-- dump date 20140620_000932 -- class Genbank::misc_feature -- table misc_feature_note -- id note 553199000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 553199000002 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 553199000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 553199000004 Walker A motif; other site 553199000005 ATP binding site [chemical binding]; other site 553199000006 Walker B motif; other site 553199000007 arginine finger; other site 553199000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 553199000009 DnaA box-binding interface [nucleotide binding]; other site 553199000010 DNA polymerase III subunit beta; Validated; Region: PRK07761 553199000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 553199000012 putative DNA binding surface [nucleotide binding]; other site 553199000013 dimer interface [polypeptide binding]; other site 553199000014 beta-clamp/clamp loader binding surface; other site 553199000015 beta-clamp/translesion DNA polymerase binding surface; other site 553199000016 recombination protein F; Reviewed; Region: recF; PRK00064 553199000017 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 553199000018 Walker A/P-loop; other site 553199000019 ATP binding site [chemical binding]; other site 553199000020 Q-loop/lid; other site 553199000021 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 553199000022 ABC transporter signature motif; other site 553199000023 Walker B; other site 553199000024 D-loop; other site 553199000025 H-loop/switch region; other site 553199000026 Protein of unknown function (DUF721); Region: DUF721; cl02324 553199000027 ABC transporter; Region: ABC_tran; pfam00005 553199000028 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 553199000029 Q-loop/lid; other site 553199000030 ABC transporter signature motif; other site 553199000031 Walker B; other site 553199000032 D-loop; other site 553199000033 H-loop/switch region; other site 553199000034 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 553199000035 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 553199000036 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 553199000037 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 553199000038 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 553199000039 Mg2+ binding site [ion binding]; other site 553199000040 G-X-G motif; other site 553199000041 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 553199000042 anchoring element; other site 553199000043 dimer interface [polypeptide binding]; other site 553199000044 ATP binding site [chemical binding]; other site 553199000045 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 553199000046 active site 553199000047 putative metal-binding site [ion binding]; other site 553199000048 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 553199000049 DNA gyrase subunit A; Validated; Region: PRK05560 553199000050 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 553199000051 CAP-like domain; other site 553199000052 active site 553199000053 primary dimer interface [polypeptide binding]; other site 553199000054 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 553199000055 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 553199000056 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 553199000057 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 553199000058 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 553199000059 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 553199000060 A subgroup of L-lactate dehydrogenases; Region: LDH_3; cd05290 553199000061 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 553199000062 NAD binding site [chemical binding]; other site 553199000063 dimer interface [polypeptide binding]; other site 553199000064 tetramer (dimer of dimers) interface [polypeptide binding]; other site 553199000065 substrate binding site [chemical binding]; other site 553199000066 Transcriptional regulators [Transcription]; Region: PurR; COG1609 553199000067 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 553199000068 DNA binding site [nucleotide binding] 553199000069 domain linker motif; other site 553199000070 Ligand-binding domain of DNA-binding regulatory protein from Corynebacterium glutamicum which has a unique ability to produce significant amounts of L-glutamate directly from cheap sugar and ammonia; Region: PBP1_LacI_like_13; cd06299 553199000071 dimerization interface [polypeptide binding]; other site 553199000072 putative ligand binding site [chemical binding]; other site 553199000073 D-xylose ABC transporter, ATP-binding protein; Region: xylG; TIGR02633 553199000074 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 553199000075 Q-loop/lid; other site 553199000076 ABC transporter signature motif; other site 553199000077 Walker B; other site 553199000078 D-loop; other site 553199000079 H-loop/switch region; other site 553199000080 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 553199000081 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 553199000082 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 553199000083 TM-ABC transporter signature motif; other site 553199000084 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 553199000085 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 553199000086 ligand binding site [chemical binding]; other site 553199000087 dimerization interface [polypeptide binding]; other site 553199000088 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 553199000089 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 553199000090 substrate binding site [chemical binding]; other site 553199000091 dimer interface [polypeptide binding]; other site 553199000092 ATP binding site [chemical binding]; other site 553199000093 D-ribose pyranase; Provisional; Region: PRK11797 553199000094 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 553199000095 active site 553199000096 phosphorylation site [posttranslational modification] 553199000097 potential frameshift: common BLAST hit: gi|50841516|ref|YP_054743.1| PTS system, galactitol-specific IIC component 553199000098 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 553199000099 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 553199000100 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 553199000101 active site 553199000102 P-loop; other site 553199000103 phosphorylation site [posttranslational modification] 553199000104 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 553199000105 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 553199000106 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 553199000107 PRD domain; Region: PRD; pfam00874 553199000108 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 553199000109 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 553199000110 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 553199000111 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 553199000112 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 553199000113 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 553199000114 pyridoxal 5'-phosphate binding site [chemical binding]; other site 553199000115 homodimer interface [polypeptide binding]; other site 553199000116 catalytic residue [active] 553199000117 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 553199000118 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 553199000119 active site 553199000120 nucleophile elbow; other site 553199000121 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 553199000122 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 553199000123 SAF domain; Region: SAF; pfam08666 553199000124 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 553199000125 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 553199000126 Walker A motif; other site 553199000127 ATP binding site [chemical binding]; other site 553199000128 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 553199000129 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 553199000130 Bacterial transcriptional activator domain; Region: BTAD; smart01043 553199000131 H+ Antiporter protein; Region: 2A0121; TIGR00900 553199000132 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 553199000133 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 553199000134 Potassium binding sites [ion binding]; other site 553199000135 Cesium cation binding sites [ion binding]; other site 553199000136 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 553199000137 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 553199000138 FtsX-like permease family; Region: FtsX; pfam02687 553199000139 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 553199000140 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 553199000141 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 553199000142 Walker A/P-loop; other site 553199000143 ATP binding site [chemical binding]; other site 553199000144 Q-loop/lid; other site 553199000145 ABC transporter signature motif; other site 553199000146 Walker B; other site 553199000147 D-loop; other site 553199000148 H-loop/switch region; other site 553199000149 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 553199000150 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 553199000151 active site 553199000152 phosphorylation site [posttranslational modification] 553199000153 intermolecular recognition site; other site 553199000154 dimerization interface [polypeptide binding]; other site 553199000155 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 553199000156 DNA binding residues [nucleotide binding] 553199000157 dimerization interface [polypeptide binding]; other site 553199000158 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 553199000159 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 553199000160 dimer interface [polypeptide binding]; other site 553199000161 conserved gate region; other site 553199000162 putative PBP binding loops; other site 553199000163 ABC-ATPase subunit interface; other site 553199000164 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 553199000165 dimer interface [polypeptide binding]; other site 553199000166 conserved gate region; other site 553199000167 putative PBP binding loops; other site 553199000168 ABC-ATPase subunit interface; other site 553199000169 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 553199000170 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 553199000171 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 553199000172 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 553199000173 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 553199000174 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 553199000175 NAD binding site [chemical binding]; other site 553199000176 sugar binding site [chemical binding]; other site 553199000177 divalent metal binding site [ion binding]; other site 553199000178 tetramer (dimer of dimers) interface [polypeptide binding]; other site 553199000179 dimer interface [polypeptide binding]; other site 553199000180 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 553199000181 active site 553199000182 catalytic site [active] 553199000183 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 553199000184 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 553199000185 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 553199000186 Sulfatase; Region: Sulfatase; cl17466 553199000187 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 553199000188 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 553199000189 motif II; other site 553199000190 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 553199000191 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 553199000192 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 553199000193 active site 553199000194 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 553199000195 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 553199000196 substrate binding site [chemical binding]; other site 553199000197 ATP binding site [chemical binding]; other site 553199000198 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 553199000199 Histidine kinase; Region: HisKA_3; pfam07730 553199000200 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 553199000201 ATP binding site [chemical binding]; other site 553199000202 Mg2+ binding site [ion binding]; other site 553199000203 G-X-G motif; other site 553199000204 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 553199000205 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 553199000206 NAD(P) binding site [chemical binding]; other site 553199000207 active site 553199000208 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 553199000209 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 553199000210 MMPL family; Region: MMPL; pfam03176 553199000211 MMPL family; Region: MMPL; pfam03176 553199000212 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 553199000213 Predicted membrane protein [Function unknown]; Region: COG1511 553199000214 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 553199000215 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 553199000216 Walker A/P-loop; other site 553199000217 ATP binding site [chemical binding]; other site 553199000218 Q-loop/lid; other site 553199000219 ABC transporter signature motif; other site 553199000220 Walker B; other site 553199000221 D-loop; other site 553199000222 H-loop/switch region; other site 553199000223 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 553199000224 S-adenosylmethionine binding site [chemical binding]; other site 553199000225 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 553199000226 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 553199000227 putative ligand binding residues [chemical binding]; other site 553199000228 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 553199000229 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 553199000230 ABC-ATPase subunit interface; other site 553199000231 dimer interface [polypeptide binding]; other site 553199000232 putative PBP binding regions; other site 553199000233 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 553199000234 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 553199000235 Walker A/P-loop; other site 553199000236 ATP binding site [chemical binding]; other site 553199000237 Q-loop/lid; other site 553199000238 ABC transporter signature motif; other site 553199000239 Walker B; other site 553199000240 D-loop; other site 553199000241 H-loop/switch region; other site 553199000242 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 553199000243 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 553199000244 tetramerization interface [polypeptide binding]; other site 553199000245 NAD(P) binding site [chemical binding]; other site 553199000246 catalytic residues [active] 553199000247 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 553199000248 Putative ClC chloride channel. Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033 553199000249 putative ion selectivity filter; other site 553199000250 putative pore gating glutamate residue; other site 553199000251 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 553199000252 homodimer interface [polypeptide binding]; other site 553199000253 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 553199000254 active site pocket [active] 553199000255 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 553199000256 DNA binding residues [nucleotide binding] 553199000257 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase; Region: TIGR02336 553199000258 Lacto-N-biose phosphorylase; Region: Lact_bio_phlase; pfam09508 553199000259 MarR family; Region: MarR_2; pfam12802 553199000260 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 553199000261 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 553199000262 carbohydrate ABC transporter substrate-binding protein, CPR_0540 family; Region: bind_CPR_0540; TIGR03850 553199000263 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 553199000264 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 553199000265 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 553199000266 dimer interface [polypeptide binding]; other site 553199000267 conserved gate region; other site 553199000268 putative PBP binding loops; other site 553199000269 ABC-ATPase subunit interface; other site 553199000270 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 553199000271 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 553199000272 dimer interface [polypeptide binding]; other site 553199000273 conserved gate region; other site 553199000274 putative PBP binding loops; other site 553199000275 ABC-ATPase subunit interface; other site 553199000276 Transcriptional regulators [Transcription]; Region: PurR; COG1609 553199000277 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 553199000278 DNA binding site [nucleotide binding] 553199000279 domain linker motif; other site 553199000280 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 553199000281 ligand binding site [chemical binding]; other site 553199000282 dimerization interface (open form) [polypeptide binding]; other site 553199000283 dimerization interface (closed form) [polypeptide binding]; other site 553199000284 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 553199000285 6-phosphofructokinase; Provisional; Region: PRK03202 553199000286 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 553199000287 active site 553199000288 ADP/pyrophosphate binding site [chemical binding]; other site 553199000289 dimerization interface [polypeptide binding]; other site 553199000290 allosteric effector site; other site 553199000291 fructose-1,6-bisphosphate binding site; other site 553199000292 Predicted transcriptional regulator [Transcription]; Region: COG2345 553199000293 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 553199000294 putative DNA binding site [nucleotide binding]; other site 553199000295 putative Zn2+ binding site [ion binding]; other site 553199000296 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 553199000297 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 553199000298 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 553199000299 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 553199000300 Aspartase; Region: Aspartase; cd01357 553199000301 active sites [active] 553199000302 tetramer interface [polypeptide binding]; other site 553199000303 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 553199000304 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 553199000305 Predicted acetyltransferase [General function prediction only]; Region: COG2388 553199000306 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 553199000307 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 553199000308 heme binding pocket [chemical binding]; other site 553199000309 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 553199000310 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 553199000311 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 553199000312 Walker A/P-loop; other site 553199000313 ATP binding site [chemical binding]; other site 553199000314 Q-loop/lid; other site 553199000315 ABC transporter signature motif; other site 553199000316 Walker B; other site 553199000317 D-loop; other site 553199000318 H-loop/switch region; other site 553199000319 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 553199000320 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 553199000321 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 553199000322 Q-loop/lid; other site 553199000323 ABC transporter signature motif; other site 553199000324 Walker B; other site 553199000325 D-loop; other site 553199000326 H-loop/switch region; other site 553199000327 Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081 553199000328 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 553199000329 Walker A motif; other site 553199000330 ATP binding site [chemical binding]; other site 553199000331 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 553199000332 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 553199000333 Walker A motif; other site 553199000334 ATP binding site [chemical binding]; other site 553199000335 Walker B motif; other site 553199000336 arginine finger; other site 553199000337 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 553199000338 metal ion-dependent adhesion site (MIDAS); other site 553199000339 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 553199000340 CobN/Magnesium Chelatase; Region: CobN-Mg_chel; pfam02514 553199000341 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 553199000342 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 553199000343 Radical SAM superfamily; Region: Radical_SAM; pfam04055 553199000344 FeS/SAM binding site; other site 553199000345 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 553199000346 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 553199000347 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 553199000348 Walker A/P-loop; other site 553199000349 ATP binding site [chemical binding]; other site 553199000350 Q-loop/lid; other site 553199000351 ABC transporter signature motif; other site 553199000352 Walker B; other site 553199000353 D-loop; other site 553199000354 H-loop/switch region; other site 553199000355 FecCD transport family; Region: FecCD; pfam01032 553199000356 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 553199000357 ABC-ATPase subunit interface; other site 553199000358 dimer interface [polypeptide binding]; other site 553199000359 putative PBP binding regions; other site 553199000360 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 553199000361 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 553199000362 intersubunit interface [polypeptide binding]; other site 553199000363 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 553199000364 Periplasmic binding protein TroA_d. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_d; cd01141 553199000365 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 553199000366 putative ligand binding site [chemical binding]; other site 553199000367 myosin-cross-reactive antigen; Provisional; Region: PRK13977 553199000368 multifunctional hydroxymethylpyrimidine phosphokinase/4-amino-5-aminomethyl-2-methylpyrimidine hydrolase; Provisional; Region: PRK14713 553199000369 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 553199000370 dimer interface [polypeptide binding]; other site 553199000371 substrate binding site [chemical binding]; other site 553199000372 ATP binding site [chemical binding]; other site 553199000373 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 553199000374 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 553199000375 thiamine phosphate binding site [chemical binding]; other site 553199000376 active site 553199000377 pyrophosphate binding site [ion binding]; other site 553199000378 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 553199000379 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 553199000380 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 553199000381 Soluble P-type ATPase [General function prediction only]; Region: COG4087 553199000382 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 553199000383 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 553199000384 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 553199000385 Ligand Binding Site [chemical binding]; other site 553199000386 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 553199000387 dimer interface [polypeptide binding]; other site 553199000388 phosphorylation site [posttranslational modification] 553199000389 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 553199000390 ATP binding site [chemical binding]; other site 553199000391 Mg2+ binding site [ion binding]; other site 553199000392 G-X-G motif; other site 553199000393 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 553199000394 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 553199000395 active site 553199000396 phosphorylation site [posttranslational modification] 553199000397 intermolecular recognition site; other site 553199000398 dimerization interface [polypeptide binding]; other site 553199000399 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 553199000400 DNA binding site [nucleotide binding] 553199000401 EXLDI protein; Region: EXLDI; TIGR04342 553199000402 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 553199000403 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 553199000404 Walker A/P-loop; other site 553199000405 ATP binding site [chemical binding]; other site 553199000406 Q-loop/lid; other site 553199000407 ABC transporter signature motif; other site 553199000408 Walker B; other site 553199000409 D-loop; other site 553199000410 H-loop/switch region; other site 553199000411 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 553199000412 potential frameshift: common BLAST hit: gi|50914470|ref|YP_060442.1| site-specific recombinase 553199000413 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 553199000414 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 553199000415 catalytic residues [active] 553199000416 catalytic nucleophile [active] 553199000417 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 553199000418 Recombinase; Region: Recombinase; pfam07508 553199000419 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 553199000420 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 553199000421 catalytic residues [active] 553199000422 catalytic nucleophile [active] 553199000423 Recombinase; Region: Recombinase; pfam07508 553199000424 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 553199000425 Homeodomain-like domain; Region: HTH_23; pfam13384 553199000426 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 553199000427 amidase catalytic site [active] 553199000428 Zn binding residues [ion binding]; other site 553199000429 substrate binding site [chemical binding]; other site 553199000430 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 553199000431 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 553199000432 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 553199000433 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 553199000434 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 553199000435 Transglycosylase; Region: Transgly; pfam00912 553199000436 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 553199000437 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 553199000438 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 553199000439 Mannosyltransferase (PIG-V)); Region: Mannosyl_trans2; pfam04188 553199000440 This family is most closely related to the GT1 family of glycosyltransferases. AmsK is involved in the biosynthesis of amylovoran, which functions as a virulence factor. It functions as a glycosyl transferase which transfers galactose from UDP-galactose...; Region: GT1_AmsK_like; cd04946 553199000441 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 553199000442 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 553199000443 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 553199000444 O-Antigen ligase; Region: Wzy_C; pfam04932 553199000445 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 553199000446 putative trimer interface [polypeptide binding]; other site 553199000447 putative CoA binding site [chemical binding]; other site 553199000448 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 553199000449 putative trimer interface [polypeptide binding]; other site 553199000450 putative active site [active] 553199000451 putative substrate binding site [chemical binding]; other site 553199000452 putative CoA binding site [chemical binding]; other site 553199000453 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 553199000454 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 553199000455 inhibitor-cofactor binding pocket; inhibition site 553199000456 pyridoxal 5'-phosphate binding site [chemical binding]; other site 553199000457 catalytic residue [active] 553199000458 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 553199000459 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 553199000460 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 553199000461 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 553199000462 O-Antigen ligase; Region: Wzy_C; pfam04932 553199000463 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 553199000464 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 553199000465 POT family; Region: PTR2; cl17359 553199000466 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 553199000467 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 553199000468 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 553199000469 classical (c) SDRs; Region: SDR_c; cd05233 553199000470 NAD(P) binding site [chemical binding]; other site 553199000471 active site 553199000472 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 553199000473 dimerization domain swap beta strand [polypeptide binding]; other site 553199000474 regulatory protein interface [polypeptide binding]; other site 553199000475 active site 553199000476 regulatory phosphorylation site [posttranslational modification]; other site 553199000477 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 553199000478 active site 553199000479 phosphorylation site [posttranslational modification] 553199000480 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 553199000481 active site 553199000482 P-loop; other site 553199000483 phosphorylation site [posttranslational modification] 553199000484 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 553199000485 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 553199000486 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 553199000487 putative substrate binding site [chemical binding]; other site 553199000488 putative ATP binding site [chemical binding]; other site 553199000489 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 553199000490 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 553199000491 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 553199000492 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 553199000493 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 553199000494 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 553199000495 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 553199000496 O-Antigen ligase; Region: Wzy_C; pfam04932 553199000497 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 553199000498 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 553199000499 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 553199000500 active site 553199000501 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 553199000502 homodimer interface [polypeptide binding]; other site 553199000503 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 553199000504 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 553199000505 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 553199000506 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 553199000507 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 553199000508 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 553199000509 nudix motif; other site 553199000510 HrpA-like helicases [DNA replication, recombination, and repair]; Region: HrpA; COG1643 553199000511 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 553199000512 ATP binding site [chemical binding]; other site 553199000513 putative Mg++ binding site [ion binding]; other site 553199000514 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 553199000515 nucleotide binding region [chemical binding]; other site 553199000516 ATP-binding site [chemical binding]; other site 553199000517 Helicase associated domain (HA2); Region: HA2; pfam04408 553199000518 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 553199000519 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 553199000520 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 553199000521 P-loop; other site 553199000522 Magnesium ion binding site [ion binding]; other site 553199000523 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 553199000524 Magnesium ion binding site [ion binding]; other site 553199000525 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 553199000526 DNA binding residues [nucleotide binding] 553199000527 AAA domain; Region: AAA_31; pfam13614 553199000528 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 553199000529 CAAX protease self-immunity; Region: Abi; pfam02517 553199000530 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 553199000531 YcaO-like family; Region: YcaO; pfam02624 553199000532 thiazole/oxazole-forming peptide maturase, SagC family component; Region: cyclo_dehy_ocin; TIGR03603 553199000533 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 553199000534 putative FMN binding site [chemical binding]; other site 553199000535 NADPH bind site [chemical binding]; other site 553199000536 EXLDI protein; Region: EXLDI; TIGR04342 553199000537 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 553199000538 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 553199000539 Walker A/P-loop; other site 553199000540 ATP binding site [chemical binding]; other site 553199000541 Q-loop/lid; other site 553199000542 ABC transporter signature motif; other site 553199000543 Walker B; other site 553199000544 D-loop; other site 553199000545 H-loop/switch region; other site 553199000546 ABC-2 type transporter; Region: ABC2_membrane; cl17235 553199000547 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 553199000548 Abi-like protein; Region: Abi_2; pfam07751 553199000549 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 553199000550 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 553199000551 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 553199000552 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 553199000553 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 553199000554 Walker A/P-loop; other site 553199000555 ATP binding site [chemical binding]; other site 553199000556 Q-loop/lid; other site 553199000557 ABC transporter signature motif; other site 553199000558 Walker B; other site 553199000559 D-loop; other site 553199000560 H-loop/switch region; other site 553199000561 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 553199000562 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 553199000563 Walker A/P-loop; other site 553199000564 ATP binding site [chemical binding]; other site 553199000565 Q-loop/lid; other site 553199000566 ABC transporter signature motif; other site 553199000567 Walker B; other site 553199000568 D-loop; other site 553199000569 H-loop/switch region; other site 553199000570 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 553199000571 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 553199000572 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 553199000573 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565 553199000574 Dihydroorotate dehydrogenase (DHOD) like proteins. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_like; cd04739 553199000575 putative active site [active] 553199000576 putative FMN binding site [chemical binding]; other site 553199000577 putative substrate binding site [chemical binding]; other site 553199000578 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 553199000579 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 553199000580 dimer interface [polypeptide binding]; other site 553199000581 PYR/PP interface [polypeptide binding]; other site 553199000582 TPP binding site [chemical binding]; other site 553199000583 substrate binding site [chemical binding]; other site 553199000584 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 553199000585 Domain of unknown function; Region: EKR; smart00890 553199000586 4Fe-4S binding domain; Region: Fer4_6; pfam12837 553199000587 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 553199000588 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 553199000589 TPP-binding site [chemical binding]; other site 553199000590 dimer interface [polypeptide binding]; other site 553199000591 putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771 553199000592 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 553199000593 4Fe-4S binding domain; Region: Fer4; pfam00037 553199000594 Domain of unknown function DUF77; Region: DUF77; pfam01910 553199000595 Transcriptional regulators [Transcription]; Region: FadR; COG2186 553199000596 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 553199000597 DNA-binding site [nucleotide binding]; DNA binding site 553199000598 FCD domain; Region: FCD; pfam07729 553199000599 L-lactate permease; Region: Lactate_perm; cl00701 553199000600 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 553199000601 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 553199000602 Cysteine-rich domain; Region: CCG; pfam02754 553199000603 Cysteine-rich domain; Region: CCG; pfam02754 553199000604 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 553199000605 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 553199000606 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 553199000607 Uncharacterized conserved protein [Function unknown]; Region: COG1556 553199000608 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 553199000609 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 553199000610 Walker A/P-loop; other site 553199000611 ATP binding site [chemical binding]; other site 553199000612 Q-loop/lid; other site 553199000613 ABC transporter signature motif; other site 553199000614 Walker B; other site 553199000615 D-loop; other site 553199000616 H-loop/switch region; other site 553199000617 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 553199000618 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 553199000619 Walker A/P-loop; other site 553199000620 ATP binding site [chemical binding]; other site 553199000621 Q-loop/lid; other site 553199000622 ABC transporter signature motif; other site 553199000623 Walker B; other site 553199000624 D-loop; other site 553199000625 H-loop/switch region; other site 553199000626 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 553199000627 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 553199000628 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 553199000629 Walker A/P-loop; other site 553199000630 ATP binding site [chemical binding]; other site 553199000631 Q-loop/lid; other site 553199000632 ABC transporter signature motif; other site 553199000633 Walker B; other site 553199000634 D-loop; other site 553199000635 H-loop/switch region; other site 553199000636 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 553199000637 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 553199000638 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 553199000639 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 553199000640 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 553199000641 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 553199000642 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 553199000643 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 553199000644 Walker A/P-loop; other site 553199000645 ATP binding site [chemical binding]; other site 553199000646 Q-loop/lid; other site 553199000647 ABC transporter signature motif; other site 553199000648 Walker B; other site 553199000649 D-loop; other site 553199000650 H-loop/switch region; other site 553199000651 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 553199000652 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 553199000653 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 553199000654 Walker A/P-loop; other site 553199000655 ATP binding site [chemical binding]; other site 553199000656 Q-loop/lid; other site 553199000657 ABC transporter signature motif; other site 553199000658 Walker B; other site 553199000659 D-loop; other site 553199000660 H-loop/switch region; other site 553199000661 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 553199000662 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 553199000663 non-specific DNA binding site [nucleotide binding]; other site 553199000664 salt bridge; other site 553199000665 sequence-specific DNA binding site [nucleotide binding]; other site 553199000666 Domain of unknown function (DUF955); Region: DUF955; pfam06114 553199000667 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 553199000668 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 553199000669 dimer interface [polypeptide binding]; other site 553199000670 putative anticodon binding site; other site 553199000671 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 553199000672 motif 1; other site 553199000673 dimer interface [polypeptide binding]; other site 553199000674 active site 553199000675 motif 2; other site 553199000676 motif 3; other site 553199000677 Uncharacterized protein family (UPF0233); Region: UPF0233; pfam06781 553199000678 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 553199000679 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 553199000680 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 553199000681 active site 553199000682 ATP binding site [chemical binding]; other site 553199000683 substrate binding site [chemical binding]; other site 553199000684 activation loop (A-loop); other site 553199000685 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 553199000686 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 553199000687 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 553199000688 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 553199000689 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 553199000690 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 553199000691 active site 553199000692 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 553199000693 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 553199000694 phosphopeptide binding site; other site 553199000695 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 553199000696 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 553199000697 phosphopeptide binding site; other site 553199000698 Phosphotransferase enzyme family; Region: APH; pfam01636 553199000699 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 553199000700 active site 553199000701 ATP binding site [chemical binding]; other site 553199000702 potential frameshift: common BLAST hit: gi|50841684|ref|YP_054911.1| putative RHS-family protein 553199000703 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 553199000704 RHS Repeat; Region: RHS_repeat; cl11982 553199000705 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 553199000706 RHS Repeat; Region: RHS_repeat; cl11982 553199000707 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 553199000708 RHS Repeat; Region: RHS_repeat; pfam05593 553199000709 RHS Repeat; Region: RHS_repeat; cl11982 553199000710 RHS Repeat; Region: RHS_repeat; pfam05593 553199000711 RHS Repeat; Region: RHS_repeat; pfam05593 553199000712 RHS Repeat; Region: RHS_repeat; pfam05593 553199000713 RHS Repeat; Region: RHS_repeat; pfam05593 553199000714 RHS Repeat; Region: RHS_repeat; pfam05593 553199000715 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 553199000716 RHS Repeat; Region: RHS_repeat; pfam05593 553199000717 RHS Repeat; Region: RHS_repeat; pfam05593 553199000718 RHS Repeat; Region: RHS_repeat; pfam05593 553199000719 RHS Repeat; Region: RHS_repeat; pfam05593 553199000720 RHS Repeat; Region: RHS_repeat; cl11982 553199000721 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 553199000722 RHS Repeat; Region: RHS_repeat; cl11982 553199000723 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 553199000724 RHS Repeat; Region: RHS_repeat; pfam05593 553199000725 RHS Repeat; Region: RHS_repeat; pfam05593 553199000726 RHS Repeat; Region: RHS_repeat; pfam05593 553199000727 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 553199000728 RHS Repeat; Region: RHS_repeat; pfam05593 553199000729 RHS Repeat; Region: RHS_repeat; pfam05593 553199000730 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 553199000731 RNA binding surface [nucleotide binding]; other site 553199000732 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 553199000733 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 553199000734 Walker A motif; other site 553199000735 ATP binding site [chemical binding]; other site 553199000736 Walker B motif; other site 553199000737 arginine finger; other site 553199000738 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 553199000739 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG0718 553199000740 recombination protein RecR; Reviewed; Region: recR; PRK00076 553199000741 RecR protein; Region: RecR; pfam02132 553199000742 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 553199000743 putative active site [active] 553199000744 putative metal-binding site [ion binding]; other site 553199000745 tetramer interface [polypeptide binding]; other site 553199000746 Predicted transcriptional regulators [Transcription]; Region: COG1695 553199000747 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 553199000748 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 553199000749 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 553199000750 Walker A/P-loop; other site 553199000751 ATP binding site [chemical binding]; other site 553199000752 Q-loop/lid; other site 553199000753 ABC transporter signature motif; other site 553199000754 Walker B; other site 553199000755 D-loop; other site 553199000756 H-loop/switch region; other site 553199000757 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 553199000758 Uncharacterized conserved protein [Function unknown]; Region: COG2966 553199000759 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 553199000760 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 553199000761 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 553199000762 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 553199000763 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 553199000764 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 553199000765 active site 553199000766 motif I; other site 553199000767 motif II; other site 553199000768 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 553199000769 Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060 553199000770 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 553199000771 active site 553199000772 HIGH motif; other site 553199000773 nucleotide binding site [chemical binding]; other site 553199000774 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 553199000775 active site 553199000776 KMSKS motif; other site 553199000777 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 553199000778 tRNA binding surface [nucleotide binding]; other site 553199000779 anticodon binding site; other site 553199000780 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 553199000781 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 553199000782 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 553199000783 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 553199000784 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 553199000785 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 553199000786 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 553199000787 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 553199000788 homotrimer interaction site [polypeptide binding]; other site 553199000789 putative active site [active] 553199000790 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 553199000791 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 553199000792 ligand binding site [chemical binding]; other site 553199000793 flexible hinge region; other site 553199000794 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 553199000795 putative switch regulator; other site 553199000796 non-specific DNA interactions [nucleotide binding]; other site 553199000797 DNA binding site [nucleotide binding] 553199000798 sequence specific DNA binding site [nucleotide binding]; other site 553199000799 putative cAMP binding site [chemical binding]; other site 553199000800 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 553199000801 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 553199000802 minor groove reading motif; other site 553199000803 helix-hairpin-helix signature motif; other site 553199000804 substrate binding pocket [chemical binding]; other site 553199000805 active site 553199000806 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 553199000807 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 553199000808 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 553199000809 putative active site [active] 553199000810 putative CoA binding site [chemical binding]; other site 553199000811 nudix motif; other site 553199000812 metal binding site [ion binding]; metal-binding site 553199000813 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 553199000814 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 553199000815 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 553199000816 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 553199000817 helicase/secretion neighborhood ATPase; Region: heli_sec_ATPase; TIGR03819 553199000818 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 553199000819 Walker A motif; other site 553199000820 ATP binding site [chemical binding]; other site 553199000821 Walker B motif; other site 553199000822 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 553199000823 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 553199000824 helicase/secretion neighborhood TadE-like protein; Region: tadE_like_DECH; TIGR03816 553199000825 Predicted ATPase [General function prediction only]; Region: COG4637 553199000826 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 553199000827 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 553199000828 ATP binding site [chemical binding]; other site 553199000829 putative Mg++ binding site [ion binding]; other site 553199000830 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 553199000831 nucleotide binding region [chemical binding]; other site 553199000832 ATP-binding site [chemical binding]; other site 553199000833 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 553199000834 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 553199000835 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 553199000836 S-adenosylmethionine binding site [chemical binding]; other site 553199000837 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 553199000838 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 553199000839 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 553199000840 active site 553199000841 interdomain interaction site; other site 553199000842 putative metal-binding site [ion binding]; other site 553199000843 nucleotide binding site [chemical binding]; other site 553199000844 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 553199000845 domain I; other site 553199000846 DNA binding groove [nucleotide binding] 553199000847 phosphate binding site [ion binding]; other site 553199000848 domain II; other site 553199000849 domain III; other site 553199000850 nucleotide binding site [chemical binding]; other site 553199000851 catalytic site [active] 553199000852 domain IV; other site 553199000853 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 553199000854 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 553199000855 thymidylate kinase; Validated; Region: tmk; PRK00698 553199000856 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 553199000857 TMP-binding site; other site 553199000858 ATP-binding site [chemical binding]; other site 553199000859 DNA polymerase III subunit delta'; Validated; Region: PRK07940 553199000860 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 553199000861 Walker A motif; other site 553199000862 ATP binding site [chemical binding]; other site 553199000863 Walker B motif; other site 553199000864 arginine finger; other site 553199000865 Predicted membrane protein [Function unknown]; Region: COG2259 553199000866 PSP1 C-terminal conserved region; Region: PSP1; cl00770 553199000867 TAP-like protein; Region: Abhydrolase_4; pfam08386 553199000868 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 553199000869 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 553199000870 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 553199000871 catalytic core [active] 553199000872 