-- dump date 20140620_001210 -- class Genbank::misc_feature -- table misc_feature_note -- id note 754252000001 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 754252000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 754252000003 Walker A motif; other site 754252000004 ATP binding site [chemical binding]; other site 754252000005 Walker B motif; other site 754252000006 arginine finger; other site 754252000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 754252000008 DnaA box-binding interface [nucleotide binding]; other site 754252000009 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754252000010 putative substrate translocation pore; other site 754252000011 Major Facilitator Superfamily; Region: MFS_1; pfam07690 754252000012 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754252000013 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 754252000014 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 754252000015 DNA binding residues [nucleotide binding] 754252000016 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 754252000017 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 754252000018 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 754252000019 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 754252000020 NAD(P) binding site [chemical binding]; other site 754252000021 active site 754252000022 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 754252000023 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 754252000024 Walker A/P-loop; other site 754252000025 ATP binding site [chemical binding]; other site 754252000026 Q-loop/lid; other site 754252000027 ABC transporter signature motif; other site 754252000028 Walker B; other site 754252000029 D-loop; other site 754252000030 H-loop/switch region; other site 754252000031 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 754252000032 FtsX-like permease family; Region: FtsX; pfam02687 754252000033 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 754252000034 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 754252000035 FtsX-like permease family; Region: FtsX; pfam02687 754252000036 DNA polymerase III subunit beta; Validated; Region: PRK07761 754252000037 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 754252000038 putative DNA binding surface [nucleotide binding]; other site 754252000039 dimer interface [polypeptide binding]; other site 754252000040 beta-clamp/clamp loader binding surface; other site 754252000041 beta-clamp/translesion DNA polymerase binding surface; other site 754252000042 recombination protein F; Reviewed; Region: recF; PRK00064 754252000043 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 754252000044 Walker A/P-loop; other site 754252000045 ATP binding site [chemical binding]; other site 754252000046 Q-loop/lid; other site 754252000047 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754252000048 ABC transporter signature motif; other site 754252000049 Walker B; other site 754252000050 D-loop; other site 754252000051 H-loop/switch region; other site 754252000052 Protein of unknown function (DUF721); Region: DUF721; cl02324 754252000053 S-layer homology domain; Region: SLH; pfam00395 754252000054 S-layer homology domain; Region: SLH; pfam00395 754252000055 S-layer homology domain; Region: SLH; pfam00395 754252000056 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 754252000057 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 754252000058 Transposase; Region: DDE_Tnp_ISL3; pfam01610 754252000059 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 754252000060 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 754252000061 Mg2+ binding site [ion binding]; other site 754252000062 G-X-G motif; other site 754252000063 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 754252000064 anchoring element; other site 754252000065 dimer interface [polypeptide binding]; other site 754252000066 ATP binding site [chemical binding]; other site 754252000067 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 754252000068 active site 754252000069 putative metal-binding site [ion binding]; other site 754252000070 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 754252000071 DNA gyrase subunit A; Validated; Region: PRK05560 754252000072 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 754252000073 CAP-like domain; other site 754252000074 active site 754252000075 primary dimer interface [polypeptide binding]; other site 754252000076 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 754252000077 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 754252000078 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 754252000079 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 754252000080 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 754252000081 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 754252000082 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 754252000083 Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361 754252000084 putative ligand binding pocket/active site [active] 754252000085 putative metal binding site [ion binding]; other site 754252000086 AmmeMemoRadiSam system protein A; Region: AmmeMemoSam_A; TIGR04335 754252000087 AMMECR1; Region: AMMECR1; pfam01871 754252000088 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 754252000089 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 754252000090 FeS/SAM binding site; other site 754252000091 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 754252000092 Putative bacterial sensory transduction regulator; Region: YbjN; cl15834 754252000093 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 754252000094 LacI family transcriptional regulator 754252000095 Periplasmic binding protein-like domain; Region: Peripla_BP_3; pfam13377 754252000096 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 754252000097 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 754252000098 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 754252000099 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 754252000100 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754252000101 putative substrate translocation pore; other site 754252000102 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754252000103 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 754252000104 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754252000105 active site 754252000106 phosphorylation site [posttranslational modification] 754252000107 intermolecular recognition site; other site 754252000108 dimerization interface [polypeptide binding]; other site 754252000109 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 754252000110 DNA binding residues [nucleotide binding] 754252000111 Putative sensor; Region: Sensor; pfam13796 754252000112 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 754252000113 Histidine kinase; Region: HisKA_3; pfam07730 754252000114 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754252000115 metabolite-proton symporter; Region: 2A0106; TIGR00883 754252000116 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754252000117 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 754252000118 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 754252000119 metal binding site [ion binding]; metal-binding site 754252000120 dimer interface [polypeptide binding]; other site 754252000121 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 754252000122 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754252000123 Walker A/P-loop; other site 754252000124 ATP binding site [chemical binding]; other site 754252000125 Q-loop/lid; other site 754252000126 ABC transporter signature motif; other site 754252000127 Walker B; other site 754252000128 D-loop; other site 754252000129 H-loop/switch region; other site 754252000130 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 754252000131 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 754252000132 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754252000133 Walker A/P-loop; other site 754252000134 ATP binding site [chemical binding]; other site 754252000135 Q-loop/lid; other site 754252000136 ABC transporter signature motif; other site 754252000137 Walker B; other site 754252000138 D-loop; other site 754252000139 H-loop/switch region; other site 754252000140 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 754252000141 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 754252000142 hexamer interface [polypeptide binding]; other site 754252000143 ligand binding site [chemical binding]; other site 754252000144 putative active site [active] 754252000145 NAD(P) binding site [chemical binding]; other site 754252000146 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 754252000147 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 754252000148 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 754252000149 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 754252000150 Acylphosphatase; Region: Acylphosphatase; pfam00708 754252000151 Uncharacterized conserved protein [Function unknown]; Region: COG1739 754252000152 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 754252000153 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 754252000154 FMN binding site [chemical binding]; other site 754252000155 dimer interface [polypeptide binding]; other site 754252000156 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 754252000157 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein; Region: PTPS_related; pfam10131 754252000158 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 754252000159 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 754252000160 substrate binding site; other site 754252000161 tetramer interface; other site 754252000162 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 754252000163 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 754252000164 Ligand binding site; other site 754252000165 Putative Catalytic site; other site 754252000166 DXD motif; other site 754252000167 Uncharacterized conserved protein (DUF2304); Region: DUF2304; pfam10066 754252000168 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 754252000169 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 754252000170 active site 754252000171 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 754252000172 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 754252000173 Probable Catalytic site; other site 754252000174 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 754252000175 active site 754252000176 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 754252000177 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 754252000178 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 754252000179 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 754252000180 NADP binding site [chemical binding]; other site 754252000181 active site 754252000182 putative substrate binding site [chemical binding]; other site 754252000183 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 754252000184 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 754252000185 NAD binding site [chemical binding]; other site 754252000186 substrate binding site [chemical binding]; other site 754252000187 homodimer interface [polypeptide binding]; other site 754252000188 active site 754252000189 LGFP repeat; Region: LGFP; pfam08310 754252000190 LGFP repeat; Region: LGFP; pfam08310 754252000191 LGFP repeat; Region: LGFP; pfam08310 754252000192 LGFP repeat; Region: LGFP; pfam08310 754252000193 LGFP repeat; Region: LGFP; pfam08310 754252000194 LGFP repeat; Region: LGFP; pfam08310 754252000195 LGFP repeat; Region: LGFP; pfam08310 754252000196 LGFP repeat; Region: LGFP; pfam08310 754252000197 LGFP repeat; Region: LGFP; pfam08310 754252000198 LGFP repeat; Region: LGFP; pfam08310 754252000199 LGFP repeat; Region: LGFP; pfam08310 754252000200 LGFP repeat; Region: LGFP; pfam08310 754252000201 LGFP repeat; Region: LGFP; pfam08310 754252000202 LGFP repeat; Region: LGFP; pfam08310 754252000203 LGFP repeat; Region: LGFP; pfam08310 754252000204 LGFP repeat; Region: LGFP; pfam08310 754252000205 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 754252000206 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 754252000207 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 754252000208 UDP-galactopyranose mutase; Region: GLF; pfam03275 754252000209 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 754252000210 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 754252000211 active site 754252000212 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 754252000213 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 754252000214 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 754252000215 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 754252000216 Walker A/P-loop; other site 754252000217 ATP binding site [chemical binding]; other site 754252000218 Q-loop/lid; other site 754252000219 ABC transporter signature motif; other site 754252000220 Walker B; other site 754252000221 D-loop; other site 754252000222 H-loop/switch region; other site 754252000223 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 754252000224 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 754252000225 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 754252000226 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 754252000227 active site 754252000228 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 754252000229 active site 754252000230 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 754252000231 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 754252000232 active site 754252000233 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 754252000234 catalytic residues [active] 754252000235 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 754252000236 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 754252000237 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 754252000238 putative acyl-acceptor binding pocket; other site 754252000239 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 754252000240 classical (c) SDRs; Region: SDR_c; cd05233 754252000241 NAD(P) binding site [chemical binding]; other site 754252000242 active site 754252000243 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 754252000244 propionate/acetate kinase; Provisional; Region: PRK12379 754252000245 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 754252000246 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 754252000247 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 754252000248 ATP binding site [chemical binding]; other site 754252000249 putative Mg++ binding site [ion binding]; other site 754252000250 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 754252000251 nucleotide binding region [chemical binding]; other site 754252000252 ATP-binding site [chemical binding]; other site 754252000253 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 754252000254 DNA-binding interface [nucleotide binding]; DNA binding site 754252000255 putative transposase OrfB; Reviewed; Region: PHA02517 754252000256 HTH-like domain; Region: HTH_21; pfam13276 754252000257 Integrase core domain; Region: rve; pfam00665 754252000258 Integrase core domain; Region: rve_3; pfam13683 754252000259 GIY-YIG type nucleases (URI domain); Region: GIYc; smart00465 754252000260 GIY-YIG motif/motif A; other site 754252000261 active site 754252000262 catalytic site [active] 754252000263 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 754252000264 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 754252000265 Transposase; Region: DDE_Tnp_ISL3; pfam01610 754252000266 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 754252000267 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 754252000268 FeS/SAM binding site; other site 754252000269 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 754252000270 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 754252000271 uncharacterized ygcE-like proteins; Region: FGGY_ygcE_like; cd07779 754252000272 putative N- and C-terminal domain interface [polypeptide binding]; other site 754252000273 putative active site [active] 754252000274 MgATP binding site [chemical binding]; other site 754252000275 catalytic site [active] 754252000276 metal binding site [ion binding]; metal-binding site 754252000277 putative carbohydrate binding site [chemical binding]; other site 754252000278 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GpsA; COG0240 754252000279 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 754252000280 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 754252000281 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 754252000282 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 754252000283 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 754252000284 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 754252000285 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 754252000286 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 754252000287 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 754252000288 dimerization interface [polypeptide binding]; other site 754252000289 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 754252000290 dimer interface [polypeptide binding]; other site 754252000291 phosphorylation site [posttranslational modification] 754252000292 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 754252000293 ATP binding site [chemical binding]; other site 754252000294 Mg2+ binding site [ion binding]; other site 754252000295 G-X-G motif; other site 754252000296 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 754252000297 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754252000298 active site 754252000299 phosphorylation site [posttranslational modification] 754252000300 intermolecular recognition site; other site 754252000301 dimerization interface [polypeptide binding]; other site 754252000302 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 754252000303 DNA binding site [nucleotide binding] 754252000304 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 754252000305 proposed catalytic triad [active] 754252000306 active site nucleophile [active] 754252000307 Low molecular weight phosphatase family; Region: LMWPc; cd00115 754252000308 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 754252000309 active site 754252000310 Membrane protein of unknown function; Region: DUF360; pfam04020 754252000311 ornithine carbamoyltransferase; Validated; Region: PRK02102 754252000312 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 754252000313 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 754252000314 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 754252000315 active site 754252000316 SUMO-1 interface [polypeptide binding]; other site 754252000317 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 754252000318 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 754252000319 Transposase; Region: DDE_Tnp_ISL3; pfam01610 754252000320 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 754252000321 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 754252000322 ATP + D-gluconic acid <=> ADP + 6-phospho-D-gluconate 754252000323 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 754252000324 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 754252000325 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 754252000326 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 754252000327 Binuclear center (active site) [active] 754252000328 K-pathway; other site 754252000329 Putative proton exit pathway; other site 754252000330 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 754252000331 Transposase; Region: HTH_Tnp_1; pfam01527 754252000332 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 754252000333 putative transposase OrfB; Reviewed; Region: PHA02517 754252000334 HTH-like domain; Region: HTH_21; pfam13276 754252000335 Integrase core domain; Region: rve; pfam00665 754252000336 Integrase core domain; Region: rve_3; pfam13683 754252000339 putative transposase OrfB; Reviewed; Region: PHA02517 754252000340 HTH-like domain; Region: HTH_21; pfam13276 754252000341 Integrase core domain; Region: rve; pfam00665 754252000342 Integrase core domain; Region: rve_3; cl15866 754252000343 Transposase; Region: HTH_Tnp_1; cl17663 754252000344 putative transposase OrfB; Reviewed; Region: PHA02517 754252000345 HTH-like domain; Region: HTH_21; pfam13276 754252000346 Integrase core domain; Region: rve; pfam00665 754252000347 Integrase core domain; Region: rve_3; pfam13683 754252000348 Transposase; Region: HTH_Tnp_1; cl17663 754252000349 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 754252000350 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 754252000351 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 754252000352 N- and C-terminal domain interface [polypeptide binding]; other site 754252000353 active site 754252000354 catalytic site [active] 754252000355 metal binding site [ion binding]; metal-binding site 754252000356 carbohydrate binding site [chemical binding]; other site 754252000357 ATP binding site [chemical binding]; other site 754252000358 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 754252000359 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973 754252000360 putative DNA binding site [nucleotide binding]; other site 754252000361 catalytic residue [active] 754252000362 putative H2TH interface [polypeptide binding]; other site 754252000363 putative catalytic residues [active] 754252000364 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 754252000365 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 754252000366 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 754252000367 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 754252000368 active site 754252000369 ATP binding site [chemical binding]; other site 754252000370 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 754252000371 substrate binding site [chemical binding]; other site 754252000372 activation loop (A-loop); other site 754252000373 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 754252000374 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 754252000375 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 754252000376 Citrate synthase; Region: Citrate_synt; pfam00285 754252000377 oxalacetate binding site [chemical binding]; other site 754252000378 citrylCoA binding site [chemical binding]; other site 754252000379 coenzyme A binding site [chemical binding]; other site 754252000380 catalytic triad [active] 754252000381 SdpI/YhfL protein family; Region: SdpI; pfam13630 754252000382 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 754252000383 active site 754252000384 catalytic residues [active] 754252000385 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 754252000386 alanine racemase; Reviewed; Region: alr; PRK00053 754252000387 active site 754252000388 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 754252000389 dimer interface [polypeptide binding]; other site 754252000390 substrate binding site [chemical binding]; other site 754252000391 catalytic residues [active] 754252000392 phosphopantothenoylcysteine decarboxylase; Validated; Region: PRK07313 754252000393 Flavoprotein; Region: Flavoprotein; pfam02441 754252000394 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 754252000395 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 754252000396 dimerization interface [polypeptide binding]; other site 754252000397 putative DNA binding site [nucleotide binding]; other site 754252000398 putative Zn2+ binding site [ion binding]; other site 754252000400 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 754252000401 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 754252000402 Transposase; Region: DDE_Tnp_ISL3; pfam01610 754252000406 Transposase; Region: HTH_Tnp_1; cl17663 754252000407 putative transposase OrfB; Reviewed; Region: PHA02517 754252000408 HTH-like domain; Region: HTH_21; pfam13276 754252000409 Integrase core domain; Region: rve; pfam00665 754252000410 Integrase core domain; Region: rve_3; cl15866 754252000411 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 754252000412 ADP-ribose binding site [chemical binding]; other site 754252000413 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 754252000414 active site 754252000415 catalytic site [active] 754252000416 substrate binding site [chemical binding]; other site 754252000419 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 754252000420 type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497 754252000421 HsdM N-terminal domain; Region: HsdM_N; pfam12161 754252000422 Methyltransferase domain; Region: Methyltransf_26; pfam13659 754252000423 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 754252000424 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 754252000425 Walker A/P-loop; other site 754252000426 ATP binding site [chemical binding]; other site 754252000427 Q-loop/lid; other site 754252000428 ABC transporter signature motif; other site 754252000429 Walker B; other site 754252000430 D-loop; other site 754252000431 H-loop/switch region; other site 754252000432 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 754252000433 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 754252000434 Walker A/P-loop; other site 754252000435 ATP binding site [chemical binding]; other site 754252000436 Q-loop/lid; other site 754252000437 ABC transporter signature motif; other site 754252000438 Walker B; other site 754252000439 D-loop; other site 754252000440 H-loop/switch region; other site 754252000441 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 754252000442 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 754252000443 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 754252000444 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 754252000445 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 754252000446 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 754252000447 aminodeoxychorismate synthase, component I, clade 2; Region: PabB-clade2; TIGR01824 754252000448 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 754252000449 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 754252000450 Aminotransferase class IV; Region: Aminotran_4; pfam01063 754252000451 substrate-cofactor binding pocket; other site 754252000452 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754252000453 catalytic residue [active] 754252000454 prephenate dehydratase; Provisional; Region: PRK11898 754252000455 Prephenate dehydratase; Region: PDT; pfam00800 754252000456 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 754252000457 putative L-Phe binding site [chemical binding]; other site 754252000458 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 754252000459 active site 754252000460 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 754252000461 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 754252000462 seryl-tRNA synthetase; Provisional; Region: PRK05431 754252000463 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 754252000464 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 754252000465 dimer interface [polypeptide binding]; other site 754252000466 active site 754252000467 motif 1; other site 754252000468 motif 2; other site 754252000469 motif 3; other site 754252000470 Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719 754252000471 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 754252000472 active site turn [active] 754252000473 phosphorylation site [posttranslational modification] 754252000474 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 754252000475 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 754252000476 HPr interaction site; other site 754252000477 glycerol kinase (GK) interaction site [polypeptide binding]; other site 754252000478 active site 754252000479 phosphorylation site [posttranslational modification] 754252000480 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 754252000481 HPr interaction site; other site 754252000482 glycerol kinase (GK) interaction site [polypeptide binding]; other site 754252000483 active site 754252000484 phosphorylation site [posttranslational modification] 754252000485 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 754252000486 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 754252000487 Beta-Casp domain; Region: Beta-Casp; smart01027 754252000488 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 754252000489 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 754252000490 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754252000491 active site 754252000492 phosphorylation site [posttranslational modification] 754252000493 intermolecular recognition site; other site 754252000494 dimerization interface [polypeptide binding]; other site 754252000495 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 754252000496 DNA binding site [nucleotide binding] 754252000497 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 754252000498 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 754252000499 dimer interface [polypeptide binding]; other site 754252000500 phosphorylation site [posttranslational modification] 754252000501 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 754252000502 ATP binding site [chemical binding]; other site 754252000503 Mg2+ binding site [ion binding]; other site 754252000504 G-X-G motif; other site 754252000505 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 754252000506 dimer interface [polypeptide binding]; other site 754252000507 catalytic triad [active] 754252000508 peroxidatic and resolving cysteines [active] 754252000509 NAD-dependent deacetylase; Provisional; Region: PRK00481 754252000510 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 754252000511 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 754252000512 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 754252000513 argininosuccinate synthase; Validated; Region: PRK05370 754252000514 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 754252000515 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 754252000516 NAD(P) binding site [chemical binding]; other site 754252000517 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 754252000518 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 754252000519 Transcriptional regulator [Transcription]; Region: LytR; COG1316 754252000520 VanZ like family; Region: VanZ; cl01971 754252000521 short chain dehydrogenase; Provisional; Region: PRK08219 754252000522 classical (c) SDRs; Region: SDR_c; cd05233 754252000523 NAD(P) binding site [chemical binding]; other site 754252000524 active site 754252000525 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 754252000526 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 754252000527 active site 754252000528 catalytic site [active] 754252000529 metal binding site [ion binding]; metal-binding site 754252000530 dimer interface [polypeptide binding]; other site 754252000531 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 754252000532 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 754252000533 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 754252000534 shikimate binding site; other site 754252000535 NAD(P) binding site [chemical binding]; other site 754252000536 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 754252000537 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 754252000538 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 754252000539 active site 754252000540 catalytic tetrad [active] 754252000541 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 754252000542 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 754252000543 FtsX-like permease family; Region: FtsX; pfam02687 754252000544 FtsX-like permease family; Region: FtsX; pfam02687 754252000545 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 754252000546 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 754252000547 Walker A/P-loop; other site 754252000548 ATP binding site [chemical binding]; other site 754252000549 Q-loop/lid; other site 754252000550 ABC transporter signature motif; other site 754252000551 Walker B; other site 754252000552 D-loop; other site 754252000553 H-loop/switch region; other site 754252000554 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 754252000555 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754252000556 active site 754252000557 phosphorylation site [posttranslational modification] 754252000558 intermolecular recognition site; other site 754252000559 dimerization interface [polypeptide binding]; other site 754252000560 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 754252000561 DNA binding residues [nucleotide binding] 754252000562 dimerization interface [polypeptide binding]; other site 754252000563 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 754252000564 Histidine kinase; Region: HisKA_3; pfam07730 754252000565 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 754252000566 ATP binding site [chemical binding]; other site 754252000567 Mg2+ binding site [ion binding]; other site 754252000568 G-X-G motif; other site 754252000569 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 754252000570 active site 754252000571 catalytic site [active] 754252000572 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 754252000573 Predicted acetyltransferase [General function prediction only]; Region: COG2388 754252000574 Protein of unknown function (DUF1271); Region: DUF1271; pfam06902 754252000575 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 754252000576 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 754252000577 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 754252000578 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 754252000579 active site 754252000580 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 754252000581 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 754252000582 active site 754252000583 catalytic site [active] 754252000584 substrate binding site [chemical binding]; other site 754252000585 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 754252000586 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 754252000587 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 754252000588 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 754252000589 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 754252000590 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 754252000591 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754252000592 Walker A/P-loop; other site 754252000593 ATP binding site [chemical binding]; other site 754252000594 Q-loop/lid; other site 754252000595 ABC transporter signature motif; other site 754252000596 Walker B; other site 754252000597 D-loop; other site 754252000598 H-loop/switch region; other site 754252000599 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 754252000600 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 754252000601 Walker A/P-loop; other site 754252000602 ATP binding site [chemical binding]; other site 754252000603 Q-loop/lid; other site 754252000604 ABC transporter signature motif; other site 754252000605 Walker B; other site 754252000606 D-loop; other site 754252000607 H-loop/switch region; other site 754252000608 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 754252000609 metal binding site [ion binding]; metal-binding site 754252000610 dimer interface [polypeptide binding]; other site 754252000611 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 754252000612 putative transporter; Provisional; Region: PRK10504 754252000613 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754252000614 putative substrate translocation pore; other site 754252000615 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754252000616 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 754252000617 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 754252000618 Domain of unknown function DUF77; Region: DUF77; pfam01910 754252000619 putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771 754252000620 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 754252000621 4Fe-4S binding domain; Region: Fer4; pfam00037 754252000622 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 754252000623 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 754252000624 dimer interface [polypeptide binding]; other site 754252000625 PYR/PP interface [polypeptide binding]; other site 754252000626 TPP binding site [chemical binding]; other site 754252000627 substrate binding site [chemical binding]; other site 754252000628 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 754252000629 Domain of unknown function; Region: EKR; pfam10371 754252000630 4Fe-4S binding domain; Region: Fer4_6; pfam12837 754252000631 4Fe-4S binding domain; Region: Fer4; pfam00037 754252000632 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 754252000633 TPP-binding site [chemical binding]; other site 754252000634 dimer interface [polypeptide binding]; other site 754252000635 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565 754252000636 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 754252000637 phosphate binding site [ion binding]; other site 754252000638 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 754252000639 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 754252000640 tetrameric interface [polypeptide binding]; other site 754252000641 NAD binding site [chemical binding]; other site 754252000642 catalytic residues [active] 754252000643 substrate binding site [chemical binding]; other site 754252000644 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 754252000645 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 754252000646 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 754252000647 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 754252000648 Int/Topo IB signature motif; other site 754252000649 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 754252000650 Fic family protein [Function unknown]; Region: COG3177 754252000651 Fic/DOC family; Region: Fic; pfam02661 754252000652 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 754252000653 dimerization interface [polypeptide binding]; other site 754252000654 putative DNA binding site [nucleotide binding]; other site 754252000655 putative Zn2+ binding site [ion binding]; other site 754252000656 Methyltransferase domain; Region: Methyltransf_31; pfam13847 754252000657 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754252000658 S-adenosylmethionine binding site [chemical binding]; other site 754252000661 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 754252000662 putative hydrophobic ligand binding site [chemical binding]; other site 754252000663 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 754252000664 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 754252000665 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 754252000666 DNA binding residues [nucleotide binding] 754252000667 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 754252000668 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 754252000669 putative DNA binding site [nucleotide binding]; other site 754252000670 putative Zn2+ binding site [ion binding]; other site 754252000671 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 754252000672 NADH(P)-binding; Region: NAD_binding_10; pfam13460 754252000673 NAD binding site [chemical binding]; other site 754252000674 substrate binding site [chemical binding]; other site 754252000675 putative active site [active] 754252000676 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 754252000677 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 754252000678 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 754252000679 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 754252000680 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 754252000681 Walker A/P-loop; other site 754252000682 ATP binding site [chemical binding]; other site 754252000683 Q-loop/lid; other site 754252000684 ABC transporter signature motif; other site 754252000685 Walker B; other site 754252000686 D-loop; other site 754252000687 H-loop/switch region; other site 754252000688 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 754252000689 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 754252000690 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754252000691 Walker A/P-loop; other site 754252000692 ATP binding site [chemical binding]; other site 754252000693 Q-loop/lid; other site 754252000694 ABC transporter signature motif; other site 754252000695 Walker B; other site 754252000696 D-loop; other site 754252000697 H-loop/switch region; other site 754252000698 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 754252000699 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 754252000700 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 754252000701 dihydropteroate synthase; Region: DHPS; TIGR01496 754252000702 substrate binding pocket [chemical binding]; other site 754252000703 dimer interface [polypeptide binding]; other site 754252000704 inhibitor binding site; inhibition site 754252000705 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 754252000706 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 754252000707 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 754252000708 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 754252000709 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754252000710 Walker A/P-loop; other site 754252000711 ATP binding site [chemical binding]; other site 754252000712 Q-loop/lid; other site 754252000713 ABC transporter signature motif; other site 754252000714 Walker B; other site 754252000715 D-loop; other site 754252000716 H-loop/switch region; other site 754252000717 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 754252000718 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 754252000719 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 754252000720 dimer interface [polypeptide binding]; other site 754252000721 putative anticodon binding site; other site 754252000722 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 754252000723 motif 1; other site 754252000724 dimer interface [polypeptide binding]; other site 754252000725 active site 754252000726 motif 2; other site 754252000727 motif 3; other site 754252000728 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754252000729 Methyltransferase domain; Region: Methyltransf_31; pfam13847 754252000730 S-adenosylmethionine binding site [chemical binding]; other site 754252000731 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 754252000732 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 754252000733 TPP-binding site [chemical binding]; other site 754252000734 heterodimer interface [polypeptide binding]; other site 754252000735 tetramer interface [polypeptide binding]; other site 754252000736 phosphorylation loop region [posttranslational modification] 754252000737 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 754252000738 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 754252000739 alpha subunit interface [polypeptide binding]; other site 754252000740 TPP binding site [chemical binding]; other site 754252000741 heterodimer interface [polypeptide binding]; other site 754252000742 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 754252000743 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 754252000744 E3 interaction surface; other site 754252000745 lipoyl attachment site [posttranslational modification]; other site 754252000746 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 754252000747 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 754252000748 putative septation inhibitor protein; Reviewed; Region: PRK02251 754252000749 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 754252000750 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 754252000751 Glutamine amidotransferase class-I; Region: GATase; pfam00117 754252000752 glutamine binding [chemical binding]; other site 754252000753 catalytic triad [active] 754252000754 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 754252000755 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 754252000756 active site 754252000757 catalytic tetrad [active] 754252000758 EXLDI protein; Region: EXLDI; TIGR04342 754252000759 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 754252000760 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 754252000761 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 754252000762 Transposase; Region: HTH_Tnp_1; cl17663 754252000763 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 754252000764 putative transposase OrfB; Reviewed; Region: PHA02517 754252000765 HTH-like domain; Region: HTH_21; pfam13276 754252000766 Integrase core domain; Region: rve; pfam00665 754252000767 Integrase core domain; Region: rve_3; pfam13683 754252000768 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 754252000769 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 754252000770 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 754252000771 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 754252000772 Helix-turn-helix domain; Region: HTH_38; pfam13936 754252000773 Integrase core domain; Region: rve; pfam00665 754252000774 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 754252000775 Transposase; Region: DDE_Tnp_ISL3; pfam01610 754252000776 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 754252000777 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 754252000778 NAD(P) binding site [chemical binding]; other site 754252000779 active site 754252000780 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 754252000781 MFS/sugar transport protein; Region: MFS_2; pfam13347 754252000782 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 754252000783 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 754252000784 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 754252000785 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 754252000786 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 754252000788 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 754252000789 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 754252000790 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 754252000791 putative active site [active] 754252000792 Homeodomain-like domain; Region: HTH_23; pfam13384 754252000793 Integrase core domain; Region: rve; pfam00665 754252000794 Integrase core domain; Region: rve_3; pfam13683 754252000795 crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354 754252000796 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 754252000797 active site 754252000798 crotonobetainyl-CoA:carnitine CoA-transferase; Provisional; Region: PRK03525 754252000799 CoA-transferase family III; Region: CoA_transf_3; pfam02515 754252000800 putative crotonobetaine/carnitine-CoA ligase; Validated; Region: caiC; PRK08008 754252000801 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 754252000802 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 754252000803 acyl-activating enzyme (AAE) consensus motif; other site 754252000804 AMP binding site [chemical binding]; other site 754252000805 active site 754252000806 CoA binding site [chemical binding]; other site 754252000807 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 754252000808 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 754252000809 active site 2 [active] 754252000810 active site 1 [active] 754252000811 benzoate transport; Region: 2A0115; TIGR00895 754252000812 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754252000813 putative substrate translocation pore; other site 754252000814 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 754252000815 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 754252000816 Ligand Binding Site [chemical binding]; other site 754252000817 Electron transfer flavoprotein domain; Region: ETF; pfam01012 754252000818 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 754252000819 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 754252000820 oxidoreductase; Provisional; Region: PRK10015 754252000821 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 754252000822 CIDE_N domain, found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) proteins, as well as CAD nuclease (caspase-activated DNase/DNA fragmentation factor, DFF40) and its inhibitor, ICAD(DFF45). These proteins are associated with...; Region: CIDE_N; cl02541 754252000823 putative heterodimer interaction sites [polypeptide binding]; other site 754252000824 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 754252000825 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 754252000826 ATP binding site [chemical binding]; other site 754252000827 putative Mg++ binding site [ion binding]; other site 754252000828 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 754252000829 putative active site [active] 754252000830 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 754252000831 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 754252000832 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 754252000833 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 754252000834 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 754252000835 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 754252000836 active site 754252000837 HIGH motif; other site 754252000838 KMSK motif region; other site 754252000839 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 754252000840 tRNA binding surface [nucleotide binding]; other site 754252000841 anticodon binding site; other site 754252000842 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 754252000843 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 754252000844 Walker A/P-loop; other site 754252000845 ATP binding site [chemical binding]; other site 754252000846 Q-loop/lid; other site 754252000847 ABC transporter signature motif; other site 754252000848 Walker B; other site 754252000849 D-loop; other site 754252000850 H-loop/switch region; other site 754252000851 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 754252000852 ABC-ATPase subunit interface; other site 754252000853 dimer interface [polypeptide binding]; other site 754252000854 putative PBP binding regions; other site 754252000855 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 754252000856 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 754252000857 ABC-ATPase subunit interface; other site 754252000858 dimer interface [polypeptide binding]; other site 754252000859 putative PBP binding regions; other site 754252000860 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 754252000861 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 754252000862 siderophore binding site; other site 754252000863 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 754252000864 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 754252000865 nucleotide binding site [chemical binding]; other site 754252000866 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 754252000867 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 754252000868 transmembrane helices; other site 754252000869 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 754252000870 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 754252000871 NAD(P) binding site [chemical binding]; other site 754252000872 active site 754252000873 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 754252000874 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 754252000875 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 754252000876 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 754252000877 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 754252000878 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 754252000879 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 754252000880 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754252000881 putative substrate translocation pore; other site 754252000882 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754252000883 metallophosphoesterase, PPA1498 family; Region: P_acnes_RR; cl17623 754252000884 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 754252000885 MgtC family; Region: MgtC; pfam02308 754252000886 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 754252000887 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 754252000888 Transposase; Region: DDE_Tnp_ISL3; pfam01610 754252000889 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 754252000890 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754252000891 putative substrate translocation pore; other site 754252000892 