; Region: GatB_Yqey; smart00845 1134454003187 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1134454003188 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1134454003189 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1134454003190 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 1134454003191 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 1134454003192 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 1134454003193 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1134454003194 Ligand Binding Site [chemical binding]; other site 1134454003195 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1134454003196 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1134454003197 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1134454003198 catalytic residue [active] 1134454003199 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1134454003200 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1134454003201 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1134454003202 active site 1134454003203 catalytic site [active] 1134454003204 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 1134454003205 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 1134454003206 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1134454003207 active site 1134454003208 homodimer interface [polypeptide binding]; other site 1134454003209 catalytic site [active] 1134454003210 acceptor binding site [chemical binding]; other site 1134454003211 trehalose synthase; Region: treS_nterm; TIGR02456 1134454003212 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 1134454003213 active site 1134454003214 catalytic site [active] 1134454003215 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 1134454003216 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 1134454003217 glycogen branching enzyme; Provisional; Region: PRK12313 1134454003218 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1134454003219 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1134454003220 active site 1134454003221 catalytic site [active] 1134454003222 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1134454003223 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1134454003224 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1134454003225 nudix motif; other site 1134454003226 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1134454003227 active site turn [active] 1134454003228 phosphorylation site [posttranslational modification] 1134454003229 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1134454003230 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 1134454003231 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1134454003232 HPr interaction site; other site 1134454003233 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1134454003234 active site 1134454003235 phosphorylation site [posttranslational modification] 1134454003236 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 1134454003237 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1134454003238 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1134454003239 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1134454003240 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1134454003241 motif II; other site 1134454003242 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1134454003243 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1134454003244 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 1134454003245 phosphoglucomutase; Validated; Region: PRK07564 1134454003246 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 1134454003247 active site 1134454003248 substrate binding site [chemical binding]; other site 1134454003249 metal binding site [ion binding]; metal-binding site 1134454003250 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 1134454003251 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1134454003252 dimer interface [polypeptide binding]; other site 1134454003253 substrate binding site [chemical binding]; other site 1134454003254 metal binding site [ion binding]; metal-binding site 1134454003255 DivIVA protein; Region: DivIVA; pfam05103 1134454003256 V-type ATP synthase subunit E; Provisional; Region: PRK01558 1134454003257 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1134454003258 hypothetical protein; Provisional; Region: PRK03298 1134454003259 acyl-CoA esterase; Provisional; Region: PRK10673 1134454003260 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 1134454003261 active site 1134454003262 PAC2 family; Region: PAC2; pfam09754 1134454003263 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1134454003264 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1134454003265 Uncharacterized conserved protein [Function unknown]; Region: COG1739 1134454003266 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1134454003267 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1134454003268 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1134454003269 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 1134454003270 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1134454003271 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 1134454003272 pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated; Region: PRK06555 1134454003273 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 1134454003274 active site 1134454003275 ADP/pyrophosphate binding site [chemical binding]; other site 1134454003276 fructose-1,6-bisphosphate binding site; other site 1134454003277 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1134454003278 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 1134454003279 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1134454003280 DNA binding residues [nucleotide binding] 1134454003281 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1134454003282 putative dimer interface [polypeptide binding]; other site 1134454003283 Bifunctional nuclease; Region: DNase-RNase; pfam02577 1134454003284 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1134454003285 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1134454003286 DNA binding residues [nucleotide binding] 1134454003287 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1134454003288 Double zinc ribbon; Region: DZR; pfam12773 1134454003289 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1134454003290 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1134454003291 phosphopeptide binding site; other site 1134454003292 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1134454003293 lipoyl attachment site [posttranslational modification]; other site 1134454003294 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 1134454003295 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1134454003296 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 1134454003297 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1134454003298 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1134454003299 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1134454003300 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 1134454003301 nucleotide binding site/active site [active] 1134454003302 HIT family signature motif; other site 1134454003303 catalytic residue [active] 1134454003304 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 1134454003305 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 1134454003306 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1134454003307 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1134454003308 active site 1134454003309 dimer interface [polypeptide binding]; other site 1134454003310 motif 1; other site 1134454003311 motif 2; other site 1134454003312 motif 3; other site 1134454003313 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1134454003314 anticodon binding site; other site 1134454003315 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1134454003316 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1134454003317 active site 1134454003318 phosphorylation site [posttranslational modification] 1134454003319 intermolecular recognition site; other site 1134454003320 dimerization interface [polypeptide binding]; other site 1134454003321 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1134454003322 DNA binding residues [nucleotide binding] 1134454003323 dimerization interface [polypeptide binding]; other site 1134454003324 LrgB-like family; Region: LrgB; cl00596 1134454003325 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1134454003326 Histidine kinase; Region: HisKA_3; pfam07730 1134454003327 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1134454003328 ATP binding site [chemical binding]; other site 1134454003329 Mg2+ binding site [ion binding]; other site 1134454003330 G-X-G motif; other site 1134454003331 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1134454003332 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1134454003333 putative NAD(P) binding site [chemical binding]; other site 1134454003334 putative substrate binding site [chemical binding]; other site 1134454003335 catalytic Zn binding site [ion binding]; other site 1134454003336 structural Zn binding site [ion binding]; other site 1134454003337 dimer interface [polypeptide binding]; other site 1134454003338 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 1134454003339 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1134454003340 tryptophanase/L-cysteine desulfhydrase, PLP-dependent; Provisional; Region: tnaA; PRK13238 1134454003341 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1134454003342 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1134454003343 catalytic residue [active] 1134454003344 YheO-like PAS domain; Region: PAS_6; pfam08348 1134454003345 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 1134454003346 HTH domain; Region: HTH_22; pfam13309 1134454003347 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 1134454003348 active site 1134454003349 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 1134454003350 SelR domain; Region: SelR; pfam01641 1134454003351 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 1134454003352 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 1134454003353 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1134454003354 catalytic site [active] 1134454003355 putative active site [active] 1134454003356 putative substrate binding site [chemical binding]; other site 1134454003357 HRDC domain; Region: HRDC; pfam00570 1134454003358 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1134454003359 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1134454003360 TPP-binding site; other site 1134454003361 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1134454003362 PYR/PP interface [polypeptide binding]; other site 1134454003363 dimer interface [polypeptide binding]; other site 1134454003364 TPP binding site [chemical binding]; other site 1134454003365 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1134454003366 aconitate hydratase; Validated; Region: PRK09277 1134454003367 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1134454003368 substrate binding site [chemical binding]; other site 1134454003369 ligand binding site [chemical binding]; other site 1134454003370 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1134454003371 substrate binding site [chemical binding]; other site 1134454003372 TRAM domain; Region: TRAM; cl01282 1134454003373 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1134454003374 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1134454003375 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1134454003376 TrkA-N domain; Region: TrkA_N; pfam02254 1134454003377 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1134454003378 TrkA-N domain; Region: TrkA_N; pfam02254 1134454003379 TrkA-C domain; Region: TrkA_C; pfam02080 1134454003380 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1134454003381 ssDNA binding site; other site 1134454003382 generic binding surface II; other site 1134454003383 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 1134454003384 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1134454003385 trimer interface [polypeptide binding]; other site 1134454003386 active site 1134454003387 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 1134454003388 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 1134454003389 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 1134454003390 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 1134454003391 thymidine kinase; Provisional; Region: PRK04296 1134454003392 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 1134454003393 Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; cl17415 1134454003394 Uncharacterized conserved protein [Function unknown]; Region: COG4850 1134454003395 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 1134454003396 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 1134454003397 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1134454003398 CAP-like domain; other site 1134454003399 active site 1134454003400 primary dimer interface [polypeptide binding]; other site 1134454003401 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 1134454003402 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1134454003403 putative substrate translocation pore; other site 1134454003404 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 1134454003405 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 1134454003406 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 1134454003407 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1134454003408 Mg2+ binding site [ion binding]; other site 1134454003409 G-X-G motif; other site 1134454003410 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1134454003411 anchoring element; other site 1134454003412 dimer interface [polypeptide binding]; other site 1134454003413 ATP binding site [chemical binding]; other site 1134454003414 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1134454003415 active site 1134454003416 metal binding site [ion binding]; metal-binding site 1134454003417 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1134454003418 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1134454003419 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1134454003420 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 1134454003421 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1134454003422 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1134454003423 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1134454003424 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1134454003425 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1134454003426 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1134454003427 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1134454003428 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 1134454003429 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1134454003430 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1134454003431 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1134454003432 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 1134454003433 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1134454003434 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1134454003435 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1134454003436 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1134454003437 DNA binding residues [nucleotide binding] 1134454003438 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 1134454003439 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1134454003440 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1134454003441 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1134454003442 Sigma-70, region 4; Region: Sigma70_r4; pfam04545 1134454003443 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 1134454003444 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1134454003445 active site 1134454003446 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1134454003447 catalytic triad [active] 1134454003448 dimer interface [polypeptide binding]; other site 1134454003449 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 1134454003450 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1134454003451 ATP binding site [chemical binding]; other site 1134454003452 putative Mg++ binding site [ion binding]; other site 1134454003453 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1134454003454 nucleotide binding region [chemical binding]; other site 1134454003455 ATP-binding site [chemical binding]; other site 1134454003456 Helicase associated domain (HA2); Region: HA2; pfam04408 1134454003457 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 1134454003458 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 1134454003459 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1134454003460 Ligand Binding Site [chemical binding]; other site 1134454003461 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1134454003462 Ligand Binding Site [chemical binding]; other site 1134454003463 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1134454003464 vitamin B12-dependent ribonucleotide reductase; Validated; Region: PRK06556 1134454003465 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 1134454003466 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 1134454003467 active site 1134454003468 dimer interface [polypeptide binding]; other site 1134454003469 effector binding site; other site 1134454003470 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1134454003471 TSCPD domain; Region: TSCPD; pfam12637 1134454003472 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1134454003473 ATP cone domain; Region: ATP-cone; pfam03477 1134454003474 LexA repressor; Validated; Region: PRK00215 1134454003475 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1134454003476 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1134454003477 Catalytic site [active] 1134454003478 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1134454003479 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1134454003480 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1134454003481 putative Mg++ binding site [ion binding]; other site 1134454003482 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1134454003483 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1134454003484 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1134454003485 HflX GTPase family; Region: HflX; cd01878 1134454003486 G1 box; other site 1134454003487 GTP/Mg2+ binding site [chemical binding]; other site 1134454003488 Switch I region; other site 1134454003489 G2 box; other site 1134454003490 G3 box; other site 1134454003491 Switch II region; other site 1134454003492 G4 box; other site 1134454003493 G5 box; other site 1134454003494 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1134454003495 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1134454003496 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1134454003497 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1134454003498 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1134454003499 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 1134454003500 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 1134454003501 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1134454003502 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1134454003503 FeS/SAM binding site; other site 1134454003504 Predicted membrane protein [Function unknown]; Region: COG1288 1134454003505 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1134454003506 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 1134454003507 active site 1134454003508 catalytic residues [active] 1134454003509 hypothetical protein; Provisional; Region: PRK12705 1134454003510 KH domain; Region: KH_1; pfam00013 1134454003511 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1134454003512 Zn2+ binding site [ion binding]; other site 1134454003513 Mg2+ binding site [ion binding]; other site 1134454003514 recombination regulator RecX; Reviewed; Region: recX; PRK00117 1134454003515 recombinase A; Provisional; Region: recA; PRK09354 1134454003516 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1134454003517 hexamer interface [polypeptide binding]; other site 1134454003518 Walker A motif; other site 1134454003519 ATP binding site [chemical binding]; other site 1134454003520 Walker B motif; other site 1134454003521 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 1134454003522 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1134454003523 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1134454003524 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1134454003525 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1134454003526 non-specific DNA binding site [nucleotide binding]; other site 1134454003527 salt bridge; other site 1134454003528 sequence-specific DNA binding site [nucleotide binding]; other site 1134454003529 Competence-damaged protein; Region: CinA; pfam02464 1134454003530 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1134454003531 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 1134454003532 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1134454003533 Fructosamine kinase; Region: Fructosamin_kin; cl17579 1134454003534 Phosphotransferase enzyme family; Region: APH; pfam01636 1134454003535 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1134454003536 active site 1134454003537 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1134454003538 active site 1134454003539 dimer interface [polypeptide binding]; other site 1134454003540 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 1134454003541 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 1134454003542 heterodimer interface [polypeptide binding]; other site 1134454003543 active site 1134454003544 FMN binding site [chemical binding]; other site 1134454003545 homodimer interface [polypeptide binding]; other site 1134454003546 substrate binding site [chemical binding]; other site 1134454003547 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 1134454003548 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 1134454003549 FAD binding pocket [chemical binding]; other site 1134454003550 FAD binding motif [chemical binding]; other site 1134454003551 phosphate binding motif [ion binding]; other site 1134454003552 beta-alpha-beta structure motif; other site 1134454003553 NAD binding pocket [chemical binding]; other site 1134454003554 Iron coordination center [ion binding]; other site 1134454003555 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1134454003556 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1134454003557 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1134454003558 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1134454003559 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1134454003560 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1134454003561 MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245 1134454003562 substrate binding site [chemical binding]; other site 1134454003563 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1134454003564 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 1134454003565 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1134454003566 catalytic site [active] 1134454003567 subunit interface [polypeptide binding]; other site 1134454003568 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1134454003569 dihydroorotase; Validated; Region: pyrC; PRK09357 1134454003570 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1134454003571 active site 1134454003572 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1134454003573 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1134454003574 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1134454003575 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1134454003576 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1134454003577 active site 1134454003578 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 1134454003579 Isochorismatase family; Region: Isochorismatase; pfam00857 1134454003580 catalytic triad [active] 1134454003581 metal binding site [ion binding]; metal-binding site 1134454003582 conserved cis-peptide bond; other site 1134454003583 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 1134454003584 Endo-beta-N-acetylglucosaminidases are bacterial chitinases that hydrolyze the chitin core of various asparagine (N)-linked glycans and glycoproteins. The endo-beta-N-acetylglucosaminidases have a glycosyl hydrolase family 18 (GH18) catalytic domain; Region: GH18_EndoS-like; cd06542 1134454003585 active site 1134454003586 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 1134454003587 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1134454003588 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1134454003589 dimer interface [polypeptide binding]; other site 1134454003590 TPP-binding site [chemical binding]; other site 1134454003591 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1134454003592 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1134454003593 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1134454003594 putative substrate translocation pore; other site 1134454003595 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1134454003596 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cl00252 1134454003597 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1134454003598 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1134454003599 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1134454003600 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1134454003601 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1134454003602 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1134454003603 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1134454003604 dimer interface [polypeptide binding]; other site 1134454003605 active site 1134454003606 CoA binding pocket [chemical binding]; other site 1134454003607 acyl carrier protein; Provisional; Region: acpP; PRK00982 1134454003608 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1134454003609 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1134454003610 dimer interface [polypeptide binding]; other site 1134454003611 active site 1134454003612 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 1134454003613 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1134454003614 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1134454003615 catalytic residue [active] 1134454003616 von Willebrand factor type A domain; Region: VWA_2; pfam13519 1134454003617 metal ion-dependent adhesion site (MIDAS); other site 1134454003618 hypothetical protein; Provisional; Region: PRK13685 1134454003619 von Willebrand factor type A domain; Region: VWA_2; pfam13519 1134454003620 metal ion-dependent adhesion site (MIDAS); other site 1134454003621 Protein-interacting Bro1-like domain of mammalian Alix and related domains; Region: BRO1_Alix_like; cl14649 1134454003622 Protein of unknown function DUF58; Region: DUF58; pfam01882 1134454003623 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1134454003624 MoxR-like ATPases [General function prediction only]; Region: COG0714 1134454003625 