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 553199000873 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 553199000874 Methyltransferase domain; Region: Methyltransf_26; pfam13659 553199000875 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 553199000876 dimer interface [polypeptide binding]; other site 553199000877 substrate binding site [chemical binding]; other site 553199000878 metal binding sites [ion binding]; metal-binding site 553199000879 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 553199000880 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 553199000881 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 553199000882 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 553199000883 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 553199000884 Ligand Binding Site [chemical binding]; other site 553199000885 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 553199000886 active site 553199000887 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 553199000888 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 553199000889 Walker A motif; other site 553199000890 ATP binding site [chemical binding]; other site 553199000891 Walker B motif; other site 553199000892 arginine finger; other site 553199000893 Peptidase family M41; Region: Peptidase_M41; pfam01434 553199000894 Protein of unknown function (DUF3729); Region: DUF3729; pfam12526 553199000895 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 553199000896 homodecamer interface [polypeptide binding]; other site 553199000897 GTP cyclohydrolase I; Provisional; Region: PLN03044 553199000898 active site 553199000899 putative catalytic site residues [active] 553199000900 zinc binding site [ion binding]; other site 553199000901 GTP-CH-I/GFRP interaction surface; other site 553199000902 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 553199000903 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 553199000904 ligand binding site [chemical binding]; other site 553199000905 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 553199000906 dihydropteroate synthase; Region: DHPS; TIGR01496 553199000907 substrate binding pocket [chemical binding]; other site 553199000908 dimer interface [polypeptide binding]; other site 553199000909 inhibitor binding site; inhibition site 553199000910 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 553199000911 homooctamer interface [polypeptide binding]; other site 553199000912 active site 553199000913 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 553199000914 catalytic center binding site [active] 553199000915 ATP binding site [chemical binding]; other site 553199000916 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 553199000917 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 553199000918 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 553199000919 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 553199000920 Lsr2; Region: Lsr2; pfam11774 553199000921 Clp protease ATP binding subunit; Region: clpC; CHL00095 553199000922 Clp amino terminal domain; Region: Clp_N; pfam02861 553199000923 Clp amino terminal domain; Region: Clp_N; pfam02861 553199000924 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 553199000925 Walker A motif; other site 553199000926 ATP binding site [chemical binding]; other site 553199000927 Walker B motif; other site 553199000928 arginine finger; other site 553199000929 UvrB/uvrC motif; Region: UVR; pfam02151 553199000930 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 553199000931 Walker A motif; other site 553199000932 ATP binding site [chemical binding]; other site 553199000933 Walker B motif; other site 553199000934 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 553199000935 Protein of unknown function (DUF2891); Region: DUF2891; pfam11199 553199000936 Predicted membrane protein [Function unknown]; Region: COG3817 553199000937 Protein of unknown function (DUF979); Region: DUF979; pfam06166 553199000938 Protein of unknown function (DUF969); Region: DUF969; pfam06149 553199000939 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 553199000940 putative active site [active] 553199000941 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 553199000942 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 553199000943 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 553199000944 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 553199000945 putative substrate translocation pore; other site 553199000946 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 553199000947 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 553199000948 TIGR01777 family protein; Region: yfcH 553199000949 putative NAD(P) binding site [chemical binding]; other site 553199000950 putative active site [active] 553199000951 Rhomboid family; Region: Rhomboid; pfam01694 553199000952 hypothetical protein; Provisional; Region: PRK06547 553199000953 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 553199000954 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 553199000955 active site 553199000956 phosphorylation site [posttranslational modification] 553199000957 intermolecular recognition site; other site 553199000958 dimerization interface [polypeptide binding]; other site 553199000959 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 553199000960 DNA binding residues [nucleotide binding] 553199000961 dimerization interface [polypeptide binding]; other site 553199000962 Histidine kinase; Region: HisKA_3; pfam07730 553199000963 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 553199000964 ATP binding site [chemical binding]; other site 553199000965 Mg2+ binding site [ion binding]; other site 553199000966 G-X-G motif; other site 553199000967 CAT RNA binding domain; Region: CAT_RBD; smart01061 553199000968 transcriptional antiterminator BglG; Provisional; Region: PRK09772 553199000969 PRD domain; Region: PRD; pfam00874 553199000970 PRD domain; Region: PRD; pfam00874 553199000971 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 553199000972 HPr interaction site; other site 553199000973 glycerol kinase (GK) interaction site [polypeptide binding]; other site 553199000974 active site 553199000975 phosphorylation site [posttranslational modification] 553199000976 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 553199000977 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 553199000978 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 553199000979 active site turn [active] 553199000980 phosphorylation site [posttranslational modification] 553199000981 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 553199000982 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 553199000983 endonuclease III; Region: ENDO3c; smart00478 553199000984 minor groove reading motif; other site 553199000985 helix-hairpin-helix signature motif; other site 553199000986 active site 553199000987 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 553199000988 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 553199000989 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 553199000990 inhibitor-cofactor binding pocket; inhibition site 553199000991 pyridoxal 5'-phosphate binding site [chemical binding]; other site 553199000992 catalytic residue [active] 553199000993 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 553199000994 dimer interface [polypeptide binding]; other site 553199000995 active site 553199000996 Schiff base residues; other site 553199000997 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 553199000998 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 553199000999 active site 553199001000 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 553199001001 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 553199001002 domain interfaces; other site 553199001003 active site 553199001004 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 553199001005 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 553199001006 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 553199001007 substrate binding site [chemical binding]; other site 553199001008 active site 553199001009 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 553199001010 Glutamyl-tRNAGlu reductase, N-terminal domain; Region: GlutR_N; pfam05201 553199001011 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 553199001012 ferrochelatase; Reviewed; Region: hemH; PRK00035 553199001013 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 553199001014 C-terminal domain interface [polypeptide binding]; other site 553199001015 active site 553199001016 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 553199001017 active site 553199001018 N-terminal domain interface [polypeptide binding]; other site 553199001019 Chlorite dismutase; Region: Chlor_dismutase; pfam06778 553199001020 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 553199001021 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 553199001022 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 553199001023 DNA repair protein RadA; Provisional; Region: PRK11823 553199001024 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 553199001025 Walker A motif; other site 553199001026 ATP binding site [chemical binding]; other site 553199001027 Walker B motif; other site 553199001028 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 553199001029 malate dehydrogenase; Provisional; Region: PRK13529 553199001030 Malic enzyme, N-terminal domain; Region: malic; pfam00390 553199001031 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 553199001032 NAD(P) binding site [chemical binding]; other site 553199001033 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 553199001034 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 553199001035 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 553199001036 AP (apurinic/apyrimidinic) site pocket; other site 553199001037 DNA interaction; other site 553199001038 Metal-binding active site; metal-binding site 553199001039 Proline dehydrogenase; Region: Pro_dh; cl03282 553199001040 CAAX protease self-immunity; Region: Abi; pfam02517 553199001041 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 553199001042 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 553199001043 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 553199001044 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 553199001045 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 553199001046 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 553199001047 active site 553199001048 homodimer interface [polypeptide binding]; other site 553199001049 SAM binding site [chemical binding]; other site 553199001050 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 553199001051 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 553199001052 active site 553199001053 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 553199001054 catalytic core [active] 553199001055 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 553199001056 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 553199001057 catalytic residues [active] 553199001058 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 553199001059 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 553199001060 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 553199001061 ResB-like family; Region: ResB; pfam05140 553199001062 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 553199001063 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 553199001064 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 553199001065 DNA binding residues [nucleotide binding] 553199001066 Sporulation and spore germination; Region: Germane; pfam10646 553199001067 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 553199001068 classical (c) SDRs; Region: SDR_c; cd05233 553199001069 NAD(P) binding site [chemical binding]; other site 553199001070 active site 553199001071 mycothione reductase; Reviewed; Region: PRK07846 553199001072 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 553199001073 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 553199001074 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 553199001075 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 553199001076 intersubunit interface [polypeptide binding]; other site 553199001077 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 553199001078 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 553199001079 Walker A/P-loop; other site 553199001080 ATP binding site [chemical binding]; other site 553199001081 Q-loop/lid; other site 553199001082 ABC transporter signature motif; other site 553199001083 Walker B; other site 553199001084 D-loop; other site 553199001085 H-loop/switch region; other site 553199001086 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 553199001087 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 553199001088 ABC-ATPase subunit interface; other site 553199001089 dimer interface [polypeptide binding]; other site 553199001090 putative PBP binding regions; other site 553199001091 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 553199001092 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 553199001093 FAD binding pocket [chemical binding]; other site 553199001094 FAD binding motif [chemical binding]; other site 553199001095 phosphate binding motif [ion binding]; other site 553199001096 NAD binding pocket [chemical binding]; other site 553199001097 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 553199001098 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 553199001099 Walker A/P-loop; other site 553199001100 ATP binding site [chemical binding]; other site 553199001101 Q-loop/lid; other site 553199001102 ABC transporter signature motif; other site 553199001103 Walker B; other site 553199001104 D-loop; other site 553199001105 H-loop/switch region; other site 553199001106 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 553199001107 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 553199001108 dimer interface [polypeptide binding]; other site 553199001109 conserved gate region; other site 553199001110 putative PBP binding loops; other site 553199001111 ABC-ATPase subunit interface; other site 553199001112 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 553199001113 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 553199001114 dimer interface [polypeptide binding]; other site 553199001115 conserved gate region; other site 553199001116 putative PBP binding loops; other site 553199001117 ABC-ATPase subunit interface; other site 553199001118 PBP superfamily domain; Region: PBP_like_2; cl17296 553199001119 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 553199001120 active site 553199001121 Ap6A binding site [chemical binding]; other site 553199001122 nudix motif; other site 553199001123 metal binding site [ion binding]; metal-binding site 553199001124 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 553199001125 catalytic core [active] 553199001126 polyphosphate kinase; Provisional; Region: PRK05443 553199001127 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 553199001128 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 553199001129 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 553199001130 putative domain interface [polypeptide binding]; other site 553199001131 putative active site [active] 553199001132 catalytic site [active] 553199001133 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 553199001134 putative domain interface [polypeptide binding]; other site 553199001135 putative active site [active] 553199001136 catalytic site [active] 553199001137 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 553199001138 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 553199001139 DNA binding site [nucleotide binding] 553199001140 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 553199001141 putative active site [active] 553199001142 dimerization interface [polypeptide binding]; other site 553199001143 putative tRNAtyr binding site [nucleotide binding]; other site 553199001144 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 553199001145 heme-binding site [chemical binding]; other site 553199001146 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 553199001147 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 553199001148 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 553199001149 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 553199001150 Bacterial sugar transferase; Region: Bac_transf; pfam02397 553199001151 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 553199001152 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 553199001153 NAD(P) binding site [chemical binding]; other site 553199001154 active site 553199001155 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 553199001156 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 553199001157 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 553199001158 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 553199001159 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 553199001160 dimerization domain swap beta strand [polypeptide binding]; other site 553199001161 regulatory protein interface [polypeptide binding]; other site 553199001162 active site 553199001163 regulatory phosphorylation site [posttranslational modification]; other site 553199001164 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 553199001165 substrate binding site; other site 553199001166 dimer interface; other site 553199001167 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829 553199001168 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 553199001169 active site 553199001170 P-loop; other site 553199001171 phosphorylation site [posttranslational modification] 553199001172 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 553199001173 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 553199001174 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 553199001175 active site 553199001176 phosphorylation site [posttranslational modification] 553199001177 intermolecular recognition site; other site 553199001178 dimerization interface [polypeptide binding]; other site 553199001179 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 553199001180 DNA binding site [nucleotide binding] 553199001181 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 553199001182 dimer interface [polypeptide binding]; other site 553199001183 phosphorylation site [posttranslational modification] 553199001184 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 553199001185 ATP binding site [chemical binding]; other site 553199001186 Mg2+ binding site [ion binding]; other site 553199001187 G-X-G motif; other site 553199001188 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 553199001189 PhoU domain; Region: PhoU; pfam01895 553199001190 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 553199001191 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 553199001192 NodB motif; other site 553199001193 active site 553199001194 catalytic site [active] 553199001195 Zn binding site [ion binding]; other site 553199001196 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 553199001197 catalytic core [active] 553199001198 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 553199001199 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 553199001200 active site 553199001201 phosphorylation site [posttranslational modification] 553199001202 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 553199001203 active site 553199001204 P-loop; other site 553199001205 phosphorylation site [posttranslational modification] 553199001206 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 553199001207 active site 553199001208 homodimer interface [polypeptide binding]; other site 553199001209 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 553199001210 serine hydroxymethyltransferase; Provisional; Region: PRK13580 553199001211 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 553199001212 dimer interface [polypeptide binding]; other site 553199001213 active site 553199001214 glycine-pyridoxal phosphate binding site [chemical binding]; other site 553199001215 folate binding site [chemical binding]; other site 553199001216 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 553199001217 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 553199001218 substrate binding site [chemical binding]; other site 553199001219 ATP binding site [chemical binding]; other site 553199001220 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 553199001221 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 553199001222 active site 553199001223 intersubunit interface [polypeptide binding]; other site 553199001224 catalytic residue [active] 553199001225 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 553199001226 NAD binding site [chemical binding]; other site 553199001227 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 553199001228 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 553199001229 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 553199001230 substrate binding site [chemical binding]; other site 553199001231 catalytic residues [active] 553199001232 Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; cl01752 553199001233 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 553199001234 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 553199001235 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 553199001236 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 553199001237 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 553199001238 active site 553199001239 HIGH motif; other site 553199001240 nucleotide binding site [chemical binding]; other site 553199001241 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 553199001242 KMSKS motif; other site 553199001243 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 553199001244 tRNA binding surface [nucleotide binding]; other site 553199001245 anticodon binding site; other site 553199001246 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 553199001247 Asp23 family; Region: Asp23; pfam03780 553199001248 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 553199001249 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 553199001250 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 553199001251 DNA binding residues [nucleotide binding] 553199001252 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 553199001253 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 553199001254 Walker A/P-loop; other site 553199001255 ATP binding site [chemical binding]; other site 553199001256 Q-loop/lid; other site 553199001257 ABC transporter signature motif; other site 553199001258 Walker B; other site 553199001259 D-loop; other site 553199001260 H-loop/switch region; other site 553199001261 TOBE domain; Region: TOBE_2; pfam08402 553199001262 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 553199001263 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 553199001264 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 553199001265 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 553199001266 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 553199001267 putative DNA binding site [nucleotide binding]; other site 553199001268 putative Zn2+ binding site [ion binding]; other site 553199001269 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 553199001270 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 553199001271 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 553199001272 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 553199001273 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 553199001274 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 553199001275 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 553199001276 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 553199001277 dimer interface [polypeptide binding]; other site 553199001278 conserved gate region; other site 553199001279 putative PBP binding loops; other site 553199001280 ABC-ATPase subunit interface; other site 553199001281 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 553199001282 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 553199001283 dimer interface [polypeptide binding]; other site 553199001284 conserved gate region; other site 553199001285 ABC-ATPase subunit interface; other site 553199001286 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 553199001287 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 553199001288 NAD(P) binding site [chemical binding]; other site 553199001289 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 553199001290 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 553199001291 substrate-cofactor binding pocket; other site 553199001292 pyridoxal 5'-phosphate binding site [chemical binding]; other site 553199001293 catalytic residue [active] 553199001294 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 553199001295 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 553199001296 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 553199001297 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 553199001298 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 553199001299 Walker A/P-loop; other site 553199001300 ATP binding site [chemical binding]; other site 553199001301 Q-loop/lid; other site 553199001302 ABC transporter signature motif; other site 553199001303 Walker B; other site 553199001304 D-loop; other site 553199001305 H-loop/switch region; other site 553199001306 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 553199001307 Protein of unknown function, DUF488; Region: DUF488; cl01246 553199001308 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 553199001309 putative ADP-ribose binding site [chemical binding]; other site 553199001310 putative active site [active] 553199001311 Prostaglandin dehydrogenases; Region: PGDH; cd05288 553199001312 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 553199001313 NAD(P) binding site [chemical binding]; other site 553199001314 substrate binding site [chemical binding]; other site 553199001315 dimer interface [polypeptide binding]; other site 553199001316 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 553199001317 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 553199001318 Walker A/P-loop; other site 553199001319 ATP binding site [chemical binding]; other site 553199001320 Q-loop/lid; other site 553199001321 ABC transporter signature motif; other site 553199001322 Walker B; other site 553199001323 D-loop; other site 553199001324 H-loop/switch region; other site 553199001325 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 553199001326 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 553199001327 Histidine kinase; Region: HisKA_3; pfam07730 553199001328 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 553199001329 ATP binding site [chemical binding]; other site 553199001330 Mg2+ binding site [ion binding]; other site 553199001331 G-X-G motif; other site 553199001332 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 553199001333 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 553199001334 active site 553199001335 phosphorylation site [posttranslational modification] 553199001336 intermolecular recognition site; other site 553199001337 dimerization interface [polypeptide binding]; other site 553199001338 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 553199001339 DNA binding residues [nucleotide binding] 553199001340 dimerization interface [polypeptide binding]; other site 553199001341 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 553199001342 catalytic core [active] 553199001343 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 553199001344 cobyric acid synthase; Provisional; Region: PRK00784 553199001345 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 553199001346 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 553199001347 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 553199001348 catalytic triad [active] 553199001349 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 553199001350 active site 553199001351 SAM binding site [chemical binding]; other site 553199001352 homodimer interface [polypeptide binding]; other site 553199001353 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 553199001354 active site 553199001355 SAM binding site [chemical binding]; other site 553199001356 homodimer interface [polypeptide binding]; other site 553199001357 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 553199001358 putative homodimer interface [polypeptide binding]; other site 553199001359 active site 553199001360 SAM binding site [chemical binding]; other site 553199001361 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 553199001362 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 553199001363 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 553199001364 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 553199001365 active site 553199001366 SAM binding site [chemical binding]; other site 553199001367 homodimer interface [polypeptide binding]; other site 553199001368 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 553199001369 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 553199001370 putative active site [active] 553199001371 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 553199001372 putative active site [active] 553199001373 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 553199001374 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 553199001375 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 553199001376 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 553199001377 putative PBP binding regions; other site 553199001378 ABC-ATPase subunit interface; other site 553199001379 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 553199001380 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 553199001381 Walker A/P-loop; other site 553199001382 ATP binding site [chemical binding]; other site 553199001383 Q-loop/lid; other site 553199001384 ABC transporter signature motif; other site 553199001385 Walker B; other site 553199001386 D-loop; other site 553199001387 H-loop/switch region; other site 553199001388 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 553199001389 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 553199001390 putative ligand binding residues [chemical binding]; other site 553199001391 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 553199001392 AAA domain; Region: AAA_14; pfam13173 553199001393 Nuclease-related domain; Region: NERD; pfam08378 553199001394 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 553199001395 Precorrin-8X methylmutase; Region: CbiC; pfam02570 553199001396 cobalt transport protein CbiM; Validated; Region: PRK08319 553199001397 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 553199001398 cobalt transport protein CbiN; Provisional; Region: PRK02898 553199001399 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 553199001400 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 553199001401 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 553199001402 Walker A/P-loop; other site 553199001403 ATP binding site [chemical binding]; other site 553199001404 Q-loop/lid; other site 553199001405 ABC transporter signature motif; other site 553199001406 Walker B; other site 553199001407 D-loop; other site 553199001408 H-loop/switch region; other site 553199001409 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 553199001410 Methyltransferase domain; Region: Methyltransf_18; pfam12847 553199001411 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 553199001412 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 553199001413 homodimer interface [polypeptide binding]; other site 553199001414 Walker A motif; other site 553199001415 ATP binding site [chemical binding]; other site 553199001416 hydroxycobalamin binding site [chemical binding]; other site 553199001417 Walker B motif; other site 553199001418 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 553199001419 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 553199001420 catalytic triad [active] 553199001421 hypothetical protein; Provisional; Region: PRK07908 553199001422 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 553199001423 pyridoxal 5'-phosphate binding site [chemical binding]; other site 553199001424 homodimer interface [polypeptide binding]; other site 553199001425 catalytic residue [active] 553199001426 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 553199001427 homodimer interface [polypeptide binding]; other site 553199001428 active site 553199001429 SAM binding site [chemical binding]; other site 553199001430 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 553199001431 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 553199001432 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 553199001433 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 553199001434 putative dimer interface [polypeptide binding]; other site 553199001435 active site pocket [active] 553199001436 putative cataytic base [active] 553199001437 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 553199001438 homotrimer interface [polypeptide binding]; other site 553199001439 Walker A motif; other site 553199001440 GTP binding site [chemical binding]; other site 553199001441 Walker B motif; other site 553199001442 cobalamin synthase; Reviewed; Region: cobS; PRK00235 553199001443 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 553199001444 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 553199001445 intersubunit interface [polypeptide binding]; other site 553199001446 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 553199001447 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 553199001448 active site 553199001449 phosphorylation site [posttranslational modification] 553199001450 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 553199001451 active site 553199001452 P-loop; other site 553199001453 phosphorylation site [posttranslational modification] 553199001454 S-Ribosylhomocysteinase (LuxS); Region: LuxS; cl00802 553199001455 DDE superfamily endonuclease; Region: DDE_3; pfam13358 553199001456 S-ribosylhomocysteinase; Provisional; Region: PRK02260 553199001457 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 553199001458 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 553199001459 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 553199001460 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 553199001461 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 553199001462 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 553199001463 ring oligomerisation interface [polypeptide binding]; other site 553199001464 ATP/Mg binding site [chemical binding]; other site 553199001465 stacking interactions; other site 553199001466 hinge regions; other site 553199001467 Transaldolase; Region: Transaldolase; pfam00923 553199001468 catalytic residue [active] 553199001469 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 553199001470 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 553199001471 DNA-binding site [nucleotide binding]; DNA binding site 553199001472 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 553199001473 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 553199001474 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 553199001475 substrate binding site [chemical binding]; other site 553199001476 ATP binding site [chemical binding]; other site 553199001477 KduI/IolB family; Region: KduI; pfam04962 553199001478 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 553199001479 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 553199001480 PYR/PP interface [polypeptide binding]; other site 553199001481 dimer interface [polypeptide binding]; other site 553199001482 TPP binding site [chemical binding]; other site 553199001483 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cd00368 553199001484 molybdopterin cofactor binding site; other site 553199001485 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 553199001486 TPP-binding site; other site 553199001487 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 553199001488 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 553199001489 tetrameric interface [polypeptide binding]; other site 553199001490 NAD binding site [chemical binding]; other site 553199001491 catalytic residues [active] 553199001492 Transcriptional regulators [Transcription]; Region: PurR; COG1609 553199001493 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 553199001494 DNA binding site [nucleotide binding] 553199001495 domain linker motif; other site 553199001496 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 553199001497 dimerization interface [polypeptide binding]; other site 553199001498 ligand binding site [chemical binding]; other site 553199001499 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 553199001500 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 553199001501 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 553199001502 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 553199001503 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 553199001504 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 553199001505 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 553199001506 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 553199001507 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 553199001508 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 553199001509 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 553199001510 putative substrate translocation pore; other site 553199001511 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 553199001512 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 553199001513 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 553199001514 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 553199001515 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 553199001516 DNA interaction; other site 553199001517 Metal-binding active site; metal-binding site 553199001518 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 553199001519 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 553199001520 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 553199001521 CAAX protease self-immunity; Region: Abi; pfam02517 553199001522 CutC family; Region: CutC; cl01218 553199001523 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 553199001524 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 553199001525 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 553199001526 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 553199001527 ATP binding site [chemical binding]; other site 553199001528 putative Mg++ binding site [ion binding]; other site 553199001529 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 553199001530 nucleotide binding region [chemical binding]; other site 553199001531 ATP-binding site [chemical binding]; other site 553199001532 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 553199001533 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 553199001534 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 553199001535 active site 553199001536 trimer interface [polypeptide binding]; other site 553199001537 allosteric site; other site 553199001538 active site lid [active] 553199001539 hexamer (dimer of trimers) interface [polypeptide binding]; other site 553199001540 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 553199001541 DNA-binding site [nucleotide binding]; DNA binding site 553199001542 RNA-binding motif; other site 553199001543 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 553199001544 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 553199001545 phosphoserine aminotransferase; Provisional; Region: PRK03080 553199001546 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 553199001547 catalytic residue [active] 553199001548 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 553199001549 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 553199001550 active site 553199001551 dimer interface [polypeptide binding]; other site 553199001552 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 553199001553 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 553199001554 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 553199001555 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 553199001556 catalytic residues [active] 553199001557 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 553199001558 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 553199001559 putative substrate translocation pore; other site 553199001560 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 553199001561 Eukaryotic UGPase catalyses the synthesis of UDP-Glucose; Region: UGPase_euk; cd00897 553199001562 active site 553199001563 substrate binding site; other site 553199001564 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 553199001565 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 553199001566 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 553199001567 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 553199001568 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 553199001569 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 553199001570 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 553199001571 dimer interface [polypeptide binding]; other site 553199001572 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 553199001573 putative MPT binding site; other site 553199001574 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 553199001575 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 553199001576 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 553199001577 MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor...; Region: MoaC; cl00242 553199001578 trimer interface [polypeptide binding]; other site 553199001579 dimer interface [polypeptide binding]; other site 553199001580 putative active site [active] 553199001581 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 553199001582 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 553199001583 dimer interface [polypeptide binding]; other site 553199001584 putative functional site; other site 553199001585 putative MPT binding site; other site 553199001586 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 553199001587 MoaE homodimer interface [polypeptide binding]; other site 553199001588 MoaD interaction [polypeptide binding]; other site 553199001589 active site residues [active] 553199001590 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 553199001591 MoaE interaction surface [polypeptide binding]; other site 553199001592 MoeB interaction surface [polypeptide binding]; other site 553199001593 thiocarboxylated glycine; other site 553199001594 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 553199001595 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 553199001596 FeS/SAM binding site; other site 553199001597 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 553199001598 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 553199001599 DNA binding residues [nucleotide binding] 553199001600 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 553199001601 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 553199001602 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 553199001603 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 553199001604 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 553199001605 dimer interface [polypeptide binding]; other site 553199001606 conserved gate region; other site 553199001607 putative PBP binding loops; other site 553199001608 ABC-ATPase subunit interface; other site 553199001609 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 553199001610 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 553199001611 Walker A/P-loop; other site 553199001612 ATP binding site [chemical binding]; other site 553199001613 Q-loop/lid; other site 553199001614 ABC transporter signature motif; other site 553199001615 Walker B; other site 553199001616 D-loop; other site 553199001617 H-loop/switch region; other site 553199001618 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 553199001619 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 553199001620 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 553199001621 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 553199001622 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 553199001623 [4Fe-4S] binding site [ion binding]; other site 553199001624 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 553199001625 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 553199001626 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 553199001627 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 553199001628 molybdopterin cofactor binding site; other site 553199001629 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 553199001630 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 553199001631 putative substrate translocation pore; other site 553199001632 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 553199001633 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 553199001634 GTP binding site; other site 553199001635 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 553199001636 MPT binding site; other site 553199001637 trimer interface [polypeptide binding]; other site 553199001638 DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519 553199001639 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 553199001640 4Fe-4S binding domain; Region: Fer4; pfam00037 553199001641 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 553199001642 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 553199001643 putative [Fe4-S4] binding site [ion binding]; other site 553199001644 putative molybdopterin cofactor binding site [chemical binding]; other site 553199001645 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 553199001646 putative molybdopterin cofactor binding site; other site 553199001647 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 553199001648 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 553199001649 ATP binding site [chemical binding]; other site 553199001650 substrate interface [chemical binding]; other site 553199001651 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 553199001652 ThiS interaction site; other site 553199001653 putative active site [active] 553199001654 tetramer interface [polypeptide binding]; other site 553199001655 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 553199001656 thiS-thiF/thiG interaction site; other site 553199001657 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 553199001658 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 553199001659 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 553199001660 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 553199001661 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 553199001662 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 553199001663 Predicted methyltransferases [General function prediction only]; Region: COG0313 553199001664 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 553199001665 putative SAM binding site [chemical binding]; other site 553199001666 putative homodimer interface [polypeptide binding]; other site 553199001667 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 553199001668 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 553199001669 active site 553199001670 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 553199001671 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 553199001672 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 553199001673 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 553199001674 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 553199001675 MarR family; Region: MarR_2; cl17246 553199001676 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 553199001677 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 553199001678 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14360 553199001679 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 553199001680 Substrate binding site; other site 553199001681 Mg++ binding site; other site 553199001682 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 553199001683 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 553199001684 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 553199001685 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 553199001686 active site 553199001687 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 553199001688 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 553199001689 5S rRNA interface [nucleotide binding]; other site 553199001690 CTC domain interface [polypeptide binding]; other site 553199001691 L16 interface [polypeptide binding]; other site 553199001692 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 553199001693 putative active site [active] 553199001694 catalytic residue [active] 553199001695 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 553199001696 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 553199001697 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH6; cd08260 553199001698 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 553199001699 putative NAD(P) binding site [chemical binding]; other site 553199001700 catalytic Zn binding site [ion binding]; other site 553199001701 structural Zn binding site [ion binding]; other site 553199001702 Protease prsW family; Region: PrsW-protease; pfam13367 553199001703 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 553199001704 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 553199001705 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 553199001706 ATP binding site [chemical binding]; other site 553199001707 putative Mg++ binding site [ion binding]; other site 553199001708 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 553199001709 nucleotide binding region [chemical binding]; other site 553199001710 ATP-binding site [chemical binding]; other site 553199001711 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 553199001712 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 553199001713 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12333 553199001714 homodimer interface [polypeptide binding]; other site 553199001715 metal binding site [ion binding]; metal-binding site 553199001716 enolase; Provisional; Region: eno; PRK00077 553199001717 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 553199001718 dimer interface [polypeptide binding]; other site 553199001719 metal binding site [ion binding]; metal-binding site 553199001720 substrate binding pocket [chemical binding]; other site 553199001721 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 553199001722 Septum formation initiator; Region: DivIC; pfam04977 553199001723 Protein of unknown function (DUF501); Region: DUF501; pfam04417 553199001724 exopolyphosphatase; Region: exo_poly_only; TIGR03706 553199001725 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 553199001726 Bax inhibitor 1 like; Region: BaxI_1; cl17691 553199001727 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 553199001728 nudix motif; other site 553199001729 Predicted membrane protein [Function unknown]; Region: COG2246 553199001730 GtrA-like protein; Region: GtrA; pfam04138 553199001731 Predicted membrane protein [Function unknown]; Region: COG1297 553199001732 putative oligopeptide transporter, OPT family; Region: TIGR00733 553199001733 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 553199001734 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 553199001735 active site 553199001736 catalytic tetrad [active] 553199001737 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 553199001738 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 553199001739 Na2 binding site [ion binding]; other site 553199001740 putative substrate binding site 1 [chemical binding]; other site 553199001741 Na binding site 1 [ion binding]; other site 553199001742 putative substrate binding site 2 [chemical binding]; other site 553199001743 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 553199001744 ligand binding site [chemical binding]; other site 553199001745 active site 553199001746 UGI interface [polypeptide binding]; other site 553199001747 catalytic site [active] 553199001748 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 553199001749 Domain of unknown