-- dump date 20140620_001104 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1114966000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1114966000002 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 1114966000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114966000004 Walker A motif; other site 1114966000005 ATP binding site [chemical binding]; other site 1114966000006 Walker B motif; other site 1114966000007 arginine finger; other site 1114966000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1114966000009 DnaA box-binding interface [nucleotide binding]; other site 1114966000010 DNA polymerase III subunit beta; Validated; Region: PRK07761 1114966000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1114966000012 putative DNA binding surface [nucleotide binding]; other site 1114966000013 dimer interface [polypeptide binding]; other site 1114966000014 beta-clamp/clamp loader binding surface; other site 1114966000015 beta-clamp/translesion DNA polymerase binding surface; other site 1114966000016 recombination protein F; Reviewed; Region: recF; PRK00064 1114966000017 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114966000018 Walker A/P-loop; other site 1114966000019 ATP binding site [chemical binding]; other site 1114966000020 Q-loop/lid; other site 1114966000021 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114966000022 ABC transporter signature motif; other site 1114966000023 Walker B; other site 1114966000024 D-loop; other site 1114966000025 H-loop/switch region; other site 1114966000026 Protein of unknown function (DUF721); Region: DUF721; cl02324 1114966000027 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114966000028 ABC transporter signature motif; other site 1114966000029 Walker B; other site 1114966000030 D-loop; other site 1114966000031 H-loop/switch region; other site 1114966000032 potential frameshift: common BLAST hit: gi|29375676|ref|NP_814830.1| ABC transporter ATP-binding protein/permease 1114966000033 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 1114966000034 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 1114966000035 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1114966000036 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1114966000037 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1114966000038 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114966000039 Mg2+ binding site [ion binding]; other site 1114966000040 G-X-G motif; other site 1114966000041 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1114966000042 anchoring element; other site 1114966000043 dimer interface [polypeptide binding]; other site 1114966000044 ATP binding site [chemical binding]; other site 1114966000045 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1114966000046 active site 1114966000047 putative metal-binding site [ion binding]; other site 1114966000048 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1114966000049 DNA gyrase subunit A; Validated; Region: PRK05560 1114966000050 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1114966000051 CAP-like domain; other site 1114966000052 active site 1114966000053 primary dimer interface [polypeptide binding]; other site 1114966000054 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1114966000055 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1114966000056 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1114966000057 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1114966000058 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1114966000059 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 1114966000060 A subgroup of L-lactate dehydrogenases; Region: LDH_3; cd05290 1114966000061 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 1114966000062 NAD binding site [chemical binding]; other site 1114966000063 dimer interface [polypeptide binding]; other site 1114966000064 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1114966000065 substrate binding site [chemical binding]; other site 1114966000066 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1114966000067 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1114966000068 DNA binding site [nucleotide binding] 1114966000069 domain linker motif; other site 1114966000070 Ligand-binding domain of DNA-binding regulatory protein from Corynebacterium glutamicum which has a unique ability to produce significant amounts of L-glutamate directly from cheap sugar and ammonia; Region: PBP1_LacI_like_13; cd06299 1114966000071 dimerization interface [polypeptide binding]; other site 1114966000072 putative ligand binding site [chemical binding]; other site 1114966000073 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1114966000074 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1114966000075 Walker A/P-loop; other site 1114966000076 ATP binding site [chemical binding]; other site 1114966000077 Q-loop/lid; other site 1114966000078 ABC transporter signature motif; other site 1114966000079 Walker B; other site 1114966000080 D-loop; other site 1114966000081 H-loop/switch region; other site 1114966000082 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1114966000083 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1114966000084 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1114966000085 TM-ABC transporter signature motif; other site 1114966000086 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 1114966000087 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1114966000088 ligand binding site [chemical binding]; other site 1114966000089 dimerization interface [polypeptide binding]; other site 1114966000090 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1114966000091 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1114966000092 substrate binding site [chemical binding]; other site 1114966000093 dimer interface [polypeptide binding]; other site 1114966000094 ATP binding site [chemical binding]; other site 1114966000095 D-ribose pyranase; Provisional; Region: PRK11797 1114966000096 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1114966000097 active site 1114966000098 phosphorylation site [posttranslational modification] 1114966000099 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 1114966000100 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 1114966000101 active site 1114966000102 P-loop; other site 1114966000103 phosphorylation site [posttranslational modification] 1114966000104 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1114966000105 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1114966000106 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1114966000107 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1114966000108 HTH domain; Region: HTH_11; cl17392 1114966000109 PRD domain; Region: PRD; pfam00874 1114966000110 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1114966000111 active site 1114966000112 phosphorylation site [posttranslational modification] 1114966000113 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1114966000114 haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549 1114966000115 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1114966000116 active site 1114966000117 motif I; other site 1114966000118 motif II; other site 1114966000119 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1114966000120 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1114966000121 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1114966000122 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 1114966000123 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1114966000124 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114966000125 homodimer interface [polypeptide binding]; other site 1114966000126 catalytic residue [active] 1114966000127 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 1114966000128 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 1114966000129 active site 1114966000130 nucleophile elbow; other site 1114966000131 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1114966000132 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1114966000133 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 1114966000134 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 1114966000135 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1114966000136 Walker A motif; other site 1114966000137 ATP binding site [chemical binding]; other site 1114966000138 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1114966000139 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1114966000140 Bacterial transcriptional activator domain; Region: BTAD; smart01043 1114966000141 H+ Antiporter protein; Region: 2A0121; TIGR00900 1114966000142 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 1114966000143 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 1114966000144 Potassium binding sites [ion binding]; other site 1114966000145 Cesium cation binding sites [ion binding]; other site 1114966000146 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 1114966000147 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1114966000148 FtsX-like permease family; Region: FtsX; pfam02687 1114966000149 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1114966000150 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1114966000151 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1114966000152 Walker A/P-loop; other site 1114966000153 ATP binding site [chemical binding]; other site 1114966000154 Q-loop/lid; other site 1114966000155 ABC transporter signature motif; other site 1114966000156 Walker B; other site 1114966000157 D-loop; other site 1114966000158 H-loop/switch region; other site 1114966000159 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1114966000160 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114966000161 active site 1114966000162 phosphorylation site [posttranslational modification] 1114966000163 intermolecular recognition site; other site 1114966000164 dimerization interface [polypeptide binding]; other site 1114966000165 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1114966000166 DNA binding residues [nucleotide binding] 1114966000167 dimerization interface [polypeptide binding]; other site 1114966000168 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1114966000169 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114966000170 dimer interface [polypeptide binding]; other site 1114966000171 conserved gate region; other site 1114966000172 putative PBP binding loops; other site 1114966000173 ABC-ATPase subunit interface; other site 1114966000174 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114966000175 dimer interface [polypeptide binding]; other site 1114966000176 conserved gate region; other site 1114966000177 putative PBP binding loops; other site 1114966000178 ABC-ATPase subunit interface; other site 1114966000179 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1114966000180 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1114966000181 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1114966000182 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1114966000183 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1114966000184 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1114966000185 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 1114966000186 NAD binding site [chemical binding]; other site 1114966000187 sugar binding site [chemical binding]; other site 1114966000188 divalent metal binding site [ion binding]; other site 1114966000189 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1114966000190 dimer interface [polypeptide binding]; other site 1114966000191 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 1114966000192 active site 1114966000193 catalytic site [active] 1114966000194 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 1114966000195 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 1114966000196 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 1114966000197 Sulfatase; Region: Sulfatase; cl17466 1114966000198 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 1114966000199 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114966000200 motif II; other site 1114966000201 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 1114966000202 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 1114966000203 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 1114966000204 active site 1114966000205 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1114966000206 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1114966000207 substrate binding site [chemical binding]; other site 1114966000208 ATP binding site [chemical binding]; other site 1114966000209 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1114966000210 Histidine kinase; Region: HisKA_3; pfam07730 1114966000211 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114966000212 ATP binding site [chemical binding]; other site 1114966000213 Mg2+ binding site [ion binding]; other site 1114966000214 G-X-G motif; other site 1114966000215 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1114966000216 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114966000217 NAD(P) binding site [chemical binding]; other site 1114966000218 active site 1114966000219 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114966000220 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1114966000221 MMPL family; Region: MMPL; pfam03176 1114966000222 MMPL family; Region: MMPL; pfam03176 1114966000223 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1114966000224 Predicted membrane protein [Function unknown]; Region: COG1511 1114966000225 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1114966000226 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1114966000227 Walker A/P-loop; other site 1114966000228 ATP binding site [chemical binding]; other site 1114966000229 Q-loop/lid; other site 1114966000230 ABC transporter signature motif; other site 1114966000231 Walker B; other site 1114966000232 D-loop; other site 1114966000233 H-loop/switch region; other site 1114966000234 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114966000235 S-adenosylmethionine binding site [chemical binding]; other site 1114966000236 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 1114966000237 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 1114966000238 putative ligand binding residues [chemical binding]; other site 1114966000239 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1114966000240 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1114966000241 ABC-ATPase subunit interface; other site 1114966000242 dimer interface [polypeptide binding]; other site 1114966000243 putative PBP binding regions; other site 1114966000244 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1114966000245 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114966000246 Walker B; other site 1114966000247 D-loop; other site 1114966000248 H-loop/switch region; other site 1114966000249 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1114966000250 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1114966000251 tetramerization interface [polypeptide binding]; other site 1114966000252 NAD(P) binding site [chemical binding]; other site 1114966000253 catalytic residues [active] 1114966000254 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1114966000255 Putative ClC chloride channel. Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033 1114966000256 putative ion selectivity filter; other site 1114966000257 putative pore gating glutamate residue; other site 1114966000258 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1114966000259 homodimer interface [polypeptide binding]; other site 1114966000260 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 1114966000261 active site pocket [active] 1114966000262 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1114966000263 DNA binding residues [nucleotide binding] 1114966000264 potential frameshift: common BLAST hit: gi|295129613|ref|YP_003580276.1| 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase 1114966000265 MarR family; Region: MarR_2; pfam12802 1114966000266 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1114966000267 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1114966000268 carbohydrate ABC transporter substrate-binding protein, CPR_0540 family; Region: bind_CPR_0540; TIGR03850 1114966000269 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1114966000270 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1114966000271 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114966000272 dimer interface [polypeptide binding]; other site 1114966000273 conserved gate region; other site 1114966000274 putative PBP binding loops; other site 1114966000275 ABC-ATPase subunit interface; other site 1114966000276 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1114966000277 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114966000278 dimer interface [polypeptide binding]; other site 1114966000279 conserved gate region; other site 1114966000280 putative PBP binding loops; other site 1114966000281 ABC-ATPase subunit interface; other site 1114966000282 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1114966000283 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1114966000284 DNA binding site [nucleotide binding] 1114966000285 domain linker motif; other site 1114966000286 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 1114966000287 ligand binding site [chemical binding]; other site 1114966000288 dimerization interface (open form) [polypeptide binding]; other site 1114966000289 dimerization interface (closed form) [polypeptide binding]; other site 1114966000290 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1114966000291 6-phosphofructokinase; Provisional; Region: PRK03202 1114966000292 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1114966000293 active site 1114966000294 ADP/pyrophosphate binding site [chemical binding]; other site 1114966000295 dimerization interface [polypeptide binding]; other site 1114966000296 allosteric effector site; other site 1114966000297 fructose-1,6-bisphosphate binding site; other site 1114966000298 Predicted transcriptional regulator [Transcription]; Region: COG2345 1114966000299 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1114966000300 putative DNA binding site [nucleotide binding]; other site 1114966000301 putative Zn2+ binding site [ion binding]; other site 1114966000302 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 1114966000303 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 1114966000304 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1114966000305 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1114966000306 Aspartase; Region: Aspartase; cd01357 1114966000307 active sites [active] 1114966000308 tetramer interface [polypeptide binding]; other site 1114966000309 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 1114966000310 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 1114966000311 Predicted acetyltransferase [General function prediction only]; Region: COG2388 1114966000312 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1114966000313 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 1114966000314 heme binding pocket [chemical binding]; other site 1114966000315 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1114966000316 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1114966000317 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114966000318 Walker A/P-loop; other site 1114966000319 ATP binding site [chemical binding]; other site 1114966000320 Q-loop/lid; other site 1114966000321 ABC transporter signature motif; other site 1114966000322 Walker B; other site 1114966000323 D-loop; other site 1114966000324 H-loop/switch region; other site 1114966000325 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1114966000326 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1114966000327 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114966000328 Q-loop/lid; other site 1114966000329 ABC transporter signature motif; other site 1114966000330 Walker B; other site 1114966000331 D-loop; other site 1114966000332 H-loop/switch region; other site 1114966000333 Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081 1114966000334 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1114966000335 Walker A motif; other site 1114966000336 ATP binding site [chemical binding]; other site 1114966000337 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 1114966000338 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1114966000339 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 1114966000340 metal ion-dependent adhesion site (MIDAS); other site 1114966000341 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1114966000342 CobN/Magnesium Chelatase; Region: CobN-Mg_chel; pfam02514 1114966000343 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1114966000344 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1114966000345 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1114966000346 FeS/SAM binding site; other site 1114966000347 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1114966000348 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1114966000349 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1114966000350 Walker A/P-loop; other site 1114966000351 ATP binding site [chemical binding]; other site 1114966000352 Q-loop/lid; other site 1114966000353 ABC transporter signature motif; other site 1114966000354 Walker B; other site 1114966000355 D-loop; other site 1114966000356 H-loop/switch region; other site 1114966000357 FecCD transport family; Region: FecCD; pfam01032 1114966000358 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1114966000359 ABC-ATPase subunit interface; other site 1114966000360 dimer interface [polypeptide binding]; other site 1114966000361 putative PBP binding regions; other site 1114966000362 Periplasmic binding protein TroA_d. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_d; cd01141 1114966000363 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1114966000364 putative ligand binding site [chemical binding]; other site 1114966000365 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1114966000366 Periplasmic binding protein TroA_d. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_d; cd01141 1114966000367 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1114966000368 putative ligand binding site [chemical binding]; other site 1114966000369 myosin-cross-reactive antigen; Provisional; Region: PRK13977 1114966000370 multifunctional hydroxymethylpyrimidine phosphokinase/4-amino-5-aminomethyl-2-methylpyrimidine hydrolase; Provisional; Region: PRK14713 1114966000371 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1114966000372 dimer interface [polypeptide binding]; other site 1114966000373 substrate binding site [chemical binding]; other site 1114966000374 ATP binding site [chemical binding]; other site 1114966000375 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 1114966000376 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1114966000377 thiamine phosphate binding site [chemical binding]; other site 1114966000378 active site 1114966000379 pyrophosphate binding site [ion binding]; other site 1114966000380 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1114966000381 putative active site [active] 1114966000382 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 1114966000383 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 1114966000384 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1114966000385 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1114966000386 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 1114966000387 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1114966000388 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1114966000389 Ligand Binding Site [chemical binding]; other site 1114966000390 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114966000391 dimer interface [polypeptide binding]; other site 1114966000392 phosphorylation site [posttranslational modification] 1114966000393 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114966000394 ATP binding site [chemical binding]; other site 1114966000395 Mg2+ binding site [ion binding]; other site 1114966000396 G-X-G motif; other site 1114966000397 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1114966000398 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114966000399 active site 1114966000400 phosphorylation site [posttranslational modification] 1114966000401 intermolecular recognition site; other site 1114966000402 dimerization interface [polypeptide binding]; other site 1114966000403 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1114966000404 DNA binding site [nucleotide binding] 1114966000405 EXLDI protein; Region: EXLDI; TIGR04342 1114966000406 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1114966000407 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1114966000408 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1114966000409 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1114966000410 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1114966000411 Transglycosylase; Region: Transgly; pfam00912 1114966000412 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1114966000413 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1114966000414 Mannosyltransferase (PIG-V)); Region: Mannosyl_trans2; pfam04188 1114966000415 potential frameshift: common BLAST hit: gi|295129669|ref|YP_003580332.1| glycosyltransferase, group 1 family protein 1114966000416 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1114966000417 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1114966000418 O-Antigen ligase; Region: Wzy_C; pfam04932 1114966000419 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 1114966000420 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1114966000421 putative trimer interface [polypeptide binding]; other site 1114966000422 putative CoA binding site [chemical binding]; other site 1114966000423 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 1114966000424 putative trimer interface [polypeptide binding]; other site 1114966000425 putative active site [active] 1114966000426 putative substrate binding site [chemical binding]; other site 1114966000427 putative CoA binding site [chemical binding]; other site 1114966000428 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1114966000429 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1114966000430 inhibitor-cofactor binding pocket; inhibition site 1114966000431 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114966000432 catalytic residue [active] 1114966000433 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1114966000434 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1114966000435 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1114966000436 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 1114966000437 O-Antigen ligase; Region: Wzy_C; pfam04932 1114966000438 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1114966000439 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114966000440 POT family; Region: PTR2; cl17359 1114966000441 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1114966000442 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1114966000443 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1114966000444 classical (c) SDRs; Region: SDR_c; cd05233 1114966000445 NAD(P) binding site [chemical binding]; other site 1114966000446 active site 1114966000447 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1114966000448 dimerization domain swap beta strand [polypeptide binding]; other site 1114966000449 regulatory protein interface [polypeptide binding]; other site 1114966000450 active site 1114966000451 regulatory phosphorylation site [posttranslational modification]; other site 1114966000452 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1114966000453 active site 1114966000454 phosphorylation site [posttranslational modification] 1114966000455 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1114966000456 active site 1114966000457 P-loop; other site 1114966000458 phosphorylation site [posttranslational modification] 1114966000459 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1114966000460 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1114966000461 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1114966000462 putative substrate binding site [chemical binding]; other site 1114966000463 putative ATP binding site [chemical binding]; other site 1114966000464 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1114966000465 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1114966000466 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1114966000467 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 1114966000468 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1114966000469 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1114966000470 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1114966000471 O-Antigen ligase; Region: Wzy_C; pfam04932 1114966000472 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1114966000473 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 1114966000474 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1114966000475 active site 1114966000476 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 1114966000477 homodimer interface [polypeptide binding]; other site 1114966000478 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1114966000479 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1114966000480 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1114966000481 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1114966000482 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1114966000483 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 1114966000484 nudix motif; other site 1114966000485 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 1114966000486 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1114966000487 ATP binding site [chemical binding]; other site 1114966000488 putative Mg++ binding site [ion binding]; other site 1114966000489 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1114966000490 nucleotide binding region [chemical binding]; other site 1114966000491 ATP-binding site [chemical binding]; other site 1114966000492 Helicase associated domain (HA2); Region: HA2; pfam04408 1114966000493 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 1114966000494 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 1114966000495 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1114966000496 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1114966000497 Walker A/P-loop; other site 1114966000498 ATP binding site [chemical binding]; other site 1114966000499 Q-loop/lid; other site 1114966000500 ABC transporter signature motif; other site 1114966000501 Walker B; other site 1114966000502 D-loop; other site 1114966000503 H-loop/switch region; other site 1114966000504 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114966000505 Walker A/P-loop; other site 1114966000506 ATP binding site [chemical binding]; other site 1114966000507 Q-loop/lid; other site 1114966000508 ABC transporter signature motif; other site 1114966000509 Walker B; other site 1114966000510 D-loop; other site 1114966000511 H-loop/switch region; other site 1114966000512 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1114966000513 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1114966000514 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 1114966000515 Predicted membrane protein [Function unknown]; Region: COG4270 1114966000516 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565 1114966000517 Dihydroorotate dehydrogenase (DHOD) like proteins. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_like; cd04739 1114966000518 putative active site [active] 1114966000519 putative FMN binding site [chemical binding]; other site 1114966000520 putative substrate binding site [chemical binding]; other site 1114966000521 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 1114966000522 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1114966000523 dimer interface [polypeptide binding]; other site 1114966000524 PYR/PP interface [polypeptide binding]; other site 1114966000525 TPP binding site [chemical binding]; other site 1114966000526 substrate binding site [chemical binding]; other site 1114966000527 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1114966000528 Domain of unknown function; Region: EKR; smart00890 1114966000529 4Fe-4S binding domain; Region: Fer4_6; pfam12837 1114966000530 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1114966000531 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 1114966000532 TPP-binding site [chemical binding]; other site 1114966000533 dimer interface [polypeptide binding]; other site 1114966000534 putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771 1114966000535 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1114966000536 4Fe-4S binding domain; Region: Fer4; pfam00037 1114966000537 Domain of unknown function DUF77; Region: DUF77; pfam01910 1114966000538 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1114966000539 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114966000540 DNA-binding site [nucleotide binding]; DNA binding site 1114966000541 FCD domain; Region: FCD; pfam07729 1114966000542 L-lactate permease; Region: Lactate_perm; cl00701 1114966000543 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 1114966000544 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1114966000545 Cysteine-rich domain; Region: CCG; pfam02754 1114966000546 Cysteine-rich domain; Region: CCG; pfam02754 1114966000547 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 1114966000548 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1114966000549 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1114966000550 Uncharacterized conserved protein [Function unknown]; Region: COG1556 1114966000551 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 1114966000552 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1114966000553 Walker A/P-loop; other site 1114966000554 ATP binding site [chemical binding]; other site 1114966000555 Q-loop/lid; other site 1114966000556 ABC transporter signature motif; other site 1114966000557 Walker B; other site 1114966000558 D-loop; other site 1114966000559 H-loop/switch region; other site 1114966000560 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 1114966000561 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1114966000562 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1114966000563 Walker A/P-loop; other site 1114966000564 ATP binding site [chemical binding]; other site 1114966000565 Q-loop/lid; other site 1114966000566 ABC transporter signature motif; other site 1114966000567 Walker B; other site 1114966000568 D-loop; other site 1114966000569 H-loop/switch region; other site 1114966000570 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1114966000571 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1114966000572 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1114966000573 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1114966000574 Amino acid permease; Region: AA_permease_2; pfam13520 1114966000575 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1114966000576 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1114966000577 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1114966000578 Walker A/P-loop; other site 1114966000579 ATP binding site [chemical binding]; other site 1114966000580 Q-loop/lid; other site 1114966000581 ABC transporter signature motif; other site 1114966000582 Walker B; other site 1114966000583 D-loop; other site 1114966000584 H-loop/switch region; other site 1114966000585 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1114966000586 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1114966000587 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114966000588 Walker A/P-loop; other site 1114966000589 ATP binding site [chemical binding]; other site 1114966000590 Q-loop/lid; other site 1114966000591 ABC transporter signature motif; other site 1114966000592 Walker B; other site 1114966000593 D-loop; other site 1114966000594 H-loop/switch region; other site 1114966000595 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1114966000596 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1114966000597 non-specific DNA binding site [nucleotide binding]; other site 1114966000598 salt bridge; other site 1114966000599 sequence-specific DNA binding site [nucleotide binding]; other site 1114966000600 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1114966000601 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1114966000602 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1114966000603 dimer interface [polypeptide binding]; other site 1114966000604 putative anticodon binding site; other site 1114966000605 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1114966000606 motif 1; other site 1114966000607 dimer interface [polypeptide binding]; other site 1114966000608 active site 1114966000609 motif 2; other site 1114966000610 motif 3; other site 1114966000611 Uncharacterized protein family (UPF0233); Region: UPF0233; pfam06781 1114966000612 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1114966000613 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1114966000614 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1114966000615 active site 1114966000616 ATP binding site [chemical binding]; other site 1114966000617 substrate binding site [chemical binding]; other site 1114966000618 activation loop (A-loop); other site 1114966000619 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1114966000620 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1114966000621 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1114966000622 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1114966000623 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 1114966000624 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1114966000625 active site 1114966000626 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1114966000627 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1114966000628 phosphopeptide binding site; other site 1114966000629 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 1114966000630 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1114966000631 phosphopeptide binding site; other site 1114966000632 Phosphotransferase enzyme family; Region: APH; pfam01636 1114966000633 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1114966000634 active site 1114966000635 ATP binding site [chemical binding]; other site 1114966000636 RHS Repeat; Region: RHS_repeat; cl11982 1114966000637 RHS Repeat; Region: RHS_repeat; pfam05593 1114966000638 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1114966000639 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 1114966000640 RHS Repeat; Region: RHS_repeat; pfam05593 1114966000641 RHS Repeat; Region: RHS_repeat; pfam05593 1114966000642 RHS Repeat; Region: RHS_repeat; pfam05593 1114966000643 RHS Repeat; Region: RHS_repeat; cl11982 1114966000644 RHS Repeat; Region: RHS_repeat; cl11982 1114966000645 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 1114966000646 RHS Repeat; Region: RHS_repeat; pfam05593 1114966000647 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1114966000648 RNA binding surface [nucleotide binding]; other site 1114966000649 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 1114966000650 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114966000651 Walker A motif; other site 1114966000652 ATP binding site [chemical binding]; other site 1114966000653 Walker B motif; other site 1114966000654 arginine finger; other site 1114966000655 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1114966000656 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG0718 1114966000657 recombination protein RecR; Reviewed; Region: recR; PRK00076 1114966000658 RecR protein; Region: RecR; pfam02132 1114966000659 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1114966000660 putative active site [active] 1114966000661 putative metal-binding site [ion binding]; other site 1114966000662 tetramer interface [polypeptide binding]; other site 1114966000663 Predicted transcriptional regulators [Transcription]; Region: COG1695 1114966000664 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1114966000665 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1114966000666 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1114966000667 Walker A/P-loop; other site 1114966000668 ATP binding site [chemical binding]; other site 1114966000669 Q-loop/lid; other site 1114966000670 ABC transporter signature motif; other site 1114966000671 Walker B; other site 1114966000672 D-loop; other site 1114966000673 H-loop/switch region; other site 1114966000674 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1114966000675 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1114966000676 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1114966000677 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 1114966000678 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1114966000679 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114966000680 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1114966000681 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114966000682 active site 1114966000683 motif I; other site 1114966000684 motif II; other site 1114966000685 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1114966000686 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114966000687 Q-loop/lid; other site 1114966000688 ABC transporter signature motif; other site 1114966000689 Walker B; other site 1114966000690 D-loop; other site 1114966000691 H-loop/switch region; other site 1114966000692 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 1114966000693 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1114966000694 active site 1114966000695 HIGH motif; other site 1114966000696 nucleotide binding site [chemical binding]; other site 1114966000697 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1114966000698 active site 1114966000699 KMSKS motif; other site 1114966000700 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 1114966000701 tRNA binding surface [nucleotide binding]; other site 1114966000702 anticodon binding site; other site 1114966000703 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 1114966000704 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1114966000705 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 1114966000706 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1114966000707 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1114966000708 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1114966000709 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 1114966000710 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 1114966000711 homotrimer interaction site [polypeptide binding]; other site 1114966000712 putative active site [active] 1114966000713 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1114966000714 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1114966000715 ligand binding site [chemical binding]; other site 1114966000716 flexible hinge region; other site 1114966000717 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1114966000718 putative switch regulator; other site 1114966000719 non-specific DNA interactions [nucleotide binding]; other site 1114966000720 DNA binding site [nucleotide binding] 1114966000721 sequence specific DNA binding site [nucleotide binding]; other site 1114966000722 putative cAMP binding site [chemical binding]; other site 1114966000723 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1114966000724 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1114966000725 minor groove reading motif; other site 1114966000726 helix-hairpin-helix signature motif; other site 1114966000727 substrate binding pocket [chemical binding]; other site 1114966000728 active site 1114966000729 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1114966000730 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1114966000731 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1114966000732 catalytic residues [active] 1114966000733 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1114966000734 putative active site [active] 1114966000735 putative CoA binding site [chemical binding]; other site 1114966000736 nudix motif; other site 1114966000737 metal binding site [ion binding]; metal-binding site 1114966000738 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 1114966000739 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1114966000740 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 1114966000741 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 1114966000742 helicase/secretion neighborhood ATPase; Region: heli_sec_ATPase; TIGR03819 1114966000743 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 1114966000744 Walker A motif; other site 1114966000745 ATP binding site [chemical binding]; other site 1114966000746 Walker B motif; other site 1114966000747 potential frameshift: common BLAST hit: gi|295129802|ref|YP_003580465.1| type II secretion system F domain protein 1114966000748 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 1114966000749 helicase/secretion neighborhood TadE-like protein; Region: tadE_like_DECH; TIGR03816 1114966000750 Predicted ATPase [General function prediction only]; Region: COG4637 1114966000751 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 1114966000752 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1114966000753 ATP binding site [chemical binding]; other site 1114966000754 putative Mg++ binding site [ion binding]; other site 1114966000755 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1114966000756 nucleotide binding region [chemical binding]; other site 1114966000757 ATP-binding site [chemical binding]; other site 1114966000758 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1114966000759 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 1114966000760 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114966000761 S-adenosylmethionine binding site [chemical binding]; other site 1114966000762 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 1114966000763 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1114966000764 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1114966000765 active site 1114966000766 interdomain interaction site; other site 1114966000767 putative metal-binding site [ion binding]; other site 1114966000768 nucleotide binding site [chemical binding]; other site 1114966000769 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1114966000770 domain I; other site 1114966000771 DNA binding groove [nucleotide binding] 1114966000772 phosphate binding site [ion binding]; other site 1114966000773 domain II; other site 1114966000774 domain III; other site 1114966000775 nucleotide binding site [chemical binding]; other site 1114966000776 catalytic site [active] 1114966000777 domain IV; other site 1114966000778 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1114966000779 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1114966000780 thymidylate kinase; Validated; Region: tmk; PRK00698 1114966000781 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1114966000782 TMP-binding site; other site 1114966000783 ATP-binding site [chemical binding]; other site 1114966000784 DNA polymerase III subunit delta'; Validated; Region: PRK07940 1114966000785 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114966000786 Walker A motif; other site 1114966000787 ATP binding site [chemical binding]; other site 1114966000788 Walker B motif; other site 1114966000789 arginine finger; other site 1114966000790 Predicted membrane protein [Function unknown]; Region: COG2259 1114966000791 PSP1 C-terminal conserved region; Region: PSP1; cl00770 1114966000792 TAP-like protein; Region: Abhydrolase_4; pfam08386 1114966000793 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 1114966000794 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 1114966000795 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1114966000796 catalytic core [active] 1114966000797 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 1114966000798 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1114966000799 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1114966000800 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1114966000801 dimer interface [polypeptide binding]; other site 1114966000802 substrate binding site [chemical binding]; other site 1114966000803 metal binding sites [ion binding]; metal-binding site 1114966000804 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 1114966000805 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1114966000806 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 1114966000807 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1114966000808 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1114966000809 Ligand Binding Site [chemical binding]; other site 1114966000810 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1114966000811 active site 1114966000812 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1114966000813 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114966000814 Walker A motif; other site 1114966000815 ATP binding site [chemical binding]; other site 1114966000816 Walker B motif; other site 1114966000817 arginine finger; other site 1114966000818 Peptidase family M41; Region: Peptidase_M41; pfam01434 1114966000819 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1114966000820 homodecamer interface [polypeptide binding]; other site 1114966000821 GTP cyclohydrolase I; Provisional; Region: PLN03044 1114966000822 active site 1114966000823 putative catalytic site residues [active] 1114966000824 zinc binding site [ion binding]; other site 1114966000825 GTP-CH-I/GFRP interaction surface; other site 1114966000826 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1114966000827 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1114966000828 ligand binding site [chemical binding]; other site 1114966000829 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1114966000830 dihydropteroate synthase; Region: DHPS; TIGR01496 1114966000831 substrate binding pocket [chemical binding]; other site 1114966000832 dimer interface [polypeptide binding]; other site 1114966000833 inhibitor binding site; inhibition site 1114966000834 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1114966000835 homooctamer interface [polypeptide binding]; other site 1114966000836 active site 1114966000837 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1114966000838 catalytic center binding site [active] 1114966000839 ATP binding site [chemical binding]; other site 1114966000840 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1114966000841 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 1114966000842 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 1114966000843 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 1114966000844 Lsr2; Region: Lsr2; pfam11774 1114966000845 Clp protease ATP binding subunit; Region: clpC; CHL00095 1114966000846 Clp amino terminal domain; Region: Clp_N; pfam02861 1114966000847 Clp amino terminal domain; Region: Clp_N; pfam02861 1114966000848 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114966000849 Walker A motif; other site 1114966000850 ATP binding site [chemical binding]; other site 1114966000851 Walker B motif; other site 1114966000852 arginine finger; other site 1114966000853 UvrB/uvrC motif; Region: UVR; pfam02151 1114966000854 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114966000855 Walker A motif; other site 1114966000856 ATP binding site [chemical binding]; other site 1114966000857 Walker B motif; other site 1114966000858 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1114966000859 Protein of unknown function (DUF2891); Region: DUF2891; pfam11199 1114966000860 Predicted membrane protein [Function unknown]; Region: COG3817 1114966000861 Protein of unknown function (DUF979); Region: DUF979; pfam06166 1114966000862 Protein of unknown function (DUF969); Region: DUF969; pfam06149 