-- dump date 20140620_001004 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1114967000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1114967000002 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 1114967000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114967000004 Walker A motif; other site 1114967000005 ATP binding site [chemical binding]; other site 1114967000006 Walker B motif; other site 1114967000007 arginine finger; other site 1114967000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1114967000009 DnaA box-binding interface [nucleotide binding]; other site 1114967000010 DNA polymerase III subunit beta; Validated; Region: PRK07761 1114967000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1114967000012 putative DNA binding surface [nucleotide binding]; other site 1114967000013 dimer interface [polypeptide binding]; other site 1114967000014 beta-clamp/clamp loader binding surface; other site 1114967000015 beta-clamp/translesion DNA polymerase binding surface; other site 1114967000016 recombination protein F; Reviewed; Region: recF; PRK00064 1114967000017 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114967000018 Walker A/P-loop; other site 1114967000019 ATP binding site [chemical binding]; other site 1114967000020 Q-loop/lid; other site 1114967000021 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114967000022 ABC transporter signature motif; other site 1114967000023 Walker B; other site 1114967000024 D-loop; other site 1114967000025 H-loop/switch region; other site 1114967000026 Protein of unknown function (DUF721); Region: DUF721; cl02324 1114967000027 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114967000028 ABC transporter signature motif; other site 1114967000029 Walker B; other site 1114967000030 D-loop; other site 1114967000031 H-loop/switch region; other site 1114967000032 potential frameshift: common BLAST hit: gi|29375676|ref|NP_814830.1| ABC transporter ATP-binding protein/permease 1114967000033 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 1114967000034 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 1114967000035 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1114967000036 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1114967000037 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1114967000038 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114967000039 Mg2+ binding site [ion binding]; other site 1114967000040 G-X-G motif; other site 1114967000041 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1114967000042 anchoring element; other site 1114967000043 dimer interface [polypeptide binding]; other site 1114967000044 ATP binding site [chemical binding]; other site 1114967000045 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1114967000046 active site 1114967000047 putative metal-binding site [ion binding]; other site 1114967000048 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1114967000049 DNA gyrase subunit A; Validated; Region: PRK05560 1114967000050 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1114967000051 CAP-like domain; other site 1114967000052 active site 1114967000053 primary dimer interface [polypeptide binding]; other site 1114967000054 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1114967000055 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1114967000056 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1114967000057 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1114967000058 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1114967000059 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 1114967000060 A subgroup of L-lactate dehydrogenases; Region: LDH_3; cd05290 1114967000061 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 1114967000062 NAD binding site [chemical binding]; other site 1114967000063 dimer interface [polypeptide binding]; other site 1114967000064 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1114967000065 substrate binding site [chemical binding]; other site 1114967000066 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1114967000067 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1114967000068 DNA binding site [nucleotide binding] 1114967000069 domain linker motif; other site 1114967000070 Ligand-binding domain of DNA-binding regulatory protein from Corynebacterium glutamicum which has a unique ability to produce significant amounts of L-glutamate directly from cheap sugar and ammonia; Region: PBP1_LacI_like_13; cd06299 1114967000071 dimerization interface [polypeptide binding]; other site 1114967000072 putative ligand binding site [chemical binding]; other site 1114967000073 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1114967000074 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1114967000075 Walker A/P-loop; other site 1114967000076 ATP binding site [chemical binding]; other site 1114967000077 Q-loop/lid; other site 1114967000078 ABC transporter signature motif; other site 1114967000079 Walker B; other site 1114967000080 D-loop; other site 1114967000081 H-loop/switch region; other site 1114967000082 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1114967000083 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1114967000084 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1114967000085 TM-ABC transporter signature motif; other site 1114967000086 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 1114967000087 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1114967000088 ligand binding site [chemical binding]; other site 1114967000089 dimerization interface [polypeptide binding]; other site 1114967000090 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1114967000091 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1114967000092 substrate binding site [chemical binding]; other site 1114967000093 dimer interface [polypeptide binding]; other site 1114967000094 ATP binding site [chemical binding]; other site 1114967000095 D-ribose pyranase; Provisional; Region: PRK11797 1114967000096 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1114967000097 active site 1114967000098 phosphorylation site [posttranslational modification] 1114967000099 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 1114967000100 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 1114967000101 active site 1114967000102 P-loop; other site 1114967000103 phosphorylation site [posttranslational modification] 1114967000104 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1114967000105 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1114967000106 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1114967000107 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1114967000108 HTH domain; Region: HTH_11; cl17392 1114967000109 PRD domain; Region: PRD; pfam00874 1114967000110 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1114967000111 active site 1114967000112 phosphorylation site [posttranslational modification] 1114967000113 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1114967000114 haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549 1114967000115 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1114967000116 active site 1114967000117 motif I; other site 1114967000118 motif II; other site 1114967000119 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1114967000120 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1114967000121 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1114967000122 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 1114967000123 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1114967000124 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114967000125 homodimer interface [polypeptide binding]; other site 1114967000126 catalytic residue [active] 1114967000127 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 1114967000128 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 1114967000129 active site 1114967000130 nucleophile elbow; other site 1114967000131 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1114967000132 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1114967000133 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 1114967000134 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 1114967000135 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1114967000136 Walker A motif; other site 1114967000137 ATP binding site [chemical binding]; other site 1114967000138 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1114967000139 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1114967000140 Bacterial transcriptional activator domain; Region: BTAD; smart01043 1114967000141 H+ Antiporter protein; Region: 2A0121; TIGR00900 1114967000142 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 1114967000143 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 1114967000144 Potassium binding sites [ion binding]; other site 1114967000145 Cesium cation binding sites [ion binding]; other site 1114967000146 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 1114967000147 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1114967000148 FtsX-like permease family; Region: FtsX; pfam02687 1114967000149 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1114967000150 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1114967000151 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1114967000152 Walker A/P-loop; other site 1114967000153 ATP binding site [chemical binding]; other site 1114967000154 Q-loop/lid; other site 1114967000155 ABC transporter signature motif; other site 1114967000156 Walker B; other site 1114967000157 D-loop; other site 1114967000158 H-loop/switch region; other site 1114967000159 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1114967000160 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114967000161 active site 1114967000162 phosphorylation site [posttranslational modification] 1114967000163 intermolecular recognition site; other site 1114967000164 dimerization interface [polypeptide binding]; other site 1114967000165 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1114967000166 DNA binding residues [nucleotide binding] 1114967000167 dimerization interface [polypeptide binding]; other site 1114967000168 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1114967000169 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114967000170 dimer interface [polypeptide binding]; other site 1114967000171 conserved gate region; other site 1114967000172 putative PBP binding loops; other site 1114967000173 ABC-ATPase subunit interface; other site 1114967000174 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1114967000175 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114967000176 dimer interface [polypeptide binding]; other site 1114967000177 conserved gate region; other site 1114967000178 putative PBP binding loops; other site 1114967000179 ABC-ATPase subunit interface; other site 1114967000180 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1114967000181 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1114967000182 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1114967000183 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1114967000184 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1114967000185 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1114967000186 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 1114967000187 NAD binding site [chemical binding]; other site 1114967000188 sugar binding site [chemical binding]; other site 1114967000189 divalent metal binding site [ion binding]; other site 1114967000190 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1114967000191 dimer interface [polypeptide binding]; other site 1114967000192 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 1114967000193 active site 1114967000194 catalytic site [active] 1114967000195 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 1114967000196 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 1114967000197 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 1114967000198 Sulfatase; Region: Sulfatase; cl17466 1114967000199 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 1114967000200 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114967000201 motif II; other site 1114967000202 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 1114967000203 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 1114967000204 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 1114967000205 active site 1114967000206 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1114967000207 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1114967000208 substrate binding site [chemical binding]; other site 1114967000209 ATP binding site [chemical binding]; other site 1114967000210 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1114967000211 Histidine kinase; Region: HisKA_3; pfam07730 1114967000212 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114967000213 ATP binding site [chemical binding]; other site 1114967000214 Mg2+ binding site [ion binding]; other site 1114967000215 G-X-G motif; other site 1114967000216 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1114967000217 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114967000218 NAD(P) binding site [chemical binding]; other site 1114967000219 active site 1114967000220 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114967000221 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1114967000222 MMPL family; Region: MMPL; pfam03176 1114967000223 MMPL family; Region: MMPL; pfam03176 1114967000224 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1114967000225 Predicted membrane protein [Function unknown]; Region: COG1511 1114967000226 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1114967000227 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1114967000228 Walker A/P-loop; other site 1114967000229 ATP binding site [chemical binding]; other site 1114967000230 Q-loop/lid; other site 1114967000231 ABC transporter signature motif; other site 1114967000232 Walker B; other site 1114967000233 D-loop; other site 1114967000234 H-loop/switch region; other site 1114967000235 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114967000236 S-adenosylmethionine binding site [chemical binding]; other site 1114967000237 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 1114967000238 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 1114967000239 putative ligand binding residues [chemical binding]; other site 1114967000240 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1114967000241 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1114967000242 ABC-ATPase subunit interface; other site 1114967000243 dimer interface [polypeptide binding]; other site 1114967000244 putative PBP binding regions; other site 1114967000245 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1114967000246 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1114967000247 ABC transporter signature motif; other site 1114967000248 Walker B; other site 1114967000249 D-loop; other site 1114967000250 H-loop/switch region; other site 1114967000251 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1114967000252 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1114967000253 tetramerization interface [polypeptide binding]; other site 1114967000254 NAD(P) binding site [chemical binding]; other site 1114967000255 catalytic residues [active] 1114967000256 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1114967000257 Putative ClC chloride channel. Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033 1114967000258 putative ion selectivity filter; other site 1114967000259 putative pore gating glutamate residue; other site 1114967000260 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1114967000261 homodimer interface [polypeptide binding]; other site 1114967000262 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 1114967000263 active site pocket [active] 1114967000264 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1114967000265 DNA binding residues [nucleotide binding] 1114967000266 Lacto-N-biose phosphorylase; Region: Lact_bio_phlase; pfam09508 1114967000267 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase; Region: TIGR02336 1114967000268 MarR family; Region: MarR_2; pfam12802 1114967000269 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1114967000270 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1114967000271 carbohydrate ABC transporter substrate-binding protein, CPR_0540 family; Region: bind_CPR_0540; TIGR03850 1114967000272 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1114967000273 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1114967000274 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114967000275 dimer interface [polypeptide binding]; other site 1114967000276 conserved gate region; other site 1114967000277 putative PBP binding loops; other site 1114967000278 ABC-ATPase subunit interface; other site 1114967000279 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1114967000280 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114967000281 dimer interface [polypeptide binding]; other site 1114967000282 conserved gate region; other site 1114967000283 putative PBP binding loops; other site 1114967000284 ABC-ATPase subunit interface; other site 1114967000285 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1114967000286 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1114967000287 DNA binding site [nucleotide binding] 1114967000288 domain linker motif; other site 1114967000289 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 1114967000290 ligand binding site [chemical binding]; other site 1114967000291 dimerization interface (open form) [polypeptide binding]; other site 1114967000292 dimerization interface (closed form) [polypeptide binding]; other site 1114967000293 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1114967000294 6-phosphofructokinase; Provisional; Region: PRK03202 1114967000295 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1114967000296 active site 1114967000297 ADP/pyrophosphate binding site [chemical binding]; other site 1114967000298 dimerization interface [polypeptide binding]; other site 1114967000299 allosteric effector site; other site 1114967000300 fructose-1,6-bisphosphate binding site; other site 1114967000301 Predicted transcriptional regulator [Transcription]; Region: COG2345 1114967000302 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1114967000303 putative DNA binding site [nucleotide binding]; other site 1114967000304 putative Zn2+ binding site [ion binding]; other site 1114967000305 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 1114967000306 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 1114967000307 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1114967000308 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1114967000309 Aspartase; Region: Aspartase; cd01357 1114967000310 active sites [active] 1114967000311 tetramer interface [polypeptide binding]; other site 1114967000312 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 1114967000313 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 1114967000314 Predicted acetyltransferase [General function prediction only]; Region: COG2388 1114967000315 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1114967000316 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 1114967000317 heme binding pocket [chemical binding]; other site 1114967000318 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1114967000319 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1114967000320 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114967000321 Walker A/P-loop; other site 1114967000322 ATP binding site [chemical binding]; other site 1114967000323 Q-loop/lid; other site 1114967000324 ABC transporter signature motif; other site 1114967000325 Walker B; other site 1114967000326 D-loop; other site 1114967000327 H-loop/switch region; other site 1114967000328 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1114967000329 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1114967000330 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114967000331 Q-loop/lid; other site 1114967000332 ABC transporter signature motif; other site 1114967000333 Walker B; other site 1114967000334 D-loop; other site 1114967000335 H-loop/switch region; other site 1114967000336 Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081 1114967000337 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1114967000338 Walker A motif; other site 1114967000339 ATP binding site [chemical binding]; other site 1114967000340 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 1114967000341 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1114967000342 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 1114967000343 metal ion-dependent adhesion site (MIDAS); other site 1114967000344 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1114967000345 CobN/Magnesium Chelatase; Region: CobN-Mg_chel; pfam02514 1114967000346 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1114967000347 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1114967000348 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1114967000349 FeS/SAM binding site; other site 1114967000350 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1114967000351 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1114967000352 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1114967000353 Walker A/P-loop; other site 1114967000354 ATP binding site [chemical binding]; other site 1114967000355 Q-loop/lid; other site 1114967000356 ABC transporter signature motif; other site 1114967000357 Walker B; other site 1114967000358 D-loop; other site 1114967000359 H-loop/switch region; other site 1114967000360 FecCD transport family; Region: FecCD; pfam01032 1114967000361 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1114967000362 ABC-ATPase subunit interface; other site 1114967000363 dimer interface [polypeptide binding]; other site 1114967000364 putative PBP binding regions; other site 1114967000365 Periplasmic binding protein TroA_d. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_d; cd01141 1114967000366 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1114967000367 putative ligand binding site [chemical binding]; other site 1114967000368 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1114967000369 Periplasmic binding protein TroA_d. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_d; cd01141 1114967000370 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1114967000371 putative ligand binding site [chemical binding]; other site 1114967000372 myosin-cross-reactive antigen; Provisional; Region: PRK13977 1114967000373 multifunctional hydroxymethylpyrimidine phosphokinase/4-amino-5-aminomethyl-2-methylpyrimidine hydrolase; Provisional; Region: PRK14713 1114967000374 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1114967000375 dimer interface [polypeptide binding]; other site 1114967000376 substrate binding site [chemical binding]; other site 1114967000377 ATP binding site [chemical binding]; other site 1114967000378 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 1114967000379 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1114967000380 thiamine phosphate binding site [chemical binding]; other site 1114967000381 active site 1114967000382 pyrophosphate binding site [ion binding]; other site 1114967000383 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1114967000384 putative active site [active] 1114967000385 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 1114967000386 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 1114967000387 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1114967000388 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1114967000389 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 1114967000390 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1114967000391 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1114967000392 Ligand Binding Site [chemical binding]; other site 1114967000393 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114967000394 dimer interface [polypeptide binding]; other site 1114967000395 phosphorylation site [posttranslational modification] 1114967000396 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114967000397 ATP binding site [chemical binding]; other site 1114967000398 Mg2+ binding site [ion binding]; other site 1114967000399 G-X-G motif; other site 1114967000400 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1114967000401 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114967000402 active site 1114967000403 phosphorylation site [posttranslational modification] 1114967000404 intermolecular recognition site; other site 1114967000405 dimerization interface [polypeptide binding]; other site 1114967000406 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1114967000407 DNA binding site [nucleotide binding] 1114967000408 EXLDI protein; Region: EXLDI; TIGR04342 1114967000409 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1114967000410 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1114967000411 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1114967000412 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1114967000413 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1114967000414 Transglycosylase; Region: Transgly; pfam00912 1114967000415 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1114967000416 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1114967000417 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 1114967000418 Mannosyltransferase (PIG-V)); Region: Mannosyl_trans2; pfam04188 1114967000419 potential frameshift: common BLAST hit: gi|50841619|ref|YP_054846.1| glycosyl transferase 1114967000420 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1114967000421 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1114967000422 O-Antigen ligase; Region: Wzy_C; pfam04932 1114967000423 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 1114967000424 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1114967000425 putative trimer interface [polypeptide binding]; other site 1114967000426 putative CoA binding site [chemical binding]; other site 1114967000427 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 1114967000428 putative trimer interface [polypeptide binding]; other site 1114967000429 putative active site [active] 1114967000430 putative substrate binding site [chemical binding]; other site 1114967000431 putative CoA binding site [chemical binding]; other site 1114967000432 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1114967000433 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1114967000434 inhibitor-cofactor binding pocket; inhibition site 1114967000435 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114967000436 catalytic residue [active] 1114967000437 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1114967000438 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1114967000439 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1114967000440 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 1114967000441 O-Antigen ligase; Region: Wzy_C; pfam04932 1114967000442 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1114967000443 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114967000444 POT family; Region: PTR2; cl17359 1114967000445 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1114967000446 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1114967000447 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1114967000448 classical (c) SDRs; Region: SDR_c; cd05233 1114967000449 NAD(P) binding site [chemical binding]; other site 1114967000450 active site 1114967000451 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1114967000452 dimerization domain swap beta strand [polypeptide binding]; other site 1114967000453 regulatory protein interface [polypeptide binding]; other site 1114967000454 active site 1114967000455 regulatory phosphorylation site [posttranslational modification]; other site 1114967000456 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1114967000457 active site 1114967000458 phosphorylation site [posttranslational modification] 1114967000459 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1114967000460 active site 1114967000461 P-loop; other site 1114967000462 phosphorylation site [posttranslational modification] 1114967000463 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1114967000464 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1114967000465 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1114967000466 putative substrate binding site [chemical binding]; other site 1114967000467 putative ATP binding site [chemical binding]; other site 1114967000468 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1114967000469 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1114967000470 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1114967000471 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 1114967000472 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1114967000473 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1114967000474 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1114967000475 O-Antigen ligase; Region: Wzy_C; pfam04932 1114967000476 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1114967000477 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 1114967000478 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1114967000479 active site 1114967000480 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 1114967000481 homodimer interface [polypeptide binding]; other site 1114967000482 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1114967000483 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1114967000484 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1114967000485 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1114967000486 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1114967000487 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1114967000488 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 1114967000489 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1114967000490 ATP binding site [chemical binding]; other site 1114967000491 putative Mg++ binding site [ion binding]; other site 1114967000492 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1114967000493 nucleotide binding region [chemical binding]; other site 1114967000494 ATP-binding site [chemical binding]; other site 1114967000495 Helicase associated domain (HA2); Region: HA2; pfam04408 1114967000496 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 1114967000497 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 1114967000498 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1114967000499 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1114967000500 Walker A/P-loop; other site 1114967000501 ATP binding site [chemical binding]; other site 1114967000502 Q-loop/lid; other site 1114967000503 ABC transporter signature motif; other site 1114967000504 Walker B; other site 1114967000505 D-loop; other site 1114967000506 H-loop/switch region; other site 1114967000507 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114967000508 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 1114967000509 Walker A/P-loop; other site 1114967000510 ATP binding site [chemical binding]; other site 1114967000511 Q-loop/lid; other site 1114967000512 ABC transporter signature motif; other site 1114967000513 Walker B; other site 1114967000514 D-loop; other site 1114967000515 H-loop/switch region; other site 1114967000516 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1114967000517 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1114967000518 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 1114967000519 Predicted membrane protein [Function unknown]; Region: COG4270 1114967000520 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565 1114967000521 Dihydroorotate dehydrogenase (DHOD) like proteins. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_like; cd04739 1114967000522 putative active site [active] 1114967000523 putative FMN binding site [chemical binding]; other site 1114967000524 putative substrate binding site [chemical binding]; other site 1114967000525 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 1114967000526 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1114967000527 dimer interface [polypeptide binding]; other site 1114967000528 PYR/PP interface [polypeptide binding]; other site 1114967000529 TPP binding site [chemical binding]; other site 1114967000530 substrate binding site [chemical binding]; other site 1114967000531 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1114967000532 Domain of unknown function; Region: EKR; smart00890 1114967000533 4Fe-4S binding domain; Region: Fer4_6; pfam12837 1114967000534 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1114967000535 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 1114967000536 TPP-binding site [chemical binding]; other site 1114967000537 dimer interface [polypeptide binding]; other site 1114967000538 putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771 1114967000539 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1114967000540 4Fe-4S binding domain; Region: Fer4; pfam00037 1114967000541 Domain of unknown function DUF77; Region: DUF77; pfam01910 1114967000542 potential frameshift: common BLAST hit: gi|50841653|ref|YP_054880.1| regulator protein 1114967000543 L-lactate permease; Region: Lactate_perm; cl00701 1114967000544 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 1114967000545 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1114967000546 Cysteine-rich domain; Region: CCG; pfam02754 1114967000547 Cysteine-rich domain; Region: CCG; pfam02754 1114967000548 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 1114967000549 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1114967000550 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1114967000551 Uncharacterized conserved protein [Function unknown]; Region: COG1556 1114967000552 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 1114967000553 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1114967000554 Walker A/P-loop; other site 1114967000555 ATP binding site [chemical binding]; other site 1114967000556 Q-loop/lid; other site 1114967000557 ABC transporter signature motif; other site 1114967000558 Walker B; other site 1114967000559 D-loop; other site 1114967000560 H-loop/switch region; other site 1114967000561 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 1114967000562 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1114967000563 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1114967000564 Walker A/P-loop; other site 1114967000565 ATP binding site [chemical binding]; other site 1114967000566 Q-loop/lid; other site 1114967000567 ABC transporter signature motif; other site 1114967000568 Walker B; other site 1114967000569 D-loop; other site 1114967000570 H-loop/switch region; other site 1114967000571 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1114967000572 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1114967000573 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1114967000574 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1114967000575 Amino acid permease; Region: AA_permease_2; pfam13520 1114967000576 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1114967000577 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1114967000578 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1114967000579 Walker A/P-loop; other site 1114967000580 ATP binding site [chemical binding]; other site 1114967000581 Q-loop/lid; other site 1114967000582 ABC transporter signature motif; other site 1114967000583 Walker B; other site 1114967000584 D-loop; other site 1114967000585 H-loop/switch region; other site 1114967000586 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1114967000587 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1114967000588 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114967000589 Walker A/P-loop; other site 1114967000590 ATP binding site [chemical binding]; other site 1114967000591 Q-loop/lid; other site 1114967000592 ABC transporter signature motif; other site 1114967000593 Walker B; other site 1114967000594 D-loop; other site 1114967000595 H-loop/switch region; other site 1114967000596 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1114967000597 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1114967000598 non-specific DNA binding site [nucleotide binding]; other site 1114967000599 salt bridge; other site 1114967000600 sequence-specific DNA binding site [nucleotide binding]; other site 1114967000601 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1114967000602 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1114967000603 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1114967000604 dimer interface [polypeptide binding]; other site 1114967000605 putative anticodon binding site; other site 1114967000606 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1114967000607 motif 1; other site 1114967000608 dimer interface [polypeptide binding]; other site 1114967000609 active site 1114967000610 motif 2; other site 1114967000611 motif 3; other site 1114967000612 Uncharacterized protein family (UPF0233); Region: UPF0233; pfam06781 1114967000613 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1114967000614 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1114967000615 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1114967000616 active site 1114967000617 ATP binding site [chemical binding]; other site 1114967000618 substrate binding site [chemical binding]; other site 1114967000619 activation loop (A-loop); other site 1114967000620 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1114967000621 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1114967000622 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1114967000623 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1114967000624 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 1114967000625 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1114967000626 active site 1114967000627 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1114967000628 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1114967000629 phosphopeptide binding site; other site 1114967000630 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 1114967000631 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1114967000632 phosphopeptide binding site; other site 1114967000633 Phosphotransferase enzyme family; Region: APH; pfam01636 1114967000634 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1114967000635 active site 1114967000636 ATP binding site [chemical binding]; other site 1114967000637 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1114967000638 RHS Repeat; Region: RHS_repeat; pfam05593 1114967000639 RHS Repeat; Region: RHS_repeat; cl11982 1114967000640 RHS Repeat; Region: RHS_repeat; cl11982 1114967000641 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1114967000642 RHS Repeat; Region: RHS_repeat; cl11982 1114967000643 RHS Repeat; Region: RHS_repeat; pfam05593 1114967000644 RHS Repeat; Region: RHS_repeat; pfam05593 1114967000645 RHS Repeat; Region: RHS_repeat; pfam05593 1114967000646 RHS Repeat; Region: RHS_repeat; cl11982 1114967000647 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 1114967000648 RHS Repeat; Region: RHS_repeat; cl11982 1114967000649 potential frameshift: common BLAST hit: gi|311112673|ref|YP_003983895.1| serine/threonine-protein kinase PkaA 1114967000650 potential frameshift: common BLAST hit: gi|295129766|ref|YP_003580429.1| RHS repeat-associated core domain protein 1114967000651 potential frameshift: common BLAST hit: gi|295129767|ref|YP_003580430.1| YD repeat protein 1114967000652 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1114967000653 RNA binding surface [nucleotide binding]; other site 1114967000654 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 1114967000655 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114967000656 Walker A motif; other site 1114967000657 ATP binding site [chemical binding]; other site 1114967000658 Walker B motif; other site 1114967000659 arginine finger; other site 1114967000660 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1114967000661 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG0718 1114967000662 recombination protein RecR; Reviewed; Region: recR; PRK00076 1114967000663 RecR protein; Region: RecR; pfam02132 1114967000664 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1114967000665 putative active site [active] 1114967000666 putative metal-binding site [ion binding]; other site 1114967000667 tetramer interface [polypeptide binding]; other site 1114967000668 Predicted transcriptional regulators [Transcription]; Region: COG1695 1114967000669 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1114967000670 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1114967000671 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1114967000672 Walker A/P-loop; other site 1114967000673 ATP binding site [chemical binding]; other site 1114967000674 Q-loop/lid; other site 1114967000675 ABC transporter signature motif; other site 1114967000676 Walker B; other site 1114967000677 D-loop; other site 1114967000678 H-loop/switch region; other site 1114967000679 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1114967000680 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1114967000681 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1114967000682 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 1114967000683 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1114967000684 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114967000685 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1114967000686 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114967000687 active site 1114967000688 motif I; other site 1114967000689 motif II; other site 1114967000690 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114967000691 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1114967000692 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 1114967000693 Walker A/P-loop; other site 1114967000694 ATP binding site [chemical binding]; other site 1114967000695 Q-loop/lid; other site 1114967000696 ABC transporter signature motif; other site 1114967000697 Walker B; other site 1114967000698 D-loop; other site 1114967000699 H-loop/switch region; other site 1114967000700 Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060 1114967000701 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1114967000702 active site 1114967000703 HIGH motif; other site 1114967000704 nucleotide binding site [chemical binding]; other site 1114967000705 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1114967000706 active site 1114967000707 KMSKS motif; other site 1114967000708 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 1114967000709 tRNA binding surface [nucleotide binding]; other site 1114967000710 anticodon binding site; other site 1114967000711 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 1114967000712 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1114967000713 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 1114967000714 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1114967000715 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1114967000716 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1114967000717 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 1114967000718 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 1114967000719 homotrimer interaction site [polypeptide binding]; other site 1114967000720 putative active site [active] 1114967000721 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1114967000722 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1114967000723 ligand binding site [chemical binding]; other site 1114967000724 flexible hinge region; other site 1114967000725 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1114967000726 putative switch regulator; other site 1114967000727 non-specific DNA interactions [nucleotide binding]; other site 1114967000728 DNA binding site [nucleotide binding] 1114967000729 sequence specific DNA binding site [nucleotide binding]; other site 1114967000730 putative cAMP binding site [chemical binding]; other site 1114967000731 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1114967000732 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1114967000733 minor groove reading motif; other site 1114967000734 helix-hairpin-helix signature motif; other site 1114967000735 substrate binding pocket [chemical binding]; other site 1114967000736 active site 1114967000737 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1114967000738 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1114967000739 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1114967000740 catalytic residues [active] 1114967000741 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1114967000742 putative active site [active] 1114967000743 putative CoA binding site [chemical binding]; other site 1114967000744 nudix motif; other site 1114967000745 metal binding site [ion binding]; metal-binding site 1114967000746 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 1114967000747 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1114967000748 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 1114967000749 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 1114967000750 helicase/secretion neighborhood ATPase; Region: heli_sec_ATPase; TIGR03819 1114967000751 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 1114967000752 Walker A motif; other site 1114967000753 ATP binding site [chemical binding]; other site 1114967000754 Walker B motif; other site 1114967000755 potential frameshift: common BLAST hit: gi|295129802|ref|YP_003580465.1| type II secretion system F domain protein 1114967000756 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 1114967000757 helicase/secretion neighborhood TadE-like protein; Region: tadE_like_DECH; TIGR03816 1114967000758 Predicted ATPase [General function prediction only]; Region: COG4637 1114967000759 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 1114967000760 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1114967000761 ATP binding site [chemical binding]; other site 1114967000762 putative Mg++ binding site [ion binding]; other site 1114967000763 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1114967000764 nucleotide binding region [chemical binding]; other site 1114967000765 ATP-binding site [chemical binding]; other site 1114967000766 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1114967000767 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 1114967000768 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114967000769 S-adenosylmethionine binding site [chemical binding]; other site 1114967000770 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 1114967000771 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1114967000772 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1114967000773 active site 1114967000774 interdomain interaction site; other site 1114967000775 putative metal-binding site [ion binding]; other site 1114967000776 nucleotide binding site [chemical binding]; other site 1114967000777 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1114967000778 domain I; other site 1114967000779 DNA binding groove [nucleotide binding] 1114967000780 phosphate binding site [ion binding]; other site 1114967000781 domain II; other site 1114967000782 domain III; other site 1114967000783 nucleotide binding site [chemical binding]; other site 1114967000784 catalytic site [active] 1114967000785 domain IV; other site 1114967000786 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1114967000787 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1114967000788 thymidylate kinase; Validated; Region: tmk; PRK00698 1114967000789 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1114967000790 TMP-binding site; other site 1114967000791 ATP-binding site [chemical binding]; other site 1114967000792 DNA polymerase III subunit delta'; Validated; Region: PRK07940 1114967000793 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114967000794 Walker A motif; other site 1114967000795 ATP binding site [chemical binding]; other site 1114967000796 Walker B motif; other site 1114967000797 arginine finger; other site 1114967000798 Predicted membrane protein [Function unknown]; Region: COG2259 1114967000799 PSP1 C-terminal conserved region; Region: PSP1; cl00770 1114967000800 TAP-like protein; Region: Abhydrolase_4; pfam08386 1114967000801 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 1114967000802 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 1114967000803 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1114967000804 catalytic core [active] 1114967000805 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 1114967000806 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1114967000807 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1114967000808 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1114967000809 dimer interface [polypeptide binding]; other site 1114967000810 substrate binding site [chemical binding]; other site 1114967000811 metal binding sites [ion binding]; metal-binding site 1114967000812 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 1114967000813 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1114967000814 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 1114967000815 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1114967000816 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1114967000817 Ligand Binding Site [chemical binding]; other site 1114967000818 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1114967000819 active site 1114967000820 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1114967000821 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114967000822 Walker A motif; other site 1114967000823 ATP binding site [chemical binding]; other site 1114967000824 Walker B motif; other site 1114967000825 arginine finger; other site 1114967000826 Peptidase family M41; Region: Peptidase_M41; pfam01434 1114967000827 Protein of unknown function (DUF3729); Region: DUF3729; pfam12526 1114967000828 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1114967000829 homodecamer interface [polypeptide binding]; other site 1114967000830 GTP cyclohydrolase I; Provisional; Region: PLN03044 1114967000831 active site 1114967000832 putative catalytic site residues [active] 1114967000833 zinc binding site [ion binding]; other site 1114967000834 GTP-CH-I/GFRP interaction surface; other site 1114967000835 potential frameshift: common BLAST hit: gi|295129833|ref|YP_003580496.1| OmpA family protein 1114967000836 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1114967000837 dihydropteroate synthase; Region: DHPS; TIGR01496 1114967000838 substrate binding pocket [chemical binding]; other site 1114967000839 dimer interface [polypeptide binding]; other site 1114967000840 inhibitor binding site; inhibition site 1114967000841 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1114967000842 homooctamer interface [polypeptide binding]; other site 1114967000843 active site 1114967000844 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1114967000845 catalytic center binding site [active] 1114967000846 ATP binding site [chemical binding]; other site 1114967000847 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1114967000848 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 1114967000849 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 1114967000850 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 1114967000851 Lsr2; Region: Lsr2; pfam11774 1114967000852 Clp protease ATP binding subunit; Region: clpC; CHL00095 1114967000853 Clp amino terminal domain; Region: Clp_N; pfam02861 1114967000854 Clp amino terminal domain; Region: Clp_N; pfam02861 1114967000855 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114967000856 Walker A motif; other site 1114967000857 ATP binding site [chemical binding]; other site 1114967000858 Walker B motif; other site 1114967000859 arginine finger; other site 1114967000860 UvrB/uvrC motif; Region: UVR; pfam02151 1114967000861 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114967000862 Walker A motif; other site 1114967000863 ATP binding site [chemical binding]; other site 1114967000864 Walker B motif; other site 1114967000865 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1114967000866 Protein of unknown function (DUF2891); Region: DUF2891; pfam11199 1114967000867 Predicted membrane protein [Function unknown]; Region: COG3817 1114967000868 Protein of unknown function (DUF979); Region: DUF979; pfam06166 1114967000869 Protein of unknown function (DUF969); Region: DUF969; pfam06149 1114967000870 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 1114967000871 putative active site [active] 