function DUF20; Region: UPF0118; pfam01594 553199001750 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 553199001751 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 553199001752 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 553199001753 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 553199001754 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 553199001755 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 553199001756 catalytic residues [active] 553199001757 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 553199001758 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 553199001759 catalytic residue [active] 553199001760 putative FPP diphosphate binding site; other site 553199001761 putative FPP binding hydrophobic cleft; other site 553199001762 dimer interface [polypeptide binding]; other site 553199001763 putative IPP diphosphate binding site; other site 553199001764 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 553199001765 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 553199001766 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 553199001767 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 553199001768 putative active site [active] 553199001769 PhoH-like protein; Region: PhoH; pfam02562 553199001770 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 553199001771 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 553199001772 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 553199001773 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 553199001774 generic binding surface II; other site 553199001775 generic binding surface I; other site 553199001776 potential frameshift: common BLAST hit: gi|284041045|ref|YP_003390975.1| 40-residue YVTN family beta-propeller repeat protein 553199001777 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 553199001778 Phosphoesterase family; Region: Phosphoesterase; pfam04185 553199001779 Uncharacterized conserved protein [Function unknown]; Region: COG3391 553199001780 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 553199001781 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 553199001782 RmuC family; Region: RmuC; pfam02646 553199001783 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 553199001784 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 553199001785 active site 553199001786 metal binding site [ion binding]; metal-binding site 553199001787 GTP-binding protein YchF; Reviewed; Region: PRK09601 553199001788 YchF GTPase; Region: YchF; cd01900 553199001789 G1 box; other site 553199001790 GTP/Mg2+ binding site [chemical binding]; other site 553199001791 Switch I region; other site 553199001792 G2 box; other site 553199001793 Switch II region; other site 553199001794 G3 box; other site 553199001795 G4 box; other site 553199001796 G5 box; other site 553199001797 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 553199001798 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 553199001799 putative substrate translocation pore; other site 553199001800 Major Facilitator Superfamily; Region: MFS_1; pfam07690 553199001801 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 553199001802 MarR family; Region: MarR; pfam01047 553199001803 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 553199001804 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 553199001805 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 553199001806 potential catalytic triad [active] 553199001807 conserved cys residue [active] 553199001808 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 553199001809 Spore germination protein; Region: Spore_permease; cl17796 553199001810 arginine deiminase; Provisional; Region: PRK01388 553199001811 ornithine carbamoyltransferase; Validated; Region: PRK02102 553199001812 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 553199001813 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 553199001814 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 553199001815 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 553199001816 putative substrate binding site [chemical binding]; other site 553199001817 nucleotide binding site [chemical binding]; other site 553199001818 nucleotide binding site [chemical binding]; other site 553199001819 homodimer interface [polypeptide binding]; other site 553199001820 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 553199001821 Peptidyl-tRNA hydrolase, type 2 (PTH2)_like . Peptidyl-tRNA hydrolase activity releases tRNA from the premature translation termination product peptidyl-tRNA. Two structurally different enzymes have been reported to encode such activity, Pth present in...; Region: PTH2_family; cl00869 553199001822 dimer interface [polypeptide binding]; other site 553199001823 putative active site [active] 553199001824 ACT domain; Region: ACT_6; pfam13740 553199001825 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 553199001826 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869 553199001827 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 553199001828 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 553199001829 active site 553199001830 catalytic tetrad [active] 553199001831 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 553199001832 dimer interface [polypeptide binding]; other site 553199001833 catalytic triad [active] 553199001834 peroxidatic and resolving cysteines [active] 553199001835 lysine transporter; Provisional; Region: PRK10836 553199001836 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like; cd11354 553199001837 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 553199001838 active site 553199001839 catalytic site [active] 553199001840 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 553199001841 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 553199001842 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 553199001843 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 553199001844 potential frameshift: common BLAST hit: gi|50842080|ref|YP_055307.1| putative lysophospholipase 553199001845 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 553199001846 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 553199001847 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 553199001848 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 553199001849 heterodimer interface [polypeptide binding]; other site 553199001850 substrate interaction site [chemical binding]; other site 553199001851 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 553199001852 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 553199001853 active site 553199001854 substrate binding site [chemical binding]; other site 553199001855 coenzyme B12 binding site [chemical binding]; other site 553199001856 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 553199001857 B12 binding site [chemical binding]; other site 553199001858 cobalt ligand [ion binding]; other site 553199001859 membrane ATPase/protein kinase; Provisional; Region: PRK09435 553199001860 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 553199001861 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 553199001862 Walker A; other site 553199001863 G1 box; other site 553199001864 GTP/Mg2+ binding site [chemical binding]; other site 553199001865 Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496 553199001866 active site 553199001867 catalytic triad [active] 553199001868 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 553199001869 RNA binding surface [nucleotide binding]; other site 553199001870 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 553199001871 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 553199001872 Walker A/P-loop; other site 553199001873 ATP binding site [chemical binding]; other site 553199001874 Q-loop/lid; other site 553199001875 ABC transporter signature motif; other site 553199001876 Walker B; other site 553199001877 D-loop; other site 553199001878 H-loop/switch region; other site 553199001879 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 553199001880 dimer interface [polypeptide binding]; other site 553199001881 ABC-ATPase subunit interface; other site 553199001882 putative PBP binding loops; other site 553199001883 Transcriptional regulators [Transcription]; Region: PurR; COG1609 553199001884 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 553199001885 DNA binding site [nucleotide binding] 553199001886 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 553199001887 ligand binding site [chemical binding]; other site 553199001888 dimerization interface (open form) [polypeptide binding]; other site 553199001889 dimerization interface (closed form) [polypeptide binding]; other site 553199001890 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 553199001891 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 553199001892 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 553199001893 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 553199001894 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 553199001895 dimer interface [polypeptide binding]; other site 553199001896 conserved gate region; other site 553199001897 putative PBP binding loops; other site 553199001898 ABC-ATPase subunit interface; other site 553199001899 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 553199001900 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 553199001901 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 553199001902 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 553199001903 trimer interface [polypeptide binding]; other site 553199001904 hexamer (dimer of trimers) interface [polypeptide binding]; other site 553199001905 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 553199001906 substrate binding site [chemical binding]; other site 553199001907 Mn binding site [ion binding]; other site 553199001908 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 553199001909 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 553199001910 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 553199001911 Walker A/P-loop; other site 553199001912 ATP binding site [chemical binding]; other site 553199001913 Q-loop/lid; other site 553199001914 ABC transporter signature motif; other site 553199001915 Walker B; other site 553199001916 D-loop; other site 553199001917 H-loop/switch region; other site 553199001918 FtsX-like permease family; Region: FtsX; pfam02687 553199001919 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 553199001920 dimer interface [polypeptide binding]; other site 553199001921 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 553199001922 putative PBP binding regions; other site 553199001923 ABC-ATPase subunit interface; other site 553199001924 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 553199001925 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 553199001926 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 553199001927 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 553199001928 intersubunit interface [polypeptide binding]; other site 553199001929 Isochorismatase family; Region: Isochorismatase; pfam00857 553199001930 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 553199001931 catalytic triad [active] 553199001932 conserved cis-peptide bond; other site 553199001933 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 553199001934 Na binding site [ion binding]; other site 553199001935 Proline dehydrogenase; Region: Pro_dh; cl03282 553199001936 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 553199001937 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 553199001938 Glutamate binding site [chemical binding]; other site 553199001939 NAD binding site [chemical binding]; other site 553199001940 catalytic residues [active] 553199001941 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 553199001942 L-iditol 2-dehydrogenase; Region: iditol_2_DH_like; cd08235 553199001943 putative NAD(P) binding site [chemical binding]; other site 553199001944 catalytic Zn binding site [ion binding]; other site 553199001945 dihydroxyacetone kinase; Provisional; Region: PRK14479 553199001946 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 553199001947 DAK2 domain; Region: Dak2; pfam02734 553199001948 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 553199001949 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 553199001950 active site 553199001951 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 553199001952 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 553199001953 Coenzyme A binding pocket [chemical binding]; other site 553199001954 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 553199001955 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 553199001956 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 553199001957 ligand binding site [chemical binding]; other site 553199001958 homodimer interface [polypeptide binding]; other site 553199001959 NAD(P) binding site [chemical binding]; other site 553199001960 trimer interface B [polypeptide binding]; other site 553199001961 trimer interface A [polypeptide binding]; other site 553199001962 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 553199001963 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 553199001964 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 553199001965 Ferredoxin [Energy production and conversion]; Region: COG1146 553199001966 4Fe-4S binding domain; Region: Fer4; pfam00037 553199001967 succinyldiaminopimelate transaminase; Region: DapC_actino; TIGR03539 553199001968 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 553199001969 pyridoxal 5'-phosphate binding site [chemical binding]; other site 553199001970 homodimer interface [polypeptide binding]; other site 553199001971 catalytic residue [active] 553199001972 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 553199001973 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 553199001974 putative trimer interface [polypeptide binding]; other site 553199001975 putative CoA binding site [chemical binding]; other site 553199001976 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 553199001977 Amidinotransferase; Region: Amidinotransf; cl12043 553199001978 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 553199001979 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 553199001980 metabolite-proton symporter; Region: 2A0106; TIGR00883 553199001981 putative substrate translocation pore; other site 553199001982 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 553199001983 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 553199001984 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 553199001985 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 553199001986 metal binding site [ion binding]; metal-binding site 553199001987 putative dimer interface [polypeptide binding]; other site 553199001988 DivIVA domain; Region: DivI1A_domain; TIGR03544 553199001989 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 553199001990 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 553199001991 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 553199001992 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 553199001993 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 553199001994 ligand binding site; other site 553199001995 oligomer interface; other site 553199001996 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 553199001997 dimer interface [polypeptide binding]; other site 553199001998 N-terminal domain interface [polypeptide binding]; other site 553199001999 sulfate 1 binding site; other site 553199002000 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 553199002001 S-adenosylmethionine binding site [chemical binding]; other site 553199002002 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 553199002003 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 553199002004 dimer interface [polypeptide binding]; other site 553199002005 active site 553199002006 catalytic residue [active] 553199002007 sec-independent translocase; Provisional; Region: PRK01371 553199002008 Domain of unknown function DUF59; Region: DUF59; pfam01883 553199002009 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 553199002010 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 553199002011 Walker A motif; other site 553199002012 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 553199002013 PRC-barrel domain; Region: PRC; pfam05239 553199002014 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 553199002015 MgtE intracellular N domain; Region: MgtE_N; smart00924 553199002016 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 553199002017 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 553199002018 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 553199002019 proline aminopeptidase P II; Provisional; Region: PRK10879 553199002020 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 553199002021 active site 553199002022 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 553199002023 Putative zinc ribbon domain; Region: DUF164; pfam02591 553199002024 YcfA-like protein; Region: YcfA; cl00752 553199002025 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 553199002026 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 553199002027 intersubunit interface [polypeptide binding]; other site 553199002028 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 553199002029 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 553199002030 ABC-ATPase subunit interface; other site 553199002031 dimer interface [polypeptide binding]; other site 553199002032 putative PBP binding regions; other site 553199002033 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 553199002034 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 553199002035 Walker A/P-loop; other site 553199002036 ATP binding site [chemical binding]; other site 553199002037 Q-loop/lid; other site 553199002038 ABC transporter signature motif; other site 553199002039 Walker B; other site 553199002040 D-loop; other site 553199002041 H-loop/switch region; other site 553199002042 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 553199002043 dimer interface [polypeptide binding]; other site 553199002044 [2Fe-2S] cluster binding site [ion binding]; other site 553199002045 Protein of unknown function (DUF466); Region: DUF466; cl01082 553199002046 carbon starvation protein A; Provisional; Region: PRK15015 553199002047 Carbon starvation protein CstA; Region: CstA; pfam02554 553199002048 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 553199002049 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 553199002050 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 553199002051 active site 553199002052 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 553199002053 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 553199002054 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 553199002055 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 553199002056 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 553199002057 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 553199002058 metal binding triad; other site 553199002059 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 553199002060 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 553199002061 metal binding triad; other site 553199002062 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 553199002063 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 553199002064 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 553199002065 Uncharacterized conserved protein [Function unknown]; Region: COG0327 553199002066 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 553199002067 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 553199002068 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 553199002069 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 553199002070 putative active site [active] 553199002071 glutamine synthetase, type I; Region: GlnA; TIGR00653 553199002072 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 553199002073 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 553199002074 RDD family; Region: RDD; pfam06271 553199002075 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 553199002076 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 553199002077 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 553199002078 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 553199002079 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 553199002080 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 553199002081 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 553199002082 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 553199002083 DNA-binding site [nucleotide binding]; DNA binding site 553199002084 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 553199002085 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 553199002086 active site turn [active] 553199002087 phosphorylation site [posttranslational modification] 553199002088 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 553199002089 active site turn [active] 553199002090 phosphorylation site [posttranslational modification] 553199002091 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 553199002092 HPr interaction site; other site 553199002093 glycerol kinase (GK) interaction site [polypeptide binding]; other site 553199002094 active site 553199002095 phosphorylation site [posttranslational modification] 553199002096 Protein of unknown function (DUF1440); Region: DUF1440; pfam07274 553199002097 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 553199002098 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 553199002099 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 553199002100 ABC transporter; Region: ABC_tran_2; pfam12848 553199002101 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 553199002102 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 553199002103 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 553199002104 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 553199002105 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 553199002106 Asp-box motif; other site 553199002107 catalytic site [active] 553199002108 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 553199002109 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 553199002110 Asp-box motif; other site 553199002111 catalytic site [active] 553199002112 putative sialic acid transporter; Provisional; Region: PRK03893 553199002113 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 553199002114 putative substrate translocation pore; other site 553199002115 CAMP factor (Cfa); Region: CAMP_factor; pfam07373 553199002116 lipoyl synthase; Provisional; Region: PRK05481 553199002117 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 553199002118 FeS/SAM binding site; other site 553199002119 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 553199002120 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 553199002121 metal-binding site [ion binding] 553199002122 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 553199002123 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 553199002124 motif II; other site 553199002125 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 553199002126 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 553199002127 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 553199002128 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 553199002129 E3 interaction surface; other site 553199002130 lipoyl attachment site [posttranslational modification]; other site 553199002131 e3 binding domain; Region: E3_binding; pfam02817 553199002132 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 553199002133 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 553199002134 multifunctional aminopeptidase A; Provisional; Region: PRK00913 553199002135 interface (dimer of trimers) [polypeptide binding]; other site 553199002136 Substrate-binding/catalytic site; other site 553199002137 Zn-binding sites [ion binding]; other site 553199002138 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 553199002139 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 553199002140 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 553199002141 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 553199002142 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 553199002143 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 553199002144 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 553199002145 D-pathway; other site 553199002146 Putative ubiquinol binding site [chemical binding]; other site 553199002147 Low-spin heme (heme b) binding site [chemical binding]; other site 553199002148 Putative water exit pathway; other site 553199002149 Binuclear center (heme o3/CuB) [ion binding]; other site 553199002150 K-pathway; other site 553199002151 Putative proton exit pathway; other site 553199002152 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 553199002153 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 553199002154 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 553199002155 Walker A/P-loop; other site 553199002156 ATP binding site [chemical binding]; other site 553199002157 Q-loop/lid; other site 553199002158 ABC transporter signature motif; other site 553199002159 Walker B; other site 553199002160 D-loop; other site 553199002161 H-loop/switch region; other site 553199002162 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 553199002163 NADH(P)-binding; Region: NAD_binding_10; pfam13460 553199002164 NAD(P) binding site [chemical binding]; other site 553199002165 putative active site [active] 553199002166 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 553199002167 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 553199002168 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 553199002169 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 553199002170 phosphate binding site [ion binding]; other site 553199002171 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 553199002172 active site 553199002173 DNA binding site [nucleotide binding] 553199002174 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 553199002175 heme bH binding site [chemical binding]; other site 553199002176 intrachain domain interface; other site 553199002177 heme bL binding site [chemical binding]; other site 553199002178 interchain domain interface [polypeptide binding]; other site 553199002179 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 553199002180 Qo binding site; other site 553199002181 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 553199002182 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 553199002183 iron-sulfur cluster [ion binding]; other site 553199002184 [2Fe-2S] cluster binding site [ion binding]; other site 553199002185 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 553199002186 Cytochrome c; Region: Cytochrom_C; pfam00034 553199002187 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 553199002188 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 553199002189 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 553199002190 Subunit I/III interface [polypeptide binding]; other site 553199002191 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 553199002192 active site 553199002193 phosphorylation site [posttranslational modification] 553199002194 intermolecular recognition site; other site 553199002195 dimerization interface [polypeptide binding]; other site 553199002196 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 553199002197 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304 553199002198 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 553199002199 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 553199002200 active site 553199002201 hypothetical protein; Validated; Region: PRK07883 553199002202 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 553199002203 active site 553199002204 catalytic site [active] 553199002205 substrate binding site [chemical binding]; other site 553199002206 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 553199002207 GIY-YIG motif/motif A; other site 553199002208 active site 553199002209 catalytic site [active] 553199002210 putative DNA binding site [nucleotide binding]; other site 553199002211 metal binding site [ion binding]; metal-binding site 553199002212 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 553199002213 NlpC/P60 family; Region: NLPC_P60; pfam00877 553199002214 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 553199002215 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 553199002216 nucleotide binding site [chemical binding]; other site 553199002217 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 553199002218 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 553199002219 putative acyl-acceptor binding pocket; other site 553199002220 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 553199002221 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 553199002222 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 553199002223 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 553199002224 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 553199002225 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 553199002226 EamA-like transporter family; Region: EamA; pfam00892 553199002227 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 553199002228 Catalytic domain of Protein Kinases; Region: PKc; cd00180 553199002229 active site 553199002230 ATP binding site [chemical binding]; other site 553199002231 substrate binding site [chemical binding]; other site 553199002232 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 553199002233 substrate binding site [chemical binding]; other site 553199002234 activation loop (A-loop); other site 553199002235 activation loop (A-loop); other site 553199002236 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607 553199002237 active site 553199002238 barstar interaction site; other site 553199002239 Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141 553199002240 putative RNAase interaction site [polypeptide binding]; other site 553199002241 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 553199002242 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 553199002243 substrate binding pocket [chemical binding]; other site 553199002244 chain length determination region; other site 553199002245 substrate-Mg2+ binding site; other site 553199002246 catalytic residues [active] 553199002247 aspartate-rich region 1; other site 553199002248 active site lid residues [active] 553199002249 aspartate-rich region 2; other site 553199002250 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246 553199002251 Part of AAA domain; Region: AAA_19; pfam13245 553199002252 Family description; Region: UvrD_C_2; pfam13538 553199002253 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 553199002254 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 553199002255 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 553199002256 putative dimer interface [polypeptide binding]; other site 553199002257 fructuronate transporter; Provisional; Region: PRK10034; cl15264 553199002258 Transcriptional regulators [Transcription]; Region: GntR; COG1802 553199002259 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 553199002260 DNA-binding site [nucleotide binding]; DNA binding site 553199002261 FCD domain; Region: FCD; pfam07729 553199002262 glycine dehydrogenase; Provisional; Region: PRK05367 553199002263 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 553199002264 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 553199002265 catalytic residue [active] 553199002266 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 553199002267 tetramer interface [polypeptide binding]; other site 553199002268 pyridoxal 5'-phosphate binding site [chemical binding]; other site 553199002269 catalytic residue [active] 553199002270 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 553199002271 lipoyl attachment site [posttranslational modification]; other site 553199002272 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 553199002273 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 553199002274 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 553199002275 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 553199002276 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 553199002277 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 553199002278 Protein of unknown function DUF58; Region: DUF58; pfam01882 553199002279 MoxR-like ATPases [General function prediction only]; Region: COG0714 553199002280 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 553199002281 ATP binding site [chemical binding]; other site 553199002282 Walker A motif; other site 553199002283 Walker B motif; other site 553199002284 arginine finger; other site 553199002285 cell division protein MraZ; Reviewed; Region: PRK00326 553199002286 MraZ protein; Region: MraZ; pfam02381 553199002287 MraZ protein; Region: MraZ; pfam02381 553199002288 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 553199002289 MraW methylase family; Region: Methyltransf_5; cl17771 553199002290 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 553199002291 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 553199002292 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 553199002293 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 553199002294 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 553199002295 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 553199002296 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 553199002297 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 553199002298 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 553199002299 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 553199002300 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 553199002301 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 553199002302 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 553199002303 Mg++ binding site [ion binding]; other site 553199002304 putative catalytic motif [active] 553199002305 putative substrate binding site [chemical binding]; other site 553199002306 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438 553199002307 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 553199002308 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 553199002309 cell division protein FtsW; Region: ftsW; TIGR02614 553199002310 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 553199002311 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 553199002312 active site 553199002313 homodimer interface [polypeptide binding]; other site 553199002314 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 553199002315 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 553199002316 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 553199002317 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 553199002318 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 553199002319 Cell division protein FtsQ; Region: FtsQ; pfam03799 553199002320 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 553199002321 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 553199002322 nucleotide binding site [chemical binding]; other site 553199002323 SulA interaction site; other site 553199002324 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 553199002325 Protein of unknown function (DUF552); Region: DUF552; pfam04472 553199002326 DivIVA protein; Region: DivIVA; pfam05103 553199002327 DivIVA domain; Region: DivI1A_domain; TIGR03544 553199002328 V-type ATP synthase subunit E; Provisional; Region: PRK02292 553199002329 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 553199002330 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 553199002331 lipoprotein signal peptidase; Provisional; Region: PRK14787 553199002332 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 553199002333 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 553199002334 RNA binding surface [nucleotide binding]; other site 553199002335 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 553199002336 active site 553199002337 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 553199002338 pyruvate kinase; Provisional; Region: PRK06247 553199002339 domain interfaces; other site 553199002340 active site 553199002341 CrcB-like protein; Region: CRCB; pfam02537 553199002342 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 553199002343 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 553199002344 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 553199002345 active site 553199002346 phosphorylation site [posttranslational modification] 553199002347 intermolecular recognition site; other site 553199002348 dimerization interface [polypeptide binding]; other site 553199002349 ANTAR domain; Region: ANTAR; pfam03861 553199002350 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 553199002351 CoenzymeA binding site [chemical binding]; other site 553199002352 subunit interaction site [polypeptide binding]; other site 553199002353 PHB binding site; other site 553199002354 DNA polymerase I; Provisional; Region: PRK05755 553199002355 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 553199002356 active site 553199002357 metal binding site 1 [ion binding]; metal-binding site 553199002358 putative 5' ssDNA interaction site; other site 553199002359 metal binding site 3; metal-binding site 553199002360 metal binding site 2 [ion binding]; metal-binding site 553199002361 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 553199002362 putative DNA binding site [nucleotide binding]; other site 553199002363 putative metal binding site [ion binding]; other site 553199002364 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 553199002365 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 553199002366 active site 553199002367 DNA binding site [nucleotide binding] 553199002368 catalytic site [active] 553199002369 potential frameshift: common BLAST hit: gi|50842262|ref|YP_055489.1| oxidoreductase, putative D-lactate dehydrogenase 553199002370 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 553199002371 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 553199002372 FAD binding domain; Region: FAD_binding_4; pfam01565 553199002373 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 553199002374 Hint domain; Region: Hint_2; pfam13403 553199002375 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 553199002376 active site 553199002377 putative catalytic site [active] 553199002378 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 553199002379 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 553199002380 RNA binding site [nucleotide binding]; other site 553199002381 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 553199002382 RNA binding site [nucleotide binding]; other site 553199002383 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 553199002384 RNA binding site [nucleotide binding]; other site 553199002385 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 553199002386 RNA binding site [nucleotide binding]; other site 553199002387 domain interface; other site 553199002388 Htaa; Region: HtaA; pfam04213 553199002389 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 553199002390 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 553199002391 intersubunit interface [polypeptide binding]; other site 553199002392 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 553199002393 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 553199002394 ABC-ATPase subunit interface; other site 553199002395 dimer interface [polypeptide binding]; other site 553199002396 putative PBP binding regions; other site 553199002397 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 553199002398 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 553199002399 Walker A/P-loop; other site 553199002400 ATP binding site [chemical binding]; other site 553199002401 Q-loop/lid; other site 553199002402 ABC transporter signature motif; other site 553199002403 Walker B; other site 553199002404 D-loop; other site 553199002405 H-loop/switch region; other site 553199002406 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 553199002407 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 553199002408 Walker A/P-loop; other site 553199002409 ATP binding site [chemical binding]; other site 553199002410 Q-loop/lid; other site 553199002411 ABC transporter signature motif; other site 553199002412 Walker B; other site 553199002413 D-loop; other site 553199002414 H-loop/switch region; other site 553199002415 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 553199002416 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 553199002417 Walker A/P-loop; other site 553199002418 ATP binding site [chemical binding]; other site 553199002419 Q-loop/lid; other site 553199002420 ABC transporter signature motif; other site 553199002421 Walker B; other site 553199002422 D-loop; other site 553199002423 H-loop/switch region; other site 553199002424 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 553199002425 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 553199002426 CoA-binding site [chemical binding]; other site 553199002427 ATP-binding [chemical binding]; other site 553199002428 Htaa; Region: HtaA; pfam04213 553199002429 Htaa; Region: HtaA; pfam04213 553199002430 Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081 553199002431 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 553199002432 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 553199002433 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 553199002434 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 553199002435 metal ion-dependent adhesion site (MIDAS); other site 553199002436 Domain of unknown function (DUF3479); Region: DUF3479; pfam11965 553199002437 CobN/Magnesium Chelatase; Region: CobN-Mg_chel; pfam02514 553199002438 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 553199002439 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 553199002440 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 553199002441 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 553199002442 Walker A/P-loop; other site 553199002443 ATP binding site [chemical binding]; other site 553199002444 Q-loop/lid; other site 553199002445 ABC transporter signature motif; other site 553199002446 Walker B; other site 553199002447 D-loop; other site 553199002448 H-loop/switch region; other site 553199002449 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 553199002450 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 553199002451 ABC-ATPase subunit interface; other site 553199002452 dimer interface [polypeptide binding]; other site 553199002453 putative PBP binding regions; other site 553199002454 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 553199002455 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 553199002456 intersubunit interface [polypeptide binding]; other site 553199002457 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 553199002458 Walker A/P-loop; other site 553199002459 ATP binding site [chemical binding]; other site 553199002460 Q-loop/lid; other site 553199002461 excinuclease ABC subunit B; Provisional; Region: PRK05298 553199002462 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 553199002463 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 553199002464 nucleotide binding region [chemical binding]; other site 553199002465 ATP-binding site [chemical binding]; other site 553199002466 Ultra-violet resistance protein B; Region: UvrB; pfam12344 553199002467 UvrB/uvrC motif; Region: UVR; pfam02151 553199002468 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 553199002469 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 553199002470 mycothiol-dependent maleylpyruvate isomerase; Reviewed; Region: PRK09583 553199002471 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 553199002472 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 553199002473 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 553199002474 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 553199002475 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 553199002476 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 553199002477 iron-sulfur cluster [ion binding]; other site 553199002478 [2Fe-2S] cluster binding site [ion binding]; other site 553199002479 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 553199002480 catalytic core [active] 553199002481 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 553199002482 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 553199002483 GIY-YIG motif/motif A; other site 553199002484 active site 553199002485 catalytic site [active] 553199002486 putative DNA binding site [nucleotide binding]; other site 553199002487 metal binding site [ion binding]; metal-binding site 553199002488 UvrB/uvrC motif; Region: UVR; pfam02151 553199002489 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 553199002490 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 553199002491 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 553199002492 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 553199002493 phosphate binding site [ion binding]; other site 553199002494 putative substrate binding pocket [chemical binding]; other site 553199002495 dimer interface [polypeptide binding]; other site 553199002496 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 553199002497 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 553199002498 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 553199002499 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 553199002500 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 553199002501 Phosphoglycerate kinase; Region: PGK; pfam00162 553199002502 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 553199002503 substrate binding site [chemical binding]; other site 553199002504 hinge regions; other site 553199002505 ADP binding site [chemical binding]; other site 553199002506 catalytic site [active] 553199002507 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 553199002508 triosephosphate isomerase; Provisional; Region: PRK14567 553199002509 substrate binding site [chemical binding]; other site 553199002510 dimer interface [polypeptide binding]; other site 553199002511 catalytic triad [active] 553199002512 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 553199002513 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 553199002514 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 553199002515 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 553199002516 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 553199002517 active site 553199002518 multimer interface [polypeptide binding]; other site 553199002519 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 553199002520 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 553199002521 B12 binding site [chemical binding]; other site 553199002522 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 553199002523 FeS/SAM binding site; other site 553199002524 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 553199002525 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105 553199002526 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 553199002527 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 553199002528 homodimer interface [polypeptide binding]; other site 553199002529 oligonucleotide binding site [chemical binding]; other site 553199002530 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 553199002531 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 553199002532 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 553199002533 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 553199002534 Major Facilitator Superfamily; Region: MFS_1; pfam07690 553199002535 putative substrate translocation pore; other site 553199002536 GTPase CgtA; Reviewed; Region: obgE; PRK12296 553199002537 GTP1/OBG; Region: GTP1_OBG; pfam01018 553199002538 Obg GTPase; Region: Obg; cd01898 553199002539 G1 box; other site 553199002540 GTP/Mg2+ binding site [chemical binding]; other site 553199002541 Switch I region; other site 553199002542 G2 box; other site 553199002543 G3 box; other site 553199002544 Switch II region; other site 553199002545 G4 box; other site 553199002546 G5 box; other site 553199002547 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 553199002548 gamma-glutamyl kinase; Provisional; Region: PRK05429 553199002549 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 553199002550 nucleotide binding site [chemical binding]; other site 553199002551 homotetrameric interface [polypeptide binding]; other site 553199002552 putative phosphate binding site [ion binding]; other site 553199002553 putative allosteric binding site; other site 553199002554 PUA domain; Region: PUA; pfam01472 553199002555 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 553199002556 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 553199002557 putative catalytic cysteine [active] 553199002558 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 553199002559 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 553199002560 active site 553199002561 (T/H)XGH motif; other site 553199002562 Oligomerisation domain; Region: Oligomerisation; pfam02410 553199002563 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 553199002564 catalytic core [active] 553199002565 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 553199002566 substrate binding site [chemical binding]; other site 553199002567 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 553199002568 H-loop/switch region; other site 553199002569 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 553199002570 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 553199002571 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 553199002572 potential frameshift: common BLAST hit: gi|258653625|ref|YP_003202781.1| transposase mutator type 553199002573 Transposase, Mutator family; Region: Transposase_mut; pfam00872 553199002574 Transposase, Mutator family; Region: Transposase_mut; pfam00872 553199002575 FtsX-like permease family; Region: FtsX; pfam02687 553199002576 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 553199002577 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 553199002578 Walker A/P-loop; other site 553199002579 ATP binding site [chemical binding]; other site 553199002580 Q-loop/lid; other site 553199002581 ABC transporter signature motif; other site 553199002582 Walker B; other site 553199002583 D-loop; other site 553199002584 H-loop/switch region; other site 553199002585 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 553199002586 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 553199002587 ATP binding site [chemical binding]; other site 553199002588 Mg2+ binding site [ion binding]; other site 553199002589 G-X-G motif; other site 553199002590 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 553199002591 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 553199002592 active site 553199002593 phosphorylation site [posttranslational modification] 553199002594 intermolecular recognition site; other site 553199002595 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 553199002596 DNA binding residues [nucleotide binding] 553199002597 Uncharacterized conserved protein [Function unknown]; Region: COG5441; cl02262 553199002598 Uncharacterized conserved protein [Function unknown]; Region: COG5441; cl02262 553199002599 aspartate aminotransferase; Provisional; Region: PRK05764 553199002600 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 553199002601 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 553199002602 Transposase; Region: DDE_Tnp_ISL3; pfam01610 553199002603 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 553199002604 Walker A/P-loop; other site 553199002605 ATP binding site [chemical binding]; other site 553199002606 Q-loop/lid; other site 553199002607 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 553199002608 ABC transporter signature motif; other site 553199002609 Walker B; other site 553199002610 D-loop; other site 553199002611 H-loop/switch region; other site 553199002612 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 553199002613 Walker A/P-loop; other site 553199002614 ATP binding site [chemical binding]; other site 553199002615 Q-loop/lid; other site 553199002616 ABC transporter signature