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1134454003626 Walker A motif; other site 1134454003627 ATP binding site [chemical binding]; other site 1134454003628 Walker B motif; other site 1134454003629 arginine finger; other site 1134454003630 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1134454003631 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1134454003632 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1134454003633 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1134454003634 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 1134454003635 inhibitor-cofactor binding pocket; inhibition site 1134454003636 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1134454003637 catalytic residue [active] 1134454003638 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1134454003639 predicted active site [active] 1134454003640 catalytic triad [active] 1134454003641 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1134454003642 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1134454003643 active site 1134454003644 multimer interface [polypeptide binding]; other site 1134454003645 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1134454003646 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1134454003647 DNA-binding site [nucleotide binding]; DNA binding site 1134454003648 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1134454003649 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1134454003650 homodimer interface [polypeptide binding]; other site 1134454003651 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1134454003652 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1134454003653 dimer interface [polypeptide binding]; other site 1134454003654 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1134454003655 catalytic residue [active] 1134454003656 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 1134454003657 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 1134454003658 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 1134454003659 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 1134454003660 active site 1134454003661 homotetramer interface [polypeptide binding]; other site 1134454003662 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 1134454003663 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1134454003664 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1134454003665 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1134454003666 DNA-directed RNA polymerase specialized sigma subunit [Transcription]; Region: FliA; COG1191 1134454003667 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1134454003668 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1134454003669 DNA binding residues [nucleotide binding] 1134454003670 DNA primase; Validated; Region: dnaG; PRK05667 1134454003671 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1134454003672 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1134454003673 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1134454003674 active site 1134454003675 metal binding site [ion binding]; metal-binding site 1134454003676 interdomain interaction site; other site 1134454003677 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1134454003678 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 1134454003679 Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424 1134454003680 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1134454003681 Zn2+ binding site [ion binding]; other site 1134454003682 Mg2+ binding site [ion binding]; other site 1134454003683 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1134454003684 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1134454003685 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1134454003686 FMN binding site [chemical binding]; other site 1134454003687 active site 1134454003688 catalytic residues [active] 1134454003689 substrate binding site [chemical binding]; other site 1134454003690 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 1134454003691 putative FMN binding site [chemical binding]; other site 1134454003692 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 1134454003693 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1134454003694 putative dimer interface [polypeptide binding]; other site 1134454003695 active site pocket [active] 1134454003696 putative cataytic base [active] 1134454003697 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 1134454003698 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1134454003699 4Fe-4S binding domain; Region: Fer4; pfam00037 1134454003700 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 1134454003701 L-aspartate oxidase; Provisional; Region: PRK06175 1134454003702 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1134454003703 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 1134454003704 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 1134454003705 proximal heme binding site [chemical binding]; other site 1134454003706 distal heme binding site [chemical binding]; other site 1134454003707 putative dimer interface [polypeptide binding]; other site 1134454003708 putative Iron-sulfur protein interface [polypeptide binding]; other site 1134454003709 glycyl-tRNA synthetase; Provisional; Region: PRK04173 1134454003710 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1134454003711 motif 1; other site 1134454003712 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 1134454003713 active site 1134454003714 motif 2; other site 1134454003715 motif 3; other site 1134454003716 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 1134454003717 anticodon binding site; other site 1134454003718 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1134454003719 metal binding site 2 [ion binding]; metal-binding site 1134454003720 putative DNA binding helix; other site 1134454003721 metal binding site 1 [ion binding]; metal-binding site 1134454003722 dimer interface [polypeptide binding]; other site 1134454003723 structural Zn2+ binding site [ion binding]; other site 1134454003724 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1134454003725 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1134454003726 active site 1134454003727 phosphorylation site [posttranslational modification] 1134454003728 intermolecular recognition site; other site 1134454003729 dimerization interface [polypeptide binding]; other site 1134454003730 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1134454003731 DNA binding residues [nucleotide binding] 1134454003732 dimerization interface [polypeptide binding]; other site 1134454003733 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1134454003734 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1134454003735 Recombination protein O N terminal; Region: RecO_N; pfam11967 1134454003736 Recombination protein O C terminal; Region: RecO_C; pfam02565 1134454003737 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 1134454003738 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1134454003739 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 1134454003740 catalytic residue [active] 1134454003741 putative FPP diphosphate binding site; other site 1134454003742 putative FPP binding hydrophobic cleft; other site 1134454003743 dimer interface [polypeptide binding]; other site 1134454003744 putative IPP diphosphate binding site; other site 1134454003745 2-isopropylmalate synthase; Validated; Region: PRK03739 1134454003746 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 1134454003747 active site 1134454003748 catalytic residues [active] 1134454003749 metal binding site [ion binding]; metal-binding site 1134454003750 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1134454003751 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1134454003752 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1134454003753 active site 1134454003754 GTPase Era; Reviewed; Region: era; PRK00089 1134454003755 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1134454003756 G1 box; other site 1134454003757 GTP/Mg2+ binding site [chemical binding]; other site 1134454003758 Switch I region; other site 1134454003759 G2 box; other site 1134454003760 Switch II region; other site 1134454003761 G3 box; other site 1134454003762 G4 box; other site 1134454003763 G5 box; other site 1134454003764 KH domain; Region: KH_2; pfam07650 1134454003765 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1134454003766 Domain of unknown function DUF21; Region: DUF21; pfam01595 1134454003767 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1134454003768 Transporter associated domain; Region: CorC_HlyC; smart01091 1134454003769 metal-binding heat shock protein; Provisional; Region: PRK00016 1134454003770 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1134454003771 PhoH-like protein; Region: PhoH; pfam02562 1134454003772 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 1134454003773 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1134454003774 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 1134454003775 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1134454003776 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 1134454003777 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1134454003778 Walker A/P-loop; other site 1134454003779 ATP binding site [chemical binding]; other site 1134454003780 Q-loop/lid; other site 1134454003781 ABC transporter signature motif; other site 1134454003782 Walker B; other site 1134454003783 D-loop; other site 1134454003784 H-loop/switch region; other site 1134454003785 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1134454003786 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1134454003787 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1134454003788 active site 1134454003789 phosphorylation site [posttranslational modification] 1134454003790 intermolecular recognition site; other site 1134454003791 dimerization interface [polypeptide binding]; other site 1134454003792 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1134454003793 DNA binding residues [nucleotide binding] 1134454003794 dimerization interface [polypeptide binding]; other site 1134454003795 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1134454003796 Histidine kinase; Region: HisKA_3; pfam07730 1134454003797 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1134454003798 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 1134454003799 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1134454003800 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1134454003801 EamA-like transporter family; Region: EamA; pfam00892 1134454003802 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1134454003803 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1134454003804 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1134454003805 ATP binding site [chemical binding]; other site 1134454003806 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1134454003807 putative Mg++ binding site [ion binding]; other site 1134454003808 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1134454003809 nucleotide binding region [chemical binding]; other site 1134454003810 ATP-binding site [chemical binding]; other site 1134454003811 Predicted membrane protein [Function unknown]; Region: COG2259 1134454003812 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1134454003813 L-iditol 2-dehydrogenase; Region: iditol_2_DH_like; cd08235 1134454003814 putative NAD(P) binding site [chemical binding]; other site 1134454003815 catalytic Zn binding site [ion binding]; other site 1134454003816 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 1134454003817 RNA methyltransferase, RsmE family; Region: TIGR00046 1134454003818 chaperone protein DnaJ; Provisional; Region: PRK14278 1134454003819 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1134454003820 HSP70 interaction site [polypeptide binding]; other site 1134454003821 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1134454003822 Zn binding sites [ion binding]; other site 1134454003823 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1134454003824 dimer interface [polypeptide binding]; other site 1134454003825 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1134454003826 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1134454003827 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1134454003828 active site 1134454003829 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 1134454003830 coproporphyrinogen III oxidase; Validated; Region: PRK05628 1134454003831 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1134454003832 FeS/SAM binding site; other site 1134454003833 HemN C-terminal domain; Region: HemN_C; pfam06969 1134454003834 Rhomboid family; Region: Rhomboid; pfam01694 1134454003835 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1134454003836 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1134454003837 substrate binding site [chemical binding]; other site 1134454003838 oxyanion hole (OAH) forming residues; other site 1134454003839 trimer interface [polypeptide binding]; other site 1134454003840 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1134454003841 acyl-activating enzyme (AAE) consensus motif; other site 1134454003842 AMP binding site [chemical binding]; other site 1134454003843 active site 1134454003844 CoA binding site [chemical binding]; other site 1134454003845 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 1134454003846 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1134454003847 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase; Region: menD; TIGR00173 1134454003848 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1134454003849 dimer interface [polypeptide binding]; other site 1134454003850 tetramer interface [polypeptide binding]; other site 1134454003851 PYR/PP interface [polypeptide binding]; other site 1134454003852 TPP binding site [chemical binding]; other site 1134454003853 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1134454003854 TPP-binding site [chemical binding]; other site 1134454003855 O-succinylbenzoate synthase; Provisional; Region: PRK02901 1134454003856 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 1134454003857 active site 1134454003858 GTP-binding protein LepA; Provisional; Region: PRK05433 1134454003859 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1134454003860 G1 box; other site 1134454003861 putative GEF interaction site [polypeptide binding]; other site 1134454003862 GTP/Mg2+ binding site [chemical binding]; other site 1134454003863 Switch I region; other site 1134454003864 G2 box; other site 1134454003865 G3 box; other site 1134454003866 Switch II region; other site 1134454003867 G4 box; other site 1134454003868 G5 box; other site 1134454003869 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 1134454003870 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1134454003871 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1134454003872 Alpha amylase catalytic domain found in Amylosucrase; Region: AmyAc_Amylosucrase; cd11324 1134454003873 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1134454003874 active site 1134454003875 catalytic site [active] 1134454003876 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1134454003877 hypothetical protein; Reviewed; Region: PRK07914 1134454003878 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1134454003879 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1134454003880 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1134454003881 ATP binding site [chemical binding]; other site 1134454003882 putative Mg++ binding site [ion binding]; other site 1134454003883 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1134454003884 Competence protein; Region: Competence; pfam03772 1134454003885 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 1134454003886 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1134454003887 SLBB domain; Region: SLBB; pfam10531 1134454003888 comEA protein; Region: comE; TIGR01259 1134454003889 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1134454003890 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1134454003891 HIGH motif; other site 1134454003892 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1134454003893 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1134454003894 active site 1134454003895 KMSKS motif; other site 1134454003896 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1134454003897 tRNA binding surface [nucleotide binding]; other site 1134454003898 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 1134454003899 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 1134454003900 malate dehydrogenase; Provisional; Region: PRK13529 1134454003901 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1134454003902 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1134454003903 NAD(P) binding site [chemical binding]; other site 1134454003904 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 1134454003905 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 1134454003906 dimer interface [polypeptide binding]; other site 1134454003907 NAD binding site [chemical binding]; other site 1134454003908 substrate binding site [chemical binding]; other site 1134454003909 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1134454003910 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1134454003911 thiamine phosphate binding site [chemical binding]; other site 1134454003912 active site 1134454003913 pyrophosphate binding site [ion binding]; other site 1134454003914 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1134454003915 substrate binding site [chemical binding]; other site 1134454003916 multimerization interface [polypeptide binding]; other site 1134454003917 ATP binding site [chemical binding]; other site 1134454003918 benzoate transport; Region: 2A0115; TIGR00895 1134454003919 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1134454003920 putative substrate translocation pore; other site 1134454003921 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1134454003922 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1134454003923 substrate binding site [chemical binding]; other site 1134454003924 ATP binding site [chemical binding]; other site 1134454003925 L-ribulose-5-phosphate 4-epimerase; Validated; Region: PRK06557 1134454003926 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1134454003927 intersubunit interface [polypeptide binding]; other site 1134454003928 active site 1134454003929 Zn2+ binding site [ion binding]; other site 1134454003930 L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209 1134454003931 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1134454003932 AP (apurinic/apyrimidinic) site pocket; other site 1134454003933 DNA interaction; other site 1134454003934 Metal-binding active site; metal-binding site 1134454003935 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 1134454003936 active site 1134454003937 dimer interface [polypeptide binding]; other site 1134454003938 magnesium binding site [ion binding]; other site 1134454003939 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 1134454003940 active site 1134454003941 substrate binding pocket [chemical binding]; other site 1134454003942 homodimer interaction site [polypeptide binding]; other site 1134454003943 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1134454003944 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1134454003945 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1134454003946 MarR family; Region: MarR_2; pfam12802 1134454003947 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1134454003948 Walker A/P-loop; other site 1134454003949 ATP binding site [chemical binding]; other site 1134454003950 Q-loop/lid; other site 1134454003951 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1134454003952 ABC transporter signature motif; other site 1134454003953 Walker B; other site 1134454003954 D-loop; other site 1134454003955 H-loop/switch region; other site 1134454003956 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1134454003957 Walker A/P-loop; other site 1134454003958 ATP binding site [chemical binding]; other site 1134454003959 Q-loop/lid; other site 1134454003960 ABC transporter signature motif; other site 1134454003961 Walker B; other site 1134454003962 D-loop; other site 1134454003963 H-loop/switch region; other site 1134454003964 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1134454003965 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1134454003966 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1134454003967 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1134454003968 active site 1134454003969 phosphorylation site [posttranslational modification] 1134454003970 intermolecular recognition site; other site 1134454003971 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1134454003972 DNA binding residues [nucleotide binding] 1134454003973 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1134454003974 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1134454003975 ATP binding site [chemical binding]; other site 1134454003976 Mg2+ binding site [ion binding]; other site 1134454003977 G-X-G motif; other site 1134454003978 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1134454003979 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1134454003980 Walker A/P-loop; other site 1134454003981 ATP binding site [chemical binding]; other site 1134454003982 Q-loop/lid; other site 1134454003983 ABC transporter signature motif; other site 1134454003984 Walker B; other site 1134454003985 D-loop; other site 1134454003986 H-loop/switch region; other site 1134454003987 FtsX-like permease family; Region: FtsX; pfam02687 1134454003988 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1134454003989 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1134454003990 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1134454003991 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1134454003992 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1134454003993 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1134454003994 H-loop/switch region; other site 1134454003995 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1134454003996 Walker A/P-loop; other site 1134454003997 ATP binding site [chemical binding]; other site 1134454003998 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1134454003999 substrate binding site [chemical binding]; other site 1134454004000 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1134454004001 catalytic core [active] 1134454004002 Oligomerisation domain; Region: Oligomerisation; pfam02410 1134454004003 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1134454004004 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1134454004005 active site 1134454004006 (T/H)XGH motif; other site 1134454004007 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1134454004008 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1134454004009 putative catalytic cysteine [active] 1134454004010 gamma-glutamyl kinase; Provisional; Region: PRK05429 1134454004011 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1134454004012 nucleotide binding site [chemical binding]; other site 1134454004013 homotetrameric interface [polypeptide binding]; other site 1134454004014 putative phosphate binding site [ion binding]; other site 1134454004015 putative allosteric binding site; other site 1134454004016 PUA domain; Region: PUA; pfam01472 1134454004017 GTPase CgtA; Reviewed; Region: obgE; PRK12296 1134454004018 GTP1/OBG; Region: GTP1_OBG; pfam01018 1134454004019 Obg GTPase; Region: Obg; cd01898 1134454004020 G1 box; other site 1134454004021 GTP/Mg2+ binding site [chemical binding]; other site 1134454004022 Switch I region; other site 1134454004023 G2 box; other site 1134454004024 G3 box; other site 1134454004025 Switch II region; other site 1134454004026 G4 box; other site 1134454004027 G5 box; other site 1134454004028 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1134454004029 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1134454004030 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1134454004031 putative substrate translocation pore; other site 1134454004032 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1134454004033 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1134454004034 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1134454004035 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 1134454004036 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1134454004037 homodimer interface [polypeptide binding]; other site 1134454004038 oligonucleotide binding site [chemical binding]; other site 1134454004039 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 1134454004040 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105 1134454004041 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 1134454004042 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1134454004043 B12 binding site [chemical binding]; other site 1134454004044 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1134454004045 FeS/SAM binding site; other site 1134454004046 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1134454004047 active site 1134454004048 multimer interface [polypeptide binding]; other site 1134454004049 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 1134454004050 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1134454004051 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1134454004052 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 1134454004053 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1134454004054 triosephosphate isomerase; Provisional; Region: PRK14567 1134454004055 substrate binding site [chemical binding]; other site 1134454004056 dimer interface [polypeptide binding]; other site 1134454004057 catalytic triad [active] 1134454004058 Phosphoglycerate kinase; Region: PGK; pfam00162 1134454004059 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1134454004060 substrate binding site [chemical binding]; other site 1134454004061 hinge regions; other site 1134454004062 ADP binding site [chemical binding]; other site 1134454004063 catalytic site [active] 1134454004064 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1134454004065 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1134454004066 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1134454004067 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1134454004068 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1134454004069 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1134454004070 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1134454004071 phosphate binding site [ion binding]; other site 1134454004072 putative substrate binding pocket [chemical binding]; other site 1134454004073 dimer interface [polypeptide binding]; other site 1134454004074 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1134454004075 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1134454004076 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1134454004077 GIY-YIG motif/motif A; other site 1134454004078 active site 1134454004079 catalytic site [active] 1134454004080 putative DNA