1114966000863 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 1114966000864 putative active site [active] 1114966000865 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 1114966000866 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 1114966000867 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 1114966000868 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114966000869 putative substrate translocation pore; other site 1114966000870 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114966000871 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 1114966000872 TIGR01777 family protein; Region: yfcH 1114966000873 putative NAD(P) binding site [chemical binding]; other site 1114966000874 putative active site [active] 1114966000875 Rhomboid family; Region: Rhomboid; pfam01694 1114966000876 hypothetical protein; Provisional; Region: PRK06547 1114966000877 potential frameshift: common BLAST hit: gi|295129857|ref|YP_003580520.1| transcriptional regulator, LuxR family 1114966000878 Histidine kinase; Region: HisKA_3; pfam07730 1114966000879 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1114966000880 ATP binding site [chemical binding]; other site 1114966000881 Mg2+ binding site [ion binding]; other site 1114966000882 G-X-G motif; other site 1114966000883 CAT RNA binding domain; Region: CAT_RBD; smart01061 1114966000884 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1114966000885 PRD domain; Region: PRD; pfam00874 1114966000886 PRD domain; Region: PRD; pfam00874 1114966000887 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1114966000888 HPr interaction site; other site 1114966000889 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1114966000890 active site 1114966000891 phosphorylation site [posttranslational modification] 1114966000892 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 1114966000893 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1114966000894 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1114966000895 active site turn [active] 1114966000896 phosphorylation site [posttranslational modification] 1114966000897 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1114966000898 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1114966000899 endonuclease III; Region: ENDO3c; smart00478 1114966000900 minor groove reading motif; other site 1114966000901 helix-hairpin-helix signature motif; other site 1114966000902 active site 1114966000903 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1114966000904 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1114966000905 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1114966000906 inhibitor-cofactor binding pocket; inhibition site 1114966000907 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114966000908 catalytic residue [active] 1114966000909 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1114966000910 dimer interface [polypeptide binding]; other site 1114966000911 active site 1114966000912 Schiff base residues; other site 1114966000913 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 1114966000914 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1114966000915 active site 1114966000916 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1114966000917 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 1114966000918 domain interfaces; other site 1114966000919 active site 1114966000920 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1114966000921 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1114966000922 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1114966000923 substrate binding site [chemical binding]; other site 1114966000924 active site 1114966000925 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1114966000926 Glutamyl-tRNAGlu reductase, N-terminal domain; Region: GlutR_N; pfam05201 1114966000927 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1114966000928 ferrochelatase; Reviewed; Region: hemH; PRK00035 1114966000929 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1114966000930 C-terminal domain interface [polypeptide binding]; other site 1114966000931 active site 1114966000932 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1114966000933 active site 1114966000934 N-terminal domain interface [polypeptide binding]; other site 1114966000935 Chlorite dismutase; Region: Chlor_dismutase; pfam06778 1114966000936 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 1114966000937 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1114966000938 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 1114966000939 DNA repair protein RadA; Provisional; Region: PRK11823 1114966000940 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1114966000941 Walker A motif; other site 1114966000942 ATP binding site [chemical binding]; other site 1114966000943 Walker B motif; other site 1114966000944 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1114966000945 malate dehydrogenase; Provisional; Region: PRK13529 1114966000946 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1114966000947 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1114966000948 NAD(P) binding site [chemical binding]; other site 1114966000949 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 1114966000950 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1114966000951 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1114966000952 AP (apurinic/apyrimidinic) site pocket; other site 1114966000953 DNA interaction; other site 1114966000954 Metal-binding active site; metal-binding site 1114966000955 Proline dehydrogenase; Region: Pro_dh; cl03282 1114966000956 CAAX protease self-immunity; Region: Abi; pfam02517 1114966000957 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1114966000958 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1114966000959 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1114966000960 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1114966000961 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 1114966000962 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 1114966000963 active site 1114966000964 homodimer interface [polypeptide binding]; other site 1114966000965 SAM binding site [chemical binding]; other site 1114966000966 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1114966000967 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1114966000968 active site 1114966000969 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1114966000970 catalytic core [active] 1114966000971 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1114966000972 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1114966000973 catalytic residues [active] 1114966000974 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1114966000975 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1114966000976 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 1114966000977 ResB-like family; Region: ResB; pfam05140 1114966000978 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 1114966000979 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 1114966000980 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1114966000981 Sporulation and spore germination; Region: Germane; pfam10646 1114966000982 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1114966000983 classical (c) SDRs; Region: SDR_c; cd05233 1114966000984 NAD(P) binding site [chemical binding]; other site 1114966000985 active site 1114966000986 mycothione reductase; Reviewed; Region: PRK07846 1114966000987 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1114966000988 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1114966000989 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1114966000990 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1114966000991 intersubunit interface [polypeptide binding]; other site 1114966000992 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1114966000993 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1114966000994 Walker A/P-loop; other site 1114966000995 ATP binding site [chemical binding]; other site 1114966000996 Q-loop/lid; other site 1114966000997 ABC transporter signature motif; other site 1114966000998 Walker B; other site 1114966000999 D-loop; other site 1114966001000 H-loop/switch region; other site 1114966001001 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1114966001002 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1114966001003 ABC-ATPase subunit interface; other site 1114966001004 dimer interface [polypeptide binding]; other site 1114966001005 putative PBP binding regions; other site 1114966001006 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1114966001007 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1114966001008 FAD binding pocket [chemical binding]; other site 1114966001009 FAD binding motif [chemical binding]; other site 1114966001010 phosphate binding motif [ion binding]; other site 1114966001011 NAD binding pocket [chemical binding]; other site 1114966001012 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 1114966001013 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1114966001014 Walker A/P-loop; other site 1114966001015 ATP binding site [chemical binding]; other site 1114966001016 Q-loop/lid; other site 1114966001017 ABC transporter signature motif; other site 1114966001018 Walker B; other site 1114966001019 D-loop; other site 1114966001020 H-loop/switch region; other site 1114966001021 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1114966001022 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114966001023 dimer interface [polypeptide binding]; other site 1114966001024 conserved gate region; other site 1114966001025 putative PBP binding loops; other site 1114966001026 ABC-ATPase subunit interface; other site 1114966001027 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 1114966001028 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114966001029 dimer interface [polypeptide binding]; other site 1114966001030 conserved gate region; other site 1114966001031 putative PBP binding loops; other site 1114966001032 ABC-ATPase subunit interface; other site 1114966001033 PBP superfamily domain; Region: PBP_like_2; cl17296 1114966001034 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1114966001035 active site 1114966001036 Ap6A binding site [chemical binding]; other site 1114966001037 nudix motif; other site 1114966001038 metal binding site [ion binding]; metal-binding site 1114966001039 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1114966001040 catalytic core [active] 1114966001041 polyphosphate kinase; Provisional; Region: PRK05443 1114966001042 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1114966001043 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1114966001044 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 1114966001045 putative domain interface [polypeptide binding]; other site 1114966001046 putative active site [active] 1114966001047 catalytic site [active] 1114966001048 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 1114966001049 putative domain interface [polypeptide binding]; other site 1114966001050 putative active site [active] 1114966001051 catalytic site [active] 1114966001052 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1114966001053 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1114966001054 DNA binding site [nucleotide binding] 1114966001055 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1114966001056 putative active site [active] 1114966001057 dimerization interface [polypeptide binding]; other site 1114966001058 putative tRNAtyr binding site [nucleotide binding]; other site 1114966001059 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 1114966001060 heme-binding site [chemical binding]; other site 1114966001061 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 1114966001062 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1114966001063 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1114966001064 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1114966001065 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1114966001066 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1114966001067 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114966001068 NAD(P) binding site [chemical binding]; other site 1114966001069 active site 1114966001070 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1114966001071 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1114966001072 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1114966001073 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1114966001074 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1114966001075 dimerization domain swap beta strand [polypeptide binding]; other site 1114966001076 regulatory protein interface [polypeptide binding]; other site 1114966001077 active site 1114966001078 regulatory phosphorylation site [posttranslational modification]; other site 1114966001079 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1114966001080 substrate binding site; other site 1114966001081 dimer interface; other site 1114966001082 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1114966001083 homotrimer interaction site [polypeptide binding]; other site 1114966001084 zinc binding site [ion binding]; other site 1114966001085 CDP-binding sites; other site 1114966001086 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829 1114966001087 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 1114966001088 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 1114966001089 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1114966001090 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114966001091 active site 1114966001092 phosphorylation site [posttranslational modification] 1114966001093 intermolecular recognition site; other site 1114966001094 dimerization interface [polypeptide binding]; other site 1114966001095 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1114966001096 DNA binding site [nucleotide binding] 1114966001097 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1114966001098 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114966001099 dimer interface [polypeptide binding]; other site 1114966001100 phosphorylation site [posttranslational modification] 1114966001101 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114966001102 ATP binding site [chemical binding]; other site 1114966001103 Mg2+ binding site [ion binding]; other site 1114966001104 G-X-G motif; other site 1114966001105 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1114966001106 PhoU domain; Region: PhoU; pfam01895 1114966001107 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1114966001108 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 1114966001109 NodB motif; other site 1114966001110 active site 1114966001111 catalytic site [active] 1114966001112 Zn binding site [ion binding]; other site 1114966001113 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1114966001114 catalytic core [active] 1114966001115 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 1114966001116 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1114966001117 active site 1114966001118 phosphorylation site [posttranslational modification] 1114966001119 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 1114966001120 active site 1114966001121 P-loop; other site 1114966001122 phosphorylation site [posttranslational modification] 1114966001123 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 1114966001124 active site 1114966001125 homodimer interface [polypeptide binding]; other site 1114966001126 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1114966001127 serine hydroxymethyltransferase; Provisional; Region: PRK13580 1114966001128 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1114966001129 dimer interface [polypeptide binding]; other site 1114966001130 active site 1114966001131 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1114966001132 folate binding site [chemical binding]; other site 1114966001133 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1114966001134 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1114966001135 substrate binding site [chemical binding]; other site 1114966001136 ATP binding site [chemical binding]; other site 1114966001137 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 1114966001138 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1114966001139 active site 1114966001140 intersubunit interface [polypeptide binding]; other site 1114966001141 catalytic residue [active] 1114966001142 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1114966001143 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1114966001144 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 1114966001145 substrate binding site [chemical binding]; other site 1114966001146 catalytic residues [active] 1114966001147 Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; cl01752 1114966001148 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1114966001149 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1114966001150 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1114966001151 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1114966001152 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1114966001153 active site 1114966001154 HIGH motif; other site 1114966001155 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1114966001156 KMSKS motif; other site 1114966001157 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1114966001158 tRNA binding surface [nucleotide binding]; other site 1114966001159 anticodon binding site; other site 1114966001160 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 1114966001161 Asp23 family; Region: Asp23; pfam03780 1114966001162 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 1114966001163 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1114966001164 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1114966001165 DNA binding residues [nucleotide binding] 1114966001166 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1114966001167 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1114966001168 Walker A/P-loop; other site 1114966001169 ATP binding site [chemical binding]; other site 1114966001170 Q-loop/lid; other site 1114966001171 ABC transporter signature motif; other site 1114966001172 Walker B; other site 1114966001173 D-loop; other site 1114966001174 H-loop/switch region; other site 1114966001175 TOBE domain; Region: TOBE_2; pfam08402 1114966001176 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1114966001177 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1114966001178 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1114966001179 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1114966001180 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1114966001181 putative DNA binding site [nucleotide binding]; other site 1114966001182 putative Zn2+ binding site [ion binding]; other site 1114966001183 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1114966001184 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1114966001185 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1114966001186 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1114966001187 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1114966001188 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1114966001189 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1114966001190 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114966001191 dimer interface [polypeptide binding]; other site 1114966001192 conserved gate region; other site 1114966001193 putative PBP binding loops; other site 1114966001194 ABC-ATPase subunit interface; other site 1114966001195 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1114966001196 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114966001197 dimer interface [polypeptide binding]; other site 1114966001198 conserved gate region; other site 1114966001199 ABC-ATPase subunit interface; other site 1114966001200 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 1114966001201 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1114966001202 NAD(P) binding site [chemical binding]; other site 1114966001203 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1114966001204 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1114966001205 substrate-cofactor binding pocket; other site 1114966001206 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114966001207 catalytic residue [active] 1114966001208 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1114966001209 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 1114966001210 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1114966001211 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1114966001212 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114966001213 Walker A/P-loop; other site 1114966001214 ATP binding site [chemical binding]; other site 1114966001215 Q-loop/lid; other site 1114966001216 ABC transporter signature motif; other site 1114966001217 Walker B; other site 1114966001218 D-loop; other site 1114966001219 H-loop/switch region; other site 1114966001220 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1114966001221 Protein of unknown function, DUF488; Region: DUF488; cl01246 1114966001222 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 1114966001223 putative ADP-ribose binding site [chemical binding]; other site 1114966001224 putative active site [active] 1114966001225 potential frameshift: common BLAST hit: gi|295129966|ref|YP_003580629.1| oxidoreductase, zinc-binding dehydrogenase family protein 1114966001226 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1114966001227 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1114966001228 Walker A/P-loop; other site 1114966001229 ATP binding site [chemical binding]; other site 1114966001230 Q-loop/lid; other site 1114966001231 ABC transporter signature motif; other site 1114966001232 Walker B; other site 1114966001233 D-loop; other site 1114966001234 H-loop/switch region; other site 1114966001235 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1114966001236 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1114966001237 Histidine kinase; Region: HisKA_3; pfam07730 1114966001238 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1114966001239 ATP binding site [chemical binding]; other site 1114966001240 Mg2+ binding site [ion binding]; other site 1114966001241 G-X-G motif; other site 1114966001242 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1114966001243 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114966001244 active site 1114966001245 phosphorylation site [posttranslational modification] 1114966001246 intermolecular recognition site; other site 1114966001247 dimerization interface [polypeptide binding]; other site 1114966001248 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1114966001249 DNA binding residues [nucleotide binding] 1114966001250 dimerization interface [polypeptide binding]; other site 1114966001251 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1114966001252 catalytic core [active] 1114966001253 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 1114966001254 cobyric acid synthase; Provisional; Region: PRK00784 1114966001255 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1114966001256 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1114966001257 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1114966001258 catalytic triad [active] 1114966001259 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 1114966001260 active site 1114966001261 SAM binding site [chemical binding]; other site 1114966001262 homodimer interface [polypeptide binding]; other site 1114966001263 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 1114966001264 active site 1114966001265 SAM binding site [chemical binding]; other site 1114966001266 homodimer interface [polypeptide binding]; other site 1114966001267 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 1114966001268 putative homodimer interface [polypeptide binding]; other site 1114966001269 active site 1114966001270 SAM binding site [chemical binding]; other site 1114966001271 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 1114966001272 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 1114966001273 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 1114966001274 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 1114966001275 active site 1114966001276 SAM binding site [chemical binding]; other site 1114966001277 homodimer interface [polypeptide binding]; other site 1114966001278 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1114966001279 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1114966001280 putative active site [active] 1114966001281 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 1114966001282 putative active site [active] 1114966001283 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 1114966001284 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1114966001285 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1114966001286 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1114966001287 putative PBP binding regions; other site 1114966001288 ABC-ATPase subunit interface; other site 1114966001289 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1114966001290 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1114966001291 Walker A/P-loop; other site 1114966001292 ATP binding site [chemical binding]; other site 1114966001293 Q-loop/lid; other site 1114966001294 ABC transporter signature motif; other site 1114966001295 Walker B; other site 1114966001296 D-loop; other site 1114966001297 H-loop/switch region; other site 1114966001298 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1114966001299 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 1114966001300 intersubunit interface [polypeptide binding]; other site 1114966001301 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 1114966001302 AAA domain; Region: AAA_14; pfam13173 1114966001303 Nuclease-related domain; Region: NERD; pfam08378 1114966001304 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 1114966001305 Precorrin-8X methylmutase; Region: CbiC; pfam02570 1114966001306 cobalt transport protein CbiM; Validated; Region: PRK08319 1114966001307 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 1114966001308 cobalt transport protein CbiN; Provisional; Region: PRK02898 1114966001309 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 1114966001310 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1114966001311 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 1114966001312 Walker A/P-loop; other site 1114966001313 ATP binding site [chemical binding]; other site 1114966001314 Q-loop/lid; other site 1114966001315 ABC transporter signature motif; other site 1114966001316 Walker B; other site 1114966001317 D-loop; other site 1114966001318 H-loop/switch region; other site 1114966001319 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 1114966001320 Methyltransferase domain; Region: Methyltransf_18; pfam12847 1114966001321 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 1114966001322 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 1114966001323 homodimer interface [polypeptide binding]; other site 1114966001324 Walker A motif; other site 1114966001325 ATP binding site [chemical binding]; other site 1114966001326 hydroxycobalamin binding site [chemical binding]; other site 1114966001327 Walker B motif; other site 1114966001328 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 1114966001329 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 1114966001330 catalytic triad [active] 1114966001331 hypothetical protein; Provisional; Region: PRK07908 1114966001332 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1114966001333 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114966001334 homodimer interface [polypeptide binding]; other site 1114966001335 catalytic residue [active] 1114966001336 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1114966001337 homodimer interface [polypeptide binding]; other site 1114966001338 active site 1114966001339 SAM binding site [chemical binding]; other site 1114966001340 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 1114966001341 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 1114966001342 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 1114966001343 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1114966001344 putative dimer interface [polypeptide binding]; other site 1114966001345 active site pocket [active] 1114966001346 putative cataytic base [active] 1114966001347 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 1114966001348 homotrimer interface [polypeptide binding]; other site 1114966001349 Walker A motif; other site 1114966001350 GTP binding site [chemical binding]; other site 1114966001351 Walker B motif; other site 1114966001352 cobalamin synthase; Reviewed; Region: cobS; PRK00235 1114966001353 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1114966001354 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1114966001355 intersubunit interface [polypeptide binding]; other site 1114966001356 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 1114966001357 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1114966001358 active site 1114966001359 phosphorylation site [posttranslational modification] 1114966001360 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 1114966001361 active site 1114966001362 P-loop; other site 1114966001363 phosphorylation site [posttranslational modification] 1114966001364 S-Ribosylhomocysteinase (LuxS); Region: LuxS; cl00802 1114966001365 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1114966001366 S-ribosylhomocysteinase; Provisional; Region: PRK02260 1114966001367 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 1114966001368 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1114966001369 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1114966001370 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 1114966001371 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1114966001372 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1114966001373 ring oligomerisation interface [polypeptide binding]; other site 1114966001374 ATP/Mg binding site [chemical binding]; other site 1114966001375 stacking interactions; other site 1114966001376 hinge regions; other site 1114966001377 Transaldolase; Region: Transaldolase; pfam00923 1114966001378 catalytic residue [active] 1114966001379 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1114966001380 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114966001381 DNA-binding site [nucleotide binding]; DNA binding site 1114966001382 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1114966001383 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1114966001384 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1114966001385 substrate binding site [chemical binding]; other site 1114966001386 ATP binding site [chemical binding]; other site 1114966001387 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 1114966001388 KduI/IolB family; Region: KduI; pfam04962 1114966001389 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 1114966001390 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1114966001391 PYR/PP interface [polypeptide binding]; other site 1114966001392 dimer interface [polypeptide binding]; other site 1114966001393 TPP binding site [chemical binding]; other site 1114966001394 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cd00368 1114966001395 molybdopterin cofactor binding site; other site 1114966001396 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 1114966001397 TPP-binding site; other site 1114966001398 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1114966001399 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1114966001400 tetrameric interface [polypeptide binding]; other site 1114966001401 NAD binding site [chemical binding]; other site 1114966001402 catalytic residues [active] 1114966001403 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1114966001404 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1114966001405 DNA binding site [nucleotide binding] 1114966001406 domain linker motif; other site 1114966001407 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1114966001408 dimerization interface [polypeptide binding]; other site 1114966001409 ligand binding site [chemical binding]; other site 1114966001410 potential frameshift: common BLAST hit: gi|295130020|ref|YP_003580683.1| oxidoreductase, NAD-binding domain protein 1114966001411 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1114966001412 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1114966001413 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1114966001414 AP (apurinic/apyrimidinic) site pocket; other site 1114966001415 DNA interaction; other site 1114966001416 Metal-binding active site; metal-binding site 1114966001417 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1114966001418 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1114966001419 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1114966001420 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 1114966001421 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114966001422 putative substrate translocation pore; other site 1114966001423 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114966001424 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1114966001425 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1114966001426 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1114966001427 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1114966001428 DNA interaction; other site 1114966001429 Metal-binding active site; metal-binding site 1114966001430 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1114966001431 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1114966001432 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1114966001433 CAAX protease self-immunity; Region: Abi; pfam02517 1114966001434 CutC family; Region: CutC; cl01218 1114966001435 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1114966001436 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1114966001437 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1114966001438 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1114966001439 ATP binding site [chemical binding]; other site 1114966001440 putative Mg++ binding site [ion binding]; other site 1114966001441 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1114966001442 nucleotide binding region [chemical binding]; other site 1114966001443 ATP-binding site [chemical binding]; other site 1114966001444 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1114966001445 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1114966001446 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1114966001447 active site 1114966001448 trimer interface [polypeptide binding]; other site 1114966001449 allosteric site; other site 1114966001450 active site lid [active] 1114966001451 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1114966001452 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1114966001453 DNA-binding site [nucleotide binding]; DNA binding site 1114966001454 RNA-binding motif; other site 1114966001455 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 1114966001456 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1114966001457 phosphoserine aminotransferase; Provisional; Region: PRK03080 1114966001458 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1114966001459 catalytic residue [active] 1114966001460 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1114966001461 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1114966001462 active site 1114966001463 dimer interface [polypeptide binding]; other site 1114966001464 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1114966001465 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 1114966001466 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1114966001467 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1114966001468 catalytic residues [active] 1114966001469 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1114966001470 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114966001471 putative substrate translocation pore; other site 1114966001472 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114966001473 Eukaryotic UGPase catalyses the synthesis of UDP-Glucose; Region: UGPase_euk; cd00897 1114966001474 active site 1114966001475 substrate binding site; other site 1114966001476 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 1114966001477 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1114966001478 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1114966001479 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 1114966001480 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1114966001481 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 1114966001482 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1114966001483 dimer interface [polypeptide binding]; other site 1114966001484 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1114966001485 putative MPT binding site; other site 1114966001486 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1114966001487 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1114966001488 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 1114966001489 MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor...; Region: MoaC; cl00242 1114966001490 trimer interface [polypeptide binding]; other site 1114966001491 dimer interface [polypeptide binding]; other site 1114966001492 putative active site [active] 1114966001493 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1114966001494 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1114966001495 dimer interface [polypeptide binding]; other site 1114966001496 putative functional site; other site 1114966001497 putative MPT binding site; other site 1114966001498 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1114966001499 MoaE homodimer interface [polypeptide binding]; other site 1114966001500 MoaD interaction [polypeptide binding]; other site 1114966001501 active site residues [active] 1114966001502 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1114966001503 MoaE interaction surface [polypeptide binding]; other site 1114966001504 MoeB interaction surface [polypeptide binding]; other site 1114966001505 thiocarboxylated glycine; other site 1114966001506 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1114966001507 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1114966001508 FeS/SAM binding site; other site 1114966001509 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1114966001510 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 1114966001511 DNA binding residues [nucleotide binding] 1114966001512 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 1114966001513 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 1114966001514 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1114966001515 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1114966001516 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114966001517 dimer interface [polypeptide binding]; other site 1114966001518 conserved gate region; other site 1114966001519 putative PBP binding loops; other site 1114966001520 ABC-ATPase subunit interface; other site 1114966001521 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 1114966001522 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114966001523 Walker A/P-loop; other site 1114966001524 ATP binding site [chemical binding]; other site 1114966001525 Q-loop/lid; other site 1114966001526 ABC transporter signature motif; other site 1114966001527 Walker B; other site 1114966001528 D-loop; other site 1114966001529 H-loop/switch region; other site 1114966001530 Predicted transcriptional regulator [Transcription]; Region: COG2345 1114966001531 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 1114966001532 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 1114966001533 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 1114966001534 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1114966001535 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 1114966001536 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1114966001537 [4Fe-4S] binding site [ion binding]; other site 1114966001538 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1114966001539 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1114966001540 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1114966001541 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1114966001542 molybdopterin cofactor binding site; other site 1114966001543 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1114966001544 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114966001545 putative substrate translocation pore; other site 1114966001546 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1114966001547 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1114966001548 GTP binding site; other site 1114966001549 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1114966001550 MPT binding site; other site 1114966001551 trimer interface [polypeptide binding]; other site 1114966001552 DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519 1114966001553 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 1114966001554 4Fe-4S binding domain; Region: Fer4; pfam00037 1114966001555 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 1114966001556 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 1114966001557 putative [Fe4-S4] binding site [ion binding]; other site 1114966001558 putative molybdopterin cofactor binding site [chemical binding]; other site 1114966001559 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 1114966001560 putative molybdopterin cofactor binding site; other site 1114966001561 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 1114966001562 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1114966001563 ATP binding site [chemical binding]; other site 1114966001564 substrate interface [chemical binding]; other site 1114966001565 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1114966001566 ThiS interaction site; other site 1114966001567 putative active site [active] 1114966001568 tetramer interface [polypeptide binding]; other site 1114966001569 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1114966001570 thiS-thiF/thiG interaction site; other site 1114966001571 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1114966001572 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1114966001573 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 1114966001574 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 1114966001575 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 1114966001576 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1114966001577 Predicted methyltransferases [General function prediction only]; Region: COG0313 1114966001578 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1114966001579 putative SAM binding site [chemical binding]; other site 1114966001580 putative homodimer interface [polypeptide binding]; other site 1114966001581 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1114966001582 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1114966001583 active site 1114966001584 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1114966001585 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 1114966001586 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 1114966001587 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1114966001588 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1114966001589 MarR family; Region: MarR_2; cl17246 1114966001590 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114966001591 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1114966001592 DNA-binding interface [nucleotide binding]; DNA binding site 1114966001593 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14360 1114966001594 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1114966001595 Substrate binding site; other site 1114966001596 Mg++ binding site; other site 1114966001597 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1114966001598 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1114966001599 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 1114966001600 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1114966001601 active site 1114966001602 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1114966001603 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1114966001604 5S rRNA interface [nucleotide binding]; other site 1114966001605 CTC domain interface [polypeptide binding]; other site 1114966001606 L16 interface [polypeptide binding]; other site 1114966001607 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1114966001608 putative active site [active] 1114966001609 catalytic residue [active] 1114966001610 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1114966001611 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1114966001612 NAD binding site [chemical binding]; other site 1114966001613 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1114966001614 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH6; cd08260 1114966001615 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1114966001616 putative NAD(P) binding site [chemical binding]; other site 1114966001617 catalytic Zn binding site [ion binding]; other site 1114966001618 structural Zn binding site [ion binding]; other site 1114966001619 Protease prsW family; Region: PrsW-protease; pfam13367 1114966001620 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1114966001621 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1114966001622 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1114966001623 ATP binding site [chemical binding]; other site 1114966001624 putative Mg++ binding site [ion binding]; other site 1114966001625 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1114966001626 nucleotide binding region [chemical binding]; other site 1114966001627 ATP-binding site [chemical binding]; other site 1114966001628 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1114966001629 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1114966001630 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12333 1114966001631 homodimer interface [polypeptide binding]; other site 1114966001632 metal binding site [ion binding]; metal-binding site 1114966001633 enolase; Provisional; Region: eno; PRK00077 1114966001634 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1114966001635 dimer interface [polypeptide binding]; other site 1114966001636 metal binding site [ion binding]; metal-binding site 1114966001637 substrate binding pocket [chemical binding]; other site 1114966001638 Septum formation initiator; Region: DivIC; pfam04977 1114966001639 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1114966001640 Protein of unknown function (DUF501); Region: DUF501; pfam04417 1114966001641 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1114966001642 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1114966001643 Bax inhibitor 1 like; Region: BaxI_1; cl17691 1114966001644 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 1114966001645 nudix motif; other site 1114966001646 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114966001647 Coenzyme A binding pocket [chemical binding]; other site 1114966001648 Predicted membrane protein [Function unknown]; Region: COG2246 1114966001649 GtrA-like protein; Region: GtrA; pfam04138 1114966001650 Predicted membrane protein [Function unknown]; Region: COG1297 1114966001651 putative oligopeptide transporter, OPT family; Region: TIGR00733 1114966001652 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1114966001653 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1114966001654 active site 1114966001655 catalytic tetrad [active] 1114966001656 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 1114966001657 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 1114966001658 Na2 binding site [ion binding]; other site 1114966001659 putative substrate binding site 1 [chemical binding]; other site 1114966001660 Na binding site 1 [ion binding]; other site 1114966001661 putative substrate binding site 2 [chemical binding]; other site 1114966001662 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1114966001663 ligand binding site [chemical binding]; other site 1114966001664 active site 1114966001665 UGI interface [polypeptide binding]; other site 1114966001666 catalytic site [active] 1114966001667 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1114966001668 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1114966001669 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1114966001670 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1114966001671 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1114966001672 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 1114966001673 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 1114966001674 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 1114966001675 catalytic residues [active] 1114966001676 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 1114966001677 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 1114966001678 catalytic residue [active] 1114966001679 putative FPP diphosphate binding site; other site 1114966001680 putative FPP binding hydrophobic cleft; other site 1114966001681 dimer interface [polypeptide binding]; other site 1114966001682 putative IPP diphosphate binding site; other site 1114966001683 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1114966001684 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1114966001685 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 1114966001686 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 1114966001687 putative active site [active] 1114966001688 PhoH-like protein; Region: PhoH; pfam02562 1114966001689 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 1114966001690 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1114966001691 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1114966001692 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1114966001693 generic binding surface II; other site 1114966001694 generic binding surface I; other site 1114966001695 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 1114966001696 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1114966001697 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1114966001698 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1114966001699 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1114966001700 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1114966001701 RmuC family; Region: RmuC; pfam02646 1114966001702 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 1114966001703 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 1114966001704 active site 1114966001705 metal binding site [ion binding]; metal-binding site 1114966001706 GTP-binding protein YchF; Reviewed; Region: PRK09601 1114966001707 YchF GTPase; Region: YchF; cd01900 1114966001708 G1 box; other site 1114966001709 GTP/Mg2+ binding site [chemical binding]; other site 1114966001710 Switch I region; other site 1114966001711 G2 box; other site 1114966001712 Switch II region; other site 1114966001713 G3 box; other site 1114966001714 G4 box; other site 1114966001715 G5 box; other site 1114966001716 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1114966001717 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114966001718 putative substrate translocation pore; other site 1114966001719 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114966001720 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1114966001721 MarR family; Region: MarR; pfam01047 1114966001722 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1114966001723 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 1114966001724 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1114966001725 potential catalytic triad [active] 1114966001726 conserved cys residue [active] 1114966001727 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 1114966001728 Spore germination protein; Region: Spore_permease; cl17796 