motif; other site 553199002617 Walker B; other site 553199002618 D-loop; other site 553199002619 H-loop/switch region; other site 553199002620 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 553199002621 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 553199002622 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 553199002623 active site 553199002624 substrate binding pocket [chemical binding]; other site 553199002625 homodimer interaction site [polypeptide binding]; other site 553199002626 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 553199002627 active site 553199002628 dimer interface [polypeptide binding]; other site 553199002629 magnesium binding site [ion binding]; other site 553199002630 L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209 553199002631 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 553199002632 AP (apurinic/apyrimidinic) site pocket; other site 553199002633 DNA interaction; other site 553199002634 Metal-binding active site; metal-binding site 553199002635 L-ribulose-5-phosphate 4-epimerase; Validated; Region: PRK06557 553199002636 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 553199002637 intersubunit interface [polypeptide binding]; other site 553199002638 active site 553199002639 Zn2+ binding site [ion binding]; other site 553199002640 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 553199002641 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 553199002642 substrate binding site [chemical binding]; other site 553199002643 ATP binding site [chemical binding]; other site 553199002644 benzoate transport; Region: 2A0115; TIGR00895 553199002645 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 553199002646 putative substrate translocation pore; other site 553199002647 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 553199002648 substrate binding site [chemical binding]; other site 553199002649 multimerization interface [polypeptide binding]; other site 553199002650 ATP binding site [chemical binding]; other site 553199002651 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 553199002652 thiamine phosphate binding site [chemical binding]; other site 553199002653 active site 553199002654 pyrophosphate binding site [ion binding]; other site 553199002655 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 553199002656 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 553199002657 dimer interface [polypeptide binding]; other site 553199002658 NAD binding site [chemical binding]; other site 553199002659 substrate binding site [chemical binding]; other site 553199002660 tetramer (dimer of dimers) interface [polypeptide binding]; other site 553199002661 malate dehydrogenase; Provisional; Region: PRK13529 553199002662 Malic enzyme, N-terminal domain; Region: malic; pfam00390 553199002663 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 553199002664 NAD(P) binding pocket [chemical binding]; other site 553199002665 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 553199002666 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 553199002667 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 553199002668 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 553199002669 HIGH motif; other site 553199002670 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 553199002671 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 553199002672 active site 553199002673 KMSKS motif; other site 553199002674 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 553199002675 tRNA binding surface [nucleotide binding]; other site 553199002676 SLBB domain; Region: SLBB; pfam10531 553199002677 comEA protein; Region: comE; TIGR01259 553199002678 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 553199002679 Competence protein; Region: Competence; pfam03772 553199002680 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 553199002681 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 553199002682 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 553199002683 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 553199002684 ATP binding site [chemical binding]; other site 553199002685 putative Mg++ binding site [ion binding]; other site 553199002686 hypothetical protein; Reviewed; Region: PRK07914 553199002687 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 553199002688 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 553199002689 Alpha amylase catalytic domain found in Amylosucrase; Region: AmyAc_Amylosucrase; cd11324 553199002690 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 553199002691 active site 553199002692 catalytic site [active] 553199002693 GTP-binding protein LepA; Provisional; Region: PRK05433 553199002694 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 553199002695 G1 box; other site 553199002696 putative GEF interaction site [polypeptide binding]; other site 553199002697 GTP/Mg2+ binding site [chemical binding]; other site 553199002698 Switch I region; other site 553199002699 G2 box; other site 553199002700 G3 box; other site 553199002701 Switch II region; other site 553199002702 G4 box; other site 553199002703 G5 box; other site 553199002704 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 553199002705 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 553199002706 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 553199002707 O-succinylbenzoate synthase; Provisional; Region: PRK02901 553199002708 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 553199002709 active site 553199002710 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase; Region: menD; TIGR00173 553199002711 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 553199002712 dimer interface [polypeptide binding]; other site 553199002713 tetramer interface [polypeptide binding]; other site 553199002714 PYR/PP interface [polypeptide binding]; other site 553199002715 TPP binding site [chemical binding]; other site 553199002716 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 553199002717 TPP-binding site [chemical binding]; other site 553199002718 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 553199002719 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 553199002720 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 553199002721 acyl-activating enzyme (AAE) consensus motif; other site 553199002722 AMP binding site [chemical binding]; other site 553199002723 active site 553199002724 CoA binding site [chemical binding]; other site 553199002725 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 553199002726 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 553199002727 substrate binding site [chemical binding]; other site 553199002728 oxyanion hole (OAH) forming residues; other site 553199002729 trimer interface [polypeptide binding]; other site 553199002730 Rhomboid family; Region: Rhomboid; pfam01694 553199002731 potential frameshift: common BLAST hit: gi|153006304|ref|YP_001380629.1| acetate--CoA ligase 553199002732 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 553199002733 potential frameshift: common BLAST hit: gi|220918635|ref|YP_002493939.1| acetate/CoA ligase 553199002734 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 553199002735 acyl-activating enzyme (AAE) consensus motif; other site 553199002736 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 553199002737 AMP binding site [chemical binding]; other site 553199002738 active site 553199002739 CoA binding site [chemical binding]; other site 553199002740 coproporphyrinogen III oxidase; Validated; Region: PRK05628 553199002741 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 553199002742 FeS/SAM binding site; other site 553199002743 HemN C-terminal domain; Region: HemN_C; pfam06969 553199002744 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 553199002745 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 553199002746 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 553199002747 active site 553199002748 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 553199002749 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 553199002750 chaperone protein DnaJ; Provisional; Region: PRK14278 553199002751 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 553199002752 HSP70 interaction site [polypeptide binding]; other site 553199002753 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 553199002754 Zn binding sites [ion binding]; other site 553199002755 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 553199002756 dimer interface [polypeptide binding]; other site 553199002757 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 553199002758 RNA methyltransferase, RsmE family; Region: TIGR00046 553199002759 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 553199002760 L-iditol 2-dehydrogenase; Region: iditol_2_DH_like; cd08235 553199002761 putative NAD(P) binding site [chemical binding]; other site 553199002762 catalytic Zn binding site [ion binding]; other site 553199002763 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 553199002764 active site 553199002765 phosphorylation site [posttranslational modification] 553199002766 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 553199002767 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 553199002768 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 553199002769 active site 553199002770 P-loop; other site 553199002771 phosphorylation site [posttranslational modification] 553199002772 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 553199002773 active site 553199002774 Predicted membrane protein [Function unknown]; Region: COG2259 553199002775 DEAD-like helicases superfamily; Region: DEXDc; smart00487 553199002776 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 553199002777 ATP binding site [chemical binding]; other site 553199002778 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 553199002779 putative Mg++ binding site [ion binding]; other site 553199002780 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 553199002781 nucleotide binding region [chemical binding]; other site 553199002782 ATP-binding site [chemical binding]; other site 553199002783 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 553199002784 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 553199002785 EamA-like transporter family; Region: EamA; pfam00892 553199002786 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 553199002787 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 553199002788 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 553199002789 Histidine kinase; Region: HisKA_3; pfam07730 553199002790 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 553199002791 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 553199002792 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 553199002793 active site 553199002794 phosphorylation site [posttranslational modification] 553199002795 intermolecular recognition site; other site 553199002796 dimerization interface [polypeptide binding]; other site 553199002797 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 553199002798 DNA binding residues [nucleotide binding] 553199002799 dimerization interface [polypeptide binding]; other site 553199002800 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 553199002801 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 553199002802 Walker A/P-loop; other site 553199002803 ATP binding site [chemical binding]; other site 553199002804 Q-loop/lid; other site 553199002805 ABC transporter signature motif; other site 553199002806 Walker B; other site 553199002807 D-loop; other site 553199002808 H-loop/switch region; other site 553199002809 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 553199002810 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 553199002811 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 553199002812 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 553199002813 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 553199002814 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 553199002815 PhoH-like protein; Region: PhoH; pfam02562 553199002816 metal-binding heat shock protein; Provisional; Region: PRK00016 553199002817 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 553199002818 Domain of unknown function DUF21; Region: DUF21; pfam01595 553199002819 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 553199002820 Transporter associated domain; Region: CorC_HlyC; smart01091 553199002821 GTPase Era; Reviewed; Region: era; PRK00089 553199002822 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 553199002823 G1 box; other site 553199002824 GTP/Mg2+ binding site [chemical binding]; other site 553199002825 Switch I region; other site 553199002826 G2 box; other site 553199002827 Switch II region; other site 553199002828 G3 box; other site 553199002829 G4 box; other site 553199002830 G5 box; other site 553199002831 KH domain; Region: KH_2; pfam07650 553199002832 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 553199002833 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 553199002834 active site 553199002835 2-isopropylmalate synthase; Validated; Region: PRK03739 553199002836 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 553199002837 active site 553199002838 catalytic residues [active] 553199002839 metal binding site [ion binding]; metal-binding site 553199002840 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 553199002841 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 553199002842 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 553199002843 catalytic residue [active] 553199002844 putative FPP diphosphate binding site; other site 553199002845 putative FPP binding hydrophobic cleft; other site 553199002846 dimer interface [polypeptide binding]; other site 553199002847 putative IPP diphosphate binding site; other site 553199002848 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 553199002849 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 553199002850 Recombination protein O N terminal; Region: RecO_N; pfam11967 553199002851 Recombination protein O C terminal; Region: RecO_C; pfam02565 553199002852 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 553199002853 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 553199002854 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 553199002855 active site 553199002856 phosphorylation site [posttranslational modification] 553199002857 intermolecular recognition site; other site 553199002858 dimerization interface [polypeptide binding]; other site 553199002859 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 553199002860 DNA binding residues [nucleotide binding] 553199002861 dimerization interface [polypeptide binding]; other site 553199002862 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 553199002863 metal binding site 2 [ion binding]; metal-binding site 553199002864 putative DNA binding helix; other site 553199002865 metal binding site 1 [ion binding]; metal-binding site 553199002866 dimer interface [polypeptide binding]; other site 553199002867 structural Zn2+ binding site [ion binding]; other site 553199002868 glycyl-tRNA synthetase; Provisional; Region: PRK04173 553199002869 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 553199002870 motif 1; other site 553199002871 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 553199002872 active site 553199002873 motif 2; other site 553199002874 motif 3; other site 553199002875 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 553199002876 anticodon binding site; other site 553199002877 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 553199002878 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 553199002879 proximal heme binding site [chemical binding]; other site 553199002880 distal heme binding site [chemical binding]; other site 553199002881 putative dimer interface [polypeptide binding]; other site 553199002882 putative Iron-sulfur protein interface [polypeptide binding]; other site 553199002883 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 553199002884 L-aspartate oxidase; Provisional; Region: PRK06175 553199002885 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 553199002886 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 553199002887 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 553199002888 4Fe-4S binding domain; Region: Fer4; pfam00037 553199002889 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 553199002890 putative FMN binding site [chemical binding]; other site 553199002891 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 553199002892 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 553199002893 putative dimer interface [polypeptide binding]; other site 553199002894 active site pocket [active] 553199002895 putative cataytic base [active] 553199002896 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 553199002897 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 553199002898 FMN binding site [chemical binding]; other site 553199002899 active site 553199002900 catalytic residues [active] 553199002901 substrate binding site [chemical binding]; other site 553199002902 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 553199002903 Zn2+ binding site [ion binding]; other site 553199002904 Mg2+ binding site [ion binding]; other site 553199002905 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 553199002906 Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424 553199002907 DNA primase; Validated; Region: dnaG; PRK05667 553199002908 CHC2 zinc finger; Region: zf-CHC2; pfam01807 553199002909 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 553199002910 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 553199002911 active site 553199002912 metal binding site [ion binding]; metal-binding site 553199002913 interdomain interaction site; other site 553199002914 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 553199002915 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 553199002916 DNA-directed RNA polymerase specialized sigma subunit [Transcription]; Region: FliA; COG1191 553199002917 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 553199002918 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 553199002919 DNA binding residues [nucleotide binding] 553199002920 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 553199002921 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 553199002922 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 553199002923 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 553199002924 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 553199002925 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 553199002926 active site 553199002927 homotetramer interface [polypeptide binding]; other site 553199002928 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 553199002929 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 553199002930 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 553199002931 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 553199002932 dimer interface [polypeptide binding]; other site 553199002933 pyridoxal 5'-phosphate binding site [chemical binding]; other site 553199002934 catalytic residue [active] 553199002935 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 553199002936 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 553199002937 DNA-binding site [nucleotide binding]; DNA binding site 553199002938 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 553199002939 pyridoxal 5'-phosphate binding site [chemical binding]; other site 553199002940 homodimer interface [polypeptide binding]; other site 553199002941 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 553199002942 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 553199002943 active site 553199002944 multimer interface [polypeptide binding]; other site 553199002945 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 553199002946 predicted active site [active] 553199002947 catalytic triad [active] 553199002948 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 553199002949 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 553199002950 inhibitor-cofactor binding pocket; inhibition site 553199002951 pyridoxal 5'-phosphate binding site [chemical binding]; other site 553199002952 catalytic residue [active] 553199002953 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 553199002954 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 553199002955 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 553199002956 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 553199002957 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 553199002958 active site 553199002959 motif I; other site 553199002960 motif II; other site 553199002961 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 553199002962 MoxR-like ATPases [General function prediction only]; Region: COG0714 553199002963 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 553199002964 Walker A motif; other site 553199002965 ATP binding site [chemical binding]; other site 553199002966 Walker B motif; other site 553199002967 arginine finger; other site 553199002968 Protein of unknown function DUF58; Region: DUF58; pfam01882 553199002969 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 553199002970 hypothetical protein; Provisional; Region: PRK13685 553199002971 von Willebrand factor type A domain; Region: VWA_2; pfam13519 553199002972 metal ion-dependent adhesion site (MIDAS); other site 553199002973 Protein-interacting Bro1-like domain of mammalian Alix and related domains; Region: BRO1_Alix_like; cl14649 553199002974 von Willebrand factor type A domain; Region: VWA_2; pfam13519 553199002975 metal ion-dependent adhesion site (MIDAS); other site 553199002976 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 553199002977 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 553199002978 catalytic residue [active] 553199002979 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 553199002980 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 553199002981 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 553199002982 dimer interface [polypeptide binding]; other site 553199002983 active site 553199002984 acyl carrier protein; Provisional; Region: acpP; PRK00982 553199002985 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 553199002986 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 553199002987 dimer interface [polypeptide binding]; other site 553199002988 active site 553199002989 CoA binding pocket [chemical binding]; other site 553199002990 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 553199002991 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 553199002992 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 553199002993 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cl00252 553199002994 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 553199002995 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 553199002996 putative substrate translocation pore; other site 553199002997 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 553199002998 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 553199002999 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 553199003000 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 553199003001 dimer interface [polypeptide binding]; other site 553199003002 TPP-binding site [chemical binding]; other site 553199003003 Endo-beta-N-acetylglucosaminidases are bacterial chitinases that hydrolyze the chitin core of various asparagine (N)-linked glycans and glycoproteins. The endo-beta-N-acetylglucosaminidases have a glycosyl hydrolase family 18 (GH18) catalytic domain; Region: GH18_EndoS-like; cd06542 553199003004 active site 553199003005 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 553199003006 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 553199003007 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 553199003008 Isochorismatase family; Region: Isochorismatase; pfam00857 553199003009 catalytic triad [active] 553199003010 metal binding site [ion binding]; metal-binding site 553199003011 conserved cis-peptide bond; other site 553199003012 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 553199003013 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 553199003014 active site 553199003015 catalytic tetrad [active] 553199003016 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 553199003017 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 553199003018 active site 553199003019 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 553199003020 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 553199003021 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 553199003022 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 553199003023 dihydroorotase; Validated; Region: pyrC; PRK09357 553199003024 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 553199003025 active site 553199003026 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 553199003027 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 553199003028 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 553199003029 catalytic site [active] 553199003030 subunit interface [polypeptide binding]; other site 553199003031 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 553199003032 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 553199003033 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 553199003034 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 553199003035 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 553199003036 ATP-grasp domain; Region: ATP-grasp_4; cl17255 553199003037 MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245 553199003038 substrate binding site [chemical binding]; other site 553199003039 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 553199003040 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 553199003041 FAD binding pocket [chemical binding]; other site 553199003042 FAD binding motif [chemical binding]; other site 553199003043 phosphate binding motif [ion binding]; other site 553199003044 beta-alpha-beta structure motif; other site 553199003045 NAD binding pocket [chemical binding]; other site 553199003046 Iron coordination center [ion binding]; other site 553199003047 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 553199003048 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 553199003049 heterodimer interface [polypeptide binding]; other site 553199003050 active site 553199003051 FMN binding site [chemical binding]; other site 553199003052 homodimer interface [polypeptide binding]; other site 553199003053 substrate binding site [chemical binding]; other site 553199003054 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 553199003055 active site 553199003056 dimer interface [polypeptide binding]; other site 553199003057 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 553199003058 active site 553199003059 Fructosamine kinase; Region: Fructosamin_kin; cl17579 553199003060 Phosphotransferase enzyme family; Region: APH; pfam01636 553199003061 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 553199003062 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 553199003063 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 553199003064 Competence-damaged protein; Region: CinA; pfam02464 553199003065 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 553199003066 non-specific DNA binding site [nucleotide binding]; other site 553199003067 salt bridge; other site 553199003068 sequence-specific DNA binding site [nucleotide binding]; other site 553199003069 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 553199003070 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 553199003071 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 553199003072 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 553199003073 recombinase A; Provisional; Region: recA; PRK09354 553199003074 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 553199003075 hexamer interface [polypeptide binding]; other site 553199003076 Walker A motif; other site 553199003077 ATP binding site [chemical binding]; other site 553199003078 Walker B motif; other site 553199003079 recombination regulator RecX; Reviewed; Region: recX; PRK00117 553199003080 hypothetical protein; Provisional; Region: PRK12705 553199003081 KH domain; Region: KH_1; pfam00013 553199003082 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 553199003083 Zn2+ binding site [ion binding]; other site 553199003084 Mg2+ binding site [ion binding]; other site 553199003085 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 553199003086 active site 553199003087 catalytic residues [active] 553199003088 Predicted membrane protein [Function unknown]; Region: COG1288 553199003089 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 553199003090 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 553199003091 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 553199003092 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 553199003093 FeS/SAM binding site; other site 553199003094 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 553199003095 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 553199003096 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 553199003097 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 553199003098 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 553199003099 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 553199003100 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 553199003101 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 553199003102 HflX GTPase family; Region: HflX; cd01878 553199003103 G1 box; other site 553199003104 GTP/Mg2+ binding site [chemical binding]; other site 553199003105 Switch I region; other site 553199003106 G2 box; other site 553199003107 G3 box; other site 553199003108 Switch II region; other site 553199003109 G4 box; other site 553199003110 G5 box; other site 553199003111 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 553199003112 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 553199003113 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 553199003114 putative Mg++ binding site [ion binding]; other site 553199003115 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 553199003116 LexA repressor; Validated; Region: PRK00215 553199003117 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 553199003118 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 553199003119 Catalytic site [active] 553199003120 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 553199003121 ATP cone domain; Region: ATP-cone; pfam03477 553199003122 vitamin B12-dependent ribonucleotide reductase; Validated; Region: PRK06556 553199003123 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 553199003124 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 553199003125 active site 553199003126 dimer interface [polypeptide binding]; other site 553199003127 effector binding site; other site 553199003128 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 553199003129 TSCPD domain; Region: TSCPD; pfam12637 553199003130 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 553199003131 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 553199003132 Ligand Binding Site [chemical binding]; other site 553199003133 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 553199003134 Ligand Binding Site [chemical binding]; other site 553199003135 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 553199003136 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 553199003137 ATP binding site [chemical binding]; other site 553199003138 putative Mg++ binding site [ion binding]; other site 553199003139 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 553199003140 nucleotide binding region [chemical binding]; other site 553199003141 ATP-binding site [chemical binding]; other site 553199003142 Helicase associated domain (HA2); Region: HA2; pfam04408 553199003143 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 553199003144 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 553199003145 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 553199003146 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 553199003147 active site 553199003148 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 553199003149 catalytic triad [active] 553199003150 dimer interface [polypeptide binding]; other site 553199003151 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 553199003152 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 553199003153 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 553199003154 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 553199003155 Sigma-70, region 4; Region: Sigma70_r4; pfam04545 553199003156 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 553199003157 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 553199003158 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 553199003159 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 553199003160 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 553199003161 DNA binding residues [nucleotide binding] 553199003162 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 553199003163 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 553199003164 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 553199003165 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 553199003166 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 553199003167 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 553199003168 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 553199003169 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 553199003170 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 553199003171 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 553199003172 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 553199003173 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 553199003174 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 553199003175 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 553199003176 Mg2+ binding site [ion binding]; other site 553199003177 G-X-G motif; other site 553199003178 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 553199003179 anchoring element; other site 553199003180 dimer interface [polypeptide binding]; other site 553199003181 ATP binding site [chemical binding]; other site 553199003182 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 553199003183 active site 553199003184 metal binding site [ion binding]; metal-binding site 553199003185 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 553199003186 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 553199003187 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 553199003188 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 553199003189 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 553199003190 putative substrate translocation pore; other site 553199003191 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 553199003192 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 553199003193 CAP-like domain; other site 553199003194 active site 553199003195 primary dimer interface [polypeptide binding]; other site 553199003196 Uncharacterized conserved protein [Function unknown]; Region: COG4850 553199003197 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 553199003198 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 553199003199 Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; cl17415 553199003200 thymidine kinase; Provisional; Region: PRK04296 553199003201 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 553199003202 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 553199003203 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 553199003204 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 553199003205 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 553199003206 trimer interface [polypeptide binding]; other site 553199003207 active site 553199003208 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 553199003209 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 553199003210 ssDNA binding site; other site 553199003211 generic binding surface II; other site 553199003212 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 553199003213 TrkA-N domain; Region: TrkA_N; pfam02254 553199003214 TrkA-C domain; Region: TrkA_C; pfam02080 553199003215 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 553199003216 TrkA-N domain; Region: TrkA_N; pfam02254 553199003217 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 553199003218 TRAM domain; Region: TRAM; cl01282 553199003219 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 553199003220 aconitate hydratase; Validated; Region: PRK09277 553199003221 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 553199003222 substrate binding site [chemical binding]; other site 553199003223 ligand binding site [chemical binding]; other site 553199003224 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 553199003225 substrate binding site [chemical binding]; other site 553199003226 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 553199003227 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 553199003228 TPP-binding site; other site 553199003229 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 553199003230 PYR/PP interface [polypeptide binding]; other site 553199003231 dimer interface [polypeptide binding]; other site 553199003232 TPP binding site [chemical binding]; other site 553199003233 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 553199003234 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 553199003235 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 553199003236 catalytic site [active] 553199003237 putative active site [active] 553199003238 putative substrate binding site [chemical binding]; other site 553199003239 HRDC domain; Region: HRDC; pfam00570 553199003240 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 553199003241 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 553199003242 SelR domain; Region: SelR; pfam01641 553199003243 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 553199003244 active site 553199003245 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 553199003246 YheO-like PAS domain; Region: PAS_6; pfam08348 553199003247 HTH domain; Region: HTH_22; pfam13309 553199003248 tryptophanase/L-cysteine desulfhydrase, PLP-dependent; Provisional; Region: tnaA; PRK13238 553199003249 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 553199003250 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 553199003251 catalytic residue [active] 553199003252 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 553199003253 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 553199003254 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 553199003255 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 553199003256 putative NAD(P) binding site [chemical binding]; other site 553199003257 putative substrate binding site [chemical binding]; other site 553199003258 catalytic Zn binding site [ion binding]; other site 553199003259 structural Zn binding site [ion binding]; other site 553199003260 dimer interface [polypeptide binding]; other site 553199003261 LrgB-like family; Region: LrgB; cl00596 553199003262 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 553199003263 Histidine kinase; Region: HisKA_3; pfam07730 553199003264 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 553199003265 ATP binding site [chemical binding]; other site 553199003266 Mg2+ binding site [ion binding]; other site 553199003267 G-X-G motif; other site 553199003268 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 553199003269 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 553199003270 active site 553199003271 phosphorylation site [posttranslational modification] 553199003272 intermolecular recognition site; other site 553199003273 dimerization interface [polypeptide binding]; other site 553199003274 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 553199003275 DNA binding residues [nucleotide binding] 553199003276 dimerization interface [polypeptide binding]; other site 553199003277 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 553199003278 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 553199003279 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 553199003280 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 553199003281 active site 553199003282 dimer interface [polypeptide binding]; other site 553199003283 motif 1; other site 553199003284 motif 2; other site 553199003285 motif 3; other site 553199003286 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 553199003287 anticodon binding site; other site 553199003288 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 553199003289 nucleotide binding site/active site [active] 553199003290 HIT family signature motif; other site 553199003291 catalytic residue [active] 553199003292 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 553199003293 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 553199003294 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 553199003295 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 553199003296 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 553199003297 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 553199003298 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 553199003299 lipoyl attachment site [posttranslational modification]; other site 553199003300 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 553199003301 Double zinc ribbon; Region: DZR; pfam12773 553199003302 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 553199003303 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 553199003304 phosphopeptide binding site; other site 553199003305 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 553199003306 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 553199003307 DNA binding residues [nucleotide binding] 553199003308 Bifunctional nuclease; Region: DNase-RNase; pfam02577 553199003309 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 553199003310 DNA binding residues [nucleotide binding] 553199003311 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 553199003312 putative dimer interface [polypeptide binding]; other site 553199003313 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 553199003314 Major Facilitator Superfamily; Region: MFS_1; pfam07690 553199003315 pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated; Region: PRK06555 553199003316 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 553199003317 active site 553199003318 ADP/pyrophosphate binding site [chemical binding]; other site 553199003319 fructose-1,6-bisphosphate binding site; other site 553199003320 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 553199003321 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 553199003322 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 553199003323 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 553199003324 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 553199003325 Uncharacterized conserved protein [Function unknown]; Region: COG1739 553199003326 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 553199003327 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 553199003328 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 553199003329 PAC2 family; Region: PAC2; pfam09754 553199003330 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 553199003331 active site 553199003332 acyl-CoA esterase; Provisional; Region: PRK10673 553199003333 hypothetical protein; Provisional; Region: PRK03298 553199003334 DivIVA protein; Region: DivIVA; pfam05103 553199003335 V-type ATP synthase subunit E; Provisional; Region: PRK01558 553199003336 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 553199003337 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 553199003338 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 553199003339 dimer interface [polypeptide binding]; other site 553199003340 substrate binding site [chemical binding]; other site 553199003341 metal binding site [ion binding]; metal-binding site 553199003342 phosphoglucomutase; Validated; Region: PRK07564 553199003343 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 553199003344 active site 553199003345 substrate binding site [chemical binding]; other site 553199003346 metal binding site [ion binding]; metal-binding site 553199003347 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 553199003348 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 553199003349 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 553199003350 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 553199003351 motif II; other site 553199003352 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 553199003353 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 553199003354 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 553199003355 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 553199003356 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 553199003357 active site turn [active] 553199003358 phosphorylation site [posttranslational modification] 553199003359 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 553199003360 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 553199003361 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 553199003362 HPr interaction site; other site 553199003363 glycerol kinase (GK) interaction site [polypeptide binding]; other site 553199003364 active site 553199003365 phosphorylation site [posttranslational modification] 553199003366 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 553199003367 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 553199003368 nudix motif; other site 553199003369 glycogen branching enzyme; Provisional; Region: PRK12313 553199003370 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 553199003371 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 553199003372 active site 553199003373 catalytic site [active] 553199003374 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 553199003375 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 553199003376 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 553199003377 trehalose synthase; Region: treS_nterm; TIGR02456 553199003378 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 553199003379 active site 553199003380 catalytic site [active] 553199003381 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 553199003382 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 553199003383 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 553199003384 active site 553199003385 homodimer interface [polypeptide binding]; other site 553199003386 catalytic site [active] 553199003387 acceptor binding site [chemical binding]; other site 553199003388 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 553199003389 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 553199003390 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 553199003391 active site 553199003392 catalytic site [active] 553199003393 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 553199003394 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 553199003395 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 553199003396 catalytic residue [active] 553199003397 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 553199003398 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 553199003399 Ligand Binding Site [chemical binding]; other site 553199003400 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 553199003401 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 553199003402 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 553199003403 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 553199003404 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 553199003405 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 553199003406 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 553199003407 GatB domain; Region: GatB_Yqey; smart00845 553199003408 TIGR03085 family protein; Region: TIGR03085 553199003409 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 553199003410 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 553199003411 anthranilate synthase component I; Provisional; Region: PRK13571 553199003412 anthranilate synthase component I; Provisional; Region: PRK13571 553199003413 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; cl17850 553199003414 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 553199003415 active site 553199003416 ribulose/triose binding site [chemical binding]; other site 553199003417 phosphate binding site [ion binding]; other site 553199003418 substrate (anthranilate) binding pocket [chemical binding]; other site 553199003419 product (indole) binding pocket [chemical binding]; other site 553199003420 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 553199003421 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 553199003422 pyridoxal 5'-phosphate binding site [chemical binding]; other site 553199003423 catalytic residue [active] 553199003424 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 553199003425 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 553199003426 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 553199003427 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 553199003428 active site 553199003429 dimer interface [polypeptide binding]; other site 553199003430 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 553199003431 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 553199003432 active site 553199003433 FMN binding site [chemical binding]; other site 553199003434 substrate binding site [chemical binding]; other site 553199003435 3Fe-4S cluster binding site [ion binding]; other site 553199003436 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 553199003437 domain interface; other site 553199003438 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 553199003439 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 553199003440 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 553199003441 Beta-lactamase; Region: Beta-lactamase; cl17358 553199003442 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 553199003443 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 553199003444 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 553199003445 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 553199003446 putative active site [active] 553199003447 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 553199003448 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 553199003449 putative active site [active] 553199003450 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 553199003451 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 553199003452 active site turn [active] 553199003453 phosphorylation site [posttranslational modification] 553199003454 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 553199003455 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 553199003456 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 553199003457 beta-galactosidase; Region: BGL; TIGR03356 553199003458 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 553199003459 active site 553199003460 P-loop; other site 553199003461 phosphorylation site [posttranslational modification] 553199003462 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 553199003463 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 553199003464 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 553199003465 methionine cluster; other site 553199003466 active site 553199003467 phosphorylation site [posttranslational modification] 553199003468 metal binding site [ion binding]; metal-binding site 553199003469 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 553199003470 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 553199003471 active site 553199003472 PHP Thumb interface [polypeptide binding]; other site 553199003473 metal binding site [ion binding]; metal-binding site 553199003474 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 553199003475 generic binding surface II; other site 553199003476 generic binding surface I; other site 553199003477 histidinol dehydrogenase; Region: hisD; TIGR00069 553199003478 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 553199003479 NAD binding site [chemical binding]; other site 553199003480 dimerization interface [polypeptide binding]; other site 553199003481 product binding site; other