1114967000872 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 1114967000873 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 1114967000874 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 1114967000875 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114967000876 putative substrate translocation pore; other site 1114967000877 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114967000878 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 1114967000879 TIGR01777 family protein; Region: yfcH 1114967000880 putative NAD(P) binding site [chemical binding]; other site 1114967000881 putative active site [active] 1114967000882 Rhomboid family; Region: Rhomboid; pfam01694 1114967000883 hypothetical protein; Provisional; Region: PRK06547 1114967000884 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1114967000885 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114967000886 active site 1114967000887 phosphorylation site [posttranslational modification] 1114967000888 intermolecular recognition site; other site 1114967000889 dimerization interface [polypeptide binding]; other site 1114967000890 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1114967000891 DNA binding residues [nucleotide binding] 1114967000892 dimerization interface [polypeptide binding]; other site 1114967000893 Histidine kinase; Region: HisKA_3; pfam07730 1114967000894 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1114967000895 ATP binding site [chemical binding]; other site 1114967000896 Mg2+ binding site [ion binding]; other site 1114967000897 G-X-G motif; other site 1114967000898 CAT RNA binding domain; Region: CAT_RBD; smart01061 1114967000899 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1114967000900 PRD domain; Region: PRD; pfam00874 1114967000901 PRD domain; Region: PRD; pfam00874 1114967000902 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1114967000903 HPr interaction site; other site 1114967000904 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1114967000905 active site 1114967000906 phosphorylation site [posttranslational modification] 1114967000907 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 1114967000908 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1114967000909 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1114967000910 active site turn [active] 1114967000911 phosphorylation site [posttranslational modification] 1114967000912 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1114967000913 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1114967000914 endonuclease III; Region: ENDO3c; smart00478 1114967000915 minor groove reading motif; other site 1114967000916 helix-hairpin-helix signature motif; other site 1114967000917 active site 1114967000918 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1114967000919 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1114967000920 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1114967000921 inhibitor-cofactor binding pocket; inhibition site 1114967000922 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114967000923 catalytic residue [active] 1114967000924 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1114967000925 dimer interface [polypeptide binding]; other site 1114967000926 active site 1114967000927 Schiff base residues; other site 1114967000928 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 1114967000929 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1114967000930 active site 1114967000931 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1114967000932 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 1114967000933 domain interfaces; other site 1114967000934 active site 1114967000935 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1114967000936 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1114967000937 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1114967000938 substrate binding site [chemical binding]; other site 1114967000939 active site 1114967000940 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1114967000941 Glutamyl-tRNAGlu reductase, N-terminal domain; Region: GlutR_N; pfam05201 1114967000942 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1114967000943 ferrochelatase; Reviewed; Region: hemH; PRK00035 1114967000944 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1114967000945 C-terminal domain interface [polypeptide binding]; other site 1114967000946 active site 1114967000947 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1114967000948 active site 1114967000949 N-terminal domain interface [polypeptide binding]; other site 1114967000950 Chlorite dismutase; Region: Chlor_dismutase; pfam06778 1114967000951 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 1114967000952 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1114967000953 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 1114967000954 DNA repair protein RadA; Provisional; Region: PRK11823 1114967000955 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1114967000956 Walker A motif; other site 1114967000957 ATP binding site [chemical binding]; other site 1114967000958 Walker B motif; other site 1114967000959 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1114967000960 malate dehydrogenase; Provisional; Region: PRK13529 1114967000961 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1114967000962 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1114967000963 NAD(P) binding site [chemical binding]; other site 1114967000964 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 1114967000965 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1114967000966 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1114967000967 AP (apurinic/apyrimidinic) site pocket; other site 1114967000968 DNA interaction; other site 1114967000969 Metal-binding active site; metal-binding site 1114967000970 Proline dehydrogenase; Region: Pro_dh; cl03282 1114967000971 CAAX protease self-immunity; Region: Abi; pfam02517 1114967000972 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1114967000973 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1114967000974 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1114967000975 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1114967000976 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 1114967000977 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 1114967000978 active site 1114967000979 homodimer interface [polypeptide binding]; other site 1114967000980 SAM binding site [chemical binding]; other site 1114967000981 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1114967000982 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1114967000983 active site 1114967000984 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1114967000985 catalytic core [active] 1114967000986 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1114967000987 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1114967000988 catalytic residues [active] 1114967000989 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1114967000990 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1114967000991 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 1114967000992 ResB-like family; Region: ResB; pfam05140 1114967000993 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 1114967000994 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 1114967000995 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1114967000996 Sporulation and spore germination; Region: Germane; pfam10646 1114967000997 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1114967000998 classical (c) SDRs; Region: SDR_c; cd05233 1114967000999 NAD(P) binding site [chemical binding]; other site 1114967001000 active site 1114967001001 mycothione reductase; Reviewed; Region: PRK07846 1114967001002 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1114967001003 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1114967001004 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1114967001005 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1114967001006 intersubunit interface [polypeptide binding]; other site 1114967001007 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1114967001008 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1114967001009 Walker A/P-loop; other site 1114967001010 ATP binding site [chemical binding]; other site 1114967001011 Q-loop/lid; other site 1114967001012 ABC transporter signature motif; other site 1114967001013 Walker B; other site 1114967001014 D-loop; other site 1114967001015 H-loop/switch region; other site 1114967001016 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1114967001017 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1114967001018 ABC-ATPase subunit interface; other site 1114967001019 dimer interface [polypeptide binding]; other site 1114967001020 putative PBP binding regions; other site 1114967001021 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1114967001022 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1114967001023 FAD binding pocket [chemical binding]; other site 1114967001024 FAD binding motif [chemical binding]; other site 1114967001025 phosphate binding motif [ion binding]; other site 1114967001026 NAD binding pocket [chemical binding]; other site 1114967001027 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 1114967001028 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1114967001029 Walker A/P-loop; other site 1114967001030 ATP binding site [chemical binding]; other site 1114967001031 Q-loop/lid; other site 1114967001032 ABC transporter signature motif; other site 1114967001033 Walker B; other site 1114967001034 D-loop; other site 1114967001035 H-loop/switch region; other site 1114967001036 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1114967001037 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114967001038 dimer interface [polypeptide binding]; other site 1114967001039 conserved gate region; other site 1114967001040 putative PBP binding loops; other site 1114967001041 ABC-ATPase subunit interface; other site 1114967001042 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 1114967001043 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114967001044 dimer interface [polypeptide binding]; other site 1114967001045 conserved gate region; other site 1114967001046 putative PBP binding loops; other site 1114967001047 ABC-ATPase subunit interface; other site 1114967001048 PBP superfamily domain; Region: PBP_like_2; cl17296 1114967001049 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1114967001050 active site 1114967001051 Ap6A binding site [chemical binding]; other site 1114967001052 nudix motif; other site 1114967001053 metal binding site [ion binding]; metal-binding site 1114967001054 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1114967001055 catalytic core [active] 1114967001056 polyphosphate kinase; Provisional; Region: PRK05443 1114967001057 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1114967001058 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1114967001059 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 1114967001060 putative domain interface [polypeptide binding]; other site 1114967001061 putative active site [active] 1114967001062 catalytic site [active] 1114967001063 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 1114967001064 putative domain interface [polypeptide binding]; other site 1114967001065 putative active site [active] 1114967001066 catalytic site [active] 1114967001067 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1114967001068 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1114967001069 DNA binding site [nucleotide binding] 1114967001070 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1114967001071 putative active site [active] 1114967001072 dimerization interface [polypeptide binding]; other site 1114967001073 putative tRNAtyr binding site [nucleotide binding]; other site 1114967001074 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 1114967001075 heme-binding site [chemical binding]; other site 1114967001076 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 1114967001077 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1114967001078 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1114967001079 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1114967001080 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1114967001081 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1114967001082 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114967001083 NAD(P) binding site [chemical binding]; other site 1114967001084 active site 1114967001085 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1114967001086 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1114967001087 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1114967001088 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1114967001089 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1114967001090 dimerization domain swap beta strand [polypeptide binding]; other site 1114967001091 regulatory protein interface [polypeptide binding]; other site 1114967001092 active site 1114967001093 regulatory phosphorylation site [posttranslational modification]; other site 1114967001094 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1114967001095 substrate binding site; other site 1114967001096 dimer interface; other site 1114967001097 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cl10030 1114967001098 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829 1114967001099 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 1114967001100 active site 1114967001101 P-loop; other site 1114967001102 phosphorylation site [posttranslational modification] 1114967001103 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 1114967001104 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1114967001105 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114967001106 active site 1114967001107 phosphorylation site [posttranslational modification] 1114967001108 intermolecular recognition site; other site 1114967001109 dimerization interface [polypeptide binding]; other site 1114967001110 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1114967001111 DNA binding site [nucleotide binding] 1114967001112 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1114967001113 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114967001114 dimer interface [polypeptide binding]; other site 1114967001115 phosphorylation site [posttranslational modification] 1114967001116 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114967001117 ATP binding site [chemical binding]; other site 1114967001118 Mg2+ binding site [ion binding]; other site 1114967001119 G-X-G motif; other site 1114967001120 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1114967001121 PhoU domain; Region: PhoU; pfam01895 1114967001122 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1114967001123 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 1114967001124 NodB motif; other site 1114967001125 active site 1114967001126 catalytic site [active] 1114967001127 Zn binding site [ion binding]; other site 1114967001128 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1114967001129 catalytic core [active] 1114967001130 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 1114967001131 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1114967001132 active site 1114967001133 phosphorylation site [posttranslational modification] 1114967001134 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 1114967001135 active site 1114967001136 P-loop; other site 1114967001137 phosphorylation site [posttranslational modification] 1114967001138 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 1114967001139 active site 1114967001140 homodimer interface [polypeptide binding]; other site 1114967001141 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1114967001142 serine hydroxymethyltransferase; Provisional; Region: PRK13580 1114967001143 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1114967001144 dimer interface [polypeptide binding]; other site 1114967001145 active site 1114967001146 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1114967001147 folate binding site [chemical binding]; other site 1114967001148 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1114967001149 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1114967001150 substrate binding site [chemical binding]; other site 1114967001151 ATP binding site [chemical binding]; other site 1114967001152 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 1114967001153 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1114967001154 active site 1114967001155 intersubunit interface [polypeptide binding]; other site 1114967001156 catalytic residue [active] 1114967001157 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1114967001158 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1114967001159 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 1114967001160 substrate binding site [chemical binding]; other site 1114967001161 catalytic residues [active] 1114967001162 Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; cl01752 1114967001163 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1114967001164 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1114967001165 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1114967001166 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1114967001167 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1114967001168 active site 1114967001169 HIGH motif; other site 1114967001170 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1114967001171 KMSKS motif; other site 1114967001172 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1114967001173 tRNA binding surface [nucleotide binding]; other site 1114967001174 anticodon binding site; other site 1114967001175 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 1114967001176 Asp23 family; Region: Asp23; pfam03780 1114967001177 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 1114967001178 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1114967001179 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1114967001180 DNA binding residues [nucleotide binding] 1114967001181 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1114967001182 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1114967001183 Walker A/P-loop; other site 1114967001184 ATP binding site [chemical binding]; other site 1114967001185 Q-loop/lid; other site 1114967001186 ABC transporter signature motif; other site 1114967001187 Walker B; other site 1114967001188 D-loop; other site 1114967001189 H-loop/switch region; other site 1114967001190 TOBE domain; Region: TOBE_2; pfam08402 1114967001191 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1114967001192 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1114967001193 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1114967001194 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1114967001195 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1114967001196 putative DNA binding site [nucleotide binding]; other site 1114967001197 putative Zn2+ binding site [ion binding]; other site 1114967001198 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1114967001199 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1114967001200 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1114967001201 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1114967001202 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1114967001203 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1114967001204 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1114967001205 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114967001206 dimer interface [polypeptide binding]; other site 1114967001207 conserved gate region; other site 1114967001208 putative PBP binding loops; other site 1114967001209 ABC-ATPase subunit interface; other site 1114967001210 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1114967001211 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114967001212 dimer interface [polypeptide binding]; other site 1114967001213 conserved gate region; other site 1114967001214 ABC-ATPase subunit interface; other site 1114967001215 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 1114967001216 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1114967001217 NAD(P) binding site [chemical binding]; other site 1114967001218 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1114967001219 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1114967001220 substrate-cofactor binding pocket; other site 1114967001221 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114967001222 catalytic residue [active] 1114967001223 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1114967001224 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 1114967001225 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1114967001226 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1114967001227 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114967001228 Walker A/P-loop; other site 1114967001229 ATP binding site [chemical binding]; other site 1114967001230 Q-loop/lid; other site 1114967001231 ABC transporter signature motif; other site 1114967001232 Walker B; other site 1114967001233 D-loop; other site 1114967001234 H-loop/switch region; other site 1114967001235 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1114967001236 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1114967001237 Protein of unknown function, DUF488; Region: DUF488; cl01246 1114967001238 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 1114967001239 putative ADP-ribose binding site [chemical binding]; other site 1114967001240 putative active site [active] 1114967001241 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1114967001242 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1114967001243 NAD(P) binding site [chemical binding]; other site 1114967001244 substrate binding site [chemical binding]; other site 1114967001245 dimer interface [polypeptide binding]; other site 1114967001246 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1114967001247 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1114967001248 Walker A/P-loop; other site 1114967001249 ATP binding site [chemical binding]; other site 1114967001250 Q-loop/lid; other site 1114967001251 ABC transporter signature motif; other site 1114967001252 Walker B; other site 1114967001253 D-loop; other site 1114967001254 H-loop/switch region; other site 1114967001255 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1114967001256 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1114967001257 Histidine kinase; Region: HisKA_3; pfam07730 1114967001258 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1114967001259 ATP binding site [chemical binding]; other site 1114967001260 Mg2+ binding site [ion binding]; other site 1114967001261 G-X-G motif; other site 1114967001262 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1114967001263 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114967001264 active site 1114967001265 phosphorylation site [posttranslational modification] 1114967001266 intermolecular recognition site; other site 1114967001267 dimerization interface [polypeptide binding]; other site 1114967001268 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1114967001269 DNA binding residues [nucleotide binding] 1114967001270 dimerization interface [polypeptide binding]; other site 1114967001271 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1114967001272 catalytic core [active] 1114967001273 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 1114967001274 cobyric acid synthase; Provisional; Region: PRK00784 1114967001275 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1114967001276 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1114967001277 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1114967001278 catalytic triad [active] 1114967001279 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 1114967001280 active site 1114967001281 SAM binding site [chemical binding]; other site 1114967001282 homodimer interface [polypeptide binding]; other site 1114967001283 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 1114967001284 active site 1114967001285 SAM binding site [chemical binding]; other site 1114967001286 homodimer interface [polypeptide binding]; other site 1114967001287 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 1114967001288 putative homodimer interface [polypeptide binding]; other site 1114967001289 active site 1114967001290 SAM binding site [chemical binding]; other site 1114967001291 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 1114967001292 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 1114967001293 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 1114967001294 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 1114967001295 active site 1114967001296 SAM binding site [chemical binding]; other site 1114967001297 homodimer interface [polypeptide binding]; other site 1114967001298 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1114967001299 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1114967001300 putative active site [active] 1114967001301 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 1114967001302 putative active site [active] 1114967001303 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 1114967001304 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1114967001305 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1114967001306 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1114967001307 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1114967001308 putative PBP binding regions; other site 1114967001309 ABC-ATPase subunit interface; other site 1114967001310 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1114967001311 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1114967001312 Walker A/P-loop; other site 1114967001313 ATP binding site [chemical binding]; other site 1114967001314 Q-loop/lid; other site 1114967001315 ABC transporter signature motif; other site 1114967001316 Walker B; other site 1114967001317 D-loop; other site 1114967001318 H-loop/switch region; other site 1114967001319 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1114967001320 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 1114967001321 intersubunit interface [polypeptide binding]; other site 1114967001322 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 1114967001323 AAA domain; Region: AAA_14; pfam13173 1114967001324 Nuclease-related domain; Region: NERD; pfam08378 1114967001325 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 1114967001326 Precorrin-8X methylmutase; Region: CbiC; pfam02570 1114967001327 cobalt transport protein CbiM; Validated; Region: PRK08319 1114967001328 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 1114967001329 cobalt transport protein CbiN; Provisional; Region: PRK02898 1114967001330 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 1114967001331 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1114967001332 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 1114967001333 Walker A/P-loop; other site 1114967001334 ATP binding site [chemical binding]; other site 1114967001335 Q-loop/lid; other site 1114967001336 ABC transporter signature motif; other site 1114967001337 Walker B; other site 1114967001338 D-loop; other site 1114967001339 H-loop/switch region; other site 1114967001340 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 1114967001341 Methyltransferase domain; Region: Methyltransf_18; pfam12847 1114967001342 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 1114967001343 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 1114967001344 homodimer interface [polypeptide binding]; other site 1114967001345 Walker A motif; other site 1114967001346 ATP binding site [chemical binding]; other site 1114967001347 hydroxycobalamin binding site [chemical binding]; other site 1114967001348 Walker B motif; other site 1114967001349 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1114967001350 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 1114967001351 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 1114967001352 catalytic triad [active] 1114967001353 hypothetical protein; Provisional; Region: PRK07908 1114967001354 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1114967001355 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114967001356 homodimer interface [polypeptide binding]; other site 1114967001357 catalytic residue [active] 1114967001358 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1114967001359 homodimer interface [polypeptide binding]; other site 1114967001360 active site 1114967001361 SAM binding site [chemical binding]; other site 1114967001362 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 1114967001363 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 1114967001364 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 1114967001365 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1114967001366 putative dimer interface [polypeptide binding]; other site 1114967001367 active site pocket [active] 1114967001368 putative cataytic base [active] 1114967001369 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 1114967001370 homotrimer interface [polypeptide binding]; other site 1114967001371 Walker A motif; other site 1114967001372 GTP binding site [chemical binding]; other site 1114967001373 Walker B motif; other site 1114967001374 cobalamin synthase; Reviewed; Region: cobS; PRK00235 1114967001375 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1114967001376 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1114967001377 intersubunit interface [polypeptide binding]; other site 1114967001378 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 1114967001379 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1114967001380 active site 1114967001381 phosphorylation site [posttranslational modification] 1114967001382 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 1114967001383 active site 1114967001384 P-loop; other site 1114967001385 phosphorylation site [posttranslational modification] 1114967001386 S-Ribosylhomocysteinase (LuxS); Region: LuxS; cl00802 1114967001387 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1114967001388 S-ribosylhomocysteinase; Provisional; Region: PRK02260 1114967001389 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 1114967001390 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1114967001391 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1114967001392 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 1114967001393 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1114967001394 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1114967001395 ring oligomerisation interface [polypeptide binding]; other site 1114967001396 ATP/Mg binding site [chemical binding]; other site 1114967001397 stacking interactions; other site 1114967001398 hinge regions; other site 1114967001399 Transaldolase; Region: Transaldolase; pfam00923 1114967001400 catalytic residue [active] 1114967001401 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1114967001402 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114967001403 DNA-binding site [nucleotide binding]; DNA binding site 1114967001404 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1114967001405 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1114967001406 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1114967001407 substrate binding site [chemical binding]; other site 1114967001408 ATP binding site [chemical binding]; other site 1114967001409 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 1114967001410 KduI/IolB family; Region: KduI; pfam04962 1114967001411 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 1114967001412 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1114967001413 PYR/PP interface [polypeptide binding]; other site 1114967001414 dimer interface [polypeptide binding]; other site 1114967001415 TPP binding site [chemical binding]; other site 1114967001416 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cd00368 1114967001417 molybdopterin cofactor binding site; other site 1114967001418 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 1114967001419 TPP-binding site; other site 1114967001420 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1114967001421 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1114967001422 tetrameric interface [polypeptide binding]; other site 1114967001423 NAD binding site [chemical binding]; other site 1114967001424 catalytic residues [active] 1114967001425 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1114967001426 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1114967001427 DNA binding site [nucleotide binding] 1114967001428 domain linker motif; other site 1114967001429 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1114967001430 dimerization interface [polypeptide binding]; other site 1114967001431 ligand binding site [chemical binding]; other site 1114967001432 potential frameshift: common BLAST hit: gi|295130020|ref|YP_003580683.1| oxidoreductase, NAD-binding domain protein 1114967001433 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1114967001434 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1114967001435 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1114967001436 AP (apurinic/apyrimidinic) site pocket; other site 1114967001437 DNA interaction; other site 1114967001438 Metal-binding active site; metal-binding site 1114967001439 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1114967001440 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1114967001441 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1114967001442 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 1114967001443 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114967001444 putative substrate translocation pore; other site 1114967001445 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114967001446 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1114967001447 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1114967001448 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1114967001449 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1114967001450 DNA interaction; other site 1114967001451 Metal-binding active site; metal-binding site 1114967001452 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1114967001453 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1114967001454 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1114967001455 CAAX protease self-immunity; Region: Abi; pfam02517 1114967001456 CutC family; Region: CutC; cl01218 1114967001457 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1114967001458 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1114967001459 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1114967001460 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1114967001461 ATP binding site [chemical binding]; other site 1114967001462 putative Mg++ binding site [ion binding]; other site 1114967001463 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1114967001464 nucleotide binding region [chemical binding]; other site 1114967001465 ATP-binding site [chemical binding]; other site 1114967001466 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1114967001467 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1114967001468 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1114967001469 active site 1114967001470 trimer interface [polypeptide binding]; other site 1114967001471 allosteric site; other site 1114967001472 active site lid [active] 1114967001473 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1114967001474 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1114967001475 DNA-binding site [nucleotide binding]; DNA binding site 1114967001476 RNA-binding motif; other site 1114967001477 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 1114967001478 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1114967001479 phosphoserine aminotransferase; Provisional; Region: PRK03080 1114967001480 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1114967001481 catalytic residue [active] 1114967001482 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1114967001483 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1114967001484 active site 1114967001485 dimer interface [polypeptide binding]; other site 1114967001486 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1114967001487 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 1114967001488 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1114967001489 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1114967001490 catalytic residues [active] 1114967001491 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1114967001492 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114967001493 putative substrate translocation pore; other site 1114967001494 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114967001495 Eukaryotic UGPase catalyses the synthesis of UDP-Glucose; Region: UGPase_euk; cd00897 1114967001496 active site 1114967001497 substrate binding site; other site 1114967001498 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 1114967001499 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1114967001500 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1114967001501 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 1114967001502 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1114967001503 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 1114967001504 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1114967001505 dimer interface [polypeptide binding]; other site 1114967001506 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1114967001507 putative MPT binding site; other site 1114967001508 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1114967001509 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1114967001510 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 1114967001511 MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor...; Region: MoaC; cl00242 1114967001512 trimer interface [polypeptide binding]; other site 1114967001513 dimer interface [polypeptide binding]; other site 1114967001514 putative active site [active] 1114967001515 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1114967001516 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1114967001517 dimer interface [polypeptide binding]; other site 1114967001518 putative functional site; other site 1114967001519 putative MPT binding site; other site 1114967001520 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1114967001521 MoaE homodimer interface [polypeptide binding]; other site 1114967001522 MoaD interaction [polypeptide binding]; other site 1114967001523 active site residues [active] 1114967001524 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1114967001525 MoaE interaction surface [polypeptide binding]; other site 1114967001526 MoeB interaction surface [polypeptide binding]; other site 1114967001527 thiocarboxylated glycine; other site 1114967001528 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1114967001529 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1114967001530 FeS/SAM binding site; other site 1114967001531 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1114967001532 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 1114967001533 DNA binding residues [nucleotide binding] 1114967001534 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 1114967001535 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1114967001536 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1114967001537 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1114967001538 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114967001539 dimer interface [polypeptide binding]; other site 1114967001540 conserved gate region; other site 1114967001541 putative PBP binding loops; other site 1114967001542 ABC-ATPase subunit interface; other site 1114967001543 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 1114967001544 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114967001545 Walker A/P-loop; other site 1114967001546 ATP binding site [chemical binding]; other site 1114967001547 Q-loop/lid; other site 1114967001548 ABC transporter signature motif; other site 1114967001549 Walker B; other site 1114967001550 D-loop; other site 1114967001551 H-loop/switch region; other site 1114967001552 Predicted transcriptional regulator [Transcription]; Region: COG2345 1114967001553 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 1114967001554 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 1114967001555 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 1114967001556 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1114967001557 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 1114967001558 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1114967001559 [4Fe-4S] binding site [ion binding]; other site 1114967001560 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1114967001561 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1114967001562 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1114967001563 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1114967001564 molybdopterin cofactor binding site; other site 1114967001565 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1114967001566 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114967001567 putative substrate translocation pore; other site 1114967001568 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1114967001569 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1114967001570 GTP binding site; other site 1114967001571 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1114967001572 MPT binding site; other site 1114967001573 trimer interface [polypeptide binding]; other site 1114967001574 DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519 1114967001575 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 1114967001576 4Fe-4S binding domain; Region: Fer4; pfam00037 1114967001577 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 1114967001578 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 1114967001579 putative [Fe4-S4] binding site [ion binding]; other site 1114967001580 putative molybdopterin cofactor binding site [chemical binding]; other site 1114967001581 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 1114967001582 putative molybdopterin cofactor binding site; other site 1114967001583 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 1114967001584 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1114967001585 ATP binding site [chemical binding]; other site 1114967001586 substrate interface [chemical binding]; other site 1114967001587 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1114967001588 ThiS interaction site; other site 1114967001589 putative active site [active] 1114967001590 tetramer interface [polypeptide binding]; other site 1114967001591 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1114967001592 thiS-thiF/thiG interaction site; other site 1114967001593 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1114967001594 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1114967001595 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 1114967001596 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 1114967001597 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 1114967001598 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1114967001599 Predicted methyltransferases [General function prediction only]; Region: COG0313 1114967001600 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1114967001601 putative SAM binding site [chemical binding]; other site 1114967001602 putative homodimer interface [polypeptide binding]; other site 1114967001603 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1114967001604 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1114967001605 active site 1114967001606 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1114967001607 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 1114967001608 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 1114967001609 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1114967001610 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1114967001611 MarR family; Region: MarR_2; cl17246 1114967001612 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114967001613 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1114967001614 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14360 1114967001615 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1114967001616 Substrate binding site; other site 1114967001617 Mg++ binding site; other site 1114967001618 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1114967001619 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1114967001620 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 1114967001621 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1114967001622 active site 1114967001623 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1114967001624 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1114967001625 5S rRNA interface [nucleotide binding]; other site 1114967001626 CTC domain interface [polypeptide binding]; other site 1114967001627 L16 interface [polypeptide binding]; other site 1114967001628 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1114967001629 putative active site [active] 1114967001630 catalytic residue [active] 1114967001631 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1114967001632 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1114967001633 NAD binding site [chemical binding]; other site 1114967001634 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1114967001635 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH6; cd08260 1114967001636 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1114967001637 putative NAD(P) binding site [chemical binding]; other site 1114967001638 catalytic Zn binding site [ion binding]; other site 1114967001639 structural Zn binding site [ion binding]; other site 1114967001640 Protease prsW family; Region: PrsW-protease; pfam13367 1114967001641 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1114967001642 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1114967001643 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1114967001644 ATP binding site [chemical binding]; other site 1114967001645 putative Mg++ binding site [ion binding]; other site 1114967001646 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1114967001647 nucleotide binding region [chemical binding]; other site 1114967001648 ATP-binding site [chemical binding]; other site 1114967001649 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1114967001650 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1114967001651 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12333 1114967001652 homodimer interface [polypeptide binding]; other site 1114967001653 metal binding site [ion binding]; metal-binding site 1114967001654 enolase; Provisional; Region: eno; PRK00077 1114967001655 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1114967001656 dimer interface [polypeptide binding]; other site 1114967001657 metal binding site [ion binding]; metal-binding site 1114967001658 substrate binding pocket [chemical binding]; other site 1114967001659 Septum formation initiator; Region: DivIC; pfam04977 1114967001660 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1114967001661 Protein of unknown function (DUF501); Region: DUF501; pfam04417 1114967001662 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1114967001663 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1114967001664 Bax inhibitor 1 like; Region: BaxI_1; cl17691 1114967001665 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 1114967001666 nudix motif; other site 1114967001667 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114967001668 Coenzyme A binding pocket [chemical binding]; other site 1114967001669 Predicted membrane protein [Function unknown]; Region: COG2246 1114967001670 GtrA-like protein; Region: GtrA; pfam04138 1114967001671 Predicted membrane protein [Function unknown]; Region: COG1297 1114967001672 putative oligopeptide transporter, OPT family; Region: TIGR00733 1114967001673 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1114967001674 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1114967001675 active site 1114967001676 catalytic tetrad [active] 1114967001677 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 1114967001678 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 1114967001679 Na2 binding site [ion binding]; other site 1114967001680 putative substrate binding site 1 [chemical binding]; other site 1114967001681 Na binding site 1 [ion binding]; other site 1114967001682 putative substrate binding site 2 [chemical binding]; other site 1114967001683 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1114967001684 ligand binding site [chemical binding]; other site 1114967001685 active site 1114967001686 UGI interface [polypeptide binding]; other site 1114967001687 catalytic site [active] 1114967001688 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1114967001689 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1114967001690 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1114967001691 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1114967001692 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1114967001693 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 1114967001694 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 1114967001695 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 1114967001696 catalytic residues [active] 1114967001697 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 1114967001698 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 1114967001699 catalytic residue [active] 1114967001700 putative FPP diphosphate binding site; other site 1114967001701 putative FPP binding hydrophobic cleft; other site 1114967001702 dimer interface [polypeptide binding]; other site 1114967001703 putative IPP diphosphate binding site; other site 1114967001704 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1114967001705 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1114967001706 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 1114967001707 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 1114967001708 putative active site [active] 1114967001709 PhoH-like protein; Region: PhoH; pfam02562 1114967001710 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 1114967001711 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1114967001712 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1114967001713 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1114967001714 generic binding surface II; other site 1114967001715 generic binding surface I; other site 1114967001716 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 1114967001717 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1114967001718 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1114967001719 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1114967001720 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1114967001721 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1114967001722 RmuC family; Region: RmuC; pfam02646 1114967001723 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 1114967001724 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 1114967001725 active site 1114967001726 metal binding site [ion binding]; metal-binding site 1114967001727 GTP-binding protein YchF; Reviewed; Region: PRK09601 1114967001728 YchF GTPase; Region: YchF; cd01900 1114967001729 G1 box; other site 1114967001730 GTP/Mg2+ binding site [chemical binding]; other site 1114967001731 Switch I region; other site 1114967001732 G2 box; other site 1114967001733 Switch II region; other site 1114967001734 G3 box; other site 1114967001735 G4 box; other site 1114967001736 G5 box; other site 1114967001737 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1114967001738 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114967001739 putative substrate translocation pore; other site 1114967001740 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114967001741 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1114967001742 MarR family; Region: MarR; pfam01047 1114967001743 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1114967001744 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 1114967001745 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1114967001746 potential catalytic triad [active] 1114967001747 conserved cys residue [active] 1114967001748 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 1114967001749 Spore germination protein; Region: Spore_permease; cl17796 1114967001750 arginine deiminase; Provisional; Region: PRK01388 1114967001751 ornithine carbamoyltransferase; Validated; Region: PRK02102 1114967001752 