binding site [nucleotide binding]; other site 1134454004081 metal binding site [ion binding]; metal-binding site 1134454004082 UvrB/uvrC motif; Region: UVR; pfam02151 1134454004083 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1134454004084 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1134454004085 catalytic core [active] 1134454004086 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1134454004087 iron-sulfur cluster [ion binding]; other site 1134454004088 [2Fe-2S] cluster binding site [ion binding]; other site 1134454004089 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1134454004090 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1134454004091 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1134454004092 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1134454004093 mycothiol-dependent maleylpyruvate isomerase; Reviewed; Region: PRK09583 1134454004094 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1134454004095 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1134454004096 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 1134454004097 excinuclease ABC subunit B; Provisional; Region: PRK05298 1134454004098 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1134454004099 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1134454004100 nucleotide binding region [chemical binding]; other site 1134454004101 ATP-binding site [chemical binding]; other site 1134454004102 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1134454004103 UvrB/uvrC motif; Region: UVR; pfam02151 1134454004104 Bacteriocin (Lactococcin_972); Region: Lactococcin_972; cl09891 1134454004105 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1134454004106 Walker A/P-loop; other site 1134454004107 ATP binding site [chemical binding]; other site 1134454004108 Q-loop/lid; other site 1134454004109 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1134454004110 ABC transporter signature motif; other site 1134454004111 Walker B; other site 1134454004112 D-loop; other site 1134454004113 H-loop/switch region; other site 1134454004114 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1134454004115 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1134454004116 intersubunit interface [polypeptide binding]; other site 1134454004117 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1134454004118 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1134454004119 ABC-ATPase subunit interface; other site 1134454004120 dimer interface [polypeptide binding]; other site 1134454004121 putative PBP binding regions; other site 1134454004122 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1134454004123 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1134454004124 Walker A/P-loop; other site 1134454004125 ATP binding site [chemical binding]; other site 1134454004126 Q-loop/lid; other site 1134454004127 ABC transporter signature motif; other site 1134454004128 Walker B; other site 1134454004129 D-loop; other site 1134454004130 H-loop/switch region; other site 1134454004131 Domain of unknown function (DUF3479); Region: DUF3479; pfam11965 1134454004132 CobN/Magnesium Chelatase; Region: CobN-Mg_chel; pfam02514 1134454004133 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1134454004134 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1134454004135 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 1134454004136 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1134454004137 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 1134454004138 metal ion-dependent adhesion site (MIDAS); other site 1134454004139 Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081 1134454004140 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1134454004141 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1134454004142 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1134454004143 CoA-binding site [chemical binding]; other site 1134454004144 ATP-binding [chemical binding]; other site 1134454004145 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1134454004146 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1134454004147 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1134454004148 Walker A/P-loop; other site 1134454004149 ATP binding site [chemical binding]; other site 1134454004150 Q-loop/lid; other site 1134454004151 ABC transporter signature motif; other site 1134454004152 Walker B; other site 1134454004153 D-loop; other site 1134454004154 H-loop/switch region; other site 1134454004155 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 1134454004156 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1134454004157 Walker A/P-loop; other site 1134454004158 ATP binding site [chemical binding]; other site 1134454004159 Q-loop/lid; other site 1134454004160 ABC transporter signature motif; other site 1134454004161 Walker B; other site 1134454004162 D-loop; other site 1134454004163 H-loop/switch region; other site 1134454004164 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1134454004165 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1134454004166 ABC-ATPase subunit interface; other site 1134454004167 dimer interface [polypeptide binding]; other site 1134454004168 putative PBP binding regions; other site 1134454004169 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 1134454004170 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1134454004171 intersubunit interface [polypeptide binding]; other site 1134454004172 Htaa; Region: HtaA; pfam04213 1134454004173 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 1134454004174 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1134454004175 RNA binding site [nucleotide binding]; other site 1134454004176 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1134454004177 RNA binding site [nucleotide binding]; other site 1134454004178 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1134454004179 RNA binding site [nucleotide binding]; other site 1134454004180 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1134454004181 RNA binding site [nucleotide binding]; other site 1134454004182 domain interface; other site 1134454004183 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 1134454004184 active site 1134454004185 putative catalytic site [active] 1134454004186 DNA polymerase I; Provisional; Region: PRK05755 1134454004187 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1134454004188 active site 1134454004189 metal binding site 1 [ion binding]; metal-binding site 1134454004190 putative 5' ssDNA interaction site; other site 1134454004191 metal binding site 3; metal-binding site 1134454004192 metal binding site 2 [ion binding]; metal-binding site 1134454004193 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1134454004194 putative DNA binding site [nucleotide binding]; other site 1134454004195 putative metal binding site [ion binding]; other site 1134454004196 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1134454004197 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1134454004198 active site 1134454004199 DNA binding site [nucleotide binding] 1134454004200 catalytic site [active] 1134454004201 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1134454004202 CoenzymeA binding site [chemical binding]; other site 1134454004203 subunit interaction site [polypeptide binding]; other site 1134454004204 PHB binding site; other site 1134454004205 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 1134454004206 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1134454004207 active site 1134454004208 phosphorylation site [posttranslational modification] 1134454004209 intermolecular recognition site; other site 1134454004210 dimerization interface [polypeptide binding]; other site 1134454004211 ANTAR domain; Region: ANTAR; pfam03861 1134454004212 CrcB-like protein; Region: CRCB; pfam02537 1134454004213 pyruvate kinase; Provisional; Region: PRK06247 1134454004214 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1134454004215 active site 1134454004216 domain interfaces; other site 1134454004217 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1134454004218 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1134454004219 RNA binding surface [nucleotide binding]; other site 1134454004220 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1134454004221 active site 1134454004222 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 1134454004223 lipoprotein signal peptidase; Provisional; Region: PRK14787 1134454004224 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 1134454004225 DivIVA protein; Region: DivIVA; pfam05103 1134454004226 DivIVA domain; Region: DivI1A_domain; TIGR03544 1134454004227 V-type ATP synthase subunit E; Provisional; Region: PRK02292 1134454004228 Protein of unknown function (DUF552); Region: DUF552; pfam04472 1134454004229 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 1134454004230 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 1134454004231 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1134454004232 nucleotide binding site [chemical binding]; other site 1134454004233 SulA interaction site; other site 1134454004234 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1134454004235 Cell division protein FtsQ; Region: FtsQ; pfam03799 1134454004236 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1134454004237 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1134454004238 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1134454004239 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1134454004240 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1134454004241 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1134454004242 active site 1134454004243 homodimer interface [polypeptide binding]; other site 1134454004244 cell division protein FtsW; Region: ftsW; TIGR02614 1134454004245 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438 1134454004246 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1134454004247 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1134454004248 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1134454004249 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1134454004250 Mg++ binding site [ion binding]; other site 1134454004251 putative catalytic motif [active] 1134454004252 putative substrate binding site [chemical binding]; other site 1134454004253 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1134454004254 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1134454004255 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1134454004256 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1134454004257 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1134454004258 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1134454004259 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1134454004260 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1134454004261 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1134454004262 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 1134454004263 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1134454004264 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1134454004265 MraW methylase family; Region: Methyltransf_5; cl17771 1134454004266 cell division protein MraZ; Reviewed; Region: PRK00326 1134454004267 MraZ protein; Region: MraZ; pfam02381 1134454004268 MraZ protein; Region: MraZ; pfam02381 1134454004269 MoxR-like ATPases [General function prediction only]; Region: COG0714 1134454004270 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1134454004271 ATP binding site [chemical binding]; other site 1134454004272 Walker A motif; other site 1134454004273 Walker B motif; other site 1134454004274 arginine finger; other site 1134454004275 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1134454004276 Protein of unknown function DUF58; Region: DUF58; pfam01882 1134454004277 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1134454004278 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1134454004279 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1134454004280 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 1134454004281 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1134454004282 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1134454004283 lipoyl attachment site [posttranslational modification]; other site 1134454004284 glycine dehydrogenase; Provisional; Region: PRK05367 1134454004285 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1134454004286 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1134454004287 catalytic residue [active] 1134454004288 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1134454004289 tetramer interface [polypeptide binding]; other site 1134454004290 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1134454004291 catalytic residue [active] 1134454004292 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1134454004293 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1134454004294 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1134454004295 putative dimer interface [polypeptide binding]; other site 1134454004296 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1134454004297 Part of AAA domain; Region: AAA_19; pfam13245 1134454004298 Family description; Region: UvrD_C_2; pfam13538 1134454004299 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246 1134454004300 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1134454004301 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1134454004302 substrate binding pocket [chemical binding]; other site 1134454004303 chain length determination region; other site 1134454004304 substrate-Mg2+ binding site; other site 1134454004305 catalytic residues [active] 1134454004306 aspartate-rich region 1; other site 1134454004307 active site lid residues [active] 1134454004308 aspartate-rich region 2; other site 1134454004309 Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141 1134454004310 putative RNAase interaction site [polypeptide binding]; other site 1134454004311 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607 1134454004312 active site 1134454004313 barstar interaction site; other site 1134454004314 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1134454004315 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1134454004316 active site 1134454004317 ATP binding site [chemical binding]; other site 1134454004318 substrate binding site [chemical binding]; other site 1134454004319 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1134454004320 substrate binding site [chemical binding]; other site 1134454004321 activation loop (A-loop); other site 1134454004322 activation loop (A-loop); other site 1134454004323 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1134454004324 EamA-like transporter family; Region: EamA; pfam00892 1134454004325 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1134454004326 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1134454004327 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 1134454004328 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 1134454004329 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 1134454004330 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1134454004331 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1134454004332 putative acyl-acceptor binding pocket; other site 1134454004333 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 1134454004334 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1134454004335 nucleotide binding site [chemical binding]; other site 1134454004336 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1134454004337 NlpC/P60 family; Region: NLPC_P60; pfam00877 1134454004338 Rhomboid family; Region: Rhomboid; cl11446 1134454004339 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1134454004340 active site 1134454004341 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 1134454004342 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304 1134454004343 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1134454004344 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1134454004345 active site 1134454004346 phosphorylation site [posttranslational modification] 1134454004347 intermolecular recognition site; other site 1134454004348 dimerization interface [polypeptide binding]; other site 1134454004349 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 1134454004350 Subunit I/III interface [polypeptide binding]; other site 1134454004351 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1134454004352 Cytochrome c; Region: Cytochrom_C; pfam00034 1134454004353 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1134454004354 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1134454004355 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1134454004356 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1134454004357 iron-sulfur cluster [ion binding]; other site 1134454004358 [2Fe-2S] cluster binding site [ion binding]; other site 1134454004359 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1134454004360 heme bH binding site [chemical binding]; other site 1134454004361 intrachain domain interface; other site 1134454004362 heme bL binding site [chemical binding]; other site 1134454004363 interchain domain interface [polypeptide binding]; other site 1134454004364 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 1134454004365 Qo binding site; other site 1134454004366 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1134454004367 active site 1134454004368 DNA binding site [nucleotide binding] 1134454004369 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 1134454004370 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1134454004371 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1134454004372 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1134454004373 phosphate binding site [ion binding]; other site 1134454004374 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1134454004375 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1134454004376 NAD(P) binding site [chemical binding]; other site 1134454004377 putative active site [active] 1134454004378 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1134454004379 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1134454004380 Walker A/P-loop; other site 1134454004381 ATP binding site [chemical binding]; other site 1134454004382 Q-loop/lid; other site 1134454004383 ABC transporter signature motif; other site 1134454004384 Walker B; other site 1134454004385 D-loop; other site 1134454004386 H-loop/switch region; other site 1134454004387 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 1134454004388 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1134454004389 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1134454004390 D-pathway; other site 1134454004391 Putative ubiquinol binding site [chemical binding]; other site 1134454004392 Low-spin heme (heme b) binding site [chemical binding]; other site 1134454004393 Putative water exit pathway; other site 1134454004394 Binuclear center (heme o3/CuB) [ion binding]; other site 1134454004395 K-pathway; other site 1134454004396 Putative proton exit pathway; other site 1134454004397 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 1134454004398 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1134454004399 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 1134454004400 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1134454004401 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 1134454004402 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1134454004403 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1134454004404 interface (dimer of trimers) [polypeptide binding]; other site 1134454004405 Substrate-binding/catalytic site; other site 1134454004406 Zn-binding sites [ion binding]; other site 1134454004407 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1134454004408 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1134454004409 E3 interaction surface; other site 1134454004410 lipoyl attachment site [posttranslational modification]; other site 1134454004411 e3 binding domain; Region: E3_binding; pfam02817 1134454004412 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1134454004413 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1134454004414 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 1134454004415 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1134454004416 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1134454004417 metal-binding site [ion binding] 1134454004418 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1134454004419 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1134454004420 motif II; other site 1134454004421 lipoyl synthase; Provisional; Region: PRK05481 1134454004422 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1134454004423 FeS/SAM binding site; other site 1134454004424 CAMP factor (Cfa); Region: CAMP_factor; pfam07373 1134454004425 putative sialic acid transporter; Provisional; Region: PRK03893 1134454004426 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1134454004427 putative substrate translocation pore; other site 1134454004428 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1134454004429 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 1134454004430 Asp-box motif; other site 1134454004431 catalytic site [active] 1134454004432 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 1134454004433 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 1134454004434 Asp-box motif; other site 1134454004435 catalytic site [active] 1134454004436 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 1134454004437 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 1134454004438 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1134454004439 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1134454004440 ABC transporter; Region: ABC_tran_2; pfam12848 1134454004441 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1134454004442 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 1134454004443 Protein of unknown function (DUF1440); Region: DUF1440; pfam07274 1134454004444 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1134454004445 HPr interaction site; other site 1134454004446 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1134454004447 active site 1134454004448 phosphorylation site [posttranslational modification] 1134454004449 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1134454004450 active site turn [active] 1134454004451 phosphorylation site [posttranslational modification] 1134454004452 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1134454004453 active site turn [active] 1134454004454 phosphorylation site [posttranslational modification] 1134454004455 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1134454004456 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1134454004457 DNA-binding site [nucleotide binding]; DNA binding site 1134454004458 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1134454004459 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1134454004460 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 1134454004461 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1134454004462 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1134454004463 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1134454004464 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 1134454004465 RDD family; Region: RDD; pfam06271 1134454004466 glutamine synthetase, type I; Region: GlnA; TIGR00653 1134454004467 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1134454004468 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1134454004469 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1134454004470 putative active site [active] 1134454004471 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1134454004472 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1134454004473 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1134454004474 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1134454004475 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1134454004476 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 1134454004477 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 1134454004478 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1134454004479 metal binding triad; other site 1134454004480 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1134454004481 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1134454004482 metal binding triad; other site 1134454004483 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1134454004484 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1134454004485 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1134454004486 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1134454004487 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 1134454004488 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1134454004489 active site 1134454004490 carbon starvation protein A; Provisional; Region: PRK15015 1134454004491 Carbon starvation protein CstA; Region: CstA; pfam02554 1134454004492 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1134454004493 Protein of unknown function (DUF466); Region: DUF466; cl01082 1134454004494 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 1134454004495 dimer interface [polypeptide binding]; other site 1134454004496 [2Fe-2S] cluster binding site [ion binding]; other site 1134454004497 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1134454004498 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1134454004499 Walker A/P-loop; other site 1134454004500 ATP binding site [chemical binding]; other site 1134454004501 Q-loop/lid; other site 1134454004502 ABC transporter signature motif; other site 1134454004503 Walker B; other site 1134454004504 D-loop; other site 1134454004505 H-loop/switch region; other site 1134454004506 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1134454004507 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1134454004508 ABC-ATPase subunit interface; other site 1134454004509 dimer interface [polypeptide binding]; other site 1134454004510 putative PBP binding regions; other site 1134454004511 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 1134454004512 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1134454004513 intersubunit interface [polypeptide binding]; other site 1134454004514 YcfA-like protein; Region: YcfA; cl00752 1134454004515 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 1134454004516 Putative zinc ribbon domain; Region: DUF164; pfam02591 1134454004517 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 1134454004518 proline aminopeptidase P II; Provisional; Region: PRK10879 1134454004519 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1134454004520 active site 1134454004521 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1134454004522 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1134454004523 MgtE intracellular N domain; Region: MgtE_N; smart00924 1134454004524 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1134454004525 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 1134454004526 Domain of unknown function DUF59; Region: DUF59; pfam01883 1134454004527 