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 754252000893 active site 754252000894 8-oxo-dGMP binding site [chemical binding]; other site 754252000895 nudix motif; other site 754252000896 metal binding site [ion binding]; metal-binding site 754252000897 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 754252000898 additional DNA contacts [nucleotide binding]; other site 754252000899 mismatch recognition site; other site 754252000900 active site 754252000901 zinc binding site [ion binding]; other site 754252000902 DNA intercalation site [nucleotide binding]; other site 754252000903 AAA-like domain; Region: AAA_10; pfam12846 754252000904 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 754252000905 cofactor binding site; other site 754252000906 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 754252000907 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 754252000908 DNA binding site [nucleotide binding] 754252000909 substrate interaction site [chemical binding]; other site 754252000910 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 754252000911 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 754252000912 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 754252000913 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 754252000914 substrate binding site [chemical binding]; other site 754252000915 ATP binding site [chemical binding]; other site 754252000916 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 754252000917 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 754252000918 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 754252000919 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 754252000920 active site 754252000921 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 754252000922 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754252000923 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754252000924 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 754252000925 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 754252000926 dimer interface [polypeptide binding]; other site 754252000927 active site 754252000928 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 754252000929 AMP binding site [chemical binding]; other site 754252000930 active site 754252000931 acyl-activating enzyme (AAE) consensus motif; other site 754252000932 CoA binding site [chemical binding]; other site 754252000933 CAAX protease self-immunity; Region: Abi; pfam02517 754252000934 CAAX protease self-immunity; Region: Abi; cl00558 754252000935 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 754252000936 Ferritin-like domain; Region: Ferritin; pfam00210 754252000937 dimerization interface [polypeptide binding]; other site 754252000938 DPS ferroxidase diiron center [ion binding]; other site 754252000939 ion pore; other site 754252000940 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 754252000941 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 754252000942 Transposase; Region: DDE_Tnp_ISL3; pfam01610 754252000943 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 754252000944 Transposase; Region: DDE_Tnp_ISL3; pfam01610 754252000945 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 754252000946 DNA-binding interface [nucleotide binding]; DNA binding site 754252000947 putative transposase OrfB; Reviewed; Region: PHA02517 754252000948 HTH-like domain; Region: HTH_21; pfam13276 754252000949 Integrase core domain; Region: rve; pfam00665 754252000950 Integrase core domain; Region: rve_3; pfam13683 754252000951 BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418 754252000952 active site 754252000953 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 754252000954 Transposase; Region: DDE_Tnp_ISL3; pfam01610 754252000957 Predicted helicase [General function prediction only]; Region: COG4889 754252000958 Restriction endonuclease; Region: Mrr_cat_2; pfam13156 754252000959 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 754252000960 ATP binding site [chemical binding]; other site 754252000961 putative Mg++ binding site [ion binding]; other site 754252000962 helicase superfamily c-terminal domain; Region: HELICc; smart00490 754252000963 nucleotide binding region [chemical binding]; other site 754252000964 ATP-binding site [chemical binding]; other site 754252000965 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cl00251 754252000966 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 754252000967 salt bridge; other site 754252000968 sequence-specific DNA binding site [nucleotide binding]; other site 754252000969 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 754252000970 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 754252000971 Transposase; Region: DDE_Tnp_ISL3; pfam01610 754252000973 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 754252000974 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 754252000975 Transposase; Region: DDE_Tnp_ISL3; pfam01610 754252000976 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 754252000977 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 754252000978 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 754252000979 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 754252000980 NAD binding site [chemical binding]; other site 754252000981 ligand binding site [chemical binding]; other site 754252000982 catalytic site [active] 754252000983 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 754252000984 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 754252000985 NADP binding site [chemical binding]; other site 754252000986 homodimer interface [polypeptide binding]; other site 754252000987 active site 754252000988 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 754252000989 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 754252000990 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 754252000991 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 754252000992 Uncharacterized conserved protein [Function unknown]; Region: COG4198 754252000993 LssY C-terminus; Region: LssY_C; pfam14067 754252000994 Isochorismatase family; Region: Isochorismatase; pfam00857 754252000995 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 754252000996 catalytic triad [active] 754252000997 dimer interface [polypeptide binding]; other site 754252000998 conserved cis-peptide bond; other site 754252000999 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 754252001000 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 754252001001 active site 754252001002 catalytic tetrad [active] 754252001003 YwiC-like protein; Region: YwiC; pfam14256 754252001004 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 754252001005 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754252001006 S-adenosylmethionine binding site [chemical binding]; other site 754252001007 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 754252001008 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 754252001009 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 754252001010 Mrr N-terminal domain; Region: Mrr_N; pfam14338 754252001011 Restriction endonuclease; Region: Mrr_cat; pfam04471 754252001012 PEP synthetase regulatory protein; Provisional; Region: PRK05339 754252001013 pyruvate phosphate dikinase; Provisional; Region: PRK09279 754252001014 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 754252001015 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 754252001016 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 754252001017 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 754252001018 phosphopeptide binding site; other site 754252001019 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 754252001020 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 754252001021 substrate binding site [chemical binding]; other site 754252001022 dimer interface [polypeptide binding]; other site 754252001023 ATP binding site [chemical binding]; other site 754252001024 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 754252001025 HAMP domain; Region: HAMP; pfam00672 754252001026 dimerization interface [polypeptide binding]; other site 754252001027 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 754252001028 dimer interface [polypeptide binding]; other site 754252001029 phosphorylation site [posttranslational modification] 754252001030 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 754252001031 ATP binding site [chemical binding]; other site 754252001032 Mg2+ binding site [ion binding]; other site 754252001033 G-X-G motif; other site 754252001034 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 754252001035 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754252001036 active site 754252001037 phosphorylation site [posttranslational modification] 754252001038 intermolecular recognition site; other site 754252001039 dimerization interface [polypeptide binding]; other site 754252001040 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 754252001041 DNA binding site [nucleotide binding] 754252001042 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 754252001043 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 754252001044 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 754252001045 Walker A/P-loop; other site 754252001046 ATP binding site [chemical binding]; other site 754252001047 Q-loop/lid; other site 754252001048 ABC transporter signature motif; other site 754252001049 Walker B; other site 754252001050 D-loop; other site 754252001051 H-loop/switch region; other site 754252001052 NIL domain; Region: NIL; cl09633 754252001053 ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism]; Region: AbcD; COG2011 754252001054 dimer interface [polypeptide binding]; other site 754252001055 conserved gate region; other site 754252001056 ABC-ATPase subunit interface; other site 754252001057 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 754252001058 S-layer homology domain; Region: SLH; pfam00395 754252001059 S-layer homology domain; Region: SLH; pfam00395 754252001060 S-layer homology domain; Region: SLH; pfam00395 754252001061 Predicted transcriptional regulators [Transcription]; Region: COG1695 754252001062 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 754252001063 ABC1 family; Region: ABC1; cl17513 754252001064 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 754252001065 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 754252001066 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 754252001067 dimer interface [polypeptide binding]; other site 754252001068 substrate binding site [chemical binding]; other site 754252001069 ATP binding site [chemical binding]; other site 754252001070 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 754252001071 thiamine phosphate binding site [chemical binding]; other site 754252001072 active site 754252001073 pyrophosphate binding site [ion binding]; other site 754252001074 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 754252001075 substrate binding site [chemical binding]; other site 754252001076 multimerization interface [polypeptide binding]; other site 754252001077 ATP binding site [chemical binding]; other site 754252001078 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 754252001079 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 754252001080 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 754252001081 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_4; cd03407 754252001082 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 754252001083 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 754252001084 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 754252001085 Transposase; Region: DDE_Tnp_ISL3; pfam01610 754252001086 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 754252001087 DNA-binding interface [nucleotide binding]; DNA binding site 754252001088 putative transposase OrfB; Reviewed; Region: PHA02517 754252001089 HTH-like domain; Region: HTH_21; pfam13276 754252001090 Integrase core domain; Region: rve; pfam00665 754252001091 Integrase core domain; Region: rve_3; pfam13683 754252001092 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b1; cd09203 754252001093 PLD-like domain; Region: PLDc_2; pfam13091 754252001094 putative homodimer interface [polypeptide binding]; other site 754252001095 putative active site [active] 754252001096 catalytic site [active] 754252001097 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 754252001098 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 754252001099 ATP binding site [chemical binding]; other site 754252001100 putative Mg++ binding site [ion binding]; other site 754252001101 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 754252001102 nucleotide binding region [chemical binding]; other site 754252001103 ATP-binding site [chemical binding]; other site 754252001104 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 754252001105 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 754252001106 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 754252001107 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 754252001108 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 754252001109 putative NAD(P) binding site [chemical binding]; other site 754252001110 dimer interface [polypeptide binding]; other site 754252001111 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 754252001112 CRISPR spacer 754252001113 CRISPR spacer 754252001114 CRISPR spacer 754252001115 CRISPR spacer 754252001116 CRISPR spacer 754252001117 CRISPR spacer 754252001118 CRISPR spacer 754252001119 CRISPR spacer 754252001120 CRISPR spacer 754252001121 CRISPR spacer 754252001122 CRISPR spacer 754252001123 CRISPR spacer 754252001124 CRISPR spacer 754252001125 CRISPR spacer 754252001126 CRISPR spacer 754252001127 CRISPR spacer 754252001128 CRISPR spacer 754252001129 CRISPR spacer 754252001130 CRISPR spacer 754252001131 CRISPR spacer 754252001132 CRISPR spacer 754252001133 CRISPR spacer 754252001134 CRISPR spacer 754252001135 CRISPR spacer 754252001136 CRISPR spacer 754252001137 CRISPR spacer 754252001138 CRISPR spacer 754252001139 CRISPR spacer 754252001140 CRISPR spacer 754252001141 CRISPR spacer 754252001142 CRISPR spacer 754252001143 CRISPR spacer 754252001144 CRISPR spacer 754252001145 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 754252001146 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 754252001147 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 754252001148 CRISPR/Cas system-associated RAMP superfamily protein Csb3; Region: Csb3_I-U; cd09764 754252001149 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 754252001150 CRISPR-associated helicase Cas3, subtype Dpsyc; Region: cas3_GSU0051; TIGR02621 754252001151 CRISPR-associated protein GSU0054/csb2, Dpsyc system; Region: cas_GSU0054; TIGR02165 754252001152 CRISPR/Cas system-associated protein Csb1; Region: Csb1_I-U; cl09834 754252001153 threonine dehydratase; Validated; Region: PRK08639 754252001154 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 754252001155 tetramer interface [polypeptide binding]; other site 754252001156 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754252001157 catalytic residue [active] 754252001158 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 754252001159 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 754252001160 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 754252001161 putative DNA binding site [nucleotide binding]; other site 754252001162 putative Zn2+ binding site [ion binding]; other site 754252001163 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 754252001164 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 754252001165 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 754252001166 Cna protein B-type domain; Region: Cna_B; pfam05738 754252001167 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 754252001168 active site 754252001169 putative catalytic site [active] 754252001170 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 754252001171 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 754252001172 Walker A motif; other site 754252001173 ATP binding site [chemical binding]; other site 754252001174 Walker B motif; other site 754252001175 arginine finger; other site 754252001176 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 754252001177 recombination protein RecR; Reviewed; Region: recR; PRK00076 754252001178 RecR protein; Region: RecR; pfam02132 754252001179 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 754252001180 putative active site [active] 754252001181 putative metal-binding site [ion binding]; other site 754252001182 tetramer interface [polypeptide binding]; other site 754252001183 Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060 754252001184 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 754252001185 active site 754252001186 HIGH motif; other site 754252001187 nucleotide binding site [chemical binding]; other site 754252001188 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 754252001189 active site 754252001190 KMSKS motif; other site 754252001191 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 754252001192 tRNA binding surface [nucleotide binding]; other site 754252001193 anticodon binding site; other site 754252001194 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 754252001195 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 754252001196 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 754252001197 aspartate kinase; Reviewed; Region: PRK06635 754252001198 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 754252001199 putative nucleotide binding site [chemical binding]; other site 754252001200 putative catalytic residues [active] 754252001201 putative Mg ion binding site [ion binding]; other site 754252001202 putative aspartate binding site [chemical binding]; other site 754252001203 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 754252001204 putative allosteric regulatory site; other site 754252001205 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 754252001206 putative allosteric regulatory residue; other site 754252001207 integral membrane protein MviN; Region: mviN; TIGR01695 754252001208 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 754252001209 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 754252001210 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 754252001211 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 754252001212 putative substrate binding site [chemical binding]; other site 754252001213 putative ATP binding site [chemical binding]; other site 754252001214 Amino acid permease; Region: AA_permease_2; pfam13520 754252001215 Transmembrane secretion effector; Region: MFS_3; pfam05977 754252001216 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754252001217 putative substrate translocation pore; other site 754252001218 Predicted permease [General function prediction only]; Region: COG2985 754252001219 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 754252001220 TrkA-C domain; Region: TrkA_C; pfam02080 754252001221 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 754252001222 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 754252001223 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 754252001224 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 754252001225 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 754252001226 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 754252001227 adenylosuccinate lyase; Region: purB; TIGR00928 754252001228 tetramer interface [polypeptide binding]; other site 754252001229 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 754252001230 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 754252001231 ATP binding site [chemical binding]; other site 754252001232 active site 754252001233 substrate binding site [chemical binding]; other site 754252001234 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 754252001235 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 754252001236 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 754252001237 putative active site [active] 754252001238 catalytic triad [active] 754252001239 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 754252001240 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 754252001241 polyol permease family; Region: 2A0118; TIGR00897 754252001242 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754252001243 putative substrate translocation pore; other site 754252001244 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 754252001245 DNA-binding interface [nucleotide binding]; DNA binding site 754252001246 putative transposase OrfB; Reviewed; Region: PHA02517 754252001247 HTH-like domain; Region: HTH_21; pfam13276 754252001248 Integrase core domain; Region: rve; pfam00665 754252001249 Integrase core domain; Region: rve_3; pfam13683 754252001250 Phage capsid family; Region: Phage_capsid; pfam05065 754252001251 Bifunctional DNA primase/polymerase, N-terminal; Region: Prim-Pol; pfam09250 754252001252 nucleotide binding site [chemical binding]; other site 754252001253 AAA domain; Region: AAA_25; pfam13481 754252001254 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 754252001255 Walker A motif; other site 754252001256 ATP binding site [chemical binding]; other site 754252001257 Walker B motif; other site 754252001258 Helix-turn-helix domain; Region: HTH_17; cl17695 754252001259 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 754252001260 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 754252001261 active site 754252001262 Int/Topo IB signature motif; other site 754252001263 DNA binding site [nucleotide binding] 754252001264 Cutinase; Region: Cutinase; pfam01083 754252001265 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 754252001266 substrate binding site [chemical binding]; other site 754252001267 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 754252001268 ATP binding site [chemical binding]; other site 754252001269 putative Mg++ binding site [ion binding]; other site 754252001270 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 754252001271 nucleotide binding region [chemical binding]; other site 754252001272 ATP-binding site [chemical binding]; other site 754252001273 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 754252001274 Class I aldolases; Region: Aldolase_Class_I; cl17187 754252001275 catalytic residue [active] 754252001276 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 754252001277 NlpC/P60 family; Region: NLPC_P60; pfam00877 754252001278 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 754252001279 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 754252001280 active site 754252001281 dimer interface [polypeptide binding]; other site 754252001282 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 754252001283 dimer interface [polypeptide binding]; other site 754252001284 active site 754252001285 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 754252001286 putative active site [active] 754252001287 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 754252001288 Beta-lactamase; Region: Beta-lactamase; pfam00144 754252001289 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 754252001290 FAD binding domain; Region: FAD_binding_4; pfam01565 754252001291 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 754252001292 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 754252001293 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 754252001294 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 754252001295 Lipase (class 2); Region: Lipase_2; pfam01674 754252001296 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754252001297 AAA domain; Region: AAA_23; pfam13476 754252001298 Walker A/P-loop; other site 754252001299 ATP binding site [chemical binding]; other site 754252001300 Q-loop/lid; other site 754252001301 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 754252001302 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 754252001303 ABC transporter signature motif; other site 754252001304 Walker B; other site 754252001305 D-loop; other site 754252001306 H-loop/switch region; other site 754252001307 exonuclease subunit SbcD; Provisional; Region: PRK10966 754252001308 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 754252001309 active site 754252001310 metal binding site [ion binding]; metal-binding site 754252001311 DNA binding site [nucleotide binding] 754252001312 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 754252001313 adenosine deaminase; Provisional; Region: PRK09358 754252001314 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 754252001315 active site 754252001316 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 754252001317 PAS domain; Region: PAS_9; pfam13426 754252001318 putative active site [active] 754252001319 heme pocket [chemical binding]; other site 754252001320 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 754252001321 pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720 754252001322 PYR/PP interface [polypeptide binding]; other site 754252001323 dimer interface [polypeptide binding]; other site 754252001324 tetramer interface [polypeptide binding]; other site 754252001325 TPP binding site [chemical binding]; other site 754252001326 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 754252001327 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 754252001328 TPP-binding site [chemical binding]; other site 754252001329 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 754252001330 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 754252001331 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 754252001332 MarR family; Region: MarR_2; pfam12802 754252001333 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 754252001334 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 754252001335 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 754252001336 NADH(P)-binding; Region: NAD_binding_10; pfam13460 754252001337 NAD(P) binding site [chemical binding]; other site 754252001338 active site 754252001339 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 754252001340 NADH(P)-binding; Region: NAD_binding_10; pfam13460 754252001341 NAD(P) binding site [chemical binding]; other site 754252001342 active site 754252001343 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 754252001344 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 754252001345 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 754252001346 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 754252001347 ATP binding site [chemical binding]; other site 754252001348 putative Mg++ binding site [ion binding]; other site 754252001349 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 754252001350 nucleotide binding region [chemical binding]; other site 754252001351 ATP-binding site [chemical binding]; other site 754252001352 Helicase associated domain (HA2); Region: HA2; pfam04408 754252001353 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 754252001354 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 754252001355 active site 754252001356 SAM binding site [chemical binding]; other site 754252001357 homodimer interface [polypeptide binding]; other site 754252001358 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 754252001359 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 754252001360 Walker A/P-loop; other site 754252001361 ATP binding site [chemical binding]; other site 754252001362 Q-loop/lid; other site 754252001363 ABC transporter signature motif; other site 754252001364 Walker B; other site 754252001365 D-loop; other site 754252001366 H-loop/switch region; other site 754252001367 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 754252001368 cobalt transport protein CbiN; Provisional; Region: PRK02898 754252001369 cobalt transport protein CbiM; Validated; Region: PRK08319 754252001370 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 754252001371 Transcriptional regulators [Transcription]; Region: FadR; COG2186 754252001372 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 754252001373 DNA-binding site [nucleotide binding]; DNA binding site 754252001374 FCD domain; Region: FCD; pfam07729 754252001375 fructuronate transporter; Provisional; Region: PRK10034; cl15264 754252001376 GntP family permease; Region: GntP_permease; pfam02447 754252001377 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 754252001378 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490 754252001379 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 754252001380 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 754252001381 nucleotide binding site [chemical binding]; other site 754252001382 NEF interaction site [polypeptide binding]; other site 754252001383 SBD interface [polypeptide binding]; other site 754252001384 GrpE; Region: GrpE; pfam01025 754252001385 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 754252001386 dimer interface [polypeptide binding]; other site 754252001387 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 754252001388 chaperone protein DnaJ; Provisional; Region: PRK14295 754252001389 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 754252001390 HSP70 interaction site [polypeptide binding]; other site 754252001391 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 754252001392 Zn binding sites [ion binding]; other site 754252001393 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 754252001394 dimer interface [polypeptide binding]; other site 754252001395 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 754252001396 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 754252001397 DNA binding residues [nucleotide binding] 754252001398 putative dimer interface [polypeptide binding]; other site 754252001399 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 754252001400 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 754252001401 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 754252001402 dimerization interface [polypeptide binding]; other site 754252001403 ATP binding site [chemical binding]; other site 754252001404 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 754252001405 dimerization interface [polypeptide binding]; other site 754252001406 ATP binding site [chemical binding]; other site 754252001407 hypothetical protein; Provisional; Region: PRK07907 754252001408 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 754252001409 active site 754252001410 metal binding site [ion binding]; metal-binding site 754252001411 dimer interface [polypeptide binding]; other site 754252001412 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 754252001413 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 754252001414 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 754252001415 Potassium binding sites [ion binding]; other site 754252001416 Cesium cation binding sites [ion binding]; other site 754252001417 AAA domain; Region: AAA_33; pfam13671 754252001418 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 754252001419 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 754252001420 amidophosphoribosyltransferase; Provisional; Region: PRK07847 754252001421 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 754252001422 active site 754252001423 tetramer interface [polypeptide binding]; other site 754252001424 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 754252001425 active site 754252001426 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 754252001427 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 754252001428 dimerization interface [polypeptide binding]; other site 754252001429 putative ATP binding site [chemical binding]; other site 754252001430 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 754252001431 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 754252001432 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 754252001433 Bromovirus movement protein; Region: Bromo_MP; pfam01573 754252001434 Bacterial SH3 domain; Region: SH3_3; pfam08239 754252001435 Bacterial SH3 domain; Region: SH3_3; cl17532 754252001436 Bacterial SH3 domain; Region: SH3_3; pfam08239 754252001437 Bacterial SH3 domain; Region: SH3_3; pfam08239 754252001438 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 754252001439 NlpC/P60 family; Region: NLPC_P60; pfam00877 754252001440 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 754252001441 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 754252001443 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754252001444 Walker A/P-loop; other site 754252001445 ATP binding site [chemical binding]; other site 754252001446 Q-loop/lid; other site 754252001447 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 754252001448 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 754252001449 Homeodomain-like domain; Region: HTH_32; pfam13565 754252001450 putative transposase OrfB; Reviewed; Region: PHA02517 754252001451 Integrase core domain; Region: rve; pfam00665 754252001452 Integrase core domain; Region: rve_3; pfam13683 754252001453 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 754252001454 dimerization interface [polypeptide binding]; other site 754252001455 putative DNA binding site [nucleotide binding]; other site 754252001456 putative Zn2+ binding site [ion binding]; other site 754252001457 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 754252001458 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 754252001459 Soluble P-type ATPase [General function prediction only]; Region: COG4087 754252001460 aminotransferase; Validated; Region: PRK07337 754252001461 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 754252001462 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754252001463 homodimer interface [polypeptide binding]; other site 754252001464 catalytic residue [active] 754252001465 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 754252001466 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 754252001467 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 754252001468 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 754252001469 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 754252001470 catalytic Zn binding site [ion binding]; other site 754252001471 NAD(P) binding site [chemical binding]; other site 754252001472 structural Zn binding site [ion binding]; other site 754252001473 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 754252001474 putative active site [active] 754252001475 transaldolase; Provisional; Region: PRK03903 754252001476 catalytic residue [active] 754252001477 PRC-barrel domain; Region: PRC; pfam05239 754252001478 Patatin-like phospholipase; Region: Patatin; pfam01734 754252001479 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 754252001480 active site 754252001481 nucleophile elbow; other site 754252001482 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 754252001483 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 754252001484 Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members...; Region: cytidine_deaminase-like; cl00269 754252001485 active site 754252001486 Zn binding site [ion binding]; other site 754252001487 PRC-barrel domain; Region: PRC; pfam05239 754252001488 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754252001489 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754252001490 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 754252001491 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 754252001492 UbiA prenyltransferase family; Region: UbiA; pfam01040 754252001493 RNase_H superfamily; Region: RNase_H_2; pfam13482 754252001494 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 754252001495 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754252001496 S-adenosylmethionine binding site [chemical binding]; other site 754252001497 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 754252001498 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754252001499 Walker A/P-loop; other site 754252001500 ATP binding site [chemical binding]; other site 754252001501 Q-loop/lid; other site 754252001502 ABC transporter signature motif; other site 754252001503 Walker B; other site 754252001504 D-loop; other site 754252001505 H-loop/switch region; other site 754252001506 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 754252001507 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 754252001508 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 754252001509 NADH dehydrogenase subunit A; Validated; Region: PRK07928 754252001510 NADH dehydrogenase subunit B; Validated; Region: PRK06411 754252001511 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 754252001512 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 754252001513 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 754252001514 NADH dehydrogenase subunit D; Validated; Region: PRK06075 754252001515 NADH dehydrogenase subunit E; Validated; Region: PRK07539 754252001516 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 754252001517 putative dimer interface [polypeptide binding]; other site 754252001518 [2Fe-2S] cluster binding site [ion binding]; other site 754252001519 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 754252001520 SLBB domain; Region: SLBB; pfam10531 754252001521 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 754252001522 NADH dehydrogenase subunit G; Validated; Region: PRK07860 754252001523 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 754252001524 catalytic loop [active] 754252001525 iron binding site [ion binding]; other site 754252001526 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 754252001527 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 754252001528 molybdopterin cofactor binding site; other site 754252001529 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 754252001530 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 754252001531 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 754252001532 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 754252001533 4Fe-4S binding domain; Region: Fer4; pfam00037 754252001534 4Fe-4S binding domain; Region: Fer4; pfam00037 754252001535 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 754252001536 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 754252001537 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 754252001538 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 754252001539 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 754252001540 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 754252001541 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 754252001542 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 754252001543 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 754252001544 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 754252001545 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 754252001546 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 754252001547 substrate binding pocket [chemical binding]; other site 754252001548 chain length determination region; other site 754252001549 substrate-Mg2+ binding site; other site 754252001550 catalytic residues [active] 754252001551 aspartate-rich region 1; other site 754252001552 active site lid residues [active] 754252001553 aspartate-rich region 2; other site 754252001554 Protein of unknown function (DUF805); Region: DUF805; pfam05656 754252001555 Protein of unknown function (DUF805); Region: DUF805; pfam05656 754252001556 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 754252001557 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 754252001558 active site 754252001559 Zn binding site [ion binding]; other site 754252001560 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 754252001561 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 754252001562 TPP-binding site [chemical binding]; other site 754252001563 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 754252001564 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 754252001565 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 754252001566 dimer interface [polypeptide binding]; other site 754252001567 PYR/PP interface [polypeptide binding]; other site 754252001568 TPP binding site [chemical binding]; other site 754252001569 substrate binding site [chemical binding]; other site 754252001570 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 754252001571 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 754252001572 putative catalytic site [active] 754252001573 putative metal binding site [ion binding]; other site 754252001574 putative phosphate binding site [ion binding]; other site 754252001575 peroxiredoxin; Region: AhpC; TIGR03137 754252001576 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 754252001577 dimer interface [polypeptide binding]; other site 754252001578 decamer (pentamer of dimers) interface [polypeptide binding]; other site 754252001579 catalytic triad [active] 754252001580 peroxidatic and resolving cysteines [active] 754252001581 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 754252001582 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 754252001583 catalytic residue [active] 754252001584 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 754252001585 catalytic residues [active] 754252001586 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 754252001587 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 754252001588 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 754252001589 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 754252001590 active site 754252001591 catalytic site [active] 754252001592 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 754252001593 active site 2 [active] 754252001594 active site 1 [active] 754252001595 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 754252001596 FAD binding domain; Region: FAD_binding_4; pfam01565 754252001597 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 754252001598 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 754252001599 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 754252001600 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 754252001601 putative homodimer interface [polypeptide binding]; other site 754252001602 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 754252001603 heterodimer interface [polypeptide binding]; other site 754252001604 homodimer interface [polypeptide binding]; other site 754252001605 Ribosomal protein L11/L12; Region: RL11; smart00649 754252001606 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 754252001607 putative thiostrepton binding site; other site 754252001608 23S rRNA interface [nucleotide binding]; other site 754252001609 L7/L12 interface [polypeptide binding]; other site 754252001610 L25 interface [polypeptide binding]; other site 754252001611 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 754252001612 mRNA/rRNA interface [nucleotide binding]; other site 754252001613 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 754252001614 lipoyl synthase; Provisional; Region: PRK05481 754252001615 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 754252001616 FeS/SAM binding site; other site 754252001617 putative transposase OrfB; Reviewed; Region: PHA02517 754252001618 HTH-like domain; Region: HTH_21; pfam13276 754252001619 Integrase core domain; Region: rve; pfam00665 754252001620 Integrase core domain; Region: rve_3; cl15866 754252001621 Transposase; Region: HTH_Tnp_1; cl17663 754252001622 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 754252001623 23S rRNA interface [nucleotide binding]; other site 754252001624 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 754252001625 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 754252001626 core dimer interface [polypeptide binding]; other site 754252001627 peripheral dimer interface [polypeptide binding]; other site 754252001628 L10 interface [polypeptide binding]; other site 754252001629 L11 interface [polypeptide binding]; other site 754252001630 putative EF-Tu interaction site [polypeptide binding]; other site 754252001631 putative EF-G interaction site [polypeptide binding]; other site 754252001632 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 754252001633 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 754252001634 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 754252001635 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 754252001636 RPB1 interaction site [polypeptide binding]; other site 754252001637 RPB10 interaction site [polypeptide binding]; other site 754252001638 RPB11 interaction site [polypeptide binding]; other site 754252001639 RPB3 interaction site [polypeptide binding]; other site 754252001640 RPB12 interaction site [polypeptide binding]; other site 754252001641 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 754252001642 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 754252001643 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 754252001644 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 754252001645 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 754252001646 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 754252001647 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 754252001648 G-loop; other site 754252001649 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 754252001650 DNA binding site [nucleotide binding] 754252001651 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 754252001652 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 754252001653 S17 interaction site [polypeptide binding]; other site 754252001654 S8 interaction site; other site 754252001655 16S rRNA interaction site [nucleotide binding]; other site 754252001656 streptomycin interaction site [chemical binding]; other site 754252001657 23S rRNA interaction site [nucleotide binding]; other site 754252001658 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 754252001659 30S ribosomal protein S7; Validated; Region: PRK05302 754252001660 elongation factor G; Reviewed; Region: PRK00007 754252001661 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 754252001662 G1 box; other site 754252001663 putative GEF interaction site [polypeptide binding]; other site 754252001664 GTP/Mg2+ binding site [chemical binding]; other site 754252001665 Switch I region; other site 754252001666 G2 box; other site 754252001667 G3 box; other site 754252001668 Switch II region; other site 754252001669 G4 box; other site 754252001670 G5 box; other site 754252001671 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 754252001672 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 754252001673 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 754252001674 elongation factor Tu; Reviewed; Region: PRK00049 754252001675 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 754252001676 G1 box; other site 754252001677 GEF interaction site [polypeptide binding]; other site 754252001678 GTP/Mg2+ binding site [chemical binding]; other site 754252001679 Switch I region; other site 754252001680 G2 box; other site 754252001681 G3 box; other site 754252001682 Switch II region; other site 754252001683 G4 box; other site 754252001684 G5 box; other site 754252001685 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 754252001686 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 754252001687 Antibiotic Binding Site [chemical binding]; other site 754252001688 Predicted membrane protein [Function unknown]; Region: COG3463 754252001689 Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852 754252001690 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 754252001691 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 754252001692 Coenzyme A binding pocket [chemical binding]; other site 754252001693 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 754252001694 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 754252001695 HIGH motif; other site 754252001696 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 754252001697 active site 754252001698 KMSKS motif; other site 754252001699 Homeodomain-like domain; Region: HTH_23; cl17451 754252001700 Winged helix-turn helix; Region: HTH_29; pfam13551 754252001701 Integrase core domain; Region: rve; pfam00665 754252001702 Integrase core domain; Region: rve_3; pfam13683 754252001703 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 754252001704 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 754252001705 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754252001706 catalytic residue [active] 754252001707 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 754252001708 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 754252001709 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 754252001710 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 754252001711 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 754252001712 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 754252001713 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 754252001714 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 754252001715 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 754252001716 putative translocon binding site; other site 754252001717 protein-rRNA interface [nucleotide binding]; other site 754252001718 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 754252001719 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 754252001720 G-X-X-G motif; other site 754252001721 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 754252001722 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 754252001723 23S rRNA interface [nucleotide binding]; other site 754252001724 5S rRNA interface [nucleotide binding]; other site 754252001725 putative antibiotic binding site [chemical binding]; other site 754252001726 L25 interface [polypeptide binding]; other site 754252001727 L27 interface [polypeptide binding]; other site 754252001728 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 754252001729 23S rRNA interface [nucleotide binding]; other site 754252001730 putative translocon interaction site; other site 754252001731 signal recognition particle (SRP54) interaction site; other site 754252001732 L23 interface [polypeptide binding]; other site 754252001733 trigger factor interaction site; other site 754252001734 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 754252001735 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 754252001736 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 754252001737 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 754252001738 RNA binding site [nucleotide binding]; other site 754252001739 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 754252001740 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 754252001741 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 754252001742 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 754252001743 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 754252001744 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 754252001745 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 754252001746 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 754252001747 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 754252001748 5S rRNA interface [nucleotide binding]; other site 754252001749 L27 interface [polypeptide binding]; other site 754252001750 23S rRNA interface [nucleotide binding]; other site 754252001751 L5 interface [polypeptide binding]; other site 754252001752 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 754252001753 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 754252001754 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 754252001755 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 754252001756 23S rRNA binding site [nucleotide binding]; other site 754252001757 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 754252001758 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 754252001759 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 754252001760 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 754252001761 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 754252001762 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 754252001763 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 754252001764 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 754252001765 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 754252001766 Walker A/P-loop; other site 754252001767 ATP binding site [chemical binding]; other site 754252001768 Q-loop/lid; other site 754252001769 ABC transporter signature motif; other site 754252001770 Walker B; other site 754252001771 D-loop; other site 754252001772 H-loop/switch region; other site 754252001773 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 