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1114967001753 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1114967001754 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 1114967001755 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1114967001756 putative substrate binding site [chemical binding]; other site 1114967001757 nucleotide binding site [chemical binding]; other site 1114967001758 nucleotide binding site [chemical binding]; other site 1114967001759 homodimer interface [polypeptide binding]; other site 1114967001760 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1114967001761 Peptidyl-tRNA hydrolase, type 2 (PTH2)_like . Peptidyl-tRNA hydrolase activity releases tRNA from the premature translation termination product peptidyl-tRNA. Two structurally different enzymes have been reported to encode such activity, Pth present in...; Region: PTH2_family; cl00869 1114967001762 dimer interface [polypeptide binding]; other site 1114967001763 putative active site [active] 1114967001764 ACT domain; Region: ACT_6; pfam13740 1114967001765 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 1114967001766 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869 1114967001767 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1114967001768 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1114967001769 active site 1114967001770 catalytic tetrad [active] 1114967001771 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1114967001772 dimer interface [polypeptide binding]; other site 1114967001773 catalytic triad [active] 1114967001774 peroxidatic and resolving cysteines [active] 1114967001775 lysine transporter; Provisional; Region: PRK10836 1114967001776 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like; cd11354 1114967001777 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1114967001778 active site 1114967001779 catalytic site [active] 1114967001780 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 1114967001781 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1114967001782 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1114967001783 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1114967001784 potential frameshift: common BLAST hit: gi|50842080|ref|YP_055307.1| lysophospholipase 1114967001785 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 1114967001786 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 1114967001787 heterodimer interface [polypeptide binding]; other site 1114967001788 substrate interaction site [chemical binding]; other site 1114967001789 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 1114967001790 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 1114967001791 active site 1114967001792 substrate binding site [chemical binding]; other site 1114967001793 coenzyme B12 binding site [chemical binding]; other site 1114967001794 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 1114967001795 B12 binding site [chemical binding]; other site 1114967001796 cobalt ligand [ion binding]; other site 1114967001797 membrane ATPase/protein kinase; Provisional; Region: PRK09435 1114967001798 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 1114967001799 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 1114967001800 Walker A; other site 1114967001801 G1 box; other site 1114967001802 GTP/Mg2+ binding site [chemical binding]; other site 1114967001803 Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496 1114967001804 active site 1114967001805 catalytic triad [active] 1114967001806 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1114967001807 RNA binding surface [nucleotide binding]; other site 1114967001808 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1114967001809 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1114967001810 Walker A/P-loop; other site 1114967001811 ATP binding site [chemical binding]; other site 1114967001812 Q-loop/lid; other site 1114967001813 ABC transporter signature motif; other site 1114967001814 Walker B; other site 1114967001815 D-loop; other site 1114967001816 H-loop/switch region; other site 1114967001817 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114967001818 dimer interface [polypeptide binding]; other site 1114967001819 ABC-ATPase subunit interface; other site 1114967001820 putative PBP binding loops; other site 1114967001821 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1114967001822 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1114967001823 DNA binding site [nucleotide binding] 1114967001824 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 1114967001825 ligand binding site [chemical binding]; other site 1114967001826 dimerization interface (open form) [polypeptide binding]; other site 1114967001827 dimerization interface (closed form) [polypeptide binding]; other site 1114967001828 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1114967001829 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1114967001830 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 1114967001831 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 1114967001832 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1114967001833 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114967001834 dimer interface [polypeptide binding]; other site 1114967001835 conserved gate region; other site 1114967001836 putative PBP binding loops; other site 1114967001837 ABC-ATPase subunit interface; other site 1114967001838 Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812 1114967001839 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 1114967001840 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 1114967001841 trimer interface [polypeptide binding]; other site 1114967001842 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1114967001843 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 1114967001844 substrate binding site [chemical binding]; other site 1114967001845 Mn binding site [ion binding]; other site 1114967001846 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 1114967001847 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1114967001848 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1114967001849 Walker A/P-loop; other site 1114967001850 ATP binding site [chemical binding]; other site 1114967001851 Q-loop/lid; other site 1114967001852 ABC transporter signature motif; other site 1114967001853 Walker B; other site 1114967001854 D-loop; other site 1114967001855 H-loop/switch region; other site 1114967001856 potential frameshift: common BLAST hit: gi|50842100|ref|YP_055327.1| permease 1114967001857 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1114967001858 dimer interface [polypeptide binding]; other site 1114967001859 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1114967001860 putative PBP binding regions; other site 1114967001861 ABC-ATPase subunit interface; other site 1114967001862 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1114967001863 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1114967001864 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1114967001865 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1114967001866 intersubunit interface [polypeptide binding]; other site 1114967001867 Isochorismatase family; Region: Isochorismatase; pfam00857 1114967001868 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1114967001869 catalytic triad [active] 1114967001870 conserved cis-peptide bond; other site 1114967001871 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1114967001872 Na binding site [ion binding]; other site 1114967001873 Proline dehydrogenase; Region: Pro_dh; cl03282 1114967001874 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 1114967001875 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1114967001876 Glutamate binding site [chemical binding]; other site 1114967001877 NAD binding site [chemical binding]; other site 1114967001878 catalytic residues [active] 1114967001879 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1114967001880 L-iditol 2-dehydrogenase; Region: iditol_2_DH_like; cd08235 1114967001881 putative NAD(P) binding site [chemical binding]; other site 1114967001882 catalytic Zn binding site [ion binding]; other site 1114967001883 dihydroxyacetone kinase; Provisional; Region: PRK14479 1114967001884 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 1114967001885 DAK2 domain; Region: Dak2; pfam02734 1114967001886 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 1114967001887 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1114967001888 active site 1114967001889 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1114967001890 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114967001891 Coenzyme A binding pocket [chemical binding]; other site 1114967001892 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1114967001893 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 1114967001894 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 1114967001895 ligand binding site [chemical binding]; other site 1114967001896 homodimer interface [polypeptide binding]; other site 1114967001897 NAD(P) binding site [chemical binding]; other site 1114967001898 trimer interface B [polypeptide binding]; other site 1114967001899 trimer interface A [polypeptide binding]; other site 1114967001900 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 1114967001901 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 1114967001902 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 1114967001903 Ferredoxin [Energy production and conversion]; Region: COG1146 1114967001904 4Fe-4S binding domain; Region: Fer4; pfam00037 1114967001905 succinyldiaminopimelate transaminase; Region: DapC_actino; TIGR03539 1114967001906 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1114967001907 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114967001908 homodimer interface [polypeptide binding]; other site 1114967001909 catalytic residue [active] 1114967001910 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 1114967001911 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 1114967001912 putative trimer interface [polypeptide binding]; other site 1114967001913 putative CoA binding site [chemical binding]; other site 1114967001914 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 1114967001915 Amidinotransferase; Region: Amidinotransf; cl12043 1114967001916 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1114967001917 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114967001918 metabolite-proton symporter; Region: 2A0106; TIGR00883 1114967001919 putative substrate translocation pore; other site 1114967001920 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 1114967001921 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 1114967001922 metal binding site [ion binding]; metal-binding site 1114967001923 putative dimer interface [polypeptide binding]; other site 1114967001924 DivIVA domain; Region: DivI1A_domain; TIGR03544 1114967001925 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 1114967001926 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 1114967001927 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1114967001928 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 1114967001929 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1114967001930 ligand binding site; other site 1114967001931 oligomer interface; other site 1114967001932 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1114967001933 dimer interface [polypeptide binding]; other site 1114967001934 N-terminal domain interface [polypeptide binding]; other site 1114967001935 sulfate 1 binding site; other site 1114967001936 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1114967001937 S-adenosylmethionine binding site [chemical binding]; other site 1114967001938 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1114967001939 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1114967001940 dimer interface [polypeptide binding]; other site 1114967001941 active site 1114967001942 catalytic residue [active] 1114967001943 sec-independent translocase; Provisional; Region: PRK01371 1114967001944 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 1114967001945 Domain of unknown function DUF59; Region: DUF59; pfam01883 1114967001946 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1114967001947 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1114967001948 Walker A motif; other site 1114967001949 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 1114967001950 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1114967001951 MgtE intracellular N domain; Region: MgtE_N; smart00924 1114967001952 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1114967001953 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1114967001954 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 1114967001955 proline aminopeptidase P II; Provisional; Region: PRK10879 1114967001956 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1114967001957 active site 1114967001958 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 1114967001959 Putative zinc ribbon domain; Region: DUF164; pfam02591 1114967001960 YcfA-like protein; Region: YcfA; cl00752 1114967001961 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 1114967001962 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1114967001963 intersubunit interface [polypeptide binding]; other site 1114967001964 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1114967001965 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1114967001966 ABC-ATPase subunit interface; other site 1114967001967 dimer interface [polypeptide binding]; other site 1114967001968 putative PBP binding regions; other site 1114967001969 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1114967001970 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 1114967001971 Walker A/P-loop; other site 1114967001972 ATP binding site [chemical binding]; other site 1114967001973 Q-loop/lid; other site 1114967001974 ABC transporter signature motif; other site 1114967001975 Walker B; other site 1114967001976 D-loop; other site 1114967001977 H-loop/switch region; other site 1114967001978 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 1114967001979 dimer interface [polypeptide binding]; other site 1114967001980 [2Fe-2S] cluster binding site [ion binding]; other site 1114967001981 Protein of unknown function (DUF466); Region: DUF466; cl01082 1114967001982 potential frameshift: common BLAST hit: gi|50842147|ref|YP_055374.1| carbon starvation protein A 1114967001983 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 1114967001984 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1114967001985 active site 1114967001986 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 1114967001987 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1114967001988 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1114967001989 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1114967001990 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 1114967001991 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1114967001992 metal binding triad; other site 1114967001993 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1114967001994 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1114967001995 metal binding triad; other site 1114967001996 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1114967001997 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1114967001998 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 1114967001999 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1114967002000 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1114967002001 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1114967002002 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1114967002003 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1114967002004 putative active site [active] 1114967002005 glutamine synthetase, type I; Region: GlnA; TIGR00653 1114967002006 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1114967002007 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1114967002008 RDD family; Region: RDD; pfam06271 1114967002009 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1114967002010 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 1114967002011 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1114967002012 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1114967002013 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1114967002014 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 1114967002015 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1114967002016 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114967002017 DNA-binding site [nucleotide binding]; DNA binding site 1114967002018 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1114967002019 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1114967002020 active site turn [active] 1114967002021 phosphorylation site [posttranslational modification] 1114967002022 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1114967002023 active site turn [active] 1114967002024 phosphorylation site [posttranslational modification] 1114967002025 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1114967002026 HPr interaction site; other site 1114967002027 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1114967002028 active site 1114967002029 phosphorylation site [posttranslational modification] 1114967002030 Protein of unknown function (DUF1440); Region: DUF1440; pfam07274 1114967002031 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 1114967002032 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1114967002033 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1114967002034 ABC transporter; Region: ABC_tran_2; pfam12848 1114967002035 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1114967002036 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 1114967002037 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 1114967002038 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 1114967002039 Asp-box motif; other site 1114967002040 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1114967002041 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 1114967002042 Asp-box motif; other site 1114967002043 catalytic site [active] 1114967002044 putative sialic acid transporter; Provisional; Region: PRK03893 1114967002045 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114967002046 putative substrate translocation pore; other site 1114967002047 CAMP factor (Cfa); Region: CAMP_factor; pfam07373 1114967002048 lipoyl synthase; Provisional; Region: PRK05481 1114967002049 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1114967002050 FeS/SAM binding site; other site 1114967002051 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1114967002052 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1114967002053 metal-binding site [ion binding] 1114967002054 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1114967002055 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114967002056 motif II; other site 1114967002057 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 1114967002058 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1114967002059 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase; Region: SucB_Actino; TIGR02927 1114967002060 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1114967002061 E3 interaction surface; other site 1114967002062 lipoyl attachment site [posttranslational modification]; other site 1114967002063 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1114967002064 E3 interaction surface; other site 1114967002065 lipoyl attachment site [posttranslational modification]; other site 1114967002066 e3 binding domain; Region: E3_binding; pfam02817 1114967002067 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1114967002068 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1114967002069 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1114967002070 interface (dimer of trimers) [polypeptide binding]; other site 1114967002071 Substrate-binding/catalytic site; other site 1114967002072 Zn-binding sites [ion binding]; other site 1114967002073 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 1114967002074 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1114967002075 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 1114967002076 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 1114967002077 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1114967002078 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1114967002079 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1114967002080 D-pathway; other site 1114967002081 Putative ubiquinol binding site [chemical binding]; other site 1114967002082 Low-spin heme (heme b) binding site [chemical binding]; other site 1114967002083 Putative water exit pathway; other site 1114967002084 Binuclear center (heme o3/CuB) [ion binding]; other site 1114967002085 K-pathway; other site 1114967002086 Putative proton exit pathway; other site 1114967002087 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 1114967002088 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1114967002089 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1114967002090 Walker A/P-loop; other site 1114967002091 ATP binding site [chemical binding]; other site 1114967002092 Q-loop/lid; other site 1114967002093 ABC transporter signature motif; other site 1114967002094 Walker B; other site 1114967002095 D-loop; other site 1114967002096 H-loop/switch region; other site 1114967002097 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1114967002098 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1114967002099 NAD(P) binding site [chemical binding]; other site 1114967002100 putative active site [active] 1114967002101 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 1114967002102 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1114967002103 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1114967002104 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1114967002105 phosphate binding site [ion binding]; other site 1114967002106 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1114967002107 active site 1114967002108 DNA binding site [nucleotide binding] 1114967002109 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1114967002110 heme bH binding site [chemical binding]; other site 1114967002111 intrachain domain interface; other site 1114967002112 heme bL binding site [chemical binding]; other site 1114967002113 interchain domain interface [polypeptide binding]; other site 1114967002114 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 1114967002115 Qo binding site; other site 1114967002116 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1114967002117 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1114967002118 iron-sulfur cluster [ion binding]; other site 1114967002119 [2Fe-2S] cluster binding site [ion binding]; other site 1114967002120 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1114967002121 Cytochrome c; Region: Cytochrom_C; pfam00034 1114967002122 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1114967002123 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1114967002124 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 1114967002125 Subunit I/III interface [polypeptide binding]; other site 1114967002126 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1114967002127 active site 1114967002128 phosphorylation site [posttranslational modification] 1114967002129 intermolecular recognition site; other site 1114967002130 dimerization interface [polypeptide binding]; other site 1114967002131 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1114967002132 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304 1114967002133 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 1114967002134 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1114967002135 active site 1114967002136 Rhomboid family; Region: Rhomboid; cl11446 1114967002137 hypothetical protein; Validated; Region: PRK07883 1114967002138 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1114967002139 active site 1114967002140 catalytic site [active] 1114967002141 substrate binding site [chemical binding]; other site 1114967002142 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1114967002143 GIY-YIG motif/motif A; other site 1114967002144 active site 1114967002145 catalytic site [active] 1114967002146 putative DNA binding site [nucleotide binding]; other site 1114967002147 metal binding site [ion binding]; metal-binding site 1114967002148 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1114967002149 NlpC/P60 family; Region: NLPC_P60; pfam00877 1114967002150 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 1114967002151 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1114967002152 nucleotide binding site [chemical binding]; other site 1114967002153 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1114967002154 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1114967002155 putative acyl-acceptor binding pocket; other site 1114967002156 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 1114967002157 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 1114967002158 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 1114967002159 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1114967002160 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1114967002161 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1114967002162 EamA-like transporter family; Region: EamA; pfam00892 1114967002163 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1114967002164 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1114967002165 active site 1114967002166 ATP binding site [chemical binding]; other site 1114967002167 substrate binding site [chemical binding]; other site 1114967002168 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1114967002169 substrate binding site [chemical binding]; other site 1114967002170 activation loop (A-loop); other site 1114967002171 activation loop (A-loop); other site 1114967002172 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607 1114967002173 active site 1114967002174 barstar interaction site; other site 1114967002175 Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141 1114967002176 putative RNAase interaction site [polypeptide binding]; other site 1114967002177 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1114967002178 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1114967002179 substrate binding pocket [chemical binding]; other site 1114967002180 chain length determination region; other site 1114967002181 substrate-Mg2+ binding site; other site 1114967002182 catalytic residues [active] 1114967002183 aspartate-rich region 1; other site 1114967002184 active site lid residues [active] 1114967002185 aspartate-rich region 2; other site 1114967002186 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246 1114967002187 Part of AAA domain; Region: AAA_19; pfam13245 1114967002188 Family description; Region: UvrD_C_2; pfam13538 1114967002189 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1114967002190 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1114967002191 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1114967002192 putative dimer interface [polypeptide binding]; other site 1114967002193 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1114967002194 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1114967002195 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114967002196 DNA-binding site [nucleotide binding]; DNA binding site 1114967002197 FCD domain; Region: FCD; pfam07729 1114967002198 glycine dehydrogenase; Provisional; Region: PRK05367 1114967002199 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1114967002200 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1114967002201 catalytic residue [active] 1114967002202 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1114967002203 tetramer interface [polypeptide binding]; other site 1114967002204 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114967002205 catalytic residue [active] 1114967002206 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1114967002207 lipoyl attachment site [posttranslational modification]; other site 1114967002208 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1114967002209 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 1114967002210 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1114967002211 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1114967002212 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1114967002213 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1114967002214 Protein of unknown function DUF58; Region: DUF58; pfam01882 1114967002215 MoxR-like ATPases [General function prediction only]; Region: COG0714 1114967002216 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114967002217 ATP binding site [chemical binding]; other site 1114967002218 Walker A motif; other site 1114967002219 Walker B motif; other site 1114967002220 arginine finger; other site 1114967002221 cell division protein MraZ; Reviewed; Region: PRK00326 1114967002222 MraZ protein; Region: MraZ; pfam02381 1114967002223 MraZ protein; Region: MraZ; pfam02381 1114967002224 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1114967002225 MraW methylase family; Region: Methyltransf_5; cl17771 1114967002226 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1114967002227 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 1114967002228 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1114967002229 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1114967002230 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1114967002231 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1114967002232 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1114967002233 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1114967002234 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1114967002235 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1114967002236 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1114967002237 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1114967002238 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1114967002239 Mg++ binding site [ion binding]; other site 1114967002240 putative catalytic motif [active] 1114967002241 putative substrate binding site [chemical binding]; other site 1114967002242 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438 1114967002243 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1114967002244 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1114967002245 cell division protein FtsW; Region: ftsW; TIGR02614 1114967002246 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1114967002247 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1114967002248 active site 1114967002249 homodimer interface [polypeptide binding]; other site 1114967002250 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1114967002251 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1114967002252 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1114967002253 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1114967002254 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1114967002255 Cell division protein FtsQ; Region: FtsQ; pfam03799 1114967002256 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 1114967002257 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1114967002258 nucleotide binding site [chemical binding]; other site 1114967002259 SulA interaction site; other site 1114967002260 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 1114967002261 Protein of unknown function (DUF552); Region: DUF552; pfam04472 1114967002262 DivIVA protein; Region: DivIVA; pfam05103 1114967002263 DivIVA domain; Region: DivI1A_domain; TIGR03544 1114967002264 V-type ATP synthase subunit E; Provisional; Region: PRK02292 1114967002265 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 1114967002266 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 1114967002267 lipoprotein signal peptidase; Provisional; Region: PRK14787 1114967002268 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1114967002269 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1114967002270 RNA binding surface [nucleotide binding]; other site 1114967002271 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1114967002272 active site 1114967002273 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1114967002274 pyruvate kinase; Provisional; Region: PRK06247 1114967002275 active site 1114967002276 domain interfaces; other site 1114967002277 CrcB-like protein; Region: CRCB; pfam02537 1114967002278 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 1114967002279 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 1114967002280 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114967002281 active site 1114967002282 phosphorylation site [posttranslational modification] 1114967002283 intermolecular recognition site; other site 1114967002284 dimerization interface [polypeptide binding]; other site 1114967002285 ANTAR domain; Region: ANTAR; pfam03861 1114967002286 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1114967002287 CoenzymeA binding site [chemical binding]; other site 1114967002288 subunit interaction site [polypeptide binding]; other site 1114967002289 PHB binding site; other site 1114967002290 DNA polymerase I; Provisional; Region: PRK05755 1114967002291 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1114967002292 active site 1114967002293 metal binding site 1 [ion binding]; metal-binding site 1114967002294 putative 5' ssDNA interaction site; other site 1114967002295 metal binding site 3; metal-binding site 1114967002296 metal binding site 2 [ion binding]; metal-binding site 1114967002297 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1114967002298 putative DNA binding site [nucleotide binding]; other site 1114967002299 putative metal binding site [ion binding]; other site 1114967002300 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1114967002301 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1114967002302 active site 1114967002303 DNA binding site [nucleotide binding] 1114967002304 catalytic site [active] 1114967002305 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1114967002306 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1114967002307 FAD binding domain; Region: FAD_binding_4; pfam01565 1114967002308 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 1114967002309 Hint domain; Region: Hint_2; pfam13403 1114967002310 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 1114967002311 active site 1114967002312 putative catalytic site [active] 1114967002313 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 1114967002314 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1114967002315 RNA binding site [nucleotide binding]; other site 1114967002316 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1114967002317 RNA binding site [nucleotide binding]; other site 1114967002318 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1114967002319 RNA binding site [nucleotide binding]; other site 1114967002320 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1114967002321 RNA binding site [nucleotide binding]; other site 1114967002322 domain interface; other site 1114967002323 Htaa; Region: HtaA; pfam04213 1114967002324 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 1114967002325 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1114967002326 intersubunit interface [polypeptide binding]; other site 1114967002327 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1114967002328 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1114967002329 ABC-ATPase subunit interface; other site 1114967002330 dimer interface [polypeptide binding]; other site 1114967002331 putative PBP binding regions; other site 1114967002332 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 1114967002333 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1114967002334 Walker A/P-loop; other site 1114967002335 ATP binding site [chemical binding]; other site 1114967002336 Q-loop/lid; other site 1114967002337 ABC transporter signature motif; other site 1114967002338 Walker B; other site 1114967002339 D-loop; other site 1114967002340 H-loop/switch region; other site 1114967002341 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1114967002342 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114967002343 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1114967002344 Walker A/P-loop; other site 1114967002345 ATP binding site [chemical binding]; other site 1114967002346 Q-loop/lid; other site 1114967002347 ABC transporter signature motif; other site 1114967002348 Walker B; other site 1114967002349 D-loop; other site 1114967002350 H-loop/switch region; other site 1114967002351 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1114967002352 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1114967002353 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114967002354 Walker A/P-loop; other site 1114967002355 ATP binding site [chemical binding]; other site 1114967002356 Q-loop/lid; other site 1114967002357 ABC transporter signature motif; other site 1114967002358 Walker B; other site 1114967002359 D-loop; other site 1114967002360 H-loop/switch region; other site 1114967002361 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1114967002362 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1114967002363 CoA-binding site [chemical binding]; other site 1114967002364 ATP-binding [chemical binding]; other site 1114967002365 Htaa; Region: HtaA; pfam04213 1114967002366 Htaa; Region: HtaA; pfam04213 1114967002367 Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081 1114967002368 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1114967002369 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 1114967002370 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1114967002371 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 1114967002372 metal ion-dependent adhesion site (MIDAS); other site 1114967002373 Domain of unknown function (DUF3479); Region: DUF3479; pfam11965 1114967002374 CobN/Magnesium Chelatase; Region: CobN-Mg_chel; pfam02514 1114967002375 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1114967002376 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1114967002377 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1114967002378 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1114967002379 Walker A/P-loop; other site 1114967002380 ATP binding site [chemical binding]; other site 1114967002381 Q-loop/lid; other site 1114967002382 ABC transporter signature motif; other site 1114967002383 Walker B; other site 1114967002384 D-loop; other site 1114967002385 H-loop/switch region; other site 1114967002386 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1114967002387 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1114967002388 ABC-ATPase subunit interface; other site 1114967002389 dimer interface [polypeptide binding]; other site 1114967002390 putative PBP binding regions; other site 1114967002391 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1114967002392 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1114967002393 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114967002394 ABC transporter signature motif; other site 1114967002395 Walker B; other site 1114967002396 D-loop; other site 1114967002397 H-loop/switch region; other site 1114967002398 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114967002399 Walker A/P-loop; other site 1114967002400 ATP binding site [chemical binding]; other site 1114967002401 Q-loop/lid; other site 1114967002402 Bacteriocin (Lactococcin_972); Region: Lactococcin_972; cl09891 1114967002403 excinuclease ABC subunit B; Provisional; Region: PRK05298 1114967002404 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1114967002405 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1114967002406 nucleotide binding region [chemical binding]; other site 1114967002407 ATP-binding site [chemical binding]; other site 1114967002408 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1114967002409 UvrB/uvrC motif; Region: UVR; pfam02151 1114967002410 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 1114967002411 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1114967002412 mycothiol-dependent maleylpyruvate isomerase; Reviewed; Region: PRK09583 1114967002413 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1114967002414 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1114967002415 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1114967002416 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1114967002417 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1114967002418 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1114967002419 iron-sulfur cluster [ion binding]; other site 1114967002420 [2Fe-2S] cluster binding site [ion binding]; other site 1114967002421 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1114967002422 catalytic core [active] 1114967002423 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1114967002424 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1114967002425 GIY-YIG motif/motif A; other site 1114967002426 active site 1114967002427 catalytic site [active] 1114967002428 putative DNA binding site [nucleotide binding]; other site 1114967002429 metal binding site [ion binding]; metal-binding site 1114967002430 UvrB/uvrC motif; Region: UVR; pfam02151 1114967002431 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1114967002432 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1114967002433 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1114967002434 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1114967002435 phosphate binding site [ion binding]; other site 1114967002436 putative substrate binding pocket [chemical binding]; other site 1114967002437 dimer interface [polypeptide binding]; other site 1114967002438 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1114967002439 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1114967002440 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1114967002441 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1114967002442 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1114967002443 Phosphoglycerate kinase; Region: PGK; pfam00162 1114967002444 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1114967002445 substrate binding site [chemical binding]; other site 1114967002446 hinge regions; other site 1114967002447 ADP binding site [chemical binding]; other site 1114967002448 catalytic site [active] 1114967002449 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1114967002450 triosephosphate isomerase; Provisional; Region: PRK14567 1114967002451 substrate binding site [chemical binding]; other site 1114967002452 dimer interface [polypeptide binding]; other site 1114967002453 catalytic triad [active] 1114967002454 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 1114967002455 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1114967002456 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1114967002457 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 1114967002458 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1114967002459 active site 1114967002460 multimer interface [polypeptide binding]; other site 1114967002461 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 1114967002462 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1114967002463 B12 binding site [chemical binding]; other site 1114967002464 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1114967002465 FeS/SAM binding site; other site 1114967002466 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 1114967002467 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105 1114967002468 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 1114967002469 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1114967002470 homodimer interface [polypeptide binding]; other site 1114967002471 oligonucleotide binding site [chemical binding]; other site 1114967002472 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1114967002473 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1114967002474 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1114967002475 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114967002476 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114967002477 putative substrate translocation pore; other site 1114967002478 GTPase CgtA; Reviewed; Region: obgE; PRK12296 1114967002479 GTP1/OBG; Region: GTP1_OBG; pfam01018 1114967002480 Obg GTPase; Region: Obg; cd01898 1114967002481 G1 box; other site 1114967002482 GTP/Mg2+ binding site [chemical binding]; other site 1114967002483 Switch I region; other site 1114967002484 G2 box; other site 1114967002485 G3 box; other site 1114967002486 Switch II region; other site 1114967002487 G4 box; other site 1114967002488 G5 box; other site 1114967002489 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1114967002490 gamma-glutamyl kinase; Provisional; Region: PRK05429 1114967002491 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1114967002492 nucleotide binding site [chemical binding]; other site 1114967002493 homotetrameric interface [polypeptide binding]; other site 1114967002494 putative phosphate binding site [ion binding]; other site 1114967002495 putative allosteric binding site; other site 1114967002496 PUA domain; Region: PUA; pfam01472 1114967002497 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1114967002498 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1114967002499 putative catalytic cysteine [active] 1114967002500 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1114967002501 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1114967002502 active site 1114967002503 (T/H)XGH motif; other site 1114967002504 Oligomerisation domain; Region: Oligomerisation; pfam02410 1114967002505 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1114967002506 catalytic core [active] 1114967002507 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1114967002508 substrate binding site [chemical binding]; other site 1114967002509 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114967002510 Walker B; other site 1114967002511 D-loop; other site 1114967002512 H-loop/switch region; other site 1114967002513 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1114967002514 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1114967002515 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114967002516 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1114967002517 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1114967002518 FtsX-like permease family; Region: FtsX; pfam02687 1114967002519 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1114967002520 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1114967002521 Walker A/P-loop; other site 1114967002522 ATP binding site [chemical binding]; other site 1114967002523 Q-loop/lid; other site 1114967002524 ABC transporter signature motif; other site 1114967002525 Walker B; other site 1114967002526 D-loop; other site 1114967002527 H-loop/switch region; other site 1114967002528 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1114967002529 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114967002530 ATP binding site [chemical binding]; other site 1114967002531 Mg2+ binding site [ion binding]; other site 1114967002532 G-X-G motif; other site 1114967002533 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1114967002534 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114967002535 active site 1114967002536 phosphorylation site [posttranslational modification] 1114967002537 intermolecular recognition site; other site 1114967002538 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1114967002539 DNA binding residues [nucleotide binding] 1114967002540 Uncharacterized conserved protein [Function unknown]; Region: COG5441; cl02262 1114967002541 Uncharacterized conserved protein [Function unknown]; Region: COG5441; cl02262 1114967002542 aspartate aminotransferase; Provisional; Region: PRK05764 1114967002543 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1114967002544 catalytic residue [active] 1114967002545 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1114967002546 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1114967002547 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114967002548 Walker A/P-loop; other site 1114967002549 ATP binding site [chemical binding]; other site 1114967002550 Q-loop/lid; other site 1114967002551 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114967002552 ABC transporter signature motif; other site 1114967002553 Walker B; other site 1114967002554 D-loop; other site 1114967002555 H-loop/switch region; other site 1114967002556 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114967002557 Walker A/P-loop; other site 1114967002558 ATP binding site [chemical binding]; other site 1114967002559 Q-loop/lid; other site 1114967002560 ABC transporter signature motif; other site 1114967002561 Walker B; other site 1114967002562 D-loop; other site 1114967002563 H-loop/switch region; other site 1114967002564 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1114967002565 MarR family; Region: MarR_2; pfam12802 1114967002566 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1114967002567 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1114967002568 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 1114967002569 active site 1114967002570 substrate binding pocket [chemical binding]; other site 1114967002571 homodimer interaction site [polypeptide binding]; other site 1114967002572 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 1114967002573 active site 1114967002574 dimer interface [polypeptide binding]; other site 1114967002575 magnesium binding site [ion binding]; other site 1114967002576 L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209 1114967002577 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1114967002578 AP (apurinic/apyrimidinic) site pocket; other site 1114967002579 DNA interaction; other site 1114967002580 Metal-binding active site; metal-binding site 1114967002581 L-ribulose-5-phosphate 4-epimerase; Validated; Region: PRK06557 1114967002582 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1114967002583 intersubunit interface [polypeptide binding]; other site 1114967002584 active site 1114967002585 Zn2+ binding site [ion binding]; other site 1114967002586 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1114967002587 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1114967002588 substrate binding site [chemical binding]; other site 1114967002589 ATP binding site [chemical binding]; other site 1114967002590 benzoate transport; Region: 2A0115; TIGR00895 1114967002591 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114967002592 putative substrate translocation pore; other site 1114967002593 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1114967002594 substrate binding site [chemical binding]; other site 1114967002595 multimerization interface [polypeptide binding]; other site 1114967002596 ATP binding site [chemical binding]; other site 1114967002597 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1114967002598 thiamine phosphate binding site [chemical binding]; other site 1114967002599 active site 1114967002600 pyrophosphate binding site [ion binding]; other site 1114967002601 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 1114967002602 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 1114967002603 dimer interface [polypeptide binding]; other site 1114967002604 NAD binding site [chemical binding]; other site 1114967002605 substrate binding site [chemical binding]; other site 1114967002606 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1114967002607 malate dehydrogenase; Provisional; Region: PRK13529 1114967002608 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1114967002609 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1114967002610 NAD(P) binding site [chemical binding]; other site 1114967002611 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 1114967002612 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 1114967002613 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1114967002614 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1114967002615 HIGH motif; other site 1114967002616 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1114967002617 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1114967002618 active site 1114967002619 KMSKS motif; other site 1114967002620 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1114967002621 tRNA binding surface [nucleotide binding]; other site 1114967002622 SLBB domain; Region: SLBB; pfam10531 1114967002623 comEA protein; Region: comE; TIGR01259 1114967002624 Helix-hairpin-helix motif; Region: HHH; pfam00633 1114967002625 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1114967002626 Competence protein; Region: Competence; pfam03772 