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1134454004528 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1134454004529 Walker A motif; other site 1134454004530 sec-independent translocase; Provisional; Region: PRK01371 1134454004531 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1134454004532 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1134454004533 dimer interface [polypeptide binding]; other site 1134454004534 active site 1134454004535 catalytic residue [active] 1134454004536 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1134454004537 S-adenosylmethionine binding site [chemical binding]; other site 1134454004538 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 1134454004539 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1134454004540 ligand binding site; other site 1134454004541 oligomer interface; other site 1134454004542 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1134454004543 dimer interface [polypeptide binding]; other site 1134454004544 N-terminal domain interface [polypeptide binding]; other site 1134454004545 sulfate 1 binding site; other site 1134454004546 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 1134454004547 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1134454004548 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 1134454004549 DivIVA domain; Region: DivI1A_domain; TIGR03544 1134454004550 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 1134454004551 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 1134454004552 metal binding site [ion binding]; metal-binding site 1134454004553 putative dimer interface [polypeptide binding]; other site 1134454004554 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1134454004555 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1134454004556 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1134454004557 metabolite-proton symporter; Region: 2A0106; TIGR00883 1134454004558 putative substrate translocation pore; other site 1134454004559 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1134454004560 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 1134454004561 Amidinotransferase; Region: Amidinotransf; cl12043 1134454004562 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 1134454004563 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 1134454004564 putative trimer interface [polypeptide binding]; other site 1134454004565 putative CoA binding site [chemical binding]; other site 1134454004566 succinyldiaminopimelate transaminase; Region: DapC_actino; TIGR03539 1134454004567 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1134454004568 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1134454004569 homodimer interface [polypeptide binding]; other site 1134454004570 catalytic residue [active] 1134454004571 Ferredoxin [Energy production and conversion]; Region: COG1146 1134454004572 4Fe-4S binding domain; Region: Fer4; pfam00037 1134454004573 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 1134454004574 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 1134454004575 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 1134454004576 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 1134454004577 ligand binding site [chemical binding]; other site 1134454004578 homodimer interface [polypeptide binding]; other site 1134454004579 NAD(P) binding site [chemical binding]; other site 1134454004580 trimer interface B [polypeptide binding]; other site 1134454004581 trimer interface A [polypeptide binding]; other site 1134454004582 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 1134454004583 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1134454004584 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1134454004585 Coenzyme A binding pocket [chemical binding]; other site 1134454004586 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1134454004587 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 1134454004588 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1134454004589 active site 1134454004590 dihydroxyacetone kinase; Provisional; Region: PRK14479 1134454004591 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 1134454004592 DAK2 domain; Region: Dak2; pfam02734 1134454004593 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1134454004594 L-iditol 2-dehydrogenase; Region: iditol_2_DH_like; cd08235 1134454004595 putative NAD(P) binding site [chemical binding]; other site 1134454004596 catalytic Zn binding site [ion binding]; other site 1134454004597 Proline dehydrogenase; Region: Pro_dh; cl03282 1134454004598 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 1134454004599 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1134454004600 Glutamate binding site [chemical binding]; other site 1134454004601 NAD binding site [chemical binding]; other site 1134454004602 catalytic residues [active] 1134454004603 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1134454004604 Na binding site [ion binding]; other site 1134454004605 Isochorismatase family; Region: Isochorismatase; pfam00857 1134454004606 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1134454004607 catalytic triad [active] 1134454004608 conserved cis-peptide bond; other site 1134454004609 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1134454004610 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1134454004611 intersubunit interface [polypeptide binding]; other site 1134454004612 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1134454004613 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1134454004614 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1134454004615 dimer interface [polypeptide binding]; other site 1134454004616 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1134454004617 putative PBP binding regions; other site 1134454004618 ABC-ATPase subunit interface; other site 1134454004619 FtsX-like permease family; Region: FtsX; pfam02687 1134454004620 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1134454004621 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1134454004622 Walker A/P-loop; other site 1134454004623 ATP binding site [chemical binding]; other site 1134454004624 Q-loop/lid; other site 1134454004625 ABC transporter signature motif; other site 1134454004626 Walker B; other site 1134454004627 D-loop; other site 1134454004628 H-loop/switch region; other site 1134454004629 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 1134454004630 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 1134454004631 substrate binding site [chemical binding]; other site 1134454004632 Mn binding site [ion binding]; other site 1134454004633 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 1134454004634 trimer interface [polypeptide binding]; other site 1134454004635 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1134454004636 Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812 1134454004637 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 1134454004638 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1134454004639 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1134454004640 dimer interface [polypeptide binding]; other site 1134454004641 conserved gate region; other site 1134454004642 putative PBP binding loops; other site 1134454004643 ABC-ATPase subunit interface; other site 1134454004644 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 1134454004645 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1134454004646 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1134454004647 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1134454004648 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1134454004649 DNA binding site [nucleotide binding] 1134454004650 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 1134454004651 ligand binding site [chemical binding]; other site 1134454004652 dimerization interface (open form) [polypeptide binding]; other site 1134454004653 dimerization interface (closed form) [polypeptide binding]; other site 1134454004654 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1134454004655 dimer interface [polypeptide binding]; other site 1134454004656 ABC-ATPase subunit interface; other site 1134454004657 putative PBP binding loops; other site 1134454004658 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1134454004659 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1134454004660 Walker A/P-loop; other site 1134454004661 ATP binding site [chemical binding]; other site 1134454004662 Q-loop/lid; other site 1134454004663 ABC transporter signature motif; other site 1134454004664 Walker B; other site 1134454004665 D-loop; other site 1134454004666 H-loop/switch region; other site 1134454004667 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1134454004668 RNA binding surface [nucleotide binding]; other site 1134454004669 Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496 1134454004670 active site 1134454004671 catalytic triad [active] 1134454004672 membrane ATPase/protein kinase; Provisional; Region: PRK09435 1134454004673 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 1134454004674 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 1134454004675 Walker A; other site 1134454004676 G1 box; other site 1134454004677 GTP/Mg2+ binding site [chemical binding]; other site 1134454004678 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 1134454004679 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 1134454004680 active site 1134454004681 substrate binding site [chemical binding]; other site 1134454004682 coenzyme B12 binding site [chemical binding]; other site 1134454004683 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 1134454004684 B12 binding site [chemical binding]; other site 1134454004685 cobalt ligand [ion binding]; other site 1134454004686 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 1134454004687 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 1134454004688 heterodimer interface [polypeptide binding]; other site 1134454004689 substrate interaction site [chemical binding]; other site 1134454004690 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like; cd11354 1134454004691 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1134454004692 active site 1134454004693 catalytic site [active] 1134454004694 lysine transporter; Provisional; Region: PRK10836 1134454004695 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1134454004696 dimer interface [polypeptide binding]; other site 1134454004697 catalytic triad [active] 1134454004698 peroxidatic and resolving cysteines [active] 1134454004699 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1134454004700 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1134454004701 active site 1134454004702 catalytic tetrad [active] 1134454004703 ACT domain; Region: ACT_6; pfam13740 1134454004704 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 1134454004705 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869 1134454004706 Peptidyl-tRNA hydrolase, type 2 (PTH2)_like . Peptidyl-tRNA hydrolase activity releases tRNA from the premature translation termination product peptidyl-tRNA. Two structurally different enzymes have been reported to encode such activity, Pth present in...; Region: PTH2_family; cl00869 1134454004707 dimer interface [polypeptide binding]; other site 1134454004708 putative active site [active] 1134454004709 arginine repressor; Provisional; Region: PRK03341 1134454004710 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1134454004711 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1134454004712 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 1134454004713 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1134454004714 putative substrate binding site [chemical binding]; other site 1134454004715 nucleotide binding site [chemical binding]; other site 1134454004716 nucleotide binding site [chemical binding]; other site 1134454004717 homodimer interface [polypeptide binding]; other site 1134454004718 ornithine carbamoyltransferase; Validated; Region: PRK02102 1134454004719 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1134454004720 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1134454004721 arginine deiminase; Provisional; Region: PRK01388 1134454004722 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 1134454004723 Spore germination protein; Region: Spore_permease; cl17796 1134454004724 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 1134454004725 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1134454004726 potential catalytic triad [active] 1134454004727 conserved cys residue [active] 1134454004728 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1134454004729 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1134454004730 MarR family; Region: MarR; pfam01047 1134454004731 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1134454004732 putative substrate translocation pore; other site 1134454004733 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1134454004734 GTP-binding protein YchF; Reviewed; Region: PRK09601 1134454004735 YchF GTPase; Region: YchF; cd01900 1134454004736 G1 box; other site 1134454004737 GTP/Mg2+ binding site [chemical binding]; other site 1134454004738 Switch I region; other site 1134454004739 G2 box; other site 1134454004740 Switch II region; other site 1134454004741 G3 box; other site 1134454004742 G4 box; other site 1134454004743 G5 box; other site 1134454004744 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1134454004745 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 1134454004746 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 1134454004747 active site 1134454004748 metal binding site [ion binding]; metal-binding site 1134454004749 RmuC family; Region: RmuC; pfam02646 1134454004750 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1134454004751 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1134454004752 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1134454004753 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1134454004754 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1134454004755 generic binding surface II; other site 1134454004756 generic binding surface I; other site 1134454004757 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1134454004758 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 1134454004759 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 1134454004760 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 1134454004761 putative active site [active] 1134454004762 PhoH-like protein; Region: PhoH; pfam02562 1134454004763 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1134454004764 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1134454004765 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 1134454004766 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 1134454004767 catalytic residue [active] 1134454004768 putative FPP diphosphate binding site; other site 1134454004769 putative FPP binding hydrophobic cleft; other site 1134454004770 dimer interface [polypeptide binding]; other site 1134454004771 putative IPP diphosphate binding site; other site 1134454004772 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 1134454004773 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 1134454004774 catalytic residues [active] 1134454004775 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 1134454004776 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1134454004777 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1134454004778 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1134454004779 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1134454004780 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1134454004781 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1134454004782 ligand binding site [chemical binding]; other site 1134454004783 active site 1134454004784 UGI interface [polypeptide binding]; other site 1134454004785 catalytic site [active] 1134454004786 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 1134454004787 Na2 binding site [ion binding]; other site 1134454004788 putative substrate binding site 1 [chemical binding]; other site 1134454004789 Na binding site 1 [ion binding]; other site 1134454004790 putative substrate binding site 2 [chemical binding]; other site 1134454004791 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 1134454004792 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1134454004793 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1134454004794 active site 1134454004795 catalytic tetrad [active] 1134454004796 Predicted membrane protein [Function unknown]; Region: COG1297 1134454004797 putative oligopeptide transporter, OPT family; Region: TIGR00733 1134454004798 Predicted membrane protein [Function unknown]; Region: COG2246 1134454004799 GtrA-like protein; Region: GtrA; pfam04138 1134454004800 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1134454004801 Coenzyme A binding pocket [chemical binding]; other site 1134454004802 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 1134454004803 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1134454004804 active site 1134454004805 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1134454004806 generic binding surface I; other site 1134454004807 generic binding surface II; other site 1134454004808 DNA Polymerase Y-family; Region: PolY_like; cd03468 1134454004809 active site 1134454004810 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 1134454004811 DNA binding site [nucleotide binding] 1134454004812 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 1134454004813 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 1134454004814 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1134454004815 catalytic triad [active] 1134454004816 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1134454004817 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1134454004818 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 1134454004819 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1134454004820 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1134454004821 catalytic triad [active] 1134454004822 CH-type (Chalaropsis-type) lysozymes represent one of four functionally-defined classes of peptidoglycan hydrolases (also referred to as endo-N-acetylmuramidases) that cleave bacterial cell wall peptidoglycans. CH-type lysozymes exhibit both lysozyme; Region: GH25_CH-type; cd06412 1134454004823 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1134454004824 active site 1134454004825 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 1134454004826 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1134454004827 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1134454004828 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1134454004829 putative active site [active] 1134454004830 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1134454004831 DNA polymerase IV; Provisional; Region: PRK03348 1134454004832 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1134454004833 active site 1134454004834 DNA binding site [nucleotide binding] 1134454004835 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1134454004836 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1134454004837 folate binding site [chemical binding]; other site 1134454004838 NADP+ binding site [chemical binding]; other site 1134454004839 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1134454004840 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1134454004841 dimerization interface [polypeptide binding]; other site 1134454004842 active site 1134454004843 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1134454004844 active site 1134454004845 dimerization interface [polypeptide binding]; other site 1134454004846 ribonuclease PH; Reviewed; Region: rph; PRK00173 1134454004847 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1134454004848 hexamer interface [polypeptide binding]; other site 1134454004849 active site 1134454004850 glutamate racemase; Provisional; Region: PRK00865 1134454004851 FeoA domain; Region: FeoA; pfam04023 1134454004852 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 1134454004853 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1134454004854 G1 box; other site 1134454004855 GTP/Mg2+ binding site [chemical binding]; other site 1134454004856 Switch I region; other site 1134454004857 G2 box; other site 1134454004858 G3 box; other site 1134454004859 Switch II region; other site 1134454004860 G4 box; other site 1134454004861 G5 box; other site 1134454004862 Nucleoside recognition; Region: Gate; pfam07670 1134454004863 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1134454004864 Nucleoside recognition; Region: Gate; pfam07670 1134454004865 NifU-like domain; Region: NifU; cl00484 1134454004866 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1134454004867 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1134454004868 active site 1134454004869 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1134454004870 IHF dimer interface [polypeptide binding]; other site 1134454004871 IHF - DNA interface [nucleotide binding]; other site 1134454004872 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 1134454004873 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 1134454004874 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 1134454004875 RDD family; Region: RDD; pfam06271 1134454004876 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 1134454004877 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1134454004878 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1134454004879 trimer interface [polypeptide binding]; other site 1134454004880 active site 1134454004881 dimer interface [polypeptide binding]; other site 1134454004882 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1134454004883 Cation efflux family; Region: Cation_efflux; pfam01545 1134454004884 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1134454004885 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1134454004886 Trm112p-like protein; Region: Trm112p; cl01066 1134454004887 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 1134454004888 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 1134454004889 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1134454004890 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1134454004891 active site 1134454004892 Transcription factor WhiB; Region: Whib; pfam02467 1134454004893 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1134454004894 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 1134454004895 Substrate binding site; other site 1134454004896 TIGR03089 family protein; Region: TIGR03089 1134454004897 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1134454004898 ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525 1134454004899 Ligand binding site; other site 1134454004900 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 1134454004901 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 1134454004902 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1134454004903 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1134454004904 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1134454004905 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 1134454004906 AIR carboxylase; Region: AIRC; pfam00731 1134454004907 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1134454004908 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1134454004909 NAD binding site [chemical binding]; other site 1134454004910 ATP-grasp domain; Region: ATP-grasp; pfam02222 1134454004911 Bacterial PH domain; Region: DUF304; cl01348 1134454004912 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 1134454004913 active site pocket [active] 1134454004914 oxyanion hole [active] 1134454004915 catalytic triad [active] 1134454004916 active site nucleophile [active] 1134454004917 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1134454004918 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1134454004919 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1134454004920 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1134454004921 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1134454004922 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 1134454004923 Maf-like protein; Region: Maf; pfam02545 1134454004924 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1134454004925 active site 1134454004926 dimer interface [polypeptide binding]; other site 1134454004927 short chain dehydrogenase; Provisional; Region: PRK08219 1134454004928 classical (c) SDRs; Region: SDR_c; cd05233 1134454004929 NAD(P) binding site [chemical binding]; other site 1134454004930 active site 1134454004931 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1134454004932 dimer interface [polypeptide binding]; other site 1134454004933 substrate binding site [chemical binding]; other site 1134454004934 ATP binding site [chemical binding]; other site 1134454004935 TQXA domain; Region: TQXA_dom; TIGR03934 1134454004936 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 1134454004937 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 1134454004938 oligomer interface [polypeptide binding]; other site 1134454004939 metal binding site [ion binding]; metal-binding site 1134454004940 metal binding site [ion binding]; metal-binding site 1134454004941 putative Cl binding site [ion binding]; other site 1134454004942 aspartate ring; other site 1134454004943 basic sphincter; other site 1134454004944 hydrophobic gate; other site 1134454004945 periplasmic entrance; other site 1134454004946 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 1134454004947 nudix motif; other site 1134454004948 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1134454004949 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1134454004950 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1134454004951 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1134454004952 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1134454004953 carboxyltransferase (CT) interaction site; other site 1134454004954 biotinylation site [posttranslational modification]; other site 1134454004955 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 1134454004956 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1134454004957 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1134454004958 purine nucleoside phosphorylase; Provisional; Region: PRK08202 1134454004959 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 1134454004960 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1134454004961 active site 1134454004962 substrate binding site [chemical binding]; other site 1134454004963 metal binding site [ion binding]; metal-binding site 1134454004964 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1134454004965 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1134454004966 acyl-activating enzyme (AAE) consensus motif; other site 1134454004967 AMP binding site [chemical binding]; other site 1134454004968 active site 1134454004969 CoA binding site [chemical binding]; other site 1134454004970 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1134454004971 active site 1134454004972 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1134454004973 