site 553199003482 substrate binding site [chemical binding]; other site 553199003483 zinc binding site [ion binding]; other site 553199003484 catalytic residues [active] 553199003485 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 553199003486 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 553199003487 pyridoxal 5'-phosphate binding site [chemical binding]; other site 553199003488 homodimer interface [polypeptide binding]; other site 553199003489 catalytic residue [active] 553199003490 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 553199003491 putative active site pocket [active] 553199003492 4-fold oligomerization interface [polypeptide binding]; other site 553199003493 metal binding residues [ion binding]; metal-binding site 553199003494 3-fold/trimer interface [polypeptide binding]; other site 553199003495 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 553199003496 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 553199003497 putative active site [active] 553199003498 oxyanion strand; other site 553199003499 catalytic triad [active] 553199003500 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 553199003501 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 553199003502 catalytic residues [active] 553199003503 hypothetical protein; Validated; Region: PRK00110 553199003504 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 553199003505 active site 553199003506 putative DNA-binding cleft [nucleotide binding]; other site 553199003507 dimer interface [polypeptide binding]; other site 553199003508 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 553199003509 RuvA N terminal domain; Region: RuvA_N; pfam01330 553199003510 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 553199003511 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 553199003512 Walker A motif; other site 553199003513 ATP binding site [chemical binding]; other site 553199003514 Walker B motif; other site 553199003515 arginine finger; other site 553199003516 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 553199003517 Preprotein translocase subunit; Region: YajC; pfam02699 553199003518 Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342 553199003519 Protein export membrane protein; Region: SecD_SecF; cl14618 553199003520 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 553199003521 Protein export membrane protein; Region: SecD_SecF; pfam02355 553199003522 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 553199003523 active site 553199003524 Ion channel; Region: Ion_trans_2; pfam07885 553199003525 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 553199003526 TrkA-N domain; Region: TrkA_N; pfam02254 553199003527 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 553199003528 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 553199003529 Zn2+ binding site [ion binding]; other site 553199003530 Mg2+ binding site [ion binding]; other site 553199003531 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 553199003532 synthetase active site [active] 553199003533 NTP binding site [chemical binding]; other site 553199003534 metal binding site [ion binding]; metal-binding site 553199003535 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 553199003536 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 553199003537 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 553199003538 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 553199003539 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 553199003540 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 553199003541 histidyl-tRNA synthetase; Region: hisS; TIGR00442 553199003542 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 553199003543 dimer interface [polypeptide binding]; other site 553199003544 motif 1; other site 553199003545 active site 553199003546 motif 2; other site 553199003547 motif 3; other site 553199003548 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 553199003549 anticodon binding site; other site 553199003550 Protein of unknown function (DUF998); Region: DUF998; pfam06197 553199003551 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 553199003552 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 553199003553 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 553199003554 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 553199003555 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 553199003556 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 553199003557 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 553199003558 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 553199003559 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 553199003560 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 553199003561 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 553199003562 dimer interface [polypeptide binding]; other site 553199003563 anticodon binding site; other site 553199003564 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 553199003565 homodimer interface [polypeptide binding]; other site 553199003566 motif 1; other site 553199003567 active site 553199003568 motif 2; other site 553199003569 GAD domain; Region: GAD; pfam02938 553199003570 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 553199003571 active site 553199003572 motif 3; other site 553199003573 recombination factor protein RarA; Reviewed; Region: PRK13342 553199003574 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 553199003575 Walker A motif; other site 553199003576 ATP binding site [chemical binding]; other site 553199003577 Walker B motif; other site 553199003578 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 553199003579 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 553199003580 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 553199003581 motif 1; other site 553199003582 active site 553199003583 motif 2; other site 553199003584 motif 3; other site 553199003585 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 553199003586 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 553199003587 YceG-like family; Region: YceG; pfam02618 553199003588 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 553199003589 dimerization interface [polypeptide binding]; other site 553199003590 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 553199003591 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 553199003592 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 553199003593 shikimate binding site; other site 553199003594 NAD(P) binding site [chemical binding]; other site 553199003595 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 553199003596 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 553199003597 Tetramer interface [polypeptide binding]; other site 553199003598 active site 553199003599 FMN-binding site [chemical binding]; other site 553199003600 shikimate kinase; Reviewed; Region: aroK; PRK00131 553199003601 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 553199003602 ADP binding site [chemical binding]; other site 553199003603 magnesium binding site [ion binding]; other site 553199003604 putative shikimate binding site; other site 553199003605 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 553199003606 dimer interface [polypeptide binding]; other site 553199003607 active site 553199003608 metal binding site [ion binding]; metal-binding site 553199003609 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 553199003610 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 553199003611 putative active site [active] 553199003612 putative metal binding site [ion binding]; other site 553199003613 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 553199003614 elongation factor P; Validated; Region: PRK00529 553199003615 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 553199003616 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 553199003617 RNA binding site [nucleotide binding]; other site 553199003618 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 553199003619 RNA binding site [nucleotide binding]; other site 553199003620 transcription antitermination factor NusB; Region: nusB; TIGR01951 553199003621 putative RNA binding site [nucleotide binding]; other site 553199003622 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 553199003623 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 553199003624 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 553199003625 catalytic site [active] 553199003626 G-X2-G-X-G-K; other site 553199003627 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 553199003628 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 553199003629 Flavoprotein; Region: Flavoprotein; pfam02441 553199003630 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 553199003631 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 553199003632 S-adenosylmethionine synthetase; Validated; Region: PRK05250 553199003633 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 553199003634 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 553199003635 primosome assembly protein PriA; Provisional; Region: PRK14873 553199003636 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 553199003637 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 553199003638 putative active site [active] 553199003639 substrate binding site [chemical binding]; other site 553199003640 putative cosubstrate binding site; other site 553199003641 catalytic site [active] 553199003642 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 553199003643 substrate binding site [chemical binding]; other site 553199003644 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 553199003645 putative RNA binding site [nucleotide binding]; other site 553199003646 16S rRNA methyltransferase B; Provisional; Region: PRK14902 553199003647 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 553199003648 S-adenosylmethionine binding site [chemical binding]; other site 553199003649 CAMP factor (Cfa); Region: CAMP_factor; pfam07373 553199003650 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 553199003651 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 553199003652 substrate binding site [chemical binding]; other site 553199003653 hexamer interface [polypeptide binding]; other site 553199003654 metal binding site [ion binding]; metal-binding site 553199003655 PAC2 family; Region: PAC2; pfam09754 553199003656 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 553199003657 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 553199003658 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 553199003659 motif II; other site 553199003660 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 553199003661 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 553199003662 S-adenosylmethionine binding site [chemical binding]; other site 553199003663 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 553199003664 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 553199003665 Predicted membrane protein [Function unknown]; Region: COG1511 553199003666 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 553199003667 ABC transporter; Region: ABC_tran; pfam00005 553199003668 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 553199003669 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 553199003670 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 553199003671 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 553199003672 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 553199003673 active site 553199003674 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 553199003675 prephenate dehydrogenase; Validated; Region: PRK06545 553199003676 prephenate dehydrogenase; Validated; Region: PRK06545 553199003677 prephenate dehydrogenase; Validated; Region: PRK08507 553199003678 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cd02116 553199003679 cytidylate kinase; Provisional; Region: cmk; PRK00023 553199003680 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 553199003681 CMP-binding site; other site 553199003682 GTP-binding protein Der; Reviewed; Region: PRK03003 553199003683 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 553199003684 G1 box; other site 553199003685 GTP/Mg2+ binding site [chemical binding]; other site 553199003686 Switch I region; other site 553199003687 G2 box; other site 553199003688 Switch II region; other site 553199003689 G3 box; other site 553199003690 G4 box; other site 553199003691 G5 box; other site 553199003692 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 553199003693 G1 box; other site 553199003694 GTP/Mg2+ binding site [chemical binding]; other site 553199003695 Switch I region; other site 553199003696 G2 box; other site 553199003697 G3 box; other site 553199003698 Switch II region; other site 553199003699 G4 box; other site 553199003700 G5 box; other site 553199003701 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 553199003702 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 553199003703 substrate binding site [chemical binding]; other site 553199003704 dimer interface [polypeptide binding]; other site 553199003705 ATP binding site [chemical binding]; other site 553199003706 deoxyribose mutarotase_like; Region: deoxyribose_mutarotase; cd09269 553199003707 active site 553199003708 catalytic residues [active] 553199003709 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 553199003710 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 553199003711 putative substrate translocation pore; other site 553199003712 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 553199003713 intersubunit interface [polypeptide binding]; other site 553199003714 active site 553199003715 catalytic residue [active] 553199003716 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 553199003717 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 553199003718 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 553199003719 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 553199003720 active site 553199003721 motif I; other site 553199003722 motif II; other site 553199003723 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 553199003724 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 553199003725 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 553199003726 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 553199003727 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 553199003728 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 553199003729 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 553199003730 putative DNA binding site [nucleotide binding]; other site 553199003731 putative Zn2+ binding site [ion binding]; other site 553199003732 AsnC family; Region: AsnC_trans_reg; pfam01037 553199003733 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 553199003734 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 553199003735 putative active site [active] 553199003736 catalytic triad [active] 553199003737 putative dimer interface [polypeptide binding]; other site 553199003738 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 553199003739 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 553199003740 Ligand binding site; other site 553199003741 Putative Catalytic site; other site 553199003742 DXD motif; other site 553199003743 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 553199003744 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 553199003745 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 553199003746 putative active site [active] 553199003747 catalytic site [active] 553199003748 putative metal binding site [ion binding]; other site 553199003749 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 553199003750 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 553199003751 non-specific DNA binding site [nucleotide binding]; other site 553199003752 salt bridge; other site 553199003753 sequence-specific DNA binding site [nucleotide binding]; other site 553199003754 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 553199003755 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 553199003756 putative active site [active] 553199003757 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 553199003758 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 553199003759 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 553199003760 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 553199003761 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 553199003762 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 553199003763 dimerization interface [polypeptide binding]; other site 553199003764 putative DNA binding site [nucleotide binding]; other site 553199003765 putative Zn2+ binding site [ion binding]; other site 553199003766 CAMP factor (Cfa); Region: CAMP_factor; pfam07373 553199003767 hypothetical protein; Provisional; Region: PRK09256 553199003768 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 553199003769 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 553199003770 putative substrate translocation pore; other site 553199003771 Transcriptional regulators [Transcription]; Region: MarR; COG1846 553199003772 MarR family; Region: MarR; pfam01047 553199003773 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 553199003774 Fe-S cluster binding site [ion binding]; other site 553199003775 DNA binding site [nucleotide binding] 553199003776 active site 553199003777 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 553199003778 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 553199003779 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 553199003780 gamma subunit interface [polypeptide binding]; other site 553199003781 epsilon subunit interface [polypeptide binding]; other site 553199003782 LBP interface [polypeptide binding]; other site 553199003783 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 553199003784 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 553199003785 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 553199003786 alpha subunit interaction interface [polypeptide binding]; other site 553199003787 Walker A motif; other site 553199003788 ATP binding site [chemical binding]; other site 553199003789 Walker B motif; other site 553199003790 inhibitor binding site; inhibition site 553199003791 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 553199003792 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 553199003793 core domain interface [polypeptide binding]; other site 553199003794 delta subunit interface [polypeptide binding]; other site 553199003795 epsilon subunit interface [polypeptide binding]; other site 553199003796 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 553199003797 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 553199003798 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 553199003799 beta subunit interaction interface [polypeptide binding]; other site 553199003800 Walker A motif; other site 553199003801 ATP binding site [chemical binding]; other site 553199003802 Walker B motif; other site 553199003803 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 553199003804 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210 553199003805 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 553199003806 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 553199003807 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 553199003808 F0F1 ATP synthase subunit C; Validated; Region: PRK07558 553199003809 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 553199003810 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 553199003811 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754 553199003812 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 553199003813 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 553199003814 putative catalytic motif [active] 553199003815 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 553199003816 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 553199003817 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 553199003818 S-adenosylmethionine binding site [chemical binding]; other site 553199003819 peptide chain release factor 1; Validated; Region: prfA; PRK00591 553199003820 PCRF domain; Region: PCRF; pfam03462 553199003821 RF-1 domain; Region: RF-1; pfam00472 553199003822 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 553199003823 transcription termination factor Rho; Provisional; Region: PRK12678 553199003824 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 553199003825 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 553199003826 RNA binding site [nucleotide binding]; other site 553199003827 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 553199003828 Walker A motif; other site 553199003829 ATP binding site [chemical binding]; other site 553199003830 Walker B motif; other site 553199003831 homoserine kinase; Provisional; Region: PRK01212 553199003832 threonine synthase; Reviewed; Region: PRK06721 553199003833 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 553199003834 homodimer interface [polypeptide binding]; other site 553199003835 pyridoxal 5'-phosphate binding site [chemical binding]; other site 553199003836 catalytic residue [active] 553199003837 homoserine dehydrogenase; Provisional; Region: PRK06349 553199003838 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 553199003839 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 553199003840 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 553199003841 diaminopimelate decarboxylase; Region: lysA; TIGR01048 553199003842 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 553199003843 active site 553199003844 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 553199003845 substrate binding site [chemical binding]; other site 553199003846 catalytic residues [active] 553199003847 dimer interface [polypeptide binding]; other site 553199003848 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 553199003849 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 553199003850 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 553199003851 TPP-binding site [chemical binding]; other site 553199003852 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 553199003853 Transcription factor WhiB; Region: Whib; pfam02467 553199003854 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 553199003855 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 553199003856 Histidine kinase; Region: HisKA_2; pfam07568 553199003857 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 553199003858 ATP binding site [chemical binding]; other site 553199003859 Mg2+ binding site [ion binding]; other site 553199003860 G-X-G motif; other site 553199003861 anti-sigma factor, TIGR02949 family; Region: anti_SigH_actin 553199003862 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 553199003863 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 553199003864 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 553199003865 DNA binding residues [nucleotide binding] 553199003866 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 553199003867 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 553199003868 hinge; other site 553199003869 active site 553199003870 Predicted GTPases [General function prediction only]; Region: COG1162 553199003871 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 553199003872 GTPase/Zn-binding domain interface [polypeptide binding]; other site 553199003873 GTP/Mg2+ binding site [chemical binding]; other site 553199003874 G4 box; other site 553199003875 G5 box; other site 553199003876 G1 box; other site 553199003877 Switch I region; other site 553199003878 G2 box; other site 553199003879 G3 box; other site 553199003880 Switch II region; other site 553199003881 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 553199003882 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 553199003883 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 553199003884 active site 553199003885 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 553199003886 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 553199003887 ligand binding site [chemical binding]; other site 553199003888 NAD binding site [chemical binding]; other site 553199003889 tetramer interface [polypeptide binding]; other site 553199003890 catalytic site [active] 553199003891 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 553199003892 L-serine binding site [chemical binding]; other site 553199003893 ACT domain interface; other site 553199003894 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 553199003895 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 553199003896 Walker A/P-loop; other site 553199003897 ATP binding site [chemical binding]; other site 553199003898 Q-loop/lid; other site 553199003899 ABC transporter signature motif; other site 553199003900 Walker B; other site 553199003901 D-loop; other site 553199003902 H-loop/switch region; other site 553199003903 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 553199003904 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 553199003905 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 553199003906 Walker A/P-loop; other site 553199003907 ATP binding site [chemical binding]; other site 553199003908 Q-loop/lid; other site 553199003909 ABC transporter signature motif; other site 553199003910 Walker B; other site 553199003911 D-loop; other site 553199003912 H-loop/switch region; other site 553199003913 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 553199003914 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 553199003915 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 553199003916 dimer interface [polypeptide binding]; other site 553199003917 conserved gate region; other site 553199003918 putative PBP binding loops; other site 553199003919 ABC-ATPase subunit interface; other site 553199003920 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 553199003921 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 553199003922 dimer interface [polypeptide binding]; other site 553199003923 conserved gate region; other site 553199003924 putative PBP binding loops; other site 553199003925 ABC-ATPase subunit interface; other site 553199003926 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 553199003927 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 553199003928 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 553199003929 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 553199003930 Ligand Binding Site [chemical binding]; other site 553199003931 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 553199003932 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 553199003933 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 553199003934 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 553199003935 Protein of unknown function DUF45; Region: DUF45; pfam01863 553199003936 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 553199003937 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 553199003938 Part of AAA domain; Region: AAA_19; pfam13245 553199003939 Family description; Region: UvrD_C_2; pfam13538 553199003940 HRDC domain; Region: HRDC; pfam00570 553199003941 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 553199003942 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 553199003943 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 553199003944 Part of AAA domain; Region: AAA_19; pfam13245 553199003945 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 553199003946 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 553199003947 AAA domain; Region: AAA_30; pfam13604 553199003948 Family description; Region: UvrD_C_2; pfam13538 553199003949 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 553199003950 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 553199003951 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 553199003952 putative NADH binding site [chemical binding]; other site 553199003953 putative active site [active] 553199003954 nudix motif; other site 553199003955 putative metal binding site [ion binding]; other site 553199003956 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 553199003957 Part of AAA domain; Region: AAA_19; pfam13245 553199003958 Family description; Region: UvrD_C_2; pfam13538 553199003959 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 553199003960 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 553199003961 Part of AAA domain; Region: AAA_19; pfam13245 553199003962 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 553199003963 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 553199003964 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 553199003965 active site 553199003966 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 553199003967 tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like; Region: MiaE_2; pfam13794 553199003968 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 553199003969 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 553199003970 ATP binding site [chemical binding]; other site 553199003971 Mg++ binding site [ion binding]; other site 553199003972 motif III; other site 553199003973 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 553199003974 nucleotide binding region [chemical binding]; other site 553199003975 ATP-binding site [chemical binding]; other site 553199003976 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 553199003977 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 553199003978 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 553199003979 active site 553199003980 HIGH motif; other site 553199003981 dimer interface [polypeptide binding]; other site 553199003982 KMSKS motif; other site 553199003983 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 553199003984 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 553199003985 active site 553199003986 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 553199003987 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 553199003988 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 553199003989 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 553199003990 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 553199003991 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 553199003992 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 553199003993 30S subunit binding site; other site 553199003994 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 553199003995 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 553199003996 active site 553199003997 Sporulation and spore germination; Region: Germane; cl11253 553199003998 Lipoprotein LpqB beta-propeller domain; Region: Gmad1; pfam10647 553199003999 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 553199004000 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 553199004001 dimerization interface [polypeptide binding]; other site 553199004002 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 553199004003 dimer interface [polypeptide binding]; other site 553199004004 phosphorylation site [posttranslational modification] 553199004005 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 553199004006 ATP binding site [chemical binding]; other site 553199004007 Mg2+ binding site [ion binding]; other site 553199004008 G-X-G motif; other site 553199004009 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 553199004010 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 553199004011 active site 553199004012 phosphorylation site [posttranslational modification] 553199004013 intermolecular recognition site; other site 553199004014 dimerization interface [polypeptide binding]; other site 553199004015 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 553199004016 DNA binding site [nucleotide binding] 553199004017 hypothetical protein; Validated; Region: PRK00228 553199004018 CAMP factor (Cfa); Region: CAMP_factor; pfam07373 553199004019 ribbon-helix-helix domain containing protein; Region: PHA00617 553199004020 Protein of unknown function (DUF1706); Region: DUF1706; cl01748 553199004021 Protein of unknown function (DUF1706); Region: DUF1706; cl01748 553199004022 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 553199004023 Domain of unknown function (DUF4234); Region: DUF4234; pfam14018 553199004024 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 553199004025 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 553199004026 Tic20-like protein; Region: Tic20; pfam09685 553199004027 argininosuccinate lyase; Provisional; Region: PRK00855 553199004028 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 553199004029 active sites [active] 553199004030 tetramer interface [polypeptide binding]; other site 553199004031 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 553199004032 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 553199004033 inhibitor-cofactor binding pocket; inhibition site 553199004034 pyridoxal 5'-phosphate binding site [chemical binding]; other site 553199004035 catalytic residue [active] 553199004036 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 553199004037 feedback inhibition sensing region; other site 553199004038 homohexameric interface [polypeptide binding]; other site 553199004039 nucleotide binding site [chemical binding]; other site 553199004040 N-acetyl-L-glutamate binding site [chemical binding]; other site 553199004041 DmpA/OAT superfamily; composed of L-aminopeptidase D-amidase/D-esterase (DmpA), ornithine acetyltransferase (OAT) and similar proteins. DmpA is an aminopeptidase that releases N-terminal D and L amino acids from peptide substrates. This group represents...; Region: DmpA_OAT; cl00603 553199004042 DmpA/OAT superfamily; composed of L-aminopeptidase D-amidase/D-esterase (DmpA), ornithine acetyltransferase (OAT) and similar proteins. DmpA is an aminopeptidase that releases N-terminal D and L amino acids from peptide substrates. This group represents...; Region: DmpA_OAT; cl00603 553199004043 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 553199004044 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 553199004045 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 553199004046 SmpB-tmRNA interface; other site 553199004047 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 553199004048 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 553199004049 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 553199004050 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 553199004051 Walker A/P-loop; other site 553199004052 ATP binding site [chemical binding]; other site 553199004053 Q-loop/lid; other site 553199004054 ABC transporter signature motif; other site 553199004055 Walker B; other site 553199004056 D-loop; other site 553199004057 H-loop/switch region; other site 553199004058 peptide chain release factor 2; Validated; Region: prfB; PRK00578 553199004059 This domain is found in peptide chain release factors; Region: PCRF; smart00937 553199004060 RF-1 domain; Region: RF-1; pfam00472 553199004061 Protein of unknown function (DUF805); Region: DUF805; pfam05656 553199004062 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 553199004063 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 553199004064 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 553199004065 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 553199004066 thiamine monophosphate kinase; Provisional; Region: PRK05731 553199004067 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 553199004068 ATP binding site [chemical binding]; other site 553199004069 dimerization interface [polypeptide binding]; other site 553199004070 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 553199004071 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 553199004072 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 553199004073 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 553199004074 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 553199004075 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 553199004076 putative acyl-acceptor binding pocket; other site 553199004077 hypothetical protein; Provisional; Region: PRK14812 553199004078 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 553199004079 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 553199004080 Transcriptional regulator [Transcription]; Region: IclR; COG1414 553199004081 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 553199004082 Bacterial transcriptional regulator; Region: IclR; pfam01614 553199004083 CAAX protease self-immunity; Region: Abi; pfam02517 553199004084 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 553199004085 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 553199004086 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 553199004087 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 553199004088 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 553199004089 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 553199004090 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 553199004091 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 553199004092 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 553199004093 homodimer interface [polypeptide binding]; other site 553199004094 substrate-cofactor binding pocket; other site 553199004095 catalytic residue [active] 553199004096 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 553199004097 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 553199004098 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 553199004099 ketol-acid reductoisomerase; Provisional; Region: PRK05479 553199004100 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 553199004101 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 553199004102 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 553199004103 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 553199004104 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 553199004105 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 553199004106 HIT family signature motif; other site 553199004107 catalytic residue [active] 553199004108 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 553199004109 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 553199004110 substrate binding site [chemical binding]; other site 553199004111 glutamase interaction surface [polypeptide binding]; other site 553199004112 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 553199004113 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 553199004114 ATP binding site [chemical binding]; other site 553199004115 putative Mg++ binding site [ion binding]; other site 553199004116 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 553199004117 nucleotide binding region [chemical binding]; other site 553199004118 ATP-binding site [chemical binding]; other site 553199004119 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 553199004120 Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902 553199004121 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 553199004122 Predicted transcriptional regulator [Transcription]; Region: COG2378 553199004123 WYL domain; Region: WYL; pfam13280 553199004124 Predicted transcriptional regulator [Transcription]; Region: COG2378 553199004125 WYL domain; Region: WYL; pfam13280 553199004126 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 553199004127 active site 553199004128 HIGH motif; other site 553199004129 nucleotide binding site [chemical binding]; other site 553199004130 active site 553199004131 KMSKS motif; other site 553199004132 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 553199004133 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 553199004134 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 553199004135 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 553199004136 RNA binding surface [nucleotide binding]; other site 553199004137 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 553199004138 active site 553199004139 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 553199004140 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 553199004141 P-loop; other site 553199004142 Magnesium ion binding site [ion binding]; other site 553199004143 transport-energizing ATPase, TRC40/GET3/ArsA family; Region: GET3_arsA_TRC40; TIGR00345 553199004144 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 553199004145 Magnesium ion binding site [ion binding]; other site 553199004146 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 553199004147 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 553199004148 active site 553199004149 Int/Topo IB signature motif; other site 553199004150 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 553199004151 dimer interface [polypeptide binding]; other site 553199004152 ADP-ribose binding site [chemical binding]; other site 553199004153 active site 553199004154 nudix motif; other site 553199004155 metal binding site [ion binding]; metal-binding site 553199004156 CTP synthetase; Validated; Region: pyrG; PRK05380 553199004157 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 553199004158 Catalytic site [active] 553199004159 active site 553199004160 UTP binding site [chemical binding]; other site 553199004161 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 553199004162 active site 553199004163 putative oxyanion hole; other site 553199004164 catalytic triad [active] 553199004165 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 553199004166 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 553199004167 Walker A/P-loop; other site 553199004168 ATP binding site [chemical binding]; other site 553199004169 Q-loop/lid; other site 553199004170 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 553199004171 ABC transporter signature motif; other site 553199004172 Walker B; other site 553199004173 D-loop; other site 553199004174 H-loop/switch region; other site 553199004175 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 553199004176 ATP-NAD kinase; Region: NAD_kinase; pfam01513 553199004177 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 553199004178 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 553199004179 RNA binding surface [nucleotide binding]; other site 553199004180 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 553199004181 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 553199004182 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 553199004183 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 553199004184 Walker A/P-loop; other site 553199004185 ATP binding site [chemical binding]; other site 553199004186 Q-loop/lid; other site 553199004187 ABC transporter signature motif; other site 553199004188 Walker B; other site 553199004189 D-loop; other site 553199004190 H-loop/switch region; other site 553199004191 BioY family; Region: BioY; pfam02632 553199004192 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 553199004193 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 553199004194 active site 553199004195 motif I; other site 553199004196 motif II; other site 553199004197 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 553199004198 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 553199004199 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 553199004200 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 553199004201 active site 553199004202 HIGH motif; other site 553199004203 dimer interface [polypeptide binding]; other site 553199004204 KMSKS motif; other site 553199004205 arginine repressor; Provisional; Region: PRK03341 553199004206 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 553199004207 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 553199004208 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 553199004209 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 553199004210 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 553199004211 biotin synthase; Validated; Region: PRK06256 553199004212 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 553199004213 FeS/SAM binding site; other site 553199004214 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 553199004215 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 553199004216 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 553199004217 putative tRNA-binding site [nucleotide binding]; other site 553199004218 B3/4 domain; Region: B3_4; pfam03483 553199004219 tRNA synthetase B5 domain; Region: B5; pfam03484 553199004220 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 553199004221 dimer interface [polypeptide binding]; other site 553199004222 motif 1; other site 553199004223 motif 3; other site 553199004224 motif 2; other site 553199004225 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 553199004226 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 553199004227 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 553199004228 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 553199004229 dimer interface [polypeptide binding]; other site 553199004230 motif 1; other site 553199004231 active site 553199004232 motif 2; other site 553199004233 motif 3; other site 553199004234 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 553199004235 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 553199004236 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 553199004237 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 553199004238 23S rRNA binding site [nucleotide binding]; other site 553199004239 L21 binding site [polypeptide binding]; other site 553199004240 L13 binding site [polypeptide binding]; other site 553199004241 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 553199004242 translation initiation factor IF-3; Region: infC; TIGR00168 553199004243 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 553199004244 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 553199004245 Protein of unknown function (DUF418); Region: DUF418; cl12135 553199004246 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 553199004247 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 553199004248 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 553199004249 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 553199004250 homodimer interface [polypeptide binding]; other site 553199004251 putative metal binding site [ion binding]; other site 553199004252 Nicotinamide mononucleotide transporter [Coenzyme metabolism]; Region: PnuC; COG3201 553199004253 conserved hypothetical protein; Region: TIGR03843 553199004254 conserved hypothetical protein; Region: TIGR03847 553199004255 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 553199004256 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 553199004257 active site 553199004258 catalytic tetrad [active] 553199004259 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 553199004260 dimer interface [polypeptide binding]; other site 553199004261 Citrate synthase; Region: Citrate_synt; pfam00285 553199004262 active site 553199004263 citrylCoA binding site [chemical binding]; other site 553199004264 NADH binding [chemical binding]; other site 553199004265 cationic pore residues; other site 553199004266 oxalacetate/citrate binding site [chemical binding]; other site 553199004267 coenzyme A binding site [chemical binding]; other site 553199004268 catalytic triad [active] 553199004269 hypothetical protein; Provisional; Region: PRK07906 553199004270 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 553199004271 putative metal binding site [ion binding]; other site 553199004272 potential frameshift: common BLAST hit: gi|50842906|ref|YP_056133.1| putative lysophospholipase 553199004273 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 553199004274 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 553199004275 potential frameshift: common BLAST hit: gi|50842906|ref|YP_056133.1| putative lysophospholipase 553199004276 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 553199004277 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 553199004278 CsbD-like; Region: CsbD; pfam05532 553199004279 DNA protecting protein DprA; Region: dprA; TIGR00732 553199004280 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 553199004281 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 553199004282 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 553199004283 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 553199004284 Walker A motif; other site 553199004285 ATP binding site [chemical binding]; other site 553199004286 Walker B motif; other site 553199004287 arginine finger; other site 553199004288 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 553199004289 hypothetical protein; Reviewed; Region: PRK12497 553199004290 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 553199004291 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 553199004292 RNA/DNA hybrid binding site [nucleotide binding]; other site 553199004293 active site 553199004294 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 553199004295 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 553199004296 Catalytic site [active] 553199004297 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 553199004298 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 553199004299 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 553199004300 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 553199004301 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 553199004302 L-aspartate oxidase; Provisional; Region: PRK06175 553199004303 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 553199004304 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 553199004305 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 553199004306 putative Iron-sulfur protein interface [polypeptide binding]; other site 553199004307 proximal heme binding site [chemical binding]; other site 553199004308 distal heme binding site [chemical binding]; other site 553199004309 putative dimer interface [polypeptide binding]; other site 553199004310 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 553199004311 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 553199004312 RimM N-terminal domain; Region: RimM; pfam01782 553199004313 PRC-barrel domain; Region: PRC; pfam05239 553199004314 hypothetical protein; Provisional; Region: PRK02821 553199004315 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 553199004316 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 553199004317 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 553199004318 Amidohydrolase; Region: Amidohydro_4; pfam13147 553199004319 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 553199004320 active site 553199004321 signal recognition particle protein; Provisional; Region: PRK10867 553199004322 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 553199004323 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 553199004324 P loop; other site 553199004325 GTP binding site [chemical binding]; other site 553199004326 Signal peptide binding domain; Region: SRP_SPB; pfam02978 553199004327 Predicted esterase [General function prediction only]; Region: COG0627 553199004328 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 553199004329 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 553199004330 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 553199004331 P loop; other site 553199004332 GTP binding site [chemical binding]; other site 553199004333 Predicted membrane protein [Function unknown]; Region: COG2246 553199004334 GtrA-like protein; Region: GtrA; pfam04138 553199004335 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 553199004336 HicB family; Region: HicB; pfam05534 553199004337 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 553199004338 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 553199004339 DNA binding site [nucleotide binding] 553199004340 H2TH interface [polypeptide binding]; other site 553199004341 putative catalytic residues [active] 553199004342 turnover-facilitating residue; other site 553199004343 intercalation triad [nucleotide binding]; other site 553199004344 8OG recognition residue [nucleotide binding]; other site 553199004345 putative reading head residues; other site 553199004346 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 553199004347 ribonuclease III; Reviewed; Region: rnc; PRK00102 553199004348 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 553199004349 dimerization interface [polypeptide binding]; other site 553199004350 active site 553199004351 metal binding site [ion binding]; metal-binding site 553199004352 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 