754252001774 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 754252001775 Walker A/P-loop; other site 754252001776 ATP binding site [chemical binding]; other site 754252001777 Q-loop/lid; other site 754252001778 ABC transporter signature motif; other site 754252001779 Walker B; other site 754252001780 D-loop; other site 754252001781 H-loop/switch region; other site 754252001782 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 754252001783 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 754252001784 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754252001785 dimer interface [polypeptide binding]; other site 754252001786 conserved gate region; other site 754252001787 putative PBP binding loops; other site 754252001788 ABC-ATPase subunit interface; other site 754252001789 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 754252001790 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754252001791 dimer interface [polypeptide binding]; other site 754252001792 conserved gate region; other site 754252001793 putative PBP binding loops; other site 754252001794 ABC-ATPase subunit interface; other site 754252001795 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 754252001796 SecY translocase; Region: SecY; pfam00344 754252001797 adenylate kinase; Reviewed; Region: adk; PRK00279 754252001798 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 754252001799 AMP-binding site [chemical binding]; other site 754252001800 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 754252001801 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 754252001802 active site 754252001803 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 754252001804 YCII-related domain; Region: YCII; cl00999 754252001805 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 754252001806 rRNA binding site [nucleotide binding]; other site 754252001807 predicted 30S ribosome binding site; other site 754252001808 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 754252001809 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 754252001810 30S ribosomal protein S13; Region: bact_S13; TIGR03631 754252001811 30S ribosomal protein S11; Validated; Region: PRK05309 754252001812 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 754252001813 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 754252001814 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 754252001815 RNA binding surface [nucleotide binding]; other site 754252001816 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 754252001817 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 754252001818 alphaNTD homodimer interface [polypeptide binding]; other site 754252001819 alphaNTD - beta interaction site [polypeptide binding]; other site 754252001820 alphaNTD - beta' interaction site [polypeptide binding]; other site 754252001821 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 754252001822 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 754252001823 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 754252001824 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 754252001825 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 754252001826 Domain of unknown function (DUF348); Region: DUF348; pfam03990 754252001827 Domain of unknown function (DUF348); Region: DUF348; pfam03990 754252001828 Domain of unknown function (DUF348); Region: DUF348; pfam03990 754252001829 G5 domain; Region: G5; pfam07501 754252001830 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 754252001831 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 754252001832 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 754252001833 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 754252001834 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 754252001835 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 754252001836 Walker A/P-loop; other site 754252001837 ATP binding site [chemical binding]; other site 754252001838 Q-loop/lid; other site 754252001839 ABC transporter signature motif; other site 754252001840 Walker B; other site 754252001841 D-loop; other site 754252001842 H-loop/switch region; other site 754252001843 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 754252001844 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 754252001845 Walker A/P-loop; other site 754252001846 ATP binding site [chemical binding]; other site 754252001847 Q-loop/lid; other site 754252001848 ABC transporter signature motif; other site 754252001849 Walker B; other site 754252001850 D-loop; other site 754252001851 H-loop/switch region; other site 754252001852 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 754252001853 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754252001854 Walker A/P-loop; other site 754252001855 ATP binding site [chemical binding]; other site 754252001856 Q-loop/lid; other site 754252001857 ABC transporter signature motif; other site 754252001858 Walker B; other site 754252001859 D-loop; other site 754252001860 H-loop/switch region; other site 754252001861 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754252001862 S-adenosylmethionine binding site [chemical binding]; other site 754252001863 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 754252001864 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 754252001865 dimerization interface 3.5A [polypeptide binding]; other site 754252001866 active site 754252001867 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 754252001868 hypothetical protein; Provisional; Region: PRK11770 754252001869 Domain of unknown function (DUF307); Region: DUF307; pfam03733 754252001870 Domain of unknown function (DUF307); Region: DUF307; pfam03733 754252001871 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 754252001872 elongation factor G; Reviewed; Region: PRK12740 754252001873 G1 box; other site 754252001874 GTP/Mg2+ binding site [chemical binding]; other site 754252001875 G2 box; other site 754252001876 Switch I region; other site 754252001877 G3 box; other site 754252001878 Switch II region; other site 754252001879 G4 box; other site 754252001880 G5 box; other site 754252001881 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 754252001882 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 754252001883 Elongation factor G C-terminus. This domain includes the carboxyl terminal regions of elongation factors (EFs) bacterial EF-G, eukaryotic and archeal EF-2 and eukaryotic mitochondrial mtEFG1s and mtEFG2s. This group also includes proteins similar to the...; Region: Elongation_Factor_C; cd01514 754252001884 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 754252001885 23S rRNA interface [nucleotide binding]; other site 754252001886 L3 interface [polypeptide binding]; other site 754252001887 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 754252001888 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 754252001889 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 754252001890 active site 754252001891 substrate binding site [chemical binding]; other site 754252001892 metal binding site [ion binding]; metal-binding site 754252001893 pantothenate kinase; Provisional; Region: PRK05439 754252001894 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 754252001895 CoA-binding site [chemical binding]; other site 754252001896 Mg2+-binding site [ion binding]; other site 754252001897 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 754252001898 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 754252001899 glutaminase active site [active] 754252001900 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 754252001901 dimer interface [polypeptide binding]; other site 754252001902 active site 754252001903 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 754252001904 dimer interface [polypeptide binding]; other site 754252001905 active site 754252001906 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 754252001907 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 754252001908 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 754252001909 putative substrate binding site [chemical binding]; other site 754252001910 putative ATP binding site [chemical binding]; other site 754252001911 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 754252001912 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 754252001913 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 754252001914 DEAD-like helicases superfamily; Region: DEXDc; smart00487 754252001915 ATP binding site [chemical binding]; other site 754252001916 Mg++ binding site [ion binding]; other site 754252001917 motif III; other site 754252001918 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 754252001919 nucleotide binding region [chemical binding]; other site 754252001920 ATP-binding site [chemical binding]; other site 754252001921 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 754252001922 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 754252001923 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 754252001924 Glycoprotease family; Region: Peptidase_M22; pfam00814 754252001925 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 754252001926 UGMP family protein; Validated; Region: PRK09604 754252001927 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 754252001928 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 754252001929 putative FMN binding site [chemical binding]; other site 754252001930 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 754252001931 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 754252001932 putative dimer interface [polypeptide binding]; other site 754252001933 active site pocket [active] 754252001934 putative cataytic base [active] 754252001935 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 754252001936 trimer interface [polypeptide binding]; other site 754252001937 active site 754252001938 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 754252001939 putative active site [active] 754252001940 nucleotide binding site [chemical binding]; other site 754252001941 nudix motif; other site 754252001942 putative metal binding site [ion binding]; other site 754252001943 H+ Antiporter protein; Region: 2A0121; TIGR00900 754252001944 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754252001945 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754252001946 putative PBP binding loops; other site 754252001947 ABC-ATPase subunit interface; other site 754252001948 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 754252001949 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 754252001950 Walker A/P-loop; other site 754252001951 ATP binding site [chemical binding]; other site 754252001952 Q-loop/lid; other site 754252001953 ABC transporter signature motif; other site 754252001954 Walker B; other site 754252001955 D-loop; other site 754252001956 H-loop/switch region; other site 754252001957 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754252001958 ABC-ATPase subunit interface; other site 754252001959 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 754252001960 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 754252001961 oligomerisation interface [polypeptide binding]; other site 754252001962 mobile loop; other site 754252001963 roof hairpin; other site 754252001964 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 754252001965 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 754252001966 ring oligomerisation interface [polypeptide binding]; other site 754252001967 ATP/Mg binding site [chemical binding]; other site 754252001968 stacking interactions; other site 754252001969 hinge regions; other site 754252001970 Homeodomain-like domain; Region: HTH_23; cl17451 754252001971 Winged helix-turn helix; Region: HTH_29; pfam13551 754252001972 Integrase core domain; Region: rve; pfam00665 754252001973 Integrase core domain; Region: rve_3; pfam13683 754252001974 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 754252001975 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 754252001976 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 754252001977 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 754252001978 active site 754252001979 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 754252001980 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 754252001981 active site 754252001982 chorismate mutase; Provisional; Region: PRK09239 754252001983 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 754252001984 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cl02713 754252001985 active site 754252001986 metal binding site [ion binding]; metal-binding site 754252001987 serine O-acetyltransferase; Region: cysE; TIGR01172 754252001988 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 754252001989 trimer interface [polypeptide binding]; other site 754252001990 active site 754252001991 substrate binding site [chemical binding]; other site 754252001992 CoA binding site [chemical binding]; other site 754252001993 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 754252001994 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 754252001995 dimer interface [polypeptide binding]; other site 754252001996 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754252001997 catalytic residue [active] 754252001998 Ribulose kinase (Energy production and conversion).ATP + L(or D)-ribulose = ADP + L(or D)-ribulose 5-phosphate. carbohydrate degradation; L-arabinose degradation via L-ribulose; D-xylulose 5-phosphate from L-arabinose (bacteria route): step 2/3. Belongs to the ribulokinase family. 754252001999 ATP + L(or D)-ribulose = ADP + L(or D)-ribulose 5-phosphate. L-arabinose catabolism; second step. transcription is repressed by glucose and by the binding of araR to the operon promoter. L-arabinose acts as an inducer by inhibiting the binding of araR to the DNA, thus allowing expression of the gene. Belongs to the ribulokinase family. 754252002000 L-ribulose-5-phosphate 4-epimerase; Validated; Region: PRK06557 754252002001 intersubunit interface [polypeptide binding]; other site 754252002002 active site 754252002003 Zn2+ binding site [ion binding]; other site 754252002004 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 754252002005 L-arabinose isomerase; Provisional; Region: PRK02929 754252002006 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 754252002007 hexamer (dimer of trimers) interface [polypeptide binding]; other site 754252002008 trimer interface [polypeptide binding]; other site 754252002009 substrate binding site [chemical binding]; other site 754252002010 Mn binding site [ion binding]; other site 754252002011 Transcriptional regulators [Transcription]; Region: PurR; COG1609 754252002012 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 754252002013 DNA binding site [nucleotide binding] 754252002014 domain linker motif; other site 754252002015 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 754252002016 ligand binding site [chemical binding]; other site 754252002017 dimerization interface (open form) [polypeptide binding]; other site 754252002018 dimerization interface (closed form) [polypeptide binding]; other site 754252002019 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 754252002020 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 754252002021 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 754252002022 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 754252002023 Walker A/P-loop; other site 754252002024 ATP binding site [chemical binding]; other site 754252002025 Q-loop/lid; other site 754252002026 ABC transporter signature motif; other site 754252002027 Walker B; other site 754252002028 D-loop; other site 754252002029 H-loop/switch region; other site 754252002030 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 754252002032 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 754252002033 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 754252002034 TM-ABC transporter signature motif; other site 754252002035 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 754252002036 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 754252002037 TM-ABC transporter signature motif; other site 754252002038 GMP synthase; Reviewed; Region: guaA; PRK00074 754252002039 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 754252002040 AMP/PPi binding site [chemical binding]; other site 754252002041 candidate oxyanion hole; other site 754252002042 catalytic triad [active] 754252002043 potential glutamine specificity residues [chemical binding]; other site 754252002044 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 754252002045 ATP Binding subdomain [chemical binding]; other site 754252002046 Ligand Binding sites [chemical binding]; other site 754252002047 Dimerization subdomain; other site 754252002048 Domain of unknown function (DUF1963); Region: DUF1963; pfam09234 754252002049 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 754252002050 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 754252002051 NAD(P) binding site [chemical binding]; other site 754252002052 PspC domain; Region: PspC; pfam04024 754252002053 PspC domain; Region: PspC; pfam04024 754252002054 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 754252002055 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 754252002056 ATP binding site [chemical binding]; other site 754252002057 Mg2+ binding site [ion binding]; other site 754252002058 G-X-G motif; other site 754252002059 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 754252002060 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754252002061 active site 754252002062 phosphorylation site [posttranslational modification] 754252002063 intermolecular recognition site; other site 754252002064 dimerization interface [polypeptide binding]; other site 754252002065 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 754252002066 DNA binding residues [nucleotide binding] 754252002067 dimerization interface [polypeptide binding]; other site 754252002068 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 754252002069 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 754252002070 intersubunit interface [polypeptide binding]; other site 754252002071 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 754252002072 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 754252002073 ABC-ATPase subunit interface; other site 754252002074 dimer interface [polypeptide binding]; other site 754252002075 putative PBP binding regions; other site 754252002076 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 754252002077 ABC-ATPase subunit interface; other site 754252002078 dimer interface [polypeptide binding]; other site 754252002079 putative PBP binding regions; other site 754252002080 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 754252002081 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 754252002082 Walker A/P-loop; other site 754252002083 ATP binding site [chemical binding]; other site 754252002084 Q-loop/lid; other site 754252002085 ABC transporter signature motif; other site 754252002086 Walker B; other site 754252002087 D-loop; other site 754252002088 H-loop/switch region; other site 754252002089 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 754252002090 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 754252002091 putative active site [active] 754252002092 catalytic site [active] 754252002093 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 754252002094 putative active site [active] 754252002095 catalytic site [active] 754252002096 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 754252002097 Part of AAA domain; Region: AAA_19; pfam13245 754252002098 Family description; Region: UvrD_C_2; pfam13538 754252002099 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 754252002100 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 754252002101 active site 754252002102 cosubstrate binding site; other site 754252002103 substrate binding site [chemical binding]; other site 754252002104 catalytic site [active] 754252002105 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 754252002106 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 754252002107 purine monophosphate binding site [chemical binding]; other site 754252002108 dimer interface [polypeptide binding]; other site 754252002109 putative catalytic residues [active] 754252002110 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 754252002111 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 754252002112 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 754252002113 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 754252002114 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 754252002115 homodimer interface [polypeptide binding]; other site 754252002116 NADP binding site [chemical binding]; other site 754252002117 substrate binding site [chemical binding]; other site 754252002118 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 754252002119 malate dehydrogenase; Provisional; Region: PRK05442 754252002120 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 754252002121 NAD(P) binding site [chemical binding]; other site 754252002122 dimer interface [polypeptide binding]; other site 754252002123 malate binding site [chemical binding]; other site 754252002124 isocitrate dehydrogenase; Validated; Region: PRK08299 754252002125 AzlC protein; Region: AzlC; cl00570 754252002126 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 754252002127 Domain of unknown function DUF21; Region: DUF21; pfam01595 754252002128 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 754252002129 Transporter associated domain; Region: CorC_HlyC; smart01091 754252002130 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 754252002131 substrate binding site [chemical binding]; other site 754252002132 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 754252002133 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 754252002134 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 754252002135 RNA/DNA hybrid binding site [nucleotide binding]; other site 754252002136 active site 754252002137 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 754252002138 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 754252002139 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 754252002140 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 754252002141 substrate binding site [chemical binding]; other site 754252002142 oxyanion hole (OAH) forming residues; other site 754252002143 trimer interface [polypeptide binding]; other site 754252002144 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 754252002145 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 754252002146 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 754252002147 active site 754252002148 KMSKS motif; other site 754252002149 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 754252002150 tRNA binding surface [nucleotide binding]; other site 754252002151 anticodon binding site; other site 754252002152 NAD-dependent deacetylase; Provisional; Region: PRK00481 754252002153 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 754252002154 Predicted membrane protein [Function unknown]; Region: COG2323 754252002155 Protein of unknown function (DUF3290); Region: DUF3290; pfam11694 754252002156 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 754252002157 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 754252002158 DNA binding residues [nucleotide binding] 754252002159 putative dimer interface [polypeptide binding]; other site 754252002160 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 754252002161 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 754252002162 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 754252002163 Coenzyme A binding pocket [chemical binding]; other site 754252002164 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 754252002165 6-hydroxycyclohex-1-ene-1-carboxyl-CoA dehydrogenase, N-benzyl-3-pyrrolidinol dehydrogenase, and other MDR family members; Region: hydroxyacyl_CoA_DH; cd08254 754252002166 putative NAD(P) binding site [chemical binding]; other site 754252002167 catalytic Zn binding site [ion binding]; other site 754252002168 structural Zn binding site [ion binding]; other site 754252002169 TIGR04222 domain; Region: near_uncomplex 754252002170 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 754252002171 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 754252002172 dimer interface [polypeptide binding]; other site 754252002173 PYR/PP interface [polypeptide binding]; other site 754252002174 TPP binding site [chemical binding]; other site 754252002175 substrate binding site [chemical binding]; other site 754252002176 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 754252002177 Domain of unknown function; Region: EKR; smart00890 754252002178 4Fe-4S binding domain; Region: Fer4_6; pfam12837 754252002179 4Fe-4S binding domain; Region: Fer4; pfam00037 754252002180 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 754252002181 TPP-binding site [chemical binding]; other site 754252002182 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565 754252002183 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 754252002184 phosphate binding site [ion binding]; other site 754252002185 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 754252002186 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 754252002187 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 754252002188 ATP-grasp domain; Region: ATP-grasp_4; cl17255 754252002189 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 754252002190 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 754252002191 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 754252002192 carboxyltransferase (CT) interaction site; other site 754252002193 biotinylation site [posttranslational modification]; other site 754252002194 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 754252002195 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 754252002196 putative DNA binding site [nucleotide binding]; other site 754252002197 catalytic residue [active] 754252002198 putative H2TH interface [polypeptide binding]; other site 754252002199 putative catalytic residues [active] 754252002200 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 754252002201 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 754252002202 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 754252002203 nudix motif; other site 754252002204 Maf-like protein; Region: Maf; pfam02545 754252002205 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 754252002206 active site 754252002207 dimer interface [polypeptide binding]; other site 754252002208 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 754252002209 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 754252002210 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 754252002211 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 754252002212 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 754252002213 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 754252002214 C-term region 754252002215 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 754252002216 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 754252002217 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 754252002218 Walker A/P-loop; other site 754252002219 ATP binding site [chemical binding]; other site 754252002220 Q-loop/lid; other site 754252002221 ABC transporter signature motif; other site 754252002222 Walker B; other site 754252002223 D-loop; other site 754252002224 H-loop/switch region; other site 754252002225 Predicted transcriptional regulators [Transcription]; Region: COG1510 754252002226 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 754252002227 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 754252002228 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 754252002229 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 754252002230 Bacterial PH domain; Region: DUF304; pfam03703 754252002231 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 754252002232 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 754252002233 chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I...; Region: chaperonin_like; cl02777 754252002234 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 754252002235 active site pocket [active] 754252002236 oxyanion hole [active] 754252002237 catalytic triad [active] 754252002238 active site nucleophile [active] 754252002239 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 754252002240 ATP-grasp domain; Region: ATP-grasp; pfam02222 754252002241 AIR carboxylase; Region: AIRC; pfam00731 754252002242 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 754252002243 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 754252002244 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 754252002245 Substrate binding site; other site 754252002246 Transcription factor WhiB; Region: Whib; pfam02467 754252002247 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 754252002248 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 754252002249 active site 754252002250 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 754252002251 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 754252002252 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 754252002253 Eukaryotic phosphomannomutase; Region: PMM; cl17107 754252002254 Uncharacterized conserved protein [Function unknown]; Region: COG2835 754252002255 bifunctional phosphoglucose/phosphomannose isomerase; Validated; Region: PRK08674 754252002256 Cation efflux family; Region: Cation_efflux; pfam01545 754252002257 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 754252002258 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754252002259 putative substrate translocation pore; other site 754252002260 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754252002261 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 754252002262 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 754252002263 RDD family; Region: RDD; pfam06271 754252002264 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 754252002265 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 754252002266 O-succinylbenzoate synthase; Provisional; Region: PRK02901 754252002267 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 754252002268 active site 754252002269 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 754252002270 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 754252002271 PYR/PP interface [polypeptide binding]; other site 754252002272 dimer interface [polypeptide binding]; other site 754252002273 TPP binding site [chemical binding]; other site 754252002274 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 754252002275 TPP-binding site; other site 754252002276 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754252002277 Walker A/P-loop; other site 754252002278 ATP binding site [chemical binding]; other site 754252002279 Q-loop/lid; other site 754252002280 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 754252002281 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754252002282 ABC transporter signature motif; other site 754252002283 Walker B; other site 754252002284 D-loop; other site 754252002285 H-loop/switch region; other site 754252002286 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754252002287 Walker A/P-loop; other site 754252002288 ATP binding site [chemical binding]; other site 754252002289 Q-loop/lid; other site 754252002290 ABC transporter signature motif; other site 754252002291 Walker B; other site 754252002292 D-loop; other site 754252002293 H-loop/switch region; other site 754252002294 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 754252002295 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 754252002296 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 754252002297 acyl-activating enzyme (AAE) consensus motif; other site 754252002298 AMP binding site [chemical binding]; other site 754252002299 active site 754252002300 CoA binding site [chemical binding]; other site 754252002301 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 754252002302 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 754252002303 substrate binding site [chemical binding]; other site 754252002304 oxyanion hole (OAH) forming residues; other site 754252002305 trimer interface [polypeptide binding]; other site 754252002306 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 754252002307 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 754252002308 active site 754252002309 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 754252002310 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 754252002311 glutamate racemase; Provisional; Region: PRK00865 754252002312 ribonuclease PH; Reviewed; Region: rph; PRK00173 754252002313 Ribonuclease PH; Region: RNase_PH_bact; cd11362 754252002314 hexamer interface [polypeptide binding]; other site 754252002315 active site 754252002316 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 754252002317 active site 754252002318 dimerization interface [polypeptide binding]; other site 754252002319 thymidylate synthase; Reviewed; Region: thyA; PRK01827 754252002320 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 754252002321 dimerization interface [polypeptide binding]; other site 754252002322 active site 754252002323 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 754252002324 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 754252002325 folate binding site [chemical binding]; other site 754252002326 NADP+ binding site [chemical binding]; other site 754252002327 DNA polymerase IV; Provisional; Region: PRK03348 754252002328 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 754252002329 active site 754252002330 DNA binding site [nucleotide binding] 754252002331 membrane ATPase/protein kinase; Provisional; Region: PRK09435 754252002332 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 754252002333 Walker A; other site 754252002334 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 754252002335 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 754252002336 active site 754252002337 substrate binding site [chemical binding]; other site 754252002338 coenzyme B12 binding site [chemical binding]; other site 754252002339 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 754252002340 B12 binding site [chemical binding]; other site 754252002341 cobalt ligand [ion binding]; other site 754252002342 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 754252002343 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 754252002344 heterodimer interface [polypeptide binding]; other site 754252002345 substrate interaction site [chemical binding]; other site 754252002346 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 754252002347 active site 754252002348 SAM binding site [chemical binding]; other site 754252002349 homodimer interface [polypeptide binding]; other site 754252002350 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 754252002351 active site 754252002352 SAM binding site [chemical binding]; other site 754252002353 homodimer interface [polypeptide binding]; other site 754252002354 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 754252002355 putative homodimer interface [polypeptide binding]; other site 754252002356 active site 754252002357 SAM binding site [chemical binding]; other site 754252002358 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 754252002359 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 754252002360 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 754252002361 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 754252002362 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 754252002363 active site 754252002364 SAM binding site [chemical binding]; other site 754252002365 homodimer interface [polypeptide binding]; other site 754252002366 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 754252002367 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 754252002368 putative active site [active] 754252002369 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 754252002370 putative active site [active] 754252002371 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 754252002372 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 754252002373 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 754252002374 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 754252002375 Precorrin-8X methylmutase; Region: CbiC; pfam02570 754252002376 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 754252002377 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754252002378 S-adenosylmethionine binding site [chemical binding]; other site 754252002379 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 754252002380 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 754252002381 L-ribulose-5-phosphate 4-epimerase; Validated; Region: PRK06557 754252002382 intersubunit interface [polypeptide binding]; other site 754252002383 active site 754252002384 Zn2+ binding site [ion binding]; other site 754252002385 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 754252002386 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 754252002387 catalytic triad [active] 754252002388 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 754252002389 oligomerisation interface [polypeptide binding]; other site 754252002390 mobile loop; other site 754252002391 roof hairpin; other site 754252002392 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 754252002393 catalytic triad [active] 754252002394 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 754252002395 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 754252002396 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 754252002397 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 754252002398 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754252002399 Walker A/P-loop; other site 754252002400 ATP binding site [chemical binding]; other site 754252002401 Q-loop/lid; other site 754252002402 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 754252002403 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 754252002404 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754252002405 Walker A/P-loop; other site 754252002406 ATP binding site [chemical binding]; other site 754252002407 Q-loop/lid; other site 754252002408 ABC transporter signature motif; other site 754252002409 Walker B; other site 754252002410 D-loop; other site 754252002411 H-loop/switch region; other site 754252002412 HD domain; Region: HD_4; pfam13328 754252002413 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 754252002414 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 754252002415 catalytic site [active] 754252002416 putative active site [active] 754252002417 putative substrate binding site [chemical binding]; other site 754252002418 dimer interface [polypeptide binding]; other site 754252002419 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754252002420 Major Facilitator Superfamily; Region: MFS_1; pfam07690 754252002421 putative substrate translocation pore; other site 754252002422 Protease prsW family; Region: PrsW-protease; pfam13367 754252002423 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 754252002424 G1 box; other site 754252002425 GTP/Mg2+ binding site [chemical binding]; other site 754252002426 G2 box; other site 754252002427 Switch I region; other site 754252002428 G3 box; other site 754252002429 Switch II region; other site 754252002430 G4 box; other site 754252002431 YfjP GTPase; Region: YfjP; cd11383 754252002432 G1 box; other site 754252002433 GTP/Mg2+ binding site [chemical binding]; other site 754252002434 Switch I region; other site 754252002435 G2 box; other site 754252002436 Switch II region; other site 754252002437 G3 box; other site 754252002438 G4 box; other site 754252002439 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 754252002440 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 754252002441 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 754252002442 ssDNA binding site [nucleotide binding]; other site 754252002443 dimer interface [polypeptide binding]; other site 754252002444 tetramer (dimer of dimers) interface [polypeptide binding]; other site 754252002445 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 754252002446 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754252002447 Walker A/P-loop; other site 754252002448 ATP binding site [chemical binding]; other site 754252002449 Q-loop/lid; other site 754252002450 ABC transporter signature motif; other site 754252002451 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 754252002452 ABC transporter; Region: ABC_tran_2; pfam12848 754252002453 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 754252002454 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 754252002455 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 754252002456 DAK2 domain; Region: Dak2; cl03685 754252002457 dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377 754252002458 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 754252002459 active site 754252002460 active pocket/dimerization site; other site 754252002461 phosphorylation site [posttranslational modification] 754252002462 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 754252002463 dimerization domain swap beta strand [polypeptide binding]; other site 754252002464 regulatory protein interface [polypeptide binding]; other site 754252002465 active site 754252002466 regulatory phosphorylation site [posttranslational modification]; other site 754252002467 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 754252002468 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 754252002469 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 754252002470 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 754252002471 nucleotide binding site/active site [active] 754252002472 HIT family signature motif; other site 754252002473 catalytic residue [active] 754252002474 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 754252002475 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 754252002476 active site 754252002477 Zn binding site [ion binding]; other site 754252002478 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 754252002479 FAD binding domain; Region: FAD_binding_4; pfam01565 754252002480 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 754252002481 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 754252002482 MarR family; Region: MarR; pfam01047 754252002483 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 754252002484 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 754252002485 acyl-activating enzyme (AAE) consensus motif; other site 754252002486 putative AMP binding site [chemical binding]; other site 754252002487 putative active site [active] 754252002488 putative CoA binding site [chemical binding]; other site 754252002489 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 754252002490 active site 754252002491 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 754252002492 active site 754252002493 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 754252002494 dimer interface [polypeptide binding]; other site 754252002495 substrate binding site [chemical binding]; other site 754252002496 ATP binding site [chemical binding]; other site 754252002497 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 754252002498 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 754252002499 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 754252002500 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 754252002501 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 754252002502 Zn binding site [ion binding]; other site 754252002503 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 754252002504 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 754252002505 Nuclease-related domain; Region: NERD; pfam08378 754252002506 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 754252002507 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 754252002508 nucleotide binding pocket [chemical binding]; other site 754252002509 K-X-D-G motif; other site 754252002510 catalytic site [active] 754252002511 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 754252002512 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 754252002513 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 754252002514 Dimer interface [polypeptide binding]; other site 754252002515 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 754252002516 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 754252002517 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 754252002520 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 754252002521 trigger factor; Provisional; Region: tig; PRK01490 754252002522 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 754252002523 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 754252002524 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 754252002525 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 754252002526 Domain of unknown function DUF20; Region: UPF0118; pfam01594 754252002527 Clp protease; Region: CLP_protease; pfam00574 754252002528 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 754252002529 oligomer interface [polypeptide binding]; other site 754252002530 active site residues [active] 754252002531 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 754252002532 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 754252002533 oligomer interface [polypeptide binding]; other site 754252002534 active site residues [active] 754252002535 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 754252002536 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 754252002537 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 754252002538 Walker A motif; other site 754252002539 ATP binding site [chemical binding]; other site 754252002540 Walker B motif; other site 754252002541 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 754252002542 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 754252002543 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 754252002544 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754252002545 catalytic residue [active] 754252002546 6-phosphofructokinase; Provisional; Region: PRK03202 754252002547 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 754252002548 active site 754252002549 ADP/pyrophosphate binding site [chemical binding]; other site 754252002550 dimerization interface [polypeptide binding]; other site 754252002551 allosteric effector site; other site 754252002552 fructose-1,6-bisphosphate binding site; other site 754252002553 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 754252002554 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 754252002555 motif II; other site 754252002556 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208 754252002557 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 754252002558 active site 754252002559 HIGH motif; other site 754252002560 nucleotide binding site [chemical binding]; other site 754252002561 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 754252002562 active site 754252002563 KMSKS motif; other site 754252002564 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 754252002565 tRNA binding surface [nucleotide binding]; other site 754252002566 anticodon binding site; other site 754252002567 Thioredoxin; Region: Thioredoxin_4; cl17273 754252002568 Thioredoxin; Region: Thioredoxin_4; cl17273 754252002569 Predicted membrane protein [Function unknown]; Region: COG2259 754252002570 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 754252002571 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 754252002572 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 754252002573 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 754252002574 active site 754252002575 multimer interface [polypeptide binding]; other site 754252002576 CAAX protease self-immunity; Region: Abi; pfam02517 754252002577 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 754252002578 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 754252002579 B12 binding site [chemical binding]; other site 754252002580 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 754252002581 FeS/SAM binding site; other site 754252002582 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 754252002583 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 754252002584 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 754252002585 MarR family; Region: MarR_2; pfam12802 754252002586 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 754252002587 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105 754252002588 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 754252002589 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 754252002590 homodimer interface [polypeptide binding]; other site 754252002591 oligonucleotide binding site [chemical binding]; other site 754252002592 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 754252002593 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 754252002594 GTPase CgtA; Reviewed; Region: obgE; PRK12296 754252002595 GTP1/OBG; Region: GTP1_OBG; pfam01018 754252002596 Obg GTPase; Region: Obg; cd01898 754252002597 G1 box; other site 754252002598 GTP/Mg2+ binding site [chemical binding]; other site 754252002599 Switch I region; other site 754252002600 G2 box; other site 754252002601 G3 box; other site 754252002602 Switch II region; other site 754252002603 G4 box; other site 754252002604 G5 box; other site 754252002605 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 754252002606 gamma-glutamyl kinase; Provisional; Region: PRK05429 754252002607 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 754252002608 nucleotide binding site [chemical binding]; other site 754252002609 homotetrameric interface [polypeptide binding]; other site 754252002610 putative phosphate binding site [ion binding]; other site 754252002611 putative allosteric binding site; other site 754252002612 PUA domain; Region: PUA; pfam01472 754252002613 Uncharacterized conserved protein [Function unknown]; Region: COG4095 754252002614 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 754252002615 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 754252002616 putative catalytic cysteine [active] 754252002617 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 754252002618 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 754252002619 active site 754252002620 (T/H)XGH motif; other site 754252002621 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 754252002622 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 754252002623 catalytic core [active] 754252002624 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 754252002625 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 754252002626 NAD(P) binding site [chemical binding]; other site 754252002627 active site 754252002628 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 754252002629 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 754252002630 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 754252002631 HIGH motif; other site 754252002632 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 754252002633 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 754252002634 active site 754252002635 KMSKS motif; other site 754252002636 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 754252002637 tRNA binding surface [nucleotide binding]; other site 754252002638 dihydroorotase; Validated; Region: pyrC; PRK09357 754252002639 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 754252002640 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 754252002641 active site 754252002642 malate dehydrogenase; Provisional; Region: PRK13529 754252002643 Malic enzyme, N-terminal domain; Region: malic; pfam00390 754252002644 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 754252002645 NAD(P) binding site [chemical binding]; other site 754252002646 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 754252002647 Helix-hairpin-helix motif; Region: HHH; pfam00633 754252002648 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 754252002649 Competence protein; Region: Competence; pfam03772 754252002650 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 754252002651 DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466 754252002652 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 754252002653 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 754252002654 GTP-binding protein LepA; Provisional; Region: PRK05433 754252002655 