putative substrate translocation pore; other site 1134454004974 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 1134454004975 active site 1134454004976 catalytic site [active] 1134454004977 substrate binding site [chemical binding]; other site 1134454004978 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 1134454004979 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1134454004980 active site 1134454004981 HIGH motif; other site 1134454004982 KMSKS motif; other site 1134454004983 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1134454004984 tRNA binding surface [nucleotide binding]; other site 1134454004985 anticodon binding site; other site 1134454004986 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1134454004987 RNA/DNA hybrid binding site [nucleotide binding]; other site 1134454004988 active site 1134454004989 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1134454004990 active site 1134454004991 catalytic motif [active] 1134454004992 Zn binding site [ion binding]; other site 1134454004993 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1134454004994 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1134454004995 TM-ABC transporter signature motif; other site 1134454004996 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1134454004997 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1134454004998 TM-ABC transporter signature motif; other site 1134454004999 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1134454005000 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1134454005001 Walker A/P-loop; other site 1134454005002 ATP binding site [chemical binding]; other site 1134454005003 Q-loop/lid; other site 1134454005004 ABC transporter signature motif; other site 1134454005005 Walker B; other site 1134454005006 D-loop; other site 1134454005007 H-loop/switch region; other site 1134454005008 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1134454005009 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1134454005010 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 1134454005011 ligand binding site [chemical binding]; other site 1134454005012 Phosphotransferase enzyme family; Region: APH; pfam01636 1134454005013 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1134454005014 Domain of unknown function DUF21; Region: DUF21; pfam01595 1134454005015 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1134454005016 Transporter associated domain; Region: CorC_HlyC; smart01091 1134454005017 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 1134454005018 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 1134454005019 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1134454005020 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1134454005021 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 1134454005022 active site 1134454005023 substrate binding site [chemical binding]; other site 1134454005024 cosubstrate binding site; other site 1134454005025 catalytic site [active] 1134454005026 malate dehydrogenase; Provisional; Region: PRK05442 1134454005027 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 1134454005028 NAD(P) binding site [chemical binding]; other site 1134454005029 dimer interface [polypeptide binding]; other site 1134454005030 malate binding site [chemical binding]; other site 1134454005031 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 1134454005032 putative catalytic cysteine [active] 1134454005033 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 1134454005034 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 1134454005035 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1134454005036 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1134454005037 homodimer interface [polypeptide binding]; other site 1134454005038 NADP binding site [chemical binding]; other site 1134454005039 substrate binding site [chemical binding]; other site 1134454005040 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1134454005041 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1134454005042 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1134454005043 purine monophosphate binding site [chemical binding]; other site 1134454005044 dimer interface [polypeptide binding]; other site 1134454005045 putative catalytic residues [active] 1134454005046 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1134454005047 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1134454005048 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1134454005049 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1134454005050 active site 1134454005051 cosubstrate binding site; other site 1134454005052 substrate binding site [chemical binding]; other site 1134454005053 catalytic site [active] 1134454005054 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1134454005055 homopentamer interface [polypeptide binding]; other site 1134454005056 active site 1134454005057 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1134454005058 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1134454005059 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1134454005060 dimerization interface [polypeptide binding]; other site 1134454005061 active site 1134454005062 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1134454005063 Lumazine binding domain; Region: Lum_binding; pfam00677 1134454005064 Lumazine binding domain; Region: Lum_binding; pfam00677 1134454005065 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1134454005066 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1134454005067 catalytic motif [active] 1134454005068 Zn binding site [ion binding]; other site 1134454005069 RibD C-terminal domain; Region: RibD_C; cl17279 1134454005070 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1134454005071 CoA binding domain; Region: CoA_binding; smart00881 1134454005072 CoA-ligase; Region: Ligase_CoA; pfam00549 1134454005073 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1134454005074 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1134454005075 CoA-ligase; Region: Ligase_CoA; pfam00549 1134454005076 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1134454005077 Part of AAA domain; Region: AAA_19; pfam13245 1134454005078 Family description; Region: UvrD_C_2; pfam13538 1134454005079 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1134454005080 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 1134454005081 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1134454005082 Walker A/P-loop; other site 1134454005083 ATP binding site [chemical binding]; other site 1134454005084 Q-loop/lid; other site 1134454005085 ABC transporter signature motif; other site 1134454005086 Walker B; other site 1134454005087 D-loop; other site 1134454005088 H-loop/switch region; other site 1134454005089 NIL domain; Region: NIL; pfam09383 1134454005090 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1134454005091 ABC-ATPase subunit interface; other site 1134454005092 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1134454005093 PLD-like domain; Region: PLDc_2; pfam13091 1134454005094 putative active site [active] 1134454005095 catalytic site [active] 1134454005096 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1134454005097 PLD-like domain; Region: PLDc_2; pfam13091 1134454005098 putative active site [active] 1134454005099 catalytic site [active] 1134454005100 PspC domain; Region: PspC; pfam04024 1134454005101 GMP synthase; Reviewed; Region: guaA; PRK00074 1134454005102 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1134454005103 AMP/PPi binding site [chemical binding]; other site 1134454005104 candidate oxyanion hole; other site 1134454005105 catalytic triad [active] 1134454005106 potential glutamine specificity residues [chemical binding]; other site 1134454005107 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1134454005108 ATP Binding subdomain [chemical binding]; other site 1134454005109 Ligand Binding sites [chemical binding]; other site 1134454005110 Dimerization subdomain; other site 1134454005111 serine O-acetyltransferase; Region: cysE; TIGR01172 1134454005112 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1134454005113 trimer interface [polypeptide binding]; other site 1134454005114 active site 1134454005115 substrate binding site [chemical binding]; other site 1134454005116 CoA binding site [chemical binding]; other site 1134454005117 chorismate mutase; Provisional; Region: PRK09239 1134454005118 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 1134454005119 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1134454005120 phosphate binding site [ion binding]; other site 1134454005121 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1134454005122 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1134454005123 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1134454005124 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1134454005125 active site 1134454005126 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 1134454005127 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 1134454005128 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1134454005129 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1134454005130 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1134454005131 ring oligomerisation interface [polypeptide binding]; other site 1134454005132 ATP/Mg binding site [chemical binding]; other site 1134454005133 stacking interactions; other site 1134454005134 hinge regions; other site 1134454005135 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1134454005136 oligomerisation interface [polypeptide binding]; other site 1134454005137 mobile loop; other site 1134454005138 roof hairpin; other site 1134454005139 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1134454005140 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1134454005141 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1134454005142 Walker A/P-loop; other site 1134454005143 ATP binding site [chemical binding]; other site 1134454005144 Q-loop/lid; other site 1134454005145 ABC transporter signature motif; other site 1134454005146 Walker B; other site 1134454005147 D-loop; other site 1134454005148 H-loop/switch region; other site 1134454005149 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1134454005150 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1134454005151 ABC-ATPase subunit interface; other site 1134454005152 dimer interface [polypeptide binding]; other site 1134454005153 putative PBP binding regions; other site 1134454005154 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 1134454005155 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1134454005156 intersubunit interface [polypeptide binding]; other site 1134454005157 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 1134454005158 putative active site [active] 1134454005159 nucleotide binding site [chemical binding]; other site 1134454005160 nudix motif; other site 1134454005161 putative metal binding site [ion binding]; other site 1134454005162 UGMP family protein; Validated; Region: PRK09604 1134454005163 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 1134454005164 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1134454005165 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1134454005166 Coenzyme A binding pocket [chemical binding]; other site 1134454005167 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1134454005168 Glycoprotease family; Region: Peptidase_M22; pfam00814 1134454005169 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1134454005170 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1134454005171 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1134454005172 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1134454005173 ATP binding site [chemical binding]; other site 1134454005174 Mg++ binding site [ion binding]; other site 1134454005175 motif III; other site 1134454005176 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1134454005177 nucleotide binding region [chemical binding]; other site 1134454005178 ATP-binding site [chemical binding]; other site 1134454005179 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1134454005180 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1134454005181 Walker A/P-loop; other site 1134454005182 ATP binding site [chemical binding]; other site 1134454005183 Q-loop/lid; other site 1134454005184 ABC transporter signature motif; other site 1134454005185 Walker B; other site 1134454005186 D-loop; other site 1134454005187 H-loop/switch region; other site 1134454005188 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1134454005189 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1134454005190 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 1134454005191 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1134454005192 putative substrate binding site [chemical binding]; other site 1134454005193 putative ATP binding site [chemical binding]; other site 1134454005194 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1134454005195 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1134454005196 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1134454005197 glutaminase active site [active] 1134454005198 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1134454005199 dimer interface [polypeptide binding]; other site 1134454005200 active site 1134454005201 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1134454005202 dimer interface [polypeptide binding]; other site 1134454005203 active site 1134454005204 Lipase (class 2); Region: Lipase_2; pfam01674 1134454005205 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1134454005206 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1134454005207 Lipase (class 2); Region: Lipase_2; pfam01674 1134454005208 pantothenate kinase; Provisional; Region: PRK05439 1134454005209 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1134454005210 ATP-binding site [chemical binding]; other site 1134454005211 CoA-binding site [chemical binding]; other site 1134454005212 Mg2+-binding site [ion binding]; other site 1134454005213 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 1134454005214 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1134454005215 active site 1134454005216 substrate binding site [chemical binding]; other site 1134454005217 metal binding site [ion binding]; metal-binding site 1134454005218 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1134454005219 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1134454005220 23S rRNA interface [nucleotide binding]; other site 1134454005221 L3 interface [polypeptide binding]; other site 1134454005222 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1134454005223 S-adenosylmethionine binding site [chemical binding]; other site 1134454005224 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1134454005225 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1134454005226 dimerization interface 3.5A [polypeptide binding]; other site 1134454005227 active site 1134454005228 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1134454005229 S-adenosylmethionine binding site [chemical binding]; other site 1134454005230 Cobalt transport protein; Region: CbiQ; cl00463 1134454005231 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1134454005232 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1134454005233 Walker A/P-loop; other site 1134454005234 ATP binding site [chemical binding]; other site 1134454005235 Q-loop/lid; other site 1134454005236 ABC transporter signature motif; other site 1134454005237 Walker B; other site 1134454005238 D-loop; other site 1134454005239 H-loop/switch region; other site 1134454005240 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1134454005241 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1134454005242 Walker A/P-loop; other site 1134454005243 ATP binding site [chemical binding]; other site 1134454005244 Q-loop/lid; other site 1134454005245 ABC transporter signature motif; other site 1134454005246 Walker B; other site 1134454005247 D-loop; other site 1134454005248 H-loop/switch region; other site 1134454005249 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 1134454005250 classical (c) SDRs; Region: SDR_c; cd05233 1134454005251 NAD(P) binding site [chemical binding]; other site 1134454005252 active site 1134454005253 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 1134454005254 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1134454005255 Walker A/P-loop; other site 1134454005256 ATP binding site [chemical binding]; other site 1134454005257 Q-loop/lid; other site 1134454005258 ABC transporter signature motif; other site 1134454005259 Walker B; other site 1134454005260 D-loop; other site 1134454005261 H-loop/switch region; other site 1134454005262 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1134454005263 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1134454005264 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1134454005265 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1134454005266 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1134454005267 putative substrate translocation pore; other site 1134454005268 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1134454005269 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1134454005270 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1134454005271 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1134454005272 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1134454005273 alphaNTD homodimer interface [polypeptide binding]; other site 1134454005274 alphaNTD - beta interaction site [polypeptide binding]; other site 1134454005275 alphaNTD - beta' interaction site [polypeptide binding]; other site 1134454005276 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1134454005277 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1134454005278 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1134454005279 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1134454005280 RNA binding surface [nucleotide binding]; other site 1134454005281 30S ribosomal protein S11; Validated; Region: PRK05309 1134454005282 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1134454005283 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1134454005284 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 1134454005285 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1134454005286 rRNA binding site [nucleotide binding]; other site 1134454005287 predicted 30S ribosome binding site; other site 1134454005288 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1134454005289 active site 1134454005290 adenylate kinase; Reviewed; Region: adk; PRK00279 1134454005291 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1134454005292 AMP-binding site [chemical binding]; other site 1134454005293 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1134454005294 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1134454005295 SecY translocase; Region: SecY; pfam00344 1134454005296 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1134454005297 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1134454005298 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1134454005299 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 1134454005300 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1134454005301 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1134454005302 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1134454005303 23S rRNA binding site [nucleotide binding]; other site 1134454005304 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1134454005305 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1134454005306 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1134454005307 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1134454005308 23S rRNA interface [nucleotide binding]; other site 1134454005309 5S rRNA interface [nucleotide binding]; other site 1134454005310 L27 interface [polypeptide binding]; other site 1134454005311 L5 interface [polypeptide binding]; other site 1134454005312 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1134454005313 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1134454005314 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1134454005315 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1134454005316 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 1134454005317 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1134454005318 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1134454005319 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1134454005320 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1134454005321 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1134454005322 RNA binding site [nucleotide binding]; other site 1134454005323 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1134454005324 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1134454005325 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1134454005326 23S rRNA interface [nucleotide binding]; other site 1134454005327 putative translocon interaction site; other site 1134454005328 signal recognition particle (SRP54) interaction site; other site 1134454005329 L23 interface [polypeptide binding]; other site 1134454005330 trigger factor interaction site; other site 1134454005331 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1134454005332 23S rRNA interface [nucleotide binding]; other site 1134454005333 5S rRNA interface [nucleotide binding]; other site 1134454005334 putative antibiotic binding site [chemical binding]; other site 1134454005335 L25 interface [polypeptide binding]; other site 1134454005336 L27 interface [polypeptide binding]; other site 1134454005337 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1134454005338 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1134454005339 G-X-X-G motif; other site 1134454005340 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1134454005341 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1134454005342 putative translocon binding site; other site 1134454005343 protein-rRNA interface [nucleotide binding]; other site 1134454005344 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1134454005345 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1134454005346 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1134454005347 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1134454005348 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1134454005349 50S ribosomal protein L4; Provisional; Region: rplD; PRK14547 1134454005350 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1134454005351 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1134454005352 6-carboxyhexanoate--CoA ligase; Region: BioW; pfam03744 1134454005353 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 1134454005354 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1134454005355 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1134454005356 catalytic residue [active] 1134454005357 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1134454005358 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1134454005359 HIGH motif; other site 1134454005360 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1134454005361 active site 1134454005362 KMSKS motif; other site 1134454005363 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 1134454005364 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1134454005365 active site 1134454005366 HIGH motif; other site 1134454005367 nucleotide binding site [chemical binding]; other site 1134454005368 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1134454005369 active site 1134454005370 KMSKS motif; other site 1134454005371 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 1134454005372 2',3'-cyclic-nucleotide 2'-phosphodiesterase; Region: CycNucDiestase; TIGR01390 1134454005373 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 1134454005374 active site 1134454005375 metal binding site [ion binding]; metal-binding site 1134454005376 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1134454005377 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 1134454005378 elongation factor Tu; Reviewed; Region: PRK00049 1134454005379 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1134454005380 G1 box; other site 1134454005381 GEF interaction site [polypeptide binding]; other site 1134454005382 GTP/Mg2+ binding site [chemical binding]; other site 1134454005383 Switch I region; other site 1134454005384 G2 box; other site 1134454005385 G3 box; other site 1134454005386 Switch II region; other site 1134454005387 G4 box; other site 1134454005388 G5 box; other site 1134454005389 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1134454005390 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1134454005391 Antibiotic Binding Site [chemical binding]; other site 1134454005392 elongation factor G; Reviewed; Region: PRK00007 1134454005393 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1134454005394 G1 box; other site 1134454005395 putative GEF interaction site [polypeptide binding]; other site 1134454005396 GTP/Mg2+ binding site [chemical binding]; other site 1134454005397 Switch I region; other site 1134454005398 G2 box; other site 1134454005399 G3 box; other site 1134454005400 Switch II region; other site 1134454005401 G4 box; other site 1134454005402 G5 box; other site 1134454005403 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1134454005404 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1134454005405 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1134454005406 30S ribosomal protein S7; Validated; Region: PRK05302 1134454005407 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1134454005408 S17 interaction site [polypeptide binding]; other site 1134454005409 S8 interaction site; other site 1134454005410 16S rRNA interaction site [nucleotide binding]; other site 1134454005411 streptomycin interaction site [chemical binding]; other site 1134454005412 23S rRNA interaction site [nucleotide binding]; other site 1134454005413 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1134454005414 Filamin/ABP280 repeat; Region: Filamin; pfam00630 1134454005415 putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773 1134454005416 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 1134454005417 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 1134454005418 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1134454005419 DNA-directed RNA polymerase, beta' subunit, predominant form; Region: rpoC_TIGR; TIGR02386 1134454005420 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1134454005421 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1134454005422 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1134454005423 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1134454005424 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 1134454005425 G-loop; other site 1134454005426 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1134454005427 DNA binding site [nucleotide binding] 1134454005428 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1134454005429 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1134454005430 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1134454005431 