1114967002627 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 1114967002628 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1114967002629 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1114967002630 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1114967002631 ATP binding site [chemical binding]; other site 1114967002632 putative Mg++ binding site [ion binding]; other site 1114967002633 hypothetical protein; Reviewed; Region: PRK07914 1114967002634 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1114967002635 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1114967002636 Alpha amylase catalytic domain found in Amylosucrase; Region: AmyAc_Amylosucrase; cd11324 1114967002637 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1114967002638 active site 1114967002639 catalytic site [active] 1114967002640 GTP-binding protein LepA; Provisional; Region: PRK05433 1114967002641 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1114967002642 G1 box; other site 1114967002643 putative GEF interaction site [polypeptide binding]; other site 1114967002644 GTP/Mg2+ binding site [chemical binding]; other site 1114967002645 Switch I region; other site 1114967002646 G2 box; other site 1114967002647 G3 box; other site 1114967002648 Switch II region; other site 1114967002649 G4 box; other site 1114967002650 G5 box; other site 1114967002651 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 1114967002652 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1114967002653 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1114967002654 O-succinylbenzoate synthase; Provisional; Region: PRK02901 1114967002655 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 1114967002656 active site 1114967002657 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase; Region: menD; TIGR00173 1114967002658 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1114967002659 dimer interface [polypeptide binding]; other site 1114967002660 tetramer interface [polypeptide binding]; other site 1114967002661 PYR/PP interface [polypeptide binding]; other site 1114967002662 TPP binding site [chemical binding]; other site 1114967002663 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1114967002664 TPP-binding site [chemical binding]; other site 1114967002665 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 1114967002666 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1114967002667 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1114967002668 acyl-activating enzyme (AAE) consensus motif; other site 1114967002669 AMP binding site [chemical binding]; other site 1114967002670 active site 1114967002671 CoA binding site [chemical binding]; other site 1114967002672 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1114967002673 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1114967002674 substrate binding site [chemical binding]; other site 1114967002675 oxyanion hole (OAH) forming residues; other site 1114967002676 trimer interface [polypeptide binding]; other site 1114967002677 Rhomboid family; Region: Rhomboid; pfam01694 1114967002678 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1114967002679 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1114967002680 acyl-activating enzyme (AAE) consensus motif; other site 1114967002681 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1114967002682 AMP binding site [chemical binding]; other site 1114967002683 active site 1114967002684 CoA binding site [chemical binding]; other site 1114967002685 coproporphyrinogen III oxidase; Validated; Region: PRK05628 1114967002686 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1114967002687 FeS/SAM binding site; other site 1114967002688 HemN C-terminal domain; Region: HemN_C; pfam06969 1114967002689 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 1114967002690 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1114967002691 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1114967002692 active site 1114967002693 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1114967002694 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1114967002695 chaperone protein DnaJ; Provisional; Region: PRK14278 1114967002696 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1114967002697 HSP70 interaction site [polypeptide binding]; other site 1114967002698 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1114967002699 Zn binding sites [ion binding]; other site 1114967002700 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1114967002701 dimer interface [polypeptide binding]; other site 1114967002702 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 1114967002703 RNA methyltransferase, RsmE family; Region: TIGR00046 1114967002704 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1114967002705 L-iditol 2-dehydrogenase; Region: iditol_2_DH_like; cd08235 1114967002706 putative NAD(P) binding site [chemical binding]; other site 1114967002707 catalytic Zn binding site [ion binding]; other site 1114967002708 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 1114967002709 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 1114967002710 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 1114967002711 active site 1114967002712 P-loop; other site 1114967002713 phosphorylation site [posttranslational modification] 1114967002714 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1114967002715 active site 1114967002716 phosphorylation site [posttranslational modification] 1114967002717 Predicted membrane protein [Function unknown]; Region: COG2259 1114967002718 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1114967002719 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1114967002720 ATP binding site [chemical binding]; other site 1114967002721 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1114967002722 putative Mg++ binding site [ion binding]; other site 1114967002723 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1114967002724 nucleotide binding region [chemical binding]; other site 1114967002725 ATP-binding site [chemical binding]; other site 1114967002726 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1114967002727 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1114967002728 EamA-like transporter family; Region: EamA; pfam00892 1114967002729 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 1114967002730 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1114967002731 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1114967002732 Histidine kinase; Region: HisKA_3; pfam07730 1114967002733 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1114967002734 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1114967002735 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114967002736 active site 1114967002737 phosphorylation site [posttranslational modification] 1114967002738 intermolecular recognition site; other site 1114967002739 dimerization interface [polypeptide binding]; other site 1114967002740 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1114967002741 DNA binding residues [nucleotide binding] 1114967002742 dimerization interface [polypeptide binding]; other site 1114967002743 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 1114967002744 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114967002745 Walker A/P-loop; other site 1114967002746 ATP binding site [chemical binding]; other site 1114967002747 Q-loop/lid; other site 1114967002748 ABC transporter signature motif; other site 1114967002749 Walker B; other site 1114967002750 D-loop; other site 1114967002751 H-loop/switch region; other site 1114967002752 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1114967002753 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1114967002754 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 1114967002755 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 1114967002756 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1114967002757 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1114967002758 PhoH-like protein; Region: PhoH; pfam02562 1114967002759 metal-binding heat shock protein; Provisional; Region: PRK00016 1114967002760 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1114967002761 Domain of unknown function DUF21; Region: DUF21; pfam01595 1114967002762 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1114967002763 Transporter associated domain; Region: CorC_HlyC; smart01091 1114967002764 GTPase Era; Reviewed; Region: era; PRK00089 1114967002765 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1114967002766 G1 box; other site 1114967002767 GTP/Mg2+ binding site [chemical binding]; other site 1114967002768 Switch I region; other site 1114967002769 G2 box; other site 1114967002770 Switch II region; other site 1114967002771 G3 box; other site 1114967002772 G4 box; other site 1114967002773 G5 box; other site 1114967002774 KH domain; Region: KH_2; pfam07650 1114967002775 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1114967002776 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1114967002777 active site 1114967002778 potential frameshift: common BLAST hit: gi|295130501|ref|YP_003581164.1| 2-isopropylmalate synthase 1114967002779 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1114967002780 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 1114967002781 catalytic residue [active] 1114967002782 putative FPP diphosphate binding site; other site 1114967002783 putative FPP binding hydrophobic cleft; other site 1114967002784 dimer interface [polypeptide binding]; other site 1114967002785 putative IPP diphosphate binding site; other site 1114967002786 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 1114967002787 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1114967002788 Recombination protein O N terminal; Region: RecO_N; pfam11967 1114967002789 Recombination protein O C terminal; Region: RecO_C; pfam02565 1114967002790 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1114967002791 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1114967002792 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114967002793 active site 1114967002794 phosphorylation site [posttranslational modification] 1114967002795 intermolecular recognition site; other site 1114967002796 dimerization interface [polypeptide binding]; other site 1114967002797 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1114967002798 DNA binding residues [nucleotide binding] 1114967002799 dimerization interface [polypeptide binding]; other site 1114967002800 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1114967002801 metal binding site 2 [ion binding]; metal-binding site 1114967002802 putative DNA binding helix; other site 1114967002803 metal binding site 1 [ion binding]; metal-binding site 1114967002804 dimer interface [polypeptide binding]; other site 1114967002805 structural Zn2+ binding site [ion binding]; other site 1114967002806 glycyl-tRNA synthetase; Provisional; Region: PRK04173 1114967002807 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1114967002808 motif 1; other site 1114967002809 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 1114967002810 active site 1114967002811 motif 2; other site 1114967002812 motif 3; other site 1114967002813 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 1114967002814 anticodon binding site; other site 1114967002815 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 1114967002816 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 1114967002817 proximal heme binding site [chemical binding]; other site 1114967002818 distal heme binding site [chemical binding]; other site 1114967002819 putative dimer interface [polypeptide binding]; other site 1114967002820 putative Iron-sulfur protein interface [polypeptide binding]; other site 1114967002821 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 1114967002822 L-aspartate oxidase; Provisional; Region: PRK06175 1114967002823 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1114967002824 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 1114967002825 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1114967002826 4Fe-4S binding domain; Region: Fer4; pfam00037 1114967002827 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 1114967002828 putative FMN binding site [chemical binding]; other site 1114967002829 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 1114967002830 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1114967002831 putative dimer interface [polypeptide binding]; other site 1114967002832 active site pocket [active] 1114967002833 putative cataytic base [active] 1114967002834 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1114967002835 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1114967002836 FMN binding site [chemical binding]; other site 1114967002837 active site 1114967002838 catalytic residues [active] 1114967002839 substrate binding site [chemical binding]; other site 1114967002840 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1114967002841 Zn2+ binding site [ion binding]; other site 1114967002842 Mg2+ binding site [ion binding]; other site 1114967002843 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1114967002844 Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424 1114967002845 DNA primase; Validated; Region: dnaG; PRK05667 1114967002846 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1114967002847 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1114967002848 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1114967002849 active site 1114967002850 metal binding site [ion binding]; metal-binding site 1114967002851 interdomain interaction site; other site 1114967002852 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1114967002853 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 1114967002854 DNA-directed RNA polymerase specialized sigma subunit [Transcription]; Region: FliA; COG1191 1114967002855 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1114967002856 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1114967002857 DNA binding residues [nucleotide binding] 1114967002858 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1114967002859 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 1114967002860 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1114967002861 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1114967002862 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 1114967002863 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 1114967002864 active site 1114967002865 homotetramer interface [polypeptide binding]; other site 1114967002866 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 1114967002867 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 1114967002868 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1114967002869 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1114967002870 dimer interface [polypeptide binding]; other site 1114967002871 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114967002872 catalytic residue [active] 1114967002873 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1114967002874 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114967002875 DNA-binding site [nucleotide binding]; DNA binding site 1114967002876 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1114967002877 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114967002878 homodimer interface [polypeptide binding]; other site 1114967002879 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1114967002880 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1114967002881 active site 1114967002882 multimer interface [polypeptide binding]; other site 1114967002883 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1114967002884 predicted active site [active] 1114967002885 catalytic triad [active] 1114967002886 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1114967002887 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 1114967002888 inhibitor-cofactor binding pocket; inhibition site 1114967002889 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114967002890 catalytic residue [active] 1114967002891 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1114967002892 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1114967002893 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1114967002894 potential protein location (hypothetical protein TIA2EST22_04830 [Propionibacterium acnes TypeIA2 P.acn17]) that overlaps RNA (tRNA-M) 1114967002895 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1114967002896 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1114967002897 MoxR-like ATPases [General function prediction only]; Region: COG0714 1114967002898 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114967002899 Walker A motif; other site 1114967002900 ATP binding site [chemical binding]; other site 1114967002901 Walker B motif; other site 1114967002902 arginine finger; other site 1114967002903 Protein of unknown function DUF58; Region: DUF58; pfam01882 1114967002904 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1114967002905 hypothetical protein; Provisional; Region: PRK13685 1114967002906 von Willebrand factor type A domain; Region: VWA_2; pfam13519 1114967002907 metal ion-dependent adhesion site (MIDAS); other site 1114967002908 Protein-interacting Bro1-like domain of mammalian Alix and related domains; Region: BRO1_Alix_like; cl14649 1114967002909 von Willebrand factor type A domain; Region: VWA_2; pfam13519 1114967002910 metal ion-dependent adhesion site (MIDAS); other site 1114967002911 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1114967002912 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1114967002913 catalytic residue [active] 1114967002914 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 1114967002915 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1114967002916 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1114967002917 dimer interface [polypeptide binding]; other site 1114967002918 active site 1114967002919 acyl carrier protein; Provisional; Region: acpP; PRK00982 1114967002920 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1114967002921 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1114967002922 dimer interface [polypeptide binding]; other site 1114967002923 active site 1114967002924 CoA binding pocket [chemical binding]; other site 1114967002925 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1114967002926 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1114967002927 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1114967002928 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1114967002929 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cl00252 1114967002930 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1114967002931 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114967002932 putative substrate translocation pore; other site 1114967002933 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114967002934 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1114967002935 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1114967002936 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1114967002937 dimer interface [polypeptide binding]; other site 1114967002938 TPP-binding site [chemical binding]; other site 1114967002939 Endo-beta-N-acetylglucosaminidases are bacterial chitinases that hydrolyze the chitin core of various asparagine (N)-linked glycans and glycoproteins. The endo-beta-N-acetylglucosaminidases have a glycosyl hydrolase family 18 (GH18) catalytic domain; Region: GH18_EndoS-like; cd06542 1114967002940 active site 1114967002941 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 1114967002942 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 1114967002943 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 1114967002944 Isochorismatase family; Region: Isochorismatase; pfam00857 1114967002945 catalytic triad [active] 1114967002946 metal binding site [ion binding]; metal-binding site 1114967002947 conserved cis-peptide bond; other site 1114967002948 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1114967002949 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1114967002950 active site 1114967002951 catalytic tetrad [active] 1114967002952 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1114967002953 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1114967002954 active site 1114967002955 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1114967002956 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1114967002957 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1114967002958 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1114967002959 dihydroorotase; Validated; Region: pyrC; PRK09357 1114967002960 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1114967002961 active site 1114967002962 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1114967002963 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 1114967002964 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1114967002965 catalytic site [active] 1114967002966 subunit interface [polypeptide binding]; other site 1114967002967 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1114967002968 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1114967002969 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1114967002970 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1114967002971 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1114967002972 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1114967002973 MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245 1114967002974 substrate binding site [chemical binding]; other site 1114967002975 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 1114967002976 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 1114967002977 FAD binding pocket [chemical binding]; other site 1114967002978 FAD binding motif [chemical binding]; other site 1114967002979 phosphate binding motif [ion binding]; other site 1114967002980 beta-alpha-beta structure motif; other site 1114967002981 NAD binding pocket [chemical binding]; other site 1114967002982 Iron coordination center [ion binding]; other site 1114967002983 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 1114967002984 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 1114967002985 heterodimer interface [polypeptide binding]; other site 1114967002986 active site 1114967002987 FMN binding site [chemical binding]; other site 1114967002988 homodimer interface [polypeptide binding]; other site 1114967002989 substrate binding site [chemical binding]; other site 1114967002990 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1114967002991 active site 1114967002992 dimer interface [polypeptide binding]; other site 1114967002993 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1114967002994 active site 1114967002995 Fructosamine kinase; Region: Fructosamin_kin; cl17579 1114967002996 Phosphotransferase enzyme family; Region: APH; pfam01636 1114967002997 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 1114967002998 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1114967002999 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1114967003000 Competence-damaged protein; Region: CinA; pfam02464 1114967003001 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1114967003002 non-specific DNA binding site [nucleotide binding]; other site 1114967003003 salt bridge; other site 1114967003004 sequence-specific DNA binding site [nucleotide binding]; other site 1114967003005 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1114967003006 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1114967003007 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1114967003008 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 1114967003009 recombinase A; Provisional; Region: recA; PRK09354 1114967003010 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1114967003011 hexamer interface [polypeptide binding]; other site 1114967003012 Walker A motif; other site 1114967003013 ATP binding site [chemical binding]; other site 1114967003014 Walker B motif; other site 1114967003015 recombination regulator RecX; Reviewed; Region: recX; PRK00117 1114967003016 hypothetical protein; Provisional; Region: PRK12705 1114967003017 KH domain; Region: KH_1; pfam00013 1114967003018 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1114967003019 Zn2+ binding site [ion binding]; other site 1114967003020 Mg2+ binding site [ion binding]; other site 1114967003021 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 1114967003022 active site 1114967003023 catalytic residues [active] 1114967003024 Predicted membrane protein [Function unknown]; Region: COG1288 1114967003025 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1114967003026 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 1114967003027 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1114967003028 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1114967003029 FeS/SAM binding site; other site 1114967003030 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 1114967003031 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1114967003032 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1114967003033 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1114967003034 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1114967003035 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1114967003036 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1114967003037 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1114967003038 HflX GTPase family; Region: HflX; cd01878 1114967003039 G1 box; other site 1114967003040 GTP/Mg2+ binding site [chemical binding]; other site 1114967003041 Switch I region; other site 1114967003042 G2 box; other site 1114967003043 G3 box; other site 1114967003044 Switch II region; other site 1114967003045 G4 box; other site 1114967003046 G5 box; other site 1114967003047 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1114967003048 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1114967003049 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1114967003050 putative Mg++ binding site [ion binding]; other site 1114967003051 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1114967003052 LexA repressor; Validated; Region: PRK00215 1114967003053 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1114967003054 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1114967003055 Catalytic site [active] 1114967003056 ATP cone domain; Region: ATP-cone; pfam03477 1114967003057 vitamin B12-dependent ribonucleotide reductase; Validated; Region: PRK06556 1114967003058 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 1114967003059 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 1114967003060 active site 1114967003061 dimer interface [polypeptide binding]; other site 1114967003062 effector binding site; other site 1114967003063 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1114967003064 TSCPD domain; Region: TSCPD; pfam12637 1114967003065 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1114967003066 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1114967003067 Ligand Binding Site [chemical binding]; other site 1114967003068 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1114967003069 Ligand Binding Site [chemical binding]; other site 1114967003070 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 1114967003071 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1114967003072 ATP binding site [chemical binding]; other site 1114967003073 putative Mg++ binding site [ion binding]; other site 1114967003074 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1114967003075 nucleotide binding region [chemical binding]; other site 1114967003076 ATP-binding site [chemical binding]; other site 1114967003077 Helicase associated domain (HA2); Region: HA2; pfam04408 1114967003078 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 1114967003079 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 1114967003080 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 1114967003081 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1114967003082 active site 1114967003083 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1114967003084 catalytic triad [active] 1114967003085 dimer interface [polypeptide binding]; other site 1114967003086 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 1114967003087 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1114967003088 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1114967003089 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1114967003090 Sigma-70, region 4; Region: Sigma70_r4; pfam04545 1114967003091 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 1114967003092 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1114967003093 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1114967003094 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1114967003095 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1114967003096 DNA binding residues [nucleotide binding] 1114967003097 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 1114967003098 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1114967003099 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1114967003100 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1114967003101 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114967003102 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1114967003103 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1114967003104 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1114967003105 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1114967003106 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1114967003107 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 1114967003108 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1114967003109 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1114967003110 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1114967003111 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 1114967003112 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114967003113 Mg2+ binding site [ion binding]; other site 1114967003114 G-X-G motif; other site 1114967003115 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1114967003116 anchoring element; other site 1114967003117 dimer interface [polypeptide binding]; other site 1114967003118 ATP binding site [chemical binding]; other site 1114967003119 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1114967003120 active site 1114967003121 metal binding site [ion binding]; metal-binding site 1114967003122 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1114967003123 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 1114967003124 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 1114967003125 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 1114967003126 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114967003127 putative substrate translocation pore; other site 1114967003128 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 1114967003129 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1114967003130 CAP-like domain; other site 1114967003131 active site 1114967003132 primary dimer interface [polypeptide binding]; other site 1114967003133 Uncharacterized conserved protein [Function unknown]; Region: COG4850 1114967003134 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 1114967003135 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 1114967003136 Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; cl17415 1114967003137 thymidine kinase; Provisional; Region: PRK04296 1114967003138 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 1114967003139 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 1114967003140 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 1114967003141 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 1114967003142 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1114967003143 trimer interface [polypeptide binding]; other site 1114967003144 active site 1114967003145 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 1114967003146 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1114967003147 ssDNA binding site; other site 1114967003148 generic binding surface II; other site 1114967003149 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1114967003150 TrkA-N domain; Region: TrkA_N; pfam02254 1114967003151 TrkA-C domain; Region: TrkA_C; pfam02080 1114967003152 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1114967003153 TrkA-N domain; Region: TrkA_N; pfam02254 1114967003154 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1114967003155 TRAM domain; Region: TRAM; cl01282 1114967003156 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1114967003157 aconitate hydratase; Validated; Region: PRK09277 1114967003158 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1114967003159 substrate binding site [chemical binding]; other site 1114967003160 ligand binding site [chemical binding]; other site 1114967003161 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1114967003162 substrate binding site [chemical binding]; other site 1114967003163 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1114967003164 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1114967003165 TPP-binding site; other site 1114967003166 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1114967003167 PYR/PP interface [polypeptide binding]; other site 1114967003168 dimer interface [polypeptide binding]; other site 1114967003169 TPP binding site [chemical binding]; other site 1114967003170 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1114967003171 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 1114967003172 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1114967003173 catalytic site [active] 1114967003174 putative active site [active] 1114967003175 putative substrate binding site [chemical binding]; other site 1114967003176 HRDC domain; Region: HRDC; pfam00570 1114967003177 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 1114967003178 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 1114967003179 SelR domain; Region: SelR; pfam01641 1114967003180 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 1114967003181 active site 1114967003182 YheO-like PAS domain; Region: PAS_6; pfam08348 1114967003183 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 1114967003184 HTH domain; Region: HTH_22; pfam13309 1114967003185 tryptophanase/L-cysteine desulfhydrase, PLP-dependent; Provisional; Region: tnaA; PRK13238 1114967003186 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1114967003187 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1114967003188 catalytic residue [active] 1114967003189 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1114967003190 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 1114967003191 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1114967003192 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1114967003193 putative NAD(P) binding site [chemical binding]; other site 1114967003194 putative substrate binding site [chemical binding]; other site 1114967003195 catalytic Zn binding site [ion binding]; other site 1114967003196 structural Zn binding site [ion binding]; other site 1114967003197 dimer interface [polypeptide binding]; other site 1114967003198 LrgB-like family; Region: LrgB; cl00596 1114967003199 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1114967003200 Histidine kinase; Region: HisKA_3; pfam07730 1114967003201 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114967003202 ATP binding site [chemical binding]; other site 1114967003203 Mg2+ binding site [ion binding]; other site 1114967003204 G-X-G motif; other site 1114967003205 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1114967003206 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114967003207 active site 1114967003208 phosphorylation site [posttranslational modification] 1114967003209 intermolecular recognition site; other site 1114967003210 dimerization interface [polypeptide binding]; other site 1114967003211 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1114967003212 DNA binding residues [nucleotide binding] 1114967003213 dimerization interface [polypeptide binding]; other site 1114967003214 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 1114967003215 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 1114967003216 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1114967003217 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1114967003218 active site 1114967003219 dimer interface [polypeptide binding]; other site 1114967003220 motif 1; other site 1114967003221 motif 2; other site 1114967003222 motif 3; other site 1114967003223 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1114967003224 anticodon binding site; other site 1114967003225 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 1114967003226 nucleotide binding site/active site [active] 1114967003227 HIT family signature motif; other site 1114967003228 catalytic residue [active] 1114967003229 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1114967003230 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1114967003231 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1114967003232 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 1114967003233 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 1114967003234 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1114967003235 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1114967003236 lipoyl attachment site [posttranslational modification]; other site 1114967003237 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1114967003238 Double zinc ribbon; Region: DZR; pfam12773 1114967003239 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1114967003240 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1114967003241 phosphopeptide binding site; other site 1114967003242 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1114967003243 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1114967003244 DNA binding residues [nucleotide binding] 1114967003245 Bifunctional nuclease; Region: DNase-RNase; pfam02577 1114967003246 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1114967003247 DNA binding residues [nucleotide binding] 1114967003248 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1114967003249 putative dimer interface [polypeptide binding]; other site 1114967003250 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 1114967003251 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114967003252 pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated; Region: PRK06555 1114967003253 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 1114967003254 active site 1114967003255 ADP/pyrophosphate binding site [chemical binding]; other site 1114967003256 fructose-1,6-bisphosphate binding site; other site 1114967003257 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 1114967003258 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 1114967003259 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1114967003260 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1114967003261 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1114967003262 Uncharacterized conserved protein [Function unknown]; Region: COG1739 1114967003263 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1114967003264 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1114967003265 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1114967003266 PAC2 family; Region: PAC2; pfam09754 1114967003267 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 1114967003268 active site 1114967003269 acyl-CoA esterase; Provisional; Region: PRK10673 1114967003270 hypothetical protein; Provisional; Region: PRK03298 1114967003271 DivIVA protein; Region: DivIVA; pfam05103 1114967003272 V-type ATP synthase subunit E; Provisional; Region: PRK01558 1114967003273 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1114967003274 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 1114967003275 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1114967003276 dimer interface [polypeptide binding]; other site 1114967003277 substrate binding site [chemical binding]; other site 1114967003278 metal binding site [ion binding]; metal-binding site 1114967003279 phosphoglucomutase; Validated; Region: PRK07564 1114967003280 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 1114967003281 active site 1114967003282 substrate binding site [chemical binding]; other site 1114967003283 metal binding site [ion binding]; metal-binding site 1114967003284 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1114967003285 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 1114967003286 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1114967003287 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114967003288 motif II; other site 1114967003289 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1114967003290 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 1114967003291 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1114967003292 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1114967003293 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1114967003294 active site turn [active] 1114967003295 phosphorylation site [posttranslational modification] 1114967003296 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1114967003297 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 1114967003298 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1114967003299 HPr interaction site; other site 1114967003300 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1114967003301 active site 1114967003302 phosphorylation site [posttranslational modification] 1114967003303 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1114967003304 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1114967003305 nudix motif; other site 1114967003306 glycogen branching enzyme; Provisional; Region: PRK12313 1114967003307 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1114967003308 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1114967003309 active site 1114967003310 catalytic site [active] 1114967003311 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1114967003312 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 1114967003313 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 1114967003314 trehalose synthase; Region: treS_nterm; TIGR02456 1114967003315 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 1114967003316 active site 1114967003317 catalytic site [active] 1114967003318 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 1114967003319 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 1114967003320 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1114967003321 active site 1114967003322 homodimer interface [polypeptide binding]; other site 1114967003323 catalytic site [active] 1114967003324 acceptor binding site [chemical binding]; other site 1114967003325 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1114967003326 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1114967003327 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1114967003328 active site 1114967003329 catalytic site [active] 1114967003330 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1114967003331 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1114967003332 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1114967003333 catalytic residue [active] 1114967003334 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 1114967003335 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1114967003336 Ligand Binding Site [chemical binding]; other site 1114967003337 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 1114967003338 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 1114967003339 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1114967003340 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1114967003341 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1114967003342 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1114967003343 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1114967003344 GatB domain; Region: GatB_Yqey; smart00845 1114967003345 TIGR03085 family protein; Region: TIGR03085 1114967003346 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1114967003347 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1114967003348 anthranilate synthase component I; Provisional; Region: PRK13571 1114967003349 anthranilate synthase component I; Provisional; Region: PRK13571 1114967003350 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; cl17850 1114967003351 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1114967003352 active site 1114967003353 ribulose/triose binding site [chemical binding]; other site 1114967003354 phosphate binding site [ion binding]; other site 1114967003355 substrate (anthranilate) binding pocket [chemical binding]; other site 1114967003356 product (indole) binding pocket [chemical binding]; other site 1114967003357 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1114967003358 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1114967003359 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114967003360 catalytic residue [active] 1114967003361 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1114967003362 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1114967003363 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1114967003364 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1114967003365 active site 1114967003366 dimer interface [polypeptide binding]; other site 1114967003367 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1114967003368 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1114967003369 active site 1114967003370 FMN binding site [chemical binding]; other site 1114967003371 substrate binding site [chemical binding]; other site 1114967003372 3Fe-4S cluster binding site [ion binding]; other site 1114967003373 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1114967003374 domain interface; other site 1114967003375 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 1114967003376 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1114967003377 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1114967003378 Beta-lactamase; Region: Beta-lactamase; cl17358 1114967003379 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 1114967003380 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1114967003381 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1114967003382 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1114967003383 putative active site [active] 1114967003384 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 1114967003385 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1114967003386 putative active site [active] 1114967003387 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1114967003388 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 1114967003389 active site turn [active] 1114967003390 phosphorylation site [posttranslational modification] 1114967003391 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1114967003392 Uncharacterized conserved protein [Function unknown]; Region: COG3589 1114967003393 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1114967003394 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1114967003395 beta-galactosidase; Region: BGL; TIGR03356 1114967003396 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1114967003397 active site 1114967003398 P-loop; other site 1114967003399 phosphorylation site [posttranslational modification] 1114967003400 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1114967003401 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1114967003402 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1114967003403 methionine cluster; other site 1114967003404 active site 1114967003405 phosphorylation site [posttranslational modification] 1114967003406 metal binding site [ion binding]; metal-binding site 1114967003407 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1114967003408 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 1114967003409 active site 1114967003410 PHP Thumb interface [polypeptide binding]; other site 1114967003411 metal binding site [ion binding]; metal-binding site 1114967003412 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1114967003413 generic binding surface II; other site 1114967003414 generic binding surface I; other site 1114967003415 histidinol dehydrogenase; Region: hisD; TIGR00069 1114967003416 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1114967003417 NAD binding site [chemical binding]; other site 1114967003418 dimerization interface [polypeptide binding]; other site 1114967003419 product binding site; other site 1114967003420 substrate binding site [chemical binding]; other site 1114967003421 zinc binding site [ion binding]; other site 1114967003422 catalytic residues [active] 1114967003423 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 1114967003424 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1114967003425 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114967003426 homodimer interface [polypeptide binding]; other site 1114967003427 catalytic residue [active] 1114967003428 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1114967003429 putative active site pocket [active] 1114967003430 4-fold oligomerization interface [polypeptide binding]; other site 1114967003431 metal binding residues [ion binding]; metal-binding site 1114967003432 3-fold/trimer interface [polypeptide binding]; other site 1114967003433 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 1114967003434 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1114967003435 putative active site [active] 1114967003436 oxyanion strand; other site 1114967003437 catalytic triad [active] 1114967003438 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1114967003439 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 1114967003440 catalytic residues [active] 1114967003441 hypothetical protein; Validated; Region: PRK00110 1114967003442 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 1114967003443 active site 1114967003444 putative DNA-binding cleft [nucleotide binding]; other site 1114967003445 dimer interface [polypeptide binding]; other site 1114967003446 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1114967003447 RuvA N terminal domain; Region: RuvA_N; pfam01330 1114967003448 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1114967003449 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114967003450 Walker A motif; other site 1114967003451 ATP binding site [chemical binding]; other site 1114967003452 Walker B motif; other site 1114967003453 arginine finger; other site 1114967003454 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1114967003455 Preprotein translocase subunit; Region: YajC; pfam02699 1114967003456 Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342 1114967003457 Protein export membrane protein; Region: SecD_SecF; cl14618 1114967003458 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1114967003459 Protein export membrane protein; Region: SecD_SecF; pfam02355 1114967003460 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1114967003461 active site 1114967003462 potential frameshift: common BLAST hit: gi|295130723|ref|YP_003581386.1| Ion channel 1114967003463 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1114967003464 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1114967003465 Zn2+ binding site [ion binding]; other site 1114967003466 Mg2+ binding site [ion binding]; other site 1114967003467 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1114967003468 synthetase active site [active] 1114967003469 NTP binding site [chemical binding]; other site 1114967003470 metal binding site [ion binding]; metal-binding site 1114967003471 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1114967003472 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1114967003473 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1114967003474 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1114967003475 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1114967003476 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1114967003477 histidyl-tRNA synthetase; Region: hisS; TIGR00442 1114967003478 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1114967003479 dimer interface [polypeptide binding]; other site 1114967003480 motif 1; other site 1114967003481 active site 1114967003482 motif 2; other site 1114967003483 motif 3; other site 1114967003484 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1114967003485 anticodon binding site; other site 1114967003486 Protein of unknown function (DUF998); Region: DUF998; pfam06197 1114967003487 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1114967003488 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1114967003489 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1114967003490 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 1114967003491 