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 754252002656 G1 box; other site 754252002657 putative GEF interaction site [polypeptide binding]; other site 754252002658 GTP/Mg2+ binding site [chemical binding]; other site 754252002659 Switch I region; other site 754252002660 G2 box; other site 754252002661 G3 box; other site 754252002662 Switch II region; other site 754252002663 G4 box; other site 754252002664 G5 box; other site 754252002665 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 754252002666 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 754252002667 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 754252002668 coproporphyrinogen III oxidase; Validated; Region: PRK05628 754252002669 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 754252002670 FeS/SAM binding site; other site 754252002671 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 754252002672 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 754252002673 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 754252002674 active site 754252002675 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 754252002676 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 754252002677 chaperone protein DnaJ; Provisional; Region: PRK14278 754252002678 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 754252002679 HSP70 interaction site [polypeptide binding]; other site 754252002680 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 754252002681 Zn binding sites [ion binding]; other site 754252002682 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 754252002683 dimer interface [polypeptide binding]; other site 754252002684 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 754252002685 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 754252002686 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 754252002687 active site 754252002688 metal binding site [ion binding]; metal-binding site 754252002689 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 754252002690 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 754252002691 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 754252002692 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 754252002693 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754252002694 metabolite-proton symporter; Region: 2A0106; TIGR00883 754252002695 putative substrate translocation pore; other site 754252002696 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 754252002697 PhoH-like protein; Region: PhoH; pfam02562 754252002698 metal-binding heat shock protein; Provisional; Region: PRK00016 754252002699 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 754252002700 Domain of unknown function DUF21; Region: DUF21; pfam01595 754252002701 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 754252002702 Transporter associated domain; Region: CorC_HlyC; smart01091 754252002703 GTPase Era; Reviewed; Region: era; PRK00089 754252002704 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 754252002705 G1 box; other site 754252002706 GTP/Mg2+ binding site [chemical binding]; other site 754252002707 Switch I region; other site 754252002708 G2 box; other site 754252002709 Switch II region; other site 754252002710 G3 box; other site 754252002711 G4 box; other site 754252002712 G5 box; other site 754252002713 KH domain; Region: KH_2; pfam07650 754252002714 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 754252002715 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 754252002716 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 754252002717 active site 754252002718 2-isopropylmalate synthase; Validated; Region: PRK03739 754252002719 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 754252002720 active site 754252002721 catalytic residues [active] 754252002722 metal binding site [ion binding]; metal-binding site 754252002723 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 754252002724 Uncharacterized conserved protein [Function unknown]; Region: COG3189 754252002725 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 754252002726 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 754252002727 catalytic residue [active] 754252002728 putative FPP diphosphate binding site; other site 754252002729 putative FPP binding hydrophobic cleft; other site 754252002730 dimer interface [polypeptide binding]; other site 754252002731 putative IPP diphosphate binding site; other site 754252002732 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 754252002733 Recombination protein O N terminal; Region: RecO_N; pfam11967 754252002734 Recombination protein O C terminal; Region: RecO_C; pfam02565 754252002735 Sensory domain found in PocR; Region: PocR; pfam10114 754252002736 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 754252002737 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 754252002738 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 754252002739 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 754252002740 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 754252002741 putative active site [active] 754252002742 metal binding site [ion binding]; metal-binding site 754252002743 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 754252002744 G1 box; other site 754252002745 GTP/Mg2+ binding site [chemical binding]; other site 754252002746 G3 box; other site 754252002747 Switch II region; other site 754252002748 G4 box; other site 754252002749 G5 box; other site 754252002750 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 754252002751 putative hexamer interface [polypeptide binding]; other site 754252002752 putative hexagonal pore; other site 754252002753 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 754252002754 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 754252002755 Hexamer interface [polypeptide binding]; other site 754252002756 Hexagonal pore residue; other site 754252002757 propanediol utilization protein PduB; Provisional; Region: PRK15415 754252002758 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047 754252002759 putative hexamer interface [polypeptide binding]; other site 754252002760 putative hexagonal pore; other site 754252002761 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048 754252002762 putative hexamer interface [polypeptide binding]; other site 754252002763 putative hexagonal pore; other site 754252002764 Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909 754252002765 Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cd03687 754252002766 alpha-alpha subunit/dimer interface [polypeptide binding]; other site 754252002767 alpha-beta subunit interface [polypeptide binding]; other site 754252002768 alpha-gamma subunit interface [polypeptide binding]; other site 754252002769 active site 754252002770 substrate and K+ binding site; other site 754252002771 K+ binding site [ion binding]; other site 754252002772 cobalamin binding site [chemical binding]; other site 754252002773 propanediol dehydratase medium subunit; Provisional; Region: pduD; PRK15042 754252002774 propanediol dehydratase small subunit; Provisional; Region: pduE; PRK15443 754252002775 Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841 754252002776 Dehydratase medium subunit; Region: Dehydratase_MU; cl17703 754252002777 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 754252002778 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 754252002779 Hexamer interface [polypeptide binding]; other site 754252002780 Hexagonal pore residue; other site 754252002781 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 754252002782 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 754252002783 Hexamer interface [polypeptide binding]; other site 754252002784 Hexagonal pore residue; other site 754252002785 ethanolamine utilization protein EutJ; Provisional; Region: PRK15080 754252002786 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 754252002787 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 754252002788 Flavoprotein; Region: Flavoprotein; cl08021 754252002789 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 754252002790 Hexamer/Pentamer interface [polypeptide binding]; other site 754252002791 central pore; other site 754252002792 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 754252002793 Domain of unknown function (DUF336); Region: DUF336; pfam03928 754252002794 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 754252002795 putative catalytic cysteine [active] 754252002796 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 754252002797 active site 754252002798 catalytic residues [active] 754252002799 Int/Topo IB signature motif; other site 754252002800 DNA binding site [nucleotide binding] 754252002801 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 754252002802 metal binding site 2 [ion binding]; metal-binding site 754252002803 putative DNA binding helix; other site 754252002804 metal binding site 1 [ion binding]; metal-binding site 754252002805 dimer interface [polypeptide binding]; other site 754252002806 structural Zn2+ binding site [ion binding]; other site 754252002807 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 754252002808 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 754252002809 ABC-ATPase subunit interface; other site 754252002810 dimer interface [polypeptide binding]; other site 754252002811 putative PBP binding regions; other site 754252002812 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 754252002813 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 754252002814 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 754252002815 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 754252002816 intersubunit interface [polypeptide binding]; other site 754252002817 glycyl-tRNA synthetase; Provisional; Region: PRK04173 754252002818 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 754252002819 motif 1; other site 754252002820 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 754252002821 active site 754252002822 motif 2; other site 754252002823 motif 3; other site 754252002824 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 754252002825 anticodon binding site; other site 754252002826 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 754252002827 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 754252002828 dimerization interface [polypeptide binding]; other site 754252002829 active site 754252002830 L-aspartate oxidase; Provisional; Region: PRK06175 754252002831 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 754252002832 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 754252002833 quinolinate synthetase; Provisional; Region: PRK09375 754252002834 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 754252002835 nudix motif; other site 754252002836 nudix motif; other site 754252002837 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 754252002838 putative Iron-sulfur protein interface [polypeptide binding]; other site 754252002839 proximal heme binding site [chemical binding]; other site 754252002840 distal heme binding site [chemical binding]; other site 754252002841 putative dimer interface [polypeptide binding]; other site 754252002842 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 754252002843 L-aspartate oxidase; Provisional; Region: PRK06175 754252002844 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 754252002845 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 754252002846 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 754252002847 4Fe-4S binding domain; Region: Fer4; pfam00037 754252002848 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 754252002849 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 754252002850 FMN binding site [chemical binding]; other site 754252002851 active site 754252002852 catalytic residues [active] 754252002853 substrate binding site [chemical binding]; other site 754252002854 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 754252002855 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 754252002856 Zn2+ binding site [ion binding]; other site 754252002857 Mg2+ binding site [ion binding]; other site 754252002858 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 754252002859 Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424 754252002860 Predicted metal-binding protein (DUF2284); Region: DUF2284; cl02248 754252002861 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 754252002862 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 754252002863 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 754252002864 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 754252002865 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 754252002866 MoxR-like ATPases [General function prediction only]; Region: COG0714 754252002867 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 754252002868 Walker A motif; other site 754252002869 ATP binding site [chemical binding]; other site 754252002870 Walker B motif; other site 754252002871 arginine finger; other site 754252002872 Protein of unknown function DUF58; Region: DUF58; pfam01882 754252002873 hypothetical protein; Provisional; Region: PRK13685 754252002874 Aerotolerance regulator N-terminal; Region: BatA; cl06567 754252002875 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 754252002876 metal ion-dependent adhesion site (MIDAS); other site 754252002877 von Willebrand factor type A domain; Region: VWA_2; pfam13519 754252002878 metal ion-dependent adhesion site (MIDAS); other site 754252002879 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 754252002880 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 754252002881 catalytic residue [active] 754252002882 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 754252002883 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 754252002884 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 754252002885 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 754252002886 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 754252002887 dimer interface [polypeptide binding]; other site 754252002888 active site 754252002889 acyl carrier protein; Provisional; Region: acpP; PRK00982 754252002890 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 754252002891 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 754252002892 dimer interface [polypeptide binding]; other site 754252002893 active site 754252002894 CoA binding pocket [chemical binding]; other site 754252002895 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 754252002896 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 754252002897 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 754252002898 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 754252002899 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 754252002900 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754252002901 homodimer interface [polypeptide binding]; other site 754252002902 catalytic residue [active] 754252002903 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 754252002904 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 754252002905 dimer interface [polypeptide binding]; other site 754252002906 TPP-binding site [chemical binding]; other site 754252002907 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 754252002908 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 754252002909 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 754252002910 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754252002911 Walker A/P-loop; other site 754252002912 ATP binding site [chemical binding]; other site 754252002913 Q-loop/lid; other site 754252002914 ABC transporter signature motif; other site 754252002915 Walker B; other site 754252002916 D-loop; other site 754252002917 H-loop/switch region; other site 754252002918 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 754252002919 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 754252002920 putative dimer interface [polypeptide binding]; other site 754252002921 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 754252002922 Predicted amidohydrolase [General function prediction only]; Region: COG0388 754252002923 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 754252002924 active site 754252002925 catalytic triad [active] 754252002926 dimer interface [polypeptide binding]; other site 754252002927 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 754252002928 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 754252002929 inhibitor-cofactor binding pocket; inhibition site 754252002930 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754252002931 catalytic residue [active] 754252002932 Fructosamine kinase; Region: Fructosamin_kin; cl17579 754252002933 Yqey-like protein; Region: YqeY; cl17540 754252002934 peptide chain release factor 2; Validated; Region: prfB; PRK00578 754252002935 This domain is found in peptide chain release factors; Region: PCRF; smart00937 754252002936 RF-1 domain; Region: RF-1; pfam00472 754252002937 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 754252002938 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754252002939 Walker A/P-loop; other site 754252002940 ATP binding site [chemical binding]; other site 754252002941 Q-loop/lid; other site 754252002942 ABC transporter signature motif; other site 754252002943 Walker B; other site 754252002944 D-loop; other site 754252002945 H-loop/switch region; other site 754252002946 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 754252002947 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 754252002948 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 754252002949 Peptidase family M23; Region: Peptidase_M23; pfam01551 754252002950 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 754252002951 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 754252002952 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 754252002953 SmpB-tmRNA interface; other site 754252002954 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 754252002955 Tic20-like protein; Region: Tic20; pfam09685 754252002956 hypothetical protein; Validated; Region: PRK00228 754252002957 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 754252002958 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754252002959 active site 754252002960 phosphorylation site [posttranslational modification] 754252002961 intermolecular recognition site; other site 754252002962 dimerization interface [polypeptide binding]; other site 754252002963 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 754252002964 DNA binding site [nucleotide binding] 754252002965 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 754252002966 30S subunit binding site; other site 754252002967 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 754252002968 DEAD/DEAH box helicase; Region: DEAD; pfam00270 754252002969 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 754252002970 SEC-C motif; Region: SEC-C; pfam02810 754252002971 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 754252002972 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 754252002973 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 754252002974 active site 754252002975 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 754252002976 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 754252002977 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 754252002978 active site 754252002979 HIGH motif; other site 754252002980 dimer interface [polypeptide binding]; other site 754252002981 KMSKS motif; other site 754252002982 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 754252002983 DEAD-like helicases superfamily; Region: DEXDc; smart00487 754252002984 ATP binding site [chemical binding]; other site 754252002985 Mg++ binding site [ion binding]; other site 754252002986 motif III; other site 754252002987 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 754252002988 nucleotide binding region [chemical binding]; other site 754252002989 ATP-binding site [chemical binding]; other site 754252002990 tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like; Region: MiaE_2; pfam13794 754252002991 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 754252002992 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 754252002993 active site 754252002994 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 754252002995 DNA-binding site [nucleotide binding]; DNA binding site 754252002996 RNA-binding motif; other site 754252002997 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 754252002998 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 754252002999 Family description; Region: UvrD_C_2; pfam13538 754252003000 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 754252003001 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 754252003002 Part of AAA domain; Region: AAA_19; pfam13245 754252003003 Family description; Region: UvrD_C_2; pfam13538 754252003004 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 754252003005 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 754252003006 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 754252003007 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 754252003008 putative NADH binding site [chemical binding]; other site 754252003009 putative active site [active] 754252003010 nudix motif; other site 754252003011 putative metal binding site [ion binding]; other site 754252003012 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 754252003013 AAA domain; Region: AAA_30; pfam13604 754252003014 Family description; Region: UvrD_C_2; pfam13538 754252003015 Part of AAA domain; Region: AAA_19; pfam13245 754252003016 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 754252003017 Family description; Region: UvrD_C_2; pfam13538 754252003018 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 754252003019 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 754252003020 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 754252003021 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 754252003022 Part of AAA domain; Region: AAA_19; pfam13245 754252003023 Family description; Region: UvrD_C_2; pfam13538 754252003024 HRDC domain; Region: HRDC; pfam00570 754252003025 Protein of unknown function DUF45; Region: DUF45; cl00636 754252003026 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 754252003027 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 754252003028 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 754252003029 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 754252003030 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 754252003031 Uncharacterized conserved protein [Function unknown]; Region: COG1615 754252003032 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 754252003033 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 754252003034 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 754252003035 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 754252003036 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 754252003037 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 754252003038 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 754252003039 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 754252003040 Predicted acetyltransferase [General function prediction only]; Region: COG2388 754252003041 biotin synthase; Validated; Region: PRK06256 754252003042 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 754252003043 FeS/SAM binding site; other site 754252003044 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 754252003045 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 754252003046 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 754252003047 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 754252003048 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754252003049 dimer interface [polypeptide binding]; other site 754252003050 conserved gate region; other site 754252003051 putative PBP binding loops; other site 754252003052 ABC-ATPase subunit interface; other site 754252003053 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 754252003054 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754252003055 dimer interface [polypeptide binding]; other site 754252003056 conserved gate region; other site 754252003057 putative PBP binding loops; other site 754252003058 ABC-ATPase subunit interface; other site 754252003059 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 754252003060 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 754252003061 Walker A/P-loop; other site 754252003062 ATP binding site [chemical binding]; other site 754252003063 Q-loop/lid; other site 754252003064 ABC transporter signature motif; other site 754252003065 Walker B; other site 754252003066 D-loop; other site 754252003067 H-loop/switch region; other site 754252003068 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 754252003069 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 754252003070 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 754252003071 Walker A/P-loop; other site 754252003072 ATP binding site [chemical binding]; other site 754252003073 Q-loop/lid; other site 754252003074 ABC transporter signature motif; other site 754252003075 Walker B; other site 754252003076 D-loop; other site 754252003077 H-loop/switch region; other site 754252003078 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 754252003079 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 754252003080 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 754252003081 ligand binding site [chemical binding]; other site 754252003082 NAD binding site [chemical binding]; other site 754252003083 tetramer interface [polypeptide binding]; other site 754252003084 catalytic site [active] 754252003085 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 754252003086 L-serine binding site [chemical binding]; other site 754252003087 ACT domain interface; other site 754252003090 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 754252003091 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 754252003092 putative metal binding residues [ion binding]; other site 754252003093 signature motif; other site 754252003094 dimer interface [polypeptide binding]; other site 754252003095 active site 754252003096 polyP binding site; other site 754252003097 substrate binding site [chemical binding]; other site 754252003098 acceptor-phosphate pocket; other site 754252003099 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 754252003100 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 754252003101 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 754252003102 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 754252003103 active site 754252003104 Predicted GTPases [General function prediction only]; Region: COG1162 754252003105 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 754252003106 GTPase/Zn-binding domain interface [polypeptide binding]; other site 754252003107 GTP/Mg2+ binding site [chemical binding]; other site 754252003108 G4 box; other site 754252003109 G5 box; other site 754252003110 G1 box; other site 754252003111 Switch I region; other site 754252003112 G2 box; other site 754252003113 G3 box; other site 754252003114 Switch II region; other site 754252003115 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 754252003116 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 754252003117 hinge; other site 754252003118 active site 754252003119 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 754252003120 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 754252003121 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 754252003122 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 754252003123 DNA binding residues [nucleotide binding] 754252003124 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 754252003125 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 754252003126 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 754252003127 Histidine kinase; Region: HisKA_2; pfam07568 754252003128 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 754252003129 ATP binding site [chemical binding]; other site 754252003130 Mg2+ binding site [ion binding]; other site 754252003131 G-X-G motif; other site 754252003132 Transcription factor WhiB; Region: Whib; pfam02467 754252003133 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 754252003134 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 754252003135 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 754252003136 TPP-binding site [chemical binding]; other site 754252003137 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 754252003138 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 754252003139 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 754252003140 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 754252003141 diaminopimelate decarboxylase; Region: lysA; TIGR01048 754252003142 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 754252003143 active site 754252003144 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 754252003145 substrate binding site [chemical binding]; other site 754252003146 catalytic residues [active] 754252003147 dimer interface [polypeptide binding]; other site 754252003148 homoserine dehydrogenase; Provisional; Region: PRK06349 754252003149 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 754252003150 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 754252003151 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 754252003152 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 754252003153 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 754252003154 motif II; other site 754252003155 transcription termination factor Rho; Provisional; Region: PRK12678 754252003156 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 754252003157 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 754252003158 RNA binding site [nucleotide binding]; other site 754252003159 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 754252003160 Walker A motif; other site 754252003161 ATP binding site [chemical binding]; other site 754252003162 Walker B motif; other site 754252003163 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 754252003164 peptide chain release factor 1; Validated; Region: prfA; PRK00591 754252003165 PCRF domain; Region: PCRF; pfam03462 754252003166 RF-1 domain; Region: RF-1; pfam00472 754252003167 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 754252003168 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754252003169 S-adenosylmethionine binding site [chemical binding]; other site 754252003170 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 754252003171 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 754252003172 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 754252003173 Mg++ binding site [ion binding]; other site 754252003174 putative catalytic motif [active] 754252003175 substrate binding site [chemical binding]; other site 754252003176 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754 754252003177 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 754252003178 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 754252003179 ATP synthase subunit C; Region: ATP-synt_C; cl00466 754252003180 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 754252003181 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 754252003182 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210 754252003183 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 754252003184 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 754252003185 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 754252003186 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 754252003187 beta subunit interaction interface [polypeptide binding]; other site 754252003188 Walker A motif; other site 754252003189 ATP binding site [chemical binding]; other site 754252003190 Walker B motif; other site 754252003191 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 754252003192 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 754252003193 core domain interface [polypeptide binding]; other site 754252003194 delta subunit interface [polypeptide binding]; other site 754252003195 epsilon subunit interface [polypeptide binding]; other site 754252003196 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 754252003197 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 754252003198 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 754252003199 alpha subunit interaction interface [polypeptide binding]; other site 754252003200 Walker A motif; other site 754252003201 ATP binding site [chemical binding]; other site 754252003202 Walker B motif; other site 754252003203 inhibitor binding site; inhibition site 754252003204 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 754252003205 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 754252003206 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 754252003207 gamma subunit interface [polypeptide binding]; other site 754252003208 epsilon subunit interface [polypeptide binding]; other site 754252003209 LBP interface [polypeptide binding]; other site 754252003210 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 754252003211 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 754252003212 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 754252003213 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 754252003214 PGAP1-like protein; Region: PGAP1; pfam07819 754252003215 hypothetical protein; Provisional; Region: PRK03298 754252003216 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 754252003217 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988 754252003218 putative acyl-acceptor binding pocket; other site 754252003219 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 754252003220 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 754252003221 dimer interface [polypeptide binding]; other site 754252003222 substrate binding site [chemical binding]; other site 754252003223 metal binding site [ion binding]; metal-binding site 754252003224 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 754252003225 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 754252003226 phosphoglucomutase; Validated; Region: PRK07564 754252003227 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 754252003228 active site 754252003229 substrate binding site [chemical binding]; other site 754252003230 metal binding site [ion binding]; metal-binding site 754252003231 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 754252003232 nudix motif; other site 754252003233 glycogen branching enzyme; Provisional; Region: PRK12313 754252003234 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 754252003235 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 754252003236 active site 754252003237 catalytic site [active] 754252003238 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 754252003239 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 754252003240 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 754252003241 trehalose synthase; Region: treS_nterm; TIGR02456 754252003242 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 754252003243 active site 754252003244 catalytic site [active] 754252003245 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 754252003246 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 754252003247 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 754252003248 active site 754252003249 homodimer interface [polypeptide binding]; other site 754252003250 catalytic site [active] 754252003251 acceptor binding site [chemical binding]; other site 754252003252 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 754252003253 putative homodimer interface [polypeptide binding]; other site 754252003254 putative active site pocket [active] 754252003255 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 754252003256 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 754252003257 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 754252003258 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 754252003259 active site 754252003260 catalytic site [active] 754252003261 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 754252003262 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 754252003263 Ligand Binding Site [chemical binding]; other site 754252003264 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 754252003265 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 754252003266 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 754252003267 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 754252003268 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 754252003269 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 754252003270 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 754252003271 GatB domain; Region: GatB_Yqey; smart00845 754252003272 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 754252003275 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 754252003276 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 754252003277 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 754252003278 active site 754252003279 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 754252003280 active pocket/dimerization site; other site 754252003281 active site 754252003282 phosphorylation site [posttranslational modification] 754252003283 FOG: CBS domain [General function prediction only]; Region: COG0517 754252003284 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc2; cd04585 754252003285 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 754252003286 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 754252003287 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 754252003288 Walker A/P-loop; other site 754252003289 ATP binding site [chemical binding]; other site 754252003290 Q-loop/lid; other site 754252003291 ABC transporter signature motif; other site 754252003292 Walker B; other site 754252003293 D-loop; other site 754252003294 H-loop/switch region; other site 754252003295 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 754252003296 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 754252003297 Walker A/P-loop; other site 754252003298 ATP binding site [chemical binding]; other site 754252003299 Q-loop/lid; other site 754252003300 ABC transporter signature motif; other site 754252003301 Walker B; other site 754252003302 D-loop; other site 754252003303 H-loop/switch region; other site 754252003304 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 754252003305 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 754252003306 TM-ABC transporter signature motif; other site 754252003307 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 754252003308 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 754252003309 TM-ABC transporter signature motif; other site 754252003310 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 754252003311 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 754252003312 putative ligand binding site [chemical binding]; other site 754252003313 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 754252003314 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 754252003315 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 754252003316 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 754252003317 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 754252003318 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 754252003319 non-specific DNA binding site [nucleotide binding]; other site 754252003320 salt bridge; other site 754252003321 sequence-specific DNA binding site [nucleotide binding]; other site 754252003322 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 754252003323 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 754252003324 putative active site [active] 754252003325 pyridoxamine kinase; Validated; Region: PRK05756 754252003326 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 754252003327 dimer interface [polypeptide binding]; other site 754252003328 pyridoxal binding site [chemical binding]; other site 754252003329 ATP binding site [chemical binding]; other site 754252003330 Putative transmembrane protein (PGPGW); Region: PGPGW; cl09870 754252003331 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 754252003332 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 754252003333 active site 754252003334 catalytic site [active] 754252003335 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 754252003336 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 754252003337 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 754252003338 Ligand binding site; other site 754252003339 Putative Catalytic site; other site 754252003340 DXD motif; other site 754252003341 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 754252003342 putative active site [active] 754252003343 catalytic triad [active] 754252003344 putative dimer interface [polypeptide binding]; other site 754252003345 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 754252003346 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 754252003347 putative DNA binding site [nucleotide binding]; other site 754252003348 putative Zn2+ binding site [ion binding]; other site 754252003349 AsnC family; Region: AsnC_trans_reg; pfam01037 754252003350 Methyltransferase domain; Region: Methyltransf_31; pfam13847 754252003351 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754252003352 S-adenosylmethionine binding site [chemical binding]; other site 754252003353 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 754252003354 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 754252003355 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 754252003356 substrate binding pocket [chemical binding]; other site 754252003357 NMT1/THI5 like; Region: NMT1; pfam09084 754252003358 membrane-bound complex binding site; other site 754252003359 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 754252003360 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754252003361 dimer interface [polypeptide binding]; other site 754252003362 conserved gate region; other site 754252003363 putative PBP binding loops; other site 754252003364 ABC-ATPase subunit interface; other site 754252003365 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754252003366 Major Facilitator Superfamily; Region: MFS_1; pfam07690 754252003367 putative substrate translocation pore; other site 754252003368 S-ribosylhomocysteinase; Provisional; Region: PRK02260 754252003369 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 754252003370 active site 754252003371 catalytic residues [active] 754252003372 DNA binding site [nucleotide binding] 754252003373 Int/Topo IB signature motif; other site 754252003374 Helix-turn-helix domain; Region: HTH_17; pfam12728 754252003375 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 754252003376 generic binding surface I; other site 754252003377 generic binding surface II; other site 754252003380 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 754252003381 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 754252003382 Walker A motif; other site 754252003383 ATP binding site [chemical binding]; other site 754252003384 Walker B motif; other site 754252003385 arginine finger; other site 754252003386 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847 754252003387 active site 754252003388 catalytic triad [active] 754252003389 Divergent AAA domain; Region: AAA_4; pfam04326 754252003390 Transcriptional regulators [Transcription]; Region: MarR; COG1846 754252003391 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 754252003392 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 754252003393 EamA-like transporter family; Region: EamA; pfam00892 754252003394 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 754252003395 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 754252003396 NAD(P) binding site [chemical binding]; other site 754252003399 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 754252003400 GTP-binding protein Der; Reviewed; Region: PRK03003 754252003401 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 754252003402 G1 box; other site 754252003403 GTP/Mg2+ binding site [chemical binding]; other site 754252003404 Switch I region; other site 754252003405 G2 box; other site 754252003406 Switch II region; other site 754252003407 G3 box; other site 754252003408 G4 box; other site 754252003409 G5 box; other site 754252003410 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 754252003411 G1 box; other site 754252003412 GTP/Mg2+ binding site [chemical binding]; other site 754252003413 Switch I region; other site 754252003414 G2 box; other site 754252003415 G3 box; other site 754252003416 Switch II region; other site 754252003417 G4 box; other site 754252003418 G5 box; other site 754252003419 cytidylate kinase; Provisional; Region: cmk; PRK00023 754252003420 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 754252003421 CMP-binding site; other site 754252003422 The sites determining sugar specificity; other site 754252003423 prephenate dehydrogenase; Validated; Region: PRK06545 754252003424 prephenate dehydrogenase; Validated; Region: PRK08507 754252003425 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cd02116 754252003426 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 754252003427 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 754252003428 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 754252003429 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 754252003430 active site 754252003431 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 754252003432 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 754252003433 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 754252003434 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 754252003435 motif II; other site 754252003436 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 754252003437 tandem repeat interface [polypeptide binding]; other site 754252003438 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 754252003439 oligomer interface [polypeptide binding]; other site 754252003440 active site residues [active] 754252003441 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 754252003442 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 754252003443 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 754252003444 substrate binding pocket [chemical binding]; other site 754252003445 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 754252003446 B12 binding site [chemical binding]; other site 754252003447 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 754252003448 PAC2 family; Region: PAC2; pfam09754 754252003449 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 754252003450 trimer interface [polypeptide binding]; other site 754252003451 active site 754252003452 G bulge; other site 754252003453 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 754252003454 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 754252003455 substrate binding site [chemical binding]; other site 754252003456 hexamer interface [polypeptide binding]; other site 754252003457 metal binding site [ion binding]; metal-binding site 754252003458 16S rRNA methyltransferase B; Provisional; Region: PRK14902 754252003459 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 754252003460 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 754252003461 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 754252003462 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 754252003463 putative active site [active] 754252003464 substrate binding site [chemical binding]; other site 754252003465 putative cosubstrate binding site; other site 754252003466 catalytic site [active] 754252003467 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 754252003468 substrate binding site [chemical binding]; other site 754252003469 primosome assembly protein PriA; Provisional; Region: PRK14873 754252003470 S-adenosylmethionine synthetase; Validated; Region: PRK05250 754252003471 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 754252003472 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 754252003473 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 754252003474 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 754252003475 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 754252003476 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 754252003477 catalytic site [active] 754252003478 G-X2-G-X-G-K; other site 754252003479 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 754252003480 active site 754252003481 dimer interface [polypeptide binding]; other site 754252003482 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 754252003483 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 754252003484 quinone interaction residues [chemical binding]; other site 754252003485 active site 754252003486 catalytic residues [active] 754252003487 FMN binding site [chemical binding]; other site 754252003488 substrate binding site [chemical binding]; other site 754252003489 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 754252003490 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 754252003491 ATP-grasp domain; Region: ATP-grasp_4; cl17255 754252003492 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 754252003493 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 754252003494 ATP-grasp domain; Region: ATP-grasp_4; cl17255 754252003495 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 754252003496 IMP binding site; other site 754252003497 dimer interface [polypeptide binding]; other site 754252003498 interdomain contacts; other site 754252003499 partial ornithine binding site; other site 754252003500 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 754252003501 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 754252003502 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 754252003503 catalytic site [active] 754252003504 subunit interface [polypeptide binding]; other site 754252003505 transcription antitermination factor NusB; Region: nusB; TIGR01951 754252003506 putative RNA binding site [nucleotide binding]; other site 754252003507 elongation factor P; Validated; Region: PRK00529 754252003508 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 754252003509 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 754252003510 RNA binding site [nucleotide binding]; other site 754252003511 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 754252003512 RNA binding site [nucleotide binding]; other site 754252003513 bifunctional shikimate kinase/3-dehydroquinate synthase; Provisional; Region: PRK14021 754252003514 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 754252003515 ADP binding site [chemical binding]; other site 754252003516 magnesium binding site [ion binding]; other site 754252003517 putative shikimate binding site; other site 754252003518 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 754252003519 active site 754252003520 dimer interface [polypeptide binding]; other site 754252003521 metal binding site [ion binding]; metal-binding site 754252003522 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 754252003523 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 754252003524 Tetramer interface [polypeptide binding]; other site 754252003525 active site 754252003526 FMN-binding site [chemical binding]; other site 754252003527 YceG-like family; Region: YceG; pfam02618 754252003528 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 754252003529 dimerization interface [polypeptide binding]; other site 754252003530 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 754252003531 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 754252003532 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 754252003533 motif 1; other site 754252003534 active site 754252003535 motif 2; other site 754252003536 motif 3; other site 754252003537 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 754252003538 DHHA1 domain; Region: DHHA1; pfam02272 754252003539 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 754252003540 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 754252003541 NAD(P) binding site [chemical binding]; other site 754252003542 LDH/MDH dimer interface [polypeptide binding]; other site 754252003543 substrate binding site [chemical binding]; other site 754252003544 recombination factor protein RarA; Reviewed; Region: PRK13342 754252003545 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 754252003546 Walker A motif; other site 754252003547 ATP binding site [chemical binding]; other site 754252003548 Walker B motif; other site 754252003549 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 