553199004353 dsRNA binding site [nucleotide binding]; other site 553199004354 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 553199004355 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 553199004356 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 553199004357 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 553199004358 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 553199004359 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 553199004360 dimer interface [polypeptide binding]; other site 553199004361 conserved gate region; other site 553199004362 putative PBP binding loops; other site 553199004363 ABC-ATPase subunit interface; other site 553199004364 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 553199004365 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 553199004366 dimer interface [polypeptide binding]; other site 553199004367 conserved gate region; other site 553199004368 putative PBP binding loops; other site 553199004369 ABC-ATPase subunit interface; other site 553199004370 Transcriptional regulators [Transcription]; Region: PurR; COG1609 553199004371 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 553199004372 DNA binding site [nucleotide binding] 553199004373 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 553199004374 ligand binding site [chemical binding]; other site 553199004375 dimerization interface [polypeptide binding]; other site 553199004376 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 553199004377 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 553199004378 active site 553199004379 catalytic site [active] 553199004380 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; pfam09261 553199004381 Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565 553199004382 putative active site [active] 553199004383 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 553199004384 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 553199004385 conserved gate region; other site 553199004386 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 553199004387 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 553199004388 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 553199004389 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 553199004390 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 553199004391 dimer interface [polypeptide binding]; other site 553199004392 conserved gate region; other site 553199004393 putative PBP binding loops; other site 553199004394 ABC-ATPase subunit interface; other site 553199004395 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 553199004396 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 553199004397 Walker A/P-loop; other site 553199004398 ATP binding site [chemical binding]; other site 553199004399 Q-loop/lid; other site 553199004400 ABC transporter signature motif; other site 553199004401 Walker B; other site 553199004402 D-loop; other site 553199004403 H-loop/switch region; other site 553199004404 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 553199004405 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 553199004406 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 553199004407 Walker A/P-loop; other site 553199004408 ATP binding site [chemical binding]; other site 553199004409 Q-loop/lid; other site 553199004410 ABC transporter signature motif; other site 553199004411 Walker B; other site 553199004412 D-loop; other site 553199004413 H-loop/switch region; other site 553199004414 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 553199004415 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 553199004416 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 553199004417 substrate binding site [chemical binding]; other site 553199004418 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 553199004419 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 553199004420 active site 553199004421 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 553199004422 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 553199004423 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 553199004424 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 553199004425 active site 553199004426 (T/H)XGH motif; other site 553199004427 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 553199004428 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 553199004429 S-adenosylmethionine binding site [chemical binding]; other site 553199004430 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 553199004431 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 553199004432 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 553199004433 ssDNA binding site; other site 553199004434 generic binding surface II; other site 553199004435 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 553199004436 ATP binding site [chemical binding]; other site 553199004437 putative Mg++ binding site [ion binding]; other site 553199004438 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 553199004439 nucleotide binding region [chemical binding]; other site 553199004440 ATP-binding site [chemical binding]; other site 553199004441 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 553199004442 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 553199004443 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 553199004444 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 553199004445 pyruvate dehydrogenase; Provisional; Region: PRK06546 553199004446 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 553199004447 PYR/PP interface [polypeptide binding]; other site 553199004448 dimer interface [polypeptide binding]; other site 553199004449 tetramer interface [polypeptide binding]; other site 553199004450 TPP binding site [chemical binding]; other site 553199004451 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 553199004452 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 553199004453 TPP-binding site [chemical binding]; other site 553199004454 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 553199004455 dihydrodipicolinate reductase; Provisional; Region: PRK00048 553199004456 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 553199004457 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 553199004458 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 553199004459 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 553199004460 oligomer interface [polypeptide binding]; other site 553199004461 RNA binding site [nucleotide binding]; other site 553199004462 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 553199004463 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 553199004464 RNase E interface [polypeptide binding]; other site 553199004465 trimer interface [polypeptide binding]; other site 553199004466 active site 553199004467 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 553199004468 putative nucleic acid binding region [nucleotide binding]; other site 553199004469 G-X-X-G motif; other site 553199004470 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 553199004471 RNA binding site [nucleotide binding]; other site 553199004472 domain interface; other site 553199004473 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 553199004474 16S/18S rRNA binding site [nucleotide binding]; other site 553199004475 S13e-L30e interaction site [polypeptide binding]; other site 553199004476 25S rRNA binding site [nucleotide binding]; other site 553199004477 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 553199004478 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 553199004479 active site 553199004480 Riboflavin kinase; Region: Flavokinase; smart00904 553199004481 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 553199004482 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 553199004483 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 553199004484 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 553199004485 dimer interface [polypeptide binding]; other site 553199004486 conserved gate region; other site 553199004487 ABC-ATPase subunit interface; other site 553199004488 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 553199004489 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 553199004490 Walker A/P-loop; other site 553199004491 ATP binding site [chemical binding]; other site 553199004492 Q-loop/lid; other site 553199004493 ABC transporter signature motif; other site 553199004494 Walker B; other site 553199004495 D-loop; other site 553199004496 H-loop/switch region; other site 553199004497 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 553199004498 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 553199004499 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 553199004500 RNA binding site [nucleotide binding]; other site 553199004501 active site 553199004502 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 553199004503 Cupin domain; Region: Cupin_2; cl17218 553199004504 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 553199004505 HTH domain; Region: HTH_11; pfam08279 553199004506 HTH domain; Region: HTH_11; pfam08279 553199004507 PRD domain; Region: PRD; pfam00874 553199004508 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 553199004509 active site 553199004510 P-loop; other site 553199004511 phosphorylation site [posttranslational modification] 553199004512 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359 553199004513 active site 553199004514 phosphorylation site [posttranslational modification] 553199004515 Glucitol operon activator protein (GutM); Region: GutM; pfam06923 553199004516 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; pfam03608 553199004517 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 553199004518 PTS system, glucitol/sorbitol-specific, IIBC component; Region: EIIBC-GUT; TIGR00825 553199004519 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 553199004520 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829 553199004521 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 553199004522 dimerization domain swap beta strand [polypeptide binding]; other site 553199004523 regulatory protein interface [polypeptide binding]; other site 553199004524 active site 553199004525 regulatory phosphorylation site [posttranslational modification]; other site 553199004526 Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175 553199004527 active site 553199004528 metal binding site [ion binding]; metal-binding site 553199004529 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 553199004530 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 553199004531 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 553199004532 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 553199004533 Walker A/P-loop; other site 553199004534 ATP binding site [chemical binding]; other site 553199004535 Q-loop/lid; other site 553199004536 ABC transporter signature motif; other site 553199004537 Walker B; other site 553199004538 D-loop; other site 553199004539 H-loop/switch region; other site 553199004540 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 553199004541 translation initiation factor IF-2; Region: IF-2; TIGR00487 553199004542 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 553199004543 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 553199004544 G1 box; other site 553199004545 putative GEF interaction site [polypeptide binding]; other site 553199004546 GTP/Mg2+ binding site [chemical binding]; other site 553199004547 Switch I region; other site 553199004548 G2 box; other site 553199004549 G3 box; other site 553199004550 Switch II region; other site 553199004551 G4 box; other site 553199004552 G5 box; other site 553199004553 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 553199004554 Translation-initiation factor 2; Region: IF-2; pfam11987 553199004555 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 553199004556 Protein of unknown function (DUF448); Region: DUF448; pfam04296 553199004557 putative RNA binding cleft [nucleotide binding]; other site 553199004558 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 553199004559 NusA N-terminal domain; Region: NusA_N; pfam08529 553199004560 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 553199004561 RNA binding site [nucleotide binding]; other site 553199004562 homodimer interface [polypeptide binding]; other site 553199004563 NusA-like KH domain; Region: KH_5; pfam13184 553199004564 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 553199004565 G-X-X-G motif; other site 553199004566 ribosome maturation protein RimP; Reviewed; Region: PRK00092 553199004567 Sm and related proteins; Region: Sm_like; cl00259 553199004568 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 553199004569 putative oligomer interface [polypeptide binding]; other site 553199004570 putative RNA binding site [nucleotide binding]; other site 553199004571 hypothetical protein; Provisional; Region: PRK10621 553199004572 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 553199004573 metallophosphoesterase, PPA1498 family; Region: P_acnes_RR; TIGR03767 553199004574 prolyl-tRNA synthetase; Provisional; Region: PRK09194 553199004575 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 553199004576 dimer interface [polypeptide binding]; other site 553199004577 motif 1; other site 553199004578 active site 553199004579 motif 2; other site 553199004580 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 553199004581 putative deacylase active site [active] 553199004582 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 553199004583 active site 553199004584 motif 3; other site 553199004585 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 553199004586 anticodon binding site; other site 553199004587 putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773 553199004588 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 553199004589 putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773 553199004590 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 553199004591 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 553199004592 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 553199004593 anchored repeat ABC transporter, substrate-binding protein; Region: anch_rpt_subst; TIGR03772 553199004594 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 553199004595 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 553199004596 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 553199004597 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 553199004598 anchored repeat-type ABC transporter, ATP-binding subunit; Region: anch_rpt_ABC; TIGR03771 553199004599 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 553199004600 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 553199004601 ABC-ATPase subunit interface; other site 553199004602 dimer interface [polypeptide binding]; other site 553199004603 putative PBP binding regions; other site 553199004604 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 553199004605 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 553199004606 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 553199004607 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 553199004608 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 553199004609 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 553199004610 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 553199004611 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 553199004612 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 553199004613 active site 553199004614 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 553199004615 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 553199004616 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 553199004617 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 553199004618 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 553199004619 Beta-lactamase; Region: Beta-lactamase; pfam00144 553199004620 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 553199004621 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 553199004622 glutamate dehydrogenase; Provisional; Region: PRK09414 553199004623 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 553199004624 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 553199004625 NAD(P) binding site [chemical binding]; other site 553199004626 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 553199004627 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 553199004628 FeS/SAM binding site; other site 553199004629 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 553199004630 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 553199004631 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 553199004632 ribosome recycling factor; Reviewed; Region: frr; PRK00083 553199004633 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 553199004634 hinge region; other site 553199004635 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 553199004636 putative nucleotide binding site [chemical binding]; other site 553199004637 uridine monophosphate binding site [chemical binding]; other site 553199004638 homohexameric interface [polypeptide binding]; other site 553199004639 elongation factor Ts; Provisional; Region: tsf; PRK09377 553199004640 UBA/TS-N domain; Region: UBA; pfam00627 553199004641 Elongation factor TS; Region: EF_TS; pfam00889 553199004642 Elongation factor TS; Region: EF_TS; pfam00889 553199004643 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 553199004644 rRNA interaction site [nucleotide binding]; other site 553199004645 S8 interaction site; other site 553199004646 putative laminin-1 binding site; other site 553199004647 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 553199004648 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 553199004649 active site 553199004650 DNA binding site [nucleotide binding] 553199004651 Int/Topo IB signature motif; other site 553199004652 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 553199004653 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 553199004654 active site 553199004655 catalytic residues [active] 553199004656 metal binding site [ion binding]; metal-binding site 553199004657 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 553199004658 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 553199004659 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 553199004660 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 553199004661 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 553199004662 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 553199004663 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 553199004664 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 553199004665 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 553199004666 Walker A/P-loop; other site 553199004667 ATP binding site [chemical binding]; other site 553199004668 Q-loop/lid; other site 553199004669 ABC transporter signature motif; other site 553199004670 Walker B; other site 553199004671 D-loop; other site 553199004672 H-loop/switch region; other site 553199004673 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 553199004674 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 553199004675 NAD(P) binding site [chemical binding]; other site 553199004676 active site 553199004677 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 553199004678 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 553199004679 NAD(P) binding site [chemical binding]; other site 553199004680 active site 553199004681 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 553199004682 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 553199004683 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 553199004684 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 553199004685 S-adenosylmethionine binding site [chemical binding]; other site 553199004686 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 553199004687 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 553199004688 Walker A/P-loop; other site 553199004689 ATP binding site [chemical binding]; other site 553199004690 Q-loop/lid; other site 553199004691 ABC transporter signature motif; other site 553199004692 Walker B; other site 553199004693 D-loop; other site 553199004694 H-loop/switch region; other site 553199004695 ABC transporter; Region: ABC_tran_2; pfam12848 553199004696 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 553199004697 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 553199004698 Coenzyme A binding pocket [chemical binding]; other site 553199004699 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 553199004700 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 553199004701 phosphate binding site [ion binding]; other site 553199004702 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 553199004703 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 553199004704 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 553199004705 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 553199004706 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 553199004707 trimerization site [polypeptide binding]; other site 553199004708 active site 553199004709 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 553199004710 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 553199004711 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 553199004712 catalytic residue [active] 553199004713 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 553199004714 FeS assembly ATPase SufC; Region: sufC; TIGR01978 553199004715 Walker A/P-loop; other site 553199004716 ATP binding site [chemical binding]; other site 553199004717 Q-loop/lid; other site 553199004718 ABC transporter signature motif; other site 553199004719 Walker B; other site 553199004720 D-loop; other site 553199004721 H-loop/switch region; other site 553199004722 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 553199004723 [2Fe-2S] cluster binding site [ion binding]; other site 553199004724 FeS assembly protein SufD; Region: sufD; TIGR01981 553199004725 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 553199004726 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 553199004727 FeS assembly protein SufB; Region: sufB; TIGR01980 553199004728 Predicted transcriptional regulator [Transcription]; Region: COG2345 553199004729 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 553199004730 dimerization interface [polypeptide binding]; other site 553199004731 putative DNA binding site [nucleotide binding]; other site 553199004732 putative Zn2+ binding site [ion binding]; other site 553199004733 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 553199004734 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 553199004735 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 553199004736 dimer interface [polypeptide binding]; other site 553199004737 conserved gate region; other site 553199004738 putative PBP binding loops; other site 553199004739 ABC-ATPase subunit interface; other site 553199004740 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 553199004741 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 553199004742 dimer interface [polypeptide binding]; other site 553199004743 conserved gate region; other site 553199004744 putative PBP binding loops; other site 553199004745 ABC-ATPase subunit interface; other site 553199004746 Transcriptional regulators [Transcription]; Region: PurR; COG1609 553199004747 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 553199004748 DNA binding site [nucleotide binding] 553199004749 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_10; cd06292 553199004750 putative dimerization interface [polypeptide binding]; other site 553199004751 putative ligand binding site [chemical binding]; other site 553199004752 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 553199004753 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 553199004754 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 553199004755 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 553199004756 Walker A/P-loop; other site 553199004757 ATP binding site [chemical binding]; other site 553199004758 Q-loop/lid; other site 553199004759 ABC transporter signature motif; other site 553199004760 Walker B; other site 553199004761 D-loop; other site 553199004762 H-loop/switch region; other site 553199004763 ABC-2 type transporter; Region: ABC2_membrane; cl17235 553199004764 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 553199004765 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 553199004766 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 553199004767 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 553199004768 catalytic site [active] 553199004769 BNR repeat-like domain; Region: BNR_2; pfam13088 553199004770 Asp-box motif; other site 553199004771 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 553199004772 UbiA prenyltransferase family; Region: UbiA; pfam01040 553199004773 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 553199004774 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 553199004775 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 553199004776 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 553199004777 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 553199004778 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 553199004779 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 553199004780 putative active site [active] 553199004781 DoxX; Region: DoxX; pfam07681 553199004782 Thioredoxin; Region: Thioredoxin_4; cl17273 553199004783 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 553199004784 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208 553199004785 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 553199004786 active site 553199004787 HIGH motif; other site 553199004788 nucleotide binding site [chemical binding]; other site 553199004789 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 553199004790 active site 553199004791 KMSKS motif; other site 553199004792 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 553199004793 tRNA binding surface [nucleotide binding]; other site 553199004794 anticodon binding site; other site 553199004795 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 553199004796 Endo-alpha-N-acetylgalactosaminidase; Region: Glyco_hydro_101; pfam12905 553199004797 Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown]; Region: COG4946 553199004798 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 553199004799 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 553199004800 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 553199004801 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 553199004802 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 553199004803 protein binding site [polypeptide binding]; other site 553199004804 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 553199004805 Domain interface; other site 553199004806 Peptide binding site; other site 553199004807 Active site tetrad [active] 553199004808 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 553199004809 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 553199004810 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 553199004811 Walker A motif; other site 553199004812 ATP binding site [chemical binding]; other site 553199004813 Walker B motif; other site 553199004814 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 553199004815 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 553199004816 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 553199004817 oligomer interface [polypeptide binding]; other site 553199004818 active site residues [active] 553199004819 Clp protease; Region: CLP_protease; pfam00574 553199004820 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 553199004821 oligomer interface [polypeptide binding]; other site 553199004822 active site residues [active] 553199004823 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 553199004824 Domain of unknown function DUF20; Region: UPF0118; pfam01594 553199004825 trigger factor; Provisional; Region: tig; PRK01490 553199004826 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 553199004827 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 553199004828 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 553199004829 potential frameshift: common BLAST hit: gi|50843051|ref|YP_056278.1| putative helicase 553199004830 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 553199004831 ATP binding site [chemical binding]; other site 553199004832 putative Mg++ binding site [ion binding]; other site 553199004833 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 553199004834 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 553199004835 nucleotide binding region [chemical binding]; other site 553199004836 ATP-binding site [chemical binding]; other site 553199004837 potential frameshift: common BLAST hit: gi|19551966|ref|NP_599968.1| type II restriction enzyme, methylase subunits 553199004838 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 553199004839 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 553199004840 ATP binding site [chemical binding]; other site 553199004841 putative Mg++ binding site [ion binding]; other site 553199004842 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 553199004843 ATP-binding site [chemical binding]; other site 553199004844 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 553199004845 Part of AAA domain; Region: AAA_19; pfam13245 553199004846 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 553199004847 Family description; Region: UvrD_C_2; pfam13538 553199004848 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 553199004849 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 553199004850 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 553199004851 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 553199004852 dimer interface [polypeptide binding]; other site 553199004853 putative anticodon binding site; other site 553199004854 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 553199004855 motif 1; other site 553199004856 dimer interface [polypeptide binding]; other site 553199004857 active site 553199004858 motif 2; other site 553199004859 motif 3; other site 553199004860 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 553199004861 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 553199004862 putative DNA binding site [nucleotide binding]; other site 553199004863 catalytic residue [active] 553199004864 putative H2TH interface [polypeptide binding]; other site 553199004865 putative catalytic residues [active] 553199004866 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 553199004867 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 553199004868 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 553199004869 hypothetical protein; Provisional; Region: PRK01346 553199004870 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 553199004871 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 553199004872 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 553199004873 nucleotide binding pocket [chemical binding]; other site 553199004874 K-X-D-G motif; other site 553199004875 catalytic site [active] 553199004876 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 553199004877 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 553199004878 Helix-hairpin-helix motif; Region: HHH; pfam00633 553199004879 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 553199004880 Dimer interface [polypeptide binding]; other site 553199004881 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 553199004882 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 553199004883 Zn binding site [ion binding]; other site 553199004884 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 553199004885 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 553199004886 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 553199004887 potential frameshift: common BLAST hit: gi|50843098|ref|YP_056325.1| alpha-glucosidase/amylase family protein 553199004888 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 553199004889 active site 553199004890 catalytic site [active] 553199004891 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 553199004892 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 553199004893 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 553199004894 active site 553199004895 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 553199004896 active site 553199004897 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 553199004898 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 553199004899 acyl-activating enzyme (AAE) consensus motif; other site 553199004900 putative AMP binding site [chemical binding]; other site 553199004901 putative active site [active] 553199004902 putative CoA binding site [chemical binding]; other site 553199004903 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 553199004904 MarR family; Region: MarR_2; pfam12802 553199004905 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 553199004906 FAD binding domain; Region: FAD_binding_4; pfam01565 553199004907 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 553199004908 Predicted transcriptional regulators [Transcription]; Region: COG1695 553199004909 Transcriptional regulator PadR-like family; Region: PadR; cl17335 553199004910 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 553199004911 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 553199004912 Walker A/P-loop; other site 553199004913 ATP binding site [chemical binding]; other site 553199004914 Q-loop/lid; other site 553199004915 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 553199004916 ABC transporter; Region: ABC_tran_2; pfam12848 553199004917 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 553199004918 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 553199004919 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 553199004920 dimer interface [polypeptide binding]; other site 553199004921 ssDNA binding site [nucleotide binding]; other site 553199004922 tetramer (dimer of dimers) interface [polypeptide binding]; other site 553199004923 YfjP GTPase; Region: YfjP; cd11383 553199004924 G1 box; other site 553199004925 GTP/Mg2+ binding site [chemical binding]; other site 553199004926 Switch I region; other site 553199004927 G2 box; other site 553199004928 Switch II region; other site 553199004929 G3 box; other site 553199004930 G4 box; other site 553199004931 G5 box; other site 553199004932 Dynamin family; Region: Dynamin_N; pfam00350 553199004933 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 553199004934 G1 box; other site 553199004935 GTP/Mg2+ binding site [chemical binding]; other site 553199004936 G2 box; other site 553199004937 Switch I region; other site 553199004938 Protease prsW family; Region: PrsW-protease; pfam13367 553199004939 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 553199004940 putative substrate translocation pore; other site 553199004941 Major Facilitator Superfamily; Region: MFS_1; pfam07690 553199004942 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 553199004943 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 553199004944 catalytic site [active] 553199004945 putative active site [active] 553199004946 putative substrate binding site [chemical binding]; other site 553199004947 dimer interface [polypeptide binding]; other site 553199004948 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 553199004949 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 553199004950 Catalytic domain of Protein Kinases; Region: PKc; cd00180 553199004951 active site 553199004952 ATP binding site [chemical binding]; other site 553199004953 substrate binding site [chemical binding]; other site 553199004954 activation loop (A-loop); other site 553199004955 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 553199004956 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 553199004957 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 553199004958 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 553199004959 active site 553199004960 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 553199004961 generic binding surface I; other site 553199004962 generic binding surface II; other site 553199004963 DNA Polymerase Y-family; Region: PolY_like; cd03468 553199004964 active site 553199004965 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 553199004966 DNA binding site [nucleotide binding] 553199004967 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 553199004968 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 553199004969 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 553199004970 catalytic triad [active] 553199004971 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 553199004972 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 553199004973 potential frameshift: common BLAST hit: gi|50843121|ref|YP_056348.1| binding-protein-dependent transport system inner membrane component 553199004974 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 553199004975 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 553199004976 ABC-ATPase subunit interface; other site 553199004977 putative PBP binding loops; other site 553199004978 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 553199004979 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 553199004980 dimer interface [polypeptide binding]; other site 553199004981 conserved gate region; other site 553199004982 putative PBP binding loops; other site 553199004983 ABC-ATPase subunit interface; other site 553199004984 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 553199004985 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 553199004986 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 553199004987 catalytic triad [active] 553199004988 CH-type (Chalaropsis-type) lysozymes represent one of four functionally-defined classes of peptidoglycan hydrolases (also referred to as endo-N-acetylmuramidases) that cleave bacterial cell wall peptidoglycans. CH-type lysozymes exhibit both lysozyme; Region: GH25_CH-type; cd06412 553199004989 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 553199004990 active site 553199004991 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 553199004992 active site 553199004993 catalytic triad [active] 553199004994 oxyanion hole [active] 553199004995 Thrombospondin type 3 repeat; Region: TSP_3; pfam02412 553199004996 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 553199004997 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 553199004998 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 553199004999 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 553199005000 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 553199005001 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 553199005002 putative active site [active] 553199005003 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 553199005004 DNA polymerase IV; Provisional; Region: PRK03348 553199005005 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 553199005006 active site 553199005007 DNA binding site [nucleotide binding] 553199005008 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 553199005009 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 553199005010 folate binding site [chemical binding]; other site 553199005011 NADP+ binding site [chemical binding]; other site 553199005012 thymidylate synthase; Reviewed; Region: thyA; PRK01827 553199005013 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 553199005014 dimerization interface [polypeptide binding]; other site 553199005015 active site 553199005016 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 553199005017 active site 553199005018 dimerization interface [polypeptide binding]; other site 553199005019 ribonuclease PH; Reviewed; Region: rph; PRK00173 553199005020 Ribonuclease PH; Region: RNase_PH_bact; cd11362 553199005021 hexamer interface [polypeptide binding]; other site 553199005022 active site 553199005023 glutamate racemase; Provisional; Region: PRK00865 553199005024 FeoA domain; Region: FeoA; pfam04023 553199005025 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 553199005026 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 553199005027 G1 box; other site 553199005028 GTP/Mg2+ binding site [chemical binding]; other site 553199005029 Switch I region; other site 553199005030 G2 box; other site 553199005031 G3 box; other site 553199005032 Switch II region; other site 553199005033 G4 box; other site 553199005034 G5 box; other site 553199005035 Nucleoside recognition; Region: Gate; pfam07670 553199005036 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 553199005037 Nucleoside recognition; Region: Gate; pfam07670 553199005038 NifU-like domain; Region: NifU; cl00484 553199005039 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 553199005040 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 553199005041 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 553199005042 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 553199005043 active site 553199005044 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 553199005045 IHF dimer interface [polypeptide binding]; other site 553199005046 IHF - DNA interface [nucleotide binding]; other site 553199005047 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 553199005048 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 553199005049 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 553199005050 RDD family; Region: RDD; pfam06271 553199005051 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 553199005052 Dehydroquinase class II; Region: DHquinase_II; pfam01220 553199005053 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 553199005054 trimer interface [polypeptide binding]; other site 553199005055 active site 553199005056 dimer interface [polypeptide binding]; other site 553199005057 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 553199005058 Cation efflux family; Region: Cation_efflux; pfam01545 553199005059 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 553199005060 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 553199005061 Trm112p-like protein; Region: Trm112p; cl01066 553199005062 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 553199005063 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 553199005064 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 553199005065 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 553199005066 active site 553199005067 Transcription factor WhiB; Region: Whib; pfam02467 553199005068 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 553199005069 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 553199005070 Substrate binding site; other site 553199005071 TIGR03089 family protein; Region: TIGR03089 553199005072 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 553199005073 ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525 553199005074 Ligand binding site; other site 553199005075 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 553199005076 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 553199005077 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 553199005078 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 553199005079 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 553199005080 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 553199005081 AIR carboxylase; Region: AIRC; pfam00731 553199005082 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 553199005083 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 553199005084 NAD binding site [chemical binding]; other site 553199005085 ATP-grasp domain; Region: ATP-grasp; pfam02222 553199005086 Bacterial PH domain; Region: DUF304; cl01348 553199005087 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 553199005088 active site pocket [active] 553199005089 oxyanion hole [active] 553199005090 catalytic triad [active] 553199005091 active site nucleophile [active] 553199005092 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 553199005093 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 553199005094 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 553199005095 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 553199005096 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 553199005097 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 553199005098 Maf-like protein; Region: Maf; pfam02545 553199005099 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 553199005100 active site 553199005101 dimer interface [polypeptide binding]; other site 553199005102 short chain dehydrogenase; Provisional; Region: PRK08219 553199005103 classical (c) SDRs; Region: SDR_c; cd05233 553199005104 NAD(P) binding site [chemical binding]; other site 553199005105 active site 553199005106 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 553199005107 dimer interface [polypeptide binding]; other site 553199005108 substrate binding site [chemical binding]; other site 553199005109 ATP binding site [chemical binding]; other site 553199005110 potential frameshift: common BLAST hit: gi|288961215|ref|YP_003451554.1| dicarboxylate carrier MatC domain protein 553199005111 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 553199005112 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 553199005113 Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158 553199005114 TQXA domain; Region: TQXA_dom; TIGR03934 553199005115 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 553199005116 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 553199005117 oligomer interface [polypeptide binding]; other site 553199005118 metal binding site [ion binding]; metal-binding site 553199005119 metal binding site [ion binding]; metal-binding site 553199005120 putative Cl binding site [ion binding]; other site 553199005121 aspartate ring; other site 553199005122 basic sphincter; other site 553199005123 hydrophobic gate; other site 553199005124 periplasmic entrance; other site 553199005125 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 553199005126 nudix motif; other site 553199005127 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 553199005128 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 553199005129 ATP-grasp domain; Region: ATP-grasp_4; cl17255 553199005130 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 553199005131 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 553199005132 carboxyltransferase (CT) interaction site; other site 553199005133 biotinylation site [posttranslational modification]; other site 553199005134 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 553199005135 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 553199005136 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 553199005137 purine nucleoside phosphorylase; Provisional; Region: PRK08202 553199005138 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 553199005139 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 553199005140 active site 553199005141 substrate binding site [chemical binding]; other site 553199005142 metal binding site [ion binding]; metal-binding site 553199005143 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 553199005144 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 553199005145 acyl-activating enzyme (AAE) consensus motif; other site 553199005146 AMP binding site [chemical binding]; other site 553199005147 active site 553199005148 CoA binding site [chemical binding]; other site 553199005149 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 553199005150 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 553199005151 putative substrate translocation pore; other site 553199005152 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 553199005153 active site 553199005154 catalytic site [active] 553199005155 substrate binding site [chemical binding]; other site 553199005156 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 553199005157 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 553199005158 active site 553199005159 HIGH motif; other site 553199005160 KMSKS motif; other site 553199005161 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 553199005162 tRNA binding surface [nucleotide binding]; other site 553199005163 anticodon binding site; other site 553199005164 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 553199005165 RNA/DNA hybrid binding site [nucleotide binding]; other site 553199005166 active site 553199005167 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 553199005168 active site 553199005169 catalytic motif [active] 553199005170 Zn binding site [ion binding]; other site 553199005171 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 553199005172 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 553199005173 TM-ABC transporter signature motif; other site 553199005174 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 553199005175 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 553199005176 TM-ABC transporter signature motif; other site 553199005177 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 553199005178 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 553199005179 Walker A/P-loop; other site 553199005180 ATP binding site [chemical binding]; other site 553199005181 Q-loop/lid; other site 553199005182 ABC transporter signature motif; other site 553199005183 Walker B; other site 553199005184 D-loop; other site 553199005185 H-loop/switch region; other site 553199005186 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 553199005187 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 553199005188 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 553199005189 ligand binding site [chemical binding]; other site 553199005190 Phosphotransferase enzyme family; Region: APH; pfam01636 553199005191 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 553199005192 Domain of unknown function DUF21; Region: DUF21; pfam01595 553199005193 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 553199005194 Transporter associated domain; Region: CorC_HlyC; smart01091 553199005195 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 553199005196 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 553199005197 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 553199005198 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 553199005199 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 553199005200 active site 553199005201 substrate binding site [chemical binding]; other site 553199005202 cosubstrate binding site; other site 553199005203 catalytic site [active] 553199005204 malate dehydrogenase; Provisional; Region: PRK05442 553199005205 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 553199005206 NAD(P) binding site [chemical binding]; other site 553199005207 dimer interface [polypeptide binding]; other site 553199005208 malate binding site [chemical binding]; other site 553199005209 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 553199005210 putative catalytic cysteine [active] 553199005211 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 553199005212 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 553199005213 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 553199005214 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 553199005215 homodimer interface [polypeptide binding]; other site 553199005216 NADP binding site [chemical binding]; other site 553199005217 substrate binding site [chemical binding]; other site 553199005218 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 553199005219 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 553199005220 catalytic residue [active] 553199005221 Phosphoesterase family; Region: Phosphoesterase; pfam04185 553199005222 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 553199005223 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 553199005224 purine monophosphate binding site [chemical binding]; other site 553199005225 dimer interface [polypeptide binding]; other site 553199005226 putative catalytic residues [active] 553199005227 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 553199005228 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 553199005229 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 553199005230 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 553199005231 active site 553199005232 cosubstrate binding site; other site 553199005233 