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1114967003492 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 1114967003493 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 1114967003494 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 1114967003495 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1114967003496 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1114967003497 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1114967003498 dimer interface [polypeptide binding]; other site 1114967003499 anticodon binding site; other site 1114967003500 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1114967003501 homodimer interface [polypeptide binding]; other site 1114967003502 motif 1; other site 1114967003503 active site 1114967003504 motif 2; other site 1114967003505 GAD domain; Region: GAD; pfam02938 1114967003506 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1114967003507 active site 1114967003508 motif 3; other site 1114967003509 recombination factor protein RarA; Reviewed; Region: PRK13342 1114967003510 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114967003511 Walker A motif; other site 1114967003512 ATP binding site [chemical binding]; other site 1114967003513 Walker B motif; other site 1114967003514 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1114967003515 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1114967003516 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1114967003517 motif 1; other site 1114967003518 active site 1114967003519 motif 2; other site 1114967003520 motif 3; other site 1114967003521 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1114967003522 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 1114967003523 YceG-like family; Region: YceG; pfam02618 1114967003524 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1114967003525 dimerization interface [polypeptide binding]; other site 1114967003526 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1114967003527 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1114967003528 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1114967003529 shikimate binding site; other site 1114967003530 NAD(P) binding site [chemical binding]; other site 1114967003531 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1114967003532 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1114967003533 Tetramer interface [polypeptide binding]; other site 1114967003534 active site 1114967003535 FMN-binding site [chemical binding]; other site 1114967003536 shikimate kinase; Reviewed; Region: aroK; PRK00131 1114967003537 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1114967003538 ADP binding site [chemical binding]; other site 1114967003539 magnesium binding site [ion binding]; other site 1114967003540 putative shikimate binding site; other site 1114967003541 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1114967003542 dimer interface [polypeptide binding]; other site 1114967003543 active site 1114967003544 metal binding site [ion binding]; metal-binding site 1114967003545 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 1114967003546 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 1114967003547 putative active site [active] 1114967003548 putative metal binding site [ion binding]; other site 1114967003549 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 1114967003550 elongation factor P; Validated; Region: PRK00529 1114967003551 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1114967003552 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1114967003553 RNA binding site [nucleotide binding]; other site 1114967003554 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1114967003555 RNA binding site [nucleotide binding]; other site 1114967003556 transcription antitermination factor NusB; Region: nusB; TIGR01951 1114967003557 putative RNA binding site [nucleotide binding]; other site 1114967003558 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1114967003559 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1114967003560 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1114967003561 catalytic site [active] 1114967003562 G-X2-G-X-G-K; other site 1114967003563 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 1114967003564 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1114967003565 Flavoprotein; Region: Flavoprotein; pfam02441 1114967003566 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1114967003567 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1114967003568 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1114967003569 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1114967003570 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1114967003571 primosome assembly protein PriA; Provisional; Region: PRK14873 1114967003572 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1114967003573 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1114967003574 putative active site [active] 1114967003575 substrate binding site [chemical binding]; other site 1114967003576 putative cosubstrate binding site; other site 1114967003577 catalytic site [active] 1114967003578 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1114967003579 substrate binding site [chemical binding]; other site 1114967003580 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 1114967003581 putative RNA binding site [nucleotide binding]; other site 1114967003582 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1114967003583 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114967003584 S-adenosylmethionine binding site [chemical binding]; other site 1114967003585 CAMP factor (Cfa); Region: CAMP_factor; pfam07373 1114967003586 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1114967003587 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1114967003588 substrate binding site [chemical binding]; other site 1114967003589 hexamer interface [polypeptide binding]; other site 1114967003590 metal binding site [ion binding]; metal-binding site 1114967003591 PAC2 family; Region: PAC2; pfam09754 1114967003592 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1114967003593 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1114967003594 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114967003595 motif II; other site 1114967003596 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 1114967003597 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114967003598 S-adenosylmethionine binding site [chemical binding]; other site 1114967003599 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 1114967003600 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1114967003601 Predicted membrane protein [Function unknown]; Region: COG1511 1114967003602 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1114967003603 ABC transporter; Region: ABC_tran; pfam00005 1114967003604 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1114967003605 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114967003606 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1114967003607 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 1114967003608 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 1114967003609 active site 1114967003610 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 1114967003611 prephenate dehydrogenase; Validated; Region: PRK06545 1114967003612 prephenate dehydrogenase; Validated; Region: PRK08507 1114967003613 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cd02116 1114967003614 cytidylate kinase; Provisional; Region: cmk; PRK00023 1114967003615 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1114967003616 CMP-binding site; other site 1114967003617 GTP-binding protein Der; Reviewed; Region: PRK03003 1114967003618 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1114967003619 G1 box; other site 1114967003620 GTP/Mg2+ binding site [chemical binding]; other site 1114967003621 Switch I region; other site 1114967003622 G2 box; other site 1114967003623 Switch II region; other site 1114967003624 G3 box; other site 1114967003625 G4 box; other site 1114967003626 G5 box; other site 1114967003627 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1114967003628 G1 box; other site 1114967003629 GTP/Mg2+ binding site [chemical binding]; other site 1114967003630 Switch I region; other site 1114967003631 G2 box; other site 1114967003632 G3 box; other site 1114967003633 Switch II region; other site 1114967003634 G4 box; other site 1114967003635 G5 box; other site 1114967003636 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1114967003637 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1114967003638 substrate binding site [chemical binding]; other site 1114967003639 dimer interface [polypeptide binding]; other site 1114967003640 ATP binding site [chemical binding]; other site 1114967003641 deoxyribose mutarotase_like; Region: deoxyribose_mutarotase; cd09269 1114967003642 active site 1114967003643 catalytic residues [active] 1114967003644 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 1114967003645 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114967003646 putative substrate translocation pore; other site 1114967003647 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1114967003648 intersubunit interface [polypeptide binding]; other site 1114967003649 active site 1114967003650 catalytic residue [active] 1114967003651 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1114967003652 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1114967003653 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114967003654 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1114967003655 active site 1114967003656 motif I; other site 1114967003657 motif II; other site 1114967003658 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1114967003659 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 1114967003660 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1114967003661 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1114967003662 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1114967003663 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1114967003664 putative DNA binding site [nucleotide binding]; other site 1114967003665 putative Zn2+ binding site [ion binding]; other site 1114967003666 AsnC family; Region: AsnC_trans_reg; pfam01037 1114967003667 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 1114967003668 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1114967003669 putative active site [active] 1114967003670 catalytic triad [active] 1114967003671 putative dimer interface [polypeptide binding]; other site 1114967003672 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 1114967003673 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 1114967003674 Ligand binding site; other site 1114967003675 Putative Catalytic site; other site 1114967003676 DXD motif; other site 1114967003677 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 1114967003678 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 1114967003679 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1114967003680 putative active site [active] 1114967003681 catalytic site [active] 1114967003682 putative metal binding site [ion binding]; other site 1114967003683 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 1114967003684 dimer interface [polypeptide binding]; other site 1114967003685 pyridoxamine kinase; Validated; Region: PRK05756 1114967003686 pyridoxal binding site [chemical binding]; other site 1114967003687 ATP binding site [chemical binding]; other site 1114967003688 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1114967003689 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1114967003690 non-specific DNA binding site [nucleotide binding]; other site 1114967003691 salt bridge; other site 1114967003692 sequence-specific DNA binding site [nucleotide binding]; other site 1114967003693 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1114967003694 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 1114967003695 putative active site [active] 1114967003696 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 1114967003697 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1114967003698 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1114967003699 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1114967003700 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1114967003701 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1114967003702 dimerization interface [polypeptide binding]; other site 1114967003703 putative DNA binding site [nucleotide binding]; other site 1114967003704 putative Zn2+ binding site [ion binding]; other site 1114967003705 CAMP factor (Cfa); Region: CAMP_factor; pfam07373 1114967003706 hypothetical protein; Provisional; Region: PRK09256 1114967003707 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1114967003708 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114967003709 putative substrate translocation pore; other site 1114967003710 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1114967003711 MarR family; Region: MarR; pfam01047 1114967003712 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 1114967003713 Fe-S cluster binding site [ion binding]; other site 1114967003714 DNA binding site [nucleotide binding] 1114967003715 active site 1114967003716 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 1114967003717 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 1114967003718 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1114967003719 gamma subunit interface [polypeptide binding]; other site 1114967003720 epsilon subunit interface [polypeptide binding]; other site 1114967003721 LBP interface [polypeptide binding]; other site 1114967003722 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1114967003723 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1114967003724 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1114967003725 alpha subunit interaction interface [polypeptide binding]; other site 1114967003726 Walker A motif; other site 1114967003727 ATP binding site [chemical binding]; other site 1114967003728 Walker B motif; other site 1114967003729 inhibitor binding site; inhibition site 1114967003730 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1114967003731 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1114967003732 core domain interface [polypeptide binding]; other site 1114967003733 delta subunit interface [polypeptide binding]; other site 1114967003734 epsilon subunit interface [polypeptide binding]; other site 1114967003735 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1114967003736 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1114967003737 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1114967003738 beta subunit interaction interface [polypeptide binding]; other site 1114967003739 Walker A motif; other site 1114967003740 ATP binding site [chemical binding]; other site 1114967003741 Walker B motif; other site 1114967003742 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1114967003743 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210 1114967003744 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1114967003745 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1114967003746 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1114967003747 F0F1 ATP synthase subunit C; Validated; Region: PRK07558 1114967003748 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1114967003749 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1114967003750 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 1114967003751 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1114967003752 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1114967003753 putative catalytic motif [active] 1114967003754 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1114967003755 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 1114967003756 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114967003757 S-adenosylmethionine binding site [chemical binding]; other site 1114967003758 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1114967003759 PCRF domain; Region: PCRF; pfam03462 1114967003760 RF-1 domain; Region: RF-1; pfam00472 1114967003761 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1114967003762 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1114967003763 transcription termination factor Rho; Provisional; Region: PRK12608 1114967003764 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1114967003765 RNA binding site [nucleotide binding]; other site 1114967003766 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1114967003767 Walker A motif; other site 1114967003768 ATP binding site [chemical binding]; other site 1114967003769 Walker B motif; other site 1114967003770 homoserine kinase; Provisional; Region: PRK01212 1114967003771 threonine synthase; Reviewed; Region: PRK06721 1114967003772 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1114967003773 homodimer interface [polypeptide binding]; other site 1114967003774 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114967003775 catalytic residue [active] 1114967003776 homoserine dehydrogenase; Provisional; Region: PRK06349 1114967003777 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1114967003778 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1114967003779 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1114967003780 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1114967003781 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1114967003782 active site 1114967003783 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1114967003784 substrate binding site [chemical binding]; other site 1114967003785 catalytic residues [active] 1114967003786 dimer interface [polypeptide binding]; other site 1114967003787 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 1114967003788 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1114967003789 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1114967003790 TPP-binding site [chemical binding]; other site 1114967003791 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1114967003792 Transcription factor WhiB; Region: Whib; pfam02467 1114967003793 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 1114967003794 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1114967003795 Histidine kinase; Region: HisKA_2; pfam07568 1114967003796 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114967003797 ATP binding site [chemical binding]; other site 1114967003798 Mg2+ binding site [ion binding]; other site 1114967003799 G-X-G motif; other site 1114967003800 anti-sigma factor, TIGR02949 family; Region: anti_SigH_actin 1114967003801 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 1114967003802 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1114967003803 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1114967003804 DNA binding residues [nucleotide binding] 1114967003805 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1114967003806 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1114967003807 hinge; other site 1114967003808 active site 1114967003809 Predicted GTPases [General function prediction only]; Region: COG1162 1114967003810 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1114967003811 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1114967003812 GTP/Mg2+ binding site [chemical binding]; other site 1114967003813 G4 box; other site 1114967003814 G5 box; other site 1114967003815 G1 box; other site 1114967003816 Switch I region; other site 1114967003817 G2 box; other site 1114967003818 G3 box; other site 1114967003819 Switch II region; other site 1114967003820 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 1114967003821 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1114967003822 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 1114967003823 active site 1114967003824 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 1114967003825 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 1114967003826 ligand binding site [chemical binding]; other site 1114967003827 NAD binding site [chemical binding]; other site 1114967003828 tetramer interface [polypeptide binding]; other site 1114967003829 catalytic site [active] 1114967003830 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 1114967003831 L-serine binding site [chemical binding]; other site 1114967003832 ACT domain interface; other site 1114967003833 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1114967003834 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1114967003835 Walker A/P-loop; other site 1114967003836 ATP binding site [chemical binding]; other site 1114967003837 Q-loop/lid; other site 1114967003838 ABC transporter signature motif; other site 1114967003839 Walker B; other site 1114967003840 D-loop; other site 1114967003841 H-loop/switch region; other site 1114967003842 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1114967003843 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1114967003844 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1114967003845 Walker A/P-loop; other site 1114967003846 ATP binding site [chemical binding]; other site 1114967003847 Q-loop/lid; other site 1114967003848 ABC transporter signature motif; other site 1114967003849 Walker B; other site 1114967003850 D-loop; other site 1114967003851 H-loop/switch region; other site 1114967003852 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1114967003853 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114967003854 dimer interface [polypeptide binding]; other site 1114967003855 conserved gate region; other site 1114967003856 putative PBP binding loops; other site 1114967003857 ABC-ATPase subunit interface; other site 1114967003858 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1114967003859 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114967003860 dimer interface [polypeptide binding]; other site 1114967003861 conserved gate region; other site 1114967003862 putative PBP binding loops; other site 1114967003863 ABC-ATPase subunit interface; other site 1114967003864 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1114967003865 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 1114967003866 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1114967003867 sequence-specific DNA binding site [nucleotide binding]; other site 1114967003868 salt bridge; other site 1114967003869 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1114967003870 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1114967003871 Magnesium ion binding site [ion binding]; other site 1114967003872 Domain of unknown function (DUF929); Region: DUF929; pfam06053 1114967003873 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1114967003874 Thioesterase domain; Region: Thioesterase; pfam00975 1114967003875 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 1114967003876 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1114967003877 AMP binding site [chemical binding]; other site 1114967003878 active site 1114967003879 acyl-activating enzyme (AAE) consensus motif; other site 1114967003880 CoA binding site [chemical binding]; other site 1114967003881 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1114967003882 Condensation domain; Region: Condensation; pfam00668 1114967003883 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1114967003884 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1114967003885 2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944 1114967003886 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1114967003887 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 1114967003888 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1114967003889 dimer interface [polypeptide binding]; other site 1114967003890 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114967003891 catalytic residue [active] 1114967003892 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1114967003893 ParB-like nuclease domain; Region: ParBc; cl02129 1114967003894 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1114967003895 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 1114967003896 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1114967003897 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 1114967003898 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1114967003899 Ligand Binding Site [chemical binding]; other site 1114967003900 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 1114967003901 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1114967003902 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1114967003903 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 1114967003904 Protein of unknown function DUF45; Region: DUF45; pfam01863 1114967003905 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1114967003906 Part of AAA domain; Region: AAA_19; pfam13245 1114967003907 Family description; Region: UvrD_C_2; pfam13538 1114967003908 HRDC domain; Region: HRDC; pfam00570 1114967003909 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 1114967003910 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 1114967003911 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 1114967003912 Part of AAA domain; Region: AAA_19; pfam13245 1114967003913 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1114967003914 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 1114967003915 AAA domain; Region: AAA_30; pfam13604 1114967003916 Family description; Region: UvrD_C_2; pfam13538 1114967003917 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 1114967003918 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1114967003919 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1114967003920 putative NADH binding site [chemical binding]; other site 1114967003921 putative active site [active] 1114967003922 nudix motif; other site 1114967003923 putative metal binding site [ion binding]; other site 1114967003924 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1114967003925 Part of AAA domain; Region: AAA_19; pfam13245 1114967003926 Family description; Region: UvrD_C_2; pfam13538 1114967003927 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1114967003928 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1114967003929 Part of AAA domain; Region: AAA_19; pfam13245 1114967003930 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1114967003931 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1114967003932 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1114967003933 active site 1114967003934 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 1114967003935 tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like; Region: MiaE_2; pfam13794 1114967003936 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 1114967003937 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1114967003938 ATP binding site [chemical binding]; other site 1114967003939 Mg++ binding site [ion binding]; other site 1114967003940 motif III; other site 1114967003941 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1114967003942 nucleotide binding region [chemical binding]; other site 1114967003943 ATP-binding site [chemical binding]; other site 1114967003944 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1114967003945 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1114967003946 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1114967003947 active site 1114967003948 HIGH motif; other site 1114967003949 dimer interface [polypeptide binding]; other site 1114967003950 KMSKS motif; other site 1114967003951 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 1114967003952 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1114967003953 active site 1114967003954 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1114967003955 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 1114967003956 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 1114967003957 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1114967003958 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1114967003959 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1114967003960 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1114967003961 30S subunit binding site; other site 1114967003962 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1114967003963 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1114967003964 active site 1114967003965 Sporulation and spore germination; Region: Germane; cl11253 1114967003966 Lipoprotein LpqB beta-propeller domain; Region: Gmad1; pfam10647 1114967003967 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1114967003968 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114967003969 dimerization interface [polypeptide binding]; other site 1114967003970 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114967003971 dimer interface [polypeptide binding]; other site 1114967003972 phosphorylation site [posttranslational modification] 1114967003973 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114967003974 ATP binding site [chemical binding]; other site 1114967003975 Mg2+ binding site [ion binding]; other site 1114967003976 G-X-G motif; other site 1114967003977 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1114967003978 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114967003979 active site 1114967003980 phosphorylation site [posttranslational modification] 1114967003981 intermolecular recognition site; other site 1114967003982 dimerization interface [polypeptide binding]; other site 1114967003983 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1114967003984 DNA binding site [nucleotide binding] 1114967003985 hypothetical protein; Validated; Region: PRK00228 1114967003986 CAMP factor (Cfa); Region: CAMP_factor; pfam07373 1114967003987 ribbon-helix-helix domain containing protein; Region: PHA00617 1114967003988 Protein of unknown function (DUF1706); Region: DUF1706; cl01748 1114967003989 Protein of unknown function (DUF1706); Region: DUF1706; cl01748 1114967003990 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1114967003991 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1114967003992 Tic20-like protein; Region: Tic20; pfam09685 1114967003993 argininosuccinate lyase; Provisional; Region: PRK00855 1114967003994 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1114967003995 active sites [active] 1114967003996 tetramer interface [polypeptide binding]; other site 1114967003997 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 1114967003998 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1114967003999 inhibitor-cofactor binding pocket; inhibition site 1114967004000 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114967004001 catalytic residue [active] 1114967004002 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 1114967004003 feedback inhibition sensing region; other site 1114967004004 homohexameric interface [polypeptide binding]; other site 1114967004005 nucleotide binding site [chemical binding]; other site 1114967004006 N-acetyl-L-glutamate binding site [chemical binding]; other site 1114967004007 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1114967004008 heterotetramer interface [polypeptide binding]; other site 1114967004009 active site pocket [active] 1114967004010 cleavage site 1114967004011 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1114967004012 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1114967004013 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1114967004014 SmpB-tmRNA interface; other site 1114967004015 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1114967004016 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1114967004017 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1114967004018 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114967004019 Walker A/P-loop; other site 1114967004020 ATP binding site [chemical binding]; other site 1114967004021 Q-loop/lid; other site 1114967004022 ABC transporter signature motif; other site 1114967004023 Walker B; other site 1114967004024 D-loop; other site 1114967004025 H-loop/switch region; other site 1114967004026 peptide chain release factor 2; Validated; Region: prfB; PRK00578 1114967004027 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1114967004028 RF-1 domain; Region: RF-1; pfam00472 1114967004029 Protein of unknown function (DUF805); Region: DUF805; pfam05656 1114967004030 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1114967004031 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1114967004032 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1114967004033 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1114967004034 thiamine monophosphate kinase; Provisional; Region: PRK05731 1114967004035 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1114967004036 ATP binding site [chemical binding]; other site 1114967004037 dimerization interface [polypeptide binding]; other site 1114967004038 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 1114967004039 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1114967004040 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1114967004041 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1114967004042 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1114967004043 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1114967004044 putative acyl-acceptor binding pocket; other site 1114967004045 hypothetical protein; Provisional; Region: PRK14812 1114967004046 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1114967004047 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1114967004048 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1114967004049 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1114967004050 Bacterial transcriptional regulator; Region: IclR; pfam01614 1114967004051 CAAX protease self-immunity; Region: Abi; pfam02517 1114967004052 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 1114967004053 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1114967004054 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1114967004055 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 1114967004056 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1114967004057 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1114967004058 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 1114967004059 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1114967004060 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1114967004061 homodimer interface [polypeptide binding]; other site 1114967004062 substrate-cofactor binding pocket; other site 1114967004063 catalytic residue [active] 1114967004064 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 1114967004065 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 1114967004066 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1114967004067 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1114967004068 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1114967004069 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1114967004070 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1114967004071 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1114967004072 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1114967004073 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1114967004074 HIT family signature motif; other site 1114967004075 catalytic residue [active] 1114967004076 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1114967004077 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1114967004078 substrate binding site [chemical binding]; other site 1114967004079 glutamase interaction surface [polypeptide binding]; other site 1114967004080 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 1114967004081 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1114967004082 ATP binding site [chemical binding]; other site 1114967004083 putative Mg++ binding site [ion binding]; other site 1114967004084 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1114967004085 nucleotide binding region [chemical binding]; other site 1114967004086 ATP-binding site [chemical binding]; other site 1114967004087 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 1114967004088 Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902 1114967004089 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 1114967004090 Predicted transcriptional regulator [Transcription]; Region: COG2378 1114967004091 WYL domain; Region: WYL; pfam13280 1114967004092 Predicted transcriptional regulator [Transcription]; Region: COG2378 1114967004093 WYL domain; Region: WYL; pfam13280 1114967004094 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1114967004095 active site 1114967004096 HIGH motif; other site 1114967004097 nucleotide binding site [chemical binding]; other site 1114967004098 active site 1114967004099 KMSKS motif; other site 1114967004100 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1114967004101 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1114967004102 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1114967004103 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1114967004104 RNA binding surface [nucleotide binding]; other site 1114967004105 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1114967004106 active site 1114967004107 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1114967004108 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1114967004109 P-loop; other site 1114967004110 Magnesium ion binding site [ion binding]; other site 1114967004111 transport-energizing ATPase, TRC40/GET3/ArsA family; Region: GET3_arsA_TRC40; TIGR00345 1114967004112 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1114967004113 Magnesium ion binding site [ion binding]; other site 1114967004114 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1114967004115 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1114967004116 active site 1114967004117 Int/Topo IB signature motif; other site 1114967004118 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1114967004119 dimer interface [polypeptide binding]; other site 1114967004120 ADP-ribose binding site [chemical binding]; other site 1114967004121 active site 1114967004122 nudix motif; other site 1114967004123 metal binding site [ion binding]; metal-binding site 1114967004124 CTP synthetase; Validated; Region: pyrG; PRK05380 1114967004125 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1114967004126 Catalytic site [active] 1114967004127 active site 1114967004128 UTP binding site [chemical binding]; other site 1114967004129 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1114967004130 active site 1114967004131 putative oxyanion hole; other site 1114967004132 catalytic triad [active] 1114967004133 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1114967004134 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114967004135 Walker A/P-loop; other site 1114967004136 ATP binding site [chemical binding]; other site 1114967004137 Q-loop/lid; other site 1114967004138 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1114967004139 ABC transporter signature motif; other site 1114967004140 Walker B; other site 1114967004141 D-loop; other site 1114967004142 H-loop/switch region; other site 1114967004143 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 1114967004144 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1114967004145 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1114967004146 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1114967004147 RNA binding surface [nucleotide binding]; other site 1114967004148 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1114967004149 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1114967004150 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1114967004151 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1114967004152 Walker A/P-loop; other site 1114967004153 ATP binding site [chemical binding]; other site 1114967004154 Q-loop/lid; other site 1114967004155 ABC transporter signature motif; other site 1114967004156 Walker B; other site 1114967004157 D-loop; other site 1114967004158 H-loop/switch region; other site 1114967004159 BioY family; Region: BioY; pfam02632 1114967004160 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1114967004161 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114967004162 active site 1114967004163 motif I; other site 1114967004164 motif II; other site 1114967004165 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1114967004166 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1114967004167 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1114967004168 TPR motif; other site 1114967004169 binding surface 1114967004170 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1114967004171 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1114967004172 active site 1114967004173 HIGH motif; other site 1114967004174 dimer interface [polypeptide binding]; other site 1114967004175 KMSKS motif; other site 1114967004176 arginine repressor; Provisional; Region: PRK03341 1114967004177 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1114967004178 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1114967004179 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114967004180 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1114967004181 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1114967004182 biotin synthase; Validated; Region: PRK06256 1114967004183 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1114967004184 FeS/SAM binding site; other site 1114967004185 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1114967004186 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1114967004187 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1114967004188 putative tRNA-binding site [nucleotide binding]; other site 1114967004189 B3/4 domain; Region: B3_4; pfam03483 1114967004190 tRNA synthetase B5 domain; Region: B5; pfam03484 1114967004191 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1114967004192 dimer interface [polypeptide binding]; other site 1114967004193 motif 1; other site 1114967004194 motif 3; other site 1114967004195 motif 2; other site 1114967004196 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1114967004197 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1114967004198 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1114967004199 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1114967004200 dimer interface [polypeptide binding]; other site 1114967004201 motif 1; other site 1114967004202 active site 1114967004203 motif 2; other site 1114967004204 motif 3; other site 1114967004205 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1114967004206 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 1114967004207 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1114967004208 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1114967004209 23S rRNA binding site [nucleotide binding]; other site 1114967004210 L21 binding site [polypeptide binding]; other site 1114967004211 L13 binding site [polypeptide binding]; other site 1114967004212 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1114967004213 translation initiation factor IF-3; Region: infC; TIGR00168 1114967004214 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1114967004215 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1114967004216 Protein of unknown function (DUF418); Region: DUF418; cl12135 1114967004217 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 1114967004218 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 1114967004219 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 1114967004220 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 1114967004221 homodimer interface [polypeptide binding]; other site 1114967004222 putative metal binding site [ion binding]; other site 1114967004223 Nicotinamide mononucleotide transporter [Coenzyme metabolism]; Region: PnuC; COG3201 1114967004224 conserved hypothetical protein; Region: TIGR03843 1114967004225 conserved hypothetical protein; Region: TIGR03847 1114967004226 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1114967004227 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1114967004228 active site 1114967004229 catalytic tetrad [active] 1114967004230 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1114967004231 dimer interface [polypeptide binding]; other site 1114967004232 Citrate synthase; Region: Citrate_synt; pfam00285 1114967004233 active site 1114967004234 citrylCoA binding site [chemical binding]; other site 1114967004235 NADH binding [chemical binding]; other site 1114967004236 cationic pore residues; other site 1114967004237 oxalacetate/citrate binding site [chemical binding]; other site 1114967004238 coenzyme A binding site [chemical binding]; other site 1114967004239 catalytic triad [active] 1114967004240 hypothetical protein; Provisional; Region: PRK07906 1114967004241 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 1114967004242 putative metal binding site [ion binding]; other site 1114967004243 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1114967004244 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1114967004245 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1114967004246 CsbD-like; Region: CsbD; pfam05532 1114967004247 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1114967004248 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1114967004249 DNA binding site [nucleotide binding] 1114967004250 active site 1114967004251 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1114967004252 DNA protecting protein DprA; Region: dprA; TIGR00732 1114967004253 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1114967004254 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1114967004255 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114967004256 Walker A motif; other site 1114967004257 ATP binding site [chemical binding]; other site 1114967004258 Walker B motif; other site 1114967004259 arginine finger; other site 1114967004260 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1114967004261 hypothetical protein; Reviewed; Region: PRK12497 1114967004262 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 1114967004263 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1114967004264 RNA/DNA hybrid binding site [nucleotide binding]; other site 1114967004265 active site 1114967004266 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1114967004267 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1114967004268 Catalytic site [active] 1114967004269 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1114967004270 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 1114967004271 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1114967004272 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1114967004273 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 1114967004274 L-aspartate oxidase; Provisional; Region: PRK06175 1114967004275 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1114967004276 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 1114967004277 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 1114967004278 putative Iron-sulfur protein interface [polypeptide binding]; other site 1114967004279 proximal heme binding site [chemical binding]; other site 1114967004280 distal heme binding site [chemical binding]; other site 1114967004281 putative dimer interface [polypeptide binding]; other site 1114967004282 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1114967004283 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1114967004284 RimM N-terminal domain; Region: RimM; pfam01782 1114967004285 PRC-barrel domain; Region: PRC; pfam05239 1114967004286 hypothetical protein; Provisional; Region: PRK02821 1114967004287 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1114967004288 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 1114967004289 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1114967004290 Amidohydrolase; Region: Amidohydro_4; pfam13147 1114967004291 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1114967004292 active site 1114967004293 signal recognition particle protein; Provisional; Region: PRK10867 1114967004294 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1114967004295 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1114967004296 P loop; other site 1114967004297 GTP binding site [chemical binding]; other site 1114967004298 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1114967004299 Predicted esterase [General function prediction only]; Region: COG0627 1114967004300 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 1114967004301 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1114967004302 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1114967004303 P loop; other site 1114967004304 GTP binding site [chemical binding]; other site 1114967004305 Predicted membrane protein [Function unknown]; Region: COG2246 1114967004306 GtrA-like protein; Region: GtrA; pfam04138 1114967004307 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 1114967004308 HicB family; Region: HicB; pfam05534 1114967004309 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1114967004310 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1114967004311 DNA binding site [nucleotide binding] 1114967004312 catalytic residue [active] 1114967004313 H2TH interface [polypeptide binding]; other site 1114967004314 putative catalytic residues [active] 1114967004315 turnover-facilitating residue; other site 1114967004316 intercalation triad [nucleotide binding]; other site 1114967004317 8OG recognition residue [nucleotide binding]; other site 1114967004318 putative reading head residues; other site 1114967004319 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1114967004320 ribonuclease III; Reviewed; Region: rnc; PRK00102 1114967004321 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1114967004322 dimerization interface [polypeptide binding]; other site 1114967004323 active site 1114967004324 metal binding site [ion binding]; metal-binding site 1114967004325 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1114967004326 dsRNA binding site [nucleotide binding]; other site 1114967004327 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 1114967004328 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 1114967004329 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1114967004330 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1114967004331 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1114967004332 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114967004333 dimer interface [polypeptide binding]; other site 1114967004334 conserved gate region; other site 1114967004335 putative PBP binding loops; other site 1114967004336 ABC-ATPase subunit interface; other site 1114967004337 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1114967004338 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114967004339 dimer interface [polypeptide binding]; other site 1114967004340 conserved gate region; other site 1114967004341 putative PBP binding loops; other site 1114967004342 ABC-ATPase subunit interface; other site 1114967004343 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1114967004344 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1114967004345 DNA binding site [nucleotide binding] 1114967004346 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1114967004347 ligand binding site [chemical binding]; other site 1114967004348 dimerization interface [polypeptide binding]; other site 1114967004349 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 1114967004350 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 1114967004351 active site 1114967004352 catalytic site [active] 1114967004353 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; pfam09261 1114967004354 Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565 1114967004355 putative active site [active] 1114967004356 potential frameshift: common BLAST hit: gi|257069311|ref|YP_003155566.1| ABC-type dipeptide/oligopeptide/nickel transporter permease 1114967004357 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1114967004358 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114967004359 dimer interface [polypeptide binding]; other site 1114967004360 conserved gate region; other site 1114967004361 putative PBP binding loops; other site 1114967004362 ABC-ATPase subunit interface; other site 1114967004363 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1114967004364 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1114967004365 Walker A/P-loop; other site 1114967004366 ATP binding site [chemical binding]; other site 1114967004367 Q-loop/lid; other site 1114967004368 ABC transporter signature motif; other site 1114967004369 Walker B; other site 1114967004370 D-loop; other site 1114967004371 H-loop/switch region; other site 1114967004372 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1114967004373 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1114967004374 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1114967004375 Walker A/P-loop; other site 