754252003550 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 754252003551 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 754252003552 dimer interface [polypeptide binding]; other site 754252003553 anticodon binding site; other site 754252003554 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 754252003555 homodimer interface [polypeptide binding]; other site 754252003556 motif 1; other site 754252003557 active site 754252003558 motif 2; other site 754252003559 GAD domain; Region: GAD; pfam02938 754252003560 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 754252003561 active site 754252003562 motif 3; other site 754252003563 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 754252003564 histidyl-tRNA synthetase; Region: hisS; TIGR00442 754252003565 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 754252003566 dimer interface [polypeptide binding]; other site 754252003567 motif 1; other site 754252003568 active site 754252003569 motif 2; other site 754252003570 motif 3; other site 754252003571 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 754252003572 anticodon binding site; other site 754252003573 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 754252003574 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 754252003575 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 754252003576 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 754252003577 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 754252003578 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 754252003579 Zn2+ binding site [ion binding]; other site 754252003580 Mg2+ binding site [ion binding]; other site 754252003581 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 754252003582 synthetase active site [active] 754252003583 NTP binding site [chemical binding]; other site 754252003584 metal binding site [ion binding]; metal-binding site 754252003585 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 754252003586 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 754252003587 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 754252003588 active site 754252003589 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 754252003590 Protein export membrane protein; Region: SecD_SecF; pfam02355 754252003591 Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342 754252003592 Protein export membrane protein; Region: SecD_SecF; cl14618 754252003593 Preprotein translocase subunit; Region: YajC; pfam02699 754252003594 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 754252003595 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 754252003596 Walker A motif; other site 754252003597 ATP binding site [chemical binding]; other site 754252003598 Walker B motif; other site 754252003599 arginine finger; other site 754252003600 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 754252003601 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 754252003602 RuvA N terminal domain; Region: RuvA_N; pfam01330 754252003603 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 754252003604 active site 754252003605 putative DNA-binding cleft [nucleotide binding]; other site 754252003606 dimer interface [polypeptide binding]; other site 754252003607 hypothetical protein; Validated; Region: PRK00110 754252003608 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 754252003609 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 754252003610 Coenzyme A binding pocket [chemical binding]; other site 754252003611 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 754252003612 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 754252003613 catalytic residues [active] 754252003614 Glutamine amidotransferase [Amino acid transport and metabolism]; Region: HisH; COG0118 754252003615 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 754252003616 putative active site [active] 754252003617 oxyanion strand; other site 754252003618 catalytic triad [active] 754252003619 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 754252003620 putative active site pocket [active] 754252003621 4-fold oligomerization interface [polypeptide binding]; other site 754252003622 metal binding residues [ion binding]; metal-binding site 754252003623 3-fold/trimer interface [polypeptide binding]; other site 754252003624 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 754252003625 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 754252003626 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754252003627 homodimer interface [polypeptide binding]; other site 754252003628 catalytic residue [active] 754252003629 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 754252003630 histidinol dehydrogenase; Region: hisD; TIGR00069 754252003631 NAD binding site [chemical binding]; other site 754252003632 dimerization interface [polypeptide binding]; other site 754252003633 product binding site; other site 754252003634 substrate binding site [chemical binding]; other site 754252003635 zinc binding site [ion binding]; other site 754252003636 catalytic residues [active] 754252003637 Protein of unknown function (DUF554); Region: DUF554; pfam04474 754252003638 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 754252003639 putative deacylase active site [active] 754252003640 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 754252003641 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 754252003642 active site 754252003643 PHP Thumb interface [polypeptide binding]; other site 754252003644 metal binding site [ion binding]; metal-binding site 754252003645 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 754252003646 generic binding surface II; other site 754252003647 generic binding surface I; other site 754252003648 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 754252003649 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 754252003650 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 754252003651 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 754252003652 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 754252003653 active site 754252003654 dimer interface [polypeptide binding]; other site 754252003655 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 754252003656 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 754252003657 active site 754252003658 FMN binding site [chemical binding]; other site 754252003659 substrate binding site [chemical binding]; other site 754252003660 3Fe-4S cluster binding site [ion binding]; other site 754252003661 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 754252003662 domain interface; other site 754252003663 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 754252003664 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 754252003665 substrate binding site [chemical binding]; other site 754252003666 active site 754252003667 catalytic residues [active] 754252003668 heterodimer interface [polypeptide binding]; other site 754252003669 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 754252003670 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 754252003671 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754252003672 catalytic residue [active] 754252003673 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 754252003674 active site 754252003675 ribulose/triose binding site [chemical binding]; other site 754252003676 phosphate binding site [ion binding]; other site 754252003677 substrate (anthranilate) binding pocket [chemical binding]; other site 754252003678 product (indole) binding pocket [chemical binding]; other site 754252003679 anthranilate synthase component I; Provisional; Region: PRK13571 754252003680 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 754252003681 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 754252003682 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 754252003683 TIGR03085 family protein; Region: TIGR03085 754252003684 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 754252003685 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 754252003686 active site 754252003687 HIGH motif; other site 754252003688 nucleotide binding site [chemical binding]; other site 754252003689 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 754252003690 active site 754252003691 KMSKS motif; other site 754252003692 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 754252003693 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 754252003694 catalytic core [active] 754252003695 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 754252003696 zinc binding site [ion binding]; other site 754252003697 putative ligand binding site [chemical binding]; other site 754252003698 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 754252003699 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 754252003700 TM-ABC transporter signature motif; other site 754252003701 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 754252003702 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754252003703 Walker A/P-loop; other site 754252003704 ATP binding site [chemical binding]; other site 754252003705 Q-loop/lid; other site 754252003706 ABC transporter signature motif; other site 754252003707 Walker B; other site 754252003708 D-loop; other site 754252003709 H-loop/switch region; other site 754252003710 PAC2 family; Region: PAC2; pfam09754 754252003711 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 754252003712 Rhomboid family; Region: Rhomboid; cl11446 754252003713 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 754252003714 pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated; Region: PRK06555 754252003715 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 754252003716 active site 754252003717 ADP/pyrophosphate binding site [chemical binding]; other site 754252003718 allosteric effector site; other site 754252003719 fructose-1,6-bisphosphate binding site; other site 754252003720 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 754252003721 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 754252003722 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 754252003723 DNA binding residues [nucleotide binding] 754252003724 DNA primase; Validated; Region: dnaG; PRK05667 754252003725 CHC2 zinc finger; Region: zf-CHC2; pfam01807 754252003726 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 754252003727 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 754252003728 active site 754252003729 metal binding site [ion binding]; metal-binding site 754252003730 interdomain interaction site; other site 754252003731 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 754252003732 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 754252003733 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 754252003734 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 754252003735 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 754252003736 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 754252003737 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 754252003738 active site 754252003739 motif I; other site 754252003740 motif II; other site 754252003741 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 754252003742 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 754252003743 active site 754252003744 homotetramer interface [polypeptide binding]; other site 754252003745 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 754252003746 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 754252003747 cobyric acid synthase; Provisional; Region: PRK00784 754252003748 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 754252003749 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 754252003750 catalytic triad [active] 754252003751 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 754252003752 cob(I)alamin adenolsyltransferase/cobinamide ATP-dependent adenolsyltransferase; Validated; Region: PRK05986 754252003753 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 754252003754 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 754252003755 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 754252003756 catalytic triad [active] 754252003757 hypothetical protein; Provisional; Region: PRK07908 754252003758 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 754252003759 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754252003760 homodimer interface [polypeptide binding]; other site 754252003761 catalytic residue [active] 754252003762 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 754252003763 homotrimer interface [polypeptide binding]; other site 754252003764 Walker A motif; other site 754252003765 GTP binding site [chemical binding]; other site 754252003766 Walker B motif; other site 754252003767 cobalamin synthase; Reviewed; Region: cobS; PRK00235 754252003768 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 754252003769 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 754252003770 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754252003771 Walker A/P-loop; other site 754252003772 ATP binding site [chemical binding]; other site 754252003773 Q-loop/lid; other site 754252003774 ABC transporter signature motif; other site 754252003775 Walker B; other site 754252003776 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 754252003777 Predicted membrane protein [Function unknown]; Region: COG1511 754252003778 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 754252003779 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 754252003780 glycine dehydrogenase; Provisional; Region: PRK05367 754252003781 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 754252003782 tetramer interface [polypeptide binding]; other site 754252003783 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754252003784 catalytic residue [active] 754252003785 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 754252003786 tetramer interface [polypeptide binding]; other site 754252003787 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754252003788 catalytic residue [active] 754252003789 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 754252003790 DNA binding residues [nucleotide binding] 754252003791 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 754252003792 putative dimer interface [polypeptide binding]; other site 754252003793 Bifunctional nuclease; Region: DNase-RNase; cl00553 754252003794 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 754252003795 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 754252003796 DNA binding residues [nucleotide binding] 754252003797 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 754252003798 Double zinc ribbon; Region: DZR; pfam12773 754252003799 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 754252003800 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 754252003801 phosphopeptide binding site; other site 754252003802 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 754252003803 lipoyl attachment site [posttranslational modification]; other site 754252003804 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 754252003805 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 754252003806 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 754252003807 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 754252003808 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 754252003809 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 754252003810 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 754252003811 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 754252003812 putative acyl-acceptor binding pocket; other site 754252003813 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 754252003814 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 754252003815 nucleotide binding site/active site [active] 754252003816 HIT family signature motif; other site 754252003817 catalytic residue [active] 754252003818 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 754252003819 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 754252003820 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 754252003821 active site 754252003822 dimer interface [polypeptide binding]; other site 754252003823 motif 1; other site 754252003824 motif 2; other site 754252003825 motif 3; other site 754252003826 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 754252003827 anticodon binding site; other site 754252003828 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 754252003829 putative active site [active] 754252003830 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 754252003831 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 754252003832 SelR domain; Region: SelR; pfam01641 754252003833 PA2301 is an uncharacterized Pseudomonas aeruginosa protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's...; Region: PA2301; cd04939 754252003834 putative deacylase active site [active] 754252003835 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 754252003836 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 754252003837 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 754252003838 catalytic site [active] 754252003839 putative active site [active] 754252003840 putative substrate binding site [chemical binding]; other site 754252003841 HRDC domain; Region: HRDC; pfam00570 754252003842 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 754252003843 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 754252003844 TPP-binding site; other site 754252003845 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 754252003846 PYR/PP interface [polypeptide binding]; other site 754252003847 dimer interface [polypeptide binding]; other site 754252003848 TPP binding site [chemical binding]; other site 754252003849 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 754252003850 Uncharacterized protein conserved in bacteria (DUF2316); Region: DUF2316; cl01805 754252003851 aconitate hydratase; Validated; Region: PRK09277 754252003852 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 754252003853 substrate binding site [chemical binding]; other site 754252003854 ligand binding site [chemical binding]; other site 754252003855 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 754252003856 substrate binding site [chemical binding]; other site 754252003857 metabolite-proton symporter; Region: 2A0106; TIGR00883 754252003858 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754252003859 putative substrate translocation pore; other site 754252003860 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 754252003861 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 754252003862 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 754252003863 putative dimer interface [polypeptide binding]; other site 754252003864 N-terminal domain interface [polypeptide binding]; other site 754252003865 putative substrate binding pocket (H-site) [chemical binding]; other site 754252003866 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 754252003867 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 754252003868 dimer interface [polypeptide binding]; other site 754252003869 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754252003870 catalytic residue [active] 754252003871 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 754252003872 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 754252003873 Coenzyme A binding pocket [chemical binding]; other site 754252003874 RX + glutathione <=> HX + R-S-glutathione 754252003875 RX + glutathione <=> HX + R-S-glutathione 754252003876 TRAM domain; Region: TRAM; pfam01938 754252003877 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 754252003878 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754252003879 S-adenosylmethionine binding site [chemical binding]; other site 754252003880 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 754252003881 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 754252003882 TrkA-N domain; Region: TrkA_N; pfam02254 754252003883 TrkA-C domain; Region: TrkA_C; pfam02080 754252003884 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 754252003885 TrkA-N domain; Region: TrkA_N; pfam02254 754252003886 TrkA-C domain; Region: TrkA_C; pfam02080 754252003887 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 754252003888 generic binding surface II; other site 754252003889 ssDNA binding site; other site 754252003890 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 754252003891 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 754252003892 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 754252003893 Uncharacterized conserved protein [Function unknown]; Region: COG3379 754252003894 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 754252003895 Uncharacterized conserved protein [Function unknown]; Region: COG4850 754252003896 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 754252003897 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 754252003898 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 754252003899 CAP-like domain; other site 754252003900 active site 754252003901 primary dimer interface [polypeptide binding]; other site 754252003902 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 754252003903 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 754252003904 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 754252003905 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 754252003906 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 754252003907 ATP binding site [chemical binding]; other site 754252003908 Mg2+ binding site [ion binding]; other site 754252003909 G-X-G motif; other site 754252003910 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 754252003911 anchoring element; other site 754252003912 dimer interface [polypeptide binding]; other site 754252003913 ATP binding site [chemical binding]; other site 754252003914 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 754252003915 active site 754252003916 metal binding site [ion binding]; metal-binding site 754252003917 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 754252003918 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 754252003919 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 754252003920 NAD(P) binding site [chemical binding]; other site 754252003921 LDH/MDH dimer interface [polypeptide binding]; other site 754252003922 substrate binding site [chemical binding]; other site 754252003923 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 754252003924 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 754252003925 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 754252003926 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 754252003927 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 754252003928 DNA binding residues [nucleotide binding] 754252003929 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 754252003930 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 754252003931 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 754252003932 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 754252003933 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 754252003934 DNA binding residues [nucleotide binding] 754252003935 Repressor of the lactose operon. Binds lactose as an inducer. 754252003937 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 754252003938 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 754252003939 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 754252003940 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 754252003941 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 754252003942 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 754252003943 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 754252003944 active site 754252003945 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 754252003946 catalytic triad [active] 754252003947 dimer interface [polypeptide binding]; other site 754252003948 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 754252003949 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 754252003950 ATP binding site [chemical binding]; other site 754252003951 putative Mg++ binding site [ion binding]; other site 754252003952 nucleotide binding region [chemical binding]; other site 754252003953 helicase superfamily c-terminal domain; Region: HELICc; smart00490 754252003954 ATP-binding site [chemical binding]; other site 754252003955 Helicase associated domain (HA2); Region: HA2; pfam04408 754252003956 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 754252003957 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 754252003958 putative transposase OrfB; Reviewed; Region: PHA02517 754252003959 HTH-like domain; Region: HTH_21; pfam13276 754252003960 Integrase core domain; Region: rve; pfam00665 754252003961 Integrase core domain; Region: rve_3; cl15866 754252003962 Transposase; Region: HTH_Tnp_1; cl17663 754252003963 putative phosphoketolase; Provisional; Region: PRK05261 754252003964 XFP N-terminal domain; Region: XFP_N; pfam09364 754252003965 XFP C-terminal domain; Region: XFP_C; pfam09363 754252003966 Predicted permeases [General function prediction only]; Region: COG0679 754252003967 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 754252003968 Helix-turn-helix domain; Region: HTH_38; pfam13936 754252003969 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 754252003970 sn-glycerol-3-phosphate dehydrogenase subunit C; Provisional; Region: glpC; PRK11168 754252003971 Cysteine-rich domain; Region: CCG; pfam02754 754252003972 Cysteine-rich domain; Region: CCG; pfam02754 754252003973 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 754252003974 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 754252003975 glycerol-3-phosphate dehydrogenase, anaerobic, A subunit; Region: glycerol3P_GlpA; TIGR03377 754252003976 hydroxyglutarate oxidase; Provisional; Region: PRK11728 754252003977 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 754252003978 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 754252003979 active site 754252003980 nucleophile elbow; other site 754252003981 vitamin B12-dependent ribonucleotide reductase; Validated; Region: PRK06556 754252003982 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 754252003983 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 754252003984 active site 754252003985 dimer interface [polypeptide binding]; other site 754252003986 effector binding site; other site 754252003987 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 754252003988 TSCPD domain; Region: TSCPD; pfam12637 754252003989 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 754252003990 ATP cone domain; Region: ATP-cone; pfam03477 754252003991 LexA repressor; Validated; Region: PRK00215 754252003992 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 754252003993 putative DNA binding site [nucleotide binding]; other site 754252003994 putative Zn2+ binding site [ion binding]; other site 754252003995 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 754252003996 Catalytic site [active] 754252003997 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 754252003998 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 754252003999 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 754252004000 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 754252004001 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 754252004002 HflX GTPase family; Region: HflX; cd01878 754252004003 G1 box; other site 754252004004 GTP/Mg2+ binding site [chemical binding]; other site 754252004005 Switch I region; other site 754252004006 G2 box; other site 754252004007 G3 box; other site 754252004008 Switch II region; other site 754252004009 G4 box; other site 754252004010 G5 box; other site 754252004011 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 754252004012 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 754252004013 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 754252004014 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 754252004015 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 754252004016 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 754252004017 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 754252004018 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 754252004019 FeS/SAM binding site; other site 754252004020 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 754252004021 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 754252004022 Walker A/P-loop; other site 754252004023 ATP binding site [chemical binding]; other site 754252004024 Q-loop/lid; other site 754252004025 ABC transporter signature motif; other site 754252004026 Walker B; other site 754252004027 D-loop; other site 754252004028 H-loop/switch region; other site 754252004029 Domain of unknown function (DUF3552); Region: DUF3552; pfam12072 754252004030 KH domain; Region: KH_1; pfam00013 754252004031 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 754252004032 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 754252004033 Zn2+ binding site [ion binding]; other site 754252004034 Mg2+ binding site [ion binding]; other site 754252004035 recombination regulator RecX; Reviewed; Region: recX; PRK00117 754252004036 recombinase A; Provisional; Region: recA; PRK09354 754252004037 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 754252004038 hexamer interface [polypeptide binding]; other site 754252004039 Walker A motif; other site 754252004040 ATP binding site [chemical binding]; other site 754252004041 Walker B motif; other site 754252004042 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 754252004043 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 754252004044 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 754252004045 ATP binding site [chemical binding]; other site 754252004046 putative Mg++ binding site [ion binding]; other site 754252004047 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 754252004048 nucleotide binding region [chemical binding]; other site 754252004049 ATP-binding site [chemical binding]; other site 754252004050 DEAD/H associated; Region: DEAD_assoc; pfam08494 754252004051 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 754252004052 non-specific DNA binding site [nucleotide binding]; other site 754252004053 salt bridge; other site 754252004054 sequence-specific DNA binding site [nucleotide binding]; other site 754252004055 Competence-damaged protein; Region: CinA; pfam02464 754252004056 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 754252004057 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 754252004058 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 754252004059 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 754252004060 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 754252004061 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 754252004062 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 754252004063 thiamine monophosphate kinase; Provisional; Region: PRK05731 754252004064 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 754252004065 ATP binding site [chemical binding]; other site 754252004066 dimerization interface [polypeptide binding]; other site 754252004067 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 754252004068 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 754252004069 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 754252004070 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 754252004071 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 754252004072 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 754252004073 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 754252004074 putative acyl-acceptor binding pocket; other site 754252004075 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 754252004076 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 754252004077 substrate binding site [chemical binding]; other site 754252004078 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 754252004079 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 754252004080 substrate binding site [chemical binding]; other site 754252004081 ligand binding site [chemical binding]; other site 754252004082 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 754252004083 Transcriptional regulator [Transcription]; Region: IclR; COG1414 754252004084 Bacterial transcriptional regulator; Region: IclR; pfam01614 754252004085 CAAX protease self-immunity; Region: Abi; pfam02517 754252004086 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 754252004087 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 754252004088 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 754252004089 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 754252004090 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 754252004091 active site 754252004092 catalytic residues [active] 754252004093 metal binding site [ion binding]; metal-binding site 754252004094 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 754252004095 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 754252004096 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 754252004097 homodimer interface [polypeptide binding]; other site 754252004098 substrate-cofactor binding pocket; other site 754252004099 catalytic residue [active] 754252004100 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 754252004101 tartrate dehydrogenase; Region: TTC; TIGR02089 754252004102 ketol-acid reductoisomerase; Provisional; Region: PRK05479 754252004103 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 754252004104 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 754252004105 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 754252004106 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 754252004107 putative valine binding site [chemical binding]; other site 754252004108 dimer interface [polypeptide binding]; other site 754252004109 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 754252004110 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 754252004111 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 754252004112 PYR/PP interface [polypeptide binding]; other site 754252004113 dimer interface [polypeptide binding]; other site 754252004114 TPP binding site [chemical binding]; other site 754252004115 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 754252004116 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 754252004117 TPP-binding site [chemical binding]; other site 754252004118 dimer interface [polypeptide binding]; other site 754252004119 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 754252004120 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 754252004121 substrate binding site [chemical binding]; other site 754252004122 glutamase interaction surface [polypeptide binding]; other site 754252004123 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 754252004124 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 754252004125 active site 754252004126 catalytic tetrad [active] 754252004127 Uncharacterized conserved protein [Function unknown]; Region: COG1359 754252004128 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 754252004129 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 754252004130 ATP binding site [chemical binding]; other site 754252004131 putative Mg++ binding site [ion binding]; other site 754252004132 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 754252004133 nucleotide binding region [chemical binding]; other site 754252004134 ATP-binding site [chemical binding]; other site 754252004135 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 754252004136 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 754252004137 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 754252004138 active site 754252004139 motif I; other site 754252004140 motif II; other site 754252004141 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 754252004142 diacylglycerol kinase; Reviewed; Region: PRK11914 754252004143 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 754252004144 Transposase; Region: DDE_Tnp_ISL3; pfam01610 754252004145 diacylglycerol kinase; Reviewed; Region: PRK11914 754252004146 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 754252004147 Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902 754252004148 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 754252004149 Predicted transcriptional regulator [Transcription]; Region: COG2378 754252004150 WYL domain; Region: WYL; pfam13280 754252004151 Predicted transcriptional regulator [Transcription]; Region: COG2378 754252004152 WYL domain; Region: WYL; pfam13280 754252004153 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 754252004154 active site 754252004155 HIGH motif; other site 754252004156 nucleotide binding site [chemical binding]; other site 754252004157 active site 754252004158 KMSKS motif; other site 754252004159 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 754252004160 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 754252004161 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 754252004162 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 754252004163 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 754252004164 RNA binding surface [nucleotide binding]; other site 754252004165 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 754252004166 active site 754252004167 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 754252004168 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 754252004169 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 754252004170 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 754252004171 P loop; other site 754252004172 Nucleotide binding site [chemical binding]; other site 754252004173 DTAP/Switch II; other site 754252004174 Switch I; other site 754252004175 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 754252004176 Magnesium ion binding site [ion binding]; other site 754252004177 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 754252004178 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 754252004179 active site 754252004180 Int/Topo IB signature motif; other site 754252004181 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 754252004182 dimer interface [polypeptide binding]; other site 754252004183 ADP-ribose binding site [chemical binding]; other site 754252004184 active site 754252004185 nudix motif; other site 754252004186 metal binding site [ion binding]; metal-binding site 754252004187 CTP synthetase; Validated; Region: pyrG; PRK05380 754252004188 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 754252004189 Catalytic site [active] 754252004190 active site 754252004191 UTP binding site [chemical binding]; other site 754252004192 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 754252004193 active site 754252004194 putative oxyanion hole; other site 754252004195 catalytic triad [active] 754252004196 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 754252004197 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 754252004198 Walker A/P-loop; other site 754252004199 ATP binding site [chemical binding]; other site 754252004200 Q-loop/lid; other site 754252004201 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 754252004202 ABC transporter signature motif; other site 754252004203 Walker B; other site 754252004204 D-loop; other site 754252004205 H-loop/switch region; other site 754252004206 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 754252004207 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 754252004208 Cobalt transport protein; Region: CbiQ; cl00463 754252004209 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 754252004210 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 754252004211 Walker A/P-loop; other site 754252004212 ATP binding site [chemical binding]; other site 754252004213 Q-loop/lid; other site 754252004214 ABC transporter signature motif; other site 754252004215 Walker B; other site 754252004216 D-loop; other site 754252004217 H-loop/switch region; other site 754252004218 BioY family; Region: BioY; pfam02632 754252004219 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 754252004220 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 754252004221 active site 754252004222 motif I; other site 754252004223 motif II; other site 754252004224 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 754252004225 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 754252004226 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 754252004227 active site 754252004228 HIGH motif; other site 754252004229 dimer interface [polypeptide binding]; other site 754252004230 KMSKS motif; other site 754252004231 argininosuccinate lyase; Provisional; Region: PRK00855 754252004232 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 754252004233 active sites [active] 754252004234 tetramer interface [polypeptide binding]; other site 754252004235 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 754252004236 arginine repressor; Provisional; Region: PRK03341 754252004237 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 754252004238 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 754252004239 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 754252004240 inhibitor-cofactor binding pocket; inhibition site 754252004241 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754252004242 catalytic residue [active] 754252004243 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 754252004244 feedback inhibition sensing region; other site 754252004245 homohexameric interface [polypeptide binding]; other site 754252004246 nucleotide binding site [chemical binding]; other site 754252004247 N-acetyl-L-glutamate binding site [chemical binding]; other site 754252004248 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 754252004249 heterotetramer interface [polypeptide binding]; other site 754252004250 active site pocket [active] 754252004251 cleavage site 754252004252 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 754252004253 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 754252004254 aminotransferase AlaT; Validated; Region: PRK09265 754252004255 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 754252004256 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754252004257 homodimer interface [polypeptide binding]; other site 754252004258 catalytic residue [active] 754252004259 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 754252004260 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 754252004261 putative tRNA-binding site [nucleotide binding]; other site 754252004262 B3/4 domain; Region: B3_4; pfam03483 754252004263 tRNA synthetase B5 domain; Region: B5; pfam03484 754252004264 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 754252004265 dimer interface [polypeptide binding]; other site 754252004266 motif 1; other site 754252004267 motif 3; other site 754252004268 motif 2; other site 754252004269 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 754252004270 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 754252004271 phenylalanyl-tRNA synthetase, alpha subunit; Region: pheS; TIGR00468 754252004272 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 754252004273 dimer interface [polypeptide binding]; other site 754252004274 motif 1; other site 754252004275 active site 754252004276 motif 2; other site 754252004277 motif 3; other site 754252004278 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 754252004279 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 754252004280 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 754252004281 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 754252004282 23S rRNA binding site [nucleotide binding]; other site 754252004283 L21 binding site [polypeptide binding]; other site 754252004284 L13 binding site [polypeptide binding]; other site 754252004285 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 754252004286 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 754252004287 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 754252004288 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 754252004289 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 754252004290 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 754252004291 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 754252004292 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 754252004293 homodimer interface [polypeptide binding]; other site 754252004294 putative metal binding site [ion binding]; other site 754252004295 FtsH Extracellular; Region: FtsH_ext; pfam06480 754252004296 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 754252004297 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 754252004298 Walker A motif; other site 754252004299 ATP binding site [chemical binding]; other site 754252004300 Walker B motif; other site 754252004301 arginine finger; other site 754252004302 Peptidase family M41; Region: Peptidase_M41; pfam01434 754252004303 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 754252004304 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 754252004305 active site 754252004306 HIGH motif; other site 754252004307 nucleotide binding site [chemical binding]; other site 754252004308 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 754252004309 active site 754252004310 KMSKS motif; other site 754252004311 Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955 754252004312 putative tRNA binding surface [nucleotide binding]; other site 754252004313 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 754252004314 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 754252004315 active site 754252004316 catalytic tetrad [active] 754252004317 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 754252004318 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cl00252 754252004319 tryptophan synthase subunit beta; Reviewed; Region: PRK12391 754252004320 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 754252004321 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 754252004322 catalytic residue [active] 754252004323 DNA protecting protein DprA; Region: dprA; TIGR00732 754252004324 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 754252004325 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 754252004326 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 754252004327 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 754252004328 Walker A motif; other site 754252004329 ATP binding site [chemical binding]; other site 754252004330 Walker B motif; other site 754252004331 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 754252004332 hypothetical protein; Reviewed; Region: PRK12497 754252004333 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 754252004334 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 754252004335 RNA/DNA hybrid binding site [nucleotide binding]; other site 754252004336 active site 754252004337 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 754252004338 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 754252004339 Catalytic site [active] 754252004340 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 754252004341 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 754252004342 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 754252004343 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 754252004344 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 754252004345 L-aspartate oxidase; Provisional; Region: PRK06175 754252004346 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 754252004347 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 754252004348 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 754252004349 putative Iron-sulfur protein interface [polypeptide binding]; other site 754252004350 proximal heme binding site [chemical binding]; other site 754252004351 distal heme binding site [chemical binding]; other site 754252004352 putative dimer interface [polypeptide binding]; other site 754252004353 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 754252004354 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 754252004355 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 754252004356 RimM N-terminal domain; Region: RimM; pfam01782 754252004357 PRC-barrel domain; Region: PRC; pfam05239 754252004358 hypothetical protein; Provisional; Region: PRK02821 754252004359 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 754252004360 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 754252004361 Amidohydrolase; Region: Amidohydro_4; pfam13147 754252004362 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 754252004363 active site 754252004364 signal recognition particle protein; Provisional; Region: PRK10867 754252004365 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 754252004366 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 754252004367 P loop; other site 754252004368 GTP binding site [chemical binding]; other site 754252004369 Signal peptide binding domain; Region: SRP_SPB; pfam02978 754252004370 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 754252004371 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 754252004372 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 754252004373 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 754252004374 AAA domain; Region: AAA_23; pfam13476 754252004375 Walker A/P-loop; other site 754252004376 ATP binding site [chemical binding]; other site 754252004377 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 754252004378 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470 754252004379 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 754252004380 ABC transporter signature motif; other site 754252004381 Walker B; other site 754252004382 D-loop; other site 754252004383 H-loop/switch region; other site 754252004384 Predicted membrane protein [Function unknown]; Region: COG2246 754252004385 GtrA-like protein; Region: GtrA; pfam04138 754252004386 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 754252004387 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 754252004388 DNA binding site [nucleotide binding] 754252004389 catalytic residue [active] 754252004390 H2TH interface [polypeptide binding]; other site 754252004391 putative catalytic residues [active] 754252004392 turnover-facilitating residue; other site 754252004393 intercalation triad [nucleotide binding]; other site 754252004394 8OG recognition residue [nucleotide binding]; other site 754252004395 putative reading head residues; other site 754252004396 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 754252004397 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 754252004398 ribonuclease III; Reviewed; Region: rnc; PRK00102 754252004399 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 754252004400 dimerization interface [polypeptide binding]; other site 754252004401 active site 754252004402 metal binding site [ion binding]; metal-binding site 754252004403 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 754252004404 dsRNA binding site [nucleotide binding]; other site 754252004405 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 754252004406 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 754252004407 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 754252004408 active site 754252004409 (T/H)XGH motif; other site 754252004410 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 754252004411 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 754252004412 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 754252004413 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 754252004414 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 754252004415 ssDNA binding site; other site 754252004416 generic binding surface II; other site 754252004417 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 754252004418 ATP binding site [chemical binding]; other site 754252004419 putative Mg++ binding site [ion binding]; other site 754252004420 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 754252004421 nucleotide binding region [chemical binding]; other site 754252004422 ATP-binding site [chemical binding]; other site 754252004423 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 754252004424 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 754252004425 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 754252004426 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 754252004427 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 754252004428 Coenzyme A binding pocket [chemical binding]; other site 754252004429 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 754252004430 dihydrodipicolinate reductase; Provisional; Region: PRK00048 754252004431 