1114966001729 arginine deiminase; Provisional; Region: PRK01388 1114966001730 ornithine carbamoyltransferase; Validated; Region: PRK02102 1114966001731 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1114966001732 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1114966001733 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 1114966001734 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1114966001735 putative substrate binding site [chemical binding]; other site 1114966001736 nucleotide binding site [chemical binding]; other site 1114966001737 nucleotide binding site [chemical binding]; other site 1114966001738 homodimer interface [polypeptide binding]; other site 1114966001739 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1114966001740 Peptidyl-tRNA hydrolase, type 2 (PTH2)_like . Peptidyl-tRNA hydrolase activity releases tRNA from the premature translation termination product peptidyl-tRNA. Two structurally different enzymes have been reported to encode such activity, Pth present in...; Region: PTH2_family; cl00869 1114966001741 dimer interface [polypeptide binding]; other site 1114966001742 putative active site [active] 1114966001743 ACT domain; Region: ACT_6; pfam13740 1114966001744 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 1114966001745 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869 1114966001746 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1114966001747 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1114966001748 active site 1114966001749 catalytic tetrad [active] 1114966001750 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1114966001751 dimer interface [polypeptide binding]; other site 1114966001752 catalytic triad [active] 1114966001753 peroxidatic and resolving cysteines [active] 1114966001754 lysine transporter; Provisional; Region: PRK10836 1114966001755 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like; cd11354 1114966001756 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1114966001757 active site 1114966001758 catalytic site [active] 1114966001759 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 1114966001760 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1114966001761 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1114966001762 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1114966001763 potential frameshift: common BLAST hit: gi|50842080|ref|YP_055307.1| lysophospholipase 1114966001764 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 1114966001765 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 1114966001766 heterodimer interface [polypeptide binding]; other site 1114966001767 substrate interaction site [chemical binding]; other site 1114966001768 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 1114966001769 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 1114966001770 active site 1114966001771 substrate binding site [chemical binding]; other site 1114966001772 coenzyme B12 binding site [chemical binding]; other site 1114966001773 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 1114966001774 B12 binding site [chemical binding]; other site 1114966001775 cobalt ligand [ion binding]; other site 1114966001776 membrane ATPase/protein kinase; Provisional; Region: PRK09435 1114966001777 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 1114966001778 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 1114966001779 Walker A; other site 1114966001780 G1 box; other site 1114966001781 GTP/Mg2+ binding site [chemical binding]; other site 1114966001782 Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496 1114966001783 active site 1114966001784 catalytic triad [active] 1114966001785 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1114966001786 RNA binding surface [nucleotide binding]; other site 1114966001787 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1114966001788 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1114966001789 Walker A/P-loop; other site 1114966001790 ATP binding site [chemical binding]; other site 1114966001791 Q-loop/lid; other site 1114966001792 ABC transporter signature motif; other site 1114966001793 Walker B; other site 1114966001794 D-loop; other site 1114966001795 H-loop/switch region; other site 1114966001796 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114966001797 dimer interface [polypeptide binding]; other site 1114966001798 ABC-ATPase subunit interface; other site 1114966001799 putative PBP binding loops; other site 1114966001800 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1114966001801 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1114966001802 DNA binding site [nucleotide binding] 1114966001803 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 1114966001804 ligand binding site [chemical binding]; other site 1114966001805 dimerization interface (open form) [polypeptide binding]; other site 1114966001806 dimerization interface (closed form) [polypeptide binding]; other site 1114966001807 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1114966001808 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1114966001809 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 1114966001810 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 1114966001811 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1114966001812 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114966001813 dimer interface [polypeptide binding]; other site 1114966001814 conserved gate region; other site 1114966001815 putative PBP binding loops; other site 1114966001816 ABC-ATPase subunit interface; other site 1114966001817 Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812 1114966001818 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 1114966001819 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 1114966001820 trimer interface [polypeptide binding]; other site 1114966001821 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1114966001822 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 1114966001823 substrate binding site [chemical binding]; other site 1114966001824 Mn binding site [ion binding]; other site 1114966001825 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 1114966001826 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1114966001827 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1114966001828 Walker A/P-loop; other site 1114966001829 ATP binding site [chemical binding]; other site 1114966001830 Q-loop/lid; other site 1114966001831 ABC transporter signature motif; other site 1114966001832 Walker B; other site 1114966001833 D-loop; other site 1114966001834 H-loop/switch region; other site 1114966001835 FtsX-like permease family; Region: FtsX; pfam02687 1114966001836 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1114966001837 dimer interface [polypeptide binding]; other site 1114966001838 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1114966001839 putative PBP binding regions; other site 1114966001840 ABC-ATPase subunit interface; other site 1114966001841 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1114966001842 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1114966001843 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1114966001844 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1114966001845 intersubunit interface [polypeptide binding]; other site 1114966001846 Isochorismatase family; Region: Isochorismatase; pfam00857 1114966001847 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1114966001848 catalytic triad [active] 1114966001849 conserved cis-peptide bond; other site 1114966001850 potential frameshift: common BLAST hit: gi|295130193|ref|YP_003580856.1| permease, cytosine/purine, uracil, thiamine, allantoin family 1114966001851 Proline dehydrogenase; Region: Pro_dh; cl03282 1114966001852 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 1114966001853 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1114966001854 Glutamate binding site [chemical binding]; other site 1114966001855 NAD binding site [chemical binding]; other site 1114966001856 catalytic residues [active] 1114966001857 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1114966001858 L-iditol 2-dehydrogenase; Region: iditol_2_DH_like; cd08235 1114966001859 putative NAD(P) binding site [chemical binding]; other site 1114966001860 catalytic Zn binding site [ion binding]; other site 1114966001861 dihydroxyacetone kinase; Provisional; Region: PRK14479 1114966001862 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 1114966001863 DAK2 domain; Region: Dak2; pfam02734 1114966001864 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 1114966001865 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1114966001866 active site 1114966001867 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1114966001868 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114966001869 Coenzyme A binding pocket [chemical binding]; other site 1114966001870 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1114966001871 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 1114966001872 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 1114966001873 ligand binding site [chemical binding]; other site 1114966001874 homodimer interface [polypeptide binding]; other site 1114966001875 NAD(P) binding site [chemical binding]; other site 1114966001876 trimer interface B [polypeptide binding]; other site 1114966001877 trimer interface A [polypeptide binding]; other site 1114966001878 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 1114966001879 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 1114966001880 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 1114966001881 Ferredoxin [Energy production and conversion]; Region: COG1146 1114966001882 4Fe-4S binding domain; Region: Fer4; pfam00037 1114966001883 succinyldiaminopimelate transaminase; Region: DapC_actino; TIGR03539 1114966001884 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1114966001885 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114966001886 homodimer interface [polypeptide binding]; other site 1114966001887 catalytic residue [active] 1114966001888 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 1114966001889 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 1114966001890 putative trimer interface [polypeptide binding]; other site 1114966001891 putative CoA binding site [chemical binding]; other site 1114966001892 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 1114966001893 Amidinotransferase; Region: Amidinotransf; cl12043 1114966001894 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1114966001895 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114966001896 metabolite-proton symporter; Region: 2A0106; TIGR00883 1114966001897 putative substrate translocation pore; other site 1114966001898 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 1114966001899 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 1114966001900 metal binding site [ion binding]; metal-binding site 1114966001901 putative dimer interface [polypeptide binding]; other site 1114966001902 DivIVA domain; Region: DivI1A_domain; TIGR03544 1114966001903 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 1114966001904 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 1114966001905 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1114966001906 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 1114966001907 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1114966001908 ligand binding site; other site 1114966001909 oligomer interface; other site 1114966001910 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1114966001911 dimer interface [polypeptide binding]; other site 1114966001912 N-terminal domain interface [polypeptide binding]; other site 1114966001913 sulfate 1 binding site; other site 1114966001914 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1114966001915 S-adenosylmethionine binding site [chemical binding]; other site 1114966001916 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1114966001917 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1114966001918 dimer interface [polypeptide binding]; other site 1114966001919 active site 1114966001920 catalytic residue [active] 1114966001921 sec-independent translocase; Provisional; Region: PRK01371 1114966001922 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 1114966001923 Domain of unknown function DUF59; Region: DUF59; pfam01883 1114966001924 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1114966001925 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1114966001926 Walker A motif; other site 1114966001927 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 1114966001928 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1114966001929 MgtE intracellular N domain; Region: MgtE_N; smart00924 1114966001930 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1114966001931 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1114966001932 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 1114966001933 proline aminopeptidase P II; Provisional; Region: PRK10879 1114966001934 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1114966001935 active site 1114966001936 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 1114966001937 Putative zinc ribbon domain; Region: DUF164; pfam02591 1114966001938 YcfA-like protein; Region: YcfA; cl00752 1114966001939 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 1114966001940 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1114966001941 intersubunit interface [polypeptide binding]; other site 1114966001942 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1114966001943 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1114966001944 ABC-ATPase subunit interface; other site 1114966001945 dimer interface [polypeptide binding]; other site 1114966001946 putative PBP binding regions; other site 1114966001947 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1114966001948 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1114966001949 Walker A/P-loop; other site 1114966001950 ATP binding site [chemical binding]; other site 1114966001951 Q-loop/lid; other site 1114966001952 ABC transporter signature motif; other site 1114966001953 Walker B; other site 1114966001954 D-loop; other site 1114966001955 H-loop/switch region; other site 1114966001956 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 1114966001957 dimer interface [polypeptide binding]; other site 1114966001958 [2Fe-2S] cluster binding site [ion binding]; other site 1114966001959 Protein of unknown function (DUF466); Region: DUF466; cl01082 1114966001960 potential frameshift: common BLAST hit: gi|50842147|ref|YP_055374.1| carbon starvation protein A 1114966001961 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 1114966001962 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1114966001963 active site 1114966001964 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 1114966001965 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1114966001966 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1114966001967 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1114966001968 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 1114966001969 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1114966001970 metal binding triad; other site 1114966001971 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1114966001972 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1114966001973 metal binding triad; other site 1114966001974 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1114966001975 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1114966001976 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 1114966001977 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1114966001978 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1114966001979 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1114966001980 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1114966001981 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1114966001982 putative active site [active] 1114966001983 glutamine synthetase, type I; Region: GlnA; TIGR00653 1114966001984 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1114966001985 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1114966001986 RDD family; Region: RDD; pfam06271 1114966001987 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1114966001988 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 1114966001989 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1114966001990 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1114966001991 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1114966001992 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 1114966001993 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1114966001994 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114966001995 DNA-binding site [nucleotide binding]; DNA binding site 1114966001996 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1114966001997 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1114966001998 active site turn [active] 1114966001999 phosphorylation site [posttranslational modification] 1114966002000 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1114966002001 active site turn [active] 1114966002002 phosphorylation site [posttranslational modification] 1114966002003 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1114966002004 HPr interaction site; other site 1114966002005 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1114966002006 active site 1114966002007 phosphorylation site [posttranslational modification] 1114966002008 Protein of unknown function (DUF1440); Region: DUF1440; pfam07274 1114966002009 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 1114966002010 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1114966002011 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1114966002012 ABC transporter; Region: ABC_tran_2; pfam12848 1114966002013 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1114966002014 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 1114966002015 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 1114966002016 potential frameshift: common BLAST hit: gi|295130260|ref|YP_003580923.1| BNR/Asp-box repeat protein 1114966002017 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1114966002018 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 1114966002019 Asp-box motif; other site 1114966002020 catalytic site [active] 1114966002021 putative sialic acid transporter; Provisional; Region: PRK03893 1114966002022 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114966002023 putative substrate translocation pore; other site 1114966002024 CAMP factor (Cfa); Region: CAMP_factor; pfam07373 1114966002025 lipoyl synthase; Provisional; Region: PRK05481 1114966002026 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1114966002027 FeS/SAM binding site; other site 1114966002028 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1114966002029 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1114966002030 metal-binding site [ion binding] 1114966002031 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1114966002032 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114966002033 motif II; other site 1114966002034 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 1114966002035 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1114966002036 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase; Region: SucB_Actino; TIGR02927 1114966002037 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1114966002038 E3 interaction surface; other site 1114966002039 lipoyl attachment site [posttranslational modification]; other site 1114966002040 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1114966002041 E3 interaction surface; other site 1114966002042 lipoyl attachment site [posttranslational modification]; other site 1114966002043 e3 binding domain; Region: E3_binding; pfam02817 1114966002044 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1114966002045 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1114966002046 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1114966002047 interface (dimer of trimers) [polypeptide binding]; other site 1114966002048 Substrate-binding/catalytic site; other site 1114966002049 Zn-binding sites [ion binding]; other site 1114966002050 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 1114966002051 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1114966002052 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 1114966002053 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 1114966002054 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1114966002055 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1114966002056 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1114966002057 D-pathway; other site 1114966002058 Putative ubiquinol binding site [chemical binding]; other site 1114966002059 Low-spin heme (heme b) binding site [chemical binding]; other site 1114966002060 Putative water exit pathway; other site 1114966002061 Binuclear center (heme o3/CuB) [ion binding]; other site 1114966002062 K-pathway; other site 1114966002063 Putative proton exit pathway; other site 1114966002064 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 1114966002065 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1114966002066 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1114966002067 Walker A/P-loop; other site 1114966002068 ATP binding site [chemical binding]; other site 1114966002069 Q-loop/lid; other site 1114966002070 ABC transporter signature motif; other site 1114966002071 Walker B; other site 1114966002072 D-loop; other site 1114966002073 H-loop/switch region; other site 1114966002074 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114966002075 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1114966002076 NAD(P) binding site [chemical binding]; other site 1114966002077 active site 1114966002078 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 1114966002079 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1114966002080 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1114966002081 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1114966002082 phosphate binding site [ion binding]; other site 1114966002083 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1114966002084 active site 1114966002085 DNA binding site [nucleotide binding] 1114966002086 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1114966002087 heme bH binding site [chemical binding]; other site 1114966002088 intrachain domain interface; other site 1114966002089 heme bL binding site [chemical binding]; other site 1114966002090 interchain domain interface [polypeptide binding]; other site 1114966002091 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 1114966002092 Qo binding site; other site 1114966002093 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1114966002094 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1114966002095 iron-sulfur cluster [ion binding]; other site 1114966002096 [2Fe-2S] cluster binding site [ion binding]; other site 1114966002097 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1114966002098 Cytochrome c; Region: Cytochrom_C; pfam00034 1114966002099 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1114966002100 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1114966002101 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 1114966002102 Subunit I/III interface [polypeptide binding]; other site 1114966002103 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1114966002104 active site 1114966002105 phosphorylation site [posttranslational modification] 1114966002106 intermolecular recognition site; other site 1114966002107 dimerization interface [polypeptide binding]; other site 1114966002108 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1114966002109 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304 1114966002110 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 1114966002111 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1114966002112 active site 1114966002113 Rhomboid family; Region: Rhomboid; cl11446 1114966002114 hypothetical protein; Validated; Region: PRK07883 1114966002115 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1114966002116 active site 1114966002117 catalytic site [active] 1114966002118 substrate binding site [chemical binding]; other site 1114966002119 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1114966002120 GIY-YIG motif/motif A; other site 1114966002121 active site 1114966002122 catalytic site [active] 1114966002123 putative DNA binding site [nucleotide binding]; other site 1114966002124 metal binding site [ion binding]; metal-binding site 1114966002125 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1114966002126 NlpC/P60 family; Region: NLPC_P60; pfam00877 1114966002127 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 1114966002128 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1114966002129 nucleotide binding site [chemical binding]; other site 1114966002130 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1114966002131 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1114966002132 putative acyl-acceptor binding pocket; other site 1114966002133 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 1114966002134 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 1114966002135 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 1114966002136 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1114966002137 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1114966002138 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1114966002139 EamA-like transporter family; Region: EamA; pfam00892 1114966002140 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1114966002141 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1114966002142 active site 1114966002143 ATP binding site [chemical binding]; other site 1114966002144 substrate binding site [chemical binding]; other site 1114966002145 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1114966002146 substrate binding site [chemical binding]; other site 1114966002147 activation loop (A-loop); other site 1114966002148 activation loop (A-loop); other site 1114966002149 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607 1114966002150 active site 1114966002151 barstar interaction site; other site 1114966002152 Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141 1114966002153 putative RNAase interaction site [polypeptide binding]; other site 1114966002154 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1114966002155 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1114966002156 substrate binding pocket [chemical binding]; other site 1114966002157 chain length determination region; other site 1114966002158 substrate-Mg2+ binding site; other site 1114966002159 catalytic residues [active] 1114966002160 aspartate-rich region 1; other site 1114966002161 active site lid residues [active] 1114966002162 aspartate-rich region 2; other site 1114966002163 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246 1114966002164 Part of AAA domain; Region: AAA_19; pfam13245 1114966002165 Family description; Region: UvrD_C_2; pfam13538 1114966002166 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1114966002167 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1114966002168 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1114966002169 putative dimer interface [polypeptide binding]; other site 1114966002170 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1114966002171 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1114966002172 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114966002173 DNA-binding site [nucleotide binding]; DNA binding site 1114966002174 FCD domain; Region: FCD; pfam07729 1114966002175 glycine dehydrogenase; Provisional; Region: PRK05367 1114966002176 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1114966002177 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1114966002178 catalytic residue [active] 1114966002179 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1114966002180 tetramer interface [polypeptide binding]; other site 1114966002181 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114966002182 catalytic residue [active] 1114966002183 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1114966002184 lipoyl attachment site [posttranslational modification]; other site 1114966002185 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1114966002186 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 1114966002187 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1114966002188 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1114966002189 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1114966002190 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1114966002191 Protein of unknown function DUF58; Region: DUF58; pfam01882 1114966002192 MoxR-like ATPases [General function prediction only]; Region: COG0714 1114966002193 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114966002194 ATP binding site [chemical binding]; other site 1114966002195 Walker A motif; other site 1114966002196 Walker B motif; other site 1114966002197 arginine finger; other site 1114966002198 cell division protein MraZ; Reviewed; Region: PRK00326 1114966002199 MraZ protein; Region: MraZ; pfam02381 1114966002200 MraZ protein; Region: MraZ; pfam02381 1114966002201 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1114966002202 MraW methylase family; Region: Methyltransf_5; cl17771 1114966002203 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1114966002204 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 1114966002205 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1114966002206 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1114966002207 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1114966002208 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1114966002209 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1114966002210 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1114966002211 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1114966002212 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1114966002213 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1114966002214 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1114966002215 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1114966002216 Mg++ binding site [ion binding]; other site 1114966002217 putative catalytic motif [active] 1114966002218 putative substrate binding site [chemical binding]; other site 1114966002219 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438 1114966002220 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1114966002221 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1114966002222 cell division protein FtsW; Region: ftsW; TIGR02614 1114966002223 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1114966002224 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1114966002225 active site 1114966002226 homodimer interface [polypeptide binding]; other site 1114966002227 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1114966002228 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1114966002229 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1114966002230 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1114966002231 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1114966002232 Cell division protein FtsQ; Region: FtsQ; pfam03799 1114966002233 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 1114966002234 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1114966002235 nucleotide binding site [chemical binding]; other site 1114966002236 SulA interaction site; other site 1114966002237 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 1114966002238 Protein of unknown function (DUF552); Region: DUF552; pfam04472 1114966002239 DivIVA protein; Region: DivIVA; pfam05103 1114966002240 DivIVA domain; Region: DivI1A_domain; TIGR03544 1114966002241 V-type ATP synthase subunit E; Provisional; Region: PRK02292 1114966002242 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 1114966002243 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 1114966002244 lipoprotein signal peptidase; Provisional; Region: PRK14787 1114966002245 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1114966002246 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1114966002247 RNA binding surface [nucleotide binding]; other site 1114966002248 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1114966002249 active site 1114966002250 pyruvate kinase; Provisional; Region: PRK06247 1114966002251 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1114966002252 active site 1114966002253 domain interfaces; other site 1114966002254 CrcB-like protein; Region: CRCB; pfam02537 1114966002255 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 1114966002256 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 1114966002257 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114966002258 active site 1114966002259 phosphorylation site [posttranslational modification] 1114966002260 intermolecular recognition site; other site 1114966002261 dimerization interface [polypeptide binding]; other site 1114966002262 ANTAR domain; Region: ANTAR; pfam03861 1114966002263 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1114966002264 CoenzymeA binding site [chemical binding]; other site 1114966002265 subunit interaction site [polypeptide binding]; other site 1114966002266 PHB binding site; other site 1114966002267 DNA polymerase I; Provisional; Region: PRK05755 1114966002268 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1114966002269 active site 1114966002270 metal binding site 1 [ion binding]; metal-binding site 1114966002271 putative 5' ssDNA interaction site; other site 1114966002272 metal binding site 3; metal-binding site 1114966002273 metal binding site 2 [ion binding]; metal-binding site 1114966002274 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1114966002275 putative DNA binding site [nucleotide binding]; other site 1114966002276 putative metal binding site [ion binding]; other site 1114966002277 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1114966002278 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1114966002279 active site 1114966002280 DNA binding site [nucleotide binding] 1114966002281 catalytic site [active] 1114966002282 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1114966002283 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1114966002284 FAD binding domain; Region: FAD_binding_4; pfam01565 1114966002285 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 1114966002286 Hint domain; Region: Hint_2; pfam13403 1114966002287 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 1114966002288 active site 1114966002289 putative catalytic site [active] 1114966002290 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 1114966002291 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1114966002292 RNA binding site [nucleotide binding]; other site 1114966002293 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1114966002294 RNA binding site [nucleotide binding]; other site 1114966002295 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1114966002296 RNA binding site [nucleotide binding]; other site 1114966002297 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1114966002298 RNA binding site [nucleotide binding]; other site 1114966002299 domain interface; other site 1114966002300 Htaa; Region: HtaA; pfam04213 1114966002301 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 1114966002302 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1114966002303 intersubunit interface [polypeptide binding]; other site 1114966002304 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1114966002305 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1114966002306 ABC-ATPase subunit interface; other site 1114966002307 dimer interface [polypeptide binding]; other site 1114966002308 putative PBP binding regions; other site 1114966002309 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 1114966002310 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1114966002311 Walker A/P-loop; other site 1114966002312 ATP binding site [chemical binding]; other site 1114966002313 Q-loop/lid; other site 1114966002314 ABC transporter signature motif; other site 1114966002315 Walker B; other site 1114966002316 D-loop; other site 1114966002317 H-loop/switch region; other site 1114966002318 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1114966002319 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114966002320 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1114966002321 Walker A/P-loop; other site 1114966002322 ATP binding site [chemical binding]; other site 1114966002323 Q-loop/lid; other site 1114966002324 ABC transporter signature motif; other site 1114966002325 Walker B; other site 1114966002326 D-loop; other site 1114966002327 H-loop/switch region; other site 1114966002328 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1114966002329 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1114966002330 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114966002331 Walker A/P-loop; other site 1114966002332 ATP binding site [chemical binding]; other site 1114966002333 Q-loop/lid; other site 1114966002334 ABC transporter signature motif; other site 1114966002335 Walker B; other site 1114966002336 D-loop; other site 1114966002337 H-loop/switch region; other site 1114966002338 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1114966002339 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1114966002340 CoA-binding site [chemical binding]; other site 1114966002341 ATP-binding [chemical binding]; other site 1114966002342 Htaa; Region: HtaA; pfam04213 1114966002343 Htaa; Region: HtaA; pfam04213 1114966002344 Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081 1114966002345 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1114966002346 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 1114966002347 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1114966002348 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 1114966002349 metal ion-dependent adhesion site (MIDAS); other site 1114966002350 Domain of unknown function (DUF3479); Region: DUF3479; pfam11965 1114966002351 CobN/Magnesium Chelatase; Region: CobN-Mg_chel; pfam02514 1114966002352 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1114966002353 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1114966002354 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1114966002355 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1114966002356 Walker A/P-loop; other site 1114966002357 ATP binding site [chemical binding]; other site 1114966002358 Q-loop/lid; other site 1114966002359 ABC transporter signature motif; other site 1114966002360 Walker B; other site 1114966002361 D-loop; other site 1114966002362 H-loop/switch region; other site 1114966002363 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1114966002364 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1114966002365 ABC-ATPase subunit interface; other site 1114966002366 dimer interface [polypeptide binding]; other site 1114966002367 putative PBP binding regions; other site 1114966002368 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1114966002369 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1114966002370 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114966002371 ABC transporter signature motif; other site 1114966002372 Walker B; other site 1114966002373 D-loop; other site 1114966002374 H-loop/switch region; other site 1114966002375 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114966002376 Walker A/P-loop; other site 1114966002377 ATP binding site [chemical binding]; other site 1114966002378 Q-loop/lid; other site 1114966002379 Bacteriocin (Lactococcin_972); Region: Lactococcin_972; cl09891 1114966002380 excinuclease ABC subunit B; Provisional; Region: PRK05298 1114966002381 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1114966002382 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1114966002383 nucleotide binding region [chemical binding]; other site 1114966002384 ATP-binding site [chemical binding]; other site 1114966002385 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1114966002386 UvrB/uvrC motif; Region: UVR; pfam02151 1114966002387 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 1114966002388 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1114966002389 mycothiol-dependent maleylpyruvate isomerase; Reviewed; Region: PRK09583 1114966002390 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1114966002391 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1114966002392 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1114966002393 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1114966002394 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1114966002395 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1114966002396 iron-sulfur cluster [ion binding]; other site 1114966002397 [2Fe-2S] cluster binding site [ion binding]; other site 1114966002398 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1114966002399 catalytic core [active] 1114966002400 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1114966002401 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1114966002402 GIY-YIG motif/motif A; other site 1114966002403 active site 1114966002404 catalytic site [active] 1114966002405 putative DNA binding site [nucleotide binding]; other site 1114966002406 metal binding site [ion binding]; metal-binding site 1114966002407 UvrB/uvrC motif; Region: UVR; pfam02151 1114966002408 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1114966002409 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1114966002410 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1114966002411 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1114966002412 phosphate binding site [ion binding]; other site 1114966002413 putative substrate binding pocket [chemical binding]; other site 1114966002414 dimer interface [polypeptide binding]; other site 1114966002415 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1114966002416 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1114966002417 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1114966002418 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1114966002419 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1114966002420 Phosphoglycerate kinase; Region: PGK; pfam00162 1114966002421 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1114966002422 substrate binding site [chemical binding]; other site 1114966002423 hinge regions; other site 1114966002424 ADP binding site [chemical binding]; other site 1114966002425 catalytic site [active] 1114966002426 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1114966002427 triosephosphate isomerase; Provisional; Region: PRK14567 1114966002428 substrate binding site [chemical binding]; other site 1114966002429 dimer interface [polypeptide binding]; other site 1114966002430 catalytic triad [active] 1114966002431 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 1114966002432 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1114966002433 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1114966002434 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 1114966002435 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1114966002436 active site 1114966002437 multimer interface [polypeptide binding]; other site 1114966002438 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 1114966002439 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1114966002440 B12 binding site [chemical binding]; other site 1114966002441 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1114966002442 FeS/SAM binding site; other site 1114966002443 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 1114966002444 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105 1114966002445 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 1114966002446 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1114966002447 homodimer interface [polypeptide binding]; other site 1114966002448 oligonucleotide binding site [chemical binding]; other site 1114966002449 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1114966002450 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1114966002451 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1114966002452 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114966002453 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114966002454 putative substrate translocation pore; other site 1114966002455 GTPase CgtA; Reviewed; Region: obgE; PRK12296 1114966002456 GTP1/OBG; Region: GTP1_OBG; pfam01018 1114966002457 Obg GTPase; Region: Obg; cd01898 1114966002458 G1 box; other site 1114966002459 GTP/Mg2+ binding site [chemical binding]; other site 1114966002460 Switch I region; other site 1114966002461 G2 box; other site 1114966002462 G3 box; other site 1114966002463 Switch II region; other site 1114966002464 G4 box; other site 1114966002465 G5 box; other site 1114966002466 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1114966002467 gamma-glutamyl kinase; Provisional; Region: PRK05429 1114966002468 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1114966002469 nucleotide binding site [chemical binding]; other site 1114966002470 homotetrameric interface [polypeptide binding]; other site 1114966002471 putative phosphate binding site [ion binding]; other site 1114966002472 putative allosteric binding site; other site 1114966002473 PUA domain; Region: PUA; pfam01472 1114966002474 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1114966002475 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1114966002476 putative catalytic cysteine [active] 1114966002477 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1114966002478 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1114966002479 active site 1114966002480 (T/H)XGH motif; other site 1114966002481 Oligomerisation domain; Region: Oligomerisation; pfam02410 1114966002482 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1114966002483 catalytic core [active] 1114966002484 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1114966002485 substrate binding site [chemical binding]; other site 1114966002486 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114966002487 H-loop/switch region; other site 1114966002488 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1114966002489 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114966002490 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1114966002491 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1114966002492 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1114966002493 FtsX-like permease family; Region: FtsX; pfam02687 1114966002494 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1114966002495 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1114966002496 Walker A/P-loop; other site 1114966002497 ATP binding site [chemical binding]; other site 1114966002498 Q-loop/lid; other site 1114966002499 ABC transporter signature motif; other site 1114966002500 Walker B; other site 1114966002501 D-loop; other site 1114966002502 H-loop/switch region; other site 1114966002503 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1114966002504 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114966002505 ATP binding site [chemical binding]; other site 1114966002506 Mg2+ binding site [ion binding]; other site 1114966002507 G-X-G motif; other site 1114966002508 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1114966002509 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114966002510 active site 1114966002511 phosphorylation site [posttranslational modification] 1114966002512 intermolecular recognition site; other site 1114966002513 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1114966002514 DNA binding residues [nucleotide binding] 1114966002515 Uncharacterized conserved protein [Function unknown]; Region: COG5441; cl02262 1114966002516 Uncharacterized conserved protein [Function unknown]; Region: COG5441; cl02262 1114966002517 aspartate aminotransferase; Provisional; Region: PRK05764 1114966002518 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1114966002519 catalytic residue [active] 1114966002520 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1114966002521 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1114966002522 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114966002523 Walker A/P-loop; other site 1114966002524 ATP binding site [chemical binding]; other site 1114966002525 Q-loop/lid; other site 1114966002526 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114966002527 ABC transporter signature motif; other site 1114966002528 Walker B; other site 1114966002529 D-loop; other site 1114966002530 H-loop/switch region; other site 1114966002531 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114966002532 Walker A/P-loop; other site 1114966002533 ATP binding site [chemical binding]; other site 1114966002534 Q-loop/lid; other site 1114966002535 ABC transporter signature motif; other site 1114966002536 Walker B; other site 1114966002537 D-loop; other site 1114966002538 H-loop/switch region; other site 1114966002539 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1114966002540 MarR family; Region: MarR_2; pfam12802 1114966002541 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1114966002542 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1114966002543 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 1114966002544 active site 1114966002545 substrate binding pocket [chemical binding]; other site 1114966002546 homodimer interaction site [polypeptide binding]; other site 1114966002547 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 1114966002548 active site 1114966002549 dimer interface [polypeptide binding]; other site 1114966002550 magnesium binding site [ion binding]; other site 1114966002551 L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209 1114966002552 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1114966002553 AP (apurinic/apyrimidinic) site pocket; other site 1114966002554 DNA interaction; other site 1114966002555 Metal-binding active site; metal-binding site 1114966002556 L-ribulose-5-phosphate 4-epimerase; Validated; Region: PRK06557 1114966002557 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1114966002558 intersubunit interface [polypeptide binding]; other site 1114966002559 active site 1114966002560 Zn2+ binding site [ion binding]; other site 1114966002561 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1114966002562 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1114966002563 substrate binding site [chemical binding]; other site 1114966002564 ATP binding site [chemical binding]; other site 1114966002565 benzoate transport; Region: 2A0115; TIGR00895 1114966002566 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114966002567 putative substrate translocation pore; other site 1114966002568 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1114966002569 substrate binding site [chemical binding]; other site 1114966002570 multimerization interface [polypeptide binding]; other site 1114966002571 ATP binding site [chemical binding]; other site 1114966002572 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1114966002573 thiamine phosphate binding site [chemical binding]; other site 1114966002574 active site 1114966002575 pyrophosphate binding site [ion binding]; other site 1114966002576 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 1114966002577 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 1114966002578 dimer interface [polypeptide binding]; other site 1114966002579 NAD binding site [chemical binding]; other site 1114966002580 substrate binding site [chemical binding]; other site 1114966002581 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1114966002582 malate dehydrogenase; Provisional; Region: PRK13529 1114966002583 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1114966002584 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1114966002585 NAD(P) binding site [chemical binding]; other site 1114966002586 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 1114966002587 