RPB12 interaction site [polypeptide binding]; other site 1134454005432 RPB1 interaction site [polypeptide binding]; other site 1134454005433 RPB10 interaction site [polypeptide binding]; other site 1134454005434 RPB11 interaction site [polypeptide binding]; other site 1134454005435 RPB3 interaction site [polypeptide binding]; other site 1134454005436 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1134454005437 core dimer interface [polypeptide binding]; other site 1134454005438 peripheral dimer interface [polypeptide binding]; other site 1134454005439 L10 interface [polypeptide binding]; other site 1134454005440 L11 interface [polypeptide binding]; other site 1134454005441 putative EF-Tu interaction site [polypeptide binding]; other site 1134454005442 putative EF-G interaction site [polypeptide binding]; other site 1134454005443 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1134454005444 23S rRNA interface [nucleotide binding]; other site 1134454005445 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1134454005446 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1134454005447 mRNA/rRNA interface [nucleotide binding]; other site 1134454005448 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1134454005449 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1134454005450 23S rRNA interface [nucleotide binding]; other site 1134454005451 putative thiostrepton binding site; other site 1134454005452 L7/L12 interface [polypeptide binding]; other site 1134454005453 L25 interface [polypeptide binding]; other site 1134454005454 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1134454005455 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1134454005456 putative homodimer interface [polypeptide binding]; other site 1134454005457 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1134454005458 heterodimer interface [polypeptide binding]; other site 1134454005459 homodimer interface [polypeptide binding]; other site 1134454005460 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 1134454005461 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 1134454005462 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1134454005463 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1134454005464 homodimer interface [polypeptide binding]; other site 1134454005465 catalytic residue [active] 1134454005466 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 1134454005467 FAD binding domain; Region: FAD_binding_4; pfam01565 1134454005468 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1134454005469 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 1134454005470 active site 1134454005471 catalytic site [active] 1134454005472 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1134454005473 active site 1134454005474 catalytic site [active] 1134454005475 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 1134454005476 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 1134454005477 putative active site [active] 1134454005478 putative catalytic site [active] 1134454005479 putative DNA binding site [nucleotide binding]; other site 1134454005480 putative phosphate binding site [ion binding]; other site 1134454005481 metal binding site A [ion binding]; metal-binding site 1134454005482 putative AP binding site [nucleotide binding]; other site 1134454005483 putative metal binding site B [ion binding]; other site 1134454005484 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1134454005485 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 1134454005486 substrate binding site [chemical binding]; other site 1134454005487 oxyanion hole (OAH) forming residues; other site 1134454005488 trimer interface [polypeptide binding]; other site 1134454005489 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 1134454005490 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 1134454005491 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 1134454005492 4Fe-4S binding domain; Region: Fer4; cl02805 1134454005493 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329 1134454005494 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194 1134454005495 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 1134454005496 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1134454005497 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1134454005498 dimer interface [polypeptide binding]; other site 1134454005499 PYR/PP interface [polypeptide binding]; other site 1134454005500 TPP binding site [chemical binding]; other site 1134454005501 substrate binding site [chemical binding]; other site 1134454005502 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 1134454005503 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 1134454005504 TPP-binding site [chemical binding]; other site 1134454005505 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 1134454005506 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 1134454005507 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 1134454005508 active site 1134454005509 Zn binding site [ion binding]; other site 1134454005510 heme ABC exporter, ATP-binding protein CcmA; Region: ccmA; TIGR01189 1134454005511 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1134454005512 Walker A/P-loop; other site 1134454005513 ATP binding site [chemical binding]; other site 1134454005514 Q-loop/lid; other site 1134454005515 ABC transporter signature motif; other site 1134454005516 Walker B; other site 1134454005517 D-loop; other site 1134454005518 H-loop/switch region; other site 1134454005519 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1134454005520 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1134454005521 Walker A/P-loop; other site 1134454005522 ATP binding site [chemical binding]; other site 1134454005523 Q-loop/lid; other site 1134454005524 ABC transporter signature motif; other site 1134454005525 Walker B; other site 1134454005526 D-loop; other site 1134454005527 H-loop/switch region; other site 1134454005528 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1134454005529 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 1134454005530 active site 1134454005531 SAM binding site [chemical binding]; other site 1134454005532 homodimer interface [polypeptide binding]; other site 1134454005533 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1134454005534 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1134454005535 substrate binding pocket [chemical binding]; other site 1134454005536 chain length determination region; other site 1134454005537 substrate-Mg2+ binding site; other site 1134454005538 catalytic residues [active] 1134454005539 aspartate-rich region 1; other site 1134454005540 active site lid residues [active] 1134454005541 aspartate-rich region 2; other site 1134454005542 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1134454005543 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1134454005544 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1134454005545 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1134454005546 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1134454005547 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1134454005548 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1134454005549 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1134454005550 NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839 1134454005551 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 1134454005552 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 1134454005553 4Fe-4S binding domain; Region: Fer4; pfam00037 1134454005554 4Fe-4S binding domain; Region: Fer4; pfam00037 1134454005555 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1134454005556 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1134454005557 NADH dehydrogenase subunit G; Validated; Region: PRK07860 1134454005558 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1134454005559 catalytic loop [active] 1134454005560 iron binding site [ion binding]; other site 1134454005561 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1134454005562 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 1134454005563 [4Fe-4S] binding site [ion binding]; other site 1134454005564 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 1134454005565 molybdopterin cofactor binding site; other site 1134454005566 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 1134454005567 SLBB domain; Region: SLBB; pfam10531 1134454005568 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 1134454005569 NADH dehydrogenase subunit E; Validated; Region: PRK07539 1134454005570 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1134454005571 putative dimer interface [polypeptide binding]; other site 1134454005572 [2Fe-2S] cluster binding site [ion binding]; other site 1134454005573 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 1134454005574 NADH dehydrogenase subunit D; Validated; Region: PRK06075 1134454005575 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 1134454005576 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 1134454005577 NADH dehydrogenase subunit B; Validated; Region: PRK06411 1134454005578 NADH dehydrogenase subunit A; Validated; Region: PRK07928 1134454005579 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 1134454005580 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1134454005581 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539 1134454005582 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1134454005583 Walker A/P-loop; other site 1134454005584 ATP binding site [chemical binding]; other site 1134454005585 Q-loop/lid; other site 1134454005586 ABC transporter signature motif; other site 1134454005587 Walker B; other site 1134454005588 D-loop; other site 1134454005589 H-loop/switch region; other site 1134454005590 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1134454005591 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1134454005592 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1134454005593 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1134454005594 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1134454005595 Walker A/P-loop; other site 1134454005596 ATP binding site [chemical binding]; other site 1134454005597 Q-loop/lid; other site 1134454005598 ABC transporter signature motif; other site 1134454005599 Walker B; other site 1134454005600 D-loop; other site 1134454005601 H-loop/switch region; other site 1134454005602 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 1134454005603 UbiA prenyltransferase family; Region: UbiA; pfam01040 1134454005604 H+ Antiporter protein; Region: 2A0121; TIGR00900 1134454005605 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1134454005606 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1134454005607 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 1134454005608 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 1134454005609 DAK2 domain; Region: Dak2; cl03685 1134454005610 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 1134454005611 active pocket/dimerization site; other site 1134454005612 active site 1134454005613 phosphorylation site [posttranslational modification] 1134454005614 Deoxycytidylate deaminase [Nucleotide transport and metabolism]; Region: ComEB; COG2131 1134454005615 active site 1134454005616 Zn binding site [ion binding]; other site 1134454005617 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1134454005618 Cation efflux family; Region: Cation_efflux; cl00316 1134454005619 A subgroup of L-lactate dehydrogenases; Region: LDH_3; cd05290 1134454005620 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 1134454005621 NAD binding site [chemical binding]; other site 1134454005622 dimer interface [polypeptide binding]; other site 1134454005623 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1134454005624 substrate binding site [chemical binding]; other site 1134454005625 Patatin-like phospholipase; Region: Patatin; pfam01734 1134454005626 active site 1134454005627 nucleophile elbow; other site 1134454005628 Patatin-like phospholipase; Region: Patatin; pfam01734 1134454005629 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1134454005630 UMP phosphatase; Provisional; Region: PRK10444 1134454005631 active site 1134454005632 motif I; other site 1134454005633 motif II; other site 1134454005634 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1134454005635 Right handed beta helix region; Region: Beta_helix; pfam13229 1134454005636 Right handed beta helix region; Region: Beta_helix; pfam13229 1134454005637 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 1134454005638 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1134454005639 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1134454005640 Domain of unknown function (DUF4091); Region: DUF4091; pfam13320 1134454005641 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1134454005642 dimer interface [polypeptide binding]; other site 1134454005643 conserved gate region; other site 1134454005644 putative PBP binding loops; other site 1134454005645 ABC-ATPase subunit interface; other site 1134454005646 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1134454005647 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1134454005648 dimer interface [polypeptide binding]; other site 1134454005649 conserved gate region; other site 1134454005650 putative PBP binding loops; other site 1134454005651 ABC-ATPase subunit interface; other site 1134454005652 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1134454005653 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1134454005654 Bacterial SH3 domain; Region: SH3_3; pfam08239 1134454005655 Bacterial SH3 domain; Region: SH3_3; cl17532 1134454005656 Bacterial SH3 domain; Region: SH3_3; cl17532 1134454005657 NlpC/P60 family; Region: NLPC_P60; cl17555 1134454005658 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1134454005659 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1134454005660 dimer interface [polypeptide binding]; other site 1134454005661 conserved gate region; other site 1134454005662 putative PBP binding loops; other site 1134454005663 ABC-ATPase subunit interface; other site 1134454005664 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1134454005665 dimer interface [polypeptide binding]; other site 1134454005666 conserved gate region; other site 1134454005667 putative PBP binding loops; other site 1134454005668 ABC-ATPase subunit interface; other site 1134454005669 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1134454005670 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1134454005671 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1134454005672 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 1134454005673 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1134454005674 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1134454005675 dimerization interface [polypeptide binding]; other site 1134454005676 putative ATP binding site [chemical binding]; other site 1134454005677 amidophosphoribosyltransferase; Provisional; Region: PRK07847 1134454005678 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1134454005679 active site 1134454005680 tetramer interface [polypeptide binding]; other site 1134454005681 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1134454005682 active site 1134454005683 hypothetical protein; Provisional; Region: PRK07907 1134454005684 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 1134454005685 active site 1134454005686 metal binding site [ion binding]; metal-binding site 1134454005687 dimer interface [polypeptide binding]; other site 1134454005688 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1134454005689 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1134454005690 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 1134454005691 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1134454005692 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1134454005693 glutamine binding [chemical binding]; other site 1134454005694 catalytic triad [active] 1134454005695 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1134454005696 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 1134454005697 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1134454005698 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1134454005699 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1134454005700 dimerization interface [polypeptide binding]; other site 1134454005701 ATP binding site [chemical binding]; other site 1134454005702 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1134454005703 dimerization interface [polypeptide binding]; other site 1134454005704 ATP binding site [chemical binding]; other site 1134454005705 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1134454005706 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1134454005707 putative substrate translocation pore; other site 1134454005708 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 1134454005709 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 1134454005710 Zn binding site [ion binding]; other site 1134454005711 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 1134454005712 active site 1134454005713 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1134454005714 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1134454005715 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1134454005716 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1134454005717 putative active site [active] 1134454005718 catalytic triad [active] 1134454005719 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 1134454005720 ATP binding site [chemical binding]; other site 1134454005721 active site 1134454005722 substrate binding site [chemical binding]; other site 1134454005723 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 1134454005724 peroxiredoxin; Region: AhpC; TIGR03137 1134454005725 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1134454005726 dimer interface [polypeptide binding]; other site 1134454005727 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1134454005728 catalytic triad [active] 1134454005729 peroxidatic and resolving cysteines [active] 1134454005730 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 1134454005731 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1134454005732 catalytic residue [active] 1134454005733 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 1134454005734 catalytic residues [active] 1134454005735 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1134454005736 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1134454005737 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1134454005738 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1134454005739 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 1134454005740 dimerization interface [polypeptide binding]; other site 1134454005741 adenylosuccinate lyase; Region: purB; TIGR00928 1134454005742 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 1134454005743 tetramer interface [polypeptide binding]; other site 1134454005744 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1134454005745 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1134454005746 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1134454005747 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1134454005748 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1134454005749 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1134454005750 GDP-binding site [chemical binding]; other site 1134454005751 ACT binding site; other site 1134454005752 IMP binding site; other site 1134454005753 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1134454005754 Coenzyme A binding pocket [chemical binding]; other site 1134454005755 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1134454005756 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1134454005757 DNA-binding site [nucleotide binding]; DNA binding site 1134454005758 FCD domain; Region: FCD; pfam07729 1134454005759 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 1134454005760 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 1134454005761 putative active site cavity [active] 1134454005762 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1134454005763 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1134454005764 inhibitor site; inhibition site 1134454005765 active site 1134454005766 dimer interface [polypeptide binding]; other site 1134454005767 catalytic residue [active] 1134454005768 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1134454005769 putative sialic acid transporter; Provisional; Region: PRK03893 1134454005770 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1134454005771 putative substrate translocation pore; other site 1134454005772 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1134454005773 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 1134454005774 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1134454005775 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 1134454005776 G1 box; other site 1134454005777 putative GEF interaction site [polypeptide binding]; other site 1134454005778 GTP/Mg2+ binding site [chemical binding]; other site 1134454005779 Switch I region; other site 1134454005780 G2 box; other site 1134454005781 G3 box; other site 1134454005782 Switch II region; other site 1134454005783 G4 box; other site 1134454005784 G5 box; other site 1134454005785 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1134454005786 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1134454005787 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1134454005788 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1134454005789 carboxyltransferase (CT) interaction site; other site 1134454005790 biotinylation site [posttranslational modification]; other site 1134454005791 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 1134454005792 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1134454005793 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1134454005794 oxaloacetate decarboxylase; Provisional; Region: PRK12330 1134454005795 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1134454005796 active site 1134454005797 catalytic residues [active] 1134454005798 metal binding site [ion binding]; metal-binding site 1134454005799 homodimer binding site [polypeptide binding]; other site 1134454005800 PAS domain; Region: PAS_9; pfam13426 1134454005801 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1134454005802 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 1134454005803 active site 1134454005804 intersubunit interface [polypeptide binding]; other site 1134454005805 zinc binding site [ion binding]; other site 1134454005806 Na+ binding site [ion binding]; other site 1134454005807 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1134454005808 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1134454005809 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1134454005810 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1134454005811 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1134454005812 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1134454005813 SEC-C motif; Region: SEC-C; pfam02810 1134454005814 hypothetical protein; Provisional; Region: PRK04233 1134454005815 benzoate transport; Region: 2A0115; TIGR00895 1134454005816 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1134454005817 putative substrate translocation pore; other site 1134454005818 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1134454005819 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1134454005820 Clp amino terminal domain; Region: Clp_N; pfam02861 1134454005821 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1134454005822 Walker A motif; other site 1134454005823 ATP binding site [chemical binding]; other site 1134454005824 Walker B motif; other site 1134454005825 arginine finger; other site 1134454005826 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1134454005827 Walker A motif; other site 1134454005828 ATP binding site [chemical binding]; other site 1134454005829 Walker B motif; other site 1134454005830 arginine finger; other site 1134454005831 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1134454005832 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 1134454005833 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 1134454005834 Eukaryotic phosphomannomutase; Region: PMM; cl17107 1134454005835 fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377 1134454005836 catalytic residue [active] 1134454005837 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 1134454005838 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 1134454005839 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1134454005840 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1134454005841 Histidine kinase; Region: HisKA_3; pfam07730 1134454005842 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1134454005843 ATP binding site [chemical binding]; other site 1134454005844 Mg2+ binding site [ion binding]; other site 1134454005845 G-X-G motif; other site 1134454005846 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1134454005847 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1134454005848 active site 1134454005849 phosphorylation site [posttranslational modification] 1134454005850 intermolecular recognition site; other site 1134454005851 dimerization interface [polypeptide binding]; other site 1134454005852 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1134454005853 DNA binding residues [nucleotide binding] 1134454005854 dimerization interface [polypeptide binding]; other site 1134454005855 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1134454005856 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1134454005857 Walker A/P-loop; other site 1134454005858 ATP binding site [chemical binding]; other site 1134454005859 Q-loop/lid; other site 1134454005860 ABC transporter signature motif; other site 1134454005861 Walker B; other site 1134454005862 D-loop; other site 1134454005863 H-loop/switch region; other site 1134454005864 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1134454005865 FtsX-like permease family; Region: FtsX; pfam02687 1134454005866 FtsX-like permease family; Region: FtsX; pfam02687 1134454005867 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 1134454005868 nudix motif; other site 1134454005869 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1134454005870 Predicted permease [General function prediction only]; Region: COG2985 1134454005871 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 1134454005872 TrkA-C domain; Region: TrkA_C; pfam02080 1134454005873 TrkA-C domain; Region: TrkA_C; pfam02080 1134454005874 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 1134454005875 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1134454005876 6-hydroxycyclohex-1-ene-1-carboxyl-CoA dehydrogenase, N-benzyl-3-pyrrolidinol dehydrogenase, and other MDR family members; Region: hydroxyacyl_CoA_DH; cd08254 1134454005877 putative NAD(P) binding site [chemical binding]; other site 1134454005878 catalytic Zn binding site [ion binding]; other site 1134454005879 structural Zn binding site [ion