substrate binding site [chemical binding]; other site 553199005234 catalytic site [active] 553199005235 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 553199005236 homopentamer interface [polypeptide binding]; other site 553199005237 active site 553199005238 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 553199005239 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 553199005240 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 553199005241 dimerization interface [polypeptide binding]; other site 553199005242 active site 553199005243 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 553199005244 Lumazine binding domain; Region: Lum_binding; pfam00677 553199005245 Lumazine binding domain; Region: Lum_binding; pfam00677 553199005246 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 553199005247 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 553199005248 catalytic motif [active] 553199005249 Zn binding site [ion binding]; other site 553199005250 RibD C-terminal domain; Region: RibD_C; cl17279 553199005251 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 553199005252 CoA binding domain; Region: CoA_binding; smart00881 553199005253 CoA-ligase; Region: Ligase_CoA; pfam00549 553199005254 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 553199005255 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 553199005256 CoA-ligase; Region: Ligase_CoA; pfam00549 553199005257 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 553199005258 Part of AAA domain; Region: AAA_19; pfam13245 553199005259 Family description; Region: UvrD_C_2; pfam13538 553199005260 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 553199005261 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 553199005262 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 553199005263 Walker A/P-loop; other site 553199005264 ATP binding site [chemical binding]; other site 553199005265 Q-loop/lid; other site 553199005266 ABC transporter signature motif; other site 553199005267 Walker B; other site 553199005268 D-loop; other site 553199005269 H-loop/switch region; other site 553199005270 NIL domain; Region: NIL; pfam09383 553199005271 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 553199005272 ABC-ATPase subunit interface; other site 553199005273 potential frameshift: common BLAST hit: gi|50843221|ref|YP_056448.1| cardiolipin synthetase 553199005274 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 553199005275 PLD-like domain; Region: PLDc_2; pfam13091 553199005276 putative active site [active] 553199005277 catalytic site [active] 553199005278 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 553199005279 PLD-like domain; Region: PLDc_2; pfam13091 553199005280 putative active site [active] 553199005281 catalytic site [active] 553199005282 PspC domain; Region: PspC; pfam04024 553199005283 GMP synthase; Reviewed; Region: guaA; PRK00074 553199005284 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 553199005285 AMP/PPi binding site [chemical binding]; other site 553199005286 candidate oxyanion hole; other site 553199005287 catalytic triad [active] 553199005288 potential glutamine specificity residues [chemical binding]; other site 553199005289 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 553199005290 ATP Binding subdomain [chemical binding]; other site 553199005291 Ligand Binding sites [chemical binding]; other site 553199005292 Dimerization subdomain; other site 553199005293 serine O-acetyltransferase; Region: cysE; TIGR01172 553199005294 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 553199005295 trimer interface [polypeptide binding]; other site 553199005296 active site 553199005297 substrate binding site [chemical binding]; other site 553199005298 CoA binding site [chemical binding]; other site 553199005299 chorismate mutase; Provisional; Region: PRK09239 553199005300 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 553199005301 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 553199005302 phosphate binding site [ion binding]; other site 553199005303 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 553199005304 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 553199005305 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 553199005306 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 553199005307 active site 553199005308 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 553199005309 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 553199005310 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 553199005311 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 553199005312 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 553199005313 ring oligomerisation interface [polypeptide binding]; other site 553199005314 ATP/Mg binding site [chemical binding]; other site 553199005315 stacking interactions; other site 553199005316 hinge regions; other site 553199005317 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 553199005318 oligomerisation interface [polypeptide binding]; other site 553199005319 mobile loop; other site 553199005320 roof hairpin; other site 553199005321 Methyltransferase domain; Region: Methyltransf_26; pfam13659 553199005322 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 553199005323 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 553199005324 Walker A/P-loop; other site 553199005325 ATP binding site [chemical binding]; other site 553199005326 Q-loop/lid; other site 553199005327 ABC transporter signature motif; other site 553199005328 Walker B; other site 553199005329 D-loop; other site 553199005330 H-loop/switch region; other site 553199005331 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 553199005332 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 553199005333 ABC-ATPase subunit interface; other site 553199005334 dimer interface [polypeptide binding]; other site 553199005335 putative PBP binding regions; other site 553199005336 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 553199005337 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 553199005338 intersubunit interface [polypeptide binding]; other site 553199005339 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 553199005340 putative active site [active] 553199005341 nucleotide binding site [chemical binding]; other site 553199005342 nudix motif; other site 553199005343 putative metal binding site [ion binding]; other site 553199005344 UGMP family protein; Validated; Region: PRK09604 553199005345 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 553199005346 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 553199005347 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 553199005348 Coenzyme A binding pocket [chemical binding]; other site 553199005349 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 553199005350 Glycoprotease family; Region: Peptidase_M22; pfam00814 553199005351 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 553199005352 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 553199005353 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 553199005354 DEAD-like helicases superfamily; Region: DEXDc; smart00487 553199005355 ATP binding site [chemical binding]; other site 553199005356 Mg++ binding site [ion binding]; other site 553199005357 motif III; other site 553199005358 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 553199005359 nucleotide binding region [chemical binding]; other site 553199005360 ATP-binding site [chemical binding]; other site 553199005361 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 553199005362 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 553199005363 Walker A/P-loop; other site 553199005364 ATP binding site [chemical binding]; other site 553199005365 Q-loop/lid; other site 553199005366 ABC transporter signature motif; other site 553199005367 Walker B; other site 553199005368 D-loop; other site 553199005369 H-loop/switch region; other site 553199005370 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 553199005371 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 553199005372 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 553199005373 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 553199005374 putative substrate binding site [chemical binding]; other site 553199005375 putative ATP binding site [chemical binding]; other site 553199005376 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 553199005377 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 553199005378 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 553199005379 glutaminase active site [active] 553199005380 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 553199005381 dimer interface [polypeptide binding]; other site 553199005382 active site 553199005383 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 553199005384 dimer interface [polypeptide binding]; other site 553199005385 active site 553199005386 Lipase (class 2); Region: Lipase_2; pfam01674 553199005387 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 553199005388 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 553199005389 Lipase (class 2); Region: Lipase_2; pfam01674 553199005390 pantothenate kinase; Provisional; Region: PRK05439 553199005391 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 553199005392 ATP-binding site [chemical binding]; other site 553199005393 CoA-binding site [chemical binding]; other site 553199005394 Mg2+-binding site [ion binding]; other site 553199005395 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 553199005396 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 553199005397 active site 553199005398 substrate binding site [chemical binding]; other site 553199005399 metal binding site [ion binding]; metal-binding site 553199005400 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 553199005401 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 553199005402 23S rRNA interface [nucleotide binding]; other site 553199005403 L3 interface [polypeptide binding]; other site 553199005404 Endo-beta-N-acetylglucosaminidase D [Carbohydrate transport and metabolism]; Region: COG4724 553199005405 Glycosyl hydrolase family 85; Region: Glyco_hydro_85; pfam03644 553199005406 active site 553199005407 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 553199005408 S-adenosylmethionine binding site [chemical binding]; other site 553199005409 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 553199005410 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 553199005411 dimerization interface 3.5A [polypeptide binding]; other site 553199005412 active site 553199005413 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 553199005414 S-adenosylmethionine binding site [chemical binding]; other site 553199005415 Cobalt transport protein; Region: CbiQ; cl00463 553199005416 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 553199005417 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 553199005418 Walker A/P-loop; other site 553199005419 ATP binding site [chemical binding]; other site 553199005420 Q-loop/lid; other site 553199005421 ABC transporter signature motif; other site 553199005422 Walker B; other site 553199005423 D-loop; other site 553199005424 H-loop/switch region; other site 553199005425 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 553199005426 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 553199005427 Walker A/P-loop; other site 553199005428 ATP binding site [chemical binding]; other site 553199005429 Q-loop/lid; other site 553199005430 ABC transporter signature motif; other site 553199005431 Walker B; other site 553199005432 D-loop; other site 553199005433 H-loop/switch region; other site 553199005434 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 553199005435 classical (c) SDRs; Region: SDR_c; cd05233 553199005436 NAD(P) binding site [chemical binding]; other site 553199005437 active site 553199005438 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 553199005439 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 553199005440 Walker A/P-loop; other site 553199005441 ATP binding site [chemical binding]; other site 553199005442 Q-loop/lid; other site 553199005443 ABC transporter signature motif; other site 553199005444 Walker B; other site 553199005445 D-loop; other site 553199005446 H-loop/switch region; other site 553199005447 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 553199005448 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 553199005449 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 553199005450 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 553199005451 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 553199005452 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 553199005453 Major Facilitator Superfamily; Region: MFS_1; pfam07690 553199005454 putative substrate translocation pore; other site 553199005455 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 553199005456 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 553199005457 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 553199005458 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 553199005459 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 553199005460 alphaNTD homodimer interface [polypeptide binding]; other site 553199005461 alphaNTD - beta interaction site [polypeptide binding]; other site 553199005462 alphaNTD - beta' interaction site [polypeptide binding]; other site 553199005463 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 553199005464 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 553199005465 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 553199005466 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 553199005467 RNA binding surface [nucleotide binding]; other site 553199005468 30S ribosomal protein S11; Validated; Region: PRK05309 553199005469 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 553199005470 30S ribosomal protein S13; Region: bact_S13; TIGR03631 553199005471 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 553199005472 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 553199005473 rRNA binding site [nucleotide binding]; other site 553199005474 predicted 30S ribosome binding site; other site 553199005475 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 553199005476 active site 553199005477 adenylate kinase; Reviewed; Region: adk; PRK00279 553199005478 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 553199005479 AMP-binding site [chemical binding]; other site 553199005480 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 553199005481 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 553199005482 SecY translocase; Region: SecY; pfam00344 553199005483 Major Facilitator Superfamily; Region: MFS_1; pfam07690 553199005484 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 553199005485 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 553199005486 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 553199005487 putative active site [active] 553199005488 catalytic site [active] 553199005489 putative metal binding site [ion binding]; other site 553199005490 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 553199005491 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 553199005492 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 553199005493 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 553199005494 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 553199005495 23S rRNA binding site [nucleotide binding]; other site 553199005496 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 553199005497 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 553199005498 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 553199005499 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 553199005500 23S rRNA interface [nucleotide binding]; other site 553199005501 5S rRNA interface [nucleotide binding]; other site 553199005502 L27 interface [polypeptide binding]; other site 553199005503 L5 interface [polypeptide binding]; other site 553199005504 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 553199005505 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 553199005506 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 553199005507 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 553199005508 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 553199005509 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 553199005510 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 553199005511 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 553199005512 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 553199005513 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 553199005514 RNA binding site [nucleotide binding]; other site 553199005515 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 553199005516 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 553199005517 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 553199005518 23S rRNA interface [nucleotide binding]; other site 553199005519 putative translocon interaction site; other site 553199005520 signal recognition particle (SRP54) interaction site; other site 553199005521 L23 interface [polypeptide binding]; other site 553199005522 trigger factor interaction site; other site 553199005523 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 553199005524 23S rRNA interface [nucleotide binding]; other site 553199005525 5S rRNA interface [nucleotide binding]; other site 553199005526 putative antibiotic binding site [chemical binding]; other site 553199005527 L25 interface [polypeptide binding]; other site 553199005528 L27 interface [polypeptide binding]; other site 553199005529 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 553199005530 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 553199005531 G-X-X-G motif; other site 553199005532 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 553199005533 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 553199005534 putative translocon binding site; other site 553199005535 protein-rRNA interface [nucleotide binding]; other site 553199005536 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 553199005537 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 553199005538 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 553199005539 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 553199005540 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 553199005541 50S ribosomal protein L4; Provisional; Region: rplD; PRK14547 553199005542 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 553199005543 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 553199005544 6-carboxyhexanoate--CoA ligase; Region: BioW; pfam03744 553199005545 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 553199005546 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 553199005547 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 553199005548 catalytic residue [active] 553199005549 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 553199005550 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 553199005551 HIGH motif; other site 553199005552 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 553199005553 active site 553199005554 KMSKS motif; other site 553199005555 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 553199005556 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 553199005557 active site 553199005558 HIGH motif; other site 553199005559 nucleotide binding site [chemical binding]; other site 553199005560 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 553199005561 active site 553199005562 KMSKS motif; other site 553199005563 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 553199005564 2',3'-cyclic-nucleotide 2'-phosphodiesterase; Region: CycNucDiestase; TIGR01390 553199005565 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 553199005566 active site 553199005567 metal binding site [ion binding]; metal-binding site 553199005568 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 553199005569 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 553199005570 elongation factor Tu; Reviewed; Region: PRK00049 553199005571 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 553199005572 G1 box; other site 553199005573 GEF interaction site [polypeptide binding]; other site 553199005574 GTP/Mg2+ binding site [chemical binding]; other site 553199005575 Switch I region; other site 553199005576 G2 box; other site 553199005577 G3 box; other site 553199005578 Switch II region; other site 553199005579 G4 box; other site 553199005580 G5 box; other site 553199005581 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 553199005582 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 553199005583 Antibiotic Binding Site [chemical binding]; other site 553199005584 elongation factor G; Reviewed; Region: PRK00007 553199005585 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 553199005586 G1 box; other site 553199005587 putative GEF interaction site [polypeptide binding]; other site 553199005588 GTP/Mg2+ binding site [chemical binding]; other site 553199005589 Switch I region; other site 553199005590 G2 box; other site 553199005591 G3 box; other site 553199005592 Switch II region; other site 553199005593 G4 box; other site 553199005594 G5 box; other site 553199005595 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 553199005596 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 553199005597 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 553199005598 30S ribosomal protein S7; Validated; Region: PRK05302 553199005599 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 553199005600 S17 interaction site [polypeptide binding]; other site 553199005601 S8 interaction site; other site 553199005602 16S rRNA interaction site [nucleotide binding]; other site 553199005603 streptomycin interaction site [chemical binding]; other site 553199005604 23S rRNA interaction site [nucleotide binding]; other site 553199005605 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 553199005606 Filamin/ABP280 repeat; Region: Filamin; pfam00630 553199005607 putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773 553199005608 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 553199005609 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 553199005610 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 553199005611 DNA-directed RNA polymerase, beta' subunit, predominant form; Region: rpoC_TIGR; TIGR02386 553199005612 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 553199005613 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 553199005614 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 553199005615 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 553199005616 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 553199005617 G-loop; other site 553199005618 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 553199005619 DNA binding site [nucleotide binding] 553199005620 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 553199005621 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 553199005622 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 553199005623 RPB12 interaction site [polypeptide binding]; other site 553199005624 RPB1 interaction site [polypeptide binding]; other site 553199005625 RPB10 interaction site [polypeptide binding]; other site 553199005626 RPB11 interaction site [polypeptide binding]; other site 553199005627 RPB3 interaction site [polypeptide binding]; other site 553199005628 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 553199005629 core dimer interface [polypeptide binding]; other site 553199005630 peripheral dimer interface [polypeptide binding]; other site 553199005631 L10 interface [polypeptide binding]; other site 553199005632 L11 interface [polypeptide binding]; other site 553199005633 putative EF-Tu interaction site [polypeptide binding]; other site 553199005634 putative EF-G interaction site [polypeptide binding]; other site 553199005635 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 553199005636 23S rRNA interface [nucleotide binding]; other site 553199005637 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 553199005638 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 553199005639 mRNA/rRNA interface [nucleotide binding]; other site 553199005640 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 553199005641 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 553199005642 23S rRNA interface [nucleotide binding]; other site 553199005643 putative thiostrepton binding site; other site 553199005644 L7/L12 interface [polypeptide binding]; other site 553199005645 L25 interface [polypeptide binding]; other site 553199005646 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 553199005647 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 553199005648 putative homodimer interface [polypeptide binding]; other site 553199005649 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 553199005650 heterodimer interface [polypeptide binding]; other site 553199005651 homodimer interface [polypeptide binding]; other site 553199005652 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 553199005653 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 553199005654 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 553199005655 pyridoxal 5'-phosphate binding site [chemical binding]; other site 553199005656 homodimer interface [polypeptide binding]; other site 553199005657 catalytic residue [active] 553199005658 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 553199005659 FAD binding domain; Region: FAD_binding_4; pfam01565 553199005660 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 553199005661 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 553199005662 active site 553199005663 catalytic site [active] 553199005664 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 553199005665 active site 553199005666 catalytic site [active] 553199005667 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 553199005668 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 553199005669 putative active site [active] 553199005670 putative catalytic site [active] 553199005671 putative DNA binding site [nucleotide binding]; other site 553199005672 putative phosphate binding site [ion binding]; other site 553199005673 metal binding site A [ion binding]; metal-binding site 553199005674 putative AP binding site [nucleotide binding]; other site 553199005675 putative metal binding site B [ion binding]; other site 553199005676 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 553199005677 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 553199005678 substrate binding site [chemical binding]; other site 553199005679 oxyanion hole (OAH) forming residues; other site 553199005680 trimer interface [polypeptide binding]; other site 553199005681 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 553199005682 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 553199005683 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 553199005684 4Fe-4S binding domain; Region: Fer4; cl02805 553199005685 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329 553199005686 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194 553199005687 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 553199005688 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 553199005689 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 553199005690 dimer interface [polypeptide binding]; other site 553199005691 PYR/PP interface [polypeptide binding]; other site 553199005692 TPP binding site [chemical binding]; other site 553199005693 substrate binding site [chemical binding]; other site 553199005694 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 553199005695 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 553199005696 TPP-binding site [chemical binding]; other site 553199005697 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 553199005698 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 553199005699 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 553199005700 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 553199005701 active site 553199005702 catalytic triad [active] 553199005703 oxyanion hole [active] 553199005704 Thrombospondin type 3 repeat; Region: TSP_3; pfam02412 553199005705 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 553199005706 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 553199005707 active site 553199005708 Zn binding site [ion binding]; other site 553199005709 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136 553199005710 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 553199005711 Walker A/P-loop; other site 553199005712 ATP binding site [chemical binding]; other site 553199005713 Q-loop/lid; other site 553199005714 ABC transporter signature motif; other site 553199005715 Walker B; other site 553199005716 D-loop; other site 553199005717 H-loop/switch region; other site 553199005718 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 553199005719 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 553199005720 Walker A/P-loop; other site 553199005721 ATP binding site [chemical binding]; other site 553199005722 Q-loop/lid; other site 553199005723 ABC transporter signature motif; other site 553199005724 Walker B; other site 553199005725 D-loop; other site 553199005726 H-loop/switch region; other site 553199005727 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 553199005728 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 553199005729 active site 553199005730 SAM binding site [chemical binding]; other site 553199005731 homodimer interface [polypeptide binding]; other site 553199005732 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 553199005733 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 553199005734 substrate binding pocket [chemical binding]; other site 553199005735 chain length determination region; other site 553199005736 substrate-Mg2+ binding site; other site 553199005737 catalytic residues [active] 553199005738 aspartate-rich region 1; other site 553199005739 active site lid residues [active] 553199005740 aspartate-rich region 2; other site 553199005741 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 553199005742 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 553199005743 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 553199005744 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 553199005745 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 553199005746 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 553199005747 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 553199005748 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 553199005749 NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839 553199005750 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 553199005751 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 553199005752 4Fe-4S binding domain; Region: Fer4; pfam00037 553199005753 4Fe-4S binding domain; Region: Fer4; pfam00037 553199005754 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 553199005755 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 553199005756 NADH dehydrogenase subunit G; Validated; Region: PRK07860 553199005757 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 553199005758 catalytic loop [active] 553199005759 iron binding site [ion binding]; other site 553199005760 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 553199005761 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 553199005762 [4Fe-4S] binding site [ion binding]; other site 553199005763 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 553199005764 molybdopterin cofactor binding site; other site 553199005765 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 553199005766 SLBB domain; Region: SLBB; pfam10531 553199005767 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 553199005768 NADH dehydrogenase subunit E; Validated; Region: PRK07539 553199005769 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 553199005770 putative dimer interface [polypeptide binding]; other site 553199005771 [2Fe-2S] cluster binding site [ion binding]; other site 553199005772 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 553199005773 NADH dehydrogenase subunit D; Validated; Region: PRK06075 553199005774 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 553199005775 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 553199005776 NADH dehydrogenase subunit B; Validated; Region: PRK06411 553199005777 NADH dehydrogenase subunit A; Validated; Region: PRK07928 553199005778 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 553199005779 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 553199005780 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539 553199005781 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 553199005782 Walker A/P-loop; other site 553199005783 ATP binding site [chemical binding]; other site 553199005784 Q-loop/lid; other site 553199005785 ABC transporter signature motif; other site 553199005786 Walker B; other site 553199005787 D-loop; other site 553199005788 H-loop/switch region; other site 553199005789 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 553199005790 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 553199005791 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 553199005792 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 553199005793 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 553199005794 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 553199005795 Walker A/P-loop; other site 553199005796 ATP binding site [chemical binding]; other site 553199005797 Q-loop/lid; other site 553199005798 ABC transporter signature motif; other site 553199005799 Walker B; other site 553199005800 D-loop; other site 553199005801 H-loop/switch region; other site 553199005802 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 553199005803 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 553199005804 Walker A/P-loop; other site 553199005805 ATP binding site [chemical binding]; other site 553199005806 Q-loop/lid; other site 553199005807 ABC transporter signature motif; other site 553199005808 Walker B; other site 553199005809 D-loop; other site 553199005810 H-loop/switch region; other site 553199005811 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 553199005812 UbiA prenyltransferase family; Region: UbiA; pfam01040 553199005813 H+ Antiporter protein; Region: 2A0121; TIGR00900 553199005814 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 553199005815 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 553199005816 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 553199005817 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 553199005818 DAK2 domain; Region: Dak2; cl03685 553199005819 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 553199005820 active pocket/dimerization site; other site 553199005821 active site 553199005822 phosphorylation site [posttranslational modification] 553199005823 Deoxycytidylate deaminase [Nucleotide transport and metabolism]; Region: ComEB; COG2131 553199005824 active site 553199005825 Zn binding site [ion binding]; other site 553199005826 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 553199005827 Cation efflux family; Region: Cation_efflux; cl00316 553199005828 A subgroup of L-lactate dehydrogenases; Region: LDH_3; cd05290 553199005829 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 553199005830 NAD binding site [chemical binding]; other site 553199005831 dimer interface [polypeptide binding]; other site 553199005832 tetramer (dimer of dimers) interface [polypeptide binding]; other site 553199005833 substrate binding site [chemical binding]; other site 553199005834 Patatin-like phospholipase; Region: Patatin; pfam01734 553199005835 active site 553199005836 nucleophile elbow; other site 553199005837 Patatin-like phospholipase; Region: Patatin; pfam01734 553199005838 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 553199005839 UMP phosphatase; Provisional; Region: PRK10444 553199005840 active site 553199005841 motif I; other site 553199005842 motif II; other site 553199005843 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 553199005844 Right handed beta helix region; Region: Beta_helix; pfam13229 553199005845 Right handed beta helix region; Region: Beta_helix; pfam13229 553199005846 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 553199005847 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 553199005848 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 553199005849 Domain of unknown function (DUF4091); Region: DUF4091; pfam13320 553199005850 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 553199005851 dimer interface [polypeptide binding]; other site 553199005852 conserved gate region; other site 553199005853 putative PBP binding loops; other site 553199005854 ABC-ATPase subunit interface; other site 553199005855 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 553199005856 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 553199005857 dimer interface [polypeptide binding]; other site 553199005858 conserved gate region; other site 553199005859 putative PBP binding loops; other site 553199005860 ABC-ATPase subunit interface; other site 553199005861 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 553199005862 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 553199005863 Bacterial SH3 domain; Region: SH3_3; pfam08239 553199005864 Bacterial SH3 domain; Region: SH3_3; cl17532 553199005865 Bacterial SH3 domain; Region: SH3_3; cl17532 553199005866 NlpC/P60 family; Region: NLPC_P60; cl17555 553199005867 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 553199005868 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 553199005869 dimer interface [polypeptide binding]; other site 553199005870 conserved gate region; other site 553199005871 putative PBP binding loops; other site 553199005872 ABC-ATPase subunit interface; other site 553199005873 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 553199005874 dimer interface [polypeptide binding]; other site 553199005875 conserved gate region; other site 553199005876 putative PBP binding loops; other site 553199005877 ABC-ATPase subunit interface; other site 553199005878 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 553199005879 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 553199005880 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 553199005881 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 553199005882 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 553199005883 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 553199005884 dimerization interface [polypeptide binding]; other site 553199005885 putative ATP binding site [chemical binding]; other site 553199005886 amidophosphoribosyltransferase; Provisional; Region: PRK07847 553199005887 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 553199005888 active site 553199005889 tetramer interface [polypeptide binding]; other site 553199005890 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 553199005891 active site 553199005892 hypothetical protein; Provisional; Region: PRK07907 553199005893 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 553199005894 active site 553199005895 metal binding site [ion binding]; metal-binding site 553199005896 dimer interface [polypeptide binding]; other site 553199005897 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 553199005898 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 553199005899 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 553199005900 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 553199005901 Glutamine amidotransferase class-I; Region: GATase; pfam00117 553199005902 glutamine binding [chemical binding]; other site 553199005903 catalytic triad [active] 553199005904 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 553199005905 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 553199005906 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 553199005907 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 553199005908 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 553199005909 dimerization interface [polypeptide binding]; other site 553199005910 ATP binding site [chemical binding]; other site 553199005911 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 553199005912 dimerization interface [polypeptide binding]; other site 553199005913 ATP binding site [chemical binding]; other site 553199005914 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 553199005915 Major Facilitator Superfamily; Region: MFS_1; pfam07690 553199005916 putative substrate translocation pore; other site 553199005917 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 553199005918 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 553199005919 Zn binding site [ion binding]; other site 553199005920 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 553199005921 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 553199005922 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 553199005923 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 553199005924 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 553199005925 active site 553199005926 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 553199005927 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 553199005928 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 553199005929 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 553199005930 active site 553199005931 catalytic triad [active] 553199005932 oxyanion hole [active] 553199005933 Thrombospondin type 3 repeat; Region: TSP_3; pfam02412 553199005934 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 553199005935 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 553199005936 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 553199005937 putative active site [active] 553199005938 catalytic triad [active] 553199005939 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 553199005940 ATP binding site [chemical binding]; other site 553199005941 active site 553199005942 substrate binding site [chemical binding]; other site 553199005943 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 553199005944 peroxiredoxin; Region: AhpC; TIGR03137 553199005945 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 553199005946 dimer interface [polypeptide binding]; other site 553199005947 decamer (pentamer of dimers) interface [polypeptide binding]; other site 553199005948 catalytic triad [active] 553199005949 peroxidatic and resolving cysteines [active] 553199005950 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 553199005951 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 553199005952 catalytic residue [active] 553199005953 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 553199005954 catalytic residues [active] 553199005955 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 553199005956 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 553199005957 Transcriptional regulator [Transcription]; Region: LysR; COG0583 553199005958 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 553199005959 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 553199005960 dimerization interface [polypeptide binding]; other site 553199005961 adenylosuccinate lyase; Region: purB; TIGR00928 553199005962 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 553199005963 tetramer interface [polypeptide binding]; other site 553199005964 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 553199005965 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 553199005966 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 553199005967 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 553199005968 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 553199005969 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 553199005970 GDP-binding site [chemical binding]; other site 553199005971 ACT binding site; other site 553199005972 IMP binding site; other site 553199005973 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 553199005974 Coenzyme A binding pocket [chemical binding]; other site 553199005975 Transcriptional regulators [Transcription]; Region: FadR; COG2186 553199005976 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 553199005977 DNA-binding site [nucleotide binding]; DNA binding site 553199005978 FCD domain; Region: FCD; pfam07729 553199005979 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 553199005980 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 553199005981 putative active site cavity [active] 553199005982 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 553199005983 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 553199005984 inhibitor site; inhibition site 553199005985 active site 553199005986 dimer interface [polypeptide binding]; other site 553199005987 catalytic residue [active] 553199005988 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 553199005989 putative sialic acid transporter; Provisional; Region: PRK03893 553199005990 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 553199005991 putative substrate translocation pore; other site 553199005992 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 553199005993 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 553199005994 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 553199005995 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 553199005996 G1 box; other site 553199005997 putative GEF interaction site [polypeptide binding]; other site 553199005998 GTP/Mg2+ binding site [chemical binding]; other site 553199005999 Switch I region; other site 553199006000 G2 box; other site 553199006001 G3 box; other site 553199006002 Switch II region; other site 553199006003 G4 box; other site 553199006004 G5 box; other site 553199006005 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 553199006006 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 553199006007 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 553199006008 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 553199006009 carboxyltransferase (CT) interaction site; other site 553199006010 biotinylation site [posttranslational modification]; other site 553199006011 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 553199006012 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 553199006013 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 553199006014 oxaloacetate decarboxylase; Provisional; Region: PRK12330 553199006015 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 553199006016 active site 553199006017 catalytic residues [active] 553199006018 metal binding site [ion binding]; metal-binding site 553199006019 homodimer binding site [polypeptide binding]; other site 553199006020 PAS domain; Region: PAS_9; pfam13426 553199006021 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 553199006022 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 553199006023 active site 553199006024 intersubunit interface [polypeptide binding]; other site 553199006025 zinc binding site [ion binding]; other site 553199006026 Na+ binding site [ion binding]; other site 553199006027 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 553199006028 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 553199006029 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 553199006030 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 553199006031 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 553199006032 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 553199006033 SEC-C motif; Region: SEC-C; pfam02810 553199006034 hypothetical protein; Provisional; Region: PRK04233 553199006035 benzoate transport; Region: 2A0115; TIGR00895 553199006036 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 553199006037 putative substrate translocation pore; other site 553199006038 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 553199006039 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 553199006040 Clp amino terminal domain; Region: Clp_N; pfam02861 553199006041 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 553199006042 Walker A motif; other site 553199006043 ATP binding site [chemical binding]; other site 553199006044 Walker B motif; other site 553199006045 arginine finger; other site 553199006046 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 553199006047 Walker A motif; other site 553199006048 ATP binding site [chemical binding]; other site 553199006049 Walker B motif; other site 553199006050 arginine finger; other site 553199006051 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 553199006052 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 553199006053 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 553199006054 Eukaryotic phosphomannomutase; Region: PMM; cl17107 553199006055 fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377 553199006056 catalytic residue [active] 553199006057 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 553199006058 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 553199006059 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 553199006060 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 553199006061 Histidine kinase; Region: HisKA_3; pfam07730 553199006062 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 553199006063 ATP binding site [chemical binding]; other site 553199006064 Mg2+ binding site [ion binding]; other site 553199006065 G-X-G motif; other site 553199006066 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 553199006067 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 553199006068 active site 553199006069 phosphorylation site [posttranslational modification] 553199006070 intermolecular recognition site; other site 553199006071 dimerization interface [polypeptide binding]; other site 553199006072 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 553199006073 DNA binding residues [nucleotide binding] 553199006074 dimerization interface [polypeptide binding]; other site 553199006075 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 553199006076 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 553199006077 Walker A/P-loop; other site 553199006078 ATP binding site [chemical binding]; other site 553199006079 Q-loop/lid; other site 553199006080 ABC transporter signature motif; other site 553199006081 Walker B; other site 553199006082 D-loop; other site 553199006083 H-loop/switch region; other site 553199006084 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 553199006085 FtsX-like permease family; Region: FtsX; pfam02687 553199006086 FtsX-like permease family; Region: FtsX; pfam02687 553199006087 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 553199006088 nudix motif; other site 553199006089 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 553199006090 Predicted permease [General function prediction only]; Region: COG2985 553199006091 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 553199006092 TrkA-C domain; Region: TrkA_C; pfam02080 553199006093 TrkA-C domain; Region: TrkA_C; pfam02080 553199006094 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 553199006095 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 553199006096 6-hydroxycyclohex-1-ene-1-carboxyl-CoA dehydrogenase, N-benzyl-3-pyrrolidinol dehydrogenase, and other MDR family members; Region: hydroxyacyl_CoA_DH; cd08254 553199006097 putative NAD(P) binding site [chemical binding]; other site 553199006098 catalytic Zn binding site [ion binding]; other site 553199006099 structural Zn binding site [ion binding]; other site 553199006100 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 553199006101 active site 553199006102 catalytic triad [active] 553199006103 oxyanion hole [active] 553199006104 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 553199006105 DNA binding residues [nucleotide binding] 553199006106 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 553199006107 putative dimer interface [polypeptide binding]; other site 553199006108 chaperone protein DnaJ; Provisional; Region: PRK14295 553199006109 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 553199006110 HSP70 interaction site [polypeptide binding]; other site 553199006111 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 553199006112 Zn binding sites [ion binding]; other site 553199006113 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 553199006114 dimer interface [polypeptide binding]; other site 553199006115 GrpE; Region: GrpE; pfam01025 553199006116 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 553199006117 dimer interface [polypeptide binding]; other site 553199006118 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 553199006119 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 553199006120 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 553199006121 nucleotide binding site [chemical binding]; other site 553199006122 NEF interaction site [polypeptide binding]; other site 553199006123 SBD interface [polypeptide binding]; other site 553199006124 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 553199006125 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 553199006126 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 553199006127 active site 553199006128 phosphorylation site [posttranslational modification] 553199006129 intermolecular recognition site; other site 553199006130 dimerization interface [polypeptide binding]; other site 553199006131 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 553199006132 DNA binding site [nucleotide binding] 553199006133 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 553199006134 intersubunit interface [polypeptide binding]; other site 553199006135 active site 553199006136 catalytic residue [active] 553199006137 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1; cd01653 553199006138 conserved cys residue [active] 553199006139 FHA domain; Region: FHA; pfam00498 553199006140 phosphopeptide binding site; other site 553199006141 pyruvate phosphate dikinase; Provisional; Region: PRK09279 553199006142 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 553199006143 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 553199006144 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 553199006145 PEP synthetase regulatory protein; Provisional; Region: PRK05339 553199006146 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 553199006147 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 553199006148 S-adenosylmethionine binding site [chemical binding]; other site 553199006149 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 553199006150 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 553199006151 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 553199006152 active site 553199006153 catalytic residues [active] 553199006154 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 553199006155 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 553199006156 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 553199006157 Amidase; Region: Amidase; cl11426 553199006158 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 553199006159 Amidase; Region: Amidase; cl11426 553199006160 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 553199006161 putative active site [active] 553199006162 homotetrameric interface [polypeptide binding]; other site 553199006163 metal binding site [ion binding]; metal-binding site 553199006164 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 553199006165 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 553199006166 active site 553199006167 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 553199006168 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 553199006169 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 553199006170 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 553199006171 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 553199006172 Walker A/P-loop; other site 553199006173 ATP binding site [chemical binding]; other site 553199006174 Q-loop/lid; other site 553199006175 ABC transporter signature motif; other site 553199006176 Walker B; other site 553199006177 D-loop; other site 553199006178 H-loop/switch region; other site 553199006179 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 553199006180 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 553199006181 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 553199006182 Walker A/P-loop; other site 553199006183 ATP binding site [chemical binding]; other site 553199006184 Q-loop/lid; other site 553199006185 ABC transporter signature motif; other site 553199006186 Walker B; other site 553199006187 D-loop; other site 553199006188 H-loop/switch region; other site 553199006189 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; cl09823 553199006190 EcsC protein family; Region: EcsC; pfam12787 553199006191 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 553199006192 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 553199006193 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 553199006194 Walker A/P-loop; other site 553199006195 ATP binding site [chemical binding]; other site 553199006196 Q-loop/lid; other site 553199006197 ABC transporter signature motif; other site 553199006198 Walker B; other site 553199006199 D-loop; other site 553199006200 H-loop/switch region; other site 553199006201 pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349 553199006202 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 553199006203 E3 interaction surface; other site 553199006204 lipoyl attachment site [posttranslational modification]; other site 553199006205 e3 binding domain; Region: E3_binding; pfam02817 553199006206 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 553199006207 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 553199006208 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 553199006209 alpha subunit interface [polypeptide binding]; other site 553199006210 TPP binding site [chemical binding]; other site 553199006211 heterodimer interface [polypeptide binding]; other site 553199006212 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 553199006213 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 553199006214 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 553199006215 TPP-binding site [chemical binding]; other site 553199006216 tetramer interface [polypeptide binding]; other site 553199006217 heterodimer interface [polypeptide binding]; other site 553199006218 phosphorylation loop region [posttranslational modification] 553199006219 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 553199006220 radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053 553199006221 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 553199006222 FeS/SAM binding site; other site 553199006223 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 553199006224 potential frameshift: common BLAST hit: gi|50843536|ref|YP_056763.1| 5'-nucleotidase/2',3'-cyclic phosphodiesterase or related esterase 553199006225 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 553199006226 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 553199006227 active site 553199006228 metal binding site [ion binding]; metal-binding site 553199006229 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 553199006230 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 553199006231 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 553199006232 H-loop/switch region; other site 553199006233 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 553199006234 WYL domain; Region: WYL; pfam13280 553199006235 HTH domain; Region: HTH_11; pfam08279 553199006236 Integrase core domain; Region: rve_3; pfam13683 553199006237 Lipase (class 2); Region: Lipase_2; pfam01674 553199006238 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 553199006239 CAMP factor (Cfa); Region: CAMP_factor; pfam07373 553199006240 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 553199006241 Low molecular weight phosphatase family; Region: LMWPc; cd00115 553199006242 active site 553199006243 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 553199006244 proposed catalytic triad [active] 553199006245 active site nucleophile [active] 553199006246 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 553199006247 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 553199006248 active site 553199006249 phosphorylation site [posttranslational modification] 553199006250 intermolecular recognition site; other site 553199006251 dimerization interface [polypeptide binding]; other site 553199006252 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 553199006253 DNA binding site [nucleotide binding] 553199006254 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 553199006255 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 553199006256 dimerization interface [polypeptide binding]; other site 553199006257 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 553199006258 dimer interface [polypeptide binding]; other site 553199006259 phosphorylation site [posttranslational modification] 553199006260 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 553199006261 ATP binding site [chemical binding]; other site 553199006262 Mg2+ binding site [ion binding]; other site 553199006263 G-X-G motif; other site 553199006264 potential frameshift: common BLAST hit: gi|50843552|ref|YP_056779.1| putative asparaginase 553199006265 Ntn-hydrolase superfamily, L-Asparaginase type 2-like enzymes. This family includes Glycosylasparaginase, Taspase 1 and L-Asparaginase type 2 enzymes. Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked...; Region: Ntn_Asparaginase_2_like; cl00635 553199006266 Ntn-hydrolase superfamily, L-Asparaginase type 2-like enzymes. This family includes Glycosylasparaginase, Taspase 1 and L-Asparaginase type 2 enzymes. Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked...; Region: Ntn_Asparaginase_2_like; cl00635 553199006267 active site 553199006268 catalytic nucleophile [active] 553199006269 dimer interface [polypeptide binding]; other site 553199006270 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 553199006271 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 553199006272 active site 553199006273 metal binding site [ion binding]; metal-binding site 553199006274 nudix motif; other site 553199006275 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 553199006276 YCII-related domain; Region: YCII; cl00999 553199006277 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 553199006278 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 553199006279 active site 553199006280 FMN binding site [chemical binding]; other site 553199006281 substrate binding site [chemical binding]; other site 553199006282 homotetramer interface [polypeptide binding]; other site 553199006283 catalytic residue [active] 553199006284 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 553199006285 putative substrate translocation pore; other site 553199006286 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK06539 553199006287 ATP cone domain; Region: ATP-cone; pfam03477 553199006288 Class I ribonucleotide reductase; Region: RNR_I; cd01679 553199006289 active site 553199006290 dimer interface [polypeptide binding]; other site 553199006291 catalytic residues [active] 553199006292 effector binding site; other site 553199006293 R2 peptide binding site; other site 553199006294 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 553199006295 dimer interface [polypeptide binding]; other site 553199006296 putative radical transfer pathway; other site 553199006297 diiron center [ion binding]; other site 553199006298 tyrosyl radical; other site 553199006299 Bacterial PH domain; Region: DUF304; pfam03703 553199006300 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 553199006301 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 553199006302 nucleotide binding site [chemical binding]; other site 553199006303 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 553199006304 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 553199006305 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 553199006306 arginine-tRNA ligase; Region: PLN02286 553199006307 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 553199006308 active site 553199006309 HIGH motif; other site 553199006310 KMSK motif region; other site 553199006311 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 553199006312 tRNA binding surface [nucleotide binding]; other site 553199006313 anticodon binding site; other site 553199006314 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 553199006315 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 553199006316 active site 553199006317 catalytic tetrad [active] 553199006318 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 553199006319 putative active site [active] 553199006320 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 553199006321 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 553199006322 active site 553199006323 dimer interface [polypeptide binding]; other site 553199006324 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 553199006325 dimer interface [polypeptide binding]; other site 553199006326 active site 553199006327 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 553199006328 active site 553199006329 intersubunit interface [polypeptide binding]; other site 553199006330 catalytic residue [active] 553199006331 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 553199006332 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 553199006333 dimerization interface [polypeptide binding]; other site 553199006334 DPS ferroxidase diiron center [ion binding]; other site 553199006335 ion pore; other site 553199006336 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 553199006337 ATP binding site [chemical binding]; other site 553199006338 putative Mg++ binding site [ion binding]; other site 553199006339 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 553199006340 nucleotide binding region [chemical binding]; other site 553199006341 ATP-binding site [chemical binding]; other site 553199006342 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 553199006343 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 553199006344 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 553199006345 FeS/SAM binding site; other site 553199006346 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK07111 553199006347 ATP cone domain; Region: ATP-cone; pfam03477 553199006348 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 553199006349 Class III ribonucleotide reductase; Region: RNR_III; cd01675 553199006350 active site 553199006351 Zn binding site [ion binding]; other site 553199006352 glycine loop; other site 553199006353 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 553199006354 substrate binding site [chemical binding]; other site 553199006355 Cutinase; Region: Cutinase; pfam01083 553199006356 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 553199006357 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 553199006358 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 553199006359 NodB motif; other site 553199006360 active site 553199006361 catalytic site [active] 553199006362 metal binding site [ion binding]; metal-binding site 553199006363 TIGR03943 family protein; Region: TIGR03943 553199006364 Predicted permease; Region: DUF318; cl17795 553199006365 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 553199006366 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 553199006367 NodB motif; other site 553199006368 active site 553199006369 catalytic site [active] 553199006370 metal binding site [ion binding]; metal-binding site 553199006371 integral membrane protein MviN; Region: mviN; TIGR01695 553199006372 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 553199006373 aspartate kinase; Reviewed; Region: PRK06635 553199006374 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 553199006375 putative nucleotide binding site [chemical binding]; other site 553199006376 putative catalytic residues [active] 553199006377 putative Mg ion binding site [ion binding]; other site 553199006378 putative aspartate binding site [chemical binding]; other site 553199006379 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 553199006380 putative allosteric regulatory site; other site 553199006381 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 553199006382 putative allosteric regulatory residue; other site 553199006383 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 553199006384 Transglycosylase; Region: Transgly; pfam00912 553199006385 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 553199006386 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 553199006387 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 553199006388 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 553199006389 putative active site [active] 553199006390 putative metal binding site [ion binding]; other site 553199006391 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 553199006392 intracellular protease, PfpI family; Region: PfpI; TIGR01382 553199006393 proposed catalytic triad [active] 553199006394 conserved cys residue [active] 553199006395 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 553199006396 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 553199006397 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 553199006398 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 553199006399 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 553199006400 ABC-ATPase subunit interface; other site 553199006401 putative PBP binding loops; other site 553199006402 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 553199006403 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 553199006404 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 553199006405 dimer interface [polypeptide binding]; other site 553199006406 conserved gate region; other site 553199006407 putative PBP binding loops; other site 553199006408 ABC-ATPase subunit interface; other site 553199006409 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 553199006410 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 553199006411 Walker A/P-loop; other site 553199006412 ATP binding site [chemical binding]; other site 553199006413 Q-loop/lid; other site 553199006414 ABC transporter signature motif; other site 553199006415 Walker B; other site 553199006416 D-loop; other site 553199006417 H-loop/switch region; other site 553199006418 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 553199006419 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 553199006420 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 553199006421 Walker A/P-loop; other site 553199006422 ATP binding site [chemical binding]; other site 553199006423 Q-loop/lid; other site 553199006424 ABC transporter signature motif; other site 553199006425 Walker B; other site 553199006426 D-loop; other site 553199006427 H-loop/switch region; other site 553199006428 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 553199006429 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 553199006430 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 553199006431 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 553199006432 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 553199006433 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 553199006434 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 553199006435 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 553199006436 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 553199006437 urocanate hydratase; Provisional; Region: PRK05414 553199006438 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 553199006439 allantoate amidohydrolase; Reviewed; Region: PRK09290 553199006440 active site 553199006441 metal binding site [ion binding]; metal-binding site 553199006442 dimer interface [polypeptide binding]; other site 553199006443 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 553199006444 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 553199006445 active site 553199006446 imidazolonepropionase; Provisional; Region: PRK14085 553199006447 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 553199006448 active site 553199006449 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 553199006450 active sites [active] 553199006451 tetramer interface [polypeptide binding]; other site 553199006452 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 553199006453 NAD-dependent deacetylase; Provisional; Region: PRK00481 553199006454 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 553199006455 NAD+ binding site [chemical binding]; other site 553199006456 substrate binding site [chemical binding]; other site 553199006457 Zn binding site [ion binding]; other site 553199006458 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 553199006459 Bacterial SH3 domain; Region: SH3_3; pfam08239 553199006460 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 553199006461 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 553199006462 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 553199006463 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 553199006464 potassium/proton antiporter; Reviewed; Region: PRK05326 553199006465 TrkA-C domain; Region: TrkA_C; pfam02080 553199006466 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 553199006467 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 553199006468 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 553199006469 nucleoside/Zn binding site; other site 553199006470 dimer interface [polypeptide binding]; other site 553199006471 catalytic motif [active] 553199006472 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 553199006473 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 553199006474 active site 553199006475 Uncharacterized conserved protein [Function unknown]; Region: COG3777 553199006476 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 553199006477 active site 553199006478 catalytic site [active] 553199006479 PA2301 is an uncharacterized Pseudomonas aeruginosa protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's...; Region: PA2301; cd04939 553199006480 putative deacylase active site [active] 553199006481 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 553199006482 K+ potassium transporter; Region: K_trans; pfam02705 553199006483 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 553199006484 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 553199006485 catalytic triad [active] 553199006486 Uncharacterized protein conserved in bacteria containing a divergent form of TPR repeats [Function unknown]; Region: COG4700 553199006487 Transcriptional regulator [Transcription]; Region: LytR; COG1316 553199006488 Transcriptional regulators [Transcription]; Region: PurR; COG1609 553199006489 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 553199006490 DNA binding site [nucleotide binding] 553199006491 domain linker motif; other site 553199006492 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 553199006493 ligand binding site [chemical binding]; other site 553199006494 dimerization interface (open form) [polypeptide binding]; other site 553199006495 dimerization interface (closed form) [polypeptide binding]; other site 553199006496 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 553199006497 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 553199006498 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u2; cd11478 553199006499 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 553199006500 Na binding site [ion binding]; other site 553199006501 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 553199006502 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 553199006503 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 553199006504 NAD(P) binding site [chemical binding]; other site 553199006505 argininosuccinate synthase; Validated; Region: PRK05370 553199006506 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 553199006507 putative substrate translocation pore; other site 553199006508 Major Facilitator Superfamily; Region: MFS_1; pfam07690 553199006509 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 553199006510 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 553199006511 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 553199006512 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 553199006513 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 553199006514 active site 553199006515 motif I; other site 553199006516 motif II; other site 553199006517 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 553199006518 thiazolylpeptide-type bacteriocin precursor; Region: thiopep_precurs; TIGR03892 553199006519 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 553199006520 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 553199006521 Walker A/P-loop; other site 553199006522 ATP binding site [chemical binding]; other site 553199006523 Q-loop/lid; other site 553199006524 ABC transporter signature motif; other site 553199006525 Walker B; other site 553199006526 D-loop; other site 553199006527 H-loop/switch region; other site 553199006528 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 553199006529 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 553199006530 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 553199006531 non-specific DNA binding site [nucleotide binding]; other site 553199006532 salt bridge; other site 553199006533 sequence-specific DNA binding site [nucleotide binding]; other site 553199006534 Cupin domain; Region: Cupin_2; pfam07883 553199006535 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 553199006536 B3/4 domain; Region: B3_4; pfam03483 553199006537 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 553199006538 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 553199006539 Na binding site [ion binding]; other site 553199006540 oxidoreductase; Provisional; Region: PRK10015 553199006541 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 553199006542 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 553199006543 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 553199006544 Ligand binding site [chemical binding]; other site 553199006545 Electron transfer flavoprotein domain; Region: ETF; pfam01012 553199006546 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 553199006547 CoA-transferase family III; Region: CoA_transf_3; pfam02515 553199006548 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 553199006549 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 553199006550 active site 553199006551 Transcriptional regulator [Transcription]; Region: IclR; COG1414 553199006552 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 553199006553 Bacterial transcriptional regulator; Region: IclR; pfam01614 553199006554 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 553199006555 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 553199006556 nucleotide binding site/active site [active] 553199006557 HIT family signature motif; other site 553199006558 catalytic residue [active] 553199006559 seryl-tRNA synthetase; Provisional; Region: PRK05431 553199006560 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 553199006561 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 553199006562 dimer interface [polypeptide binding]; other site 553199006563 active site 553199006564 motif 1; other site 553199006565 motif 2; other site 553199006566 motif 3; other site 553199006567 PRC-barrel domain; Region: PRC; pfam05239 553199006568 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 553199006569 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 553199006570 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 553199006571 phosphate binding motif [ion binding]; other site 553199006572 Siderophore-interacting protein; Region: SIP; pfam04954 553199006573 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 553199006574 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 553199006575 Ferritin-like domain; Region: Ferritin; pfam00210 553199006576 ferroxidase diiron center [ion binding]; other site 553199006577 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 553199006578 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 553199006579 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 553199006580 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 553199006581 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 553199006582 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 553199006583 dimer interface [polypeptide binding]; other site 553199006584 ssDNA binding site [nucleotide binding]; other site 553199006585 tetramer (dimer of dimers) interface [polypeptide binding]; other site 553199006586 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 553199006587 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 553199006588 active site residue [active] 553199006589 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 553199006590 active site 553199006591 phosphorylation site [posttranslational modification] 553199006592 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 553199006593 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 553199006594 active site 553199006595 P-loop; other site 553199006596 phosphorylation site [posttranslational modification] 553199006597 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 553199006598 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 553199006599 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 553199006600 acyl-activating enzyme (AAE) consensus motif; other site 553199006601 putative AMP binding site [chemical binding]; other site 553199006602 putative active site [active] 553199006603 putative CoA binding site [chemical binding]; other site 553199006604 endonuclease IV; Provisional; Region: PRK01060 553199006605 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 553199006606 AP (apurinic/apyrimidinic) site pocket; other site 553199006607 DNA interaction; other site 553199006608 Metal-binding active site; metal-binding site 553199006609 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 553199006610 classical (c) SDRs; Region: SDR_c; cd05233 553199006611 NAD(P) binding site [chemical binding]; other site 553199006612 active site 553199006613 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 553199006614 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 553199006615 putative acyl-acceptor binding pocket; other site 553199006616 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 553199006617 Domain of unknown function (DUF348); Region: DUF348; pfam03990 553199006618 Domain of unknown function (DUF348); Region: DUF348; pfam03990 553199006619 Domain of unknown function (DUF348); Region: DUF348; pfam03990 553199006620 G5 domain; Region: G5; pfam07501 553199006621 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 553199006622 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 553199006623 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 553199006624 metal-binding site [ion binding] 553199006625 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 553199006626 Soluble P-type ATPase [General function prediction only]; Region: COG4087 553199006627 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 553199006628 metal-binding site [ion binding] 553199006629 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 553199006630 putative homodimer interface [polypeptide binding]; other site 553199006631 putative homotetramer interface [polypeptide binding]; other site 553199006632 putative allosteric switch controlling residues; other site 553199006633 putative metal binding site [ion binding]; other site 553199006634 putative homodimer-homodimer interface [polypeptide binding]; other site 553199006635 replicative DNA helicase; Region: DnaB; TIGR00665 553199006636 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 553199006637 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 553199006638 Walker A motif; other site 553199006639 ATP binding site [chemical binding]; other site 553199006640 Walker B motif; other site 553199006641 DNA binding loops [nucleotide binding] 553199006642 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 553199006643 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 553199006644 putative NAD(P) binding site [chemical binding]; other site 553199006645 dimer interface [polypeptide binding]; other site 553199006646 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 553199006647 active site 553199006648 DNA binding site [nucleotide binding] 553199006649 sn-glycerol-3-phosphate dehydrogenase subunit C; Provisional; Region: glpC; PRK11168 553199006650 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 553199006651 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 553199006652 glycerol-3-phosphate dehydrogenase, anaerobic, A subunit; Region: glycerol3P_GlpA; TIGR03377 553199006653 hydroxyglutarate oxidase; Provisional; Region: PRK11728 553199006654 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 553199006655 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 553199006656 dimerization interface [polypeptide binding]; other site 553199006657 ligand binding site [chemical binding]; other site 553199006658 NADP binding site [chemical binding]; other site 553199006659 catalytic site [active] 553199006660 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 553199006661 MarR family; Region: MarR_2; cl17246 553199006662 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 553199006663 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 553199006664 Cl- selectivity filter; other site 553199006665 Cl- binding residues [ion binding]; other site 553199006666 pore gating glutamate residue; other site 553199006667 dimer interface [polypeptide binding]; other site 553199006668 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 553199006669 MarR family; Region: MarR_2; cl17246 553199006670 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 553199006671 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 553199006672 active site 553199006673 metal binding site [ion binding]; metal-binding site 553199006674 DNA binding site [nucleotide binding] 553199006675 Predicted ATPases [General function prediction only]; Region: COG1106 553199006676 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 553199006677 Uncharacterized conserved protein [Function unknown]; Region: COG4717 553199006678 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 553199006679 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 553199006680 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 553199006681 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 553199006682 WHG domain; Region: WHG; pfam13305 553199006683 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 553199006684 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 553199006685 pyridoxal 5'-phosphate binding site [chemical binding]; other site 553199006686 catalytic residue [active] 553199006687 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 553199006688 putative deacylase active site [active] 553199006689 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 553199006690 NAD synthetase; Reviewed; Region: nadE; PRK02628 553199006691 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 553199006692 multimer interface [polypeptide binding]; other site 553199006693 active site 553199006694 catalytic triad [active] 553199006695 protein interface 1 [polypeptide binding]; other site 553199006696 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 553199006697 homodimer interface [polypeptide binding]; other site 553199006698 NAD binding pocket [chemical binding]; other site 553199006699 ATP binding pocket [chemical binding]; other site 553199006700 Mg binding site [ion binding]; other site 553199006701 active-site loop [active] 553199006702 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 553199006703 6-phosphofructokinase, eukaryotic type; Region: 6PF1K_euk; TIGR02478 553199006704 active site 553199006705 ADP/pyrophosphate binding site [chemical binding]; other site 553199006706 dimerization interface [polypeptide binding]; other site 553199006707 allosteric effector site; other site 553199006708 fructose-1,6-bisphosphate binding site; other site 553199006709 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 553199006710 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 553199006711 hexamer interface [polypeptide binding]; other site 553199006712 ligand binding site [chemical binding]; other site 553199006713 putative active site [active] 553199006714 NAD(P) binding site [chemical binding]; other site 553199006715 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 553199006716 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 553199006717 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 553199006718 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 553199006719 Bacterial SH3 domain; Region: SH3_3; pfam08239 553199006720 Bacterial SH3 domain; Region: SH3_3; pfam08239 553199006721 Bacterial SH3 domain; Region: SH3_4; pfam06347 553199006722 Bacterial SH3 domain; Region: SH3_4; pfam06347 553199006723 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 553199006724 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 553199006725 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 553199006726 dimer interface [polypeptide binding]; other site 553199006727 Citrate synthase; Region: Citrate_synt; pfam00285 553199006728 active site 553199006729 citrylCoA binding site [chemical binding]; other site 553199006730 NADH binding [chemical binding]; other site 553199006731 cationic pore residues; other site 553199006732 oxalacetate/citrate binding site [chemical binding]; other site 553199006733 coenzyme A binding site [chemical binding]; other site 553199006734 catalytic triad [active] 553199006735 adenosine deaminase; Provisional; Region: PRK09358 553199006736 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 553199006737 active site 553199006738 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 553199006739 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 553199006740 hexamer interface [polypeptide binding]; other site 553199006741 ligand binding site [chemical binding]; other site 553199006742 putative active site [active] 553199006743 NAD(P) binding site [chemical binding]; other site 553199006744 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 553199006745 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 553199006746 AsnC family; Region: AsnC_trans_reg; pfam01037 553199006747 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 553199006748 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 553199006749 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 553199006750 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 553199006751 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 553199006752 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 553199006753 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 553199006754 catalytic residue [active] 553199006755 D-Lysine 5,6-aminomutase alpha subunit; Region: Lys-AminoMut_A; pfam09043 553199006756 D-Lysine 5,6-aminomutase alpha subunit; Region: Lys-AminoMut_A; pfam09043 553199006757 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 553199006758 B12 binding site [chemical binding]; other site 553199006759 MutL protein; Region: MutL; pfam13941 553199006760 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 553199006761 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815 553199006762 active site 553199006763 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 553199006764 dimer interface [polypeptide binding]; other site 553199006765 substrate binding site [chemical binding]; other site 553199006766 catalytic residue [active] 553199006767 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 553199006768 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 553199006769 alanine racemase; Reviewed; Region: alr; PRK00053 553199006770 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 553199006771 active site 553199006772 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 553199006773 dimer interface [polypeptide binding]; other site 553199006774 substrate binding site [chemical binding]; other site 553199006775 catalytic residues [active] 553199006776 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 553199006777 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 553199006778 active site 553199006779 substrate binding site [chemical binding]; other site 553199006780 metal binding site [ion binding]; metal-binding site 553199006781 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 553199006782 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 553199006783 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 553199006784 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 553199006785 active site 553199006786 Substrate binding site; other site 553199006787 Mg++ binding site; other site 553199006788 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 553199006789 putative active site [active] 553199006790 fumarate hydratase; Reviewed; Region: fumC; PRK00485 553199006791 Class II fumarases; Region: Fumarase_classII; cd01362 553199006792 active site 553199006793 tetramer interface [polypeptide binding]; other site 553199006794 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 553199006795 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 553199006796 dimer interface [polypeptide binding]; other site 553199006797 conserved gate region; other site 553199006798 putative PBP binding loops; other site 553199006799 ABC-ATPase subunit interface; other site 553199006800 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 553199006801 dimer interface [polypeptide binding]; other site 553199006802 conserved gate region; other site 553199006803 putative PBP binding loops; other site 553199006804 ABC-ATPase subunit interface; other site 553199006805 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 553199006806 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 553199006807 Transcriptional regulators [Transcription]; Region: PurR; COG1609 553199006808 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 553199006809 DNA binding site [nucleotide binding] 553199006810 domain linker motif; other site 553199006811 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 553199006812 putative dimerization interface [polypeptide binding]; other site 553199006813 putative ligand binding site [chemical binding]; other site 553199006814 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 553199006815 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 553199006816 Mechanosensitive ion channel; Region: MS_channel; pfam00924 553199006817 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 553199006818 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 553199006819 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 553199006820 active site 553199006821 NTP binding site [chemical binding]; other site 553199006822 metal binding triad [ion binding]; metal-binding site 553199006823 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 553199006824 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 553199006825 Zn2+ binding site [ion binding]; other site 553199006826 Mg2+ binding site [ion binding]; other site 553199006827 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 553199006828 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 553199006829 ATP binding site [chemical binding]; other site 553199006830 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 553199006831 glycerol kinase; Provisional; Region: glpK; PRK00047 553199006832 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 553199006833 N- and C-terminal domain interface [polypeptide binding]; other site 553199006834 active site 553199006835 MgATP binding site [chemical binding]; other site 553199006836 catalytic site [active] 553199006837 metal binding site [ion binding]; metal-binding site 553199006838 putative homotetramer interface [polypeptide binding]; other site 553199006839 glycerol binding site [chemical binding]; other site 553199006840 homodimer interface [polypeptide binding]; other site 553199006841 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 553199006842 amphipathic channel; other site 553199006843 Asn-Pro-Ala signature motifs; other site 553199006844 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 553199006845 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 553199006846 DNA binding residues [nucleotide binding] 553199006847 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 553199006848 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 553199006849 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 553199006850 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 553199006851 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 553199006852 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 553199006853 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 553199006854 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 553199006855 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 553199006856 probable active site [active] 553199006857 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 553199006858 putative substrate translocation pore; other site 553199006859 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 553199006860 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 553199006861 substrate binding pocket [chemical binding]; other site 553199006862 OsmC-like protein; Region: OsmC; pfam02566 553199006863 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 553199006864 catalytic residues [active] 553199006865 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 553199006866 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 553199006867 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 553199006868 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 553199006869 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 553199006870 non-specific DNA interactions [nucleotide binding]; other site 553199006871 DNA binding site [nucleotide binding] 553199006872 sequence specific DNA binding site [nucleotide binding]; other site 553199006873 putative cAMP binding site [chemical binding]; other site 553199006874 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 553199006875 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 553199006876 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 553199006877 TPP-binding site [chemical binding]; other site 553199006878 dimer interface [polypeptide binding]; other site 553199006879 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 553199006880 PYR/PP interface [polypeptide binding]; other site 553199006881 dimer interface [polypeptide binding]; other site 553199006882 TPP binding site [chemical binding]; other site 553199006883 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 553199006884 ribulokinase; Provisional; Region: PRK04123 553199006885 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 553199006886 N- and C-terminal domain interface [polypeptide binding]; other site 553199006887 active site 553199006888 MgATP binding site [chemical binding]; other site 553199006889 catalytic site [active] 553199006890 metal binding site [ion binding]; metal-binding site 553199006891 carbohydrate binding site [chemical binding]; other site 553199006892 homodimer interface [polypeptide binding]; other site 553199006893 Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175 553199006894 active site 553199006895 metal binding site [ion binding]; metal-binding site 553199006896 Carbohydrate kinase and ribulose-phosphate 3-epimerase fusion proteins-like; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CarbK-RPE_like; cd07783 553199006897 Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069 553199006898 N- and C-terminal domain interface [polypeptide binding]; other site 553199006899 active site 553199006900 MgATP binding site [chemical binding]; other site 553199006901 catalytic site [active] 553199006902 metal binding site [ion binding]; metal-binding site 553199006903 putative carbohydrate binding site [chemical binding]; other site 553199006904 putative homodimer interface [polypeptide binding]; other site 553199006905 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 553199006906 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 553199006907 active site 553199006908 motif I; other site 553199006909 motif II; other site 553199006910 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 553199006911 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 553199006912 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 553199006913 active site 553199006914 Zn2+ binding site [ion binding]; other site 553199006915 intersubunit interface [polypeptide binding]; other site 553199006916 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 553199006917 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 553199006918 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 553199006919 mannonate dehydratase; Provisional; Region: PRK03906 553199006920 mannonate dehydratase; Region: uxuA; TIGR00695 553199006921 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 553199006922 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 553199006923 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 553199006924 glucuronate isomerase; Reviewed; Region: PRK02925 553199006925 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 553199006926 Transcriptional regulators [Transcription]; Region: PurR; COG1609 553199006927 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 553199006928 DNA binding site [nucleotide binding] 553199006929 domain linker motif; other site 553199006930 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 553199006931 dimerization interface [polypeptide binding]; other site 553199006932 ligand binding site [chemical binding]; other site 553199006933 MFS/sugar transport protein; Region: MFS_2; pfam13347 553199006934 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 553199006935 putative alpha-glucosidase; Provisional; Region: PRK10658 553199006936 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 553199006937 Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599 553199006938 putative active site [active] 553199006939 putative catalytic site [active] 553199006940 beta-D-glucuronidase; Provisional; Region: PRK10150 553199006941 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 553199006942 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 553199006943 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 553199006944 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 553199006945 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 553199006946 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 553199006947 pyridoxal 5'-phosphate binding site [chemical binding]; other site 553199006948 homodimer interface [polypeptide binding]; other site 553199006949 catalytic residue [active] 553199006950 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 553199006951 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 553199006952 ATP-grasp domain; Region: ATP-grasp_4; cl17255 553199006953 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 553199006954 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 553199006955 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 553199006956 ParB-like nuclease domain; Region: ParB; smart00470 553199006957 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 553199006958 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 553199006959 P-loop; other site 553199006960 Magnesium ion binding site [ion binding]; other site 553199006961 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 553199006962 Magnesium ion binding site [ion binding]; other site 553199006963 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 553199006964 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 553199006965 Alanine racemase, N-terminal domain; Region: Ala_racemase_N; pfam01168 553199006966 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 553199006967 catalytic residue [active] 553199006968 FemAB family; Region: FemAB; pfam02388 553199006969 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 553199006970 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 553199006971 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 553199006972 G-X-X-G motif; other site 553199006973 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 553199006974 RxxxH motif; other site 553199006975 putative inner membrane protein translocase component YidC; Provisional; Region: PRK01315 553199006976 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 553199006977 Ribonuclease P; Region: Ribonuclease_P; cl00457 553199006978 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399