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 754252004432 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 754252004433 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 754252004434 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 754252004435 oligomer interface [polypeptide binding]; other site 754252004436 RNA binding site [nucleotide binding]; other site 754252004437 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 754252004438 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 754252004439 oligomer interface [polypeptide binding]; other site 754252004440 RNA binding site [nucleotide binding]; other site 754252004441 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 754252004442 putative nucleic acid binding region [nucleotide binding]; other site 754252004443 G-X-X-G motif; other site 754252004444 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 754252004445 RNA binding site [nucleotide binding]; other site 754252004446 domain interface; other site 754252004447 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 754252004448 16S/18S rRNA binding site [nucleotide binding]; other site 754252004449 S13e-L30e interaction site [polypeptide binding]; other site 754252004450 25S rRNA binding site [nucleotide binding]; other site 754252004451 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 754252004452 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 754252004453 active site 754252004454 Riboflavin kinase; Region: Flavokinase; smart00904 754252004455 glycerol kinase; Provisional; Region: glpK; PRK00047 754252004456 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 754252004457 N- and C-terminal domain interface [polypeptide binding]; other site 754252004458 active site 754252004459 MgATP binding site [chemical binding]; other site 754252004460 catalytic site [active] 754252004461 metal binding site [ion binding]; metal-binding site 754252004462 putative homotetramer interface [polypeptide binding]; other site 754252004463 glycerol binding site [chemical binding]; other site 754252004464 homodimer interface [polypeptide binding]; other site 754252004465 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 754252004466 amphipathic channel; other site 754252004467 Asn-Pro-Ala signature motifs; other site 754252004468 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 754252004469 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 754252004470 RNA binding site [nucleotide binding]; other site 754252004471 active site 754252004472 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 754252004473 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 754252004474 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 754252004475 translation initiation factor IF-2; Region: IF-2; TIGR00487 754252004476 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 754252004477 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 754252004478 G1 box; other site 754252004479 putative GEF interaction site [polypeptide binding]; other site 754252004480 GTP/Mg2+ binding site [chemical binding]; other site 754252004481 Switch I region; other site 754252004482 G2 box; other site 754252004483 G3 box; other site 754252004484 Switch II region; other site 754252004485 G4 box; other site 754252004486 G5 box; other site 754252004487 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 754252004488 Translation-initiation factor 2; Region: IF-2; pfam11987 754252004489 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 754252004490 Protein of unknown function (DUF448); Region: DUF448; pfam04296 754252004491 putative RNA binding cleft [nucleotide binding]; other site 754252004492 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 754252004493 NusA N-terminal domain; Region: NusA_N; pfam08529 754252004494 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 754252004495 RNA binding site [nucleotide binding]; other site 754252004496 homodimer interface [polypeptide binding]; other site 754252004497 NusA-like KH domain; Region: KH_5; pfam13184 754252004498 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 754252004499 G-X-X-G motif; other site 754252004500 ribosome maturation protein RimP; Reviewed; Region: PRK00092 754252004501 Sm and related proteins; Region: Sm_like; cl00259 754252004502 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 754252004503 putative oligomer interface [polypeptide binding]; other site 754252004504 putative RNA binding site [nucleotide binding]; other site 754252004505 prolyl-tRNA synthetase; Provisional; Region: PRK09194 754252004506 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 754252004507 dimer interface [polypeptide binding]; other site 754252004508 motif 1; other site 754252004509 active site 754252004510 motif 2; other site 754252004511 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 754252004512 putative deacylase active site [active] 754252004513 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 754252004514 active site 754252004515 motif 3; other site 754252004516 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 754252004517 anticodon binding site; other site 754252004518 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 754252004519 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 754252004520 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 754252004521 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 754252004522 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 754252004523 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 754252004524 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 754252004525 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 754252004526 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 754252004527 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 754252004528 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 754252004529 FeS/SAM binding site; other site 754252004530 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 754252004531 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 754252004532 ribosome recycling factor; Reviewed; Region: frr; PRK00083 754252004533 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 754252004534 hinge region; other site 754252004535 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 754252004536 putative nucleotide binding site [chemical binding]; other site 754252004537 uridine monophosphate binding site [chemical binding]; other site 754252004538 homohexameric interface [polypeptide binding]; other site 754252004539 elongation factor Ts; Provisional; Region: tsf; PRK09377 754252004540 UBA/TS-N domain; Region: UBA; pfam00627 754252004541 Elongation factor TS; Region: EF_TS; pfam00889 754252004542 Elongation factor TS; Region: EF_TS; pfam00889 754252004543 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 754252004544 rRNA interaction site [nucleotide binding]; other site 754252004545 S8 interaction site; other site 754252004546 putative laminin-1 binding site; other site 754252004547 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 754252004548 Peptidase family M23; Region: Peptidase_M23; pfam01551 754252004549 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 754252004550 Peptidase family M23; Region: Peptidase_M23; pfam01551 754252004551 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 754252004552 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 754252004553 active site 754252004554 DNA binding site [nucleotide binding] 754252004555 Int/Topo IB signature motif; other site 754252004556 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 754252004557 active site 754252004558 catalytic residues [active] 754252004559 metal binding site [ion binding]; metal-binding site 754252004560 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 754252004561 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 754252004562 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 754252004563 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 754252004564 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 754252004565 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754252004566 Walker A/P-loop; other site 754252004567 ATP binding site [chemical binding]; other site 754252004568 Q-loop/lid; other site 754252004569 ABC transporter signature motif; other site 754252004570 Walker B; other site 754252004571 D-loop; other site 754252004572 H-loop/switch region; other site 754252004573 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 754252004574 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 754252004575 NAD(P) binding site [chemical binding]; other site 754252004576 active site 754252004577 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 754252004578 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 754252004579 NAD(P) binding site [chemical binding]; other site 754252004580 active site 754252004581 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 754252004582 NAD(P) binding site [chemical binding]; other site 754252004583 active site 754252004584 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 754252004585 Methyltransferase domain; Region: Methyltransf_11; pfam08241 754252004586 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 754252004587 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 754252004588 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754252004589 Walker A/P-loop; other site 754252004590 ATP binding site [chemical binding]; other site 754252004591 Q-loop/lid; other site 754252004592 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 754252004593 ABC transporter signature motif; other site 754252004594 Walker B; other site 754252004595 D-loop; other site 754252004596 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 754252004597 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 754252004598 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 754252004599 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 754252004600 trimerization site [polypeptide binding]; other site 754252004601 active site 754252004602 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 754252004603 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 754252004604 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 754252004605 catalytic residue [active] 754252004606 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 754252004607 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 754252004608 Walker A/P-loop; other site 754252004609 ATP binding site [chemical binding]; other site 754252004610 Q-loop/lid; other site 754252004611 ABC transporter signature motif; other site 754252004612 Walker B; other site 754252004613 D-loop; other site 754252004614 H-loop/switch region; other site 754252004615 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 754252004616 [2Fe-2S] cluster binding site [ion binding]; other site 754252004617 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 754252004618 FeS assembly protein SufD; Region: sufD; TIGR01981 754252004619 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 754252004620 FeS assembly protein SufB; Region: sufB; TIGR01980 754252004621 Predicted transcriptional regulator [Transcription]; Region: COG2345 754252004622 putative DNA binding site [nucleotide binding]; other site 754252004623 Helix-turn-helix domain; Region: HTH_20; pfam12840 754252004624 putative Zn2+ binding site [ion binding]; other site 754252004625 Predicted transcriptional regulators [Transcription]; Region: COG1725 754252004626 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 754252004627 DNA-binding site [nucleotide binding]; DNA binding site 754252004628 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 754252004629 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 754252004630 Walker A/P-loop; other site 754252004631 ATP binding site [chemical binding]; other site 754252004632 Q-loop/lid; other site 754252004633 ABC transporter signature motif; other site 754252004634 Walker B; other site 754252004635 D-loop; other site 754252004636 H-loop/switch region; other site 754252004637 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 754252004638 predicted active site [active] 754252004639 catalytic triad [active] 754252004640 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 754252004641 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 754252004642 active site 754252004643 multimer interface [polypeptide binding]; other site 754252004644 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 754252004645 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 754252004646 DNA-binding site [nucleotide binding]; DNA binding site 754252004647 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 754252004648 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 754252004649 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 754252004650 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 754252004651 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 754252004652 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 754252004653 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 754252004654 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 754252004655 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 754252004656 putative active site [active] 754252004657 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 754252004658 triosephosphate isomerase; Provisional; Region: PRK14567 754252004659 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 754252004660 substrate binding site [chemical binding]; other site 754252004661 dimer interface [polypeptide binding]; other site 754252004662 catalytic triad [active] 754252004663 Phosphoglycerate kinase; Region: PGK; pfam00162 754252004664 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 754252004665 substrate binding site [chemical binding]; other site 754252004666 hinge regions; other site 754252004667 ADP binding site [chemical binding]; other site 754252004668 catalytic site [active] 754252004669 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 754252004670 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 754252004671 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 754252004673 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 754252004674 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 754252004675 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 754252004676 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 754252004677 putative substrate binding pocket [chemical binding]; other site 754252004678 dimer interface [polypeptide binding]; other site 754252004679 phosphate binding site [ion binding]; other site 754252004680 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 754252004681 shikimate kinase; Reviewed; Region: aroK; PRK00131 754252004682 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 754252004683 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 754252004684 GIY-YIG motif/motif A; other site 754252004685 active site 754252004686 catalytic site [active] 754252004687 putative DNA binding site [nucleotide binding]; other site 754252004688 metal binding site [ion binding]; metal-binding site 754252004689 UvrB/uvrC motif; Region: UVR; pfam02151 754252004690 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 754252004691 Helix-hairpin-helix motif; Region: HHH; pfam00633 754252004692 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 754252004693 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 754252004694 Histidine kinase; Region: HisKA_3; pfam07730 754252004695 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 754252004696 ATP binding site [chemical binding]; other site 754252004697 Mg2+ binding site [ion binding]; other site 754252004698 G-X-G motif; other site 754252004699 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 754252004700 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754252004701 active site 754252004702 phosphorylation site [posttranslational modification] 754252004703 intermolecular recognition site; other site 754252004704 dimerization interface [polypeptide binding]; other site 754252004705 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 754252004706 DNA binding residues [nucleotide binding] 754252004707 dimerization interface [polypeptide binding]; other site 754252004708 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 754252004709 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754252004710 Walker A/P-loop; other site 754252004711 ATP binding site [chemical binding]; other site 754252004712 Q-loop/lid; other site 754252004713 ABC transporter signature motif; other site 754252004714 Walker B; other site 754252004715 D-loop; other site 754252004716 H-loop/switch region; other site 754252004717 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 754252004718 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 754252004719 ABC-2 type transporter; Region: ABC2_membrane; cl17235 754252004720 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 754252004721 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 754252004722 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 754252004723 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 754252004724 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 754252004725 mycothiol-dependent maleylpyruvate isomerase; Reviewed; Region: PRK09583 754252004726 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 754252004727 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 754252004728 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 754252004729 excinuclease ABC subunit B; Provisional; Region: PRK05298 754252004730 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 754252004731 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 754252004732 nucleotide binding region [chemical binding]; other site 754252004733 ATP-binding site [chemical binding]; other site 754252004734 Ultra-violet resistance protein B; Region: UvrB; pfam12344 754252004735 UvrB/uvrC motif; Region: UVR; pfam02151 754252004736 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 754252004737 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 754252004738 CoA-binding site [chemical binding]; other site 754252004739 ATP-binding [chemical binding]; other site 754252004740 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 754252004741 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 754252004742 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 754252004743 RNA binding site [nucleotide binding]; other site 754252004744 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 754252004745 RNA binding site [nucleotide binding]; other site 754252004746 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 754252004747 RNA binding site [nucleotide binding]; other site 754252004748 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 754252004749 RNA binding site [nucleotide binding]; other site 754252004750 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 754252004751 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 754252004752 tetramerization interface [polypeptide binding]; other site 754252004753 NAD(P) binding site [chemical binding]; other site 754252004754 catalytic residues [active] 754252004755 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 754252004756 active site 754252004757 catalytic site [active] 754252004758 DNA polymerase I; Provisional; Region: PRK05755 754252004759 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 754252004760 active site 754252004761 metal binding site 1 [ion binding]; metal-binding site 754252004762 putative 5' ssDNA interaction site; other site 754252004763 metal binding site 3; metal-binding site 754252004764 metal binding site 2 [ion binding]; metal-binding site 754252004765 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 754252004766 putative DNA binding site [nucleotide binding]; other site 754252004767 putative metal binding site [ion binding]; other site 754252004768 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 754252004769 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 754252004770 active site 754252004771 DNA binding site [nucleotide binding] 754252004772 catalytic site [active] 754252004773 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 754252004774 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754252004775 active site 754252004776 phosphorylation site [posttranslational modification] 754252004777 intermolecular recognition site; other site 754252004778 dimerization interface [polypeptide binding]; other site 754252004779 ANTAR domain; Region: ANTAR; pfam03861 754252004780 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 754252004781 pyruvate kinase; Provisional; Region: PRK06247 754252004782 domain interfaces; other site 754252004783 active site 754252004784 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 754252004785 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 754252004786 RNA binding surface [nucleotide binding]; other site 754252004787 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 754252004788 active site 754252004789 Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252 754252004790 lipoprotein signal peptidase; Provisional; Region: PRK14787 754252004791 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 754252004792 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 754252004793 Protein of unknown function (DUF552); Region: DUF552; cl00775 754252004794 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 754252004795 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 754252004796 cell division protein FtsZ; Region: ftsZ; TIGR00065 754252004797 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 754252004798 nucleotide binding site [chemical binding]; other site 754252004799 SulA interaction site; other site 754252004800 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 754252004801 Cell division protein FtsQ; Region: FtsQ; pfam03799 754252004802 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 754252004803 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 754252004804 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 754252004805 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 754252004806 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 754252004807 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 754252004808 active site 754252004809 homodimer interface [polypeptide binding]; other site 754252004810 cell division protein FtsW; Region: ftsW; TIGR02614 754252004811 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438 754252004812 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 754252004813 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 754252004814 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 754252004815 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 754252004816 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 754252004817 Mg++ binding site [ion binding]; other site 754252004818 putative catalytic motif [active] 754252004819 putative substrate binding site [chemical binding]; other site 754252004820 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 754252004821 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 754252004822 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 754252004823 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 754252004824 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 754252004825 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 754252004826 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 754252004827 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 754252004828 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 754252004829 MraW methylase family; Region: Methyltransf_5; cl17771 754252004830 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 754252004831 cell division protein MraZ; Reviewed; Region: PRK00326 754252004832 MraZ protein; Region: MraZ; pfam02381 754252004833 MraZ protein; Region: MraZ; pfam02381 754252004834 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 754252004835 DNA polymerase IV; Validated; Region: PRK03858 754252004836 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 754252004837 active site 754252004838 DNA binding site [nucleotide binding] 754252004839 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 754252004840 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 754252004841 active site 754252004842 PHP Thumb interface [polypeptide binding]; other site 754252004843 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 754252004844 generic binding surface II; other site 754252004845 generic binding surface I; other site 754252004846 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 754252004847 Part of AAA domain; Region: AAA_19; pfam13245 754252004848 Family description; Region: UvrD_C_2; pfam13538 754252004849 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 754252004850 FAD binding site [chemical binding]; other site 754252004851 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 754252004852 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 754252004853 substrate binding pocket [chemical binding]; other site 754252004854 chain length determination region; other site 754252004855 substrate-Mg2+ binding site; other site 754252004856 catalytic residues [active] 754252004857 aspartate-rich region 1; other site 754252004858 active site lid residues [active] 754252004859 aspartate-rich region 2; other site 754252004860 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 754252004861 Catalytic domain of Protein Kinases; Region: PKc; cd00180 754252004862 active site 754252004863 ATP binding site [chemical binding]; other site 754252004864 substrate binding site [chemical binding]; other site 754252004865 activation loop (A-loop); other site 754252004866 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 754252004867 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 754252004868 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 754252004869 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 754252004870 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 754252004871 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 754252004872 EamA-like transporter family; Region: EamA; pfam00892 754252004873 EamA-like transporter family; Region: EamA; pfam00892 754252004874 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 754252004875 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 754252004876 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 754252004877 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 754252004878 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 754252004879 putative acyl-acceptor binding pocket; other site 754252004880 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 754252004881 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 754252004882 putative acyl-acceptor binding pocket; other site 754252004883 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 754252004884 Peptidase family M23; Region: Peptidase_M23; pfam01551 754252004885 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 754252004886 AsnC family; Region: AsnC_trans_reg; pfam01037 754252004887 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 754252004888 active site 754252004889 Apolipoprotein A1/A4/E domain; Region: Apolipoprotein; pfam01442 754252004890 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 754252004891 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 754252004892 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 754252004893 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Deinococcus radiodurans DR2231 protein and its bacterial homologs; Region: NTP-PPase_DR2231_like; cd11530 754252004894 metal binding site [ion binding]; metal-binding site 754252004895 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 754252004896 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 754252004897 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 754252004898 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 754252004899 active site 754252004900 phosphorylation site [posttranslational modification] 754252004901 intermolecular recognition site; other site 754252004902 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 754252004903 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 754252004904 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 754252004905 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 754252004906 phosphate binding site [ion binding]; other site 754252004907 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 754252004908 Glycerate kinase family; Region: Gly_kinase; cl00841 754252004909 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 754252004910 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 754252004911 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 754252004912 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 754252004913 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 754252004914 E3 interaction surface; other site 754252004915 lipoyl attachment site [posttranslational modification]; other site 754252004916 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 754252004917 E3 interaction surface; other site 754252004918 lipoyl attachment site [posttranslational modification]; other site 754252004919 e3 binding domain; Region: E3_binding; pfam02817 754252004920 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 754252004921 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 754252004922 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 754252004923 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 754252004924 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 754252004925 ABC transporter; Region: ABC_tran_2; pfam12848 754252004926 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754252004927 Walker A/P-loop; other site 754252004928 ATP binding site [chemical binding]; other site 754252004929 ABC transporter signature motif; other site 754252004930 Walker B; other site 754252004931 D-loop; other site 754252004932 H-loop/switch region; other site 754252004933 glutamine synthetase, type I; Region: GlnA; TIGR00653 754252004934 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 754252004935 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 754252004936 tetracycline repressor protein TetR; Provisional; Region: PRK13756 754252004937 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 754252004938 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 754252004939 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 754252004940 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 754252004941 active site 754252004942 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 754252004943 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 754252004944 metal binding triad; other site 754252004945 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 754252004946 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 754252004947 metal binding triad; other site 754252004948 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 754252004949 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 754252004950 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 754252004951 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 754252004952 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 754252004953 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 754252004954 active site 754252004955 S-layer homology domain; Region: SLH; pfam00395 754252004956 S-layer homology domain; Region: SLH; pfam00395 754252004957 S-layer homology domain; Region: SLH; pfam00395 754252004958 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 754252004959 Putative zinc ribbon domain; Region: DUF164; pfam02591 754252004960 proline aminopeptidase P II; Provisional; Region: PRK10879 754252004961 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 754252004962 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 754252004963 active site 754252004964 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 754252004965 PRC-barrel domain; Region: PRC; pfam05239 754252004966 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 754252004967 MgtE intracellular N domain; Region: MgtE_N; pfam03448 754252004968 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 754252004969 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 754252004970 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 754252004971 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 754252004972 sec-independent translocase; Provisional; Region: PRK01371 754252004973 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 754252004974 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 754252004975 dimer interface [polypeptide binding]; other site 754252004976 active site 754252004977 catalytic residue [active] 754252004978 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 754252004979 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754252004980 S-adenosylmethionine binding site [chemical binding]; other site 754252004981 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 754252004982 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 754252004983 ligand binding site; other site 754252004984 oligomer interface; other site 754252004985 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 754252004986 dimer interface [polypeptide binding]; other site 754252004987 N-terminal domain interface [polypeptide binding]; other site 754252004988 sulfate 1 binding site; other site 754252004989 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 754252004990 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 754252004991 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 754252004992 DivIVA domain; Region: DivI1A_domain; TIGR03544 754252004993 DivIVA domain; Region: DivI1A_domain; TIGR03544 754252004994 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 754252004995 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 754252004996 Cl- selectivity filter; other site 754252004997 Cl- binding residues [ion binding]; other site 754252004998 pore gating glutamate residue; other site 754252004999 dimer interface [polypeptide binding]; other site 754252005000 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 754252005001 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 754252005002 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 754252005003 metal binding site [ion binding]; metal-binding site 754252005004 putative dimer interface [polypeptide binding]; other site 754252005005 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 754252005006 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 754252005007 putative trimer interface [polypeptide binding]; other site 754252005008 putative CoA binding site [chemical binding]; other site 754252005009 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 754252005010 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 754252005011 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754252005012 homodimer interface [polypeptide binding]; other site 754252005013 catalytic residue [active] 754252005014 Ferredoxin [Energy production and conversion]; Region: COG1146 754252005015 4Fe-4S binding domain; Region: Fer4; pfam00037 754252005016 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 754252005017 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 754252005018 dimerization interface [polypeptide binding]; other site 754252005019 ligand binding site [chemical binding]; other site 754252005020 NADP binding site [chemical binding]; other site 754252005021 catalytic site [active] 754252005022 fumarate hydratase; Reviewed; Region: fumC; PRK00485 754252005023 Class II fumarases; Region: Fumarase_classII; cd01362 754252005024 active site 754252005025 tetramer interface [polypeptide binding]; other site 754252005026 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 754252005027 Aspartase; Region: Aspartase; cd01357 754252005028 active sites [active] 754252005029 tetramer interface [polypeptide binding]; other site 754252005030 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 754252005031 Aspartase; Region: Aspartase; cd01357 754252005032 active sites [active] 754252005033 tetramer interface [polypeptide binding]; other site 754252005034 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 754252005035 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 754252005036 putative transposase OrfB; Reviewed; Region: PHA02517 754252005037 HTH-like domain; Region: HTH_21; pfam13276 754252005038 Integrase core domain; Region: rve; pfam00665 754252005039 Integrase core domain; Region: rve_3; pfam13683 754252005040 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 754252005041 DNA-binding interface [nucleotide binding]; DNA binding site 754252005042 H+ Antiporter protein; Region: 2A0121; TIGR00900 754252005043 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754252005044 putative substrate translocation pore; other site 754252005045 MarR family; Region: MarR; pfam01047 754252005046 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 754252005047 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 754252005048 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 754252005049 Coenzyme A binding pocket [chemical binding]; other site 754252005050 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 754252005051 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 754252005052 active site 754252005053 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 754252005054 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 754252005055 metal binding site [ion binding]; metal-binding site 754252005056 dimer interface [polypeptide binding]; other site 754252005057 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 754252005058 Diacylglycerol kinase accessory domain; Region: DAGK_acc; cl02440 754252005059 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 754252005060 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 754252005061 dimer interface [polypeptide binding]; other site 754252005062 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754252005063 catalytic residue [active] 754252005064 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 754252005065 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 754252005066 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 754252005067 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 754252005068 Peptidyl-tRNA hydrolase, type 2 (PTH2)_like . Peptidyl-tRNA hydrolase activity releases tRNA from the premature translation termination product peptidyl-tRNA. Two structurally different enzymes have been reported to encode such activity, Pth present in...; Region: PTH2_family; cl00869 754252005069 dimer interface [polypeptide binding]; other site 754252005070 putative active site [active] 754252005071 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 754252005072 dimer interface [polypeptide binding]; other site 754252005073 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 754252005074 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 754252005075 dimer interface [polypeptide binding]; other site 754252005076 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 754252005077 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754252005078 putative substrate translocation pore; other site 754252005079 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 754252005080 carbon starvation protein A; Provisional; Region: PRK15015 754252005081 Carbon starvation protein CstA; Region: CstA; pfam02554 754252005082 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 754252005083 Protein of unknown function (DUF466); Region: DUF466; cl01082 754252005084 Transcriptional regulator [Transcription]; Region: LysR; COG0583 754252005085 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754252005086 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 754252005087 putative dimerization interface [polypeptide binding]; other site 754252005088 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 754252005089 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 754252005090 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 754252005091 ATP binding site [chemical binding]; other site 754252005092 substrate interface [chemical binding]; other site 754252005093 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 754252005094 active site residue [active] 754252005095 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 754252005096 ThiS interaction site; other site 754252005097 putative active site [active] 754252005098 tetramer interface [polypeptide binding]; other site 754252005099 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 754252005100 thiS-thiF/thiG interaction site; other site 754252005101 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 754252005102 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 754252005103 active site 754252005104 thiamine phosphate binding site [chemical binding]; other site 754252005105 pyrophosphate binding site [ion binding]; other site 754252005106 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 754252005107 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 754252005108 sn-glycerol 3-phosphate + FAD <=> glycerone phosphate + FADH2 and sn-glycerol 3-phosphate + Acceptor <=> glycerone phosphate + Reduced acceptor 754252005109 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 754252005110 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 754252005111 Transposase; Region: DDE_Tnp_ISL3; pfam01610 754252005113 putative transposase OrfB; Reviewed; Region: PHA02517 754252005114 HTH-like domain; Region: HTH_21; pfam13276 754252005115 Integrase core domain; Region: rve; pfam00665 754252005116 Integrase core domain; Region: rve_3; pfam13683 754252005117 Transposase; Region: HTH_Tnp_1; pfam01527 754252005118 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 754252005119 sn-glycerol 3-phosphate + FAD <=> glycerone phosphate + FADH2 and sn-glycerol 3-phosphate + Acceptor <=> glycerone phosphate + Reduced acceptor 754252005120 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 754252005121 FAD binding domain; Region: FAD_binding_4; pfam01565 754252005122 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 754252005123 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 754252005124 Transposase; Region: DDE_Tnp_ISL3; pfam01610 754252005125 D-lactate dehydrogenase; Provisional; Region: PRK11183 754252005126 FAD binding domain; Region: FAD_binding_4; pfam01565 754252005127 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 754252005128 Helix-turn-helix domain; Region: HTH_28; pfam13518 754252005129 Winged helix-turn helix; Region: HTH_29; pfam13551 754252005131 Integrase core domain; Region: rve_3; pfam13683 754252005132 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 754252005133 Helix-turn-helix domain; Region: HTH_38; pfam13936 754252005134 Integrase core domain; Region: rve; pfam00665 754252005135 Integrase core domain; Region: rve; pfam00665 754252005136 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 754252005137 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 754252005138 Helix-turn-helix domain; Region: HTH_17; cl17695 754252005139 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 754252005140 Transposase; Region: DDE_Tnp_ISL3; pfam01610 754252005141 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 754252005142 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 754252005143 catalytic residues [active] 754252005144 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 754252005145 Transcriptional regulator [Transcription]; Region: LysR; COG0583 754252005146 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754252005147 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 754252005148 dimerization interface [polypeptide binding]; other site 754252005149 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 754252005150 dimerization interface [polypeptide binding]; other site 754252005151 putative DNA binding site [nucleotide binding]; other site 754252005152 putative Zn2+ binding site [ion binding]; other site 754252005153 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 754252005154 Peptidase family M23; Region: Peptidase_M23; pfam01551 754252005155 Uncharacterized conserved protein [Function unknown]; Region: COG1479 754252005156 Protein of unknown function DUF262; Region: DUF262; pfam03235 754252005157 GTP-binding protein YchF; Reviewed; Region: PRK09601 754252005158 YchF GTPase; Region: YchF; cd01900 754252005159 G1 box; other site 754252005160 GTP/Mg2+ binding site [chemical binding]; other site 754252005161 Switch I region; other site 754252005162 G2 box; other site 754252005163 Switch II region; other site 754252005164 G3 box; other site 754252005165 G4 box; other site 754252005166 G5 box; other site 754252005167 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 754252005168 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 754252005169 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 754252005170 active site 754252005171 metal binding site [ion binding]; metal-binding site 754252005172 RmuC family; Region: RmuC; pfam02646 754252005173 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 754252005174 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 754252005175 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 754252005176 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 754252005177 generic binding surface II; other site 754252005178 generic binding surface I; other site 754252005179 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 754252005180 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 754252005181 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 754252005182 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 754252005183 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 754252005184 catalytic residue [active] 754252005185 putative FPP diphosphate binding site; other site 754252005186 putative FPP binding hydrophobic cleft; other site 754252005187 dimer interface [polypeptide binding]; other site 754252005188 putative IPP diphosphate binding site; other site 754252005189 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 754252005190 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 754252005191 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 754252005192 catalytic residues [active] 754252005193 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 754252005194 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 754252005195 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 754252005196 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 754252005197 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 754252005198 Predicted membrane protein [Function unknown]; Region: COG2259 754252005199 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 754252005200 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 754252005201 ligand binding site [chemical binding]; other site 754252005202 active site 754252005203 UGI interface [polypeptide binding]; other site 754252005204 catalytic site [active] 754252005205 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 754252005206 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 754252005207 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 754252005208 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 754252005209 motif II; other site 754252005210 DinB superfamily; Region: DinB_2; pfam12867 754252005211 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 754252005212 hydrophobic ligand binding site; other site 754252005213 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 754252005214 active site 754252005215 DNA binding site [nucleotide binding] 754252005216 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 754252005217 nudix motif; other site 754252005218 Bax inhibitor 1 like; Region: BaxI_1; cl17691 754252005219 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754252005220 S-adenosylmethionine binding site [chemical binding]; other site 754252005221 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 754252005222 NADH(P)-binding; Region: NAD_binding_10; pfam13460 754252005223 NAD(P) binding site [chemical binding]; other site 754252005224 putative active site [active] 754252005225 Amino acid permease; Region: AA_permease_2; pfam13520 754252005226 enolase; Provisional; Region: eno; PRK00077 754252005227 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 754252005228 dimer interface [polypeptide binding]; other site 754252005229 metal binding site [ion binding]; metal-binding site 754252005230 substrate binding pocket [chemical binding]; other site 754252005231 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 754252005232 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 754252005233 Major Facilitator Superfamily; Region: MFS_1; pfam07690 754252005234 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754252005235 putative substrate translocation pore; other site 754252005236 exopolyphosphatase; Region: exo_poly_only; TIGR03706 754252005237 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 754252005238 Protein of unknown function (DUF501); Region: DUF501; pfam04417 754252005239 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 754252005240 Septum formation initiator; Region: DivIC; pfam04977 754252005241 enolase; Provisional; Region: eno; PRK00077 754252005242 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 754252005243 dimer interface [polypeptide binding]; other site 754252005244 metal binding site [ion binding]; metal-binding site 754252005245 substrate binding pocket [chemical binding]; other site 754252005246 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334 754252005247 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 754252005248 homodimer interface [polypeptide binding]; other site 754252005249 metal binding site [ion binding]; metal-binding site 754252005250 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 754252005251 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 754252005252 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 754252005253 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 754252005254 ATP binding site [chemical binding]; other site 754252005255 putative Mg++ binding site [ion binding]; other site 754252005256 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 754252005257 nucleotide binding region [chemical binding]; other site 754252005258 ATP-binding site [chemical binding]; other site 754252005259 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 754252005260 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 754252005261 putative active site [active] 754252005262 catalytic residue [active] 754252005263 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 754252005264 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 754252005265 5S rRNA interface [nucleotide binding]; other site 754252005266 CTC domain interface [polypeptide binding]; other site 754252005267 L16 interface [polypeptide binding]; other site 754252005268 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 754252005269 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 754252005270 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 754252005271 active site 754252005272 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 754252005273 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 754252005274 Substrate binding site; other site 754252005275 Mg++ binding site; other site 754252005276 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 754252005277 active site 754252005278 substrate binding site [chemical binding]; other site 754252005279 CoA binding site [chemical binding]; other site 754252005280 aspartate carbamoyltransferase; Provisional; Region: PRK08192 754252005281 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 754252005282 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 754252005283 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 754252005284 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 754252005285 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 754252005286 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 754252005287 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 754252005288 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 754252005289 active site 754252005290 Predicted methyltransferases [General function prediction only]; Region: COG0313 754252005291 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 754252005292 putative SAM binding site [chemical binding]; other site 754252005293 putative