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 1114966002588 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1114966002589 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1114966002590 HIGH motif; other site 1114966002591 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1114966002592 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1114966002593 active site 1114966002594 KMSKS motif; other site 1114966002595 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1114966002596 tRNA binding surface [nucleotide binding]; other site 1114966002597 SLBB domain; Region: SLBB; pfam10531 1114966002598 comEA protein; Region: comE; TIGR01259 1114966002599 Helix-hairpin-helix motif; Region: HHH; pfam00633 1114966002600 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1114966002601 Competence protein; Region: Competence; pfam03772 1114966002602 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 1114966002603 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1114966002604 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1114966002605 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1114966002606 ATP binding site [chemical binding]; other site 1114966002607 putative Mg++ binding site [ion binding]; other site 1114966002608 hypothetical protein; Reviewed; Region: PRK07914 1114966002609 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1114966002610 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1114966002611 Alpha amylase catalytic domain found in Amylosucrase; Region: AmyAc_Amylosucrase; cd11324 1114966002612 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1114966002613 active site 1114966002614 catalytic site [active] 1114966002615 GTP-binding protein LepA; Provisional; Region: PRK05433 1114966002616 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1114966002617 G1 box; other site 1114966002618 putative GEF interaction site [polypeptide binding]; other site 1114966002619 GTP/Mg2+ binding site [chemical binding]; other site 1114966002620 Switch I region; other site 1114966002621 G2 box; other site 1114966002622 G3 box; other site 1114966002623 Switch II region; other site 1114966002624 G4 box; other site 1114966002625 G5 box; other site 1114966002626 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 1114966002627 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1114966002628 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1114966002629 O-succinylbenzoate synthase; Provisional; Region: PRK02901 1114966002630 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 1114966002631 active site 1114966002632 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase; Region: menD; TIGR00173 1114966002633 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1114966002634 dimer interface [polypeptide binding]; other site 1114966002635 tetramer interface [polypeptide binding]; other site 1114966002636 PYR/PP interface [polypeptide binding]; other site 1114966002637 TPP binding site [chemical binding]; other site 1114966002638 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1114966002639 TPP-binding site [chemical binding]; other site 1114966002640 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 1114966002641 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1114966002642 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1114966002643 acyl-activating enzyme (AAE) consensus motif; other site 1114966002644 AMP binding site [chemical binding]; other site 1114966002645 active site 1114966002646 CoA binding site [chemical binding]; other site 1114966002647 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1114966002648 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1114966002649 substrate binding site [chemical binding]; other site 1114966002650 oxyanion hole (OAH) forming residues; other site 1114966002651 trimer interface [polypeptide binding]; other site 1114966002652 Rhomboid family; Region: Rhomboid; pfam01694 1114966002653 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1114966002654 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1114966002655 acyl-activating enzyme (AAE) consensus motif; other site 1114966002656 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1114966002657 AMP binding site [chemical binding]; other site 1114966002658 active site 1114966002659 CoA binding site [chemical binding]; other site 1114966002660 coproporphyrinogen III oxidase; Validated; Region: PRK05628 1114966002661 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1114966002662 FeS/SAM binding site; other site 1114966002663 HemN C-terminal domain; Region: HemN_C; pfam06969 1114966002664 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 1114966002665 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1114966002666 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1114966002667 active site 1114966002668 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1114966002669 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1114966002670 chaperone protein DnaJ; Provisional; Region: PRK14278 1114966002671 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1114966002672 HSP70 interaction site [polypeptide binding]; other site 1114966002673 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1114966002674 Zn binding sites [ion binding]; other site 1114966002675 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1114966002676 dimer interface [polypeptide binding]; other site 1114966002677 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 1114966002678 RNA methyltransferase, RsmE family; Region: TIGR00046 1114966002679 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1114966002680 L-iditol 2-dehydrogenase; Region: iditol_2_DH_like; cd08235 1114966002681 putative NAD(P) binding site [chemical binding]; other site 1114966002682 catalytic Zn binding site [ion binding]; other site 1114966002683 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 1114966002684 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 1114966002685 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 1114966002686 active site 1114966002687 P-loop; other site 1114966002688 phosphorylation site [posttranslational modification] 1114966002689 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1114966002690 active site 1114966002691 phosphorylation site [posttranslational modification] 1114966002692 Predicted membrane protein [Function unknown]; Region: COG2259 1114966002693 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1114966002694 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1114966002695 ATP binding site [chemical binding]; other site 1114966002696 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1114966002697 putative Mg++ binding site [ion binding]; other site 1114966002698 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1114966002699 nucleotide binding region [chemical binding]; other site 1114966002700 ATP-binding site [chemical binding]; other site 1114966002701 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1114966002702 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1114966002703 EamA-like transporter family; Region: EamA; pfam00892 1114966002704 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 1114966002705 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1114966002706 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1114966002707 Histidine kinase; Region: HisKA_3; pfam07730 1114966002708 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1114966002709 potential frameshift: common BLAST hit: gi|295130489|ref|YP_003581152.1| transcriptional regulator, LuxR family 1114966002710 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 1114966002711 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114966002712 Walker A/P-loop; other site 1114966002713 ATP binding site [chemical binding]; other site 1114966002714 Q-loop/lid; other site 1114966002715 ABC transporter signature motif; other site 1114966002716 Walker B; other site 1114966002717 D-loop; other site 1114966002718 H-loop/switch region; other site 1114966002719 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1114966002720 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1114966002721 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 1114966002722 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 1114966002723 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1114966002724 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1114966002725 PhoH-like protein; Region: PhoH; pfam02562 1114966002726 metal-binding heat shock protein; Provisional; Region: PRK00016 1114966002727 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1114966002728 Domain of unknown function DUF21; Region: DUF21; pfam01595 1114966002729 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1114966002730 Transporter associated domain; Region: CorC_HlyC; smart01091 1114966002731 GTPase Era; Reviewed; Region: era; PRK00089 1114966002732 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1114966002733 G1 box; other site 1114966002734 GTP/Mg2+ binding site [chemical binding]; other site 1114966002735 Switch I region; other site 1114966002736 G2 box; other site 1114966002737 Switch II region; other site 1114966002738 G3 box; other site 1114966002739 G4 box; other site 1114966002740 G5 box; other site 1114966002741 KH domain; Region: KH_2; pfam07650 1114966002742 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1114966002743 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1114966002744 active site 1114966002745 2-isopropylmalate synthase; Validated; Region: PRK03739 1114966002746 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 1114966002747 active site 1114966002748 catalytic residues [active] 1114966002749 metal binding site [ion binding]; metal-binding site 1114966002750 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1114966002751 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1114966002752 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 1114966002753 catalytic residue [active] 1114966002754 putative FPP diphosphate binding site; other site 1114966002755 putative FPP binding hydrophobic cleft; other site 1114966002756 dimer interface [polypeptide binding]; other site 1114966002757 putative IPP diphosphate binding site; other site 1114966002758 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 1114966002759 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1114966002760 Recombination protein O N terminal; Region: RecO_N; pfam11967 1114966002761 Recombination protein O C terminal; Region: RecO_C; pfam02565 1114966002762 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1114966002763 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1114966002764 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114966002765 active site 1114966002766 phosphorylation site [posttranslational modification] 1114966002767 intermolecular recognition site; other site 1114966002768 dimerization interface [polypeptide binding]; other site 1114966002769 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1114966002770 DNA binding residues [nucleotide binding] 1114966002771 dimerization interface [polypeptide binding]; other site 1114966002772 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1114966002773 metal binding site 2 [ion binding]; metal-binding site 1114966002774 putative DNA binding helix; other site 1114966002775 metal binding site 1 [ion binding]; metal-binding site 1114966002776 dimer interface [polypeptide binding]; other site 1114966002777 structural Zn2+ binding site [ion binding]; other site 1114966002778 glycyl-tRNA synthetase; Provisional; Region: PRK04173 1114966002779 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1114966002780 motif 1; other site 1114966002781 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 1114966002782 active site 1114966002783 motif 2; other site 1114966002784 motif 3; other site 1114966002785 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 1114966002786 anticodon binding site; other site 1114966002787 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 1114966002788 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 1114966002789 proximal heme binding site [chemical binding]; other site 1114966002790 distal heme binding site [chemical binding]; other site 1114966002791 putative dimer interface [polypeptide binding]; other site 1114966002792 putative Iron-sulfur protein interface [polypeptide binding]; other site 1114966002793 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 1114966002794 L-aspartate oxidase; Provisional; Region: PRK06175 1114966002795 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1114966002796 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 1114966002797 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1114966002798 4Fe-4S binding domain; Region: Fer4; pfam00037 1114966002799 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 1114966002800 putative FMN binding site [chemical binding]; other site 1114966002801 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 1114966002802 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1114966002803 putative dimer interface [polypeptide binding]; other site 1114966002804 active site pocket [active] 1114966002805 putative cataytic base [active] 1114966002806 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1114966002807 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1114966002808 FMN binding site [chemical binding]; other site 1114966002809 active site 1114966002810 catalytic residues [active] 1114966002811 substrate binding site [chemical binding]; other site 1114966002812 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1114966002813 Zn2+ binding site [ion binding]; other site 1114966002814 Mg2+ binding site [ion binding]; other site 1114966002815 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1114966002816 Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424 1114966002817 DNA primase; Validated; Region: dnaG; PRK05667 1114966002818 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1114966002819 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1114966002820 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1114966002821 active site 1114966002822 metal binding site [ion binding]; metal-binding site 1114966002823 interdomain interaction site; other site 1114966002824 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1114966002825 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 1114966002826 DNA-directed RNA polymerase specialized sigma subunit [Transcription]; Region: FliA; COG1191 1114966002827 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1114966002828 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1114966002829 DNA binding residues [nucleotide binding] 1114966002830 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1114966002831 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 1114966002832 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1114966002833 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1114966002834 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 1114966002835 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 1114966002836 active site 1114966002837 homotetramer interface [polypeptide binding]; other site 1114966002838 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 1114966002839 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 1114966002840 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1114966002841 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1114966002842 dimer interface [polypeptide binding]; other site 1114966002843 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114966002844 catalytic residue [active] 1114966002845 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114966002846 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1114966002847 DNA-binding site [nucleotide binding]; DNA binding site 1114966002848 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1114966002849 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114966002850 homodimer interface [polypeptide binding]; other site 1114966002851 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1114966002852 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1114966002853 active site 1114966002854 multimer interface [polypeptide binding]; other site 1114966002855 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1114966002856 predicted active site [active] 1114966002857 catalytic triad [active] 1114966002858 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1114966002859 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 1114966002860 inhibitor-cofactor binding pocket; inhibition site 1114966002861 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114966002862 catalytic residue [active] 1114966002863 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1114966002864 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1114966002865 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1114966002866 potential protein location (hypothetical protein TIA2EST2_04750 [Propionibacterium acnes TypeIA2 P.acn33]) that overlaps RNA (tRNA-M) 1114966002867 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1114966002868 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1114966002869 active site 1114966002870 motif I; other site 1114966002871 motif II; other site 1114966002872 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1114966002873 MoxR-like ATPases [General function prediction only]; Region: COG0714 1114966002874 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114966002875 Walker A motif; other site 1114966002876 ATP binding site [chemical binding]; other site 1114966002877 Walker B motif; other site 1114966002878 arginine finger; other site 1114966002879 Protein of unknown function DUF58; Region: DUF58; pfam01882 1114966002880 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1114966002881 hypothetical protein; Provisional; Region: PRK13685 1114966002882 von Willebrand factor type A domain; Region: VWA_2; pfam13519 1114966002883 metal ion-dependent adhesion site (MIDAS); other site 1114966002884 Protein-interacting Bro1-like domain of mammalian Alix and related domains; Region: BRO1_Alix_like; cl14649 1114966002885 von Willebrand factor type A domain; Region: VWA_2; pfam13519 1114966002886 metal ion-dependent adhesion site (MIDAS); other site 1114966002887 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1114966002888 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1114966002889 catalytic residue [active] 1114966002890 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 1114966002891 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1114966002892 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1114966002893 dimer interface [polypeptide binding]; other site 1114966002894 active site 1114966002895 acyl carrier protein; Provisional; Region: acpP; PRK00982 1114966002896 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1114966002897 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1114966002898 dimer interface [polypeptide binding]; other site 1114966002899 active site 1114966002900 CoA binding pocket [chemical binding]; other site 1114966002901 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1114966002902 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1114966002903 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1114966002904 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1114966002905 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cl00252 1114966002906 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1114966002907 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114966002908 putative substrate translocation pore; other site 1114966002909 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114966002910 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1114966002911 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1114966002912 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1114966002913 dimer interface [polypeptide binding]; other site 1114966002914 TPP-binding site [chemical binding]; other site 1114966002915 Endo-beta-N-acetylglucosaminidases are bacterial chitinases that hydrolyze the chitin core of various asparagine (N)-linked glycans and glycoproteins. The endo-beta-N-acetylglucosaminidases have a glycosyl hydrolase family 18 (GH18) catalytic domain; Region: GH18_EndoS-like; cd06542 1114966002916 active site 1114966002917 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 1114966002918 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 1114966002919 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 1114966002920 Isochorismatase family; Region: Isochorismatase; pfam00857 1114966002921 catalytic triad [active] 1114966002922 metal binding site [ion binding]; metal-binding site 1114966002923 conserved cis-peptide bond; other site 1114966002924 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1114966002925 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1114966002926 active site 1114966002927 catalytic tetrad [active] 1114966002928 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1114966002929 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1114966002930 active site 1114966002931 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1114966002932 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1114966002933 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1114966002934 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1114966002935 dihydroorotase; Validated; Region: pyrC; PRK09357 1114966002936 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1114966002937 active site 1114966002938 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1114966002939 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 1114966002940 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1114966002941 catalytic site [active] 1114966002942 subunit interface [polypeptide binding]; other site 1114966002943 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1114966002944 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1114966002945 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1114966002946 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1114966002947 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1114966002948 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1114966002949 MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245 1114966002950 substrate binding site [chemical binding]; other site 1114966002951 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 1114966002952 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 1114966002953 FAD binding pocket [chemical binding]; other site 1114966002954 FAD binding motif [chemical binding]; other site 1114966002955 phosphate binding motif [ion binding]; other site 1114966002956 beta-alpha-beta structure motif; other site 1114966002957 NAD binding pocket [chemical binding]; other site 1114966002958 Iron coordination center [ion binding]; other site 1114966002959 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 1114966002960 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 1114966002961 heterodimer interface [polypeptide binding]; other site 1114966002962 active site 1114966002963 FMN binding site [chemical binding]; other site 1114966002964 homodimer interface [polypeptide binding]; other site 1114966002965 substrate binding site [chemical binding]; other site 1114966002966 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1114966002967 active site 1114966002968 dimer interface [polypeptide binding]; other site 1114966002969 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1114966002970 active site 1114966002971 Fructosamine kinase; Region: Fructosamin_kin; cl17579 1114966002972 Phosphotransferase enzyme family; Region: APH; pfam01636 1114966002973 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 1114966002974 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1114966002975 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1114966002976 Competence-damaged protein; Region: CinA; pfam02464 1114966002977 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1114966002978 non-specific DNA binding site [nucleotide binding]; other site 1114966002979 salt bridge; other site 1114966002980 sequence-specific DNA binding site [nucleotide binding]; other site 1114966002981 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1114966002982 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1114966002983 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1114966002984 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 1114966002985 recombinase A; Provisional; Region: recA; PRK09354 1114966002986 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1114966002987 hexamer interface [polypeptide binding]; other site 1114966002988 Walker A motif; other site 1114966002989 ATP binding site [chemical binding]; other site 1114966002990 Walker B motif; other site 1114966002991 recombination regulator RecX; Reviewed; Region: recX; PRK00117 1114966002992 hypothetical protein; Provisional; Region: PRK12705 1114966002993 KH domain; Region: KH_1; pfam00013 1114966002994 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1114966002995 Zn2+ binding site [ion binding]; other site 1114966002996 Mg2+ binding site [ion binding]; other site 1114966002997 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 1114966002998 active site 1114966002999 catalytic residues [active] 1114966003000 Predicted membrane protein [Function unknown]; Region: COG1288 1114966003001 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1114966003002 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 1114966003003 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1114966003004 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1114966003005 FeS/SAM binding site; other site 1114966003006 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 1114966003007 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1114966003008 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1114966003009 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1114966003010 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1114966003011 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1114966003012 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1114966003013 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1114966003014 HflX GTPase family; Region: HflX; cd01878 1114966003015 G1 box; other site 1114966003016 GTP/Mg2+ binding site [chemical binding]; other site 1114966003017 Switch I region; other site 1114966003018 G2 box; other site 1114966003019 G3 box; other site 1114966003020 Switch II region; other site 1114966003021 G4 box; other site 1114966003022 G5 box; other site 1114966003023 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1114966003024 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1114966003025 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1114966003026 putative Mg++ binding site [ion binding]; other site 1114966003027 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1114966003028 LexA repressor; Validated; Region: PRK00215 1114966003029 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1114966003030 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1114966003031 Catalytic site [active] 1114966003032 ATP cone domain; Region: ATP-cone; pfam03477 1114966003033 vitamin B12-dependent ribonucleotide reductase; Validated; Region: PRK06556 1114966003034 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 1114966003035 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 1114966003036 active site 1114966003037 dimer interface [polypeptide binding]; other site 1114966003038 effector binding site; other site 1114966003039 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1114966003040 TSCPD domain; Region: TSCPD; pfam12637 1114966003041 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1114966003042 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1114966003043 Ligand Binding Site [chemical binding]; other site 1114966003044 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1114966003045 Ligand Binding Site [chemical binding]; other site 1114966003046 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 1114966003047 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1114966003048 ATP binding site [chemical binding]; other site 1114966003049 putative Mg++ binding site [ion binding]; other site 1114966003050 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1114966003051 nucleotide binding region [chemical binding]; other site 1114966003052 ATP-binding site [chemical binding]; other site 1114966003053 Helicase associated domain (HA2); Region: HA2; pfam04408 1114966003054 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 1114966003055 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 1114966003056 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 1114966003057 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1114966003058 active site 1114966003059 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1114966003060 catalytic triad [active] 1114966003061 dimer interface [polypeptide binding]; other site 1114966003062 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 1114966003063 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1114966003064 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1114966003065 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1114966003066 Sigma-70, region 4; Region: Sigma70_r4; pfam04545 1114966003067 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 1114966003068 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1114966003069 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1114966003070 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1114966003071 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1114966003072 DNA binding residues [nucleotide binding] 1114966003073 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 1114966003074 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1114966003075 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1114966003076 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1114966003077 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114966003078 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1114966003079 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1114966003080 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1114966003081 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1114966003082 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1114966003083 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 1114966003084 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1114966003085 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1114966003086 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1114966003087 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 1114966003088 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114966003089 Mg2+ binding site [ion binding]; other site 1114966003090 G-X-G motif; other site 1114966003091 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1114966003092 anchoring element; other site 1114966003093 dimer interface [polypeptide binding]; other site 1114966003094 ATP binding site [chemical binding]; other site 1114966003095 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1114966003096 active site 1114966003097 metal binding site [ion binding]; metal-binding site 1114966003098 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1114966003099 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 1114966003100 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 1114966003101 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 1114966003102 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114966003103 putative substrate translocation pore; other site 1114966003104 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 1114966003105 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1114966003106 CAP-like domain; other site 1114966003107 active site 1114966003108 primary dimer interface [polypeptide binding]; other site 1114966003109 Uncharacterized conserved protein [Function unknown]; Region: COG4850 1114966003110 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 1114966003111 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 1114966003112 Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; cl17415 1114966003113 thymidine kinase; Provisional; Region: PRK04296 1114966003114 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 1114966003115 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 1114966003116 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 1114966003117 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 1114966003118 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1114966003119 trimer interface [polypeptide binding]; other site 1114966003120 active site 1114966003121 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 1114966003122 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1114966003123 ssDNA binding site; other site 1114966003124 generic binding surface II; other site 1114966003125 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1114966003126 TrkA-N domain; Region: TrkA_N; pfam02254 1114966003127 TrkA-C domain; Region: TrkA_C; pfam02080 1114966003128 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1114966003129 TrkA-N domain; Region: TrkA_N; pfam02254 1114966003130 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1114966003131 TRAM domain; Region: TRAM; cl01282 1114966003132 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1114966003133 aconitate hydratase; Validated; Region: PRK09277 1114966003134 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1114966003135 substrate binding site [chemical binding]; other site 1114966003136 ligand binding site [chemical binding]; other site 1114966003137 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1114966003138 substrate binding site [chemical binding]; other site 1114966003139 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1114966003140 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1114966003141 TPP-binding site; other site 1114966003142 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1114966003143 PYR/PP interface [polypeptide binding]; other site 1114966003144 dimer interface [polypeptide binding]; other site 1114966003145 TPP binding site [chemical binding]; other site 1114966003146 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1114966003147 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 1114966003148 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1114966003149 catalytic site [active] 1114966003150 putative active site [active] 1114966003151 putative substrate binding site [chemical binding]; other site 1114966003152 HRDC domain; Region: HRDC; pfam00570 1114966003153 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 1114966003154 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 1114966003155 SelR domain; Region: SelR; pfam01641 1114966003156 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 1114966003157 active site 1114966003158 YheO-like PAS domain; Region: PAS_6; pfam08348 1114966003159 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 1114966003160 HTH domain; Region: HTH_22; pfam13309 1114966003161 tryptophanase/L-cysteine desulfhydrase, PLP-dependent; Provisional; Region: tnaA; PRK13238 1114966003162 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1114966003163 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1114966003164 catalytic residue [active] 1114966003165 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1114966003166 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 1114966003167 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1114966003168 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1114966003169 putative NAD(P) binding site [chemical binding]; other site 1114966003170 putative substrate binding site [chemical binding]; other site 1114966003171 catalytic Zn binding site [ion binding]; other site 1114966003172 structural Zn binding site [ion binding]; other site 1114966003173 dimer interface [polypeptide binding]; other site 1114966003174 LrgB-like family; Region: LrgB; cl00596 1114966003175 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1114966003176 Histidine kinase; Region: HisKA_3; pfam07730 1114966003177 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114966003178 ATP binding site [chemical binding]; other site 1114966003179 Mg2+ binding site [ion binding]; other site 1114966003180 G-X-G motif; other site 1114966003181 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1114966003182 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114966003183 active site 1114966003184 phosphorylation site [posttranslational modification] 1114966003185 intermolecular recognition site; other site 1114966003186 dimerization interface [polypeptide binding]; other site 1114966003187 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1114966003188 DNA binding residues [nucleotide binding] 1114966003189 dimerization interface [polypeptide binding]; other site 1114966003190 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 1114966003191 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 1114966003192 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1114966003193 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1114966003194 active site 1114966003195 dimer interface [polypeptide binding]; other site 1114966003196 motif 1; other site 1114966003197 motif 2; other site 1114966003198 motif 3; other site 1114966003199 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1114966003200 anticodon binding site; other site 1114966003201 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 1114966003202 nucleotide binding site/active site [active] 1114966003203 HIT family signature motif; other site 1114966003204 catalytic residue [active] 1114966003205 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1114966003206 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1114966003207 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1114966003208 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 1114966003209 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 1114966003210 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1114966003211 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1114966003212 lipoyl attachment site [posttranslational modification]; other site 1114966003213 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1114966003214 Double zinc ribbon; Region: DZR; pfam12773 1114966003215 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1114966003216 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1114966003217 phosphopeptide binding site; other site 1114966003218 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1114966003219 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1114966003220 DNA binding residues [nucleotide binding] 1114966003221 Bifunctional nuclease; Region: DNase-RNase; pfam02577 1114966003222 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1114966003223 DNA binding residues [nucleotide binding] 1114966003224 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1114966003225 putative dimer interface [polypeptide binding]; other site 1114966003226 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 1114966003227 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114966003228 pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated; Region: PRK06555 1114966003229 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 1114966003230 active site 1114966003231 ADP/pyrophosphate binding site [chemical binding]; other site 1114966003232 fructose-1,6-bisphosphate binding site; other site 1114966003233 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 1114966003234 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1114966003235 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 1114966003236 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1114966003237 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1114966003238 Uncharacterized conserved protein [Function unknown]; Region: COG1739 1114966003239 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1114966003240 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1114966003241 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1114966003242 PAC2 family; Region: PAC2; pfam09754 1114966003243 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1114966003244 active site 1114966003245 acyl-CoA esterase; Provisional; Region: PRK10673 1114966003246 hypothetical protein; Provisional; Region: PRK03298 1114966003247 DivIVA protein; Region: DivIVA; pfam05103 1114966003248 V-type ATP synthase subunit E; Provisional; Region: PRK01558 1114966003249 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1114966003250 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 1114966003251 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1114966003252 dimer interface [polypeptide binding]; other site 1114966003253 substrate binding site [chemical binding]; other site 1114966003254 metal binding site [ion binding]; metal-binding site 1114966003255 phosphoglucomutase; Validated; Region: PRK07564 1114966003256 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 1114966003257 active site 1114966003258 substrate binding site [chemical binding]; other site 1114966003259 metal binding site [ion binding]; metal-binding site 1114966003260 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1114966003261 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 1114966003262 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1114966003263 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114966003264 motif II; other site 1114966003265 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1114966003266 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 1114966003267 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1114966003268 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1114966003269 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1114966003270 active site turn [active] 1114966003271 phosphorylation site [posttranslational modification] 1114966003272 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1114966003273 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 1114966003274 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1114966003275 HPr interaction site; other site 1114966003276 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1114966003277 active site 1114966003278 phosphorylation site [posttranslational modification] 1114966003279 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1114966003280 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1114966003281 nudix motif; other site 1114966003282 glycogen branching enzyme; Provisional; Region: PRK12313 1114966003283 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1114966003284 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1114966003285 active site 1114966003286 catalytic site [active] 1114966003287 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1114966003288 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 1114966003289 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 1114966003290 trehalose synthase; Region: treS_nterm; TIGR02456 1114966003291 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 1114966003292 active site 1114966003293 catalytic site [active] 1114966003294 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 1114966003295 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 1114966003296 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1114966003297 active site 1114966003298 homodimer interface [polypeptide binding]; other site 1114966003299 catalytic site [active] 1114966003300 acceptor binding site [chemical binding]; other site 1114966003301 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1114966003302 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1114966003303 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1114966003304 active site 1114966003305 catalytic site [active] 1114966003306 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1114966003307 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1114966003308 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1114966003309 catalytic residue [active] 1114966003310 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 1114966003311 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1114966003312 Ligand Binding Site [chemical binding]; other site 1114966003313 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 1114966003314 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 1114966003315 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1114966003316 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1114966003317 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1114966003318 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1114966003319 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1114966003320 GatB domain; Region: GatB_Yqey; smart00845 1114966003321 TIGR03085 family protein; Region: TIGR03085 1114966003322 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1114966003323 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1114966003324 anthranilate synthase component I; Provisional; Region: PRK13571 1114966003325 anthranilate synthase component I; Provisional; Region: PRK13571 1114966003326 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; cl17850 1114966003327 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1114966003328 active site 1114966003329 ribulose/triose binding site [chemical binding]; other site 1114966003330 phosphate binding site [ion binding]; other site 1114966003331 substrate (anthranilate) binding pocket [chemical binding]; other site 1114966003332 product (indole) binding pocket [chemical binding]; other site 1114966003333 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1114966003334 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1114966003335 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114966003336 catalytic residue [active] 1114966003337 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1114966003338 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1114966003339 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1114966003340 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1114966003341 active site 1114966003342 dimer interface [polypeptide binding]; other site 1114966003343 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1114966003344 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1114966003345 active site 1114966003346 FMN binding site [chemical binding]; other site 1114966003347 substrate binding site [chemical binding]; other site 1114966003348 3Fe-4S cluster binding site [ion binding]; other site 1114966003349 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1114966003350 domain interface; other site 1114966003351 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 1114966003352 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1114966003353 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1114966003354 Beta-lactamase; Region: Beta-lactamase; cl17358 1114966003355 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 1114966003356 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1114966003357 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1114966003358 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1114966003359 putative active site [active] 1114966003360 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 1114966003361 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1114966003362 putative active site [active] 1114966003363 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1114966003364 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 1114966003365 active site turn [active] 1114966003366 phosphorylation site [posttranslational modification] 1114966003367 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1114966003368 Uncharacterized conserved protein [Function unknown]; Region: COG3589 1114966003369 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1114966003370 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1114966003371 beta-galactosidase; Region: BGL; TIGR03356 1114966003372 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1114966003373 active site 1114966003374 P-loop; other site 1114966003375 phosphorylation site [posttranslational modification] 1114966003376 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1114966003377 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1114966003378 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1114966003379 methionine cluster; other site 1114966003380 active site 1114966003381 phosphorylation site [posttranslational modification] 1114966003382 metal binding site [ion binding]; metal-binding site 1114966003383 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1114966003384 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 1114966003385 active site 1114966003386 PHP Thumb interface [polypeptide binding]; other site 1114966003387 metal binding site [ion binding]; metal-binding site 1114966003388 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1114966003389 generic binding surface II; other site 1114966003390 generic binding surface I; other site 1114966003391 histidinol dehydrogenase; Region: hisD; TIGR00069 1114966003392 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1114966003393 NAD binding site [chemical binding]; other site 1114966003394 dimerization interface [polypeptide binding]; other site 1114966003395 product binding site; other site 1114966003396 substrate binding site [chemical binding]; other site 1114966003397 zinc binding site [ion binding]; other site 1114966003398 catalytic residues [active] 1114966003399 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 1114966003400 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1114966003401 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114966003402 homodimer interface [polypeptide binding]; other site 1114966003403 catalytic residue [active] 1114966003404 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1114966003405 putative active site pocket [active] 1114966003406 4-fold oligomerization interface [polypeptide binding]; other site 1114966003407 metal binding residues [ion binding]; metal-binding site 1114966003408 3-fold/trimer interface [polypeptide binding]; other site 1114966003409 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 1114966003410 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1114966003411 putative active site [active] 1114966003412 oxyanion strand; other site 1114966003413 catalytic triad [active] 1114966003414 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1114966003415 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 1114966003416 catalytic residues [active] 1114966003417 hypothetical protein; Validated; Region: PRK00110 1114966003418 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 1114966003419 active site 1114966003420 putative DNA-binding cleft [nucleotide binding]; other site 1114966003421 dimer interface [polypeptide binding]; other site 1114966003422 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1114966003423 RuvA N terminal domain; Region: RuvA_N; pfam01330 1114966003424 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1114966003425 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114966003426 Walker A motif; other site 1114966003427 ATP binding site [chemical binding]; other site 1114966003428 Walker B motif; other site 1114966003429 arginine finger; other site 1114966003430 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1114966003431 Preprotein translocase subunit; Region: YajC; pfam02699 1114966003432 Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342 1114966003433 Protein export membrane protein; Region: SecD_SecF; cl14618 1114966003434 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1114966003435 Protein export membrane protein; Region: SecD_SecF; pfam02355 1114966003436 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1114966003437 active site 1114966003438 potential frameshift: common BLAST hit: gi|295130723|ref|YP_003581386.1| Ion channel 1114966003439 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1114966003440 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1114966003441 