1114967004376 ATP binding site [chemical binding]; other site 1114967004377 Q-loop/lid; other site 1114967004378 ABC transporter signature motif; other site 1114967004379 Walker B; other site 1114967004380 D-loop; other site 1114967004381 H-loop/switch region; other site 1114967004382 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1114967004383 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1114967004384 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 1114967004385 substrate binding site [chemical binding]; other site 1114967004386 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 1114967004387 GH18 domain of CTS3 (chitinase 3), an uncharacterized protein from the human fungal pathogen Coccidioides posadasii. CTS3 has a chitinase-like glycosyl hydrolase family 18 (GH18) domain; and has homologs in bacteria as well as fungi; Region: GH18_CTS3_chitinase; cd06546 1114967004388 putative active site [active] 1114967004389 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114967004390 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114967004391 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1114967004392 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1114967004393 active site 1114967004394 (T/H)XGH motif; other site 1114967004395 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1114967004396 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114967004397 S-adenosylmethionine binding site [chemical binding]; other site 1114967004398 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 1114967004399 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1114967004400 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1114967004401 ssDNA binding site; other site 1114967004402 generic binding surface II; other site 1114967004403 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1114967004404 ATP binding site [chemical binding]; other site 1114967004405 putative Mg++ binding site [ion binding]; other site 1114967004406 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1114967004407 nucleotide binding region [chemical binding]; other site 1114967004408 ATP-binding site [chemical binding]; other site 1114967004409 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1114967004410 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1114967004411 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1114967004412 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1114967004413 pyruvate dehydrogenase; Provisional; Region: PRK06546 1114967004414 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1114967004415 PYR/PP interface [polypeptide binding]; other site 1114967004416 dimer interface [polypeptide binding]; other site 1114967004417 tetramer interface [polypeptide binding]; other site 1114967004418 TPP binding site [chemical binding]; other site 1114967004419 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1114967004420 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1114967004421 TPP-binding site [chemical binding]; other site 1114967004422 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1114967004423 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1114967004424 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1114967004425 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1114967004426 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 1114967004427 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 1114967004428 oligomer interface [polypeptide binding]; other site 1114967004429 RNA binding site [nucleotide binding]; other site 1114967004430 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1114967004431 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1114967004432 RNase E interface [polypeptide binding]; other site 1114967004433 trimer interface [polypeptide binding]; other site 1114967004434 active site 1114967004435 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1114967004436 putative nucleic acid binding region [nucleotide binding]; other site 1114967004437 G-X-X-G motif; other site 1114967004438 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1114967004439 RNA binding site [nucleotide binding]; other site 1114967004440 domain interface; other site 1114967004441 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1114967004442 16S/18S rRNA binding site [nucleotide binding]; other site 1114967004443 S13e-L30e interaction site [polypeptide binding]; other site 1114967004444 25S rRNA binding site [nucleotide binding]; other site 1114967004445 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1114967004446 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1114967004447 active site 1114967004448 Riboflavin kinase; Region: Flavokinase; smart00904 1114967004449 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1114967004450 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1114967004451 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 1114967004452 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114967004453 dimer interface [polypeptide binding]; other site 1114967004454 conserved gate region; other site 1114967004455 ABC-ATPase subunit interface; other site 1114967004456 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 1114967004457 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114967004458 Walker A/P-loop; other site 1114967004459 ATP binding site [chemical binding]; other site 1114967004460 Q-loop/lid; other site 1114967004461 ABC transporter signature motif; other site 1114967004462 Walker B; other site 1114967004463 D-loop; other site 1114967004464 H-loop/switch region; other site 1114967004465 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1114967004466 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 1114967004467 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1114967004468 RNA binding site [nucleotide binding]; other site 1114967004469 active site 1114967004470 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 1114967004471 Cupin domain; Region: Cupin_2; cl17218 1114967004472 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1114967004473 HTH domain; Region: HTH_11; pfam08279 1114967004474 HTH domain; Region: HTH_11; pfam08279 1114967004475 PRD domain; Region: PRD; pfam00874 1114967004476 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 1114967004477 active site 1114967004478 P-loop; other site 1114967004479 phosphorylation site [posttranslational modification] 1114967004480 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359 1114967004481 active site 1114967004482 phosphorylation site [posttranslational modification] 1114967004483 Glucitol operon activator protein (GutM); Region: GutM; pfam06923 1114967004484 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; pfam03608 1114967004485 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 1114967004486 PTS system, glucitol/sorbitol-specific, IIBC component; Region: EIIBC-GUT; TIGR00825 1114967004487 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 1114967004488 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829 1114967004489 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1114967004490 dimerization domain swap beta strand [polypeptide binding]; other site 1114967004491 regulatory protein interface [polypeptide binding]; other site 1114967004492 active site 1114967004493 regulatory phosphorylation site [posttranslational modification]; other site 1114967004494 Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175 1114967004495 active site 1114967004496 metal binding site [ion binding]; metal-binding site 1114967004497 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1114967004498 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1114967004499 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1114967004500 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 1114967004501 Walker A/P-loop; other site 1114967004502 ATP binding site [chemical binding]; other site 1114967004503 Q-loop/lid; other site 1114967004504 ABC transporter signature motif; other site 1114967004505 Walker B; other site 1114967004506 D-loop; other site 1114967004507 H-loop/switch region; other site 1114967004508 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1114967004509 translation initiation factor IF-2; Region: IF-2; TIGR00487 1114967004510 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1114967004511 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1114967004512 G1 box; other site 1114967004513 putative GEF interaction site [polypeptide binding]; other site 1114967004514 GTP/Mg2+ binding site [chemical binding]; other site 1114967004515 Switch I region; other site 1114967004516 G2 box; other site 1114967004517 G3 box; other site 1114967004518 Switch II region; other site 1114967004519 G4 box; other site 1114967004520 G5 box; other site 1114967004521 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1114967004522 Translation-initiation factor 2; Region: IF-2; pfam11987 1114967004523 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1114967004524 Protein of unknown function (DUF448); Region: DUF448; pfam04296 1114967004525 putative RNA binding cleft [nucleotide binding]; other site 1114967004526 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1114967004527 NusA N-terminal domain; Region: NusA_N; pfam08529 1114967004528 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1114967004529 RNA binding site [nucleotide binding]; other site 1114967004530 homodimer interface [polypeptide binding]; other site 1114967004531 NusA-like KH domain; Region: KH_5; pfam13184 1114967004532 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1114967004533 G-X-X-G motif; other site 1114967004534 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1114967004535 Sm and related proteins; Region: Sm_like; cl00259 1114967004536 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1114967004537 putative oligomer interface [polypeptide binding]; other site 1114967004538 putative RNA binding site [nucleotide binding]; other site 1114967004539 hypothetical protein; Provisional; Region: PRK10621 1114967004540 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1114967004541 metallophosphoesterase, PPA1498 family; Region: P_acnes_RR; TIGR03767 1114967004542 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1114967004543 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1114967004544 dimer interface [polypeptide binding]; other site 1114967004545 motif 1; other site 1114967004546 active site 1114967004547 motif 2; other site 1114967004548 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1114967004549 putative deacylase active site [active] 1114967004550 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1114967004551 active site 1114967004552 motif 3; other site 1114967004553 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1114967004554 anticodon binding site; other site 1114967004555 putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773 1114967004556 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 1114967004557 putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773 1114967004558 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 1114967004559 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 1114967004560 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1114967004561 anchored repeat ABC transporter, substrate-binding protein; Region: anch_rpt_subst; TIGR03772 1114967004562 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 1114967004563 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1114967004564 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 1114967004565 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1114967004566 anchored repeat-type ABC transporter, ATP-binding subunit; Region: anch_rpt_ABC; TIGR03771 1114967004567 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1114967004568 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1114967004569 ABC-ATPase subunit interface; other site 1114967004570 dimer interface [polypeptide binding]; other site 1114967004571 putative PBP binding regions; other site 1114967004572 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 1114967004573 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1114967004574 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1114967004575 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1114967004576 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1114967004577 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 1114967004578 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1114967004579 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 1114967004580 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1114967004581 active site 1114967004582 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1114967004583 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1114967004584 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1114967004585 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1114967004586 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1114967004587 Beta-lactamase; Region: Beta-lactamase; pfam00144 1114967004588 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1114967004589 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1114967004590 glutamate dehydrogenase; Provisional; Region: PRK09414 1114967004591 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1114967004592 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 1114967004593 NAD(P) binding site [chemical binding]; other site 1114967004594 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 1114967004595 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1114967004596 FeS/SAM binding site; other site 1114967004597 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 1114967004598 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1114967004599 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1114967004600 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1114967004601 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1114967004602 hinge region; other site 1114967004603 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1114967004604 putative nucleotide binding site [chemical binding]; other site 1114967004605 uridine monophosphate binding site [chemical binding]; other site 1114967004606 homohexameric interface [polypeptide binding]; other site 1114967004607 elongation factor Ts; Provisional; Region: tsf; PRK09377 1114967004608 UBA/TS-N domain; Region: UBA; pfam00627 1114967004609 Elongation factor TS; Region: EF_TS; pfam00889 1114967004610 Elongation factor TS; Region: EF_TS; pfam00889 1114967004611 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1114967004612 rRNA interaction site [nucleotide binding]; other site 1114967004613 S8 interaction site; other site 1114967004614 putative laminin-1 binding site; other site 1114967004615 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1114967004616 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1114967004617 active site 1114967004618 DNA binding site [nucleotide binding] 1114967004619 Int/Topo IB signature motif; other site 1114967004620 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 1114967004621 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1114967004622 active site 1114967004623 catalytic residues [active] 1114967004624 metal binding site [ion binding]; metal-binding site 1114967004625 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1114967004626 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1114967004627 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1114967004628 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 1114967004629 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1114967004630 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1114967004631 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 1114967004632 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1114967004633 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114967004634 Walker A/P-loop; other site 1114967004635 ATP binding site [chemical binding]; other site 1114967004636 Q-loop/lid; other site 1114967004637 ABC transporter signature motif; other site 1114967004638 Walker B; other site 1114967004639 D-loop; other site 1114967004640 H-loop/switch region; other site 1114967004641 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 1114967004642 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114967004643 NAD(P) binding site [chemical binding]; other site 1114967004644 active site 1114967004645 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114967004646 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1114967004647 NAD(P) binding site [chemical binding]; other site 1114967004648 active site 1114967004649 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 1114967004650 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 1114967004651 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 1114967004652 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114967004653 S-adenosylmethionine binding site [chemical binding]; other site 1114967004654 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1114967004655 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114967004656 Walker A/P-loop; other site 1114967004657 ATP binding site [chemical binding]; other site 1114967004658 Q-loop/lid; other site 1114967004659 ABC transporter signature motif; other site 1114967004660 Walker B; other site 1114967004661 D-loop; other site 1114967004662 H-loop/switch region; other site 1114967004663 ABC transporter; Region: ABC_tran_2; pfam12848 1114967004664 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1114967004665 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114967004666 Coenzyme A binding pocket [chemical binding]; other site 1114967004667 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1114967004668 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1114967004669 phosphate binding site [ion binding]; other site 1114967004670 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1114967004671 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1114967004672 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1114967004673 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1114967004674 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1114967004675 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1114967004676 trimerization site [polypeptide binding]; other site 1114967004677 active site 1114967004678 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1114967004679 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1114967004680 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1114967004681 catalytic residue [active] 1114967004682 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1114967004683 FeS assembly ATPase SufC; Region: sufC; TIGR01978 1114967004684 Walker A/P-loop; other site 1114967004685 ATP binding site [chemical binding]; other site 1114967004686 Q-loop/lid; other site 1114967004687 ABC transporter signature motif; other site 1114967004688 Walker B; other site 1114967004689 D-loop; other site 1114967004690 H-loop/switch region; other site 1114967004691 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 1114967004692 [2Fe-2S] cluster binding site [ion binding]; other site 1114967004693 FeS assembly protein SufD; Region: sufD; TIGR01981 1114967004694 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 1114967004695 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1114967004696 FeS assembly protein SufB; Region: sufB; TIGR01980 1114967004697 Predicted transcriptional regulator [Transcription]; Region: COG2345 1114967004698 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1114967004699 dimerization interface [polypeptide binding]; other site 1114967004700 putative DNA binding site [nucleotide binding]; other site 1114967004701 putative Zn2+ binding site [ion binding]; other site 1114967004702 potential frameshift: common BLAST hit: gi|295131101|ref|YP_003581764.1| bacterial extracellular solute-binding protein 1114967004703 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114967004704 dimer interface [polypeptide binding]; other site 1114967004705 conserved gate region; other site 1114967004706 putative PBP binding loops; other site 1114967004707 ABC-ATPase subunit interface; other site 1114967004708 potential frameshift: common BLAST hit: gi|295131103|ref|YP_003581766.1| putative type IV conjugative transfer system protein TraL 1114967004709 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1114967004710 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1114967004711 DNA binding site [nucleotide binding] 1114967004712 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_10; cd06292 1114967004713 putative dimerization interface [polypeptide binding]; other site 1114967004714 putative ligand binding site [chemical binding]; other site 1114967004715 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 1114967004716 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 1114967004717 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1114967004718 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1114967004719 Walker A/P-loop; other site 1114967004720 ATP binding site [chemical binding]; other site 1114967004721 Q-loop/lid; other site 1114967004722 ABC transporter signature motif; other site 1114967004723 Walker B; other site 1114967004724 D-loop; other site 1114967004725 H-loop/switch region; other site 1114967004726 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1114967004727 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1114967004728 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1114967004729 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1114967004730 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 1114967004731 catalytic site [active] 1114967004732 BNR repeat-like domain; Region: BNR_2; pfam13088 1114967004733 Asp-box motif; other site 1114967004734 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1114967004735 UbiA prenyltransferase family; Region: UbiA; pfam01040 1114967004736 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1114967004737 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1114967004738 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1114967004739 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 1114967004740 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 1114967004741 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1114967004742 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 1114967004743 putative active site [active] 1114967004744 DoxX; Region: DoxX; pfam07681 1114967004745 Thioredoxin; Region: Thioredoxin_4; cl17273 1114967004746 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1114967004747 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208 1114967004748 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1114967004749 active site 1114967004750 HIGH motif; other site 1114967004751 nucleotide binding site [chemical binding]; other site 1114967004752 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1114967004753 active site 1114967004754 KMSKS motif; other site 1114967004755 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1114967004756 tRNA binding surface [nucleotide binding]; other site 1114967004757 anticodon binding site; other site 1114967004758 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1114967004759 Endo-alpha-N-acetylgalactosaminidase; Region: Glyco_hydro_101; pfam12905 1114967004760 Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown]; Region: COG4946 1114967004761 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1114967004762 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1114967004763 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 1114967004764 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1114967004765 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1114967004766 protein binding site [polypeptide binding]; other site 1114967004767 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 1114967004768 Domain interface; other site 1114967004769 Peptide binding site; other site 1114967004770 Active site tetrad [active] 1114967004771 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1114967004772 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1114967004773 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114967004774 Walker A motif; other site 1114967004775 ATP binding site [chemical binding]; other site 1114967004776 Walker B motif; other site 1114967004777 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1114967004778 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 1114967004779 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1114967004780 oligomer interface [polypeptide binding]; other site 1114967004781 active site residues [active] 1114967004782 Clp protease; Region: CLP_protease; pfam00574 1114967004783 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1114967004784 oligomer interface [polypeptide binding]; other site 1114967004785 active site residues [active] 1114967004786 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1114967004787 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1114967004788 trigger factor; Provisional; Region: tig; PRK01490 1114967004789 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1114967004790 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1114967004791 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 1114967004792 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1114967004793 ATP binding site [chemical binding]; other site 1114967004794 putative Mg++ binding site [ion binding]; other site 1114967004795 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 1114967004796 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1114967004797 nucleotide binding region [chemical binding]; other site 1114967004798 ATP-binding site [chemical binding]; other site 1114967004799 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 1114967004800 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1114967004801 ATP binding site [chemical binding]; other site 1114967004802 putative Mg++ binding site [ion binding]; other site 1114967004803 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1114967004804 ATP-binding site [chemical binding]; other site 1114967004805 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1114967004806 Part of AAA domain; Region: AAA_19; pfam13245 1114967004807 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1114967004808 Family description; Region: UvrD_C_2; pfam13538 1114967004809 The HIRAN protein (HIP116, Rad5p N-terminal) is found in the N-terminal regions of the SWI2/SNF2 proteins typified by HIP116 and Rad5p; Region: HIRAN; smart00910 1114967004810 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1114967004811 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 1114967004812 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1114967004813 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1114967004814 dimer interface [polypeptide binding]; other site 1114967004815 putative anticodon binding site; other site 1114967004816 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1114967004817 motif 1; other site 1114967004818 dimer interface [polypeptide binding]; other site 1114967004819 active site 1114967004820 motif 2; other site 1114967004821 motif 3; other site 1114967004822 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1114967004823 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 1114967004824 putative DNA binding site [nucleotide binding]; other site 1114967004825 catalytic residue [active] 1114967004826 putative H2TH interface [polypeptide binding]; other site 1114967004827 putative catalytic residues [active] 1114967004828 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1114967004829 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1114967004830 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 1114967004831 hypothetical protein; Provisional; Region: PRK01346 1114967004832 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1114967004833 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1114967004834 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1114967004835 nucleotide binding pocket [chemical binding]; other site 1114967004836 K-X-D-G motif; other site 1114967004837 catalytic site [active] 1114967004838 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1114967004839 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1114967004840 Helix-hairpin-helix motif; Region: HHH; pfam00633 1114967004841 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1114967004842 Dimer interface [polypeptide binding]; other site 1114967004843 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 1114967004844 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 1114967004845 Zn binding site [ion binding]; other site 1114967004846 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1114967004847 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1114967004848 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1114967004849 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1114967004850 active site 1114967004851 catalytic site [active] 1114967004852 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1114967004853 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1114967004854 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1114967004855 active site 1114967004856 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1114967004857 active site 1114967004858 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1114967004859 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1114967004860 acyl-activating enzyme (AAE) consensus motif; other site 1114967004861 putative AMP binding site [chemical binding]; other site 1114967004862 putative active site [active] 1114967004863 putative CoA binding site [chemical binding]; other site 1114967004864 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1114967004865 MarR family; Region: MarR_2; pfam12802 1114967004866 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1114967004867 FAD binding domain; Region: FAD_binding_4; pfam01565 1114967004868 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1114967004869 Predicted transcriptional regulators [Transcription]; Region: COG1695 1114967004870 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1114967004871 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1114967004872 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114967004873 Walker A/P-loop; other site 1114967004874 ATP binding site [chemical binding]; other site 1114967004875 Q-loop/lid; other site 1114967004876 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1114967004877 ABC transporter; Region: ABC_tran_2; pfam12848 1114967004878 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1114967004879 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1114967004880 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1114967004881 dimer interface [polypeptide binding]; other site 1114967004882 ssDNA binding site [nucleotide binding]; other site 1114967004883 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1114967004884 YfjP GTPase; Region: YfjP; cd11383 1114967004885 G1 box; other site 1114967004886 GTP/Mg2+ binding site [chemical binding]; other site 1114967004887 Switch I region; other site 1114967004888 G2 box; other site 1114967004889 Switch II region; other site 1114967004890 G3 box; other site 1114967004891 G4 box; other site 1114967004892 G5 box; other site 1114967004893 Dynamin family; Region: Dynamin_N; pfam00350 1114967004894 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1114967004895 G1 box; other site 1114967004896 GTP/Mg2+ binding site [chemical binding]; other site 1114967004897 G2 box; other site 1114967004898 Switch I region; other site 1114967004899 Protease prsW family; Region: PrsW-protease; pfam13367 1114967004900 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114967004901 putative substrate translocation pore; other site 1114967004902 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114967004903 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1114967004904 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1114967004905 catalytic site [active] 1114967004906 putative active site [active] 1114967004907 putative substrate binding site [chemical binding]; other site 1114967004908 dimer interface [polypeptide binding]; other site 1114967004909 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1114967004910 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1114967004911 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1114967004912 active site 1114967004913 ATP binding site [chemical binding]; other site 1114967004914 substrate binding site [chemical binding]; other site 1114967004915 activation loop (A-loop); other site 1114967004916 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1114967004917 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1114967004918 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 1114967004919 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1114967004920 active site 1114967004921 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1114967004922 generic binding surface I; other site 1114967004923 generic binding surface II; other site 1114967004924 DNA Polymerase Y-family; Region: PolY_like; cd03468 1114967004925 active site 1114967004926 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 1114967004927 DNA binding site [nucleotide binding] 1114967004928 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 1114967004929 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 1114967004930 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1114967004931 catalytic triad [active] 1114967004932 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1114967004933 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1114967004934 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114967004935 dimer interface [polypeptide binding]; other site 1114967004936 conserved gate region; other site 1114967004937 putative PBP binding loops; other site 1114967004938 ABC-ATPase subunit interface; other site 1114967004939 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1114967004940 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114967004941 dimer interface [polypeptide binding]; other site 1114967004942 conserved gate region; other site 1114967004943 putative PBP binding loops; other site 1114967004944 ABC-ATPase subunit interface; other site 1114967004945 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 1114967004946 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1114967004947 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1114967004948 catalytic triad [active] 1114967004949 CH-type (Chalaropsis-type) lysozymes represent one of four functionally-defined classes of peptidoglycan hydrolases (also referred to as endo-N-acetylmuramidases) that cleave bacterial cell wall peptidoglycans. CH-type lysozymes exhibit both lysozyme; Region: GH25_CH-type; cd06412 1114967004950 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1114967004951 active site 1114967004952 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 1114967004953 active site 1114967004954 catalytic triad [active] 1114967004955 oxyanion hole [active] 1114967004956 Thrombospondin type 3 repeat; Region: TSP_3; pfam02412 1114967004957 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 1114967004958 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1114967004959 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1114967004960 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1114967004961 putative active site [active] 1114967004962 potential frameshift: common BLAST hit: gi|50843132|ref|YP_056359.1| membrane-spanning protein 1114967004963 DNA polymerase IV; Provisional; Region: PRK03348 1114967004964 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1114967004965 active site 1114967004966 DNA binding site [nucleotide binding] 1114967004967 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1114967004968 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1114967004969 folate binding site [chemical binding]; other site 1114967004970 NADP+ binding site [chemical binding]; other site 1114967004971 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1114967004972 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1114967004973 dimerization interface [polypeptide binding]; other site 1114967004974 active site 1114967004975 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1114967004976 active site 1114967004977 dimerization interface [polypeptide binding]; other site 1114967004978 ribonuclease PH; Reviewed; Region: rph; PRK00173 1114967004979 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1114967004980 hexamer interface [polypeptide binding]; other site 1114967004981 active site 1114967004982 glutamate racemase; Provisional; Region: PRK00865 1114967004983 FeoA domain; Region: FeoA; pfam04023 1114967004984 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 1114967004985 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1114967004986 G1 box; other site 1114967004987 GTP/Mg2+ binding site [chemical binding]; other site 1114967004988 Switch I region; other site 1114967004989 G2 box; other site 1114967004990 G3 box; other site 1114967004991 Switch II region; other site 1114967004992 G4 box; other site 1114967004993 G5 box; other site 1114967004994 Nucleoside recognition; Region: Gate; pfam07670 1114967004995 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1114967004996 Nucleoside recognition; Region: Gate; pfam07670 1114967004997 NifU-like domain; Region: NifU; cl00484 1114967004998 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 1114967004999 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 1114967005000 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1114967005001 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1114967005002 active site 1114967005003 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1114967005004 IHF dimer interface [polypeptide binding]; other site 1114967005005 IHF - DNA interface [nucleotide binding]; other site 1114967005006 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 1114967005007 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 1114967005008 RDD family; Region: RDD; pfam06271 1114967005009 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 1114967005010 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1114967005011 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1114967005012 trimer interface [polypeptide binding]; other site 1114967005013 active site 1114967005014 dimer interface [polypeptide binding]; other site 1114967005015 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1114967005016 Cation efflux family; Region: Cation_efflux; pfam01545 1114967005017 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1114967005018 Trm112p-like protein; Region: Trm112p; cl01066 1114967005019 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 1114967005020 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 1114967005021 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit [DNA replication, recombination, and repair]; Region: GyrA; COG0188 1114967005022 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1114967005023 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1114967005024 active site 1114967005025 Transcription factor WhiB; Region: Whib; pfam02467 1114967005026 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1114967005027 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 1114967005028 Substrate binding site; other site 1114967005029 TIGR03089 family protein; Region: TIGR03089 1114967005030 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1114967005031 ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525 1114967005032 Ligand binding site; other site 1114967005033 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 1114967005034 potential frameshift: common BLAST hit: gi|50843162|ref|YP_056389.1| beta-galactosidase 1114967005035 AIR carboxylase; Region: AIRC; pfam00731 1114967005036 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1114967005037 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1114967005038 NAD binding site [chemical binding]; other site 1114967005039 ATP-grasp domain; Region: ATP-grasp; pfam02222 1114967005040 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 1114967005041 active site pocket [active] 1114967005042 oxyanion hole [active] 1114967005043 catalytic triad [active] 1114967005044 active site nucleophile [active] 1114967005045 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1114967005046 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1114967005047 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1114967005048 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1114967005049 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1114967005050 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 1114967005051 Maf-like protein; Region: Maf; pfam02545 1114967005052 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1114967005053 active site 1114967005054 dimer interface [polypeptide binding]; other site 1114967005055 short chain dehydrogenase; Provisional; Region: PRK08219 1114967005056 classical (c) SDRs; Region: SDR_c; cd05233 1114967005057 NAD(P) binding site [chemical binding]; other site 1114967005058 active site 1114967005059 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1114967005060 dimer interface [polypeptide binding]; other site 1114967005061 substrate binding site [chemical binding]; other site 1114967005062 ATP binding site [chemical binding]; other site 1114967005063 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1114967005064 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1114967005065 Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158 1114967005066 TQXA domain; Region: TQXA_dom; TIGR03934 1114967005067 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 1114967005068 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 1114967005069 oligomer interface [polypeptide binding]; other site 1114967005070 metal binding site [ion binding]; metal-binding site 1114967005071 metal binding site [ion binding]; metal-binding site 1114967005072 putative Cl binding site [ion binding]; other site 1114967005073 aspartate ring; other site 1114967005074 basic sphincter; other site 1114967005075 hydrophobic gate; other site 1114967005076 periplasmic entrance; other site 1114967005077 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1114967005078 nudix motif; other site 1114967005079 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1114967005080 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1114967005081 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1114967005082 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1114967005083 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1114967005084 carboxyltransferase (CT) interaction site; other site 1114967005085 biotinylation site [posttranslational modification]; other site 1114967005086 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 1114967005087 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1114967005088 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1114967005089 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1114967005090 purine nucleoside phosphorylase; Provisional; Region: PRK08202 1114967005091 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 1114967005092 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1114967005093 active site 1114967005094 substrate binding site [chemical binding]; other site 1114967005095 metal binding site [ion binding]; metal-binding site 1114967005096 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1114967005097 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1114967005098 acyl-activating enzyme (AAE) consensus motif; other site 1114967005099 AMP binding site [chemical binding]; other site 1114967005100 active site 1114967005101 CoA binding site [chemical binding]; other site 1114967005102 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1114967005103 active site 1114967005104 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114967005105 putative substrate translocation pore; other site 1114967005106 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 1114967005107 active site 1114967005108 catalytic site [active] 1114967005109 substrate binding site [chemical binding]; other site 1114967005110 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 1114967005111 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1114967005112 active site 1114967005113 HIGH motif; other site 1114967005114 KMSKS motif; other site 1114967005115 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1114967005116 tRNA binding surface [nucleotide binding]; other site 1114967005117 anticodon binding site; other site 1114967005118 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1114967005119 RNA/DNA hybrid binding site [nucleotide binding]; other site 1114967005120 active site 1114967005121 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1114967005122 active site 1114967005123 catalytic motif [active] 1114967005124 Zn binding site [ion binding]; other site 1114967005125 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1114967005126 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1114967005127 TM-ABC transporter signature motif; other site 1114967005128 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1114967005129 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1114967005130 TM-ABC transporter signature motif; other site 1114967005131 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1114967005132 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1114967005133 Walker A/P-loop; other site 1114967005134 ATP binding site [chemical binding]; other site 1114967005135 Q-loop/lid; other site 1114967005136 ABC transporter signature motif; other site 1114967005137 Walker B; other site 1114967005138 D-loop; other site 1114967005139 H-loop/switch region; other site 1114967005140 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1114967005141 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1114967005142 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 1114967005143 ligand binding site [chemical binding]; other site 1114967005144 Phosphotransferase enzyme family; Region: APH; pfam01636 1114967005145 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1114967005146 Domain of unknown function DUF21; Region: DUF21; pfam01595 1114967005147 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1114967005148 Transporter associated domain; Region: CorC_HlyC; smart01091 1114967005149 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 1114967005150 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 1114967005151 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1114967005152 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1114967005153 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 1114967005154 active site 1114967005155 substrate binding site [chemical binding]; other site 1114967005156 cosubstrate binding site; other site 1114967005157 catalytic site [active] 1114967005158 malate dehydrogenase; Provisional; Region: PRK05442 1114967005159 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 1114967005160 NAD(P) binding site [chemical binding]; other site 1114967005161 dimer interface [polypeptide binding]; other site 1114967005162 malate binding site [chemical binding]; other site 1114967005163 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 1114967005164 putative catalytic cysteine [active] 1114967005165 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 1114967005166 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 1114967005167 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1114967005168 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1114967005169 homodimer interface [polypeptide binding]; other site 1114967005170 NADP binding site [chemical binding]; other site 1114967005171 substrate binding site [chemical binding]; other site 1114967005172 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1114967005173 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1114967005174 catalytic residue [active] 1114967005175 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1114967005176 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1114967005177 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1114967005178 purine monophosphate binding site [chemical binding]; other site 1114967005179 dimer interface [polypeptide binding]; other site 1114967005180 putative catalytic residues [active] 1114967005181 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1114967005182 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1114967005183 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1114967005184 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1114967005185 active site 1114967005186 cosubstrate binding site; other site 1114967005187 substrate binding site [chemical binding]; other site 1114967005188 catalytic site [active] 1114967005189 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1114967005190 homopentamer interface [polypeptide binding]; other site 1114967005191 active site 1114967005192 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1114967005193 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1114967005194 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1114967005195 dimerization interface [polypeptide binding]; other site 1114967005196 active site 1114967005197 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1114967005198 Lumazine binding domain; Region: Lum_binding; pfam00677 1114967005199 Lumazine binding domain; Region: Lum_binding; pfam00677 1114967005200 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1114967005201 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1114967005202 catalytic motif [active] 1114967005203 Zn binding site [ion binding]; other site 1114967005204 RibD C-terminal domain; Region: RibD_C; cl17279 1114967005205 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1114967005206 CoA binding domain; Region: CoA_binding; smart00881 1114967005207 CoA-ligase; Region: Ligase_CoA; pfam00549 1114967005208 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1114967005209 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1114967005210 CoA-ligase; Region: Ligase_CoA; pfam00549 1114967005211 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1114967005212 Part of AAA domain; Region: AAA_19; pfam13245 1114967005213 Family description; Region: UvrD_C_2; pfam13538 1114967005214 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1114967005215 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 1114967005216 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1114967005217 Walker A/P-loop; other site 1114967005218 ATP binding site [chemical binding]; other site 1114967005219 Q-loop/lid; other site 1114967005220 ABC transporter signature motif; other site 1114967005221 Walker B; other site 1114967005222 D-loop; other site 1114967005223 H-loop/switch region; other site 1114967005224 NIL domain; Region: NIL; pfam09383 1114967005225 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114967005226 ABC-ATPase subunit interface; other site 1114967005227 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1114967005228 PLD-like domain; Region: PLDc_2; pfam13091 1114967005229 putative active site [active] 1114967005230 catalytic site [active] 1114967005231 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1114967005232 PLD-like domain; Region: PLDc_2; pfam13091 1114967005233 putative active site [active] 1114967005234 catalytic site [active] 1114967005235 PspC domain; Region: PspC; pfam04024 1114967005236 GMP synthase; Reviewed; Region: guaA; PRK00074 1114967005237 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1114967005238 AMP/PPi binding site [chemical binding]; other site 1114967005239 candidate oxyanion hole; other site 1114967005240 catalytic triad [active] 1114967005241 potential glutamine specificity residues [chemical binding]; other site 1114967005242 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1114967005243 ATP Binding subdomain [chemical binding]; other site 1114967005244 Ligand Binding sites [chemical binding]; other site 1114967005245 Dimerization subdomain; other site 1114967005246 serine O-acetyltransferase; Region: cysE; TIGR01172 1114967005247 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1114967005248 trimer interface [polypeptide binding]; other site 1114967005249 active site 1114967005250 substrate binding site [chemical binding]; other site 1114967005251 CoA binding site [chemical binding]; other site 1114967005252 chorismate mutase; Provisional; Region: PRK09239 1114967005253 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 1114967005254 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1114967005255 phosphate binding site [ion binding]; other site 1114967005256 