homodimer interface [polypeptide binding]; other site 754252005294 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 754252005295 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 754252005296 putative active site [active] 754252005297 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 754252005298 Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297 754252005299 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 754252005300 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 754252005301 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 754252005302 Ligand Binding Site [chemical binding]; other site 754252005303 CrcB-like protein; Region: CRCB; pfam02537 754252005304 CrcB-like protein; Region: CRCB; cl09114 754252005305 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 754252005306 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 754252005307 Coenzyme A binding pocket [chemical binding]; other site 754252005308 glutamate dehydrogenase; Provisional; Region: PRK09414 754252005309 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 754252005310 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 754252005311 NAD(P) binding site [chemical binding]; other site 754252005312 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754252005313 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754252005314 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 754252005315 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 754252005316 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754252005317 metabolite-proton symporter; Region: 2A0106; TIGR00883 754252005318 putative substrate translocation pore; other site 754252005319 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754252005320 Major Facilitator Superfamily; Region: MFS_1; pfam07690 754252005321 putative substrate translocation pore; other site 754252005322 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754252005323 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 754252005324 dimerization interface [polypeptide binding]; other site 754252005325 putative DNA binding site [nucleotide binding]; other site 754252005326 putative Zn2+ binding site [ion binding]; other site 754252005327 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 754252005328 MarR family; Region: MarR_2; pfam12802 754252005329 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 754252005330 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 754252005331 active site 754252005332 Peptidase family M23; Region: Peptidase_M23; pfam01551 754252005333 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 754252005334 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754252005335 active site 754252005336 phosphorylation site [posttranslational modification] 754252005337 intermolecular recognition site; other site 754252005338 dimerization interface [polypeptide binding]; other site 754252005339 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 754252005340 DNA binding residues [nucleotide binding] 754252005341 dimerization interface [polypeptide binding]; other site 754252005342 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 754252005343 Histidine kinase; Region: HisKA_3; pfam07730 754252005344 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 754252005345 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 754252005346 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 754252005347 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 754252005348 DNA binding residues [nucleotide binding] 754252005349 chaperone protein DnaJ; Provisional; Region: PRK14295 754252005350 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 754252005351 HSP70 interaction site [polypeptide binding]; other site 754252005352 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 754252005353 substrate binding site [polypeptide binding]; other site 754252005354 dimer interface [polypeptide binding]; other site 754252005355 GrpE; Region: GrpE; pfam01025 754252005356 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 754252005357 dimer interface [polypeptide binding]; other site 754252005358 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 754252005359 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 754252005360 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 754252005361 nucleotide binding site [chemical binding]; other site 754252005362 NEF interaction site [polypeptide binding]; other site 754252005363 SBD interface [polypeptide binding]; other site 754252005364 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 754252005365 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 754252005366 protein binding site [polypeptide binding]; other site 754252005367 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 754252005368 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754252005369 active site 754252005370 phosphorylation site [posttranslational modification] 754252005371 intermolecular recognition site; other site 754252005372 dimerization interface [polypeptide binding]; other site 754252005373 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 754252005374 DNA binding residues [nucleotide binding] 754252005375 dimerization interface [polypeptide binding]; other site 754252005376 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 754252005377 Histidine kinase; Region: HisKA_3; pfam07730 754252005378 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 754252005379 ATP binding site [chemical binding]; other site 754252005380 Mg2+ binding site [ion binding]; other site 754252005381 G-X-G motif; other site 754252005382 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 754252005383 Clp amino terminal domain; Region: Clp_N; pfam02861 754252005384 Clp amino terminal domain; Region: Clp_N; pfam02861 754252005385 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 754252005386 Walker A motif; other site 754252005387 ATP binding site [chemical binding]; other site 754252005388 Walker B motif; other site 754252005389 arginine finger; other site 754252005390 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 754252005391 Walker A motif; other site 754252005392 ATP binding site [chemical binding]; other site 754252005393 Walker B motif; other site 754252005394 arginine finger; other site 754252005395 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 754252005396 thioredoxin 2; Provisional; Region: PRK10996 754252005397 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 754252005398 catalytic residues [active] 754252005400 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 754252005401 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 754252005402 catalytic residues [active] 754252005403 Recombinase; Region: Recombinase; pfam07508 754252005404 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 754252005405 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 754252005406 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 754252005407 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 754252005408 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 754252005409 dimer interface [polypeptide binding]; other site 754252005410 putative functional site; other site 754252005411 putative MPT binding site; other site 754252005412 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 754252005413 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 754252005414 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 754252005415 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 754252005416 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 754252005417 Eukaryotic UGPase catalyses the synthesis of UDP-Glucose; Region: UGPase_euk; cd00897 754252005418 active site 754252005419 substrate binding site; other site 754252005420 Isochorismatase family; Region: Isochorismatase; pfam00857 754252005421 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 754252005422 catalytic triad [active] 754252005423 dimer interface [polypeptide binding]; other site 754252005424 conserved cis-peptide bond; other site 754252005425 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 754252005426 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 754252005427 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 754252005428 catalytic residues [active] 754252005429 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 754252005430 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 754252005431 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 754252005432 phosphoserine aminotransferase; Provisional; Region: PRK03080 754252005433 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 754252005434 catalytic residue [active] 754252005435 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 754252005436 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 754252005437 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 754252005438 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 754252005439 DNA-binding site [nucleotide binding]; DNA binding site 754252005440 RNA-binding motif; other site 754252005441 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 754252005442 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 754252005443 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 754252005444 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 754252005445 Transposase; Region: DDE_Tnp_ISL3; pfam01610 754252005446 Immunoglobulin I-set domain; Region: I-set; pfam07679 754252005447 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 754252005448 Transposase; Region: DDE_Tnp_ISL3; pfam01610 754252005449 Immunoglobulin I-set domain; Region: I-set; pfam07679 754252005450 Immunoglobulin like; Region: IG_like; smart00410 754252005451 S-layer homology domain; Region: SLH; pfam00395 754252005452 S-layer homology domain; Region: SLH; pfam00395 754252005453 S-layer homology domain; Region: SLH; pfam00395 754252005454 S-layer homology domain; Region: SLH; pfam00395 754252005455 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 754252005456 nudix motif; other site 754252005457 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 754252005458 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 754252005459 ring oligomerisation interface [polypeptide binding]; other site 754252005460 ATP/Mg binding site [chemical binding]; other site 754252005461 stacking interactions; other site 754252005462 hinge regions; other site 754252005463 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 754252005464 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 754252005465 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 754252005466 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 754252005467 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 754252005468 TrkA-N domain; Region: TrkA_N; pfam02254 754252005469 Flavivirus DEAD domain; Region: Flavi_DEAD; pfam07652 754252005470 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 754252005471 TrkA-N domain; Region: TrkA_N; pfam02254 754252005472 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 754252005473 putative ADP-ribose binding site [chemical binding]; other site 754252005474 putative active site [active] 754252005475 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 754252005476 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 754252005477 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 754252005478 metal binding site [ion binding]; metal-binding site 754252005479 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 754252005480 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 754252005481 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 754252005482 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 754252005483 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 754252005484 Walker A/P-loop; other site 754252005485 ATP binding site [chemical binding]; other site 754252005486 Q-loop/lid; other site 754252005487 ABC transporter signature motif; other site 754252005488 Walker B; other site 754252005489 D-loop; other site 754252005490 H-loop/switch region; other site 754252005491 O-succinylhomoserine (thiol)-lyase; Region: O_succ_thio_ly; TIGR02080 754252005492 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 754252005493 homodimer interface [polypeptide binding]; other site 754252005494 substrate-cofactor binding pocket; other site 754252005495 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754252005496 catalytic residue [active] 754252005497 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 754252005498 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 754252005499 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 754252005500 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 754252005501 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 754252005502 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 754252005503 Cysteine-rich domain; Region: CCG; pfam02754 754252005504 Cysteine-rich domain; Region: CCG; pfam02754 754252005505 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 754252005506 L-lactate permease; Region: Lactate_perm; cl00701 754252005507 Transcriptional regulators [Transcription]; Region: GntR; COG1802 754252005508 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 754252005509 DNA-binding site [nucleotide binding]; DNA binding site 754252005510 FCD domain; Region: FCD; pfam07729 754252005511 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 754252005512 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 754252005513 active site 754252005514 HIGH motif; other site 754252005515 nucleotide binding site [chemical binding]; other site 754252005516 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 754252005517 KMSKS motif; other site 754252005518 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 754252005519 tRNA binding surface [nucleotide binding]; other site 754252005520 anticodon binding site; other site 754252005521 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 754252005522 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 754252005523 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 754252005524 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 754252005525 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 754252005526 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 754252005527 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 754252005528 active site 754252005529 homodimer interface [polypeptide binding]; other site 754252005530 serine hydroxymethyltransferase; Provisional; Region: PRK13580 754252005531 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 754252005532 dimer interface [polypeptide binding]; other site 754252005533 active site 754252005534 glycine-pyridoxal phosphate binding site [chemical binding]; other site 754252005535 folate binding site [chemical binding]; other site 754252005536 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 754252005537 homotrimer interaction site [polypeptide binding]; other site 754252005538 zinc binding site [ion binding]; other site 754252005539 CDP-binding sites; other site 754252005540 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 754252005541 substrate binding site; other site 754252005542 dimer interface; other site 754252005543 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 754252005544 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 754252005545 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754252005546 active site 754252005547 phosphorylation site [posttranslational modification] 754252005548 intermolecular recognition site; other site 754252005549 dimerization interface [polypeptide binding]; other site 754252005550 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 754252005551 DNA binding site [nucleotide binding] 754252005552 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 754252005553 dimer interface [polypeptide binding]; other site 754252005554 phosphorylation site [posttranslational modification] 754252005555 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 754252005556 ATP binding site [chemical binding]; other site 754252005557 Mg2+ binding site [ion binding]; other site 754252005558 G-X-G motif; other site 754252005559 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 754252005560 PhoU domain; Region: PhoU; pfam01895 754252005561 PhoU domain; Region: PhoU; pfam01895 754252005562 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 754252005563 catalytic core [active] 754252005564 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 754252005565 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 754252005566 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 754252005567 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 754252005568 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 754252005569 NAD(P) binding site [chemical binding]; other site 754252005570 active site 754252005571 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 754252005572 carboxyltransferase (CT) interaction site; other site 754252005573 biotinylation site [posttranslational modification]; other site 754252005574 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 754252005575 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 754252005576 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 754252005577 oxaloacetate decarboxylase; Provisional; Region: PRK12330 754252005578 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 754252005579 active site 754252005580 catalytic residues [active] 754252005581 metal binding site [ion binding]; metal-binding site 754252005582 homodimer binding site [polypeptide binding]; other site 754252005583 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 754252005584 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 754252005585 inhibitor-cofactor binding pocket; inhibition site 754252005586 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754252005587 catalytic residue [active] 754252005588 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 754252005589 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 754252005590 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754252005591 putative substrate translocation pore; other site 754252005592 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754252005593 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 754252005594 dimer interface [polypeptide binding]; other site 754252005595 active site 754252005596 Schiff base residues; other site 754252005597 ferrochelatase; Reviewed; Region: hemH; PRK00035 754252005598 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 754252005599 C-terminal domain interface [polypeptide binding]; other site 754252005600 active site 754252005601 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 754252005602 active site 754252005603 N-terminal domain interface [polypeptide binding]; other site 754252005604 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 754252005605 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 754252005606 radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053 754252005607 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 754252005608 FeS/SAM binding site; other site 754252005609 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 754252005610 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 754252005611 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 754252005612 active site 754252005613 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 754252005614 substrate binding site [chemical binding]; other site 754252005615 active site 754252005616 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 754252005617 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 754252005618 domain interfaces; other site 754252005619 active site 754252005620 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 754252005621 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 754252005622 NAD(P) binding pocket [chemical binding]; other site 754252005623 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 754252005624 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 754252005625 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 754252005626 active site 754252005627 dimer interface [polypeptide binding]; other site 754252005628 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 754252005629 Ligand Binding Site [chemical binding]; other site 754252005630 Molecular Tunnel; other site 754252005631 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 754252005632 Lysine efflux permease [General function prediction only]; Region: COG1279 754252005633 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 754252005634 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 754252005635 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 754252005636 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 754252005637 Transaldolase; Region: Transaldolase; pfam00923 754252005638 catalytic residue [active] 754252005639 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 754252005640 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 754252005641 DNA-binding site [nucleotide binding]; DNA binding site 754252005642 UTRA domain; Region: UTRA; pfam07702 754252005643 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 754252005644 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 754252005645 substrate binding site [chemical binding]; other site 754252005646 ATP binding site [chemical binding]; other site 754252005647 KduI/IolB family; Region: KduI; pfam04962 754252005648 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 754252005649 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 754252005650 PYR/PP interface [polypeptide binding]; other site 754252005651 dimer interface [polypeptide binding]; other site 754252005652 TPP binding site [chemical binding]; other site 754252005653 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cd00368 754252005654 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 754252005655 TPP-binding site [chemical binding]; other site 754252005656 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 754252005657 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 754252005658 tetrameric interface [polypeptide binding]; other site 754252005659 NAD binding site [chemical binding]; other site 754252005660 catalytic residues [active] 754252005661 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 754252005662 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754252005663 putative substrate translocation pore; other site 754252005664 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754252005665 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 754252005666 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH10; cd08263 754252005667 putative NAD(P) binding site [chemical binding]; other site 754252005668 catalytic Zn binding site [ion binding]; other site 754252005669 structural Zn binding site [ion binding]; other site 754252005670 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 754252005671 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 754252005672 active site 754252005673 intersubunit interface [polypeptide binding]; other site 754252005674 zinc binding site [ion binding]; other site 754252005675 Na+ binding site [ion binding]; other site 754252005676 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 754252005677 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 754252005678 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 754252005679 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 754252005680 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 754252005681 active site 754252005682 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 754252005683 active site 754252005684 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754252005685 Predicted membrane protein [Function unknown]; Region: COG1297 754252005686 putative oligopeptide transporter, OPT family; Region: TIGR00733 754252005687 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 754252005688 Clp amino terminal domain; Region: Clp_N; pfam02861 754252005689 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 754252005690 Walker A motif; other site 754252005691 ATP binding site [chemical binding]; other site 754252005692 Walker B motif; other site 754252005693 arginine finger; other site 754252005694 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 754252005695 Walker A motif; other site 754252005696 ATP binding site [chemical binding]; other site 754252005697 Walker B motif; other site 754252005698 arginine finger; other site 754252005699 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 754252005700 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 754252005701 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 754252005702 inhibitor-cofactor binding pocket; inhibition site 754252005703 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754252005704 catalytic residue [active] 754252005705 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 754252005706 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 754252005707 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 754252005708 GDP-binding site [chemical binding]; other site 754252005709 ACT binding site; other site 754252005710 IMP binding site; other site 754252005711 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 754252005712 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 754252005713 NAD(P) binding site [chemical binding]; other site 754252005714 catalytic residues [active] 754252005715 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 754252005716 active site 754252005717 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 754252005718 DNA containing 6-O-methylguanine + protein L-cysteine <=> protein S-methyl-L-cysteine + DNA containing guanine 754252005719 DNA containing 6-O-methylguanine + protein L-cysteine <=> protein S-methyl-L-cysteine + DNA containing guanine 754252005720 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 754252005721 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 754252005722 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 754252005723 Multicopper oxidase; Region: Cu-oxidase; pfam00394 754252005724 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 754252005725 Transposase; Region: HTH_Tnp_1; cl17663 754252005726 putative transposase OrfB; Reviewed; Region: PHA02517 754252005727 HTH-like domain; Region: HTH_21; pfam13276 754252005728 Integrase core domain; Region: rve; pfam00665 754252005729 Integrase core domain; Region: rve_3; cl15866 754252005730 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 754252005731 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 754252005732 active site 754252005733 phosphodiesterase YaeI; Provisional; Region: PRK11340 754252005734 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 754252005735 active site 754252005736 metal binding site [ion binding]; metal-binding site 754252005737 Transglycosylase; Region: Transgly; pfam00912 754252005738 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 754252005739 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 754252005740 Transcription factor WhiB; Region: Whib; pfam02467 754252005741 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 754252005742 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 754252005743 homotrimer interaction site [polypeptide binding]; other site 754252005744 putative active site [active] 754252005745 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 754252005746 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 754252005747 minor groove reading motif; other site 754252005748 helix-hairpin-helix signature motif; other site 754252005749 substrate binding pocket [chemical binding]; other site 754252005750 active site 754252005751 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 754252005752 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 754252005753 putative active site [active] 754252005754 putative CoA binding site [chemical binding]; other site 754252005755 nudix motif; other site 754252005756 metal binding site [ion binding]; metal-binding site 754252005757 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 754252005758 RNA binding surface [nucleotide binding]; other site 754252005759 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 754252005760 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 754252005761 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 754252005762 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 754252005763 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 754252005764 dimerization domain swap beta strand [polypeptide binding]; other site 754252005765 regulatory protein interface [polypeptide binding]; other site 754252005766 active site 754252005767 regulatory phosphorylation site [posttranslational modification]; other site 754252005768 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 754252005769 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 754252005770 Soluble P-type ATPase [General function prediction only]; Region: COG4087 754252005771 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 754252005772 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 754252005773 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 754252005774 catalytic residues [active] 754252005775 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 754252005776 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 754252005777 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 754252005778 phosphopeptide binding site; other site 754252005779 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 754252005780 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 754252005781 phosphopeptide binding site; other site 754252005782 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 754252005783 active site 754252005784 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 754252005785 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 754252005786 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 754252005787 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 754252005788 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 754252005789 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 754252005790 active site 754252005791 ATP binding site [chemical binding]; other site 754252005792 substrate binding site [chemical binding]; other site 754252005793 activation loop (A-loop); other site 754252005794 PASTA domain; Region: PASTA; smart00740 754252005795 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 754252005796 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 754252005797 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 754252005798 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 754252005799 active site 754252005800 ATP binding site [chemical binding]; other site 754252005801 substrate binding site [chemical binding]; other site 754252005802 activation loop (A-loop); other site 754252005803 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 754252005804 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 754252005805 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 754252005806 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; cl07364 754252005807 NifU-like domain; Region: NifU; cl00484 754252005808 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 754252005809 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 754252005810 Switch I region; other site 754252005811 G2 box; other site 754252005812 G3 box; other site 754252005813 Switch II region; other site 754252005814 GTP/Mg2+ binding site [chemical binding]; other site 754252005815 G4 box; other site 754252005816 G5 box; other site 754252005817 Nucleoside recognition; Region: Gate; pfam07670 754252005818 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 754252005819 Nucleoside recognition; Region: Gate; pfam07670 754252005820 FeoA domain; Region: FeoA; pfam04023 754252005821 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 754252005822 potassium/proton antiporter; Reviewed; Region: PRK05326 754252005823 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 754252005824 TrkA-C domain; Region: TrkA_C; pfam02080 754252005825 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 754252005826 nucleoside/Zn binding site; other site 754252005827 dimer interface [polypeptide binding]; other site 754252005828 catalytic motif [active] 754252005829 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 754252005830 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 754252005831 active site 754252005832 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 754252005833 active site 754252005834 catalytic site [active] 754252005835 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 754252005836 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 754252005837 Transposase; Region: DDE_Tnp_ISL3; pfam01610 754252005840 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 754252005841 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 754252005842 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 754252005843 G1 box; other site 754252005844 putative GEF interaction site [polypeptide binding]; other site 754252005845 GTP/Mg2+ binding site [chemical binding]; other site 754252005846 Switch I region; other site 754252005847 G2 box; other site 754252005848 G3 box; other site 754252005849 Switch II region; other site 754252005850 G4 box; other site 754252005851 G5 box; other site 754252005852 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 754252005853 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 754252005854 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 754252005855 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 754252005856 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 754252005857 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 754252005858 heme-binding site [chemical binding]; other site 754252005859 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 754252005860 putative active site [active] 754252005861 dimerization interface [polypeptide binding]; other site 754252005862 putative tRNAtyr binding site [nucleotide binding]; other site 754252005863 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 754252005864 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 754252005865 DNA binding site [nucleotide binding] 754252005866 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 754252005867 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 754252005868 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 754252005869 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 754252005870 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 754252005871 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 754252005872 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 754252005873 NAD(P) binding site [chemical binding]; other site 754252005874 active site 754252005875 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 754252005876 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 754252005877 Coenzyme A binding pocket [chemical binding]; other site 754252005878 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 754252005879 Coenzyme A binding pocket [chemical binding]; other site 754252005880 polyphosphate kinase; Provisional; Region: PRK05443 754252005881 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 754252005882 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 754252005883 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 754252005884 putative domain interface [polypeptide binding]; other site 754252005885 putative active site [active] 754252005886 catalytic site [active] 754252005887 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 754252005888 putative domain interface [polypeptide binding]; other site 754252005889 putative active site [active] 754252005890 catalytic site [active] 754252005891 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 754252005892 active site 754252005893 Ap6A binding site [chemical binding]; other site 754252005894 nudix motif; other site 754252005895 metal binding site [ion binding]; metal-binding site 754252005896 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 754252005897 catalytic core [active] 754252005898 PBP superfamily domain; Region: PBP_like_2; cl17296 754252005899 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 754252005900 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754252005901 dimer interface [polypeptide binding]; other site 754252005902 conserved gate region; other site 754252005903 putative PBP binding loops; other site 754252005904 ABC-ATPase subunit interface; other site 754252005905 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 754252005906 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754252005907 dimer interface [polypeptide binding]; other site 754252005908 conserved gate region; other site 754252005909 putative PBP binding loops; other site 754252005910 ABC-ATPase subunit interface; other site 754252005911 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 754252005912 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 754252005913 Walker A/P-loop; other site 754252005914 ATP binding site [chemical binding]; other site 754252005915 Q-loop/lid; other site 754252005916 ABC transporter signature motif; other site 754252005917 Walker B; other site 754252005918 D-loop; other site 754252005919 H-loop/switch region; other site 754252005920 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 754252005921 Low molecular weight phosphatase family; Region: LMWPc; cd00115 754252005922 active site 754252005923 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 754252005924 dimerization interface [polypeptide binding]; other site 754252005925 putative DNA binding site [nucleotide binding]; other site 754252005926 putative Zn2+ binding site [ion binding]; other site 754252005927 Transcriptional regulators [Transcription]; Region: MarR; COG1846 754252005928 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 754252005929 arsenical pump-driving ATPase; Region: arsen_driv_ArsA; TIGR04291 754252005930 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 754252005931 P loop; other site 754252005932 Nucleotide binding site [chemical binding]; other site 754252005933 DTAP/Switch II; other site 754252005934 Switch I; other site 754252005935 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 754252005936 DTAP/Switch II; other site 754252005937 Switch I; other site 754252005938 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 754252005939 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 754252005940 mycothione reductase; Reviewed; Region: PRK07846 754252005941 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 754252005942 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 754252005943 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 754252005944 catalytic core [active] 754252005945 Putative carbohydrate binding domain; Region: CHB_HEX; cl03918 754252005946 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 754252005947 active site 754252005948 homodimer interface [polypeptide binding]; other site 754252005949 SAM binding site [chemical binding]; other site 754252005950 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 754252005951 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 754252005952 active site 754252005953 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 754252005954 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 754252005955 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 754252005956 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 754252005957 Protein of unknown function (DUF1211); Region: DUF1211; pfam06736 754252005958 CAAX protease self-immunity; Region: Abi; pfam02517 754252005959 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 754252005960 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 754252005961 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 754252005962 Metal-binding active site; metal-binding site 754252005963 AP (apurinic/apyrimidinic) site pocket; other site 754252005964 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 754252005965 DNA repair protein RadA; Provisional; Region: PRK11823 754252005966 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 754252005967 Walker A motif; other site 754252005968 ATP binding site [chemical binding]; other site 754252005969 Walker B motif; other site 754252005970 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 754252005971 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 754252005972 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 754252005973 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 754252005974 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 754252005975 minor groove reading motif; other site 754252005976 helix-hairpin-helix signature motif; other site 754252005977 substrate binding pocket [chemical binding]; other site 754252005978 active site 754252005979 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 754252005980 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 754252005981 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 754252005982 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 754252005983 Walker A/P-loop; other site 754252005984 ATP binding site [chemical binding]; other site 754252005985 Q-loop/lid; other site 754252005986 ABC transporter signature motif; other site 754252005987 Walker B; other site 754252005988 D-loop; other site 754252005989 H-loop/switch region; other site 754252005990 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 754252005991 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 754252005992 Q-loop/lid; other site 754252005993 ABC transporter signature motif; other site 754252005994 Walker B; other site 754252005995 D-loop; other site 754252005996 H-loop/switch region; other site 754252005997 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 754252005998 hypothetical protein; Provisional; Region: PRK06547 754252005999 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 754252006000 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 754252006001 active site 754252006002 catalytic residue [active] 754252006003 dimer interface [polypeptide binding]; other site 754252006004 Clp protease ATP binding subunit; Region: clpC; CHL00095 754252006005 Clp amino terminal domain; Region: Clp_N; pfam02861 754252006006 Clp amino terminal domain; Region: Clp_N; pfam02861 754252006007 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 754252006008 Walker A motif; other site 754252006009 ATP binding site [chemical binding]; other site 754252006010 Walker B motif; other site 754252006011 arginine finger; other site 754252006012 UvrB/uvrC motif; Region: UVR; pfam02151 754252006013 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 754252006014 Walker A motif; other site 754252006015 ATP binding site [chemical binding]; other site 754252006016 Walker B motif; other site 754252006017 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 754252006018 Lsr2; Region: Lsr2; pfam11774 754252006019 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 754252006020 catalytic center binding site [active] 754252006021 ATP binding site [chemical binding]; other site 754252006022 Dihydroneopterin aldolase; Region: FolB; smart00905 754252006023 active site 754252006024 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 754252006025 dihydropteroate synthase; Region: DHPS; TIGR01496 754252006026 substrate binding pocket [chemical binding]; other site 754252006027 dimer interface [polypeptide binding]; other site 754252006028 inhibitor binding site; inhibition site 754252006029 Predicted transcriptional regulators [Transcription]; Region: COG1725 754252006030 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 754252006031 DNA-binding site [nucleotide binding]; DNA binding site 754252006032 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 754252006033 homodecamer interface [polypeptide binding]; other site 754252006034 GTP cyclohydrolase I; Provisional; Region: PLN03044 754252006035 active site 754252006036 putative catalytic site residues [active] 754252006037 zinc binding site [ion binding]; other site 754252006038 GTP-CH-I/GFRP interaction surface; other site 754252006039 AAA domain; Region: AAA_30; pfam13604 754252006040 Family description; Region: UvrD_C_2; pfam13538 754252006041 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 754252006042 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 754252006043 active site 754252006044 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 754252006045 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 754252006046 Ligand Binding Site [chemical binding]; other site 754252006047 TilS substrate binding domain; Region: TilS; pfam09179 754252006048 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 754252006049 Uncharacterized conserved protein (DUF2342); Region: DUF2342; cl02183 754252006050 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 754252006051 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 754252006052 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 754252006053 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 754252006054 dimer interface [polypeptide binding]; other site 754252006055 substrate binding site [chemical binding]; other site 754252006056 metal binding sites [ion binding]; metal-binding site 754252006057 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 754252006058 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 754252006059 catalytic core [active] 754252006060 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 754252006061 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 754252006062 oligomer interface [polypeptide binding]; other site 754252006063 Cl binding site [ion binding]; other site 754252006064 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 754252006065 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 754252006066 Nitrogen regulatory protein P-II; Region: P-II; smart00938 754252006067 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 754252006068 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 754252006069 hydroxyglutarate oxidase; Provisional; Region: PRK11728 754252006070 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 754252006071 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 754252006072 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 754252006073 FtsX-like permease family; Region: FtsX; pfam02687 754252006074 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 754252006075 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 754252006076 Walker A/P-loop; other site 754252006077 ATP binding site [chemical binding]; other site 754252006078 Q-loop/lid; other site 754252006079 ABC transporter signature motif; other site 754252006080 Walker B; other site 754252006081 D-loop; other site 754252006082 H-loop/switch region; other site 754252006083 PSP1 C-terminal conserved region; Region: PSP1; cl00770 754252006084 DNA polymerase III subunit delta'; Validated; Region: PRK07940 754252006085 DNA polymerase III subunit delta'; Validated; Region: PRK08485 754252006086 thymidylate kinase; Validated; Region: tmk; PRK00698 754252006087 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 754252006088 TMP-binding site; other site 754252006089 ATP-binding site [chemical binding]; other site 754252006090 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 754252006091 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 754252006092 active site 754252006093 interdomain interaction site; other site 754252006094 putative metal-binding site [ion binding]; other site 754252006095 nucleotide binding site [chemical binding]; other site 754252006096 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 754252006097 domain I; other site 754252006098 phosphate binding site [ion binding]; other site 754252006099 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 754252006100 domain II; other site 754252006101 domain III; other site 754252006102 nucleotide binding site [chemical binding]; other site 754252006103 DNA binding groove [nucleotide binding] 754252006104 catalytic site [active] 754252006105 domain IV; other site 754252006106 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 754252006107 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 754252006108 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 754252006109 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754252006110 S-adenosylmethionine binding site [chemical binding]; other site 754252006111 DEAD/DEAH box helicase; Region: DEAD; pfam00270 754252006112 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 754252006113 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 754252006114 putative Mg++ binding site [ion binding]; other site 754252006115 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 754252006116 nucleotide binding region [chemical binding]; other site 754252006117 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 754252006118 DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519 754252006119 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 754252006120 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 754252006121 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 754252006122 putative [Fe4-S4] binding site [ion binding]; other site 754252006123 putative molybdopterin cofactor binding site [chemical binding]; other site 754252006124 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 754252006125 molybdopterin cofactor binding site; other site 754252006126 hypothetical protein; Provisional; Region: PRK13795 754252006127 Nitrate reductase delta subunit; Region: Nitrate_red_del; pfam02613 754252006128 helicase/secretion neighborhood TadE-like protein; Region: tadE_like_DECH; TIGR03816 754252006129 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 754252006130 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 754252006131 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 754252006132 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 754252006133 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 754252006134 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 754252006135 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 754252006136 ATP binding site [chemical binding]; other site 754252006137 Walker A motif; other site 754252006138 hexamer interface [polypeptide binding]; other site 754252006139 Walker B motif; other site 754252006140 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 754252006141 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754252006142 S-adenosylmethionine binding site [chemical binding]; other site 754252006143 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 754252006144 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 754252006145 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 754252006146 metal-binding site [ion binding] 754252006147 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 754252006148 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 754252006149 metal-binding site [ion binding] 754252006150 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 754252006151 putative homodimer interface [polypeptide binding]; other site 754252006152 putative homotetramer interface [polypeptide binding]; other site 754252006153 putative allosteric switch controlling residues; other site 754252006154 putative metal binding site [ion binding]; other site 754252006155 putative homodimer-homodimer interface [polypeptide binding]; other site 754252006156 replicative DNA helicase; Region: DnaB; TIGR00665 754252006157 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 754252006158 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 754252006159 Walker A motif; other site 754252006160 ATP binding site [chemical binding]; other site 754252006161 Walker B motif; other site 754252006162 DNA binding loops [nucleotide binding] 754252006163 MarR family; Region: MarR_2; pfam12802 754252006164 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754252006165 putative substrate translocation pore; other site 754252006166 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 754252006167 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 754252006168 active site 754252006169 FMN binding site [chemical binding]; other site 754252006170 substrate binding site [chemical binding]; other site 754252006171 homotetramer interface [polypeptide binding]; other site 754252006172 catalytic residue [active] 754252006173 hypothetical protein; Provisional; Region: PRK08317 