binding]; other site 1134454005880 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1134454005881 active site 1134454005882 catalytic triad [active] 1134454005883 oxyanion hole [active] 1134454005884 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 1134454005885 DNA binding residues [nucleotide binding] 1134454005886 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1134454005887 putative dimer interface [polypeptide binding]; other site 1134454005888 chaperone protein DnaJ; Provisional; Region: PRK14295 1134454005889 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1134454005890 HSP70 interaction site [polypeptide binding]; other site 1134454005891 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1134454005892 Zn binding sites [ion binding]; other site 1134454005893 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1134454005894 dimer interface [polypeptide binding]; other site 1134454005895 GrpE; Region: GrpE; pfam01025 1134454005896 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1134454005897 dimer interface [polypeptide binding]; other site 1134454005898 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1134454005899 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1134454005900 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1134454005901 nucleotide binding site [chemical binding]; other site 1134454005902 NEF interaction site [polypeptide binding]; other site 1134454005903 SBD interface [polypeptide binding]; other site 1134454005904 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1134454005905 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1134454005906 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1134454005907 active site 1134454005908 phosphorylation site [posttranslational modification] 1134454005909 intermolecular recognition site; other site 1134454005910 dimerization interface [polypeptide binding]; other site 1134454005911 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1134454005912 DNA binding site [nucleotide binding] 1134454005913 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1134454005914 intersubunit interface [polypeptide binding]; other site 1134454005915 active site 1134454005916 catalytic residue [active] 1134454005917 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1; cd01653 1134454005918 conserved cys residue [active] 1134454005919 FHA domain; Region: FHA; pfam00498 1134454005920 phosphopeptide binding site; other site 1134454005921 pyruvate phosphate dikinase; Provisional; Region: PRK09279 1134454005922 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1134454005923 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1134454005924 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1134454005925 PEP synthetase regulatory protein; Provisional; Region: PRK05339 1134454005926 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 1134454005927 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1134454005928 S-adenosylmethionine binding site [chemical binding]; other site 1134454005929 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1134454005930 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1134454005931 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 1134454005932 active site 1134454005933 catalytic residues [active] 1134454005934 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 1134454005935 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 1134454005936 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1134454005937 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 1134454005938 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 1134454005939 putative active site [active] 1134454005940 homotetrameric interface [polypeptide binding]; other site 1134454005941 metal binding site [ion binding]; metal-binding site 1134454005942 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 1134454005943 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 1134454005944 active site 1134454005945 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 1134454005946 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1134454005947 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1134454005948 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1134454005949 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1134454005950 Walker A/P-loop; other site 1134454005951 ATP binding site [chemical binding]; other site 1134454005952 Q-loop/lid; other site 1134454005953 ABC transporter signature motif; other site 1134454005954 Walker B; other site 1134454005955 D-loop; other site 1134454005956 H-loop/switch region; other site 1134454005957 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1134454005958 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1134454005959 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1134454005960 Walker A/P-loop; other site 1134454005961 ATP binding site [chemical binding]; other site 1134454005962 Q-loop/lid; other site 1134454005963 ABC transporter signature motif; other site 1134454005964 Walker B; other site 1134454005965 D-loop; other site 1134454005966 H-loop/switch region; other site 1134454005967 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; cl09823 1134454005968 EcsC protein family; Region: EcsC; pfam12787 1134454005969 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1134454005970 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1134454005971 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1134454005972 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 1134454005973 Walker A/P-loop; other site 1134454005974 ATP binding site [chemical binding]; other site 1134454005975 Q-loop/lid; other site 1134454005976 ABC transporter signature motif; other site 1134454005977 Walker B; other site 1134454005978 D-loop; other site 1134454005979 H-loop/switch region; other site 1134454005980 pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349 1134454005981 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1134454005982 E3 interaction surface; other site 1134454005983 lipoyl attachment site [posttranslational modification]; other site 1134454005984 e3 binding domain; Region: E3_binding; pfam02817 1134454005985 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1134454005986 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1134454005987 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1134454005988 alpha subunit interface [polypeptide binding]; other site 1134454005989 TPP binding site [chemical binding]; other site 1134454005990 heterodimer interface [polypeptide binding]; other site 1134454005991 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1134454005992 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1134454005993 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1134454005994 TPP-binding site [chemical binding]; other site 1134454005995 tetramer interface [polypeptide binding]; other site 1134454005996 heterodimer interface [polypeptide binding]; other site 1134454005997 phosphorylation loop region [posttranslational modification] 1134454005998 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1134454005999 radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053 1134454006000 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1134454006001 FeS/SAM binding site; other site 1134454006002 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1134454006003 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1134454006004 H-loop/switch region; other site 1134454006005 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1134454006006 WYL domain; Region: WYL; pfam13280 1134454006007 Integrase core domain; Region: rve_3; pfam13683 1134454006008 Lipase (class 2); Region: Lipase_2; pfam01674 1134454006009 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 1134454006010 CAMP factor (Cfa); Region: CAMP_factor; pfam07373 1134454006011 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1134454006012 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1134454006013 active site 1134454006014 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 1134454006015 proposed catalytic triad [active] 1134454006016 active site nucleophile [active] 1134454006017 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1134454006018 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1134454006019 active site 1134454006020 phosphorylation site [posttranslational modification] 1134454006021 intermolecular recognition site; other site 1134454006022 dimerization interface [polypeptide binding]; other site 1134454006023 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1134454006024 DNA binding site [nucleotide binding] 1134454006025 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1134454006026 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1134454006027 dimerization interface [polypeptide binding]; other site 1134454006028 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1134454006029 dimer interface [polypeptide binding]; other site 1134454006030 phosphorylation site [posttranslational modification] 1134454006031 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1134454006032 ATP binding site [chemical binding]; other site 1134454006033 Mg2+ binding site [ion binding]; other site 1134454006034 G-X-G motif; other site 1134454006035 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 1134454006036 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 1134454006037 active site 1134454006038 metal binding site [ion binding]; metal-binding site 1134454006039 nudix motif; other site 1134454006040 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1134454006041 YCII-related domain; Region: YCII; cl00999 1134454006042 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1134454006043 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 1134454006044 active site 1134454006045 FMN binding site [chemical binding]; other site 1134454006046 substrate binding site [chemical binding]; other site 1134454006047 homotetramer interface [polypeptide binding]; other site 1134454006048 catalytic residue [active] 1134454006049 metabolite-proton symporter; Region: 2A0106; TIGR00883 1134454006050 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1134454006051 putative substrate translocation pore; other site 1134454006052 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK06539 1134454006053 ATP cone domain; Region: ATP-cone; pfam03477 1134454006054 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1134454006055 active site 1134454006056 dimer interface [polypeptide binding]; other site 1134454006057 catalytic residues [active] 1134454006058 effector binding site; other site 1134454006059 R2 peptide binding site; other site 1134454006060 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1134454006061 dimer interface [polypeptide binding]; other site 1134454006062 putative radical transfer pathway; other site 1134454006063 diiron center [ion binding]; other site 1134454006064 tyrosyl radical; other site 1134454006065 Bacterial PH domain; Region: DUF304; pfam03703 1134454006066 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1134454006067 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1134454006068 nucleotide binding site [chemical binding]; other site 1134454006069 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 1134454006070 ornithine carbamoyltransferase; Validated; Region: PRK02102 1134454006071 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 1134454006072 arginine-tRNA ligase; Region: PLN02286 1134454006073 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1134454006074 active site 1134454006075 HIGH motif; other site 1134454006076 KMSK motif region; other site 1134454006077 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1134454006078 tRNA binding surface [nucleotide binding]; other site 1134454006079 anticodon binding site; other site 1134454006080 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1134454006081 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1134454006082 active site 1134454006083 catalytic tetrad [active] 1134454006084 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1134454006085 putative active site [active] 1134454006086 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1134454006087 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1134454006088 active site 1134454006089 dimer interface [polypeptide binding]; other site 1134454006090 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1134454006091 dimer interface [polypeptide binding]; other site 1134454006092 active site 1134454006093 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1134454006094 active site 1134454006095 intersubunit interface [polypeptide binding]; other site 1134454006096 catalytic residue [active] 1134454006097 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1134454006098 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1134454006099 dimerization interface [polypeptide binding]; other site 1134454006100 DPS ferroxidase diiron center [ion binding]; other site 1134454006101 ion pore; other site 1134454006102 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1134454006103 ATP binding site [chemical binding]; other site 1134454006104 putative Mg++ binding site [ion binding]; other site 1134454006105 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1134454006106 nucleotide binding region [chemical binding]; other site 1134454006107 ATP-binding site [chemical binding]; other site 1134454006108 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 1134454006109 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 1134454006110 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1134454006111 FeS/SAM binding site; other site 1134454006112 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK07111 1134454006113 ATP cone domain; Region: ATP-cone; pfam03477 1134454006114 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1134454006115 Class III ribonucleotide reductase; Region: RNR_III; cd01675 1134454006116 active site 1134454006117 Zn binding site [ion binding]; other site 1134454006118 glycine loop; other site 1134454006119 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1134454006120 substrate binding site [chemical binding]; other site 1134454006121 Cutinase; Region: Cutinase; pfam01083 1134454006122 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1134454006123 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1134454006124 NodB motif; other site 1134454006125 active site 1134454006126 catalytic site [active] 1134454006127 metal binding site [ion binding]; metal-binding site 1134454006128 TIGR03943 family protein; Region: TIGR03943 1134454006129 Predicted permease; Region: DUF318; cl17795 1134454006130 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1134454006131 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1134454006132 NodB motif; other site 1134454006133 active site 1134454006134 catalytic site [active] 1134454006135 metal binding site [ion binding]; metal-binding site 1134454006136 integral membrane protein MviN; Region: mviN; TIGR01695 1134454006137 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1134454006138 aspartate kinase; Reviewed; Region: PRK06635 1134454006139 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1134454006140 putative nucleotide binding site [chemical binding]; other site 1134454006141 putative catalytic residues [active] 1134454006142 putative Mg ion binding site [ion binding]; other site 1134454006143 putative aspartate binding site [chemical binding]; other site 1134454006144 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1134454006145 putative allosteric regulatory site; other site 1134454006146 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1134454006147 putative allosteric regulatory residue; other site 1134454006148 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1134454006149 Transglycosylase; Region: Transgly; pfam00912 1134454006150 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1134454006151 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 1134454006152 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1134454006153 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1134454006154 putative active site [active] 1134454006155 putative metal binding site [ion binding]; other site 1134454006156 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1134454006157 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1134454006158 proposed catalytic triad [active] 1134454006159 conserved cys residue [active] 1134454006160 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1134454006161 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1134454006162 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1134454006163 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1134454006164 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1134454006165 ABC-ATPase subunit interface; other site 1134454006166 putative PBP binding loops; other site 1134454006167 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1134454006168 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1134454006169 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1134454006170 dimer interface [polypeptide binding]; other site 1134454006171 conserved gate region; other site 1134454006172 putative PBP binding loops; other site 1134454006173 ABC-ATPase subunit interface; other site 1134454006174 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1134454006175 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1134454006176 Walker A/P-loop; other site 1134454006177 ATP binding site [chemical binding]; other site 1134454006178 Q-loop/lid; other site 1134454006179 ABC transporter signature motif; other site 1134454006180 Walker B; other site 1134454006181 D-loop; other site 1134454006182 H-loop/switch region; other site 1134454006183 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1134454006184 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1134454006185 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1134454006186 Walker A/P-loop; other site 1134454006187 ATP binding site [chemical binding]; other site 1134454006188 Q-loop/lid; other site 1134454006189 ABC transporter signature motif; other site 1134454006190 Walker B; other site 1134454006191 D-loop; other site 1134454006192 H-loop/switch region; other site 1134454006193 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1134454006194 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1134454006195 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1134454006196 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1134454006197 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1134454006198 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1134454006199 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1134454006200 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1134454006201 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1134454006202 urocanate hydratase; Provisional; Region: PRK05414 1134454006203 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1134454006204 allantoate amidohydrolase; Reviewed; Region: PRK09290 1134454006205 active site 1134454006206 metal binding site [ion binding]; metal-binding site 1134454006207 dimer interface [polypeptide binding]; other site 1134454006208 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 1134454006209 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1134454006210 active site 1134454006211 imidazolonepropionase; Provisional; Region: PRK14085 1134454006212 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 1134454006213 active site 1134454006214 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1134454006215 active sites [active] 1134454006216 tetramer interface [polypeptide binding]; other site 1134454006217 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 1134454006218 NAD-dependent deacetylase; Provisional; Region: PRK00481 1134454006219 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 1134454006220 NAD+ binding site [chemical binding]; other site 1134454006221 substrate binding site [chemical binding]; other site 1134454006222 Zn binding site [ion binding]; other site 1134454006223 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1134454006224 Bacterial SH3 domain; Region: SH3_3; pfam08239 1134454006225 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1134454006226 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1134454006227 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 1134454006228 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1134454006229 potassium/proton antiporter; Reviewed; Region: PRK05326 1134454006230 TrkA-C domain; Region: TrkA_C; pfam02080 1134454006231 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1134454006232 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1134454006233 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1134454006234 nucleoside/Zn binding site; other site 1134454006235 dimer interface [polypeptide binding]; other site 1134454006236 catalytic motif [active] 1134454006237 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 1134454006238 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1134454006239 active site 1134454006240 Uncharacterized conserved protein [Function unknown]; Region: COG3777 1134454006241 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1134454006242 active site 1134454006243 catalytic site [active] 1134454006244 PA2301 is an uncharacterized Pseudomonas aeruginosa protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's...; Region: PA2301; cd04939 1134454006245 putative deacylase active site [active] 1134454006246 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1134454006247 K+ potassium transporter; Region: K_trans; pfam02705 1134454006248 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1134454006249 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1134454006250 catalytic triad [active] 1134454006251 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1134454006252 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1134454006253 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1134454006254 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1134454006255 DNA binding site [nucleotide binding] 1134454006256 domain linker motif; other site 1134454006257 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 1134454006258 ligand binding site [chemical binding]; other site 1134454006259 dimerization interface (open form) [polypeptide binding]; other site 1134454006260 dimerization interface (closed form) [polypeptide binding]; other site 1134454006261 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1134454006262 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 1134454006263 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u2; cd11478 1134454006264 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1134454006265 Na binding site [ion binding]; other site 1134454006266 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1134454006267 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 1134454006268 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 1134454006269 NAD(P) binding site [chemical binding]; other site 1134454006270 argininosuccinate synthase; Validated; Region: PRK05370 1134454006271 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1134454006272 putative substrate translocation pore; other site 1134454006273 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1134454006274 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1134454006275 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1134454006276 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1134454006277 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1134454006278 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1134454006279 active site 1134454006280 motif I; other site 1134454006281 motif II; other site 1134454006282 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1134454006283 thiazolylpeptide-type bacteriocin precursor; Region: thiopep_precurs; TIGR03892 1134454006284 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1134454006285 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1134454006286 Walker A/P-loop; other site 1134454006287 ATP binding site [chemical binding]; other site 1134454006288 Q-loop/lid; other site 1134454006289 ABC transporter signature motif; other site 1134454006290 Walker B; other site 1134454006291 D-loop; other site 1134454006292 H-loop/switch region; other site 1134454006293 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1134454006294 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1134454006295 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1134454006296 non-specific DNA binding site [nucleotide binding]; other site 1134454006297 salt bridge; other site 1134454006298 sequence-specific DNA binding site [nucleotide binding]; other site 1134454006299 Cupin domain; Region: Cupin_2; pfam07883 1134454006300 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 1134454006301 B3/4 domain; Region: B3_4; pfam03483 1134454006302 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1134454006303 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1134454006304 Na binding site [ion binding]; other site 1134454006305 oxidoreductase; Provisional; Region: PRK10015 1134454006306 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1134454006307 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1134454006308 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1134454006309 Ligand binding site [chemical binding]; other site 1134454006310 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1134454006311 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1134454006312 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1134454006313 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1134454006314 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1134454006315 active site 1134454006316 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1134454006317 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1134454006318 Bacterial transcriptional regulator; Region: IclR; pfam01614 1134454006319 seryl-tRNA synthetase; Provisional; Region: PRK05431 1134454006320 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1134454006321 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1134454006322 dimer interface [polypeptide binding]; other site 1134454006323 active site 1134454006324 motif 1; other site 1134454006325 motif 2; other site 1134454006326 motif 3; other site 1134454006327 PRC-barrel domain; Region: PRC; pfam05239 1134454006328 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 1134454006329 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1134454006330 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 1134454006331 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1134454006332 phosphate binding motif [ion binding]; other site 1134454006333 Siderophore-interacting protein; Region: SIP; pfam04954 1134454006334 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 1134454006335 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1134454006336 Ferritin-like domain; Region: Ferritin; pfam00210 1134454006337 ferroxidase diiron center [ion binding]; other site 1134454006338 