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1114967005257 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1114967005258 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1114967005259 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1114967005260 active site 1114967005261 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 1114967005262 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 1114967005263 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1114967005264 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1114967005265 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1114967005266 ring oligomerisation interface [polypeptide binding]; other site 1114967005267 ATP/Mg binding site [chemical binding]; other site 1114967005268 stacking interactions; other site 1114967005269 hinge regions; other site 1114967005270 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1114967005271 oligomerisation interface [polypeptide binding]; other site 1114967005272 mobile loop; other site 1114967005273 roof hairpin; other site 1114967005274 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1114967005275 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1114967005276 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1114967005277 Walker A/P-loop; other site 1114967005278 ATP binding site [chemical binding]; other site 1114967005279 Q-loop/lid; other site 1114967005280 ABC transporter signature motif; other site 1114967005281 Walker B; other site 1114967005282 D-loop; other site 1114967005283 H-loop/switch region; other site 1114967005284 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1114967005285 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1114967005286 ABC-ATPase subunit interface; other site 1114967005287 dimer interface [polypeptide binding]; other site 1114967005288 putative PBP binding regions; other site 1114967005289 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 1114967005290 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1114967005291 intersubunit interface [polypeptide binding]; other site 1114967005292 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 1114967005293 putative active site [active] 1114967005294 nucleotide binding site [chemical binding]; other site 1114967005295 nudix motif; other site 1114967005296 putative metal binding site [ion binding]; other site 1114967005297 UGMP family protein; Validated; Region: PRK09604 1114967005298 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 1114967005299 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1114967005300 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114967005301 Coenzyme A binding pocket [chemical binding]; other site 1114967005302 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1114967005303 Glycoprotease family; Region: Peptidase_M22; pfam00814 1114967005304 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1114967005305 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1114967005306 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1114967005307 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1114967005308 ATP binding site [chemical binding]; other site 1114967005309 Mg++ binding site [ion binding]; other site 1114967005310 motif III; other site 1114967005311 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1114967005312 nucleotide binding region [chemical binding]; other site 1114967005313 ATP-binding site [chemical binding]; other site 1114967005314 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1114967005315 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1114967005316 Walker A/P-loop; other site 1114967005317 ATP binding site [chemical binding]; other site 1114967005318 Q-loop/lid; other site 1114967005319 ABC transporter signature motif; other site 1114967005320 Walker B; other site 1114967005321 D-loop; other site 1114967005322 H-loop/switch region; other site 1114967005323 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1114967005324 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1114967005325 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 1114967005326 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1114967005327 putative substrate binding site [chemical binding]; other site 1114967005328 putative ATP binding site [chemical binding]; other site 1114967005329 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1114967005330 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1114967005331 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1114967005332 glutaminase active site [active] 1114967005333 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1114967005334 dimer interface [polypeptide binding]; other site 1114967005335 active site 1114967005336 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1114967005337 dimer interface [polypeptide binding]; other site 1114967005338 active site 1114967005339 Lipase (class 2); Region: Lipase_2; pfam01674 1114967005340 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1114967005341 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1114967005342 Lipase (class 2); Region: Lipase_2; pfam01674 1114967005343 pantothenate kinase; Provisional; Region: PRK05439 1114967005344 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1114967005345 ATP-binding site [chemical binding]; other site 1114967005346 CoA-binding site [chemical binding]; other site 1114967005347 Mg2+-binding site [ion binding]; other site 1114967005348 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 1114967005349 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1114967005350 active site 1114967005351 substrate binding site [chemical binding]; other site 1114967005352 metal binding site [ion binding]; metal-binding site 1114967005353 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1114967005354 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1114967005355 23S rRNA interface [nucleotide binding]; other site 1114967005356 L3 interface [polypeptide binding]; other site 1114967005357 Endo-beta-N-acetylglucosaminidase D [Carbohydrate transport and metabolism]; Region: COG4724 1114967005358 Glycosyl hydrolase family 85; Region: Glyco_hydro_85; pfam03644 1114967005359 active site 1114967005360 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114967005361 S-adenosylmethionine binding site [chemical binding]; other site 1114967005362 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1114967005363 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1114967005364 dimerization interface 3.5A [polypeptide binding]; other site 1114967005365 active site 1114967005366 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114967005367 S-adenosylmethionine binding site [chemical binding]; other site 1114967005368 Cobalt transport protein; Region: CbiQ; cl00463 1114967005369 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1114967005370 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1114967005371 Walker A/P-loop; other site 1114967005372 ATP binding site [chemical binding]; other site 1114967005373 Q-loop/lid; other site 1114967005374 ABC transporter signature motif; other site 1114967005375 Walker B; other site 1114967005376 D-loop; other site 1114967005377 H-loop/switch region; other site 1114967005378 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1114967005379 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114967005380 Walker A/P-loop; other site 1114967005381 ATP binding site [chemical binding]; other site 1114967005382 Q-loop/lid; other site 1114967005383 ABC transporter signature motif; other site 1114967005384 Walker B; other site 1114967005385 D-loop; other site 1114967005386 H-loop/switch region; other site 1114967005387 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 1114967005388 classical (c) SDRs; Region: SDR_c; cd05233 1114967005389 NAD(P) binding site [chemical binding]; other site 1114967005390 active site 1114967005391 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 1114967005392 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1114967005393 Walker A/P-loop; other site 1114967005394 ATP binding site [chemical binding]; other site 1114967005395 Q-loop/lid; other site 1114967005396 ABC transporter signature motif; other site 1114967005397 Walker B; other site 1114967005398 D-loop; other site 1114967005399 H-loop/switch region; other site 1114967005400 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1114967005401 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1114967005402 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1114967005403 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 1114967005404 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 1114967005405 Beta-galactosidase, domain 2; Region: BetaGal_dom2; smart01029 1114967005406 Beta-galactosidase, domain 2; Region: BetaGal_dom2; pfam10435 1114967005407 Beta-galactosidase jelly roll domain; Region: BetaGal_dom4_5; pfam13364 1114967005408 Beta-galactosidase jelly roll domain; Region: BetaGal_dom4_5; pfam13364 1114967005409 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 1114967005410 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 1114967005411 active site 1114967005412 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1114967005413 sugar binding site [chemical binding]; other site 1114967005414 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114967005415 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114967005416 putative substrate translocation pore; other site 1114967005417 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1114967005418 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1114967005419 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1114967005420 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1114967005421 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1114967005422 alphaNTD homodimer interface [polypeptide binding]; other site 1114967005423 alphaNTD - beta interaction site [polypeptide binding]; other site 1114967005424 alphaNTD - beta' interaction site [polypeptide binding]; other site 1114967005425 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1114967005426 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1114967005427 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1114967005428 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1114967005429 RNA binding surface [nucleotide binding]; other site 1114967005430 30S ribosomal protein S11; Validated; Region: PRK05309 1114967005431 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1114967005432 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1114967005433 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 1114967005434 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1114967005435 rRNA binding site [nucleotide binding]; other site 1114967005436 predicted 30S ribosome binding site; other site 1114967005437 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1114967005438 active site 1114967005439 adenylate kinase; Reviewed; Region: adk; PRK00279 1114967005440 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1114967005441 AMP-binding site [chemical binding]; other site 1114967005442 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1114967005443 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1114967005444 SecY translocase; Region: SecY; pfam00344 1114967005445 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114967005446 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114967005447 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 1114967005448 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 1114967005449 putative active site [active] 1114967005450 putative metal binding site [ion binding]; other site 1114967005451 catalytic site [active] 1114967005452 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1114967005453 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 1114967005454 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1114967005455 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1114967005456 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1114967005457 23S rRNA binding site [nucleotide binding]; other site 1114967005458 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1114967005459 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1114967005460 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1114967005461 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1114967005462 23S rRNA interface [nucleotide binding]; other site 1114967005463 5S rRNA interface [nucleotide binding]; other site 1114967005464 L27 interface [polypeptide binding]; other site 1114967005465 L5 interface [polypeptide binding]; other site 1114967005466 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1114967005467 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1114967005468 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1114967005469 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1114967005470 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 1114967005471 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1114967005472 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1114967005473 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1114967005474 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1114967005475 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1114967005476 RNA binding site [nucleotide binding]; other site 1114967005477 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1114967005478 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1114967005479 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1114967005480 23S rRNA interface [nucleotide binding]; other site 1114967005481 putative translocon interaction site; other site 1114967005482 signal recognition particle (SRP54) interaction site; other site 1114967005483 L23 interface [polypeptide binding]; other site 1114967005484 trigger factor interaction site; other site 1114967005485 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1114967005486 23S rRNA interface [nucleotide binding]; other site 1114967005487 5S rRNA interface [nucleotide binding]; other site 1114967005488 putative antibiotic binding site [chemical binding]; other site 1114967005489 L25 interface [polypeptide binding]; other site 1114967005490 L27 interface [polypeptide binding]; other site 1114967005491 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1114967005492 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1114967005493 G-X-X-G motif; other site 1114967005494 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1114967005495 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1114967005496 putative translocon binding site; other site 1114967005497 protein-rRNA interface [nucleotide binding]; other site 1114967005498 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1114967005499 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1114967005500 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1114967005501 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1114967005502 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1114967005503 50S ribosomal protein L4; Provisional; Region: rplD; PRK14547 1114967005504 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1114967005505 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1114967005506 6-carboxyhexanoate--CoA ligase; Region: BioW; pfam03744 1114967005507 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 1114967005508 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1114967005509 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1114967005510 catalytic residue [active] 1114967005511 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1114967005512 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1114967005513 HIGH motif; other site 1114967005514 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1114967005515 active site 1114967005516 KMSKS motif; other site 1114967005517 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 1114967005518 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1114967005519 active site 1114967005520 HIGH motif; other site 1114967005521 nucleotide binding site [chemical binding]; other site 1114967005522 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1114967005523 active site 1114967005524 KMSKS motif; other site 1114967005525 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 1114967005526 potential frameshift: common BLAST hit: gi|50843325|ref|YP_056552.1| 2',3'-cyclic-nucleotide 2'-phosphodiesterase 1114967005527 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 1114967005528 elongation factor Tu; Reviewed; Region: PRK00049 1114967005529 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1114967005530 G1 box; other site 1114967005531 GEF interaction site [polypeptide binding]; other site 1114967005532 GTP/Mg2+ binding site [chemical binding]; other site 1114967005533 Switch I region; other site 1114967005534 G2 box; other site 1114967005535 G3 box; other site 1114967005536 Switch II region; other site 1114967005537 G4 box; other site 1114967005538 G5 box; other site 1114967005539 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1114967005540 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1114967005541 Antibiotic Binding Site [chemical binding]; other site 1114967005542 elongation factor G; Reviewed; Region: PRK00007 1114967005543 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1114967005544 G1 box; other site 1114967005545 putative GEF interaction site [polypeptide binding]; other site 1114967005546 GTP/Mg2+ binding site [chemical binding]; other site 1114967005547 Switch I region; other site 1114967005548 G2 box; other site 1114967005549 G3 box; other site 1114967005550 Switch II region; other site 1114967005551 G4 box; other site 1114967005552 G5 box; other site 1114967005553 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1114967005554 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1114967005555 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1114967005556 30S ribosomal protein S7; Validated; Region: PRK05302 1114967005557 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1114967005558 S17 interaction site [polypeptide binding]; other site 1114967005559 S8 interaction site; other site 1114967005560 16S rRNA interaction site [nucleotide binding]; other site 1114967005561 streptomycin interaction site [chemical binding]; other site 1114967005562 23S rRNA interaction site [nucleotide binding]; other site 1114967005563 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1114967005564 Filamin/ABP280 repeat; Region: Filamin; pfam00630 1114967005565 putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773 1114967005566 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 1114967005567 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 1114967005568 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1114967005569 DNA-directed RNA polymerase, beta' subunit, predominant form; Region: rpoC_TIGR; TIGR02386 1114967005570 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1114967005571 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1114967005572 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1114967005573 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1114967005574 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 1114967005575 G-loop; other site 1114967005576 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1114967005577 DNA binding site [nucleotide binding] 1114967005578 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1114967005579 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1114967005580 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1114967005581 RPB12 interaction site [polypeptide binding]; other site 1114967005582 RPB1 interaction site [polypeptide binding]; other site 1114967005583 RPB10 interaction site [polypeptide binding]; other site 1114967005584 RPB11 interaction site [polypeptide binding]; other site 1114967005585 RPB3 interaction site [polypeptide binding]; other site 1114967005586 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1114967005587 core dimer interface [polypeptide binding]; other site 1114967005588 peripheral dimer interface [polypeptide binding]; other site 1114967005589 L10 interface [polypeptide binding]; other site 1114967005590 L11 interface [polypeptide binding]; other site 1114967005591 putative EF-Tu interaction site [polypeptide binding]; other site 1114967005592 putative EF-G interaction site [polypeptide binding]; other site 1114967005593 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1114967005594 23S rRNA interface [nucleotide binding]; other site 1114967005595 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1114967005596 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1114967005597 mRNA/rRNA interface [nucleotide binding]; other site 1114967005598 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1114967005599 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1114967005600 23S rRNA interface [nucleotide binding]; other site 1114967005601 putative thiostrepton binding site; other site 1114967005602 L7/L12 interface [polypeptide binding]; other site 1114967005603 L25 interface [polypeptide binding]; other site 1114967005604 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1114967005605 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1114967005606 putative homodimer interface [polypeptide binding]; other site 1114967005607 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1114967005608 heterodimer interface [polypeptide binding]; other site 1114967005609 homodimer interface [polypeptide binding]; other site 1114967005610 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 1114967005611 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 1114967005612 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1114967005613 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114967005614 homodimer interface [polypeptide binding]; other site 1114967005615 catalytic residue [active] 1114967005616 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 1114967005617 FAD binding domain; Region: FAD_binding_4; pfam01565 1114967005618 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1114967005619 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 1114967005620 active site 1114967005621 catalytic site [active] 1114967005622 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1114967005623 active site 1114967005624 catalytic site [active] 1114967005625 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 1114967005626 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 1114967005627 putative active site [active] 1114967005628 putative catalytic site [active] 1114967005629 putative DNA binding site [nucleotide binding]; other site 1114967005630 putative phosphate binding site [ion binding]; other site 1114967005631 metal binding site A [ion binding]; metal-binding site 1114967005632 putative AP binding site [nucleotide binding]; other site 1114967005633 putative metal binding site B [ion binding]; other site 1114967005634 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1114967005635 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 1114967005636 substrate binding site [chemical binding]; other site 1114967005637 oxyanion hole (OAH) forming residues; other site 1114967005638 trimer interface [polypeptide binding]; other site 1114967005639 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 1114967005640 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 1114967005641 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 1114967005642 4Fe-4S binding domain; Region: Fer4; cl02805 1114967005643 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329 1114967005644 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194 1114967005645 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 1114967005646 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1114967005647 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1114967005648 dimer interface [polypeptide binding]; other site 1114967005649 PYR/PP interface [polypeptide binding]; other site 1114967005650 TPP binding site [chemical binding]; other site 1114967005651 substrate binding site [chemical binding]; other site 1114967005652 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 1114967005653 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 1114967005654 TPP-binding site [chemical binding]; other site 1114967005655 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 1114967005656 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 1114967005657 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 1114967005658 active site 1114967005659 catalytic triad [active] 1114967005660 oxyanion hole [active] 1114967005661 Thrombospondin type 3 repeat; Region: TSP_3; pfam02412 1114967005662 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 1114967005663 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 1114967005664 active site 1114967005665 Zn binding site [ion binding]; other site 1114967005666 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114967005667 heme ABC exporter, ATP-binding protein CcmA; Region: ccmA; TIGR01189 1114967005668 Walker A/P-loop; other site 1114967005669 ATP binding site [chemical binding]; other site 1114967005670 Q-loop/lid; other site 1114967005671 ABC transporter signature motif; other site 1114967005672 Walker B; other site 1114967005673 D-loop; other site 1114967005674 H-loop/switch region; other site 1114967005675 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1114967005676 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1114967005677 Walker A/P-loop; other site 1114967005678 ATP binding site [chemical binding]; other site 1114967005679 Q-loop/lid; other site 1114967005680 ABC transporter signature motif; other site 1114967005681 Walker B; other site 1114967005682 D-loop; other site 1114967005683 H-loop/switch region; other site 1114967005684 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1114967005685 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 1114967005686 active site 1114967005687 SAM binding site [chemical binding]; other site 1114967005688 homodimer interface [polypeptide binding]; other site 1114967005689 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1114967005690 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1114967005691 substrate binding pocket [chemical binding]; other site 1114967005692 chain length determination region; other site 1114967005693 substrate-Mg2+ binding site; other site 1114967005694 catalytic residues [active] 1114967005695 aspartate-rich region 1; other site 1114967005696 active site lid residues [active] 1114967005697 aspartate-rich region 2; other site 1114967005698 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1114967005699 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1114967005700 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1114967005701 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1114967005702 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1114967005703 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1114967005704 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1114967005705 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1114967005706 NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839 1114967005707 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 1114967005708 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 1114967005709 4Fe-4S binding domain; Region: Fer4; pfam00037 1114967005710 4Fe-4S binding domain; Region: Fer4; pfam00037 1114967005711 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1114967005712 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1114967005713 NADH dehydrogenase subunit G; Validated; Region: PRK07860 1114967005714 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1114967005715 catalytic loop [active] 1114967005716 iron binding site [ion binding]; other site 1114967005717 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1114967005718 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 1114967005719 [4Fe-4S] binding site [ion binding]; other site 1114967005720 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 1114967005721 molybdopterin cofactor binding site; other site 1114967005722 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 1114967005723 SLBB domain; Region: SLBB; pfam10531 1114967005724 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 1114967005725 NADH dehydrogenase subunit E; Validated; Region: PRK07539 1114967005726 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1114967005727 putative dimer interface [polypeptide binding]; other site 1114967005728 [2Fe-2S] cluster binding site [ion binding]; other site 1114967005729 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 1114967005730 NADH dehydrogenase subunit D; Validated; Region: PRK06075 1114967005731 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 1114967005732 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 1114967005733 NADH dehydrogenase subunit B; Validated; Region: PRK06411 1114967005734 NADH dehydrogenase subunit A; Validated; Region: PRK07928 1114967005735 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 1114967005736 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1114967005737 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539 1114967005738 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1114967005739 Walker A/P-loop; other site 1114967005740 ATP binding site [chemical binding]; other site 1114967005741 Q-loop/lid; other site 1114967005742 ABC transporter signature motif; other site 1114967005743 Walker B; other site 1114967005744 D-loop; other site 1114967005745 H-loop/switch region; other site 1114967005746 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1114967005747 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114967005748 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1114967005749 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1114967005750 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 1114967005751 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114967005752 Walker A/P-loop; other site 1114967005753 ATP binding site [chemical binding]; other site 1114967005754 Q-loop/lid; other site 1114967005755 ABC transporter signature motif; other site 1114967005756 Walker B; other site 1114967005757 D-loop; other site 1114967005758 H-loop/switch region; other site 1114967005759 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1114967005760 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1114967005761 Walker A/P-loop; other site 1114967005762 ATP binding site [chemical binding]; other site 1114967005763 Q-loop/lid; other site 1114967005764 ABC transporter signature motif; other site 1114967005765 Walker B; other site 1114967005766 D-loop; other site 1114967005767 H-loop/switch region; other site 1114967005768 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 1114967005769 UbiA prenyltransferase family; Region: UbiA; pfam01040 1114967005770 H+ Antiporter protein; Region: 2A0121; TIGR00900 1114967005771 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114967005772 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114967005773 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 1114967005774 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 1114967005775 DAK2 domain; Region: Dak2; cl03685 1114967005776 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 1114967005777 active pocket/dimerization site; other site 1114967005778 active site 1114967005779 phosphorylation site [posttranslational modification] 1114967005780 Deoxycytidylate deaminase [Nucleotide transport and metabolism]; Region: ComEB; COG2131 1114967005781 active site 1114967005782 Zn binding site [ion binding]; other site 1114967005783 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1114967005784 Cation efflux family; Region: Cation_efflux; cl00316 1114967005785 A subgroup of L-lactate dehydrogenases; Region: LDH_3; cd05290 1114967005786 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 1114967005787 NAD binding site [chemical binding]; other site 1114967005788 dimer interface [polypeptide binding]; other site 1114967005789 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1114967005790 substrate binding site [chemical binding]; other site 1114967005791 Patatin-like phospholipase; Region: Patatin; pfam01734 1114967005792 active site 1114967005793 nucleophile elbow; other site 1114967005794 Patatin-like phospholipase; Region: Patatin; pfam01734 1114967005795 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114967005796 UMP phosphatase; Provisional; Region: PRK10444 1114967005797 active site 1114967005798 motif I; other site 1114967005799 motif II; other site 1114967005800 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114967005801 Right handed beta helix region; Region: Beta_helix; pfam13229 1114967005802 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 1114967005803 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1114967005804 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1114967005805 Domain of unknown function (DUF4091); Region: DUF4091; pfam13320 1114967005806 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114967005807 dimer interface [polypeptide binding]; other site 1114967005808 conserved gate region; other site 1114967005809 putative PBP binding loops; other site 1114967005810 ABC-ATPase subunit interface; other site 1114967005811 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1114967005812 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114967005813 dimer interface [polypeptide binding]; other site 1114967005814 conserved gate region; other site 1114967005815 putative PBP binding loops; other site 1114967005816 ABC-ATPase subunit interface; other site 1114967005817 potential frameshift: common BLAST hit: gi|50843409|ref|YP_056636.1| sugar-binding periplasmic protein 1114967005818 Bacterial SH3 domain; Region: SH3_3; pfam08239 1114967005819 Bacterial SH3 domain; Region: SH3_3; cl17532 1114967005820 Bacterial SH3 domain; Region: SH3_3; cl17532 1114967005821 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1114967005822 NlpC/P60 family; Region: NLPC_P60; cl17555 1114967005823 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1114967005824 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114967005825 dimer interface [polypeptide binding]; other site 1114967005826 conserved gate region; other site 1114967005827 putative PBP binding loops; other site 1114967005828 ABC-ATPase subunit interface; other site 1114967005829 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114967005830 dimer interface [polypeptide binding]; other site 1114967005831 conserved gate region; other site 1114967005832 putative PBP binding loops; other site 1114967005833 ABC-ATPase subunit interface; other site 1114967005834 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1114967005835 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1114967005836 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1114967005837 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 1114967005838 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1114967005839 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1114967005840 dimerization interface [polypeptide binding]; other site 1114967005841 putative ATP binding site [chemical binding]; other site 1114967005842 amidophosphoribosyltransferase; Provisional; Region: PRK07847 1114967005843 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1114967005844 active site 1114967005845 tetramer interface [polypeptide binding]; other site 1114967005846 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1114967005847 active site 1114967005848 hypothetical protein; Provisional; Region: PRK07907 1114967005849 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 1114967005850 active site 1114967005851 metal binding site [ion binding]; metal-binding site 1114967005852 dimer interface [polypeptide binding]; other site 1114967005853 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1114967005854 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1114967005855 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 1114967005856 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1114967005857 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1114967005858 glutamine binding [chemical binding]; other site 1114967005859 catalytic triad [active] 1114967005860 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1114967005861 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 1114967005862 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1114967005863 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1114967005864 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1114967005865 dimerization interface [polypeptide binding]; other site 1114967005866 ATP binding site [chemical binding]; other site 1114967005867 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1114967005868 dimerization interface [polypeptide binding]; other site 1114967005869 ATP binding site [chemical binding]; other site 1114967005870 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114967005871 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114967005872 putative substrate translocation pore; other site 1114967005873 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 1114967005874 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 1114967005875 Zn binding site [ion binding]; other site 1114967005876 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 1114967005877 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1114967005878 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1114967005879 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1114967005880 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 1114967005881 active site 1114967005882 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1114967005883 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 1114967005884 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 1114967005885 active site 1114967005886 catalytic triad [active] 1114967005887 oxyanion hole [active] 1114967005888 Thrombospondin type 3 repeat; Region: TSP_3; pfam02412 1114967005889 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1114967005890 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1114967005891 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1114967005892 putative active site [active] 1114967005893 catalytic triad [active] 1114967005894 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 1114967005895 ATP binding site [chemical binding]; other site 1114967005896 active site 1114967005897 substrate binding site [chemical binding]; other site 1114967005898 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 1114967005899 peroxiredoxin; Region: AhpC; TIGR03137 1114967005900 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1114967005901 dimer interface [polypeptide binding]; other site 1114967005902 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1114967005903 catalytic triad [active] 1114967005904 peroxidatic and resolving cysteines [active] 1114967005905 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 1114967005906 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1114967005907 catalytic residue [active] 1114967005908 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 1114967005909 catalytic residues [active] 1114967005910 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1114967005911 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1114967005912 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114967005913 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114967005914 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 1114967005915 dimerization interface [polypeptide binding]; other site 1114967005916 adenylosuccinate lyase; Region: purB; TIGR00928 1114967005917 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 1114967005918 tetramer interface [polypeptide binding]; other site 1114967005919 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1114967005920 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1114967005921 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1114967005922 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1114967005923 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1114967005924 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1114967005925 GDP-binding site [chemical binding]; other site 1114967005926 ACT binding site; other site 1114967005927 IMP binding site; other site 1114967005928 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114967005929 Coenzyme A binding pocket [chemical binding]; other site 1114967005930 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1114967005931 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114967005932 DNA-binding site [nucleotide binding]; DNA binding site 1114967005933 FCD domain; Region: FCD; pfam07729 1114967005934 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 1114967005935 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 1114967005936 putative active site cavity [active] 1114967005937 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1114967005938 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1114967005939 inhibitor site; inhibition site 1114967005940 active site 1114967005941 dimer interface [polypeptide binding]; other site 1114967005942 catalytic residue [active] 1114967005943 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1114967005944 putative sialic acid transporter; Provisional; Region: PRK03893 1114967005945 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114967005946 putative substrate translocation pore; other site 1114967005947 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114967005948 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 1114967005949 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1114967005950 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 1114967005951 G1 box; other site 1114967005952 putative GEF interaction site [polypeptide binding]; other site 1114967005953 GTP/Mg2+ binding site [chemical binding]; other site 1114967005954 Switch I region; other site 1114967005955 G2 box; other site 1114967005956 G3 box; other site 1114967005957 Switch II region; other site 1114967005958 G4 box; other site 1114967005959 G5 box; other site 1114967005960 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1114967005961 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1114967005962 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1114967005963 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1114967005964 carboxyltransferase (CT) interaction site; other site 1114967005965 biotinylation site [posttranslational modification]; other site 1114967005966 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 1114967005967 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1114967005968 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1114967005969 oxaloacetate decarboxylase; Provisional; Region: PRK12330 1114967005970 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1114967005971 active site 1114967005972 catalytic residues [active] 1114967005973 metal binding site [ion binding]; metal-binding site 1114967005974 homodimer binding site [polypeptide binding]; other site 1114967005975 PAS domain; Region: PAS_9; pfam13426 1114967005976 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1114967005977 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 1114967005978 active site 1114967005979 intersubunit interface [polypeptide binding]; other site 1114967005980 zinc binding site [ion binding]; other site 1114967005981 Na+ binding site [ion binding]; other site 1114967005982 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1114967005983 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1114967005984 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1114967005985 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1114967005986 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1114967005987 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1114967005988 SEC-C motif; Region: SEC-C; pfam02810 1114967005989 hypothetical protein; Provisional; Region: PRK04233 1114967005990 potential frameshift: common BLAST hit: gi|295131548|ref|YP_003582211.1| transporter, major facilitator family protein 1114967005991 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1114967005992 Clp amino terminal domain; Region: Clp_N; pfam02861 1114967005993 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114967005994 Walker A motif; other site 1114967005995 ATP binding site [chemical binding]; other site 1114967005996 Walker B motif; other site 1114967005997 arginine finger; other site 1114967005998 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114967005999 Walker A motif; other site 1114967006000 ATP binding site [chemical binding]; other site 1114967006001 Walker B motif; other site 1114967006002 arginine finger; other site 1114967006003 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1114967006004 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 1114967006005 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 1114967006006 Eukaryotic phosphomannomutase; Region: PMM; cl17107 1114967006007 fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377 1114967006008 catalytic residue [active] 1114967006009 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 1114967006010 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 1114967006011 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1114967006012 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1114967006013 Histidine kinase; Region: HisKA_3; pfam07730 1114967006014 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114967006015 ATP binding site [chemical binding]; other site 1114967006016 Mg2+ binding site [ion binding]; other site 1114967006017 G-X-G motif; other site 1114967006018 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1114967006019 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114967006020 active site 1114967006021 phosphorylation site [posttranslational modification] 1114967006022 intermolecular recognition site; other site 1114967006023 dimerization interface [polypeptide binding]; other site 1114967006024 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1114967006025 DNA binding residues [nucleotide binding] 1114967006026 dimerization interface [polypeptide binding]; other site 1114967006027 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1114967006028 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1114967006029 Walker A/P-loop; other site 1114967006030 ATP binding site [chemical binding]; other site 1114967006031 Q-loop/lid; other site 1114967006032 ABC transporter signature motif; other site 1114967006033 Walker B; other site 1114967006034 D-loop; other site 1114967006035 H-loop/switch region; other site 1114967006036 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1114967006037 FtsX-like permease family; Region: FtsX; pfam02687 1114967006038 FtsX-like permease family; Region: FtsX; pfam02687 1114967006039 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 1114967006040 nudix motif; other site 1114967006041 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1114967006042 Predicted permease [General function prediction only]; Region: COG2985 1114967006043 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 1114967006044 TrkA-C domain; Region: TrkA_C; pfam02080 1114967006045 TrkA-C domain; Region: TrkA_C; pfam02080 1114967006046 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 1114967006047 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1114967006048 6-hydroxycyclohex-1-ene-1-carboxyl-CoA dehydrogenase, N-benzyl-3-pyrrolidinol dehydrogenase, and other MDR family members; Region: hydroxyacyl_CoA_DH; cd08254 1114967006049 putative NAD(P) binding site [chemical binding]; other site 1114967006050 catalytic Zn binding site [ion binding]; other site 1114967006051 structural Zn binding site [ion binding]; other site 1114967006052 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1114967006053 active site 1114967006054 catalytic triad [active] 1114967006055 oxyanion hole [active] 1114967006056 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 1114967006057 DNA binding residues [nucleotide binding] 1114967006058 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1114967006059 putative dimer interface [polypeptide binding]; other site 1114967006060 chaperone protein DnaJ; Provisional; Region: PRK14295 1114967006061 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1114967006062 HSP70 interaction site [polypeptide binding]; other site 1114967006063 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1114967006064 Zn binding sites [ion binding]; other site 1114967006065 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1114967006066 dimer interface [polypeptide binding]; other site 1114967006067 GrpE; Region: GrpE; pfam01025 1114967006068 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1114967006069 dimer interface [polypeptide binding]; other site 1114967006070 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1114967006071 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1114967006072 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1114967006073 nucleotide binding site [chemical binding]; other site 1114967006074 NEF interaction site [polypeptide binding]; other site 1114967006075 SBD interface [polypeptide binding]; other site 1114967006076 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1114967006077 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1114967006078 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114967006079 active site 1114967006080 phosphorylation site [posttranslational modification] 1114967006081 intermolecular recognition site; other site 1114967006082 dimerization interface [polypeptide binding]; other site 1114967006083 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1114967006084 DNA binding site [nucleotide binding] 1114967006085 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1114967006086 intersubunit interface [polypeptide binding]; other site 1114967006087 active site 1114967006088 catalytic residue [active] 1114967006089 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1; cd01653 1114967006090 conserved cys residue [active] 1114967006091 FHA domain; Region: FHA; pfam00498 1114967006092 phosphopeptide binding site; other site 1114967006093 pyruvate phosphate dikinase; Provisional; Region: PRK09279 1114967006094 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1114967006095 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1114967006096 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1114967006097 PEP synthetase regulatory protein; Provisional; Region: PRK05339 1114967006098 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 1114967006099 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114967006100 S-adenosylmethionine binding site [chemical binding]; other site 1114967006101 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1114967006102 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1114967006103 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 1114967006104 active site 1114967006105 catalytic residues [active] 1114967006106 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 1114967006107 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 1114967006108 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1114967006109 potential frameshift: common BLAST hit: gi|50843498|ref|YP_056725.1| amidase 1114967006110 potential protein location (hypothetical protein TIA2EST22_10060 [Propionibacterium acnes TypeIA2 P.acn17]) that overlaps RNA (tRNA-G) 1114967006111 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 1114967006112 putative active site [active] 1114967006113 homotetrameric interface [polypeptide binding]; other site 1114967006114 metal binding site [ion binding]; metal-binding site 1114967006115 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 1114967006116 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 1114967006117 active site 1114967006118 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 1114967006119 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114967006120 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1114967006121 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114967006122 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1114967006123 Walker A/P-loop; other site 1114967006124 ATP binding site [chemical binding]; other site 1114967006125 Q-loop/lid; other site 1114967006126 ABC transporter signature motif; other site 1114967006127 Walker B; other site 1114967006128 D-loop; other site 1114967006129 H-loop/switch region; other site 1114967006130 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1114967006131 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1114967006132 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114967006133 Walker A/P-loop; other site 1114967006134 ATP binding site [chemical binding]; other site 1114967006135 Q-loop/lid; other site 1114967006136 ABC transporter signature motif; other site 1114967006137 Walker B; other site 1114967006138 D-loop; other site 1114967006139 H-loop/switch region; other site 1114967006140 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; cl09823 1114967006141 EcsC protein family; Region: EcsC; pfam12787 1114967006142 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1114967006143 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1114967006144 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1114967006145 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 1114967006146 Walker A/P-loop; other site 1114967006147 ATP binding site [chemical binding]; other site 1114967006148 Q-loop/lid; other site 1114967006149 ABC transporter signature motif; other site 1114967006150 Walker B; other site 1114967006151 D-loop; other site 1114967006152 H-loop/switch region; other site 1114967006153 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1114967006154 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1114967006155 E3 interaction surface; other site 1114967006156 lipoyl attachment site [posttranslational modification]; other site 1114967006157 e3 binding domain; Region: E3_binding; pfam02817 1114967006158 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1114967006159 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1114967006160 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1114967006161 alpha subunit interface [polypeptide binding]; other site 1114967006162 TPP binding site [chemical binding]; other site 1114967006163 heterodimer interface [polypeptide binding]; other site 1114967006164 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1114967006165 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1114967006166 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1114967006167 TPP-binding site [chemical binding]; other site 1114967006168 tetramer interface [polypeptide binding]; other site 1114967006169 heterodimer interface [polypeptide binding]; other site 1114967006170 phosphorylation loop region [posttranslational modification] 1114967006171 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1114967006172 radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053 1114967006173 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1114967006174 FeS/SAM binding site; other site 1114967006175 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1114967006176 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1114967006177 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1114967006178 active site 1114967006179 metal binding site [ion binding]; metal-binding site 1114967006180 potential frameshift: common BLAST hit: gi|50843536|ref|YP_056763.1| 5'-nucleotidase 1114967006181 potential frameshift: common BLAST hit: gi|50843536|ref|YP_056763.1| 5'-nucleotidase 1114967006182 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114967006183 H-loop/switch region; other site 1114967006184 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1114967006185 potential frameshift: common BLAST hit: gi|30387203|ref|NP_848180.1| putative transcriptional regulator 1114967006186 HTH domain; Region: HTH_11; pfam08279 1114967006187 potential frameshift: common BLAST hit: gi|226308065|ref|YP_002768025.1| drug resistance protein 1114967006188 Integrase core domain; Region: rve_3; pfam13683 1114967006189 Lipase (class 2); Region: Lipase_2; pfam01674 1114967006190 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 1114967006191 CAMP factor (Cfa); Region: CAMP_factor; pfam07373 1114967006192 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1114967006193 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1114967006194 active site 1114967006195 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 1114967006196 proposed catalytic triad [active] 1114967006197 active site nucleophile [active] 1114967006198 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1114967006199 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114967006200 active site 1114967006201 phosphorylation site [posttranslational modification] 1114967006202 intermolecular recognition site; other site 1114967006203 dimerization interface [polypeptide binding]; other site 1114967006204 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1114967006205 DNA binding site [nucleotide binding] 1114967006206 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1114967006207 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114967006208 dimerization interface [polypeptide binding]; other site 1114967006209 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114967006210 dimer interface [polypeptide binding]; other site 1114967006211 phosphorylation site [posttranslational modification] 1114967006212 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114967006213 ATP binding site [chemical binding]; other site 1114967006214 Mg2+ binding site [ion binding]; other site 1114967006215 G-X-G motif; other site 1114967006216 Ntn-hydrolase superfamily, L-Asparaginase type 2-like enzymes. This family includes Glycosylasparaginase, Taspase 1 and L-Asparaginase type 2 enzymes. Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked...; Region: Ntn_Asparaginase_2_like; cl00635 1114967006217 Ntn-hydrolase superfamily, L-Asparaginase type 2-like enzymes. This family includes Glycosylasparaginase, Taspase 1 and L-Asparaginase type 2 enzymes. Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked...; Region: Ntn_Asparaginase_2_like; cl00635 1114967006218 active site 1114967006219 catalytic nucleophile [active] 1114967006220 dimer interface [polypeptide binding]; other site 1114967006221 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 1114967006222 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 1114967006223 active site 1114967006224 metal binding site [ion binding]; metal-binding site 1114967006225 nudix motif; other site 1114967006226 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1114967006227 YCII-related domain; Region: YCII; cl00999 1114967006228 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1114967006229 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 1114967006230 active site 1114967006231 FMN binding site [chemical binding]; other site 1114967006232 substrate binding site [chemical binding]; other site 1114967006233 homotetramer interface [polypeptide binding]; other site 1114967006234 catalytic residue [active] 1114967006235 metabolite-proton symporter; Region: 2A0106; TIGR00883 1114967006236 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114967006237 putative substrate translocation pore; other site 1114967006238 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK06539 1114967006239 ATP cone domain; Region: ATP-cone; pfam03477 1114967006240 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1114967006241 active site 1114967006242 dimer interface [polypeptide binding]; other site 1114967006243 catalytic residues [active] 1114967006244 effector binding site; other site 1114967006245 R2 peptide binding site; other site 1114967006246 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1114967006247 dimer interface [polypeptide binding]; other site 1114967006248 putative radical transfer pathway; other site 1114967006249 diiron center [ion binding]; other site 1114967006250 tyrosyl radical; other site 1114967006251 Bacterial PH domain; Region: DUF304; pfam03703 1114967006252 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1114967006253 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1114967006254 nucleotide binding site [chemical binding]; other site 1114967006255 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 1114967006256 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1114967006257 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 1114967006258 arginine-tRNA ligase; Region: PLN02286 1114967006259 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1114967006260 active site 1114967006261 HIGH motif; other site 1114967006262 KMSK motif region; other site 1114967006263 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1114967006264 tRNA binding surface [nucleotide binding]; other site 1114967006265 anticodon binding site; other site 1114967006266 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1114967006267 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1114967006268 active site 1114967006269 catalytic tetrad [active] 1114967006270 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1114967006271 putative active site [active] 1114967006272 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1114967006273 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1114967006274 active site 1114967006275 dimer interface [polypeptide binding]; other site 1114967006276 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1114967006277 dimer interface [polypeptide binding]; other site 1114967006278 active site 1114967006279 MG2 domain; Region: A2M_N; pfam01835 1114967006280 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1114967006281 active site 1114967006282 intersubunit interface [polypeptide binding]; other site 1114967006283 catalytic residue [active] 1114967006284 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1114967006285 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1114967006286 dimerization interface [polypeptide binding]; other site 1114967006287 DPS ferroxidase diiron center [ion binding]; other site 1114967006288 ion pore; other site 1114967006289 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1114967006290 ATP binding site [chemical binding]; other site 1114967006291 putative Mg++ binding site [ion binding]; other site 1114967006292 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1114967006293 nucleotide binding region [chemical binding]; other site 1114967006294 ATP-binding site [chemical binding]; other site 1114967006295 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 1114967006296 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 1114967006297 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1114967006298 FeS/SAM binding site; other site 1114967006299 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK07111 1114967006300 ATP cone domain; Region: ATP-cone; pfam03477 1114967006301 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1114967006302 Class III ribonucleotide reductase; Region: RNR_III; cd01675 1114967006303 active site 1114967006304 Zn binding site [ion binding]; other site 1114967006305 glycine loop; other site 1114967006306 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1114967006307 substrate binding site [chemical binding]; other site 1114967006308 Cutinase; Region: Cutinase; pfam01083 1114967006309 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1114967006310 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1114967006311 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1114967006312 NodB motif; other site 1114967006313 active site 1114967006314 catalytic site [active] 1114967006315 metal binding site [ion binding]; metal-binding site 1114967006316 TIGR03943 family protein; Region: TIGR03943 1114967006317 Predicted permease; Region: DUF318; cl17795 1114967006318 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1114967006319 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1114967006320 NodB motif; other site 1114967006321 active site 1114967006322 catalytic site [active] 1114967006323 metal binding site [ion binding]; metal-binding site 1114967006324 integral membrane protein MviN; Region: mviN; TIGR01695 1114967006325 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1114967006326 aspartate kinase; Reviewed; Region: PRK06635 1114967006327 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1114967006328 putative nucleotide binding site [chemical binding]; other site 1114967006329 putative catalytic residues [active] 1114967006330 putative Mg ion binding site [ion binding]; other site 1114967006331 putative aspartate binding site [chemical binding]; other site 1114967006332 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1114967006333 putative allosteric regulatory site; other site 1114967006334 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1114967006335 putative allosteric regulatory residue; other site 1114967006336 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1114967006337 Transglycosylase; Region: Transgly; pfam00912 1114967006338 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1114967006339 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 1114967006340 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1114967006341 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1114967006342 putative active site [active] 1114967006343 putative metal binding site [ion binding]; other site 1114967006344 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1114967006345 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1114967006346 proposed catalytic triad [active] 1114967006347 conserved cys residue [active] 1114967006348 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1114967006349 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1114967006350 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1114967006351 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1114967006352 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114967006353 ABC-ATPase subunit interface; other site 1114967006354 putative PBP binding loops; other site 1114967006355 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1114967006356 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1114967006357 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114967006358 dimer interface [polypeptide binding]; other site 1114967006359 conserved gate region; other site 1114967006360 putative PBP binding loops; other site 1114967006361 ABC-ATPase subunit interface; other site 1114967006362 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1114967006363 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1114967006364 Walker A/P-loop; other site 1114967006365 ATP binding site [chemical binding]; other site 1114967006366 Q-loop/lid; other site 1114967006367 ABC transporter signature motif; other site 1114967006368 Walker B; other site 1114967006369 D-loop; other site 1114967006370 H-loop/switch region; other site 1114967006371 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1114967006372 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1114967006373 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1114967006374 Walker A/P-loop; other site 1114967006375 ATP binding site [chemical binding]; other site 1114967006376 Q-loop/lid; other site 1114967006377 ABC transporter signature motif; other site 1114967006378 Walker B; other site 1114967006379 D-loop; other site 1114967006380 H-loop/switch region; other site 1114967006381 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1114967006382 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1114967006383 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1114967006384 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1114967006385 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1114967006386 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1114967006387 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1114967006388 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1114967006389 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1114967006390 urocanate hydratase; Provisional; Region: PRK05414 1114967006391 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1114967006392 allantoate amidohydrolase; Reviewed; Region: PRK09290 1114967006393 active site 1114967006394 metal binding site [ion binding]; metal-binding site 1114967006395 dimer interface [polypeptide binding]; other site 1114967006396 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 1114967006397 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1114967006398 active site 1114967006399 imidazolonepropionase; Provisional; Region: PRK14085 1114967006400 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 1114967006401 active site 1114967006402 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1114967006403 active sites [active] 1114967006404 tetramer interface [polypeptide binding]; other site 1114967006405 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 1114967006406 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09755 1114967006407 NAD-dependent deacetylase; Provisional; Region: PRK00481 1114967006408 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 1114967006409 NAD+ binding site [chemical binding]; other site 1114967006410 substrate binding site [chemical binding]; other site 1114967006411 Zn binding site [ion binding]; other site 1114967006412 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1114967006413 Bacterial SH3 domain; Region: SH3_3; pfam08239 1114967006414 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1114967006415 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1114967006416 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 1114967006417 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1114967006418 potassium/proton antiporter; Reviewed; Region: PRK05326 1114967006419 TrkA-C domain; Region: TrkA_C; pfam02080 1114967006420 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1114967006421 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1114967006422 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1114967006423 nucleoside/Zn binding site; other site 1114967006424 dimer interface [polypeptide binding]; other site 1114967006425 catalytic motif [active] 1114967006426 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 1114967006427 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1114967006428 active site 1114967006429 Uncharacterized conserved protein [Function unknown]; Region: COG3777 1114967006430 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1114967006431 active site 1114967006432 catalytic site [active] 1114967006433 PA2301 is an uncharacterized Pseudomonas aeruginosa protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's...; Region: PA2301; cd04939 1114967006434 putative deacylase active site [active] 1114967006435 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1114967006436 K+ potassium transporter; Region: K_trans; pfam02705 1114967006437 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1114967006438 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1114967006439 catalytic triad [active] 1114967006440 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1114967006441 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1114967006442 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1114967006443 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1114967006444 DNA binding site [nucleotide binding] 1114967006445 domain linker motif; other site 1114967006446 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 1114967006447 ligand binding site [chemical binding]; other site 1114967006448 dimerization interface (open form) [polypeptide binding]; other site 1114967006449 dimerization interface (closed form) [polypeptide binding]; other site 1114967006450 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1114967006451 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 1114967006452 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u2; cd11478 1114967006453 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1114967006454 Na binding site [ion binding]; other site 1114967006455 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1114967006456 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 1114967006457 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 1114967006458 NAD(P) binding site [chemical binding]; other site 1114967006459 argininosuccinate synthase; Validated; Region: PRK05370 1114967006460 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114967006461 putative substrate translocation pore; other site 1114967006462 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114967006463 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1114967006464 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1114967006465 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1114967006466 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1114967006467 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114967006468 active site 1114967006469 motif I; other site 1114967006470 motif II; other site 1114967006471 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114967006472 thiazolylpeptide-type bacteriocin precursor; Region: thiopep_precurs; TIGR03892 1114967006473 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1114967006474 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1114967006475 Walker A/P-loop; other site 1114967006476 ATP binding site [chemical binding]; other site 1114967006477 Q-loop/lid; other site 1114967006478 ABC transporter signature motif; other site 1114967006479 Walker B; other site 1114967006480 D-loop; other site 1114967006481 H-loop/switch region; other site 1114967006482 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1114967006483 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1114967006484 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1114967006485 non-specific DNA binding site [nucleotide binding]; other site 1114967006486 salt bridge; other site 1114967006487 sequence-specific DNA binding site [nucleotide binding]; other site 1114967006488 Cupin domain; Region: Cupin_2; pfam07883 1114967006489 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 1114967006490 B3/4 domain; Region: B3_4; pfam03483 1114967006491 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1114967006492 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1114967006493 Na binding site [ion binding]; other site 1114967006494 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 1114967006495 CIDE_N domain, found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) proteins, as well as CAD nuclease (caspase-activated DNase/DNA fragmentation factor, DFF40) and its inhibitor, ICAD(DFF45). These proteins are associated with...; Region: CIDE_N; cl02541 1114967006496 oxidoreductase; Provisional; Region: PRK10015 1114967006497 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1114967006498 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1114967006499 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1114967006500 Ligand binding site [chemical binding]; other site 1114967006501 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1114967006502 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1114967006503 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1114967006504 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1114967006505 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1114967006506 active site 1114967006507 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1114967006508 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1114967006509 Bacterial transcriptional regulator; Region: IclR; pfam01614 1114967006510 seryl-tRNA synthetase; Provisional; Region: PRK05431 1114967006511 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1114967006512 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1114967006513 dimer interface [polypeptide binding]; other site 1114967006514 active site 1114967006515 motif 1; other site 1114967006516 motif 2; other site 1114967006517 motif 3; other site 1114967006518 PRC-barrel domain; Region: PRC; pfam05239 1114967006519 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 1114967006520 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1114967006521 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 1114967006522 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1114967006523 phosphate binding motif [ion binding]; other site 1114967006524 Siderophore-interacting protein; Region: SIP; pfam04954 1114967006525 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 1114967006526 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1114967006527 Ferritin-like domain; Region: Ferritin; pfam00210 1114967006528 ferroxidase diiron center [ion binding]; other site 1114967006529 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1114967006530 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1114967006531 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1114967006532 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1114967006533 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1114967006534 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1114967006535 dimer interface [polypeptide binding]; other site 1114967006536 ssDNA binding site [nucleotide binding]; other site 1114967006537 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1114967006538 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1114967006539 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1114967006540 active site residue [active] 1114967006541 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1114967006542 active site 1114967006543 phosphorylation site [posttranslational modification] 1114967006544 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 1114967006545 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1114967006546 active site 1114967006547 P-loop; other site 1114967006548 phosphorylation site [posttranslational modification] 1114967006549 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1114967006550 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1114967006551 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1114967006552 acyl-activating enzyme (AAE) consensus motif; other site 1114967006553 putative AMP binding site [chemical binding]; other site 1114967006554 putative active site [active] 1114967006555 putative CoA binding site [chemical binding]; other site 1114967006556 endonuclease IV; Provisional; Region: PRK01060 1114967006557 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1114967006558 AP (apurinic/apyrimidinic) site pocket; other site 1114967006559 DNA interaction; other site 1114967006560 Metal-binding active site; metal-binding site 1114967006561 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1114967006562 classical (c) SDRs; Region: SDR_c; cd05233 1114967006563 NAD(P) binding site [chemical binding]; other site 1114967006564 active site 1114967006565 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1114967006566 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1114967006567 putative acyl-acceptor binding pocket; other site 1114967006568 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 1114967006569 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1114967006570 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1114967006571 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1114967006572 G5 domain; Region: G5; pfam07501 1114967006573 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1114967006574 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1114967006575 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1114967006576 metal-binding site [ion binding] 1114967006577 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1114967006578 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1114967006579 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1114967006580 metal-binding site [ion binding] 1114967006581 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 1114967006582 putative homodimer interface [polypeptide binding]; other site 1114967006583 putative homotetramer interface [polypeptide binding]; other site 1114967006584 putative allosteric switch controlling residues; other site 1114967006585 putative metal binding site [ion binding]; other site 1114967006586 putative homodimer-homodimer interface [polypeptide binding]; other site 1114967006587 replicative DNA helicase; Region: DnaB; TIGR00665 1114967006588 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1114967006589 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1114967006590 Walker A motif; other site 1114967006591 ATP binding site [chemical binding]; other site 1114967006592 Walker B motif; other site 1114967006593 DNA binding loops [nucleotide binding] 1114967006594 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 1114967006595 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 1114967006596 putative NAD(P) binding site [chemical binding]; other site 1114967006597 dimer interface [polypeptide binding]; other site 1114967006598 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1114967006599 active site 1114967006600 DNA binding site [nucleotide binding] 1114967006601 sn-glycerol-3-phosphate dehydrogenase subunit C; Provisional; Region: glpC; PRK11168 1114967006602 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 1114967006603 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1114967006604 glycerol-3-phosphate dehydrogenase, anaerobic, A subunit; Region: glycerol3P_GlpA; TIGR03377 1114967006605 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1114967006606 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 1114967006607 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1114967006608 dimerization interface [polypeptide binding]; other site 1114967006609 ligand binding site [chemical binding]; other site 1114967006610 NADP binding site [chemical binding]; other site 1114967006611 catalytic site [active] 1114967006612 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1114967006613 MarR family; Region: MarR_2; cl17246 1114967006614 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 1114967006615 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1114967006616 Cl- selectivity filter; other site 1114967006617 Cl- binding residues [ion binding]; other site 1114967006618 pore gating glutamate residue; other site 1114967006619 dimer interface [polypeptide binding]; other site 1114967006620 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1114967006621 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1114967006622 MarR family; Region: MarR_2; pfam12802 1114967006623 MarR family; Region: MarR_2; cl17246 1114967006624 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1114967006625 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1114967006626 active site 1114967006627 metal binding site [ion binding]; metal-binding site 1114967006628 Predicted ATPases [General function prediction only]; Region: COG1106 1114967006629 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1114967006630 Uncharacterized conserved protein [Function unknown]; Region: COG4717 1114967006631 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1114967006632 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 1114967006633 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114967006634 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1114967006635 WHG domain; Region: WHG; pfam13305 1114967006636 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1114967006637 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1114967006638 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114967006639 catalytic residue [active] 1114967006640 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1114967006641 putative deacylase active site [active] 1114967006642 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1114967006643 NAD synthetase; Reviewed; Region: nadE; PRK02628 1114967006644 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 1114967006645 multimer interface [polypeptide binding]; other site 1114967006646 active site 1114967006647 catalytic triad [active] 1114967006648 protein interface 1 [polypeptide binding]; other site 1114967006649 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1114967006650 homodimer interface [polypeptide binding]; other site 1114967006651 NAD binding pocket [chemical binding]; other site 1114967006652 ATP binding pocket [chemical binding]; other site 1114967006653 Mg binding site [ion binding]; other site 1114967006654 active-site loop [active] 1114967006655 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 1114967006656 6-phosphofructokinase, eukaryotic type; Region: 6PF1K_euk; TIGR02478 1114967006657 active site 1114967006658 ADP/pyrophosphate binding site [chemical binding]; other site 1114967006659 dimerization interface [polypeptide binding]; other site 1114967006660 allosteric effector site; other site 1114967006661 fructose-1,6-bisphosphate binding site; other site 1114967006662 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1114967006663 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1114967006664 hexamer interface [polypeptide binding]; other site 1114967006665 ligand binding site [chemical binding]; other site 1114967006666 putative active site [active] 1114967006667 NAD(P) binding site [chemical binding]; other site 1114967006668 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 1114967006669 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 1114967006670 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1114967006671 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1114967006672 Bacterial SH3 domain; Region: SH3_3; pfam08239 1114967006673 Bacterial SH3 domain; Region: SH3_3; pfam08239 1114967006674 Bacterial SH3 domain; Region: SH3_4; pfam06347 1114967006675 Bacterial SH3 domain; Region: SH3_4; pfam06347 1114967006676 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 1114967006677 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1114967006678 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1114967006679 dimer interface [polypeptide binding]; other site 1114967006680 Citrate synthase; Region: Citrate_synt; pfam00285 1114967006681 active site 1114967006682 citrylCoA binding site [chemical binding]; other site 1114967006683 NADH binding [chemical binding]; other site 1114967006684 cationic pore residues; other site 1114967006685 oxalacetate/citrate binding site [chemical binding]; other site 1114967006686 coenzyme A binding site [chemical binding]; other site 1114967006687 catalytic triad [active] 1114967006688 adenosine deaminase; Provisional; Region: PRK09358 1114967006689 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1114967006690 active site 1114967006691 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1114967006692 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1114967006693 hexamer interface [polypeptide binding]; other site 1114967006694 ligand binding site [chemical binding]; other site 1114967006695 putative active site [active] 1114967006696 NAD(P) binding site [chemical binding]; other site 1114967006697 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1114967006698 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1114967006699 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1114967006700 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1114967006701 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1114967006702 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 1114967006703 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1114967006704 catalytic residue [active] 1114967006705 D-Lysine 5,6-aminomutase alpha subunit; Region: Lys-AminoMut_A; pfam09043 1114967006706 D-Lysine 5,6-aminomutase alpha subunit; Region: Lys-AminoMut_A; pfam09043 1114967006707 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1114967006708 B12 binding site [chemical binding]; other site 1114967006709 MutL protein; Region: MutL; pfam13941 1114967006710 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 1114967006711 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815 1114967006712 active site 1114967006713 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1114967006714 dimer interface [polypeptide binding]; other site 1114967006715 substrate binding site [chemical binding]; other site 1114967006716 catalytic residue [active] 1114967006717 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 1114967006718 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 1114967006719 alanine racemase; Reviewed; Region: alr; PRK00053 1114967006720 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1114967006721 active site 1114967006722 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1114967006723 dimer interface [polypeptide binding]; other site 1114967006724 substrate binding site [chemical binding]; other site 1114967006725 catalytic residues [active] 1114967006726 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1114967006727 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 1114967006728 active site 1114967006729 substrate binding site [chemical binding]; other site 1114967006730 metal binding site [ion binding]; metal-binding site 1114967006731 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1114967006732 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 1114967006733 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1114967006734 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 1114967006735 active site 1114967006736 Substrate binding site; other site 1114967006737 Mg++ binding site; other site 1114967006738 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1114967006739 putative active site [active] 1114967006740 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1114967006741 Class II fumarases; Region: Fumarase_classII; cd01362 1114967006742 active site 1114967006743 tetramer interface [polypeptide binding]; other site 1114967006744 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1114967006745 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114967006746 dimer interface [polypeptide binding]; other site 1114967006747 conserved gate region; other site 1114967006748 putative PBP binding loops; other site 1114967006749 ABC-ATPase subunit interface; other site 1114967006750 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114967006751 dimer interface [polypeptide binding]; other site 1114967006752 conserved gate region; other site 1114967006753 putative PBP binding loops; other site 1114967006754 ABC-ATPase subunit interface; other site 1114967006755 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1114967006756 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1114967006757 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1114967006758 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1114967006759 DNA binding site [nucleotide binding] 1114967006760 domain linker motif; other site 1114967006761 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 1114967006762 putative dimerization interface [polypeptide binding]; other site 1114967006763 putative ligand binding site [chemical binding]; other site 1114967006764 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 1114967006765 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1114967006766 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1114967006767 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1114967006768 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1114967006769 Walker A/P-loop; other site 1114967006770 ATP binding site [chemical binding]; other site 1114967006771 Q-loop/lid; other site 1114967006772 ABC transporter signature motif; other site 1114967006773 Walker B; other site 1114967006774 D-loop; other site 1114967006775 H-loop/switch region; other site 1114967006776 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1114967006777 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1114967006778 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1114967006779 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1114967006780 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1114967006781 acyl-activating enzyme (AAE) consensus motif; other site 1114967006782 acyl-activating enzyme (AAE) consensus motif; other site 1114967006783 AMP binding site [chemical binding]; other site 1114967006784 active site 1114967006785 CoA binding site [chemical binding]; other site 1114967006786 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1114967006787 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1114967006788 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1114967006789 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114967006790 homodimer interface [polypeptide binding]; other site 1114967006791 catalytic residue [active] 1114967006792 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 1114967006793 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 1114967006794 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 1114967006795 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1114967006796 dimer interface [polypeptide binding]; other site 1114967006797 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114967006798 catalytic residue [active] 1114967006799 2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944 1114967006800 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1114967006801 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114967006802 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1114967006803 NAD(P) binding site [chemical binding]; other site 1114967006804 active site 1114967006805 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114967006806 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1114967006807 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114967006808 Coenzyme A binding pocket [chemical binding]; other site 1114967006809 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 1114967006810 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1114967006811 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1114967006812 dimer interface [polypeptide binding]; other site 1114967006813 active site 1114967006814 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1114967006815 active site 1114967006816 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114967006817 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114967006818 putative substrate translocation pore; other site 1114967006819 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 1114967006820 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1114967006821 active site 1114967006822 ATP binding site [chemical binding]; other site 1114967006823 substrate binding site [chemical binding]; other site 1114967006824 activation loop (A-loop); other site 1114967006825 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 1114967006826 active site 1114967006827 zinc binding site [ion binding]; other site 1114967006828 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1114967006829 Histidine kinase; Region: HisKA_3; pfam07730 1114967006830 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1114967006831 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114967006832 active site 1114967006833 phosphorylation site [posttranslational modification] 1114967006834 intermolecular recognition site; other site 1114967006835 dimerization interface [polypeptide binding]; other site 1114967006836 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1114967006837 DNA binding residues [nucleotide binding] 1114967006838 dimerization interface [polypeptide binding]; other site 1114967006839 Glycerate kinase family; Region: Gly_kinase; cl00841 1114967006840 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 1114967006841 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1114967006842 active site 1114967006843 NTP binding site [chemical binding]; other site 1114967006844 metal binding triad [ion binding]; metal-binding site 1114967006845 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1114967006846 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1114967006847 Zn2+ binding site [ion binding]; other site 1114967006848 Mg2+ binding site [ion binding]; other site 1114967006849 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1114967006850 ATP binding site [chemical binding]; other site 1114967006851 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1114967006852 glycerol kinase; Provisional; Region: glpK; PRK00047 1114967006853 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 1114967006854 N- and C-terminal domain interface [polypeptide binding]; other site 1114967006855 active site 1114967006856 MgATP binding site [chemical binding]; other site 1114967006857 catalytic site [active] 1114967006858 metal binding site [ion binding]; metal-binding site 1114967006859 putative homotetramer interface [polypeptide binding]; other site 1114967006860 glycerol binding site [chemical binding]; other site 1114967006861 homodimer interface [polypeptide binding]; other site 1114967006862 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 1114967006863 amphipathic channel; other site 1114967006864 Asn-Pro-Ala signature motifs; other site 1114967006865 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1114967006866 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1114967006867 DNA binding residues [nucleotide binding] 1114967006868 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1114967006869 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1114967006870 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1114967006871 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 1114967006872 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1114967006873 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1114967006874 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1114967006875 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 1114967006876 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1114967006877 probable active site [active] 1114967006878 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114967006879 putative substrate translocation pore; other site 1114967006880 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1114967006881 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1114967006882 substrate binding pocket [chemical binding]; other site 1114967006883 OsmC-like protein; Region: OsmC; pfam02566 1114967006884 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1114967006885 catalytic residues [active] 1114967006886 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1114967006887 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1114967006888 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1114967006889 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1114967006890 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 1114967006891 non-specific DNA interactions [nucleotide binding]; other site 1114967006892 DNA binding site [nucleotide binding] 1114967006893 sequence specific DNA binding site [nucleotide binding]; other site 1114967006894 putative cAMP binding site [chemical binding]; other site 1114967006895 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1114967006896 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1114967006897 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1114967006898 TPP-binding site [chemical binding]; other site 1114967006899 dimer interface [polypeptide binding]; other site 1114967006900 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1114967006901 PYR/PP interface [polypeptide binding]; other site 1114967006902 dimer interface [polypeptide binding]; other site 1114967006903 TPP binding site [chemical binding]; other site 1114967006904 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1114967006905 ribulokinase; Provisional; Region: PRK04123 1114967006906 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 1114967006907 N- and C-terminal domain interface [polypeptide binding]; other site 1114967006908 active site 1114967006909 MgATP binding site [chemical binding]; other site 1114967006910 catalytic site [active] 1114967006911 metal binding site [ion binding]; metal-binding site 1114967006912 carbohydrate binding site [chemical binding]; other site 1114967006913 homodimer interface [polypeptide binding]; other site 1114967006914 Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175 1114967006915 active site 1114967006916 metal binding site [ion binding]; metal-binding site 1114967006917 Carbohydrate kinase and ribulose-phosphate 3-epimerase fusion proteins-like; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CarbK-RPE_like; cd07783 1114967006918 Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069 1114967006919 N- and C-terminal domain interface [polypeptide binding]; other site 1114967006920 active site 1114967006921 MgATP binding site [chemical binding]; other site 1114967006922 catalytic site [active] 1114967006923 metal binding site [ion binding]; metal-binding site 1114967006924 putative carbohydrate binding site [chemical binding]; other site 1114967006925 putative homodimer interface [polypeptide binding]; other site 1114967006926 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1114967006927 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114967006928 active site 1114967006929 motif I; other site 1114967006930 motif II; other site 1114967006931 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114967006932 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 1114967006933 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 1114967006934 active site 1114967006935 Zn2+ binding site [ion binding]; other site 1114967006936 intersubunit interface [polypeptide binding]; other site 1114967006937 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1114967006938 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1114967006939 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1114967006940 mannonate dehydratase; Provisional; Region: PRK03906 1114967006941 mannonate dehydratase; Region: uxuA; TIGR00695 1114967006942 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1114967006943 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1114967006944 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1114967006945 glucuronate isomerase; Reviewed; Region: PRK02925 1114967006946 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 1114967006947 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1114967006948 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1114967006949 DNA binding site [nucleotide binding] 1114967006950 domain linker motif; other site 1114967006951 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1114967006952 dimerization interface [polypeptide binding]; other site 1114967006953 ligand binding site [chemical binding]; other site 1114967006954 MFS/sugar transport protein; Region: MFS_2; pfam13347 1114967006955 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1114967006956 putative alpha-glucosidase; Provisional; Region: PRK10658 1114967006957 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1114967006958 Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599 1114967006959 putative active site [active] 1114967006960 putative catalytic site [active] 1114967006961 beta-D-glucuronidase; Provisional; Region: PRK10150 1114967006962 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1114967006963 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1114967006964 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1114967006965 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 1114967006966 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1114967006967 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1114967006968 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114967006969 homodimer interface [polypeptide binding]; other site 1114967006970 catalytic residue [active] 1114967006971 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 1114967006972 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1114967006973 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1114967006974 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 1114967006975 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 1114967006976 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1114967006977 ParB-like nuclease domain; Region: ParB; smart00470 1114967006978 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1114967006979 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1114967006980 P-loop; other site 1114967006981 Magnesium ion binding site [ion binding]; other site 1114967006982 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1114967006983 Magnesium ion binding site [ion binding]; other site 1114967006984 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 1114967006985 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 1114967006986 Alanine racemase, N-terminal domain; Region: Ala_racemase_N; pfam01168 1114967006987 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1114967006988 catalytic residue [active] 1114967006989 FemAB family; Region: FemAB; pfam02388 1114967006990 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1114967006991 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 1114967006992 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1114967006993 G-X-X-G motif; other site 1114967006994 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1114967006995 RxxxH motif; other site 1114967006996 putative inner membrane protein translocase component YidC; Provisional; Region: PRK01315 1114967006997 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1114967006998 Ribonuclease P; Region: Ribonuclease_P; cl00457 1114967006999 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399