754252006174 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754252006175 S-adenosylmethionine binding site [chemical binding]; other site 754252006176 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 754252006177 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 754252006178 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 754252006179 ThiC-associated domain; Region: ThiC-associated; pfam13667 754252006180 ThiC family; Region: ThiC; pfam01964 754252006181 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u2; cd11478 754252006182 Na binding site [ion binding]; other site 754252006183 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 754252006184 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 754252006185 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 754252006186 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 754252006187 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 754252006188 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 754252006189 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 754252006190 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 754252006191 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 754252006192 manganese transport protein MntH; Reviewed; Region: PRK00701 754252006193 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 754252006194 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 754252006195 binding surface 754252006196 TPR motif; other site 754252006197 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 754252006198 metal ion-dependent adhesion site (MIDAS); other site 754252006199 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 754252006200 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 754252006201 Transposase; Region: DDE_Tnp_ISL3; pfam01610 754252006202 Abi-like protein; Region: Abi_2; pfam07751 754252006204 putative transposase OrfB; Reviewed; Region: PHA02517 754252006205 HTH-like domain; Region: HTH_21; pfam13276 754252006206 Integrase core domain; Region: rve; pfam00665 754252006207 Integrase core domain; Region: rve_3; cl15866 754252006208 Transposase; Region: HTH_Tnp_1; cl17663 754252006209 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 754252006210 Transposase; Region: DDE_Tnp_ISL3; pfam01610 754252006211 Homeodomain-like domain; Region: HTH_23; cl17451 754252006212 Winged helix-turn helix; Region: HTH_29; pfam13551 754252006213 Integrase core domain; Region: rve; pfam00665 754252006214 Integrase core domain; Region: rve_3; pfam13683 754252006215 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 754252006216 Coenzyme A binding pocket [chemical binding]; other site 754252006217 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 754252006218 dimer interface [polypeptide binding]; other site 754252006219 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 754252006220 ligand binding site [chemical binding]; other site 754252006221 Integrase core domain; Region: rve; pfam00665 754252006222 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 754252006223 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 754252006224 ATP binding site [chemical binding]; other site 754252006225 putative Mg++ binding site [ion binding]; other site 754252006226 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 754252006227 Tyrosine kinase, catalytic domain; Region: TyrKc; smart00219 754252006228 Catalytic domain of Protein Kinases; Region: PKc; cd00180 754252006229 active site 754252006230 ATP binding site [chemical binding]; other site 754252006231 substrate binding site [chemical binding]; other site 754252006232 activation loop (A-loop); other site 754252006233 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 754252006234 active site 754252006235 DNA binding site [nucleotide binding] 754252006236 Int/Topo IB signature motif; other site 754252006237 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 754252006238 Catalytic site [active] 754252006239 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 754252006240 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 754252006241 active site 754252006242 DNA binding site [nucleotide binding] 754252006243 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 754252006244 Predicted DNA-binding protein with an HTH domain [General function prediction only]; Region: COG4710 754252006245 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 754252006246 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 754252006247 active site 754252006248 metal binding site [ion binding]; metal-binding site 754252006249 interdomain interaction site; other site 754252006250 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 754252006251 Helix-turn-helix domain; Region: HTH_38; pfam13936 754252006252 Integrase core domain; Region: rve; pfam00665 754252006253 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 754252006254 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 754252006255 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 754252006256 putative transposase OrfB; Reviewed; Region: PHA02517 754252006257 HTH-like domain; Region: HTH_21; pfam13276 754252006258 Integrase core domain; Region: rve; pfam00665 754252006259 Integrase core domain; Region: rve_3; pfam13683 754252006260 Transposase; Region: HTH_Tnp_1; cl17663 754252006261 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 754252006262 Abi-like protein; Region: Abi_2; pfam07751 754252006264 Domain of unknown function (DUF3841); Region: DUF3841; pfam12952 754252006265 HsdM N-terminal domain; Region: HsdM_N; pfam12161 754252006266 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 754252006267 DNA methylase; Region: N6_N4_Mtase; pfam01555 754252006268 DNA methylase; Region: N6_N4_Mtase; pfam01555 754252006269 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 754252006270 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 754252006271 Domain of unknown function (DUF3841); Region: DUF3841; pfam12952 754252006272 Protein of unknown function (DUF4236); Region: DUF4236; pfam14020 754252006273 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 754252006274 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 754252006275 transmembrane helices; other site 754252006276 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 754252006277 homopentamer interface [polypeptide binding]; other site 754252006278 active site 754252006279 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 754252006280 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 754252006281 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 754252006282 dimerization interface [polypeptide binding]; other site 754252006283 active site 754252006284 riboflavin synthase; Region: PLN02741 754252006285 Lumazine binding domain; Region: Lum_binding; pfam00677 754252006286 Lumazine binding domain; Region: Lum_binding; pfam00677 754252006287 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 754252006288 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 754252006289 catalytic motif [active] 754252006290 Zn binding site [ion binding]; other site 754252006291 RibD C-terminal domain; Region: RibD_C; pfam01872 754252006292 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 754252006293 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 754252006294 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 754252006295 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 754252006296 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 754252006297 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 754252006298 ligand binding site [chemical binding]; other site 754252006299 homodimer interface [polypeptide binding]; other site 754252006300 NAD(P) binding site [chemical binding]; other site 754252006301 trimer interface B [polypeptide binding]; other site 754252006302 trimer interface A [polypeptide binding]; other site 754252006303 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 754252006304 Transcriptional regulators [Transcription]; Region: MarR; COG1846 754252006305 MarR family; Region: MarR_2; cl17246 754252006306 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754252006307 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 754252006308 Walker A/P-loop; other site 754252006309 ATP binding site [chemical binding]; other site 754252006310 Q-loop/lid; other site 754252006311 ABC transporter signature motif; other site 754252006312 Walker B; other site 754252006313 D-loop; other site 754252006314 H-loop/switch region; other site 754252006315 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 754252006316 ABC-2 type transporter; Region: ABC2_membrane; cl17235 754252006317 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 754252006318 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754252006319 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 754252006320 Walker A/P-loop; other site 754252006321 ATP binding site [chemical binding]; other site 754252006322 Q-loop/lid; other site 754252006323 ABC transporter signature motif; other site 754252006324 Walker B; other site 754252006325 D-loop; other site 754252006326 H-loop/switch region; other site 754252006327 sulfate transport protein; Provisional; Region: cysT; CHL00187 754252006328 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754252006329 dimer interface [polypeptide binding]; other site 754252006330 conserved gate region; other site 754252006331 putative PBP binding loops; other site 754252006332 ABC-ATPase subunit interface; other site 754252006333 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 754252006334 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754252006335 dimer interface [polypeptide binding]; other site 754252006336 conserved gate region; other site 754252006337 putative PBP binding loops; other site 754252006338 ABC-ATPase subunit interface; other site 754252006339 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 754252006340 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 754252006341 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 754252006342 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 754252006343 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 754252006344 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 754252006345 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 754252006346 Active Sites [active] 754252006347 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 754252006348 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 754252006349 Active Sites [active] 754252006350 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 754252006351 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 754252006352 G1 box; other site 754252006353 putative GEF interaction site [polypeptide binding]; other site 754252006354 GTP/Mg2+ binding site [chemical binding]; other site 754252006355 Switch I region; other site 754252006356 G2 box; other site 754252006357 CysD dimerization site [polypeptide binding]; other site 754252006358 G3 box; other site 754252006359 Switch II region; other site 754252006360 G4 box; other site 754252006361 G5 box; other site 754252006362 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 754252006363 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 754252006364 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 754252006365 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754252006366 S-adenosylmethionine binding site [chemical binding]; other site 754252006367 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 754252006368 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 754252006369 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 754252006370 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 754252006371 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 754252006372 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 754252006373 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 754252006374 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 754252006376 # Nitrite + Acceptor <=> Nitrate + Reduced acceptor # Ferricytochrome c + Nitrite <=> Nitrate + Ferrocytochrome c Ubiquinol + Nitrate <=> Ubiquinone + Nitrite 754252006377 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 754252006379 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 754252006380 MoaE homodimer interface [polypeptide binding]; other site 754252006381 MoaD interaction [polypeptide binding]; other site 754252006382 active site residues [active] 754252006383 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 754252006384 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 754252006385 ATP binding site [chemical binding]; other site 754252006386 substrate interface [chemical binding]; other site 754252006387 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 754252006388 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 754252006389 dimer interface [polypeptide binding]; other site 754252006390 putative functional site; other site 754252006391 putative MPT binding site; other site 754252006392 MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor...; Region: MoaC; cl00242 754252006393 trimer interface [polypeptide binding]; other site 754252006394 dimer interface [polypeptide binding]; other site 754252006395 putative active site [active] 754252006396 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 754252006397 MPT binding site; other site 754252006398 trimer interface [polypeptide binding]; other site 754252006399 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 754252006400 nucleotide binding site/active site [active] 754252006401 HIT family signature motif; other site 754252006402 catalytic residue [active] 754252006403 hypothetical protein; Provisional; Region: PRK07475 754252006404 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 754252006405 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 754252006406 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 754252006407 homotrimer interaction site [polypeptide binding]; other site 754252006408 putative active site [active] 754252006409 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 754252006410 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 754252006411 Walker A/P-loop; other site 754252006412 ATP binding site [chemical binding]; other site 754252006413 Q-loop/lid; other site 754252006414 ABC transporter signature motif; other site 754252006415 Walker B; other site 754252006416 D-loop; other site 754252006417 H-loop/switch region; other site 754252006418 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 754252006419 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 754252006420 substrate binding pocket [chemical binding]; other site 754252006421 membrane-bound complex binding site; other site 754252006422 hinge residues; other site 754252006423 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 754252006424 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754252006425 dimer interface [polypeptide binding]; other site 754252006426 conserved gate region; other site 754252006427 putative PBP binding loops; other site 754252006428 ABC-ATPase subunit interface; other site 754252006429 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 754252006430 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754252006431 dimer interface [polypeptide binding]; other site 754252006432 conserved gate region; other site 754252006433 putative PBP binding loops; other site 754252006434 ABC-ATPase subunit interface; other site 754252006435 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 754252006436 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 754252006437 NAD(P) binding site [chemical binding]; other site 754252006438 C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor; Region: CtBP_dh; cd05299 754252006439 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 754252006440 ligand binding site [chemical binding]; other site 754252006441 NAD binding site [chemical binding]; other site 754252006442 catalytic site [active] 754252006443 4-aminobutyrate aminotransferase; Provisional; Region: PRK08117 754252006444 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 754252006445 inhibitor-cofactor binding pocket; inhibition site 754252006446 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754252006447 catalytic residue [active] 754252006448 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 754252006449 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 754252006450 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 754252006451 Histidine kinase; Region: HisKA_3; pfam07730 754252006452 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 754252006453 ATP binding site [chemical binding]; other site 754252006454 Mg2+ binding site [ion binding]; other site 754252006455 G-X-G motif; other site 754252006456 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 754252006457 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754252006458 active site 754252006459 phosphorylation site [posttranslational modification] 754252006460 intermolecular recognition site; other site 754252006461 dimerization interface [polypeptide binding]; other site 754252006462 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 754252006463 DNA binding residues [nucleotide binding] 754252006464 dimerization interface [polypeptide binding]; other site 754252006465 Homeodomain-like domain; Region: HTH_23; cl17451 754252006466 Winged helix-turn helix; Region: HTH_29; pfam13551 754252006467 Integrase core domain; Region: rve; pfam00665 754252006468 Integrase core domain; Region: rve_3; pfam13683 754252006469 H+ Antiporter protein; Region: 2A0121; TIGR00900 754252006470 MarC family integral membrane protein; Region: MarC; cl00919 754252006471 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 754252006472 Bacterial transcriptional activator domain; Region: BTAD; smart01043 754252006473 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 754252006474 Walker A motif; other site 754252006475 ATP binding site [chemical binding]; other site 754252006476 Walker B motif; other site 754252006477 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 754252006478 UPF0126 domain; Region: UPF0126; pfam03458 754252006479 Predicted membrane protein [Function unknown]; Region: COG2860 754252006480 UPF0126 domain; Region: UPF0126; pfam03458 754252006481 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 754252006482 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 754252006483 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 754252006484 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 754252006485 intersubunit interface [polypeptide binding]; other site 754252006486 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 754252006487 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 754252006488 Soluble P-type ATPase [General function prediction only]; Region: COG4087 754252006489 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 754252006490 dimerization interface [polypeptide binding]; other site 754252006491 putative DNA binding site [nucleotide binding]; other site 754252006492 putative Zn2+ binding site [ion binding]; other site 754252006493 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 754252006494 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 754252006495 Coenzyme A binding pocket [chemical binding]; other site 754252006496 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 754252006497 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 754252006498 DNA binding residues [nucleotide binding] 754252006499 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754252006500 Major Facilitator Superfamily; Region: MFS_1; pfam07690 754252006501 putative substrate translocation pore; other site 754252006502 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 754252006503 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 754252006504 catalytic triad [active] 754252006505 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 754252006506 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 754252006507 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 754252006508 active site 754252006509 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 754252006510 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 754252006511 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 754252006512 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 754252006513 putative ADP-binding pocket [chemical binding]; other site 754252006514 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 754252006515 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 754252006516 active site 754252006517 phosphate binding residues; other site 754252006518 catalytic residues [active] 754252006519 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754252006520 Walker A/P-loop; other site 754252006521 ATP binding site [chemical binding]; other site 754252006522 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 754252006523 Q-loop/lid; other site 754252006524 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754252006525 ABC transporter signature motif; other site 754252006526 Walker B; other site 754252006527 D-loop; other site 754252006528 H-loop/switch region; other site 754252006529 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754252006530 Walker A/P-loop; other site 754252006531 ATP binding site [chemical binding]; other site 754252006532 Q-loop/lid; other site 754252006533 ABC transporter signature motif; other site 754252006534 Walker B; other site 754252006535 D-loop; other site 754252006536 H-loop/switch region; other site 754252006537 Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357 754252006538 CHY zinc finger; Region: zf-CHY; pfam05495 754252006539 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 754252006540 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 754252006541 TPP-binding site [chemical binding]; other site 754252006542 dimer interface [polypeptide binding]; other site 754252006543 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 754252006544 PYR/PP interface [polypeptide binding]; other site 754252006545 dimer interface [polypeptide binding]; other site 754252006546 TPP binding site [chemical binding]; other site 754252006547 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 754252006548 ribulokinase; Provisional; Region: PRK04123 754252006549 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 754252006550 N- and C-terminal domain interface [polypeptide binding]; other site 754252006551 active site 754252006552 MgATP binding site [chemical binding]; other site 754252006553 catalytic site [active] 754252006554 metal binding site [ion binding]; metal-binding site 754252006555 carbohydrate binding site [chemical binding]; other site 754252006556 homodimer interface [polypeptide binding]; other site 754252006557 Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175 754252006558 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 754252006559 active site 754252006560 metal binding site [ion binding]; metal-binding site 754252006561 Carbohydrate kinase and ribulose-phosphate 3-epimerase fusion proteins-like; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CarbK-RPE_like; cd07783 754252006562 Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069 754252006563 N- and C-terminal domain interface [polypeptide binding]; other site 754252006564 active site 754252006565 MgATP binding site [chemical binding]; other site 754252006566 catalytic site [active] 754252006567 metal binding site [ion binding]; metal-binding site 754252006568 putative carbohydrate binding site [chemical binding]; other site 754252006569 putative homodimer interface [polypeptide binding]; other site 754252006570 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 754252006571 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 754252006572 active site 754252006573 motif I; other site 754252006574 motif II; other site 754252006575 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 754252006576 motif II; other site 754252006577 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 754252006578 short chain dehydrogenase; Provisional; Region: PRK08219 754252006579 classical (c) SDRs; Region: SDR_c; cd05233 754252006580 NAD(P) binding site [chemical binding]; other site 754252006581 active site 754252006582 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 754252006583 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 754252006584 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 754252006585 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 754252006586 triosephosphate isomerase; Provisional; Region: PRK14567 754252006587 substrate binding site [chemical binding]; other site 754252006588 dimer interface [polypeptide binding]; other site 754252006589 catalytic triad [active] 754252006590 dihydroxyacetone kinase; Provisional; Region: PRK14479 754252006591 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 754252006592 DAK2 domain; Region: Dak2; pfam02734 754252006593 Transcriptional regulators [Transcription]; Region: GntR; COG1802 754252006594 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 754252006595 DNA-binding site [nucleotide binding]; DNA binding site 754252006596 FCD domain; Region: FCD; pfam07729 754252006597 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754252006598 D-galactonate transporter; Region: 2A0114; TIGR00893 754252006599 putative substrate translocation pore; other site 754252006600 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 754252006601 Amidohydrolase; Region: Amidohydro_2; pfam04909 754252006602 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 754252006603 Transposase; Region: DDE_Tnp_ISL3; pfam01610 754252006604 near tnpA 754252006606 signal peptide ? 754252006607 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 754252006608 Helix-turn-helix domain; Region: HTH_38; pfam13936 754252006609 Homeodomain-like domain; Region: HTH_32; pfam13565 754252006610 Integrase core domain; Region: rve; pfam00665 754252006611 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 754252006612 DNA-binding interface [nucleotide binding]; DNA binding site 754252006615 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 754252006616 active site 754252006617 DNA binding site [nucleotide binding] 754252006618 Int/Topo IB signature motif; other site 754252006620 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 754252006621 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 754252006622 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 754252006623 active site 754252006624 DNA binding site [nucleotide binding] 754252006625 Int/Topo IB signature motif; other site 754252006626 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 754252006627 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 754252006628 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 754252006629 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 754252006630 active site 754252006631 catalytic site [active] 754252006632 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 754252006633 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 754252006634 sequence-specific DNA binding site [nucleotide binding]; other site 754252006635 salt bridge; other site 754252006636 putative transposase OrfB; Reviewed; Region: PHA02517 754252006637 HTH-like domain; Region: HTH_21; pfam13276 754252006638 Integrase core domain; Region: rve; pfam00665 754252006639 Integrase core domain; Region: rve_3; pfam13683 754252006640 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 754252006641 DNA-binding interface [nucleotide binding]; DNA binding site 754252006642 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 754252006643 Transposase; Region: DDE_Tnp_ISL3; pfam01610 754252006644 Homeodomain-like domain; Region: HTH_23; cl17451 754252006645 Winged helix-turn helix; Region: HTH_29; pfam13551 754252006646 Integrase core domain; Region: rve; pfam00665 754252006647 Integrase core domain; Region: rve_3; pfam13683 754252006648 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 754252006649 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 754252006650 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 754252006651 catalytic residues [active] 754252006652 catalytic nucleophile [active] 754252006653 Presynaptic Site I dimer interface [polypeptide binding]; other site 754252006654 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 754252006655 Synaptic Flat tetramer interface [polypeptide binding]; other site 754252006656 Synaptic Site I dimer interface [polypeptide binding]; other site 754252006657 DNA binding site [nucleotide binding] 754252006658 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 754252006659 DNA-binding interface [nucleotide binding]; DNA binding site 754252006660 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 754252006661 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 754252006662 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 754252006663 putative dimer interface [polypeptide binding]; other site 754252006664 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 754252006665 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 754252006666 putative dimer interface [polypeptide binding]; other site 754252006667 K+ potassium transporter; Region: K_trans; pfam02705 754252006668 potassium uptake protein; Region: kup; TIGR00794 754252006669 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 754252006670 Transposase; Region: DDE_Tnp_ISL3; pfam01610 754252006671 Predicted metal-dependent hydrolase of the TIM-barrel fold 754252006672 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754252006673 D-galactonate transporter; Region: 2A0114; TIGR00893 754252006674 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754252006675 Xylose isomerase [Carbohydrate transport and metabolism]; Region: XylA; cl09945 754252006676 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 754252006677 GntP family permease; Region: GntP_permease; pfam02447 754252006678 fructuronate transporter; Provisional; Region: PRK10034; cl15264 754252006679 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 754252006680 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 754252006681 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 754252006682 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 754252006683 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 754252006684 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754252006685 homodimer interface [polypeptide binding]; other site 754252006686 catalytic residue [active] 754252006687 NAD synthetase; Reviewed; Region: nadE; PRK02628 754252006688 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 754252006689 multimer interface [polypeptide binding]; other site 754252006690 active site 754252006691 catalytic triad [active] 754252006692 protein interface 1 [polypeptide binding]; other site 754252006693 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 754252006694 homodimer interface [polypeptide binding]; other site 754252006695 NAD binding pocket [chemical binding]; other site 754252006696 ATP binding pocket [chemical binding]; other site 754252006697 Mg binding site [ion binding]; other site 754252006698 active-site loop [active] 754252006699 Predicted transcriptional regulators [Transcription]; Region: COG1695 754252006700 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 754252006701 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 754252006702 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 754252006703 Walker A/P-loop; other site 754252006704 ATP binding site [chemical binding]; other site 754252006705 Q-loop/lid; other site 754252006706 ABC transporter signature motif; other site 754252006707 Walker B; other site 754252006708 D-loop; other site 754252006709 H-loop/switch region; other site 754252006710 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754252006711 dimer interface [polypeptide binding]; other site 754252006712 ABC-ATPase subunit interface; other site 754252006713 putative PBP binding loops; other site 754252006714 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 754252006715 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 754252006716 substrate binding pocket [chemical binding]; other site 754252006717 membrane-bound complex binding site; other site 754252006718 hinge residues; other site 754252006719 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 754252006720 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 754252006721 substrate binding pocket [chemical binding]; other site 754252006722 membrane-bound complex binding site; other site 754252006723 hinge residues; other site 754252006724 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 754252006725 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 754252006726 substrate binding pocket [chemical binding]; other site 754252006727 membrane-bound complex binding site; other site 754252006728 hinge residues; other site 754252006729 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 754252006730 Isochorismatase family; Region: Isochorismatase; pfam00857 754252006731 catalytic triad [active] 754252006732 conserved cis-peptide bond; other site 754252006733 Transcriptional regulators [Transcription]; Region: PurR; COG1609 754252006734 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 754252006735 DNA binding site [nucleotide binding] 754252006736 domain linker motif; other site 754252006737 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 754252006738 ligand binding site [chemical binding]; other site 754252006739 dimerization interface [polypeptide binding]; other site 754252006740 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 754252006741 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 754252006742 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754252006743 putative substrate translocation pore; other site 754252006744 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754252006745 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 754252006746 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 754252006747 acyl-activating enzyme (AAE) consensus motif; other site 754252006748 putative AMP binding site [chemical binding]; other site 754252006749 putative active site [active] 754252006750 putative CoA binding site [chemical binding]; other site 754252006751 endonuclease IV; Provisional; Region: PRK01060 754252006752 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 754252006753 AP (apurinic/apyrimidinic) site pocket; other site 754252006754 DNA interaction; other site 754252006755 Metal-binding active site; metal-binding site 754252006756 S-layer homology domain; Region: SLH; pfam00395 754252006757 S-layer homology domain; Region: SLH; pfam00395 754252006758 putative transposase OrfB; Reviewed; Region: PHA02517 754252006759 HTH-like domain; Region: HTH_21; pfam13276 754252006760 Integrase core domain; Region: rve; pfam00665 754252006761 Integrase core domain; Region: rve_3; pfam13683 754252006762 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 754252006763 DNA-binding interface [nucleotide binding]; DNA binding site 754252006764 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 754252006765 multiple promoter invertase; Provisional; Region: mpi; PRK13413 754252006766 catalytic residues [active] 754252006767 catalytic nucleophile [active] 754252006768 Presynaptic Site I dimer interface [polypeptide binding]; other site 754252006769 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 754252006770 Synaptic Flat tetramer interface [polypeptide binding]; other site 754252006771 Synaptic Site I dimer interface [polypeptide binding]; other site 754252006772 DNA binding site [nucleotide binding] 754252006773 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 754252006774 DNA-binding interface [nucleotide binding]; DNA binding site 754252006775 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 754252006776 Transposase; Region: DDE_Tnp_ISL3; pfam01610 754252006777 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 754252006778 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 754252006779 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 754252006780 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 754252006781 putative active site [active] 754252006782 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 754252006783 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 754252006784 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 754252006785 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 754252006786 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 754252006787 NAD(P) binding site [chemical binding]; other site 754252006788 active site 754252006789 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 754252006790 Transposase; Region: DDE_Tnp_ISL3; pfam01610 754252006792 inositol + NAD+ <=> 2,4,6/3,5-Pentahydroxycyclohexanone + NADH + H+ 754252006793 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 754252006794 Transcriptional regulators [Transcription]; Region: PurR; COG1609 754252006795 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 754252006796 DNA binding site [nucleotide binding] 754252006797 domain linker motif; other site 754252006798 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 754252006799 ligand binding site [chemical binding]; other site 754252006800 dimerization interface [polypeptide binding]; other site 754252006801 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 754252006802 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 754252006803 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 754252006804 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 754252006805 putative active site [active] 754252006806 catalytic site [active] 754252006807 putative metal binding site [ion binding]; other site 754252006808 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754252006809 Major Facilitator Superfamily; Region: MFS_1; pfam07690 754252006810 putative substrate translocation pore; other site 754252006811 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 754252006812 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 754252006813 FAD binding pocket [chemical binding]; other site 754252006814 conserved FAD binding motif [chemical binding]; other site 754252006815 phosphate binding motif [ion binding]; other site 754252006816 beta-alpha-beta structure motif; other site 754252006817 NAD binding pocket [chemical binding]; other site 754252006818 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 754252006819 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 754252006820 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 754252006821 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 754252006822 Transcriptional regulators [Transcription]; Region: PurR; COG1609 754252006823 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 754252006824 DNA binding site [nucleotide binding] 754252006825 domain linker motif; other site 754252006826 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 754252006827 dimerization interface [polypeptide binding]; other site 754252006828 ligand binding site [chemical binding]; other site 754252006829 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 754252006830 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 754252006831 active site residue [active] 754252006832 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 754252006833 active site residue [active] 754252006834 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 754252006835 tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812 754252006836 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754252006837 catalytic residue [active] 754252006838 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 754252006839 H+ Antiporter protein; Region: 2A0121; TIGR00900 754252006840 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754252006841 putative substrate translocation pore; other site 754252006842 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 754252006843 protochlorophyllide reductase; Region: PLN00015 754252006844 NAD(P) binding site [chemical binding]; other site 754252006845 active site 754252006846 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 754252006847 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754252006848 Walker A/P-loop; other site 754252006849 ATP binding site [chemical binding]; other site 754252006850 Q-loop/lid; other site 754252006851 ABC transporter signature motif; other site 754252006852 Walker B; other site 754252006853 D-loop; other site 754252006854 H-loop/switch region; other site 754252006855 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 754252006856 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754252006857 dimer interface [polypeptide binding]; other site 754252006858 conserved gate region; other site 754252006859 ABC-ATPase subunit interface; other site 754252006860 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 754252006861 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 754252006862 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754252006863 homodimer interface [polypeptide binding]; other site 754252006864 catalytic residue [active] 754252006865 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 754252006867 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754252006868 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754252006869 dimer interface [polypeptide binding]; other site 754252006870 conserved gate region; other site 754252006871 ABC-ATPase subunit interface; other site 754252006872 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 754252006873 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754252006874 dimer interface [polypeptide binding]; other site 754252006875 conserved gate region; other site 754252006876 putative PBP binding loops; other site 754252006877 ABC-ATPase subunit interface; other site 754252006878 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 754252006879 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 754252006880 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754252006881 Major Facilitator Superfamily; Region: MFS_1; pfam07690 754252006882 putative substrate translocation pore; other site 754252006883 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754252006884 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 754252006885 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 754252006886 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 754252006887 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 754252006888 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 754252006889 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 754252006890 dimer interface [polypeptide binding]; other site 754252006891 ssDNA binding site [nucleotide binding]; other site 754252006892 tetramer (dimer of dimers) interface [polypeptide binding]; other site 754252006893 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 754252006894 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cl00217 754252006895 Chlorite dismutase; Region: Chlor_dismutase; pfam06778 754252006896 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 754252006897 active site residue [active] 754252006898 Isochorismatase family; Region: Isochorismatase; pfam00857 754252006899 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 754252006900 catalytic triad [active] 754252006901 conserved cis-peptide bond; other site 754252006903 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 754252006904 Transposase; Region: DDE_Tnp_ISL3; pfam01610 754252006907 Major Facilitator Superfamily; Region: MFS_1; pfam07690 754252006908 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754252006909 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 754252006910 hypothetical protein; Reviewed; Region: PRK09588 754252006911 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 754252006912 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like; cd11354 754252006913 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 754252006914 active site 754252006915 catalytic site [active] 754252006916 Mannosyltransferase (PIG-V)); Region: Mannosyl_trans2; pfam04188 754252006917 Predicted integral membrane protein [Function unknown]; Region: COG5650 754252006918 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 754252006919 Transglycosylase; Region: Transgly; pfam00912 754252006920 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 754252006921 Domain of unknown function (DUF4209); Region: DUF4209; pfam13910 754252006922 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 754252006923 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 754252006924 Cytochrome P450; Region: p450; cl12078 754252006925 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 754252006926 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 754252006927 active site 754252006928 catalytic tetrad [active] 754252006929 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14950 754252006930 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 754252006931 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 754252006932 active site 754252006933 catalytic site [active] 754252006934 xanthine permease; Region: pbuX; TIGR03173 754252006935 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 754252006936 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 754252006937 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 754252006938 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 754252006939 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 754252006940 acyl-activating enzyme (AAE) consensus motif; other site 754252006941 AMP binding site [chemical binding]; other site 754252006942 active site 754252006943 CoA binding site [chemical binding]; other site 754252006944 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 754252006945 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 754252006946 heme binding pocket [chemical binding]; other site 754252006947 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 754252006948 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 754252006949 ABC1 family; Region: ABC1; pfam03109 754252006950 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 754252006951 active site 754252006952 ATP binding site [chemical binding]; other site 754252006953 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 754252006954 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 754252006955 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 754252006956 Cl- selectivity filter; other site 754252006957 Cl- binding residues [ion binding]; other site 754252006958 pore gating glutamate residue; other site 754252006959 dimer interface [polypeptide binding]; other site 754252006960 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 754252006961 DNA-binding interface [nucleotide binding]; DNA binding site 754252006962 putative transposase OrfB; Reviewed; Region: PHA02517 754252006963 HTH-like domain; Region: HTH_21; pfam13276 754252006964 Integrase core domain; Region: rve; pfam00665 754252006965 Integrase core domain; Region: rve_3; pfam13683 754252006966 fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377 754252006967 catalytic residue [active] 754252006968 Uncharacterized conserved protein [Function unknown]; Region: COG2353 754252006969 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 754252006970 dimer interface [polypeptide binding]; other site 754252006971 Citrate synthase; Region: Citrate_synt; pfam00285 754252006972 active site 754252006973 citrylCoA binding site [chemical binding]; other site 754252006974 NADH binding [chemical binding]; other site 754252006975 cationic pore residues; other site 754252006976 oxalacetate/citrate binding site [chemical binding]; other site 754252006977 coenzyme A binding site [chemical binding]; other site 754252006978 catalytic triad [active] 754252006979 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 754252006980 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 754252006981 active site 754252006982 catalytic tetrad [active] 754252006983 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 754252006984 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 754252006985 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 754252006986 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 754252006987 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 754252006988 NADH(P)-binding; Region: NAD_binding_10; pfam13460 754252006989 NAD(P) binding site [chemical binding]; other site 754252006990 active site 754252006991 Predicted membrane protein [Function unknown]; Region: COG4270 754252006992 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 754252006993 dimer interface [polypeptide binding]; other site 754252006994 [2Fe-2S] cluster binding site [ion binding]; other site 754252006995 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 754252006996 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 754252006997 Walker A/P-loop; other site 754252006998 ATP binding site [chemical binding]; other site 754252006999 Q-loop/lid; other site 754252007000 ABC transporter signature motif; other site 754252007001 Walker B; other site 754252007002 D-loop; other site 754252007003 H-loop/switch region; other site 754252007004 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 754252007005 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 754252007006 ABC-ATPase subunit interface; other site 754252007007 dimer interface [polypeptide binding]; other site 754252007008 putative PBP binding regions; other site 754252007009 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 754252007010 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 754252007011 intersubunit interface [polypeptide binding]; other site 754252007012 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 754252007013 Mechanosensitive ion channel; Region: MS_channel; pfam00924 754252007014 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 754252007015 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 754252007016 active site 754252007017 NTP binding site [chemical binding]; other site 754252007018 metal binding triad [ion binding]; metal-binding site 754252007019 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 754252007020 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 754252007021 Zn2+ binding site [ion binding]; other site 754252007022 Mg2+ binding site [ion binding]; other site 754252007023 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754252007024 putative substrate translocation pore; other site 754252007025 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754252007026 Homeodomain-like domain; Region: HTH_32; pfam13565 754252007027 putative transposase OrfB; Reviewed; Region: PHA02517 754252007028 Integrase core domain; Region: rve; pfam00665 754252007029 Integrase core domain; Region: rve_3; pfam13683 754252007030 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 754252007031 active site 754252007032 ATP binding site [chemical binding]; other site 754252007033 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 754252007034 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 754252007035 catalytic core [active] 754252007036 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 754252007037 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 754252007038 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 754252007039 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 754252007040 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 754252007041 catalytic residues [active] 754252007042 OsmC-like protein; Region: OsmC; pfam02566 754252007043 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 754252007044 ParB-like nuclease domain; Region: ParBc; pfam02195 754252007045 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 754252007046 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 754252007047 P-loop; other site 754252007048 Magnesium ion binding site [ion binding]; other site 754252007049 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 754252007050 Magnesium ion binding site [ion binding]; other site 754252007051 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 754252007052 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 754252007054 putative inner membrane protein translocase component YidC; Provisional; Region: PRK01315 754252007055 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 754252007056 Haemolytic domain; Region: Haemolytic; pfam01809 754252007057 Ribonuclease P; Region: Ribonuclease_P; pfam00825