Zn2+ binding site [ion binding]; other site 1114966003442 Mg2+ binding site [ion binding]; other site 1114966003443 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1114966003444 synthetase active site [active] 1114966003445 NTP binding site [chemical binding]; other site 1114966003446 metal binding site [ion binding]; metal-binding site 1114966003447 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1114966003448 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1114966003449 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1114966003450 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1114966003451 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1114966003452 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1114966003453 histidyl-tRNA synthetase; Region: hisS; TIGR00442 1114966003454 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1114966003455 dimer interface [polypeptide binding]; other site 1114966003456 motif 1; other site 1114966003457 active site 1114966003458 motif 2; other site 1114966003459 motif 3; other site 1114966003460 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1114966003461 anticodon binding site; other site 1114966003462 Protein of unknown function (DUF998); Region: DUF998; pfam06197 1114966003463 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1114966003464 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1114966003465 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1114966003466 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 1114966003467 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1114966003468 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 1114966003469 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 1114966003470 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 1114966003471 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1114966003472 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1114966003473 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1114966003474 dimer interface [polypeptide binding]; other site 1114966003475 anticodon binding site; other site 1114966003476 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1114966003477 homodimer interface [polypeptide binding]; other site 1114966003478 motif 1; other site 1114966003479 active site 1114966003480 motif 2; other site 1114966003481 GAD domain; Region: GAD; pfam02938 1114966003482 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1114966003483 active site 1114966003484 motif 3; other site 1114966003485 recombination factor protein RarA; Reviewed; Region: PRK13342 1114966003486 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114966003487 Walker A motif; other site 1114966003488 ATP binding site [chemical binding]; other site 1114966003489 Walker B motif; other site 1114966003490 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1114966003491 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1114966003492 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1114966003493 motif 1; other site 1114966003494 active site 1114966003495 motif 2; other site 1114966003496 motif 3; other site 1114966003497 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1114966003498 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 1114966003499 YceG-like family; Region: YceG; pfam02618 1114966003500 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1114966003501 dimerization interface [polypeptide binding]; other site 1114966003502 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1114966003503 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1114966003504 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1114966003505 shikimate binding site; other site 1114966003506 NAD(P) binding site [chemical binding]; other site 1114966003507 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1114966003508 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1114966003509 Tetramer interface [polypeptide binding]; other site 1114966003510 active site 1114966003511 FMN-binding site [chemical binding]; other site 1114966003512 shikimate kinase; Reviewed; Region: aroK; PRK00131 1114966003513 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1114966003514 ADP binding site [chemical binding]; other site 1114966003515 magnesium binding site [ion binding]; other site 1114966003516 putative shikimate binding site; other site 1114966003517 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1114966003518 dimer interface [polypeptide binding]; other site 1114966003519 active site 1114966003520 metal binding site [ion binding]; metal-binding site 1114966003521 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 1114966003522 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 1114966003523 putative active site [active] 1114966003524 putative metal binding site [ion binding]; other site 1114966003525 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 1114966003526 elongation factor P; Validated; Region: PRK00529 1114966003527 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1114966003528 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1114966003529 RNA binding site [nucleotide binding]; other site 1114966003530 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1114966003531 RNA binding site [nucleotide binding]; other site 1114966003532 transcription antitermination factor NusB; Region: nusB; TIGR01951 1114966003533 putative RNA binding site [nucleotide binding]; other site 1114966003534 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1114966003535 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1114966003536 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1114966003537 catalytic site [active] 1114966003538 G-X2-G-X-G-K; other site 1114966003539 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 1114966003540 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1114966003541 Flavoprotein; Region: Flavoprotein; pfam02441 1114966003542 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1114966003543 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1114966003544 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1114966003545 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1114966003546 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1114966003547 primosome assembly protein PriA; Provisional; Region: PRK14873 1114966003548 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1114966003549 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1114966003550 putative active site [active] 1114966003551 substrate binding site [chemical binding]; other site 1114966003552 putative cosubstrate binding site; other site 1114966003553 catalytic site [active] 1114966003554 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1114966003555 substrate binding site [chemical binding]; other site 1114966003556 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 1114966003557 putative RNA binding site [nucleotide binding]; other site 1114966003558 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1114966003559 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114966003560 S-adenosylmethionine binding site [chemical binding]; other site 1114966003561 CAMP factor (Cfa); Region: CAMP_factor; pfam07373 1114966003562 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1114966003563 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1114966003564 substrate binding site [chemical binding]; other site 1114966003565 hexamer interface [polypeptide binding]; other site 1114966003566 metal binding site [ion binding]; metal-binding site 1114966003567 PAC2 family; Region: PAC2; pfam09754 1114966003568 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1114966003569 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1114966003570 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114966003571 motif II; other site 1114966003572 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 1114966003573 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114966003574 S-adenosylmethionine binding site [chemical binding]; other site 1114966003575 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 1114966003576 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1114966003577 Predicted membrane protein [Function unknown]; Region: COG1511 1114966003578 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1114966003579 ABC transporter; Region: ABC_tran; pfam00005 1114966003580 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1114966003581 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114966003582 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1114966003583 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 1114966003584 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 1114966003585 active site 1114966003586 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 1114966003587 prephenate dehydrogenase; Validated; Region: PRK06545 1114966003588 prephenate dehydrogenase; Validated; Region: PRK08507 1114966003589 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cd02116 1114966003590 cytidylate kinase; Provisional; Region: cmk; PRK00023 1114966003591 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1114966003592 CMP-binding site; other site 1114966003593 GTP-binding protein Der; Reviewed; Region: PRK03003 1114966003594 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1114966003595 G1 box; other site 1114966003596 GTP/Mg2+ binding site [chemical binding]; other site 1114966003597 Switch I region; other site 1114966003598 G2 box; other site 1114966003599 Switch II region; other site 1114966003600 G3 box; other site 1114966003601 G4 box; other site 1114966003602 G5 box; other site 1114966003603 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1114966003604 G1 box; other site 1114966003605 GTP/Mg2+ binding site [chemical binding]; other site 1114966003606 Switch I region; other site 1114966003607 G2 box; other site 1114966003608 G3 box; other site 1114966003609 Switch II region; other site 1114966003610 G4 box; other site 1114966003611 G5 box; other site 1114966003612 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1114966003613 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1114966003614 substrate binding site [chemical binding]; other site 1114966003615 dimer interface [polypeptide binding]; other site 1114966003616 ATP binding site [chemical binding]; other site 1114966003617 deoxyribose mutarotase_like; Region: deoxyribose_mutarotase; cd09269 1114966003618 active site 1114966003619 catalytic residues [active] 1114966003620 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 1114966003621 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114966003622 putative substrate translocation pore; other site 1114966003623 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1114966003624 intersubunit interface [polypeptide binding]; other site 1114966003625 active site 1114966003626 catalytic residue [active] 1114966003627 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1114966003628 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1114966003629 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114966003630 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1114966003631 active site 1114966003632 motif I; other site 1114966003633 motif II; other site 1114966003634 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1114966003635 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 1114966003636 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1114966003637 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1114966003638 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1114966003639 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1114966003640 putative DNA binding site [nucleotide binding]; other site 1114966003641 putative Zn2+ binding site [ion binding]; other site 1114966003642 AsnC family; Region: AsnC_trans_reg; pfam01037 1114966003643 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 1114966003644 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1114966003645 putative active site [active] 1114966003646 catalytic triad [active] 1114966003647 putative dimer interface [polypeptide binding]; other site 1114966003648 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 1114966003649 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 1114966003650 Ligand binding site; other site 1114966003651 Putative Catalytic site; other site 1114966003652 DXD motif; other site 1114966003653 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 1114966003654 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 1114966003655 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1114966003656 putative active site [active] 1114966003657 catalytic site [active] 1114966003658 putative metal binding site [ion binding]; other site 1114966003659 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 1114966003660 dimer interface [polypeptide binding]; other site 1114966003661 pyridoxamine kinase; Validated; Region: PRK05756 1114966003662 pyridoxal binding site [chemical binding]; other site 1114966003663 ATP binding site [chemical binding]; other site 1114966003664 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1114966003665 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1114966003666 non-specific DNA binding site [nucleotide binding]; other site 1114966003667 salt bridge; other site 1114966003668 sequence-specific DNA binding site [nucleotide binding]; other site 1114966003669 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1114966003670 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 1114966003671 putative active site [active] 1114966003672 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 1114966003673 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1114966003674 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1114966003675 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1114966003676 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1114966003677 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1114966003678 dimerization interface [polypeptide binding]; other site 1114966003679 putative DNA binding site [nucleotide binding]; other site 1114966003680 putative Zn2+ binding site [ion binding]; other site 1114966003681 CAMP factor (Cfa); Region: CAMP_factor; pfam07373 1114966003682 hypothetical protein; Provisional; Region: PRK09256 1114966003683 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1114966003684 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114966003685 putative substrate translocation pore; other site 1114966003686 MarR family; Region: MarR; pfam01047 1114966003687 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 1114966003688 Fe-S cluster binding site [ion binding]; other site 1114966003689 DNA binding site [nucleotide binding] 1114966003690 active site 1114966003691 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 1114966003692 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 1114966003693 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1114966003694 gamma subunit interface [polypeptide binding]; other site 1114966003695 epsilon subunit interface [polypeptide binding]; other site 1114966003696 LBP interface [polypeptide binding]; other site 1114966003697 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1114966003698 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1114966003699 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1114966003700 alpha subunit interaction interface [polypeptide binding]; other site 1114966003701 Walker A motif; other site 1114966003702 ATP binding site [chemical binding]; other site 1114966003703 Walker B motif; other site 1114966003704 inhibitor binding site; inhibition site 1114966003705 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1114966003706 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1114966003707 core domain interface [polypeptide binding]; other site 1114966003708 delta subunit interface [polypeptide binding]; other site 1114966003709 epsilon subunit interface [polypeptide binding]; other site 1114966003710 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1114966003711 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1114966003712 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1114966003713 beta subunit interaction interface [polypeptide binding]; other site 1114966003714 Walker A motif; other site 1114966003715 ATP binding site [chemical binding]; other site 1114966003716 Walker B motif; other site 1114966003717 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1114966003718 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210 1114966003719 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1114966003720 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1114966003721 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1114966003722 F0F1 ATP synthase subunit C; Validated; Region: PRK07558 1114966003723 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1114966003724 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1114966003725 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 1114966003726 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1114966003727 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1114966003728 putative catalytic motif [active] 1114966003729 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1114966003730 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 1114966003731 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114966003732 S-adenosylmethionine binding site [chemical binding]; other site 1114966003733 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1114966003734 PCRF domain; Region: PCRF; pfam03462 1114966003735 RF-1 domain; Region: RF-1; pfam00472 1114966003736 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1114966003737 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1114966003738 transcription termination factor Rho; Provisional; Region: PRK12608 1114966003739 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1114966003740 RNA binding site [nucleotide binding]; other site 1114966003741 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1114966003742 Walker A motif; other site 1114966003743 ATP binding site [chemical binding]; other site 1114966003744 Walker B motif; other site 1114966003745 homoserine kinase; Provisional; Region: PRK01212 1114966003746 threonine synthase; Reviewed; Region: PRK06721 1114966003747 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1114966003748 homodimer interface [polypeptide binding]; other site 1114966003749 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114966003750 catalytic residue [active] 1114966003751 homoserine dehydrogenase; Provisional; Region: PRK06349 1114966003752 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1114966003753 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1114966003754 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1114966003755 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1114966003756 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1114966003757 active site 1114966003758 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1114966003759 substrate binding site [chemical binding]; other site 1114966003760 catalytic residues [active] 1114966003761 dimer interface [polypeptide binding]; other site 1114966003762 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 1114966003763 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1114966003764 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1114966003765 TPP-binding site [chemical binding]; other site 1114966003766 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1114966003767 Transcription factor WhiB; Region: Whib; pfam02467 1114966003768 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 1114966003769 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1114966003770 Histidine kinase; Region: HisKA_2; pfam07568 1114966003771 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114966003772 ATP binding site [chemical binding]; other site 1114966003773 Mg2+ binding site [ion binding]; other site 1114966003774 G-X-G motif; other site 1114966003775 anti-sigma factor, TIGR02949 family; Region: anti_SigH_actin 1114966003776 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 1114966003777 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1114966003778 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1114966003779 DNA binding residues [nucleotide binding] 1114966003780 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1114966003781 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1114966003782 hinge; other site 1114966003783 active site 1114966003784 Predicted GTPases [General function prediction only]; Region: COG1162 1114966003785 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1114966003786 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1114966003787 GTP/Mg2+ binding site [chemical binding]; other site 1114966003788 G4 box; other site 1114966003789 G5 box; other site 1114966003790 G1 box; other site 1114966003791 Switch I region; other site 1114966003792 G2 box; other site 1114966003793 G3 box; other site 1114966003794 Switch II region; other site 1114966003795 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 1114966003796 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1114966003797 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 1114966003798 active site 1114966003799 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 1114966003800 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 1114966003801 ligand binding site [chemical binding]; other site 1114966003802 NAD binding site [chemical binding]; other site 1114966003803 tetramer interface [polypeptide binding]; other site 1114966003804 catalytic site [active] 1114966003805 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 1114966003806 L-serine binding site [chemical binding]; other site 1114966003807 ACT domain interface; other site 1114966003808 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1114966003809 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1114966003810 Walker A/P-loop; other site 1114966003811 ATP binding site [chemical binding]; other site 1114966003812 Q-loop/lid; other site 1114966003813 ABC transporter signature motif; other site 1114966003814 Walker B; other site 1114966003815 D-loop; other site 1114966003816 H-loop/switch region; other site 1114966003817 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1114966003818 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1114966003819 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1114966003820 Walker A/P-loop; other site 1114966003821 ATP binding site [chemical binding]; other site 1114966003822 Q-loop/lid; other site 1114966003823 ABC transporter signature motif; other site 1114966003824 Walker B; other site 1114966003825 D-loop; other site 1114966003826 H-loop/switch region; other site 1114966003827 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1114966003828 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114966003829 dimer interface [polypeptide binding]; other site 1114966003830 conserved gate region; other site 1114966003831 putative PBP binding loops; other site 1114966003832 ABC-ATPase subunit interface; other site 1114966003833 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1114966003834 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114966003835 dimer interface [polypeptide binding]; other site 1114966003836 conserved gate region; other site 1114966003837 putative PBP binding loops; other site 1114966003838 ABC-ATPase subunit interface; other site 1114966003839 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1114966003840 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 1114966003841 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1114966003842 sequence-specific DNA binding site [nucleotide binding]; other site 1114966003843 salt bridge; other site 1114966003844 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1114966003845 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1114966003846 Magnesium ion binding site [ion binding]; other site 1114966003847 Domain of unknown function (DUF929); Region: DUF929; pfam06053 1114966003848 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1114966003849 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1114966003850 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1114966003851 AMP binding site [chemical binding]; other site 1114966003852 active site 1114966003853 acyl-activating enzyme (AAE) consensus motif; other site 1114966003854 CoA binding site [chemical binding]; other site 1114966003855 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1114966003856 Condensation domain; Region: Condensation; pfam00668 1114966003857 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1114966003858 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1114966003859 2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944 1114966003860 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1114966003861 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 1114966003862 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1114966003863 dimer interface [polypeptide binding]; other site 1114966003864 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114966003865 catalytic residue [active] 1114966003866 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1114966003867 ParB-like nuclease domain; Region: ParBc; cl02129 1114966003868 precorrin-3B synthase; Region: CobG; TIGR02435 1114966003869 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1114966003870 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 1114966003871 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 1114966003872 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1114966003873 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 1114966003874 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1114966003875 Ligand Binding Site [chemical binding]; other site 1114966003876 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 1114966003877 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1114966003878 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1114966003879 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 1114966003880 Protein of unknown function DUF45; Region: DUF45; pfam01863 1114966003881 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1114966003882 Part of AAA domain; Region: AAA_19; pfam13245 1114966003883 Family description; Region: UvrD_C_2; pfam13538 1114966003884 HRDC domain; Region: HRDC; pfam00570 1114966003885 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 1114966003886 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 1114966003887 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 1114966003888 Part of AAA domain; Region: AAA_19; pfam13245 1114966003889 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1114966003890 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 1114966003891 AAA domain; Region: AAA_30; pfam13604 1114966003892 Family description; Region: UvrD_C_2; pfam13538 1114966003893 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 1114966003894 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1114966003895 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1114966003896 putative NADH binding site [chemical binding]; other site 1114966003897 putative active site [active] 1114966003898 nudix motif; other site 1114966003899 putative metal binding site [ion binding]; other site 1114966003900 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1114966003901 Part of AAA domain; Region: AAA_19; pfam13245 1114966003902 Family description; Region: UvrD_C_2; pfam13538 1114966003903 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1114966003904 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1114966003905 Part of AAA domain; Region: AAA_19; pfam13245 1114966003906 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1114966003907 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1114966003908 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1114966003909 active site 1114966003910 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 1114966003911 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 1114966003912 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1114966003913 ATP binding site [chemical binding]; other site 1114966003914 Mg++ binding site [ion binding]; other site 1114966003915 motif III; other site 1114966003916 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1114966003917 nucleotide binding region [chemical binding]; other site 1114966003918 ATP-binding site [chemical binding]; other site 1114966003919 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1114966003920 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1114966003921 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1114966003922 active site 1114966003923 HIGH motif; other site 1114966003924 dimer interface [polypeptide binding]; other site 1114966003925 KMSKS motif; other site 1114966003926 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 1114966003927 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1114966003928 active site 1114966003929 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1114966003930 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 1114966003931 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 1114966003932 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1114966003933 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1114966003934 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1114966003935 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1114966003936 30S subunit binding site; other site 1114966003937 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1114966003938 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1114966003939 active site 1114966003940 Sporulation and spore germination; Region: Germane; cl11253 1114966003941 Lipoprotein LpqB beta-propeller domain; Region: Gmad1; pfam10647 1114966003942 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1114966003943 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114966003944 dimerization interface [polypeptide binding]; other site 1114966003945 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114966003946 dimer interface [polypeptide binding]; other site 1114966003947 phosphorylation site [posttranslational modification] 1114966003948 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114966003949 ATP binding site [chemical binding]; other site 1114966003950 Mg2+ binding site [ion binding]; other site 1114966003951 G-X-G motif; other site 1114966003952 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1114966003953 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114966003954 active site 1114966003955 phosphorylation site [posttranslational modification] 1114966003956 intermolecular recognition site; other site 1114966003957 dimerization interface [polypeptide binding]; other site 1114966003958 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1114966003959 DNA binding site [nucleotide binding] 1114966003960 hypothetical protein; Validated; Region: PRK00228 1114966003961 CAMP factor (Cfa); Region: CAMP_factor; pfam07373 1114966003962 ribbon-helix-helix domain containing protein; Region: PHA00617 1114966003963 Protein of unknown function (DUF1706); Region: DUF1706; cl01748 1114966003964 Protein of unknown function (DUF1706); Region: DUF1706; cl01748 1114966003965 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 1114966003966 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1114966003967 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1114966003968 Tic20-like protein; Region: Tic20; pfam09685 1114966003969 argininosuccinate lyase; Provisional; Region: PRK00855 1114966003970 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1114966003971 active sites [active] 1114966003972 tetramer interface [polypeptide binding]; other site 1114966003973 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 1114966003974 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1114966003975 inhibitor-cofactor binding pocket; inhibition site 1114966003976 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114966003977 catalytic residue [active] 1114966003978 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 1114966003979 feedback inhibition sensing region; other site 1114966003980 homohexameric interface [polypeptide binding]; other site 1114966003981 nucleotide binding site [chemical binding]; other site 1114966003982 N-acetyl-L-glutamate binding site [chemical binding]; other site 1114966003983 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1114966003984 heterotetramer interface [polypeptide binding]; other site 1114966003985 active site pocket [active] 1114966003986 cleavage site 1114966003987 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1114966003988 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1114966003989 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1114966003990 SmpB-tmRNA interface; other site 1114966003991 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1114966003992 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1114966003993 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1114966003994 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114966003995 Walker A/P-loop; other site 1114966003996 ATP binding site [chemical binding]; other site 1114966003997 Q-loop/lid; other site 1114966003998 ABC transporter signature motif; other site 1114966003999 Walker B; other site 1114966004000 D-loop; other site 1114966004001 H-loop/switch region; other site 1114966004002 peptide chain release factor 2; Validated; Region: prfB; PRK00578 1114966004003 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1114966004004 RF-1 domain; Region: RF-1; pfam00472 1114966004005 Protein of unknown function (DUF805); Region: DUF805; pfam05656 1114966004006 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1114966004007 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1114966004008 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1114966004009 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1114966004010 thiamine monophosphate kinase; Provisional; Region: PRK05731 1114966004011 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1114966004012 ATP binding site [chemical binding]; other site 1114966004013 dimerization interface [polypeptide binding]; other site 1114966004014 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 1114966004015 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1114966004016 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1114966004017 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1114966004018 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1114966004019 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1114966004020 putative acyl-acceptor binding pocket; other site 1114966004021 hypothetical protein; Provisional; Region: PRK14812 1114966004022 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1114966004023 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1114966004024 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1114966004025 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1114966004026 Bacterial transcriptional regulator; Region: IclR; pfam01614 1114966004027 CAAX protease self-immunity; Region: Abi; pfam02517 1114966004028 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 1114966004029 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1114966004030 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1114966004031 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 1114966004032 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1114966004033 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1114966004034 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 1114966004035 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1114966004036 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1114966004037 homodimer interface [polypeptide binding]; other site 1114966004038 substrate-cofactor binding pocket; other site 1114966004039 catalytic residue [active] 1114966004040 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 1114966004041 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 1114966004042 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1114966004043 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1114966004044 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1114966004045 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1114966004046 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1114966004047 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1114966004048 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1114966004049 HIT family signature motif; other site 1114966004050 catalytic residue [active] 1114966004051 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1114966004052 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1114966004053 substrate binding site [chemical binding]; other site 1114966004054 glutamase interaction surface [polypeptide binding]; other site 1114966004055 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 1114966004056 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1114966004057 ATP binding site [chemical binding]; other site 1114966004058 putative Mg++ binding site [ion binding]; other site 1114966004059 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1114966004060 nucleotide binding region [chemical binding]; other site 1114966004061 ATP-binding site [chemical binding]; other site 1114966004062 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 1114966004063 Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902 1114966004064 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 1114966004065 Predicted transcriptional regulator [Transcription]; Region: COG2378 1114966004066 WYL domain; Region: WYL; pfam13280 1114966004067 Predicted transcriptional regulator [Transcription]; Region: COG2378 1114966004068 WYL domain; Region: WYL; pfam13280 1114966004069 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1114966004070 active site 1114966004071 HIGH motif; other site 1114966004072 nucleotide binding site [chemical binding]; other site 1114966004073 active site 1114966004074 KMSKS motif; other site 1114966004075 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1114966004076 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1114966004077 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1114966004078 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1114966004079 RNA binding surface [nucleotide binding]; other site 1114966004080 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1114966004081 active site 1114966004082 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1114966004083 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1114966004084 P-loop; other site 1114966004085 Magnesium ion binding site [ion binding]; other site 1114966004086 transport-energizing ATPase, TRC40/GET3/ArsA family; Region: GET3_arsA_TRC40; TIGR00345 1114966004087 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1114966004088 Magnesium ion binding site [ion binding]; other site 1114966004089 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1114966004090 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1114966004091 active site 1114966004092 Int/Topo IB signature motif; other site 1114966004093 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1114966004094 dimer interface [polypeptide binding]; other site 1114966004095 ADP-ribose binding site [chemical binding]; other site 1114966004096 active site 1114966004097 nudix motif; other site 1114966004098 metal binding site [ion binding]; metal-binding site 1114966004099 CTP synthetase; Validated; Region: pyrG; PRK05380 1114966004100 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1114966004101 Catalytic site [active] 1114966004102 active site 1114966004103 UTP binding site [chemical binding]; other site 1114966004104 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1114966004105 active site 1114966004106 putative oxyanion hole; other site 1114966004107 catalytic triad [active] 1114966004108 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1114966004109 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114966004110 Walker A/P-loop; other site 1114966004111 ATP binding site [chemical binding]; other site 1114966004112 Q-loop/lid; other site 1114966004113 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1114966004114 ABC transporter signature motif; other site 1114966004115 Walker B; other site 1114966004116 D-loop; other site 1114966004117 H-loop/switch region; other site 1114966004118 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 1114966004119 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1114966004120 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1114966004121 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1114966004122 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1114966004123 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1114966004124 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1114966004125 Walker A/P-loop; other site 1114966004126 ATP binding site [chemical binding]; other site 1114966004127 Q-loop/lid; other site 1114966004128 ABC transporter signature motif; other site 1114966004129 Walker B; other site 1114966004130 D-loop; other site 1114966004131 H-loop/switch region; other site 1114966004132 BioY family; Region: BioY; pfam02632 1114966004133 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1114966004134 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114966004135 active site 1114966004136 motif I; other site 1114966004137 motif II; other site 1114966004138 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1114966004139 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1114966004140 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1114966004141 TPR motif; other site 1114966004142 binding surface 1114966004143 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1114966004144 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1114966004145 active site 1114966004146 HIGH motif; other site 1114966004147 dimer interface [polypeptide binding]; other site 1114966004148 KMSKS motif; other site 1114966004149 arginine repressor; Provisional; Region: PRK03341 1114966004150 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1114966004151 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1114966004152 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114966004153 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1114966004154 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1114966004155 biotin synthase; Validated; Region: PRK06256 1114966004156 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1114966004157 FeS/SAM binding site; other site 1114966004158 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1114966004159 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1114966004160 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1114966004161 putative tRNA-binding site [nucleotide binding]; other site 1114966004162 B3/4 domain; Region: B3_4; pfam03483 1114966004163 tRNA synthetase B5 domain; Region: B5; pfam03484 1114966004164 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1114966004165 dimer interface [polypeptide binding]; other site 1114966004166 motif 1; other site 1114966004167 motif 3; other site 1114966004168 motif 2; other site 1114966004169 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1114966004170 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1114966004171 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1114966004172 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1114966004173 dimer interface [polypeptide binding]; other site 1114966004174 motif 1; other site 1114966004175 active site 1114966004176 motif 2; other site 1114966004177 motif 3; other site 1114966004178 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1114966004179 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 1114966004180 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1114966004181 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1114966004182 23S rRNA binding site [nucleotide binding]; other site 1114966004183 L21 binding site [polypeptide binding]; other site 1114966004184 L13 binding site [polypeptide binding]; other site 1114966004185 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1114966004186 translation initiation factor IF-3; Region: infC; TIGR00168 1114966004187 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1114966004188 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1114966004189 Protein of unknown function (DUF418); Region: DUF418; cl12135 1114966004190 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 1114966004191 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 1114966004192 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 1114966004193 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 1114966004194 homodimer interface [polypeptide binding]; other site 1114966004195 putative metal binding site [ion binding]; other site 1114966004196 Nicotinamide mononucleotide transporter [Coenzyme metabolism]; Region: PnuC; COG3201 1114966004197 conserved hypothetical protein; Region: TIGR03843 1114966004198 conserved hypothetical protein; Region: TIGR03847 1114966004199 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1114966004200 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1114966004201 active site 1114966004202 catalytic tetrad [active] 1114966004203 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1114966004204 dimer interface [polypeptide binding]; other site 1114966004205 Citrate synthase; Region: Citrate_synt; pfam00285 1114966004206 active site 1114966004207 citrylCoA binding site [chemical binding]; other site 1114966004208 NADH binding [chemical binding]; other site 1114966004209 cationic pore residues; other site 1114966004210 oxalacetate/citrate binding site [chemical binding]; other site 1114966004211 coenzyme A binding site [chemical binding]; other site 1114966004212 catalytic triad [active] 1114966004213 hypothetical protein; Provisional; Region: PRK07906 1114966004214 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 1114966004215 putative metal binding site [ion binding]; other site 1114966004216 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1114966004217 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1114966004218 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1114966004219 CsbD-like; Region: CsbD; pfam05532 1114966004220 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1114966004221 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1114966004222 DNA binding site [nucleotide binding] 1114966004223 active site 1114966004224 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1114966004225 DNA protecting protein DprA; Region: dprA; TIGR00732 1114966004226 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1114966004227 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1114966004228 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114966004229 Walker A motif; other site 1114966004230 ATP binding site [chemical binding]; other site 1114966004231 Walker B motif; other site 1114966004232 arginine finger; other site 1114966004233 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1114966004234 hypothetical protein; Reviewed; Region: PRK12497 1114966004235 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 1114966004236 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1114966004237 RNA/DNA hybrid binding site [nucleotide binding]; other site 1114966004238 active site 1114966004239 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1114966004240 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1114966004241 Catalytic site [active] 1114966004242 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1114966004243 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 1114966004244 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1114966004245 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1114966004246 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 1114966004247 L-aspartate oxidase; Provisional; Region: PRK06175 1114966004248 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1114966004249 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 1114966004250 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 1114966004251 putative Iron-sulfur protein interface [polypeptide binding]; other site 1114966004252 proximal heme binding site [chemical binding]; other site 1114966004253 distal heme binding site [chemical binding]; other site 1114966004254 putative dimer interface [polypeptide binding]; other site 1114966004255 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1114966004256 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1114966004257 RimM N-terminal domain; Region: RimM; pfam01782 1114966004258 PRC-barrel domain; Region: PRC; pfam05239 1114966004259 hypothetical protein; Provisional; Region: PRK02821 1114966004260 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1114966004261 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 1114966004262 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1114966004263 Amidohydrolase; Region: Amidohydro_4; pfam13147 1114966004264 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1114966004265 active site 1114966004266 signal recognition particle protein; Provisional; Region: PRK10867 1114966004267 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1114966004268 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1114966004269 P loop; other site 1114966004270 GTP binding site [chemical binding]; other site 1114966004271 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1114966004272 Predicted esterase [General function prediction only]; Region: COG0627 1114966004273 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 1114966004274 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1114966004275 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1114966004276 P loop; other site 1114966004277 GTP binding site [chemical binding]; other site 1114966004278 Predicted membrane protein [Function unknown]; Region: COG2246 1114966004279 GtrA-like protein; Region: GtrA; pfam04138 1114966004280 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 1114966004281 HicB family; Region: HicB; pfam05534 1114966004282 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1114966004283 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1114966004284 DNA binding site [nucleotide binding] 1114966004285 catalytic residue [active] 1114966004286 H2TH interface [polypeptide binding]; other site 1114966004287 putative catalytic residues [active] 1114966004288 turnover-facilitating residue; other site 1114966004289 intercalation triad [nucleotide binding]; other site 1114966004290 8OG recognition residue [nucleotide binding]; other site 1114966004291 putative reading head residues; other site 1114966004292 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1114966004293 ribonuclease III; Reviewed; Region: rnc; PRK00102 1114966004294 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1114966004295 dimerization interface [polypeptide binding]; other site 1114966004296 active site 1114966004297 metal binding site [ion binding]; metal-binding site 1114966004298 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1114966004299 dsRNA binding site [nucleotide binding]; other site 1114966004300 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 1114966004301 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 1114966004302 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1114966004303 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1114966004304 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1114966004305 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114966004306 dimer interface [polypeptide binding]; other site 1114966004307 conserved gate region; other site 1114966004308 putative PBP binding loops; other site 1114966004309 ABC-ATPase subunit interface; other site 1114966004310 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1114966004311 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114966004312 dimer interface [polypeptide binding]; other site 1114966004313 conserved gate