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1134454006339 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1134454006340 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1134454006341 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1134454006342 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1134454006343 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1134454006344 dimer interface [polypeptide binding]; other site 1134454006345 ssDNA binding site [nucleotide binding]; other site 1134454006346 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1134454006347 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1134454006348 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1134454006349 active site 1134454006350 phosphorylation site [posttranslational modification] 1134454006351 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 1134454006352 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1134454006353 active site 1134454006354 P-loop; other site 1134454006355 phosphorylation site [posttranslational modification] 1134454006356 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1134454006357 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1134454006358 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1134454006359 acyl-activating enzyme (AAE) consensus motif; other site 1134454006360 putative AMP binding site [chemical binding]; other site 1134454006361 putative active site [active] 1134454006362 putative CoA binding site [chemical binding]; other site 1134454006363 endonuclease IV; Provisional; Region: PRK01060 1134454006364 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1134454006365 AP (apurinic/apyrimidinic) site pocket; other site 1134454006366 DNA interaction; other site 1134454006367 Metal-binding active site; metal-binding site 1134454006368 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1134454006369 classical (c) SDRs; Region: SDR_c; cd05233 1134454006370 NAD(P) binding site [chemical binding]; other site 1134454006371 active site 1134454006372 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1134454006373 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1134454006374 putative acyl-acceptor binding pocket; other site 1134454006375 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 1134454006376 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1134454006377 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1134454006378 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1134454006379 G5 domain; Region: G5; pfam07501 1134454006380 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1134454006381 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1134454006382 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1134454006383 metal-binding site [ion binding] 1134454006384 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1134454006385 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1134454006386 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1134454006387 metal-binding site [ion binding] 1134454006388 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 1134454006389 putative homodimer interface [polypeptide binding]; other site 1134454006390 putative homotetramer interface [polypeptide binding]; other site 1134454006391 putative allosteric switch controlling residues; other site 1134454006392 putative metal binding site [ion binding]; other site 1134454006393 putative homodimer-homodimer interface [polypeptide binding]; other site 1134454006394 replicative DNA helicase; Region: DnaB; TIGR00665 1134454006395 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1134454006396 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1134454006397 Walker A motif; other site 1134454006398 ATP binding site [chemical binding]; other site 1134454006399 Walker B motif; other site 1134454006400 DNA binding loops [nucleotide binding] 1134454006401 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 1134454006402 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 1134454006403 putative NAD(P) binding site [chemical binding]; other site 1134454006404 dimer interface [polypeptide binding]; other site 1134454006405 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1134454006406 active site 1134454006407 DNA binding site [nucleotide binding] 1134454006408 sn-glycerol-3-phosphate dehydrogenase subunit C; Provisional; Region: glpC; PRK11168 1134454006409 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 1134454006410 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1134454006411 glycerol-3-phosphate dehydrogenase, anaerobic, A subunit; Region: glycerol3P_GlpA; TIGR03377 1134454006412 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1134454006413 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1134454006414 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1134454006415 dimerization interface [polypeptide binding]; other site 1134454006416 ligand binding site [chemical binding]; other site 1134454006417 NADP binding site [chemical binding]; other site 1134454006418 catalytic site [active] 1134454006419 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1134454006420 MarR family; Region: MarR_2; cl17246 1134454006421 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 1134454006422 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1134454006423 Cl- selectivity filter; other site 1134454006424 Cl- binding residues [ion binding]; other site 1134454006425 pore gating glutamate residue; other site 1134454006426 dimer interface [polypeptide binding]; other site 1134454006427 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1134454006428 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1134454006429 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1134454006430 active site 1134454006431 metal binding site [ion binding]; metal-binding site 1134454006432 DNA binding site [nucleotide binding] 1134454006433 Predicted ATPases [General function prediction only]; Region: COG1106 1134454006434 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1134454006435 Uncharacterized conserved protein [Function unknown]; Region: COG4717 1134454006436 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1134454006437 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 1134454006438 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1134454006439 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1134454006440 WHG domain; Region: WHG; pfam13305 1134454006441 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1134454006442 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1134454006443 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1134454006444 catalytic residue [active] 1134454006445 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1134454006446 putative deacylase active site [active] 1134454006447 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1134454006448 NAD synthetase; Reviewed; Region: nadE; PRK02628 1134454006449 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 1134454006450 multimer interface [polypeptide binding]; other site 1134454006451 active site 1134454006452 catalytic triad [active] 1134454006453 protein interface 1 [polypeptide binding]; other site 1134454006454 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1134454006455 homodimer interface [polypeptide binding]; other site 1134454006456 NAD binding pocket [chemical binding]; other site 1134454006457 ATP binding pocket [chemical binding]; other site 1134454006458 Mg binding site [ion binding]; other site 1134454006459 active-site loop [active] 1134454006460 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 1134454006461 6-phosphofructokinase, eukaryotic type; Region: 6PF1K_euk; TIGR02478 1134454006462 active site 1134454006463 ADP/pyrophosphate binding site [chemical binding]; other site 1134454006464 dimerization interface [polypeptide binding]; other site 1134454006465 allosteric effector site; other site 1134454006466 fructose-1,6-bisphosphate binding site; other site 1134454006467 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1134454006468 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1134454006469 hexamer interface [polypeptide binding]; other site 1134454006470 ligand binding site [chemical binding]; other site 1134454006471 putative active site [active] 1134454006472 NAD(P) binding site [chemical binding]; other site 1134454006473 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 1134454006474 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 1134454006475 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1134454006476 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1134454006477 Bacterial SH3 domain; Region: SH3_3; pfam08239 1134454006478 Bacterial SH3 domain; Region: SH3_3; pfam08239 1134454006479 Bacterial SH3 domain; Region: SH3_4; pfam06347 1134454006480 Bacterial SH3 domain; Region: SH3_4; pfam06347 1134454006481 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 1134454006482 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1134454006483 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1134454006484 dimer interface [polypeptide binding]; other site 1134454006485 Citrate synthase; Region: Citrate_synt; pfam00285 1134454006486 active site 1134454006487 citrylCoA binding site [chemical binding]; other site 1134454006488 NADH binding [chemical binding]; other site 1134454006489 cationic pore residues; other site 1134454006490 oxalacetate/citrate binding site [chemical binding]; other site 1134454006491 coenzyme A binding site [chemical binding]; other site 1134454006492 catalytic triad [active] 1134454006493 adenosine deaminase; Provisional; Region: PRK09358 1134454006494 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1134454006495 active site 1134454006496 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1134454006497 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1134454006498 hexamer interface [polypeptide binding]; other site 1134454006499 ligand binding site [chemical binding]; other site 1134454006500 putative active site [active] 1134454006501 NAD(P) binding site [chemical binding]; other site 1134454006502 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1134454006503 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1134454006504 AsnC family; Region: AsnC_trans_reg; pfam01037 1134454006505 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1134454006506 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1134454006507 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1134454006508 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1134454006509 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1134454006510 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 1134454006511 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1134454006512 catalytic residue [active] 1134454006513 D-Lysine 5,6-aminomutase alpha subunit; Region: Lys-AminoMut_A; pfam09043 1134454006514 MutL protein; Region: MutL; pfam13941 1134454006515 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 1134454006516 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815 1134454006517 active site 1134454006518 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1134454006519 dimer interface [polypeptide binding]; other site 1134454006520 substrate binding site [chemical binding]; other site 1134454006521 catalytic residue [active] 1134454006522 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 1134454006523 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 1134454006524 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 1134454006525 alanine racemase; Reviewed; Region: alr; PRK00053 1134454006526 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1134454006527 active site 1134454006528 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1134454006529 dimer interface [polypeptide binding]; other site 1134454006530 substrate binding site [chemical binding]; other site 1134454006531 catalytic residues [active] 1134454006532 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1134454006533 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 1134454006534 active site 1134454006535 substrate binding site [chemical binding]; other site 1134454006536 metal binding site [ion binding]; metal-binding site 1134454006537 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1134454006538 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 1134454006539 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1134454006540 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 1134454006541 active site 1134454006542 Substrate binding site; other site 1134454006543 Mg++ binding site; other site 1134454006544 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1134454006545 putative active site [active] 1134454006546 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1134454006547 Class II fumarases; Region: Fumarase_classII; cd01362 1134454006548 active site 1134454006549 tetramer interface [polypeptide binding]; other site 1134454006550 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1134454006551 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1134454006552 dimer interface [polypeptide binding]; other site 1134454006553 conserved gate region; other site 1134454006554 putative PBP binding loops; other site 1134454006555 ABC-ATPase subunit interface; other site 1134454006556 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1134454006557 dimer interface [polypeptide binding]; other site 1134454006558 conserved gate region; other site 1134454006559 putative PBP binding loops; other site 1134454006560 ABC-ATPase subunit interface; other site 1134454006561 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1134454006562 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1134454006563 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1134454006564 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1134454006565 DNA binding site [nucleotide binding] 1134454006566 domain linker motif; other site 1134454006567 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 1134454006568 putative dimerization interface [polypeptide binding]; other site 1134454006569 putative ligand binding site [chemical binding]; other site 1134454006570 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 1134454006571 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1134454006572 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1134454006573 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1134454006574 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 1134454006575 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1134454006576 active site 1134454006577 NTP binding site [chemical binding]; other site 1134454006578 metal binding triad [ion binding]; metal-binding site 1134454006579 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1134454006580 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1134454006581 Zn2+ binding site [ion binding]; other site 1134454006582 Mg2+ binding site [ion binding]; other site 1134454006583 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1134454006584 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1134454006585 ATP binding site [chemical binding]; other site 1134454006586 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1134454006587 glycerol kinase; Provisional; Region: glpK; PRK00047 1134454006588 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 1134454006589 N- and C-terminal domain interface [polypeptide binding]; other site 1134454006590 active site 1134454006591 MgATP binding site [chemical binding]; other site 1134454006592 catalytic site [active] 1134454006593 metal binding site [ion binding]; metal-binding site 1134454006594 putative homotetramer interface [polypeptide binding]; other site 1134454006595 glycerol binding site [chemical binding]; other site 1134454006596 homodimer interface [polypeptide binding]; other site 1134454006597 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 1134454006598 amphipathic channel; other site 1134454006599 Asn-Pro-Ala signature motifs; other site 1134454006600 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1134454006601 Helix-turn-helix domain; Region: HTH_28; pfam13518 1134454006602 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1134454006603 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1134454006604 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1134454006605 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 1134454006606 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1134454006607 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1134454006608 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1134454006609 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 1134454006610 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1134454006611 probable active site [active] 1134454006612 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1134454006613 putative substrate translocation pore; other site 1134454006614 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1134454006615 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1134454006616 substrate binding pocket [chemical binding]; other site 1134454006617 OsmC-like protein; Region: OsmC; pfam02566 1134454006618 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1134454006619 catalytic residues [active] 1134454006620 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1134454006621 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1134454006622 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1134454006623 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1134454006624 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1134454006625 TPP-binding site [chemical binding]; other site 1134454006626 dimer interface [polypeptide binding]; other site 1134454006627 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1134454006628 PYR/PP interface [polypeptide binding]; other site 1134454006629 dimer interface [polypeptide binding]; other site 1134454006630 TPP binding site [chemical binding]; other site 1134454006631 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1134454006632 ribulokinase; Provisional; Region: PRK04123 1134454006633 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 1134454006634 N- and C-terminal domain interface [polypeptide binding]; other site 1134454006635 active site 1134454006636 MgATP binding site [chemical binding]; other site 1134454006637 catalytic site [active] 1134454006638 metal binding site [ion binding]; metal-binding site 1134454006639 carbohydrate binding site [chemical binding]; other site 1134454006640 homodimer interface [polypeptide binding]; other site 1134454006641 Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175 1134454006642 active site 1134454006643 metal binding site [ion binding]; metal-binding site 1134454006644 Carbohydrate kinase and ribulose-phosphate 3-epimerase fusion proteins-like; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CarbK-RPE_like; cd07783 1134454006645 Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069 1134454006646 N- and C-terminal domain interface [polypeptide binding]; other site 1134454006647 active site 1134454006648 MgATP binding site [chemical binding]; other site 1134454006649 catalytic site [active] 1134454006650 metal binding site [ion binding]; metal-binding site 1134454006651 putative carbohydrate binding site [chemical binding]; other site 1134454006652 putative homodimer interface [polypeptide binding]; other site 1134454006653 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1134454006654 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1134454006655 active site 1134454006656 motif I; other site 1134454006657 motif II; other site 1134454006658 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1134454006659 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 1134454006660 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 1134454006661 active site 1134454006662 Zn2+ binding site [ion binding]; other site 1134454006663 intersubunit interface [polypeptide binding]; other site 1134454006664 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1134454006665 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1134454006666 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1134454006667 mannonate dehydratase; Provisional; Region: PRK03906 1134454006668 mannonate dehydratase; Region: uxuA; TIGR00695 1134454006669 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1134454006670 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1134454006671 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1134454006672 glucuronate isomerase; Reviewed; Region: PRK02925 1134454006673 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 1134454006674 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1134454006675 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1134454006676 DNA binding site [nucleotide binding] 1134454006677 domain linker motif; other site 1134454006678 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1134454006679 dimerization interface [polypeptide binding]; other site 1134454006680 ligand binding site [chemical binding]; other site 1134454006681 MFS/sugar transport protein; Region: MFS_2; pfam13347 1134454006682 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1134454006683 putative alpha-glucosidase; Provisional; Region: PRK10658 1134454006684 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1134454006685 Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599 1134454006686 putative active site [active] 1134454006687 putative catalytic site [active] 1134454006688 beta-D-glucuronidase; Provisional; Region: PRK10150 1134454006689 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1134454006690 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1134454006691 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1134454006692 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 1134454006693 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1134454006694 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1134454006695 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1134454006696 homodimer interface [polypeptide binding]; other site 1134454006697 catalytic residue [active] 1134454006698 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 1134454006699 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1134454006700 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1134454006701 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 1134454006702 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 1134454006703 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1134454006704 ParB-like nuclease domain; Region: ParB; smart00470 1134454006705 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1134454006706 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1134454006707 P-loop; other site 1134454006708 Magnesium ion binding site [ion binding]; other site 1134454006709 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1134454006710 Magnesium ion binding site [ion binding]; other site 1134454006711 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 1134454006712 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 1134454006713 Alanine racemase, N-terminal domain; Region: Ala_racemase_N; pfam01168 1134454006714 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1134454006715 catalytic residue [active] 1134454006716 FemAB family; Region: FemAB; pfam02388 1134454006717 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1134454006718 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 1134454006719 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1134454006720 G-X-X-G motif; other site 1134454006721 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1134454006722 RxxxH motif; other site 1134454006723 putative inner membrane protein translocase component YidC; Provisional; Region: PRK01315 1134454006724 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1134454006725 Haemolytic domain; Region: Haemolytic; pfam01809 1134454006726 Ribonuclease P; Region: Ribonuclease_P; cl00457 1134454006727 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 1134454006728 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1134454006729 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1134454006730 P-loop; other site 1134454006731 Magnesium ion binding site [ion binding]; other site 1134454006732 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1134454006733 Magnesium ion binding site [ion binding]; other site 1134454006734 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1134454006735 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 1134454006736 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1134454006737 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1134454006738 Coenzyme A binding pocket [chemical binding]; other site 1134454006739 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1134454006740 NlpC/P60 family; Region: NLPC_P60; pfam00877 1134454006741 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1134454006742 AAA-like domain; Region: AAA_10; pfam12846 1134454006743 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 1134454006744 RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643 1134454006745 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1134454006746 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1134454006747 P-loop; other site 1134454006748 Magnesium ion binding site [ion binding]; other site 1134454006749 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1134454006750 Magnesium ion binding site [ion binding]; other site 1134454006751 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 1134454006752 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 1134454006753 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 1134454006754 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1134454006755 Walker A motif; other site 1134454006756 ATP binding site [chemical binding]; other site 1134454006757 Walker B motif; other site 1134454006758 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 1134454006759 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1134454006760 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1134454006761 Bacterial transcriptional activator domain; Region: BTAD; smart01043 1134454006762 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1134454006763 HSP70 interaction site [polypeptide binding]; other site 1134454006764 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 1134454006765 nudix motif; other site 1134454006766 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1134454006767 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1134454006768 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1134454006769 P-loop; other site 1134454006770 Magnesium ion binding site [ion binding]; other site 1134454006771 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1134454006772 Abi-like protein; Region: Abi_2; pfam07751 1134454006773 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1134454006774 Resolvase, N terminal domain; Region: Resolvase; pfam00239 1134454006775 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1134454006776 DNA-binding interface [nucleotide binding]; DNA binding site