region; other site 1114966004314 putative PBP binding loops; other site 1114966004315 ABC-ATPase subunit interface; other site 1114966004316 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1114966004317 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1114966004318 DNA binding site [nucleotide binding] 1114966004319 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1114966004320 ligand binding site [chemical binding]; other site 1114966004321 dimerization interface [polypeptide binding]; other site 1114966004322 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 1114966004323 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 1114966004324 active site 1114966004325 catalytic site [active] 1114966004326 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; pfam09261 1114966004327 Endo-beta-mannanase [Carbohydrate transport and metabolism]; Region: COG3934 1114966004328 Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565 1114966004329 putative active site [active] 1114966004330 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1114966004331 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114966004332 conserved gate region; other site 1114966004333 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1114966004334 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1114966004335 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1114966004336 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1114966004337 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114966004338 dimer interface [polypeptide binding]; other site 1114966004339 conserved gate region; other site 1114966004340 putative PBP binding loops; other site 1114966004341 ABC-ATPase subunit interface; other site 1114966004342 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1114966004343 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1114966004344 Walker A/P-loop; other site 1114966004345 ATP binding site [chemical binding]; other site 1114966004346 Q-loop/lid; other site 1114966004347 ABC transporter signature motif; other site 1114966004348 Walker B; other site 1114966004349 D-loop; other site 1114966004350 H-loop/switch region; other site 1114966004351 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1114966004352 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1114966004353 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1114966004354 Walker A/P-loop; other site 1114966004355 ATP binding site [chemical binding]; other site 1114966004356 Q-loop/lid; other site 1114966004357 ABC transporter signature motif; other site 1114966004358 Walker B; other site 1114966004359 D-loop; other site 1114966004360 H-loop/switch region; other site 1114966004361 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1114966004362 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1114966004363 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 1114966004364 substrate binding site [chemical binding]; other site 1114966004365 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 1114966004366 GH18 domain of CTS3 (chitinase 3), an uncharacterized protein from the human fungal pathogen Coccidioides posadasii. CTS3 has a chitinase-like glycosyl hydrolase family 18 (GH18) domain; and has homologs in bacteria as well as fungi; Region: GH18_CTS3_chitinase; cd06546 1114966004367 putative active site [active] 1114966004368 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114966004369 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114966004370 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1114966004371 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1114966004372 active site 1114966004373 (T/H)XGH motif; other site 1114966004374 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1114966004375 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114966004376 S-adenosylmethionine binding site [chemical binding]; other site 1114966004377 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 1114966004378 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1114966004379 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1114966004380 ssDNA binding site; other site 1114966004381 generic binding surface II; other site 1114966004382 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1114966004383 ATP binding site [chemical binding]; other site 1114966004384 putative Mg++ binding site [ion binding]; other site 1114966004385 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1114966004386 nucleotide binding region [chemical binding]; other site 1114966004387 ATP-binding site [chemical binding]; other site 1114966004388 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1114966004389 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1114966004390 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1114966004391 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1114966004392 pyruvate dehydrogenase; Provisional; Region: PRK06546 1114966004393 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1114966004394 PYR/PP interface [polypeptide binding]; other site 1114966004395 dimer interface [polypeptide binding]; other site 1114966004396 tetramer interface [polypeptide binding]; other site 1114966004397 TPP binding site [chemical binding]; other site 1114966004398 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1114966004399 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1114966004400 TPP-binding site [chemical binding]; other site 1114966004401 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1114966004402 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1114966004403 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1114966004404 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1114966004405 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 1114966004406 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 1114966004407 oligomer interface [polypeptide binding]; other site 1114966004408 RNA binding site [nucleotide binding]; other site 1114966004409 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1114966004410 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1114966004411 RNase E interface [polypeptide binding]; other site 1114966004412 trimer interface [polypeptide binding]; other site 1114966004413 active site 1114966004414 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1114966004415 putative nucleic acid binding region [nucleotide binding]; other site 1114966004416 G-X-X-G motif; other site 1114966004417 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1114966004418 RNA binding site [nucleotide binding]; other site 1114966004419 domain interface; other site 1114966004420 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1114966004421 16S/18S rRNA binding site [nucleotide binding]; other site 1114966004422 S13e-L30e interaction site [polypeptide binding]; other site 1114966004423 25S rRNA binding site [nucleotide binding]; other site 1114966004424 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1114966004425 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1114966004426 active site 1114966004427 Riboflavin kinase; Region: Flavokinase; smart00904 1114966004428 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1114966004429 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1114966004430 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 1114966004431 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114966004432 dimer interface [polypeptide binding]; other site 1114966004433 conserved gate region; other site 1114966004434 ABC-ATPase subunit interface; other site 1114966004435 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 1114966004436 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114966004437 Walker A/P-loop; other site 1114966004438 ATP binding site [chemical binding]; other site 1114966004439 Q-loop/lid; other site 1114966004440 ABC transporter signature motif; other site 1114966004441 Walker B; other site 1114966004442 D-loop; other site 1114966004443 H-loop/switch region; other site 1114966004444 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1114966004445 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 1114966004446 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1114966004447 RNA binding site [nucleotide binding]; other site 1114966004448 active site 1114966004449 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 1114966004450 Cupin domain; Region: Cupin_2; cl17218 1114966004451 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1114966004452 HTH domain; Region: HTH_11; pfam08279 1114966004453 HTH domain; Region: HTH_11; pfam08279 1114966004454 PRD domain; Region: PRD; pfam00874 1114966004455 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 1114966004456 active site 1114966004457 P-loop; other site 1114966004458 phosphorylation site [posttranslational modification] 1114966004459 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359 1114966004460 active site 1114966004461 phosphorylation site [posttranslational modification] 1114966004462 Glucitol operon activator protein (GutM); Region: GutM; pfam06923 1114966004463 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; pfam03608 1114966004464 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 1114966004465 PTS system, glucitol/sorbitol-specific, IIBC component; Region: EIIBC-GUT; TIGR00825 1114966004466 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 1114966004467 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829 1114966004468 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1114966004469 dimerization domain swap beta strand [polypeptide binding]; other site 1114966004470 regulatory protein interface [polypeptide binding]; other site 1114966004471 active site 1114966004472 regulatory phosphorylation site [posttranslational modification]; other site 1114966004473 Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175 1114966004474 active site 1114966004475 metal binding site [ion binding]; metal-binding site 1114966004476 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1114966004477 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1114966004478 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1114966004479 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 1114966004480 Walker A/P-loop; other site 1114966004481 ATP binding site [chemical binding]; other site 1114966004482 Q-loop/lid; other site 1114966004483 ABC transporter signature motif; other site 1114966004484 Walker B; other site 1114966004485 D-loop; other site 1114966004486 H-loop/switch region; other site 1114966004487 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1114966004488 translation initiation factor IF-2; Region: IF-2; TIGR00487 1114966004489 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1114966004490 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1114966004491 G1 box; other site 1114966004492 putative GEF interaction site [polypeptide binding]; other site 1114966004493 GTP/Mg2+ binding site [chemical binding]; other site 1114966004494 Switch I region; other site 1114966004495 G2 box; other site 1114966004496 G3 box; other site 1114966004497 Switch II region; other site 1114966004498 G4 box; other site 1114966004499 G5 box; other site 1114966004500 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1114966004501 Translation-initiation factor 2; Region: IF-2; pfam11987 1114966004502 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1114966004503 Protein of unknown function (DUF448); Region: DUF448; pfam04296 1114966004504 putative RNA binding cleft [nucleotide binding]; other site 1114966004505 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1114966004506 NusA N-terminal domain; Region: NusA_N; pfam08529 1114966004507 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1114966004508 RNA binding site [nucleotide binding]; other site 1114966004509 homodimer interface [polypeptide binding]; other site 1114966004510 NusA-like KH domain; Region: KH_5; pfam13184 1114966004511 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1114966004512 G-X-X-G motif; other site 1114966004513 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1114966004514 Sm and related proteins; Region: Sm_like; cl00259 1114966004515 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1114966004516 putative oligomer interface [polypeptide binding]; other site 1114966004517 putative RNA binding site [nucleotide binding]; other site 1114966004518 hypothetical protein; Provisional; Region: PRK10621 1114966004519 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1114966004520 metallophosphoesterase, PPA1498 family; Region: P_acnes_RR; TIGR03767 1114966004521 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1114966004522 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1114966004523 dimer interface [polypeptide binding]; other site 1114966004524 motif 1; other site 1114966004525 active site 1114966004526 motif 2; other site 1114966004527 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1114966004528 putative deacylase active site [active] 1114966004529 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1114966004530 active site 1114966004531 motif 3; other site 1114966004532 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1114966004533 anticodon binding site; other site 1114966004534 putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773 1114966004535 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 1114966004536 putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773 1114966004537 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 1114966004538 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 1114966004539 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1114966004540 anchored repeat ABC transporter, substrate-binding protein; Region: anch_rpt_subst; TIGR03772 1114966004541 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 1114966004542 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1114966004543 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 1114966004544 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1114966004545 anchored repeat-type ABC transporter, ATP-binding subunit; Region: anch_rpt_ABC; TIGR03771 1114966004546 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1114966004547 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1114966004548 ABC-ATPase subunit interface; other site 1114966004549 dimer interface [polypeptide binding]; other site 1114966004550 putative PBP binding regions; other site 1114966004551 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 1114966004552 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1114966004553 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1114966004554 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1114966004555 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1114966004556 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 1114966004557 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1114966004558 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 1114966004559 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1114966004560 active site 1114966004561 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1114966004562 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1114966004563 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1114966004564 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1114966004565 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1114966004566 Beta-lactamase; Region: Beta-lactamase; pfam00144 1114966004567 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1114966004568 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1114966004569 potential frameshift: common BLAST hit: gi|295131062|ref|YP_003581725.1| NADP-specific glutamate dehydrogenase 1114966004570 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 1114966004571 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1114966004572 FeS/SAM binding site; other site 1114966004573 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 1114966004574 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1114966004575 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1114966004576 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1114966004577 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1114966004578 hinge region; other site 1114966004579 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1114966004580 putative nucleotide binding site [chemical binding]; other site 1114966004581 uridine monophosphate binding site [chemical binding]; other site 1114966004582 homohexameric interface [polypeptide binding]; other site 1114966004583 elongation factor Ts; Provisional; Region: tsf; PRK09377 1114966004584 UBA/TS-N domain; Region: UBA; pfam00627 1114966004585 Elongation factor TS; Region: EF_TS; pfam00889 1114966004586 Elongation factor TS; Region: EF_TS; pfam00889 1114966004587 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1114966004588 rRNA interaction site [nucleotide binding]; other site 1114966004589 S8 interaction site; other site 1114966004590 putative laminin-1 binding site; other site 1114966004591 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1114966004592 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1114966004593 active site 1114966004594 DNA binding site [nucleotide binding] 1114966004595 Int/Topo IB signature motif; other site 1114966004596 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 1114966004597 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1114966004598 active site 1114966004599 catalytic residues [active] 1114966004600 metal binding site [ion binding]; metal-binding site 1114966004601 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1114966004602 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1114966004603 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1114966004604 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 1114966004605 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1114966004606 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1114966004607 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 1114966004608 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1114966004609 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114966004610 Walker A/P-loop; other site 1114966004611 ATP binding site [chemical binding]; other site 1114966004612 Q-loop/lid; other site 1114966004613 ABC transporter signature motif; other site 1114966004614 Walker B; other site 1114966004615 D-loop; other site 1114966004616 H-loop/switch region; other site 1114966004617 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 1114966004618 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114966004619 NAD(P) binding site [chemical binding]; other site 1114966004620 active site 1114966004621 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114966004622 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1114966004623 NAD(P) binding site [chemical binding]; other site 1114966004624 active site 1114966004625 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 1114966004626 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 1114966004627 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 1114966004628 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114966004629 S-adenosylmethionine binding site [chemical binding]; other site 1114966004630 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1114966004631 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114966004632 Walker A/P-loop; other site 1114966004633 ATP binding site [chemical binding]; other site 1114966004634 Q-loop/lid; other site 1114966004635 ABC transporter signature motif; other site 1114966004636 Walker B; other site 1114966004637 D-loop; other site 1114966004638 H-loop/switch region; other site 1114966004639 ABC transporter; Region: ABC_tran_2; pfam12848 1114966004640 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1114966004641 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114966004642 Coenzyme A binding pocket [chemical binding]; other site 1114966004643 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1114966004644 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1114966004645 phosphate binding site [ion binding]; other site 1114966004646 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1114966004647 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1114966004648 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1114966004649 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1114966004650 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1114966004651 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1114966004652 trimerization site [polypeptide binding]; other site 1114966004653 active site 1114966004654 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1114966004655 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1114966004656 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1114966004657 catalytic residue [active] 1114966004658 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1114966004659 FeS assembly ATPase SufC; Region: sufC; TIGR01978 1114966004660 Walker A/P-loop; other site 1114966004661 ATP binding site [chemical binding]; other site 1114966004662 Q-loop/lid; other site 1114966004663 ABC transporter signature motif; other site 1114966004664 Walker B; other site 1114966004665 D-loop; other site 1114966004666 H-loop/switch region; other site 1114966004667 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 1114966004668 [2Fe-2S] cluster binding site [ion binding]; other site 1114966004669 FeS assembly protein SufD; Region: sufD; TIGR01981 1114966004670 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 1114966004671 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1114966004672 FeS assembly protein SufB; Region: sufB; TIGR01980 1114966004673 Predicted transcriptional regulator [Transcription]; Region: COG2345 1114966004674 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1114966004675 dimerization interface [polypeptide binding]; other site 1114966004676 putative DNA binding site [nucleotide binding]; other site 1114966004677 putative Zn2+ binding site [ion binding]; other site 1114966004678 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 1114966004679 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1114966004680 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114966004681 dimer interface [polypeptide binding]; other site 1114966004682 conserved gate region; other site 1114966004683 putative PBP binding loops; other site 1114966004684 ABC-ATPase subunit interface; other site 1114966004685 potential frameshift: common BLAST hit: gi|295131103|ref|YP_003581766.1| putative type IV conjugative transfer system protein TraL 1114966004686 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1114966004687 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1114966004688 DNA binding site [nucleotide binding] 1114966004689 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_10; cd06292 1114966004690 putative dimerization interface [polypeptide binding]; other site 1114966004691 putative ligand binding site [chemical binding]; other site 1114966004692 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 1114966004693 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 1114966004694 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1114966004695 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1114966004696 Walker A/P-loop; other site 1114966004697 ATP binding site [chemical binding]; other site 1114966004698 Q-loop/lid; other site 1114966004699 ABC transporter signature motif; other site 1114966004700 Walker B; other site 1114966004701 D-loop; other site 1114966004702 H-loop/switch region; other site 1114966004703 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1114966004704 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1114966004705 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1114966004706 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1114966004707 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 1114966004708 catalytic site [active] 1114966004709 BNR repeat-like domain; Region: BNR_2; pfam13088 1114966004710 Asp-box motif; other site 1114966004711 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1114966004712 UbiA prenyltransferase family; Region: UbiA; pfam01040 1114966004713 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1114966004714 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1114966004715 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1114966004716 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 1114966004717 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 1114966004718 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1114966004719 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 1114966004720 putative active site [active] 1114966004721 Predicted membrane protein [Function unknown]; Region: COG2259 1114966004722 Thioredoxin; Region: Thioredoxin_4; cl17273 1114966004723 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1114966004724 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208 1114966004725 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1114966004726 active site 1114966004727 HIGH motif; other site 1114966004728 nucleotide binding site [chemical binding]; other site 1114966004729 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1114966004730 active site 1114966004731 KMSKS motif; other site 1114966004732 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1114966004733 tRNA binding surface [nucleotide binding]; other site 1114966004734 anticodon binding site; other site 1114966004735 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1114966004736 Endo-alpha-N-acetylgalactosaminidase; Region: Glyco_hydro_101; pfam12905 1114966004737 Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown]; Region: COG4946 1114966004738 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1114966004739 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1114966004740 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 1114966004741 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1114966004742 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1114966004743 protein binding site [polypeptide binding]; other site 1114966004744 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 1114966004745 Domain interface; other site 1114966004746 Peptide binding site; other site 1114966004747 Active site tetrad [active] 1114966004748 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1114966004749 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1114966004750 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114966004751 Walker A motif; other site 1114966004752 ATP binding site [chemical binding]; other site 1114966004753 Walker B motif; other site 1114966004754 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1114966004755 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 1114966004756 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1114966004757 oligomer interface [polypeptide binding]; other site 1114966004758 active site residues [active] 1114966004759 Clp protease; Region: CLP_protease; pfam00574 1114966004760 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1114966004761 oligomer interface [polypeptide binding]; other site 1114966004762 active site residues [active] 1114966004763 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1114966004764 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1114966004765 trigger factor; Provisional; Region: tig; PRK01490 1114966004766 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1114966004767 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1114966004768 potential protein location (hypothetical protein TIA2EST2_07810 [Propionibacterium acnes TypeIA2 P.acn33]) that overlaps RNA (tRNA-G) 1114966004769 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 1114966004770 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1114966004771 ATP binding site [chemical binding]; other site 1114966004772 putative Mg++ binding site [ion binding]; other site 1114966004773 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 1114966004774 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1114966004775 nucleotide binding region [chemical binding]; other site 1114966004776 ATP-binding site [chemical binding]; other site 1114966004777 potential frameshift: common BLAST hit: gi|50843083|ref|YP_056310.1| DeaD/DeaH box helicase 1114966004778 Part of AAA domain; Region: AAA_19; pfam13245 1114966004779 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1114966004780 Family description; Region: UvrD_C_2; pfam13538 1114966004781 The HIRAN protein (HIP116, Rad5p N-terminal) is found in the N-terminal regions of the SWI2/SNF2 proteins typified by HIP116 and Rad5p; Region: HIRAN; smart00910 1114966004782 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1114966004783 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 1114966004784 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1114966004785 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1114966004786 dimer interface [polypeptide binding]; other site 1114966004787 putative anticodon binding site; other site 1114966004788 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1114966004789 motif 1; other site 1114966004790 dimer interface [polypeptide binding]; other site 1114966004791 active site 1114966004792 motif 2; other site 1114966004793 motif 3; other site 1114966004794 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1114966004795 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 1114966004796 putative DNA binding site [nucleotide binding]; other site 1114966004797 catalytic residue [active] 1114966004798 putative H2TH interface [polypeptide binding]; other site 1114966004799 putative catalytic residues [active] 1114966004800 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1114966004801 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1114966004802 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 1114966004803 hypothetical protein; Provisional; Region: PRK01346 1114966004804 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1114966004805 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1114966004806 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1114966004807 nucleotide binding pocket [chemical binding]; other site 1114966004808 K-X-D-G motif; other site 1114966004809 catalytic site [active] 1114966004810 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1114966004811 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1114966004812 Helix-hairpin-helix motif; Region: HHH; pfam00633 1114966004813 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1114966004814 Dimer interface [polypeptide binding]; other site 1114966004815 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 1114966004816 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 1114966004817 Zn binding site [ion binding]; other site 1114966004818 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1114966004819 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1114966004820 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1114966004821 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1114966004822 active site 1114966004823 catalytic site [active] 1114966004824 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1114966004825 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1114966004826 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1114966004827 active site 1114966004828 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1114966004829 active site 1114966004830 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1114966004831 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1114966004832 acyl-activating enzyme (AAE) consensus motif; other site 1114966004833 putative AMP binding site [chemical binding]; other site 1114966004834 putative active site [active] 1114966004835 putative CoA binding site [chemical binding]; other site 1114966004836 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1114966004837 MarR family; Region: MarR_2; pfam12802 1114966004838 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1114966004839 FAD binding domain; Region: FAD_binding_4; pfam01565 1114966004840 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1114966004841 Predicted transcriptional regulators [Transcription]; Region: COG1695 1114966004842 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1114966004843 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1114966004844 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114966004845 Walker A/P-loop; other site 1114966004846 ATP binding site [chemical binding]; other site 1114966004847 Q-loop/lid; other site 1114966004848 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1114966004849 ABC transporter; Region: ABC_tran_2; pfam12848 1114966004850 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1114966004851 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1114966004852 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1114966004853 dimer interface [polypeptide binding]; other site 1114966004854 ssDNA binding site [nucleotide binding]; other site 1114966004855 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1114966004856 YfjP GTPase; Region: YfjP; cd11383 1114966004857 G1 box; other site 1114966004858 GTP/Mg2+ binding site [chemical binding]; other site 1114966004859 Switch I region; other site 1114966004860 G2 box; other site 1114966004861 Switch II region; other site 1114966004862 G3 box; other site 1114966004863 G4 box; other site 1114966004864 G5 box; other site 1114966004865 Dynamin family; Region: Dynamin_N; pfam00350 1114966004866 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1114966004867 G1 box; other site 1114966004868 GTP/Mg2+ binding site [chemical binding]; other site 1114966004869 G2 box; other site 1114966004870 Switch I region; other site 1114966004871 Protease prsW family; Region: PrsW-protease; pfam13367 1114966004872 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114966004873 putative substrate translocation pore; other site 1114966004874 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114966004875 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1114966004876 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1114966004877 catalytic site [active] 1114966004878 putative active site [active] 1114966004879 putative substrate binding site [chemical binding]; other site 1114966004880 dimer interface [polypeptide binding]; other site 1114966004881 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1114966004882 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1114966004883 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1114966004884 active site 1114966004885 ATP binding site [chemical binding]; other site 1114966004886 substrate binding site [chemical binding]; other site 1114966004887 activation loop (A-loop); other site 1114966004888 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1114966004889 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1114966004890 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 1114966004891 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1114966004892 active site 1114966004893 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1114966004894 generic binding surface I; other site 1114966004895 generic binding surface II; other site 1114966004896 DNA Polymerase Y-family; Region: PolY_like; cd03468 1114966004897 active site 1114966004898 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 1114966004899 DNA binding site [nucleotide binding] 1114966004900 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 1114966004901 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 1114966004902 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1114966004903 catalytic triad [active] 1114966004904 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1114966004905 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1114966004906 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114966004907 dimer interface [polypeptide binding]; other site 1114966004908 conserved gate region; other site 1114966004909 putative PBP binding loops; other site 1114966004910 ABC-ATPase subunit interface; other site 1114966004911 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1114966004912 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114966004913 dimer interface [polypeptide binding]; other site 1114966004914 conserved gate region; other site 1114966004915 putative PBP binding loops; other site 1114966004916 ABC-ATPase subunit interface; other site 1114966004917 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 1114966004918 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1114966004919 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1114966004920 catalytic triad [active] 1114966004921 CH-type (Chalaropsis-type) lysozymes represent one of four functionally-defined classes of peptidoglycan hydrolases (also referred to as endo-N-acetylmuramidases) that cleave bacterial cell wall peptidoglycans. CH-type lysozymes exhibit both lysozyme; Region: GH25_CH-type; cd06412 1114966004922 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1114966004923 active site 1114966004924 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 1114966004925 active site 1114966004926 catalytic triad [active] 1114966004927 oxyanion hole [active] 1114966004928 Thrombospondin type 3 repeat; Region: TSP_3; pfam02412 1114966004929 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 1114966004930 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1114966004931 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1114966004932 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1114966004933 putative active site [active] 1114966004934 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1114966004935 DNA polymerase IV; Provisional; Region: PRK03348 1114966004936 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1114966004937 active site 1114966004938 DNA binding site [nucleotide binding] 1114966004939 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1114966004940 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1114966004941 folate binding site [chemical binding]; other site 1114966004942 NADP+ binding site [chemical binding]; other site 1114966004943 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1114966004944 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1114966004945 dimerization interface [polypeptide binding]; other site 1114966004946 active site 1114966004947 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1114966004948 active site 1114966004949 dimerization interface [polypeptide binding]; other site 1114966004950 ribonuclease PH; Reviewed; Region: rph; PRK00173 1114966004951 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1114966004952 hexamer interface [polypeptide binding]; other site 1114966004953 active site 1114966004954 glutamate racemase; Provisional; Region: PRK00865 1114966004955 FeoA domain; Region: FeoA; pfam04023 1114966004956 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 1114966004957 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1114966004958 G1 box; other site 1114966004959 GTP/Mg2+ binding site [chemical binding]; other site 1114966004960 Switch I region; other site 1114966004961 G2 box; other site 1114966004962 G3 box; other site 1114966004963 Switch II region; other site 1114966004964 G4 box; other site 1114966004965 G5 box; other site 1114966004966 Nucleoside recognition; Region: Gate; pfam07670 1114966004967 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1114966004968 Nucleoside recognition; Region: Gate; pfam07670 1114966004969 NifU-like domain; Region: NifU; cl00484 1114966004970 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 1114966004971 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 1114966004972 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1114966004973 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1114966004974 active site 1114966004975 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1114966004976 IHF dimer interface [polypeptide binding]; other site 1114966004977 IHF - DNA interface [nucleotide binding]; other site 1114966004978 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 1114966004979 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 1114966004980 RDD family; Region: RDD; pfam06271 1114966004981 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 1114966004982 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1114966004983 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1114966004984 trimer interface [polypeptide binding]; other site 1114966004985 active site 1114966004986 dimer interface [polypeptide binding]; other site 1114966004987 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1114966004988 Cation efflux family; Region: Cation_efflux; pfam01545 1114966004989 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1114966004990 Trm112p-like protein; Region: Trm112p; cl01066 1114966004991 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 1114966004992 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 1114966004993 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1114966004994 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1114966004995 active site 1114966004996 Transcription factor WhiB; Region: Whib; pfam02467 1114966004997 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1114966004998 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 1114966004999 Substrate binding site; other site 1114966005000 TIGR03089 family protein; Region: TIGR03089 1114966005001 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1114966005002 ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525 1114966005003 Ligand binding site; other site 1114966005004 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 1114966005005 potential frameshift: common BLAST hit: gi|50843162|ref|YP_056389.1| beta-galactosidase 1114966005006 AIR carboxylase; Region: AIRC; pfam00731 1114966005007 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1114966005008 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1114966005009 NAD binding site [chemical binding]; other site 1114966005010 ATP-grasp domain; Region: ATP-grasp; pfam02222 1114966005011 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 1114966005012 active site pocket [active] 1114966005013 oxyanion hole [active] 1114966005014 catalytic triad [active] 1114966005015 active site nucleophile [active] 1114966005016 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1114966005017 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1114966005018 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1114966005019 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1114966005020 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1114966005021 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 1114966005022 Maf-like protein; Region: Maf; pfam02545 1114966005023 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1114966005024 active site 1114966005025 dimer interface [polypeptide binding]; other site 1114966005026 short chain dehydrogenase; Provisional; Region: PRK08219 1114966005027 classical (c) SDRs; Region: SDR_c; cd05233 1114966005028 NAD(P) binding site [chemical binding]; other site 1114966005029 active site 1114966005030 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1114966005031 dimer interface [polypeptide binding]; other site 1114966005032 substrate binding site [chemical binding]; other site 1114966005033 ATP binding site [chemical binding]; other site 1114966005034 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1114966005035 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1114966005036 Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158 1114966005037 TQXA domain; Region: TQXA_dom; TIGR03934 1114966005038 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 1114966005039 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 1114966005040 oligomer interface [polypeptide binding]; other site 1114966005041 metal binding site [ion binding]; metal-binding site 1114966005042 metal binding site [ion binding]; metal-binding site 1114966005043 putative Cl binding site [ion binding]; other site 1114966005044 aspartate ring; other site 1114966005045 basic sphincter; other site 1114966005046 hydrophobic gate; other site 1114966005047 periplasmic entrance; other site 1114966005048 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1114966005049 nudix motif; other site 1114966005050 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1114966005051 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1114966005052 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1114966005053 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1114966005054 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1114966005055 carboxyltransferase (CT) interaction site; other site 1114966005056 biotinylation site [posttranslational modification]; other site 1114966005057 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 1114966005058 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1114966005059 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1114966005060 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1114966005061 purine nucleoside phosphorylase; Provisional; Region: PRK08202 1114966005062 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 1114966005063 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1114966005064 active site 1114966005065 substrate binding site [chemical binding]; other site 1114966005066 metal binding site [ion binding]; metal-binding site 1114966005067 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1114966005068 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1114966005069 acyl-activating enzyme (AAE) consensus motif; other site 1114966005070 AMP binding site [chemical binding]; other site 1114966005071 active site 1114966005072 CoA binding site [chemical binding]; other site 1114966005073 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1114966005074 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114966005075 putative substrate translocation pore; other site 1114966005076 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 1114966005077 active site 1114966005078 catalytic site [active] 1114966005079 substrate binding site [chemical binding]; other site 1114966005080 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 1114966005081 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1114966005082 active site 1114966005083 HIGH motif; other site 1114966005084 KMSKS motif; other site 1114966005085 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1114966005086 tRNA binding surface [nucleotide binding]; other site 1114966005087 anticodon binding site; other site 1114966005088 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1114966005089 RNA/DNA hybrid binding site [nucleotide binding]; other site 1114966005090 active site 1114966005091 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1114966005092 active site 1114966005093 catalytic motif [active] 1114966005094 Zn binding site [ion binding]; other site 1114966005095 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1114966005096 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1114966005097 TM-ABC transporter signature motif; other site 1114966005098 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1114966005099 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1114966005100 TM-ABC transporter signature motif; other site 1114966005101 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1114966005102 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1114966005103 Walker A/P-loop; other site 1114966005104 ATP binding site [chemical binding]; other site 1114966005105 Q-loop/lid; other site 1114966005106 ABC transporter signature motif; other site 1114966005107 Walker B; other site 1114966005108 D-loop; other site 1114966005109 H-loop/switch region; other site 1114966005110 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1114966005111 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1114966005112 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 1114966005113 ligand binding site [chemical binding]; other site 1114966005114 Phosphotransferase enzyme family; Region: APH; pfam01636 1114966005115 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1114966005116 Domain of unknown function DUF21; Region: DUF21; pfam01595 1114966005117 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1114966005118 Transporter associated domain; Region: CorC_HlyC; smart01091 1114966005119 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 1114966005120 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 1114966005121 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1114966005122 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1114966005123 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 1114966005124 active site 1114966005125 substrate binding site [chemical binding]; other site 1114966005126 cosubstrate binding site; other site 1114966005127 catalytic site [active] 1114966005128 malate dehydrogenase; Provisional; Region: PRK05442 1114966005129 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 1114966005130 NAD(P) binding site [chemical binding]; other site 1114966005131 dimer interface [polypeptide binding]; other site 1114966005132 malate binding site [chemical binding]; other site 1114966005133 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 1114966005134 putative catalytic cysteine [active] 1114966005135 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 1114966005136 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 1114966005137 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1114966005138 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1114966005139 homodimer interface [polypeptide binding]; other site 1114966005140 NADP binding site [chemical binding]; other site 1114966005141 substrate binding site [chemical binding]; other site 1114966005142 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1114966005143 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1114966005144 catalytic residue [active] 1114966005145 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1114966005146 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1114966005147 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1114966005148 purine monophosphate binding site [chemical binding]; other site 1114966005149 dimer interface [polypeptide binding]; other site 1114966005150 putative catalytic residues [active] 1114966005151 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1114966005152 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1114966005153 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1114966005154 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1114966005155 active site 1114966005156 cosubstrate binding site; other site 1114966005157 substrate binding site [chemical binding]; other site 1114966005158 catalytic site [active] 1114966005159 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1114966005160 homopentamer interface [polypeptide binding]; other site 1114966005161 active site 1114966005162 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1114966005163 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1114966005164 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1114966005165 dimerization interface [polypeptide binding]; other site 1114966005166 active site 1114966005167 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1114966005168 Lumazine binding domain; Region: Lum_binding; pfam00677 1114966005169 Lumazine binding domain; Region: Lum_binding; pfam00677 1114966005170 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1114966005171 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1114966005172 catalytic motif [active] 1114966005173 Zn binding site [ion binding]; other site 1114966005174 RibD C-terminal domain; Region: RibD_C; cl17279 1114966005175 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1114966005176 CoA binding domain; Region: CoA_binding; smart00881 1114966005177 CoA-ligase; Region: Ligase_CoA; pfam00549 1114966005178 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1114966005179 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1114966005180 CoA-ligase; Region: Ligase_CoA; pfam00549 1114966005181 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1114966005182 Part of AAA domain; Region: AAA_19; pfam13245 1114966005183 Family description; Region: UvrD_C_2; pfam13538 1114966005184 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1114966005185 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 1114966005186 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1114966005187 Walker A/P-loop; other site 1114966005188 ATP binding site [chemical binding]; other site 1114966005189 Q-loop/lid; other site 1114966005190 ABC transporter signature motif; other site 1114966005191 Walker B; other site 1114966005192 D-loop; other site 1114966005193 H-loop/switch region; other site 1114966005194 NIL domain; Region: NIL; pfam09383 1114966005195 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114966005196 ABC-ATPase subunit interface; other site 1114966005197 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1114966005198 PLD-like domain; Region: PLDc_2; pfam13091 1114966005199 putative active site [active] 1114966005200 catalytic site [active] 1114966005201 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1114966005202 PLD-like domain; Region: PLDc_2; pfam13091 1114966005203 putative active site [active] 1114966005204 catalytic site [active] 1114966005205 PspC domain; Region: PspC; pfam04024 1114966005206 GMP synthase; Reviewed; Region: guaA; PRK00074 1114966005207 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1114966005208 AMP/PPi binding site [chemical binding]; other site 1114966005209 candidate oxyanion hole; other site 1114966005210 catalytic triad [active] 1114966005211 potential glutamine specificity residues [chemical binding]; other site 1114966005212 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1114966005213 ATP Binding subdomain [chemical binding]; other site 1114966005214 Ligand Binding sites [chemical binding]; other site 1114966005215 Dimerization subdomain; other site 1114966005216 serine O-acetyltransferase; Region: cysE; TIGR01172 1114966005217 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1114966005218 trimer interface [polypeptide binding]; other site 1114966005219 active site 1114966005220 substrate binding site [chemical binding]; other site 1114966005221 CoA binding site [chemical binding]; other site 1114966005222 chorismate mutase; Provisional; Region: PRK09239 1114966005223 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 1114966005224 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1114966005225 phosphate binding site [ion binding]; other site 1114966005226 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1114966005227 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1114966005228 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1114966005229 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1114966005230 active site 1114966005231 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 1114966005232 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 1114966005233 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1114966005234 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1114966005235 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1114966005236 ring oligomerisation interface [polypeptide binding]; other site 1114966005237 ATP/Mg binding site [chemical binding]; other site 1114966005238 stacking interactions; other site 1114966005239 hinge regions; other site 1114966005240 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1114966005241 oligomerisation interface [polypeptide binding]; other site 1114966005242 mobile loop; other site 1114966005243 roof hairpin; other site 1114966005244 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1114966005245 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1114966005246 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1114966005247 Walker A/P-loop; other site 1114966005248 ATP binding site [chemical binding]; other site 1114966005249 Q-loop/lid; other site 1114966005250 ABC transporter signature motif; other site 1114966005251 Walker B; other site 1114966005252 D-loop; other site 1114966005253 H-loop/switch region; other site 1114966005254 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1114966005255 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1114966005256 ABC-ATPase subunit interface; other site 1114966005257 dimer interface [polypeptide binding]; other site 1114966005258 putative PBP binding regions; other site 1114966005259 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 1114966005260 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1114966005261 intersubunit interface [polypeptide binding]; other site 1114966005262 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 1114966005263 putative active site [active] 1114966005264 nucleotide binding site [chemical binding]; other site 1114966005265 nudix motif; other site 1114966005266 putative metal binding site [ion binding]; other site 1114966005267 UGMP family protein; Validated; Region: PRK09604 1114966005268 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 1114966005269 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1114966005270 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114966005271 Coenzyme A binding pocket [chemical binding]; other site 1114966005272 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1114966005273 Glycoprotease family; Region: Peptidase_M22; pfam00814 1114966005274 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1114966005275 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1114966005276 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1114966005277 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1114966005278 ATP binding site [chemical binding]; other site 1114966005279 Mg++ binding site [ion binding]; other site 1114966005280 motif III; other site 1114966005281 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1114966005282 nucleotide binding region [chemical binding]; other site 1114966005283 ATP-binding site [chemical binding]; other site 1114966005284 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1114966005285 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1114966005286 Walker A/P-loop; other site 1114966005287 ATP binding site [chemical binding]; other site 1114966005288 Q-loop/lid; other site 1114966005289 ABC transporter signature motif; other site 1114966005290 Walker B; other site 1114966005291 D-loop; other site 1114966005292 H-loop/switch region; other site 1114966005293 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1114966005294 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1114966005295 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 1114966005296 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1114966005297 putative substrate binding site [chemical binding]; other site 1114966005298 putative ATP binding site [chemical binding]; other site 1114966005299 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1114966005300 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1114966005301 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1114966005302 glutaminase active site [active] 1114966005303 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1114966005304 dimer interface [polypeptide binding]; other site 1114966005305 active site 1114966005306 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1114966005307 dimer interface [polypeptide binding]; other site 1114966005308 active site 1114966005309 Lipase (class 2); Region: Lipase_2; pfam01674 1114966005310 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1114966005311 Lipase (class 2); Region: Lipase_2; pfam01674 1114966005312 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1114966005313 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1114966005314 pantothenate kinase; Provisional; Region: PRK05439 1114966005315 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1114966005316 ATP-binding site [chemical binding]; other site 1114966005317 CoA-binding site [chemical binding]; other site 1114966005318 Mg2+-binding site [ion binding]; other site 1114966005319 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 1114966005320 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1114966005321 active site 1114966005322 substrate binding site [chemical binding]; other site 1114966005323 metal binding site [ion binding]; metal-binding site 1114966005324 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1114966005325 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1114966005326 23S rRNA interface [nucleotide binding]; other site 1114966005327 L3 interface [polypeptide binding]; other site 1114966005328 Endo-beta-N-acetylglucosaminidase D [Carbohydrate transport and metabolism]; Region: COG4724 1114966005329 Glycosyl hydrolase family 85; Region: Glyco_hydro_85; pfam03644 1114966005330 active site 1114966005331 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114966005332 S-adenosylmethionine binding site [chemical binding]; other site 1114966005333 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1114966005334 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1114966005335 dimerization interface 3.5A [polypeptide binding]; other site 1114966005336 active site 1114966005337 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114966005338 S-adenosylmethionine binding site [chemical binding]; other site 1114966005339 Cobalt transport protein; Region: CbiQ; cl00463 1114966005340 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1114966005341 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1114966005342 Walker A/P-loop; other site 1114966005343 ATP binding site [chemical binding]; other site 1114966005344 Q-loop/lid; other site 1114966005345 ABC transporter signature motif; other site 1114966005346 Walker B; other site 1114966005347 D-loop; other site 1114966005348 H-loop/switch region; other site 1114966005349 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1114966005350 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114966005351 Walker A/P-loop; other site 1114966005352 ATP binding site [chemical binding]; other site 1114966005353 Q-loop/lid; other site 1114966005354 ABC transporter signature motif; other site 1114966005355 Walker B; other site 1114966005356 D-loop; other site 1114966005357 H-loop/switch region; other site 1114966005358 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 1114966005359 classical (c) SDRs; Region: SDR_c; cd05233 1114966005360 NAD(P) binding site [chemical binding]; other site 1114966005361 active site 1114966005362 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 1114966005363 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1114966005364 Walker A/P-loop; other site 1114966005365 ATP binding site [chemical binding]; other site 1114966005366 Q-loop/lid; other site 1114966005367 ABC transporter signature motif; other site 1114966005368 Walker B; other site 1114966005369 D-loop; other site 1114966005370 H-loop/switch region; other site 1114966005371 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1114966005372 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1114966005373 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1114966005374 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 1114966005375 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 1114966005376 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 1114966005377 Beta-galactosidase, domain 2; Region: BetaGal_dom2; smart01029 1114966005378 Beta-galactosidase, domain 2; Region: BetaGal_dom2; pfam10435 1114966005379 Beta-galactosidase jelly roll domain; Region: BetaGal_dom4_5; pfam13364 1114966005380 Beta-galactosidase jelly roll domain; Region: BetaGal_dom4_5; pfam13364 1114966005381 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 1114966005382 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 1114966005383 active site 1114966005384 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1114966005385 sugar binding site [chemical binding]; other site 1114966005386 potential frameshift: common BLAST hit: gi|295131348|ref|YP_003582011.1| transporter, major facilitator family protein 1114966005387 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1114966005388 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1114966005389 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1114966005390 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1114966005391 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1114966005392 alphaNTD homodimer interface [polypeptide binding]; other site 1114966005393 alphaNTD - beta interaction site [polypeptide binding]; other site 1114966005394 alphaNTD - beta' interaction site [polypeptide binding]; other site 1114966005395 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1114966005396 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1114966005397 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1114966005398 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1114966005399 RNA binding surface [nucleotide binding]; other site 1114966005400 30S ribosomal protein S11; Validated; Region: PRK05309 1114966005401 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1114966005402 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1114966005403 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 1114966005404 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1114966005405 rRNA binding site [nucleotide binding]; other site 1114966005406 predicted 30S ribosome binding site; other site 1114966005407 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1114966005408 active site 1114966005409 adenylate kinase; Reviewed; Region: adk; PRK00279 1114966005410 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1114966005411 AMP-binding site [chemical binding]; other site 1114966005412 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1114966005413 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1114966005414 SecY translocase; Region: SecY; pfam00344 1114966005415 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114966005416 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114966005417 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 1114966005418 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 1114966005419 putative active site [active] 1114966005420 putative metal binding site [ion binding]; other site 1114966005421 catalytic site [active] 1114966005422 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1114966005423 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 1114966005424 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1114966005425 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1114966005426 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1114966005427 23S rRNA binding site [nucleotide binding]; other site 1114966005428 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1114966005429 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1114966005430 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1114966005431 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1114966005432 23S rRNA interface [nucleotide binding]; other site 1114966005433 5S rRNA interface [nucleotide binding]; other site 1114966005434 L27 interface [polypeptide binding]; other site 1114966005435 L5 interface [polypeptide binding]; other site 1114966005436 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1114966005437 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1114966005438 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1114966005439 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1114966005440 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 1114966005441 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1114966005442 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1114966005443 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1114966005444 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1114966005445 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1114966005446 RNA binding site [nucleotide binding]; other site 1114966005447 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1114966005448 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1114966005449 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1114966005450 23S rRNA interface [nucleotide binding]; other site 1114966005451 putative translocon interaction site; other site 1114966005452 signal recognition particle (SRP54) interaction site; other site 1114966005453 L23 interface [polypeptide binding]; other site 1114966005454 trigger factor interaction site; other site 1114966005455 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1114966005456 23S rRNA interface [nucleotide binding]; other site 1114966005457 5S rRNA interface [nucleotide binding]; other site 1114966005458 putative antibiotic binding site [chemical binding]; other site 1114966005459 L25 interface [polypeptide binding]; other site 1114966005460 L27 interface [polypeptide binding]; other site 1114966005461 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1114966005462 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1114966005463 G-X-X-G motif; other site 1114966005464 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1114966005465 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1114966005466 putative translocon binding site; other site 1114966005467 protein-rRNA interface [nucleotide binding]; other site 1114966005468 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1114966005469 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1114966005470 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1114966005471 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1114966005472 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1114966005473 50S ribosomal protein L4; Provisional; Region: rplD; PRK14547 1114966005474 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1114966005475 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1114966005476 6-carboxyhexanoate--CoA ligase; Region: BioW; pfam03744 1114966005477 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 1114966005478 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1114966005479 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1114966005480 catalytic residue [active] 1114966005481 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1114966005482 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1114966005483 HIGH motif; other site 1114966005484 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1114966005485 active site 1114966005486 KMSKS motif; other site 1114966005487 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 1114966005488 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1114966005489 active site 1114966005490 HIGH motif; other site 1114966005491 nucleotide binding site [chemical binding]; other site 1114966005492 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1114966005493 active site 1114966005494 KMSKS motif; other site 1114966005495 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 1114966005496 potential frameshift: common BLAST hit: gi|50843325|ref|YP_056552.1| 2',3'-cyclic-nucleotide 2'-phosphodiesterase 1114966005497 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 1114966005498 elongation factor Tu; Reviewed; Region: PRK00049 1114966005499 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1114966005500 G1 box; other site 1114966005501 GEF interaction site [polypeptide binding]; other site 1114966005502 GTP/Mg2+ binding site [chemical binding]; other site 1114966005503 Switch I region; other site 1114966005504 G2 box; other site 1114966005505 G3 box; other site 1114966005506 Switch II region; other site 1114966005507 G4 box; other site 1114966005508 G5 box; other site 1114966005509 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1114966005510 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1114966005511 Antibiotic Binding Site [chemical binding]; other site 1114966005512 elongation factor G; Reviewed; Region: PRK00007 1114966005513 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1114966005514 G1 box; other site 1114966005515 putative GEF interaction site [polypeptide binding]; other site 1114966005516 GTP/Mg2+ binding site [chemical binding]; other site 1114966005517 Switch I region; other site 1114966005518 G2 box; other site 1114966005519 G3 box; other site 1114966005520 Switch II region; other site 1114966005521 G4 box; other site 1114966005522 G5 box; other site 1114966005523 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1114966005524 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1114966005525 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1114966005526 30S ribosomal protein S7; Validated; Region: PRK05302 1114966005527 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1114966005528 S17 interaction site [polypeptide binding]; other site 1114966005529 S8 interaction site; other site 1114966005530 16S rRNA interaction site [nucleotide binding]; other site 1114966005531 streptomycin interaction site [chemical binding]; other site 1114966005532 23S rRNA interaction site [nucleotide binding]; other site 1114966005533 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1114966005534 Filamin/ABP280 repeat; Region: Filamin; pfam00630 1114966005535 putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773 1114966005536 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 1114966005537 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 1114966005538 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1114966005539 DNA-directed RNA polymerase, beta' subunit, predominant form; Region: rpoC_TIGR; TIGR02386 1114966005540 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1114966005541 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1114966005542 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1114966005543 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1114966005544 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 1114966005545 G-loop; other site 1114966005546 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1114966005547 DNA binding site [nucleotide binding] 1114966005548 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1114966005549 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1114966005550 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1114966005551 RPB12 interaction site [polypeptide binding]; other site 1114966005552 RPB1 interaction site [polypeptide binding]; other site 1114966005553 RPB10 interaction site [polypeptide binding]; other site 1114966005554 RPB11 interaction site [polypeptide binding]; other site 1114966005555 RPB3 interaction site [polypeptide binding]; other site 1114966005556 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1114966005557 core dimer interface [polypeptide binding]; other site 1114966005558 peripheral dimer interface [polypeptide binding]; other site 1114966005559 L10 interface [polypeptide binding]; other site 1114966005560 L11 interface [polypeptide binding]; other site 1114966005561 putative EF-Tu interaction site [polypeptide binding]; other site 1114966005562 putative EF-G interaction site [polypeptide binding]; other site 1114966005563 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1114966005564 23S rRNA interface [nucleotide binding]; other site 1114966005565 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1114966005566 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1114966005567 mRNA/rRNA interface [nucleotide binding]; other site 1114966005568 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1114966005569 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1114966005570 23S rRNA interface [nucleotide binding]; other site 1114966005571 putative thiostrepton binding site; other site 1114966005572 L7/L12 interface [polypeptide binding]; other site 1114966005573 L25 interface [polypeptide binding]; other site 1114966005574 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1114966005575 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1114966005576 putative homodimer interface [polypeptide binding]; other site 1114966005577 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1114966005578 heterodimer interface [polypeptide binding]; other site 1114966005579 homodimer interface [polypeptide binding]; other site 1114966005580 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 1114966005581 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 1114966005582 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1114966005583 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114966005584 homodimer interface [polypeptide binding]; other site 1114966005585 catalytic residue [active] 1114966005586 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 1114966005587 FAD binding domain; Region: FAD_binding_4; pfam01565 1114966005588 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1114966005589 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 1114966005590 active site 1114966005591 catalytic site [active] 1114966005592 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1114966005593 active site 1114966005594 catalytic site [active] 1114966005595 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 1114966005596 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 1114966005597 putative active site [active] 1114966005598 putative catalytic site [active] 1114966005599 putative DNA binding site [nucleotide binding]; other site 1114966005600 putative phosphate binding site [ion binding]; other site 1114966005601 metal binding site A [ion binding]; metal-binding site 1114966005602 putative AP binding site [nucleotide binding]; other site 1114966005603 putative metal binding site B [ion binding]; other site 1114966005604 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1114966005605 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 1114966005606 substrate binding site [chemical binding]; other site 1114966005607 oxyanion hole (OAH) forming residues; other site 1114966005608 trimer interface [polypeptide binding]; other site 1114966005609 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 1114966005610 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 1114966005611 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 1114966005612 4Fe-4S binding domain; Region: Fer4; cl02805 1114966005613 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329 1114966005614 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194 1114966005615 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 1114966005616 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1114966005617 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1114966005618 dimer interface [polypeptide binding]; other site 1114966005619 PYR/PP interface [polypeptide binding]; other site 1114966005620 TPP binding site [chemical binding]; other site 1114966005621 substrate binding site [chemical binding]; other site 1114966005622 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 1114966005623 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 1114966005624 TPP-binding site [chemical binding]; other site 1114966005625 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 1114966005626 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 1114966005627 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 1114966005628 active site 1114966005629 catalytic triad [active] 1114966005630 oxyanion hole [active] 1114966005631 Thrombospondin type 3 repeat; Region: TSP_3; pfam02412 1114966005632 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 1114966005633 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 1114966005634 active site 1114966005635 Zn binding site [ion binding]; other site 1114966005636 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114966005637 heme ABC exporter, ATP-binding protein CcmA; Region: ccmA; TIGR01189 1114966005638 Walker A/P-loop; other site 1114966005639 ATP binding site [chemical binding]; other site 1114966005640 Q-loop/lid; other site 1114966005641 ABC transporter signature motif; other site 1114966005642 Walker B; other site 1114966005643 D-loop; other site 1114966005644 H-loop/switch region; other site 1114966005645 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1114966005646 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1114966005647 Walker A/P-loop; other site 1114966005648 ATP binding site [chemical binding]; other site 1114966005649 Q-loop/lid; other site 1114966005650 ABC transporter signature motif; other site 1114966005651 Walker B; other site 1114966005652 D-loop; other site 1114966005653 H-loop/switch region; other site 1114966005654 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1114966005655 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 1114966005656 active site 1114966005657 SAM binding site [chemical binding]; other site 1114966005658 homodimer interface [polypeptide binding]; other site 1114966005659 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1114966005660 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1114966005661 substrate binding pocket [chemical binding]; other site 1114966005662 chain length determination region; other site 1114966005663 substrate-Mg2+ binding site; other site 1114966005664 catalytic residues [active] 1114966005665 aspartate-rich region 1; other site 1114966005666 active site lid residues [active] 1114966005667 aspartate-rich region 2; other site 1114966005668 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1114966005669 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1114966005670 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1114966005671 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1114966005672 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1114966005673 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1114966005674 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1114966005675 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1114966005676 NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839 1114966005677 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 1114966005678 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 1114966005679 4Fe-4S binding domain; Region: Fer4; pfam00037 1114966005680 4Fe-4S binding domain; Region: Fer4; pfam00037 1114966005681 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1114966005682 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1114966005683 NADH dehydrogenase subunit G; Validated; Region: PRK07860 1114966005684 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1114966005685 catalytic loop [active] 1114966005686 iron binding site [ion binding]; other site 1114966005687 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1114966005688 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 1114966005689 [4Fe-4S] binding site [ion binding]; other site 1114966005690 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 1114966005691 molybdopterin cofactor binding site; other site 1114966005692 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 1114966005693 SLBB domain; Region: SLBB; pfam10531 1114966005694 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 1114966005695 NADH dehydrogenase subunit E; Validated; Region: PRK07539 1114966005696 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1114966005697 putative dimer interface [polypeptide binding]; other site 1114966005698 [2Fe-2S] cluster binding site [ion binding]; other site 1114966005699 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 1114966005700 NADH dehydrogenase subunit D; Validated; Region: PRK06075 1114966005701 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 1114966005702 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 1114966005703 NADH dehydrogenase subunit B; Validated; Region: PRK06411 1114966005704 NADH dehydrogenase subunit A; Validated; Region: PRK07928 1114966005705 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 1114966005706 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1114966005707 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 1114966005708 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1114966005709 Walker A/P-loop; other site 1114966005710 ATP binding site [chemical binding]; other site 1114966005711 Q-loop/lid; other site 1114966005712 ABC transporter signature motif; other site 1114966005713 Walker B; other site 1114966005714 D-loop; other site 1114966005715 H-loop/switch region; other site 1114966005716 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1114966005717 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114966005718 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1114966005719 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1114966005720 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 1114966005721 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114966005722 Walker A/P-loop; other site 1114966005723 ATP binding site [chemical binding]; other site 1114966005724 Q-loop/lid; other site 1114966005725 ABC transporter signature motif; other site 1114966005726 Walker B; other site 1114966005727 D-loop; other site 1114966005728 H-loop/switch region; other site 1114966005729 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1114966005730 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1114966005731 Walker A/P-loop; other site 1114966005732 ATP binding site [chemical binding]; other site 1114966005733 Q-loop/lid; other site 1114966005734 ABC transporter signature motif; other site 1114966005735 Walker B; other site 1114966005736 D-loop; other site 1114966005737 H-loop/switch region; other site 1114966005738 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 1114966005739 UbiA prenyltransferase family; Region: UbiA; pfam01040 1114966005740 H+ Antiporter protein; Region: 2A0121; TIGR00900 1114966005741 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114966005742 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114966005743 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 1114966005744 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 1114966005745 DAK2 domain; Region: Dak2; cl03685 1114966005746 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 1114966005747 active pocket/dimerization site; other site 1114966005748 active site 1114966005749 phosphorylation site [posttranslational modification] 1114966005750 Deoxycytidylate deaminase [Nucleotide transport and metabolism]; Region: ComEB; COG2131 1114966005751 active site 1114966005752 Zn binding site [ion binding]; other site 1114966005753 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1114966005754 Cation efflux family; Region: Cation_efflux; cl00316 1114966005755 A subgroup of L-lactate dehydrogenases; Region: LDH_3; cd05290 1114966005756 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 1114966005757 NAD binding site [chemical binding]; other site 1114966005758 dimer interface [polypeptide binding]; other site 1114966005759 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1114966005760 substrate binding site [chemical binding]; other site 1114966005761 Patatin-like phospholipase; Region: Patatin; pfam01734 1114966005762 active site 1114966005763 nucleophile elbow; other site 1114966005764 Patatin-like phospholipase; Region: Patatin; pfam01734 1114966005765 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114966005766 UMP phosphatase; Provisional; Region: PRK10444 1114966005767 active site 1114966005768 motif I; other site 1114966005769 motif II; other site 1114966005770 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114966005771 Right handed beta helix region; Region: Beta_helix; pfam13229 1114966005772 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 1114966005773 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1114966005774 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1114966005775 Domain of unknown function (DUF4091); Region: DUF4091; pfam13320 1114966005776 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114966005777 dimer interface [polypeptide binding]; other site 1114966005778 conserved gate region; other site 1114966005779 putative PBP binding loops; other site 1114966005780 ABC-ATPase subunit interface; other site 1114966005781 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1114966005782 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114966005783 dimer interface [polypeptide binding]; other site 1114966005784 conserved gate region; other site 1114966005785 putative PBP binding loops; other site 1114966005786 ABC-ATPase subunit interface; other site 1114966005787 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1114966005788 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1114966005789 Bacterial SH3 domain; Region: SH3_3; pfam08239 1114966005790 Bacterial SH3 domain; Region: SH3_3; cl17532 1114966005791 Bacterial SH3 domain; Region: SH3_3; cl17532 1114966005792 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1114966005793 NlpC/P60 family; Region: NLPC_P60; cl17555 1114966005794 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1114966005795 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114966005796 dimer interface [polypeptide binding]; other site 1114966005797 conserved gate region; other site 1114966005798 putative PBP binding loops; other site 1114966005799 ABC-ATPase subunit interface; other site 1114966005800 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114966005801 dimer interface [polypeptide binding]; other site 1114966005802 conserved gate region; other site 1114966005803 putative PBP binding loops; other site 1114966005804 ABC-ATPase subunit interface; other site 1114966005805 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1114966005806 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1114966005807 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1114966005808 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 1114966005809 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1114966005810 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1114966005811 dimerization interface [polypeptide binding]; other site 1114966005812 putative ATP binding site [chemical binding]; other site 1114966005813 amidophosphoribosyltransferase; Provisional; Region: PRK07847 1114966005814 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1114966005815 active site 1114966005816 tetramer interface [polypeptide binding]; other site 1114966005817 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1114966005818 active site 1114966005819 hypothetical protein; Provisional; Region: PRK07907 1114966005820 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 1114966005821 active site 1114966005822 metal binding site [ion binding]; metal-binding site 1114966005823 dimer interface [polypeptide binding]; other site 1114966005824 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1114966005825 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1114966005826 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 1114966005827 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1114966005828 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1114966005829 glutamine binding [chemical binding]; other site 1114966005830 catalytic triad [active] 1114966005831 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1114966005832 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 1114966005833 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1114966005834 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1114966005835 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1114966005836 dimerization interface [polypeptide binding]; other site 1114966005837 ATP binding site [chemical binding]; other site 1114966005838 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1114966005839 dimerization interface [polypeptide binding]; other site 1114966005840 ATP binding site [chemical binding]; other site 1114966005841 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114966005842 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114966005843 putative substrate translocation pore; other site 1114966005844 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 1114966005845 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 1114966005846 Zn binding site [ion binding]; other site 1114966005847 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 1114966005848 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1114966005849 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1114966005850 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1114966005851 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 1114966005852 active site 1114966005853 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1114966005854 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 1114966005855 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 1114966005856 active site 1114966005857 catalytic triad [active] 1114966005858 oxyanion hole [active] 1114966005859 Thrombospondin type 3 repeat; Region: TSP_3; pfam02412 1114966005860 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1114966005861 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1114966005862 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1114966005863 putative active site [active] 1114966005864 catalytic triad [active] 1114966005865 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 1114966005866 ATP binding site [chemical binding]; other site 1114966005867 active site 1114966005868 substrate binding site [chemical binding]; other site 1114966005869 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 1114966005870 peroxiredoxin; Region: AhpC; TIGR03137 1114966005871 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1114966005872 dimer interface [polypeptide binding]; other site 1114966005873 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1114966005874 catalytic triad [active] 1114966005875 peroxidatic and resolving cysteines [active] 1114966005876 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 1114966005877 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1114966005878 catalytic residue [active] 1114966005879 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 1114966005880 catalytic residues [active] 1114966005881 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1114966005882 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1114966005883 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114966005884 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114966005885 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 1114966005886 dimerization interface [polypeptide binding]; other site 1114966005887 adenylosuccinate lyase; Region: purB; TIGR00928 1114966005888 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 1114966005889 tetramer interface [polypeptide binding]; other site 1114966005890 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1114966005891 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1114966005892 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1114966005893 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1114966005894 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1114966005895 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1114966005896 GDP-binding site [chemical binding]; other site 1114966005897 ACT binding site; other site 1114966005898 IMP binding site; other site 1114966005899 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114966005900 Coenzyme A binding pocket [chemical binding]; other site 1114966005901 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1114966005902 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114966005903 DNA-binding site [nucleotide binding]; DNA binding site 1114966005904 FCD domain; Region: FCD; pfam07729 1114966005905 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 1114966005906 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 1114966005907 putative active site cavity [active] 1114966005908 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1114966005909 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1114966005910 inhibitor site; inhibition site 1114966005911 active site 1114966005912 dimer interface [polypeptide binding]; other site 1114966005913 catalytic residue [active] 1114966005914 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1114966005915 putative sialic acid transporter; Provisional; Region: PRK03893 1114966005916 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114966005917 putative substrate translocation pore; other site 1114966005918 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114966005919 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 1114966005920 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1114966005921 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 1114966005922 G1 box; other site 1114966005923 putative GEF interaction site [polypeptide binding]; other site 1114966005924 GTP/Mg2+ binding site [chemical binding]; other site 1114966005925 Switch I region; other site 1114966005926 G2 box; other site 1114966005927 G3 box; other site 1114966005928 Switch II region; other site 1114966005929 G4 box; other site 1114966005930 G5 box; other site 1114966005931 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1114966005932 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1114966005933 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1114966005934 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1114966005935 carboxyltransferase (CT) interaction site; other site 1114966005936 biotinylation site [posttranslational modification]; other site 1114966005937 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 1114966005938 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1114966005939 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1114966005940 oxaloacetate decarboxylase; Provisional; Region: PRK12330 1114966005941 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1114966005942 active site 1114966005943 catalytic residues [active] 1114966005944 metal binding site [ion binding]; metal-binding site 1114966005945 homodimer binding site [polypeptide binding]; other site 1114966005946 PAS domain; Region: PAS_9; pfam13426 1114966005947 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1114966005948 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 1114966005949 active site 1114966005950 intersubunit interface [polypeptide binding]; other site 1114966005951 zinc binding site [ion binding]; other site 1114966005952 Na+ binding site [ion binding]; other site 1114966005953 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1114966005954 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1114966005955 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1114966005956 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1114966005957 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1114966005958 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1114966005959 SEC-C motif; Region: SEC-C; pfam02810 1114966005960 hypothetical protein; Provisional; Region: PRK04233 1114966005961 benzoate transport; Region: 2A0115; TIGR00895 1114966005962 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114966005963 putative substrate translocation pore; other site 1114966005964 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114966005965 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1114966005966 Clp amino terminal domain; Region: Clp_N; pfam02861 1114966005967 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114966005968 Walker A motif; other site 1114966005969 ATP binding site [chemical binding]; other site 1114966005970 Walker B motif; other site 1114966005971 arginine finger; other site 1114966005972 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114966005973 Walker A motif; other site 1114966005974 ATP binding site [chemical binding]; other site 1114966005975 Walker B motif; other site 1114966005976 arginine finger; other site 1114966005977 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1114966005978 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 1114966005979 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 1114966005980 Eukaryotic phosphomannomutase; Region: PMM; cl17107 1114966005981 fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377 1114966005982 catalytic residue [active] 1114966005983 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 1114966005984 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 1114966005985 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1114966005986 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1114966005987 Histidine kinase; Region: HisKA_3; pfam07730 1114966005988 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114966005989 ATP binding site [chemical binding]; other site 1114966005990 Mg2+ binding site [ion binding]; other site 1114966005991 G-X-G motif; other site 1114966005992 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1114966005993 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114966005994 active site 1114966005995 phosphorylation site [posttranslational modification] 1114966005996 intermolecular recognition site; other site 1114966005997 dimerization interface [polypeptide binding]; other site 1114966005998 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1114966005999 DNA binding residues [nucleotide binding] 1114966006000 dimerization interface [polypeptide binding]; other site 1114966006001 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1114966006002 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1114966006003 Walker A/P-loop; other site 1114966006004 ATP binding site [chemical binding]; other site 1114966006005 Q-loop/lid; other site 1114966006006 ABC transporter signature motif; other site 1114966006007 Walker B; other site 1114966006008 D-loop; other site 1114966006009 H-loop/switch region; other site 1114966006010 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1114966006011 FtsX-like permease family; Region: FtsX; pfam02687 1114966006012 FtsX-like permease family; Region: FtsX; pfam02687 1114966006013 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 1114966006014 nudix motif; other site 1114966006015 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1114966006016 Predicted permease [General function prediction only]; Region: COG2985 1114966006017 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 1114966006018 TrkA-C domain; Region: TrkA_C; pfam02080 1114966006019 TrkA-C domain; Region: TrkA_C; pfam02080 1114966006020 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 1114966006021 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1114966006022 6-hydroxycyclohex-1-ene-1-carboxyl-CoA dehydrogenase, N-benzyl-3-pyrrolidinol dehydrogenase, and other MDR family members; Region: hydroxyacyl_CoA_DH; cd08254 1114966006023 putative NAD(P) binding site [chemical binding]; other site 1114966006024 catalytic Zn binding site [ion binding]; other site 1114966006025 structural Zn binding site [ion binding]; other site 1114966006026 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1114966006027 active site 1114966006028 catalytic triad [active] 1114966006029 oxyanion hole [active] 1114966006030 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 1114966006031 DNA binding residues [nucleotide binding] 1114966006032 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1114966006033 putative dimer interface [polypeptide binding]; other site 1114966006034 chaperone protein DnaJ; Provisional; Region: PRK14295 1114966006035 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1114966006036 HSP70 interaction site [polypeptide binding]; other site 1114966006037 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1114966006038 Zn binding sites [ion binding]; other site 1114966006039 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1114966006040 dimer interface [polypeptide binding]; other site 1114966006041 GrpE; Region: GrpE; pfam01025 1114966006042 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1114966006043 dimer interface [polypeptide binding]; other site 1114966006044 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1114966006045 NAD-specific glutamate dehydrogenase; Region: NAD-GH; pfam10712 1114966006046 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1114966006047 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1114966006048 nucleotide binding site [chemical binding]; other site 1114966006049 NEF interaction site [polypeptide binding]; other site 1114966006050 SBD interface [polypeptide binding]; other site 1114966006051 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1114966006052 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1114966006053 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114966006054 active site 1114966006055 phosphorylation site [posttranslational modification] 1114966006056 intermolecular recognition site; other site 1114966006057 dimerization interface [polypeptide binding]; other site 1114966006058 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1114966006059 DNA binding site [nucleotide binding] 1114966006060 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1114966006061 intersubunit interface [polypeptide binding]; other site 1114966006062 active site 1114966006063 catalytic residue [active] 1114966006064 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1; cd01653 1114966006065 conserved cys residue [active] 1114966006066 FHA domain; Region: FHA; pfam00498 1114966006067 phosphopeptide binding site; other site 1114966006068 pyruvate phosphate dikinase; Provisional; Region: PRK09279 1114966006069 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1114966006070 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1114966006071 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1114966006072 PEP synthetase regulatory protein; Provisional; Region: PRK05339 1114966006073 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 1114966006074 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114966006075 S-adenosylmethionine binding site [chemical binding]; other site 1114966006076 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1114966006077 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1114966006078 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 1114966006079 active site 1114966006080 catalytic residues [active] 1114966006081 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 1114966006082 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 1114966006083 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1114966006084 potential frameshift: common BLAST hit: gi|50843498|ref|YP_056725.1| amidase 1114966006085 potential protein location (hypothetical protein TIA2EST2_10005 [Propionibacterium acnes TypeIA2 P.acn33]) that overlaps RNA (tRNA-G) 1114966006086 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 1114966006087 putative active site [active] 1114966006088 homotetrameric interface [polypeptide binding]; other site 1114966006089 metal binding site [ion binding]; metal-binding site 1114966006090 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 1114966006091 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 1114966006092 active site 1114966006093 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 1114966006094 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114966006095 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1114966006096 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114966006097 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1114966006098 Walker A/P-loop; other site 1114966006099 ATP binding site [chemical binding]; other site 1114966006100 Q-loop/lid; other site 1114966006101 ABC transporter signature motif; other site 1114966006102 Walker B; other site 1114966006103 D-loop; other site 1114966006104 H-loop/switch region; other site 1114966006105 potential frameshift: common BLAST hit: gi|295131594|ref|YP_003582257.1| ABC transporter, ATP-binding protein 1114966006106 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; cl09823 1114966006107 EcsC protein family; Region: EcsC; pfam12787 1114966006108 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1114966006109 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1114966006110 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1114966006111 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 1114966006112 Walker A/P-loop; other site 1114966006113 ATP binding site [chemical binding]; other site 1114966006114 Q-loop/lid; other site 1114966006115 ABC transporter signature motif; other site 1114966006116 Walker B; other site 1114966006117 D-loop; other site 1114966006118 H-loop/switch region; other site 1114966006119 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1114966006120 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1114966006121 E3 interaction surface; other site 1114966006122 lipoyl attachment site [posttranslational modification]; other site 1114966006123 e3 binding domain; Region: E3_binding; pfam02817 1114966006124 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1114966006125 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1114966006126 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1114966006127 alpha subunit interface [polypeptide binding]; other site 1114966006128 TPP binding site [chemical binding]; other site 1114966006129 heterodimer interface [polypeptide binding]; other site 1114966006130 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1114966006131 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1114966006132 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1114966006133 TPP-binding site [chemical binding]; other site 1114966006134 tetramer interface [polypeptide binding]; other site 1114966006135 heterodimer interface [polypeptide binding]; other site 1114966006136 phosphorylation loop region [posttranslational modification] 1114966006137 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1114966006138 radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053 1114966006139 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1114966006140 FeS/SAM binding site; other site 1114966006141 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1114966006142 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1114966006143 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1114966006144 active site 1114966006145 metal binding site [ion binding]; metal-binding site 1114966006146 potential frameshift: common BLAST hit: gi|50843536|ref|YP_056763.1| 5'-nucleotidase 1114966006147 potential frameshift: common BLAST hit: gi|50843536|ref|YP_056763.1| 5'-nucleotidase 1114966006148 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114966006149 H-loop/switch region; other site 1114966006150 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1114966006151 WYL domain; Region: WYL; pfam13280 1114966006152 HTH domain; Region: HTH_11; pfam08279 1114966006153 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1114966006154 active site 1114966006155 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1114966006156 Integrase core domain; Region: rve_3; pfam13683 1114966006157 Lipase (class 2); Region: Lipase_2; pfam01674 1114966006158 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 1114966006159 CAMP factor (Cfa); Region: CAMP_factor; pfam07373 1114966006160 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1114966006161 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1114966006162 active site 1114966006163 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 1114966006164 proposed catalytic triad [active] 1114966006165 active site nucleophile [active] 1114966006166 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1114966006167 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114966006168 active site 1114966006169 phosphorylation site [posttranslational modification] 1114966006170 intermolecular recognition site; other site 1114966006171 dimerization interface [polypeptide binding]; other site 1114966006172 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1114966006173 DNA binding site [nucleotide binding] 1114966006174 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1114966006175 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114966006176 dimerization interface [polypeptide binding]; other site 1114966006177 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114966006178 dimer interface [polypeptide binding]; other site 1114966006179 phosphorylation site [posttranslational modification] 1114966006180 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114966006181 ATP binding site [chemical binding]; other site 1114966006182 Mg2+ binding site [ion binding]; other site 1114966006183 G-X-G motif; other site 1114966006184 Ntn-hydrolase superfamily, L-Asparaginase type 2-like enzymes. This family includes Glycosylasparaginase, Taspase 1 and L-Asparaginase type 2 enzymes. Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked...; Region: Ntn_Asparaginase_2_like; cl00635 1114966006185 Ntn-hydrolase superfamily, L-Asparaginase type 2-like enzymes. This family includes Glycosylasparaginase, Taspase 1 and L-Asparaginase type 2 enzymes. Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked...; Region: Ntn_Asparaginase_2_like; cl00635 1114966006186 active site 1114966006187 catalytic nucleophile [active] 1114966006188 dimer interface [polypeptide binding]; other site 1114966006189 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 1114966006190 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 1114966006191 active site 1114966006192 metal binding site [ion binding]; metal-binding site 1114966006193 nudix motif; other site 1114966006194 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1114966006195 YCII-related domain; Region: YCII; cl00999 1114966006196 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1114966006197 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 1114966006198 active site 1114966006199 FMN binding site [chemical binding]; other site 1114966006200 substrate binding site [chemical binding]; other site 1114966006201 homotetramer interface [polypeptide binding]; other site 1114966006202 catalytic residue [active] 1114966006203 metabolite-proton symporter; Region: 2A0106; TIGR00883 1114966006204 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114966006205 putative substrate translocation pore; other site 1114966006206 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK06539 1114966006207 ATP cone domain; Region: ATP-cone; pfam03477 1114966006208 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1114966006209 active site 1114966006210 dimer interface [polypeptide binding]; other site 1114966006211 catalytic residues [active] 1114966006212 effector binding site; other site 1114966006213 R2 peptide binding site; other site 1114966006214 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1114966006215 dimer interface [polypeptide binding]; other site 1114966006216 putative radical transfer pathway; other site 1114966006217 diiron center [ion binding]; other site 1114966006218 tyrosyl radical; other site 1114966006219 Bacterial PH domain; Region: DUF304; pfam03703 1114966006220 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1114966006221 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1114966006222 nucleotide binding site [chemical binding]; other site 1114966006223 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 1114966006224 ornithine carbamoyltransferase; Validated; Region: PRK02102 1114966006225 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 1114966006226 arginine-tRNA ligase; Region: PLN02286 1114966006227 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1114966006228 active site 1114966006229 HIGH motif; other site 1114966006230 KMSK motif region; other site 1114966006231 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1114966006232 tRNA binding surface [nucleotide binding]; other site 1114966006233 anticodon binding site; other site 1114966006234 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1114966006235 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1114966006236 active site 1114966006237 catalytic tetrad [active] 1114966006238 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1114966006239 putative active site [active] 1114966006240 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1114966006241 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1114966006242 active site 1114966006243 dimer interface [polypeptide binding]; other site 1114966006244 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1114966006245 dimer interface [polypeptide binding]; other site 1114966006246 active site 1114966006247 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1114966006248 active site 1114966006249 intersubunit interface [polypeptide binding]; other site 1114966006250 catalytic residue [active] 1114966006251 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1114966006252 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1114966006253 dimerization interface [polypeptide binding]; other site 1114966006254 DPS ferroxidase diiron center [ion binding]; other site 1114966006255 ion pore; other site 1114966006256 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1114966006257 ATP binding site [chemical binding]; other site 1114966006258 putative Mg++ binding site [ion binding]; other site 1114966006259 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1114966006260 nucleotide binding region [chemical binding]; other site 1114966006261 ATP-binding site [chemical binding]; other site 1114966006262 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 1114966006263 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 1114966006264 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1114966006265 FeS/SAM binding site; other site 1114966006266 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK07111 1114966006267 ATP cone domain; Region: ATP-cone; pfam03477 1114966006268 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1114966006269 Class III ribonucleotide reductase; Region: RNR_III; cd01675 1114966006270 active site 1114966006271 Zn binding site [ion binding]; other site 1114966006272 glycine loop; other site 1114966006273 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1114966006274 substrate binding site [chemical binding]; other site 1114966006275 Cutinase; Region: Cutinase; pfam01083 1114966006276 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1114966006277 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1114966006278 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1114966006279 NodB motif; other site 1114966006280 active site 1114966006281 catalytic site [active] 1114966006282 metal binding site [ion binding]; metal-binding site 1114966006283 TIGR03943 family protein; Region: TIGR03943 1114966006284 Predicted permease; Region: DUF318; cl17795 1114966006285 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1114966006286 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1114966006287 NodB motif; other site 1114966006288 active site 1114966006289 catalytic site [active] 1114966006290 metal binding site [ion binding]; metal-binding site 1114966006291 integral membrane protein MviN; Region: mviN; TIGR01695 1114966006292 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1114966006293 aspartate kinase; Reviewed; Region: PRK06635 1114966006294 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1114966006295 putative nucleotide binding site [chemical binding]; other site 1114966006296 putative catalytic residues [active] 1114966006297 putative Mg ion binding site [ion binding]; other site 1114966006298 putative aspartate binding site [chemical binding]; other site 1114966006299 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1114966006300 putative allosteric regulatory site; other site 1114966006301 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1114966006302 putative allosteric regulatory residue; other site 1114966006303 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1114966006304 Transglycosylase; Region: Transgly; pfam00912 1114966006305 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1114966006306 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 1114966006307 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1114966006308 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1114966006309 putative active site [active] 1114966006310 putative metal binding site [ion binding]; other site 1114966006311 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1114966006312 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1114966006313 proposed catalytic triad [active] 1114966006314 conserved cys residue [active] 1114966006315 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1114966006316 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1114966006317 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1114966006318 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1114966006319 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114966006320 ABC-ATPase subunit interface; other site 1114966006321 putative PBP binding loops; other site 1114966006322 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1114966006323 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1114966006324 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114966006325 dimer interface [polypeptide binding]; other site 1114966006326 conserved gate region; other site 1114966006327 putative PBP binding loops; other site 1114966006328 ABC-ATPase subunit interface; other site 1114966006329 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1114966006330 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1114966006331 Walker A/P-loop; other site 1114966006332 ATP binding site [chemical binding]; other site 1114966006333 Q-loop/lid; other site 1114966006334 ABC transporter signature motif; other site 1114966006335 Walker B; other site 1114966006336 D-loop; other site 1114966006337 H-loop/switch region; other site 1114966006338 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1114966006339 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1114966006340 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1114966006341 Walker A/P-loop; other site 1114966006342 ATP binding site [chemical binding]; other site 1114966006343 Q-loop/lid; other site 1114966006344 ABC transporter signature motif; other site 1114966006345 Walker B; other site 1114966006346 D-loop; other site 1114966006347 H-loop/switch region; other site 1114966006348 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1114966006349 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1114966006350 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1114966006351 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1114966006352 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1114966006353 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1114966006354 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1114966006355 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1114966006356 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1114966006357 urocanate hydratase; Provisional; Region: PRK05414 1114966006358 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1114966006359 allantoate amidohydrolase; Reviewed; Region: PRK09290 1114966006360 active site 1114966006361 metal binding site [ion binding]; metal-binding site 1114966006362 dimer interface [polypeptide binding]; other site 1114966006363 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 1114966006364 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1114966006365 active site 1114966006366 imidazolonepropionase; Provisional; Region: PRK14085 1114966006367 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 1114966006368 active site 1114966006369 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1114966006370 active sites [active] 1114966006371 tetramer interface [polypeptide binding]; other site 1114966006372 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 1114966006373 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09755 1114966006374 NAD-dependent deacetylase; Provisional; Region: PRK00481 1114966006375 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 1114966006376 NAD+ binding site [chemical binding]; other site 1114966006377 substrate binding site [chemical binding]; other site 1114966006378 Zn binding site [ion binding]; other site 1114966006379 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1114966006380 Bacterial SH3 domain; Region: SH3_3; pfam08239 1114966006381 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1114966006382 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1114966006383 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 1114966006384 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1114966006385 potassium/proton antiporter; Reviewed; Region: PRK05326 1114966006386 TrkA-C domain; Region: TrkA_C; pfam02080 1114966006387 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1114966006388 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1114966006389 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1114966006390 nucleoside/Zn binding site; other site 1114966006391 dimer interface [polypeptide binding]; other site 1114966006392 catalytic motif [active] 1114966006393 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 1114966006394 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1114966006395 active site 1114966006396 Uncharacterized conserved protein [Function unknown]; Region: COG3777 1114966006397 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1114966006398 active site 1114966006399 catalytic site [active] 1114966006400 PA2301 is an uncharacterized Pseudomonas aeruginosa protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's...; Region: PA2301; cd04939 1114966006401 putative deacylase active site [active] 1114966006402 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1114966006403 K+ potassium transporter; Region: K_trans; pfam02705 1114966006404 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1114966006405 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1114966006406 catalytic triad [active] 1114966006407 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1114966006408 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1114966006409 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1114966006410 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1114966006411 DNA binding site [nucleotide binding] 1114966006412 domain linker motif; other site 1114966006413 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 1114966006414 ligand binding site [chemical binding]; other site 1114966006415 dimerization interface (open form) [polypeptide binding]; other site 1114966006416 dimerization interface (closed form) [polypeptide binding]; other site 1114966006417 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1114966006418 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 1114966006419 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u2; cd11478 1114966006420 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1114966006421 Na binding site [ion binding]; other site 1114966006422 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1114966006423 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 1114966006424 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 1114966006425 NAD(P) binding site [chemical binding]; other site 1114966006426 argininosuccinate synthase; Validated; Region: PRK05370 1114966006427 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114966006428 putative substrate translocation pore; other site 1114966006429 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114966006430 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1114966006431 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1114966006432 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1114966006433 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1114966006434 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114966006435 active site 1114966006436 motif I; other site 1114966006437 motif II; other site 1114966006438 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114966006439 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1114966006440 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1114966006441 Walker A/P-loop; other site 1114966006442 ATP binding site [chemical binding]; other site 1114966006443 Q-loop/lid; other site 1114966006444 ABC transporter signature motif; other site 1114966006445 Walker B; other site 1114966006446 D-loop; other site 1114966006447 H-loop/switch region; other site 1114966006448 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1114966006449 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1114966006450 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1114966006451 non-specific DNA binding site [nucleotide binding]; other site 1114966006452 salt bridge; other site 1114966006453 sequence-specific DNA binding site [nucleotide binding]; other site 1114966006454 Cupin domain; Region: Cupin_2; pfam07883 1114966006455 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 1114966006456 B3/4 domain; Region: B3_4; pfam03483 1114966006457 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1114966006458 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1114966006459 Na binding site [ion binding]; other site 1114966006460 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 1114966006461 CIDE_N domain, found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) proteins, as well as CAD nuclease (caspase-activated DNase/DNA fragmentation factor, DFF40) and its inhibitor, ICAD(DFF45). These proteins are associated with...; Region: CIDE_N; cl02541 1114966006462 oxidoreductase; Provisional; Region: PRK10015 1114966006463 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1114966006464 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1114966006465 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1114966006466 Ligand binding site [chemical binding]; other site 1114966006467 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1114966006468 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1114966006469 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1114966006470 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1114966006471 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1114966006472 active site 1114966006473 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1114966006474 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1114966006475 Bacterial transcriptional regulator; Region: IclR; pfam01614 1114966006476 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 1114966006477 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1114966006478 nucleotide binding site/active site [active] 1114966006479 HIT family signature motif; other site 1114966006480 catalytic residue [active] 1114966006481 seryl-tRNA synthetase; Provisional; Region: PRK05431 1114966006482 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1114966006483 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1114966006484 dimer interface [polypeptide binding]; other site 1114966006485 active site 1114966006486 motif 1; other site 1114966006487 motif 2; other site 1114966006488 motif 3; other site 1114966006489 PRC-barrel domain; Region: PRC; pfam05239 1114966006490 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 1114966006491 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1114966006492 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 1114966006493 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1114966006494 phosphate binding motif [ion binding]; other site 1114966006495 Siderophore-interacting protein; Region: SIP; pfam04954 1114966006496 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 1114966006497 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1114966006498 Ferritin-like domain; Region: Ferritin; pfam00210 1114966006499 ferroxidase diiron center [ion binding]; other site 1114966006500 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1114966006501 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1114966006502 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1114966006503 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1114966006504 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1114966006505 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1114966006506 dimer interface [polypeptide binding]; other site 1114966006507 ssDNA binding site [nucleotide binding]; other site 1114966006508 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1114966006509 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1114966006510 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1114966006511 active site residue [active] 1114966006512 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1114966006513 active site 1114966006514 phosphorylation site [posttranslational modification] 1114966006515 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 1114966006516 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1114966006517 active site 1114966006518 P-loop; other site 1114966006519 phosphorylation site [posttranslational modification] 1114966006520 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1114966006521 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1114966006522 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1114966006523 acyl-activating enzyme (AAE) consensus motif; other site 1114966006524 putative AMP binding site [chemical binding]; other site 1114966006525 putative active site [active] 1114966006526 putative CoA binding site [chemical binding]; other site 1114966006527 endonuclease IV; Provisional; Region: PRK01060 1114966006528 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1114966006529 AP (apurinic/apyrimidinic) site pocket; other site 1114966006530 DNA interaction; other site 1114966006531 Metal-binding active site; metal-binding site 1114966006532 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1114966006533 classical (c) SDRs; Region: SDR_c; cd05233 1114966006534 NAD(P) binding site [chemical binding]; other site 1114966006535 active site 1114966006536 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1114966006537 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1114966006538 putative acyl-acceptor binding pocket; other site 1114966006539 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 1114966006540 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1114966006541 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1114966006542 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1114966006543 G5 domain; Region: G5; pfam07501 1114966006544 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1114966006545 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1114966006546 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1114966006547 metal-binding site [ion binding] 1114966006548 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1114966006549 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1114966006550 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1114966006551 metal-binding site [ion binding] 1114966006552 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 1114966006553 putative homodimer interface [polypeptide binding]; other site 1114966006554 putative homotetramer interface [polypeptide binding]; other site 1114966006555 putative allosteric switch controlling residues; other site 1114966006556 putative metal binding site [ion binding]; other site 1114966006557 putative homodimer-homodimer interface [polypeptide binding]; other site 1114966006558 replicative DNA helicase; Region: DnaB; TIGR00665 1114966006559 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1114966006560 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1114966006561 Walker A motif; other site 1114966006562 ATP binding site [chemical binding]; other site 1114966006563 Walker B motif; other site 1114966006564 DNA binding loops [nucleotide binding] 1114966006565 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 1114966006566 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 1114966006567 putative NAD(P) binding site [chemical binding]; other site 1114966006568 dimer interface [polypeptide binding]; other site 1114966006569 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1114966006570 active site 1114966006571 DNA binding site [nucleotide binding] 1114966006572 sn-glycerol-3-phosphate dehydrogenase subunit C; Provisional; Region: glpC; PRK11168 1114966006573 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 1114966006574 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1114966006575 glycerol-3-phosphate dehydrogenase, anaerobic, A subunit; Region: glycerol3P_GlpA; TIGR03377 1114966006576 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1114966006577 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 1114966006578 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1114966006579 dimerization interface [polypeptide binding]; other site 1114966006580 ligand binding site [chemical binding]; other site 1114966006581 NADP binding site [chemical binding]; other site 1114966006582 catalytic site [active] 1114966006583 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1114966006584 MarR family; Region: MarR_2; cl17246 1114966006585 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 1114966006586 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1114966006587 Cl- selectivity filter; other site 1114966006588 Cl- binding residues [ion binding]; other site 1114966006589 pore gating glutamate residue; other site 1114966006590 dimer interface [polypeptide binding]; other site 1114966006591 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1114966006592 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1114966006593 MarR family; Region: MarR_2; pfam12802 1114966006594 MarR family; Region: MarR_2; cl17246 1114966006595 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1114966006596 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1114966006597 active site 1114966006598 metal binding site [ion binding]; metal-binding site 1114966006599 Predicted ATPases [General function prediction only]; Region: COG1106 1114966006600 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1114966006601 Uncharacterized conserved protein [Function unknown]; Region: COG4717 1114966006602 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1114966006603 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 1114966006604 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114966006605 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1114966006606 WHG domain; Region: WHG; pfam13305 1114966006607 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1114966006608 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1114966006609 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114966006610 catalytic residue [active] 1114966006611 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1114966006612 putative deacylase active site [active] 1114966006613 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1114966006614 NAD synthetase; Reviewed; Region: nadE; PRK02628 1114966006615 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 1114966006616 multimer interface [polypeptide binding]; other site 1114966006617 active site 1114966006618 catalytic triad [active] 1114966006619 protein interface 1 [polypeptide binding]; other site 1114966006620 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1114966006621 homodimer interface [polypeptide binding]; other site 1114966006622 NAD binding pocket [chemical binding]; other site 1114966006623 ATP binding pocket [chemical binding]; other site 1114966006624 Mg binding site [ion binding]; other site 1114966006625 active-site loop [active] 1114966006626 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 1114966006627 6-phosphofructokinase, eukaryotic type; Region: 6PF1K_euk; TIGR02478 1114966006628 active site 1114966006629 ADP/pyrophosphate binding site [chemical binding]; other site 1114966006630 dimerization interface [polypeptide binding]; other site 1114966006631 allosteric effector site; other site 1114966006632 fructose-1,6-bisphosphate binding site; other site 1114966006633 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1114966006634 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1114966006635 hexamer interface [polypeptide binding]; other site 1114966006636 ligand binding site [chemical binding]; other site 1114966006637 putative active site [active] 1114966006638 NAD(P) binding site [chemical binding]; other site 1114966006639 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 1114966006640 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 1114966006641 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1114966006642 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1114966006643 Bacterial SH3 domain; Region: SH3_3; pfam08239 1114966006644 Bacterial SH3 domain; Region: SH3_3; pfam08239 1114966006645 Bacterial SH3 domain; Region: SH3_4; pfam06347 1114966006646 Bacterial SH3 domain; Region: SH3_4; pfam06347 1114966006647 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 1114966006648 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1114966006649 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1114966006650 dimer interface [polypeptide binding]; other site 1114966006651 Citrate synthase; Region: Citrate_synt; pfam00285 1114966006652 active site 1114966006653 citrylCoA binding site [chemical binding]; other site 1114966006654 NADH binding [chemical binding]; other site 1114966006655 cationic pore residues; other site 1114966006656 oxalacetate/citrate binding site [chemical binding]; other site 1114966006657 coenzyme A binding site [chemical binding]; other site 1114966006658 catalytic triad [active] 1114966006659 adenosine deaminase; Provisional; Region: PRK09358 1114966006660 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1114966006661 active site 1114966006662 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1114966006663 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1114966006664 hexamer interface [polypeptide binding]; other site 1114966006665 ligand binding site [chemical binding]; other site 1114966006666 putative active site [active] 1114966006667 NAD(P) binding site [chemical binding]; other site 1114966006668 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1114966006669 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1114966006670 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1114966006671 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1114966006672 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1114966006673 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 1114966006674 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1114966006675 catalytic residue [active] 1114966006676 D-Lysine 5,6-aminomutase alpha subunit; Region: Lys-AminoMut_A; pfam09043 1114966006677 D-Lysine 5,6-aminomutase alpha subunit; Region: Lys-AminoMut_A; pfam09043 1114966006678 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1114966006679 B12 binding site [chemical binding]; other site 1114966006680 MutL protein; Region: MutL; pfam13941 1114966006681 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 1114966006682 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815 1114966006683 active site 1114966006684 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1114966006685 dimer interface [polypeptide binding]; other site 1114966006686 substrate binding site [chemical binding]; other site 1114966006687 catalytic residue [active] 1114966006688 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 1114966006689 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 1114966006690 alanine racemase; Reviewed; Region: alr; PRK00053 1114966006691 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1114966006692 active site 1114966006693 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1114966006694 dimer interface [polypeptide binding]; other site 1114966006695 substrate binding site [chemical binding]; other site 1114966006696 catalytic residues [active] 1114966006697 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1114966006698 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 1114966006699 active site 1114966006700 substrate binding site [chemical binding]; other site 1114966006701 metal binding site [ion binding]; metal-binding site 1114966006702 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1114966006703 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 1114966006704 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1114966006705 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 1114966006706 active site 1114966006707 Substrate binding site; other site 1114966006708 Mg++ binding site; other site 1114966006709 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1114966006710 putative active site [active] 1114966006711 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1114966006712 Class II fumarases; Region: Fumarase_classII; cd01362 1114966006713 active site 1114966006714 tetramer interface [polypeptide binding]; other site 1114966006715 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1114966006716 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114966006717 dimer interface [polypeptide binding]; other site 1114966006718 conserved gate region; other site 1114966006719 putative PBP binding loops; other site 1114966006720 ABC-ATPase subunit interface; other site 1114966006721 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114966006722 dimer interface [polypeptide binding]; other site 1114966006723 conserved gate region; other site 1114966006724 putative PBP binding loops; other site 1114966006725 ABC-ATPase subunit interface; other site 1114966006726 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1114966006727 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1114966006728 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1114966006729 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1114966006730 DNA binding site [nucleotide binding] 1114966006731 domain linker motif; other site 1114966006732 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 1114966006733 putative dimerization interface [polypeptide binding]; other site 1114966006734 putative ligand binding site [chemical binding]; other site 1114966006735 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 1114966006736 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1114966006737 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1114966006738 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1114966006739 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 1114966006740 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1114966006741 active site 1114966006742 NTP binding site [chemical binding]; other site 1114966006743 metal binding triad [ion binding]; metal-binding site 1114966006744 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1114966006745 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1114966006746 Zn2+ binding site [ion binding]; other site 1114966006747 Mg2+ binding site [ion binding]; other site 1114966006748 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1114966006749 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1114966006750 ATP binding site [chemical binding]; other site 1114966006751 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1114966006752 glycerol kinase; Provisional; Region: glpK; PRK00047 1114966006753 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 1114966006754 N- and C-terminal domain interface [polypeptide binding]; other site 1114966006755 active site 1114966006756 MgATP binding site [chemical binding]; other site 1114966006757 catalytic site [active] 1114966006758 metal binding site [ion binding]; metal-binding site 1114966006759 putative homotetramer interface [polypeptide binding]; other site 1114966006760 glycerol binding site [chemical binding]; other site 1114966006761 homodimer interface [polypeptide binding]; other site 1114966006762 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 1114966006763 amphipathic channel; other site 1114966006764 Asn-Pro-Ala signature motifs; other site 1114966006765 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1114966006766 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1114966006767 DNA binding residues [nucleotide binding] 1114966006768 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1114966006769 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1114966006770 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1114966006771 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 1114966006772 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1114966006773 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1114966006774 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1114966006775 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 1114966006776 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1114966006777 probable active site [active] 1114966006778 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114966006779 putative substrate translocation pore; other site 1114966006780 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1114966006781 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1114966006782 substrate binding pocket [chemical binding]; other site 1114966006783 OsmC-like protein; Region: OsmC; pfam02566 1114966006784 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1114966006785 catalytic residues [active] 1114966006786 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1114966006787 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1114966006788 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1114966006789 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1114966006790 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 1114966006791 non-specific DNA interactions [nucleotide binding]; other site 1114966006792 DNA binding site [nucleotide binding] 1114966006793 sequence specific DNA binding site [nucleotide binding]; other site 1114966006794 putative cAMP binding site [chemical binding]; other site 1114966006795 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1114966006796 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1114966006797 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1114966006798 TPP-binding site [chemical binding]; other site 1114966006799 dimer interface [polypeptide binding]; other site 1114966006800 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1114966006801 PYR/PP interface [polypeptide binding]; other site 1114966006802 dimer interface [polypeptide binding]; other site 1114966006803 TPP binding site [chemical binding]; other site 1114966006804 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1114966006805 ribulokinase; Provisional; Region: PRK04123 1114966006806 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 1114966006807 N- and C-terminal domain interface [polypeptide binding]; other site 1114966006808 active site 1114966006809 MgATP binding site [chemical binding]; other site 1114966006810 catalytic site [active] 1114966006811 metal binding site [ion binding]; metal-binding site 1114966006812 carbohydrate binding site [chemical binding]; other site 1114966006813 homodimer interface [polypeptide binding]; other site 1114966006814 Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175 1114966006815 active site 1114966006816 metal binding site [ion binding]; metal-binding site 1114966006817 Carbohydrate kinase and ribulose-phosphate 3-epimerase fusion proteins-like; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CarbK-RPE_like; cd07783 1114966006818 Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069 1114966006819 N- and C-terminal domain interface [polypeptide binding]; other site 1114966006820 active site 1114966006821 MgATP binding site [chemical binding]; other site 1114966006822 catalytic site [active] 1114966006823 metal binding site [ion binding]; metal-binding site 1114966006824 putative carbohydrate binding site [chemical binding]; other site 1114966006825 putative homodimer interface [polypeptide binding]; other site 1114966006826 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1114966006827 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114966006828 active site 1114966006829 motif I; other site 1114966006830 motif II; other site 1114966006831 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114966006832 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 1114966006833 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 1114966006834 active site 1114966006835 Zn2+ binding site [ion binding]; other site 1114966006836 intersubunit interface [polypeptide binding]; other site 1114966006837 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1114966006838 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1114966006839 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1114966006840 mannonate dehydratase; Provisional; Region: PRK03906 1114966006841 mannonate dehydratase; Region: uxuA; TIGR00695 1114966006842 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1114966006843 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1114966006844 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1114966006845 glucuronate isomerase; Reviewed; Region: PRK02925 1114966006846 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 1114966006847 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1114966006848 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1114966006849 DNA binding site [nucleotide binding] 1114966006850 domain linker motif; other site 1114966006851 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1114966006852 dimerization interface [polypeptide binding]; other site 1114966006853 ligand binding site [chemical binding]; other site 1114966006854 MFS/sugar transport protein; Region: MFS_2; pfam13347 1114966006855 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1114966006856 putative alpha-glucosidase; Provisional; Region: PRK10658 1114966006857 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1114966006858 Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599 1114966006859 putative active site [active] 1114966006860 putative catalytic site [active] 1114966006861 beta-D-glucuronidase; Provisional; Region: PRK10150 1114966006862 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1114966006863 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1114966006864 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1114966006865 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 1114966006866 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1114966006867 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1114966006868 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114966006869 homodimer interface [polypeptide binding]; other site 1114966006870 catalytic residue [active] 1114966006871 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 1114966006872 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1114966006873 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1114966006874 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 1114966006875 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 1114966006876 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1114966006877 ParB-like nuclease domain; Region: ParB; smart00470 1114966006878 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1114966006879 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1114966006880 P-loop; other site 1114966006881 Magnesium ion binding site [ion binding]; other site 1114966006882 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1114966006883 Magnesium ion binding site [ion binding]; other site 1114966006884 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 1114966006885 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 1114966006886 Alanine racemase, N-terminal domain; Region: Ala_racemase_N; pfam01168 1114966006887 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1114966006888 catalytic residue [active] 1114966006889 FemAB family; Region: FemAB; pfam02388 1114966006890 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1114966006891 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 1114966006892 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1114966006893 G-X-X-G motif; other site 1114966006894 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1114966006895 RxxxH motif; other site 1114966006896 putative inner membrane protein translocase component YidC; Provisional; Region: PRK01315 1114966006897 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1114966006898 Ribonuclease P; Region: Ribonuclease_P; cl00457 1114966006899 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399